RU2505531C2 - Этинилиндольные соединения - Google Patents

Этинилиндольные соединения Download PDF

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Publication number
RU2505531C2
RU2505531C2 RU2009147506/04A RU2009147506A RU2505531C2 RU 2505531 C2 RU2505531 C2 RU 2505531C2 RU 2009147506/04 A RU2009147506/04 A RU 2009147506/04A RU 2009147506 A RU2009147506 A RU 2009147506A RU 2505531 C2 RU2505531 C2 RU 2505531C2
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RU
Russia
Prior art keywords
methyl
compound
phenyl
ethynyl
butoxy
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RU2009147506/04A
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English (en)
Russian (ru)
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RU2009147506A (ru
Inventor
Казуюки ОХМОТО
Сатоси ИТАДАНИ
Ёсисуке НАКАЯМА
Дзун ТАКЕУТИ
Манабу ФУДЗИТА
Original Assignee
Оно Фармасьютикал Ко., Лтд.
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Publication of RU2009147506A publication Critical patent/RU2009147506A/ru
Application granted granted Critical
Publication of RU2505531C2 publication Critical patent/RU2505531C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
RU2009147506/04A 2008-12-22 2009-12-21 Этинилиндольные соединения RU2505531C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008325815 2008-12-22
JP2008-325815 2008-12-22

Publications (2)

Publication Number Publication Date
RU2009147506A RU2009147506A (ru) 2011-06-27
RU2505531C2 true RU2505531C2 (ru) 2014-01-27

Family

ID=42110130

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2009147506/04A RU2505531C2 (ru) 2008-12-22 2009-12-21 Этинилиндольные соединения

Country Status (18)

Country Link
US (1) US8115014B2 (cg-RX-API-DMAC7.html)
EP (1) EP2206698B1 (cg-RX-API-DMAC7.html)
JP (2) JP5012884B2 (cg-RX-API-DMAC7.html)
KR (1) KR101464778B1 (cg-RX-API-DMAC7.html)
CN (1) CN101759628B (cg-RX-API-DMAC7.html)
AU (1) AU2009250960C1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0905601A2 (cg-RX-API-DMAC7.html)
CA (1) CA2688614C (cg-RX-API-DMAC7.html)
DK (1) DK2206698T3 (cg-RX-API-DMAC7.html)
ES (1) ES2387185T3 (cg-RX-API-DMAC7.html)
IL (1) IL202869A (cg-RX-API-DMAC7.html)
MX (1) MX2009013926A (cg-RX-API-DMAC7.html)
NZ (1) NZ582208A (cg-RX-API-DMAC7.html)
PL (1) PL2206698T3 (cg-RX-API-DMAC7.html)
PT (1) PT2206698E (cg-RX-API-DMAC7.html)
RU (1) RU2505531C2 (cg-RX-API-DMAC7.html)
TW (1) TWI469965B (cg-RX-API-DMAC7.html)
ZA (1) ZA200909096B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2560147C2 (ru) * 2010-06-21 2015-08-20 Оно Фармасьютикал Ко., Лтд. Новые кристаллические формы 4, 4'- [4-фтор-7({4-[4-(3-фтор-2-метилфенил)бутокси]фенил}этинил)-2-метил-1н-индол-1, 3-диил]дибутановой кислоты, 4, 4'-[2-метил-7-({4-[4-(пентафторфенил)бутокси] фенил}этинил)-1н-индол-1, 3-диил]дибутановой кислоты и 4, 4'-[4-фтор-2-метил-7-({4-[4-(2, 3, 4, 6-тетрафторфенил) бутокси]фенил}этинил)-1н-индол-1, 3-диил]дибутановой кислоты

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KR101171790B1 (ko) 2010-07-30 2012-08-13 현대자동차주식회사 인출식 자전거 캐리어
SI2658844T1 (sl) 2010-12-28 2017-02-28 Sanofi Novi derivati pirimidina, njihova priprava in njihova farmacevtska uporaba kot inhibitorje AKT(PKB) fosforilacije
EP2537866A1 (en) * 2011-06-21 2012-12-26 Serumwerk Bernburg AG Hydroxyethyl starch derivatives, method for manufacturing the same and therapeutical uses thereof
CN103893146A (zh) * 2012-12-25 2014-07-02 天津药物研究院 含福多司坦缓释剂型
WO2020079652A1 (en) * 2018-10-17 2020-04-23 Insilico Medicine Hong Kong Limited Kinase inhibitors
EP4162952A4 (en) * 2020-04-30 2024-08-21 Kyoto University PROPHYLACTIC OR THERAPEUTIC AGENT FOR RNA VIRUS-RELATED DISEASES

Citations (3)

