RU2520212C2 - 2-арилпропионовые кислоты и производные, и фармацевтические композиции, содержащие указанные соединения - Google Patents
2-арилпропионовые кислоты и производные, и фармацевтические композиции, содержащие указанные соединения Download PDFInfo
- Publication number
- RU2520212C2 RU2520212C2 RU2011114992/04A RU2011114992A RU2520212C2 RU 2520212 C2 RU2520212 C2 RU 2520212C2 RU 2011114992/04 A RU2011114992/04 A RU 2011114992/04A RU 2011114992 A RU2011114992 A RU 2011114992A RU 2520212 C2 RU2520212 C2 RU 2520212C2
- Authority
- RU
- Russia
- Prior art keywords
- amino
- phenyl
- trifluoromethyl
- thiazol
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08164605.1 | 2008-09-18 | ||
EP08164605A EP2166006A1 (en) | 2008-09-18 | 2008-09-18 | 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them |
PCT/EP2009/062109 WO2010031835A2 (en) | 2008-09-18 | 2009-09-18 | 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2011114992A RU2011114992A (ru) | 2012-10-27 |
RU2520212C2 true RU2520212C2 (ru) | 2014-06-20 |
Family
ID=40291117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2011114992/04A RU2520212C2 (ru) | 2008-09-18 | 2009-09-18 | 2-арилпропионовые кислоты и производные, и фармацевтические композиции, содержащие указанные соединения |
Country Status (18)
Country | Link |
---|---|
US (1) | US8624036B2 (pt) |
EP (2) | EP2166006A1 (pt) |
JP (1) | JP5571669B2 (pt) |
CN (1) | CN102159558B (pt) |
AU (1) | AU2009294558B2 (pt) |
BR (1) | BRPI0918759A2 (pt) |
CA (1) | CA2737099C (pt) |
CY (1) | CY1116176T1 (pt) |
DK (1) | DK2346841T3 (pt) |
ES (1) | ES2534634T3 (pt) |
HR (1) | HRP20150395T1 (pt) |
IL (1) | IL211683A (pt) |
PL (1) | PL2346841T3 (pt) |
PT (1) | PT2346841E (pt) |
RU (1) | RU2520212C2 (pt) |
SI (1) | SI2346841T1 (pt) |
SM (1) | SMT201500098B (pt) |
WO (1) | WO2010031835A2 (pt) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2706232C2 (ru) * | 2015-01-15 | 2019-11-15 | Идорсиа Фармасьютиклз Лтд | Производные (r)-2-метил-пиперазина в качестве модуляторов cxcr3 рецептора |
RU2781280C2 (ru) * | 2017-05-30 | 2022-10-11 | Домпе' Фармачеутичи С.П.А. | Ингибиторы il-8 для применения в лечении и/или профилактике вторичных бактериальных инфекций |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2634185B1 (en) | 2012-03-02 | 2016-01-13 | Sareum Limited | TYK2 kinase inhibitors |
US10561676B2 (en) * | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
JP6239118B2 (ja) * | 2013-09-03 | 2017-11-29 | サリウム リミテッド | 医薬化合物 |
EP3117835A1 (en) * | 2015-07-14 | 2017-01-18 | Dompé farmaceutici s.p.a. | Il-8 inhibitors for use in the treatment of certain urological disorders |
EP3192504A1 (en) | 2016-01-15 | 2017-07-19 | Dompé farmaceutici S.p.A. | Il-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy |
ES2893701T3 (es) * | 2016-01-15 | 2022-02-09 | Dompe Farm Spa | Inhibidores de IL-8 para su uso en el tratamiento de neuropatía periférica inducida por quimioterapia |
EP3518898A4 (en) * | 2016-10-03 | 2020-06-17 | The Children's Medical Center Corporation | PREVENTION AND TREATMENT OF DIABETIC NEPHROPATHY |
GB201617871D0 (en) | 2016-10-21 | 2016-12-07 | Sareum Limited | Pharmaceutical compounds |
US10660909B2 (en) | 2016-11-17 | 2020-05-26 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
EP3342407A1 (en) | 2017-01-03 | 2018-07-04 | Dompé farmaceutici S.p.A. | Il-8 inihibitors for use in the treatment of some urological disorders |
