RU2559581C2 - Иммунологические исследования с использованием недисперсного хемилюминесцентного реактива - Google Patents
Иммунологические исследования с использованием недисперсного хемилюминесцентного реактива Download PDFInfo
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- RU2559581C2 RU2559581C2 RU2011141265/15A RU2011141265A RU2559581C2 RU 2559581 C2 RU2559581 C2 RU 2559581C2 RU 2011141265/15 A RU2011141265/15 A RU 2011141265/15A RU 2011141265 A RU2011141265 A RU 2011141265A RU 2559581 C2 RU2559581 C2 RU 2559581C2
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| JP2016500002A (ja) * | 2012-10-05 | 2016-01-07 | カリフォルニア インスティテュート オブ テクノロジー | マイクロ流体イメージングおよび分析のための方法およびシステム |
| CN107325324B (zh) * | 2016-04-28 | 2019-08-20 | 中国石油化工股份有限公司 | 阻燃剂、阻燃防静电组合物和阻燃防静电聚丙烯发泡珠粒 |
| CN108152505B (zh) * | 2016-11-22 | 2021-06-04 | 博阳生物科技（上海）有限公司 | 免疫测定方法、用于鉴定免疫测定的系统和试剂盒 |
| CN111272997A (zh) * | 2017-11-27 | 2020-06-12 | 科美诊断技术股份有限公司 | 一种均相免疫检测试剂盒、检测方法及其应用 |
| CN117031033A (zh) * | 2018-02-11 | 2023-11-10 | 科美博阳诊断技术(上海)有限公司 | 一种均相快速检测试剂盒在检测人心肌肌钙蛋白i中的应用 |
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| CN108445216B (zh) * | 2018-02-11 | 2021-10-15 | 科美诊断技术股份有限公司 | 一种人抗缪勒氏管激素测定试剂盒及其制备方法与应用 |
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| CN108490194A (zh) * | 2018-02-11 | 2018-09-04 | 北京科美生物技术有限公司 | 检测卵泡刺激素的均相免疫检测试剂套装及其制备方法和应用 |
| CN110161249A (zh) * | 2018-02-11 | 2019-08-23 | 北京科美生物技术有限公司 | 检测抗-Carp抗体的均相免疫检测试剂盒及其应用 |
| CN108445239B (zh) * | 2018-02-11 | 2021-11-02 | 科美诊断技术股份有限公司 | 检测β人绒毛膜促性腺激素的均相免疫检测试剂套装及其制备方法和应用 |
| CN110161230A (zh) * | 2018-02-11 | 2019-08-23 | 博阳生物科技（上海）有限公司 | 快速检测降钙素原的均相免疫试剂盒、制备方法、检测方法和装置 |
| CN108445238A (zh) * | 2018-02-11 | 2018-08-24 | 北京科美生物技术有限公司 | 检测促黄体生成素的均相免疫检测试剂套装及其制备方法和应用 |
| CN108982879A (zh) * | 2018-04-25 | 2018-12-11 | 上海铭源数康生物芯片有限公司 | 抗缪勒氏管激素光激发化学发光检测试剂盒制备方法及其试剂盒和使用方法 |
| CN116559153A (zh) * | 2018-08-13 | 2023-08-08 | 科美博阳诊断技术(上海)有限公司 | 一种均相化学发光检测试剂盒及其应用 |
| ES2942134T3 (es) | 2018-09-25 | 2023-05-30 | Siemens Healthcare Diagnostics Inc | Composiciones, kits y métodos para ensayos multiplex para corregir la interferencia de biotina en mediciones de analitos diana |
| CN111505302A (zh) * | 2019-01-31 | 2020-08-07 | 博阳生物科技（上海）有限公司 | 快速检测n末端b型脑钠肽的均相免疫试剂盒、制备方法、检测方法和装置 |
| CN111665235A (zh) * | 2019-03-08 | 2020-09-15 | 上海索昕生物科技有限公司 | 一种化学发光微阵列芯片及其应用 |
| CN111665236A (zh) * | 2019-03-08 | 2020-09-15 | 上海索昕生物科技有限公司 | 一种发光微阵列芯片的制备方法及其应用 |
| CN118150554A (zh) * | 2019-03-08 | 2024-06-07 | 上海索昕生物科技有限公司 | 一种化学发光微阵列芯片的应用 |
| CN112240930B (zh) * | 2019-07-19 | 2023-07-18 | 科美博阳诊断技术(上海)有限公司 | 一种均相化学发光分析的方法及其应用 |
| EP4408880A4 (en) * | 2021-09-30 | 2025-02-26 | Siemens Healthcare Diagnostics, Inc. | COMPOSITIONS, KITS AND METHODS FOR DUPLEX IMMUNOASSAY FOR ANTI-SARS-COV-2 ANTIBODIES |
| CN115947714B (zh) * | 2022-11-01 | 2024-05-14 | 上海泰辉生物科技有限公司 | 光化学缓存剂的合成方法 |