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RU2107682C1 (ru) * 1990-12-12 1998-03-27 Зенека Лимитед Кристаллическая форма n-[4-[5-(циклопентилоксикарбонил) амино-1-метил-индол-3-илметил]-3-метоксибензоил]-2-метилбензолсульфонамида, способ ее получения и фармацевтическая композиция, обладающая активностью антагониста лейкотриенов
WO2005021518A1 (ja) * 2003-09-01 2005-03-10 Ono Pharmaceutical Co., Ltd. 縮環化合物およびその用途
WO2006090817A1 (ja) * 2005-02-25 2006-08-31 Ono Pharmaceutical Co., Ltd. インドール化合物およびその用途

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JPH01192476A (ja) 1988-01-25 1989-08-02 Kawasaki Steel Corp 溶接鋼管の製造方法
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PT93943A (pt) 1989-05-05 1991-02-08 Searle & Co Processo para a preparacao de composicoes contendo compostos indole-2-carboxilato para tratamento de perturbacoes do snc
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CA2019335C (en) 1989-06-27 2000-08-01 Mitoshi Konno Phenylalkan (en)oic acids
WO1994022821A1 (en) 1993-04-05 1994-10-13 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives as testosterone 5 alpha-reductase inhibitors
WO1997013751A1 (en) 1995-10-10 1997-04-17 Pfizer Inc. Indole carbamates as leukotriene antagonists
FR2766824B1 (fr) 1997-07-30 1999-09-10 Adir Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9902455D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
WO2002000646A1 (en) 2000-06-27 2002-01-03 Smithkline Beecham Corporation Fatty acid synthase inhibitors
JP2003025362A (ja) 2001-07-18 2003-01-29 Nippon Tokushu Toryo Co Ltd 通気性を有する発泡プラスチック及びその製法
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EP1515716A2 (en) 2002-04-03 2005-03-23 Astrazeneca AB Indole derivatives having anti-angiogenetic activity
CA2483162C (en) 2002-04-23 2011-08-23 Aventis Pharmaceuticals Inc. Use of 3-substituted amino-1h-indole-2-carboxylic acid and 3-substituted amino benzo[b]thiophene-2-carboxylic acid derivatives as il-4 inhibitors
SE0202241D0 (sv) 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
EP1628970A2 (en) 2003-04-30 2006-03-01 The Institutes of Pharmaceutical Discovery, LLC Heterocycle substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2107682C1 (ru) * 1990-12-12 1998-03-27 Зенека Лимитед Кристаллическая форма n-[4-[5-(циклопентилоксикарбонил) амино-1-метил-индол-3-илметил]-3-метоксибензоил]-2-метилбензолсульфонамида, способ ее получения и фармацевтическая композиция, обладающая активностью антагониста лейкотриенов
WO2005021518A1 (ja) * 2003-09-01 2005-03-10 Ono Pharmaceutical Co., Ltd. 縮環化合物およびその用途
EP1661892A1 (en) * 2003-09-01 2006-05-31 Ono Pharmaceutical Co., Ltd. Condensed ring compound and use thereof
WO2006090817A1 (ja) * 2005-02-25 2006-08-31 Ono Pharmaceutical Co., Ltd. インドール化合物およびその用途

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2560147C2 (ru) * 2010-06-21 2015-08-20 Оно Фармасьютикал Ко., Лтд. Новые кристаллические формы 4, 4'- [4-фтор-7({4-[4-(3-фтор-2-метилфенил)бутокси]фенил}этинил)-2-метил-1н-индол-1, 3-диил]дибутановой кислоты, 4, 4'-[2-метил-7-({4-[4-(пентафторфенил)бутокси] фенил}этинил)-1н-индол-1, 3-диил]дибутановой кислоты и 4, 4'-[4-фтор-2-метил-7-({4-[4-(2, 3, 4, 6-тетрафторфенил) бутокси]фенил}этинил)-1н-индол-1, 3-диил]дибутановой кислоты

Also Published As

Publication number Publication date
JP2010168359A (ja) 2010-08-05
EP2206698A1 (en) 2010-07-14
ES2387185T3 (es) 2012-09-17
JP5012884B2 (ja) 2012-08-29
CN101759628A (zh) 2010-06-30
CA2688614C (en) 2015-01-06
TWI469965B (zh) 2015-01-21
AU2009250960A1 (en) 2010-07-08
CN101759628B (zh) 2013-02-27
MX2009013926A (es) 2010-06-22
PL2206698T3 (pl) 2012-12-31
US20100160647A1 (en) 2010-06-24
KR20100074036A (ko) 2010-07-01
TW201026664A (en) 2010-07-16
US8115014B2 (en) 2012-02-14
NZ582208A (en) 2011-05-27
AU2009250960C1 (en) 2014-01-23
RU2009147506A (ru) 2011-06-27
BRPI0905601A2 (pt) 2012-05-02
PT2206698E (pt) 2012-08-03
CA2688614A1 (en) 2010-06-22
ZA200909096B (en) 2010-09-29
JP2012144546A (ja) 2012-08-02
DK2206698T3 (da) 2012-08-27
IL202869A (en) 2015-02-26
KR101464778B1 (ko) 2014-11-24
AU2009250960B2 (en) 2013-09-05
EP2206698B1 (en) 2012-07-18

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Effective date: 20171222