EP3409277A1 (en) * | 2017-05-30 | 2018-12-05 | Dompé farmaceutici s.p.a. | Il-8 inhibitors for use in the treatment and/or prevention of bacterial secondary infections |
EP3476390A1 (en) | 2017-10-24 | 2019-05-01 | Dompé farmaceutici S.p.A. | Il-8 inhibitors for use in the treatment of sarcomas |
WO2019165315A1 (en) | 2018-02-23 | 2019-08-29 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists alone or in combination |
EP3868369A1 (en) | 2020-02-21 | 2021-08-25 | Dompe' Farmaceutici S.P.A. | Cxcl8 inhibitor and pharmaceutical composition thereof for use in the treatment of cancer-related fatigue |
EP3868368A1 (en) | 2020-02-21 | 2021-08-25 | Dompe' Farmaceutici S.P.A. | Cxcl8 (interleukin-8) activity inhibitor and corticosteroid combination and pharmaceutical composition and use thereof |
BR112022018294A2 (pt) | 2020-03-26 | 2023-01-10 | Dompe Farm Spa | Inibidores de cxcl8 para uso no tratamento de covid-19 |
EP4008325A1 (en) | 2020-12-02 | 2022-06-08 | Dompe' Farmaceutici S.P.A. | Cxcl8 inhibitors for use in the treatment of covid-19 |
EP3884932A1 (en) | 2020-03-26 | 2021-09-29 | Dompe' Farmaceutici S.P.A. | Cxcl8 inhibitors for use in the treatment of covid-19 |
EP3907214A1 (en) * | 2020-05-04 | 2021-11-10 | Dompe' Farmaceutici S.P.A. | Co-crystal of ketoprofen, lysine and gabapentin, pharmaceutical compositions and their medical use |
IL302553A (en) | 2020-11-05 | 2023-07-01 | Icahn School Med Mount Sinai | CXCR1/CXCR2 inhibitors for use in the treatment of myelofibrosis |
EP4052702A1 (en) | 2021-03-04 | 2022-09-07 | Dompé farmaceutici S.p.a. | Cxcl8 inhibitor and pharmaceutical composition thereof for use in the treatment of seizures |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4025528A (en) * | 1973-10-24 | 1977-05-24 | Shionogi & Co., Ltd. | Thiazole derivatives of benzoic and phenylalkanoic acids |
GB1481465A (en) * | 1973-10-24 | 1977-07-27 | Shionogi & Co | Thiazole derivatives and the production thereof |
SU1554763A3 (ru) * | 1985-10-16 | 1990-03-30 | Мицубиси Касей Корпорейшн (Фирма) | Способ получени производных тиазола или их солей с щелочными металлами |
EP1123276B1 (en) * | 1998-10-23 | 2003-01-08 | Dompe' S.P.A. | N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5537556B2 (pt) * | 1973-12-27 | 1980-09-29 | ||
JPS565747B2 (pt) * | 1973-10-24 | 1981-02-06 | ||
JPS5629871B2 (pt) * | 1974-05-22 | 1981-07-10 | ||
IT1298214B1 (it) | 1998-01-28 | 1999-12-20 | Dompe Spa | Sali dell'acido (r) 2-(3-benzoilfenil) propionico e loro composizioni farmaceutiche. |
IT1317826B1 (it) * | 2000-02-11 | 2003-07-15 | Dompe Spa | Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8. |
ITMI20012434A1 (it) | 2001-11-20 | 2003-05-20 | Dompe Spa | Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono |
CA2474322A1 (en) * | 2002-01-25 | 2003-07-31 | Kylix Pharmaceuticals B.V. | 4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2 |
SI1776336T1 (sl) * | 2004-03-23 | 2010-01-29 | Dompe Spa | Derivati 2-fenilpropionske kisline in farmacevtski sestavki, ki jih vsebujejo |
PT2024329E (pt) * | 2006-05-18 | 2013-11-04 | Dompe Spa | (2r)-2-[(4-sulfonil)aminofenil]propanamidas e composições farmacêuticas que as contenham |
WO2008075184A2 (en) * | 2006-12-19 | 2008-06-26 | Dompe' Pha.R.Ma S.P.A. | 2-aryl-2-fluoropropanoic acids and derivatives and pharmaceutical compositions containing them |
DE602008005488D1 (de) * | 2007-10-18 | 2011-04-21 | Dompe Spa | (r)-4-(heteroaryl)phenylethylderivate und pharmazeutische zusammensetzungen damit |
-
2008