| CN118858262B (zh) * | 2024-07-03 | 2025-04-22 | 上海碧云天生物技术股份有限公司 | 高灵敏单组分化学发光底物、长效储存容器及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3817837A (en) * | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US6406667B1 (en) * | 1998-02-18 | 2002-06-18 | Dade Behring Marburg Gmbh | Chemiluminescent compositions for use in detection of multiple analytes |
| RU2213974C1 (ru) * | 2002-04-09 | 2003-10-10 | Баженов Алексей Иванович | Способ одновременного определения нескольких аналитов |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4199559A (en) * | 1974-08-12 | 1980-04-22 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US3996345A (en) * | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4261968A (en) * | 1979-05-10 | 1981-04-14 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| AU636110B2 (en) | 1988-06-08 | 1993-04-22 | Nichols Institute Diagnostics | Assays utilizing sensitizer-induced production of detectable signal |
| JPH04134304A (ja) | 1990-09-26 | 1992-05-08 | Furukawa Electric Co Ltd:The | 光ファイバ用被覆除去装置 |
| US5340716A (en) | 1991-06-20 | 1994-08-23 | Snytex (U.S.A.) Inc. | Assay method utilizing photoactivated chemiluminescent label |
| US5578498A (en) * | 1991-05-22 | 1996-11-26 | Behringwerke Ag | Metal chelate containing compositions for use in chemiluminescent assays |
| US6251581B1 (en) * | 1991-05-22 | 2001-06-26 | Dade Behring Marburg Gmbh | Assay method utilizing induced luminescence |
| DE4221880A1 (de) * | 1992-07-03 | 1994-01-05 | Alfatec Pharma Gmbh | Feste und flüssige Lösungen von schwer wasserlöslichen Arzneistoffen |
| CA2140661A1 (en) * | 1992-07-20 | 1994-02-03 | Sharat Singh | Novel chemiluminescent compounds and methods of use |
| ES2113547T3 (es) * | 1992-07-31 | 1998-05-01 | Behringwerke Ag | Matrices quimioluminiscentes fotoactivables. |
| US7569341B2 (en) * | 1994-01-31 | 2009-08-04 | Trustees Of Boston University | Nucleic acid directed immobilization arrays and methods of assembly |
| US6013439A (en) * | 1995-12-22 | 2000-01-11 | Dade Behring Marburg Gmbh | Detection of differences in nucleic acids |
| DE69736382T2 (de) * | 1996-05-01 | 2007-08-09 | Dade Behring Marburg Gmbh | Chemilumineszente zusammensetungen und ihre verwendung zum nachweis von wasserstoffperoxid |
| FR2750893B1 (fr) | 1996-07-12 | 1998-10-30 | Elf Aquitaine | Procede de synthese de zeolithe avec agitation homogene du milieu, dispositif et application |
| US6531278B1 (en) * | 1998-01-14 | 2003-03-11 | Utah State University | Ligand-DNA composition for capture and detection of contaminants on a solid surface |
| US6365346B1 (en) * | 1998-02-18 | 2002-04-02 | Dade Behring Inc. | Quantitative determination of nucleic acid amplification products |
| DE19808226C1 (de) * | 1998-02-27 | 2000-03-02 | Bruker Analytik Gmbh | Anordnung und Verfahren zur Untersuchung von hydrophilen Makromolekülen in wässriger Lösung |
| US6783947B1 (en) * | 1999-09-09 | 2004-08-31 | Dade Behring Marburg Gmbh | Protecting groups for biological labeling |
| JP3586243B2 (ja) * | 1999-09-29 | 2004-11-10 | 独立行政法人 科学技術振興機構 | 高感度イムノアッセイ法 |