- 2008-09-18 EP EP08164605A patent/EP2166006A1/en not_active Withdrawn
-
2009
- 2009-09-18 EP EP09783167.1A patent/EP2346841B1/en active Active
- 2009-09-18 PL PL09783167T patent/PL2346841T3/pl unknown
- 2009-09-18 ES ES09783167.1T patent/ES2534634T3/es active Active
- 2009-09-18 CA CA2737099A patent/CA2737099C/en active Active
- 2009-09-18 DK DK09783167.1T patent/DK2346841T3/en active
- 2009-09-18 JP JP2011527334A patent/JP5571669B2/ja active Active
- 2009-09-18 SI SI200931170T patent/SI2346841T1/sl unknown
- 2009-09-18 WO PCT/EP2009/062109 patent/WO2010031835A2/en active Application Filing
- 2009-09-18 AU AU2009294558A patent/AU2009294558B2/en active Active
- 2009-09-18 CN CN200980136860.5A patent/CN102159558B/zh active Active
- 2009-09-18 BR BRPI0918759A patent/BRPI0918759A2/pt not_active Application Discontinuation
- 2009-09-18 US US13/063,105 patent/US8624036B2/en active Active
- 2009-09-18 RU RU2011114992/04A patent/RU2520212C2/ru active
- 2009-09-18 PT PT97831671T patent/PT2346841E/pt unknown
-
2011
- 2011-03-10 IL IL211683A patent/IL211683A/en active IP Right Grant
-
2015
- 2015-04-08 CY CY20151100336T patent/CY1116176T1/el unknown
- 2015-04-09 HR HRP20150395TT patent/HRP20150395T1/hr unknown
- 2015-04-22 SM SM201500098T patent/SMT201500098B/xx unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4025528A (en) * | 1973-10-24 | 1977-05-24 | Shionogi & Co., Ltd. | Thiazole derivatives of benzoic and phenylalkanoic acids |
GB1481465A (en) * | 1973-10-24 | 1977-07-27 | Shionogi & Co | Thiazole derivatives and the production thereof |
SU1554763A3 (ru) * | 1985-10-16 | 1990-03-30 | Мицубиси Касей Корпорейшн (Фирма) | Способ получени производных тиазола или их солей с щелочными металлами |
EP1123276B1 (en) * | 1998-10-23 | 2003-01-08 | Dompe' S.P.A. | N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them |
Non-Patent Citations (1)
Title |
---|
PATANI G.A. et al: "BIOISOSTERISM: A RATIONAL APPROACH IN DRUG DESIGN", CHEMICAL REVIEWS, 1996, vol.96, no.8, p.3147-3176. * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2706232C2 (ru) * | 2015-01-15 | 2019-11-15 | Идорсиа Фармасьютиклз Лтд | Производные (r)-2-метил-пиперазина в качестве модуляторов cxcr3 рецептора |
RU2781280C2 (ru) * | 2017-05-30 | 2022-10-11 | Домпе' Фармачеутичи С.П.А. | Ингибиторы il-8 для применения в лечении и/или профилактике вторичных бактериальных инфекций |
Also Published As
Publication number | Publication date |
---|---|
ES2534634T3 (es) | 2015-04-27 |
RU2011114992A (ru) | 2012-10-27 |
CN102159558B (zh) | 2015-01-07 |
PL2346841T3 (pl) | 2015-07-31 |
AU2009294558B2 (en) | 2014-12-18 |
EP2346841A2 (en) | 2011-07-27 |
AU2009294558A1 (en) | 2010-03-25 |
US20110207785A1 (en) | 2011-08-25 |
EP2346841B1 (en) | 2015-01-14 |
SI2346841T1 (sl) | 2015-07-31 |
BRPI0918759A2 (pt) | 2015-12-29 |
SMT201500098B (it) | 2015-07-09 |
IL211683A (en) | 2014-01-30 |
CA2737099C (en) | 2016-07-05 |
EP2166006A1 (en) | 2010-03-24 |
WO2010031835A3 (en) | 2010-06-24 |
DK2346841T3 (en) | 2015-04-20 |
WO2010031835A2 (en) | 2010-03-25 |
CY1116176T1 (el) | 2017-02-08 |
CN102159558A (zh) | 2011-08-17 |
JP5571669B2 (ja) | 2014-08-13 |
JP2012502957A (ja) | 2012-02-02 |
PT2346841E (pt) | 2015-05-07 |
HRP20150395T1 (hr) | 2015-06-19 |
US8624036B2 (en) | 2014-01-07 |
IL211683A0 (en) | 2011-06-30 |
CA2737099A1 (en) | 2010-03-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC43 | Official registration of the transfer of the exclusive right without contract for inventions |
Effective date: 20151027 |