| US6703248B1 (en) * | 1999-12-15 | 2004-03-09 | Dade Behring Marburg Gmbh | Particles for diagnostic and therapeutic use |
| JP4134304B2 (ja) | 2000-01-14 | 2008-08-20 | 独立行政法人科学技術振興機構 | ラベル剤およびそれを用いた高感度分析方法 |
| US6346384B1 (en) * | 2000-03-27 | 2002-02-12 | Dade Behring Inc. | Real-time monitoring of PCR using LOCI |
| US6797481B1 (en) * | 2000-10-17 | 2004-09-28 | Dade Behring Marburg Gmbh | Simultaneous screening of multiple analytes |
| US7635571B2 (en) * | 2000-12-07 | 2009-12-22 | Siemens Healthcare Diagnostics Products Gmbh | Amplified signal in binding assays |
| IL164376A0 (en) * | 2002-04-03 | 2005-12-18 | Applied Research Systems | Ox4or binding agents, their preparation and pharmaceutical compositions containing them |
| US6924154B2 (en) * | 2002-08-20 | 2005-08-02 | Quest Diagnostics Investments Incorporated | Hydrophilic chemilumescent acridinium labeling reagents |
| KR20070099519A (ko) * | 2004-09-17 | 2007-10-09 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 3가 금속 매개 균질 발광 근접 분석 |
| US20060166376A1 (en) * | 2005-01-21 | 2006-07-27 | Craig Alan R | Compositions for use as a signal generation component and methods of using same |
| US7723472B2 (en) * | 2005-02-28 | 2010-05-25 | The Regents Of The University Of California | Extracellular matrix binding chimeric proteins and methods of use thereof |
| EP1808493A3 (en) * | 2006-01-13 | 2007-11-21 | Hybrigenics S.A. | Substrates and methods for assaying deubiquitinating enzymes activity |
-
2009
- 2009-03-12 US US12/403,299 patent/US9347947B2/en active Active
-
2010
- 2010-02-25 RU RU2011141265/15A patent/RU2559581C2/ru active
- 2010-02-25 CN CN201080010999.8A patent/CN102348980B/zh active Active
- 2010-02-25 ES ES10751173.5T patent/ES2665953T3/es active Active
- 2010-02-25 WO PCT/US2010/025433 patent/WO2010104683A1/en not_active Ceased
- 2010-02-25 EP EP10751173.5A patent/EP2406630B1/en active Active
- 2010-02-25 JP JP2011554072A patent/JP2012520378A/ja active Pending
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2016
- 2016-04-18 US US15/131,120 patent/US9720004B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3817837A (en) * | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US6406667B1 (en) * | 1998-02-18 | 2002-06-18 | Dade Behring Marburg Gmbh | Chemiluminescent compositions for use in detection of multiple analytes |
| RU2213974C1 (ru) * | 2002-04-09 | 2003-10-10 | Баженов Алексей Иванович | Способ одновременного определения нескольких аналитов |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2406630B1 (en) | 2018-01-17 |
| RU2011141265A (ru) | 2013-04-20 |
| ES2665953T3 (es) | 2018-04-30 |
| JP2012520378A (ja) | 2012-09-06 |
| EP2406630A4 (en) | 2012-09-26 |
| CN102348980B (zh) | 2015-05-27 |
| US9720004B2 (en) | 2017-08-01 |
| CN102348980A (zh) | 2012-02-08 |
| WO2010104683A1 (en) | 2010-09-16 |
| US9347947B2 (en) | 2016-05-24 |
| US20160231336A1 (en) | 2016-08-11 |
| EP2406630A1 (en) | 2012-01-18 |
| US20100233725A1 (en) | 2010-09-16 |
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