RU2503682C2 - Антитела и содержащие их фармацевтические композиции, подходящие для ингибирования активности металлопротеинов - Google Patents
Антитела и содержащие их фармацевтические композиции, подходящие для ингибирования активности металлопротеинов Download PDFInfo
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- RU2503682C2 RU2503682C2 RU2009132006/04A RU2009132006A RU2503682C2 RU 2503682 C2 RU2503682 C2 RU 2503682C2 RU 2009132006/04 A RU2009132006/04 A RU 2009132006/04A RU 2009132006 A RU2009132006 A RU 2009132006A RU 2503682 C2 RU2503682 C2 RU 2503682C2
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90285407P | 2007-02-23 | 2007-02-23 | |
| US60/902,854 | 2007-02-23 | ||
| PCT/IL2008/000230 WO2008102359A1 (en) | 2007-02-23 | 2008-02-21 | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009132006A RU2009132006A (ru) | 2011-02-27 |
| RU2503682C2 true RU2503682C2 (ru) | 2014-01-10 |
Family
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| RU2009132006/04A RU2503682C2 (ru) | 2007-02-23 | 2008-02-21 | Антитела и содержащие их фармацевтические композиции, подходящие для ингибирования активности металлопротеинов |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US8324355B2 (enExample) |
| EP (1) | EP2155691B1 (enExample) |
| JP (2) | JP5513130B2 (enExample) |
| KR (1) | KR20090113908A (enExample) |
| CN (1) | CN101702906B (enExample) |
| BR (1) | BRPI0807256A2 (enExample) |
| CA (1) | CA2678304A1 (enExample) |
| IL (2) | IL224120A (enExample) |
| MX (1) | MX2009008914A (enExample) |
| RU (1) | RU2503682C2 (enExample) |
| WO (1) | WO2008102359A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2714043C2 (ru) * | 2014-08-13 | 2020-02-11 | Эа Фарма Ко., Лтд. | Антитела, специфичные к ммр9 |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090113908A (ko) | 2007-02-23 | 2009-11-02 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | 금속단백질 활성 억제용 항체 및 이를 함유하는 약학적 조성물 |
| JP2011506614A (ja) | 2007-12-17 | 2011-03-03 | ダイアックス コーポレーション | Ｍｍｐ−１４結合タンパク質を含む、骨溶解性障害を処置するための組成物および方法 |
| JP2011517320A (ja) * | 2008-03-03 | 2011-06-02 | ダイアックス コーポレーション | メタロプロテアーゼ９結合タンパク質およびメタロプロテアーゼ２結合タンパク質 |
| CA2754072C (en) * | 2009-03-02 | 2019-01-15 | Massachusetts Institute Of Technology | Methods and products for in vivo enzyme profiling |
| WO2011092700A1 (en) | 2010-01-27 | 2011-08-04 | Yeda Research And Development Co. Ltd. | Antibodies that inhibit metalloproteins |
| AU2011293125B2 (en) | 2010-08-27 | 2015-02-05 | Gilead Sciences, Inc. | Antibodies to matrix metalloproteinase 9 |
| CN103370337B (zh) * | 2010-10-28 | 2015-12-09 | 耶达研究及发展有限公司 | 用于产生针对金属酶的抗体的方法 |
| US10314909B2 (en) | 2011-10-21 | 2019-06-11 | Dyax Corp. | Combination therapy comprising an MMP-14 binding protein |
| CA2865501A1 (en) | 2012-02-29 | 2013-09-06 | Gilead Biologics, Inc. | Antibodies to matrix metalloproteinase 9 |
| JP6847660B2 (ja) | 2013-06-07 | 2021-03-24 | マサチューセッツ インスティテュート オブ テクノロジー | リガンドをコードする合成バイオマーカーのアフィニティベースの検出 |
| JP7224092B2 (ja) | 2014-04-03 | 2023-02-17 | ツェー・エス・エル・ベーリング・アクチエンゲゼルシャフト | 免疫グロブリンの噴霧化 |
| US10278178B2 (en) | 2014-05-19 | 2019-04-30 | Qualcomm Incorporated | Apparatus and method for inter-band pairing of carriers for time division duplex transmit- and receive-switching |
| US11452121B2 (en) * | 2014-05-19 | 2022-09-20 | Qualcomm Incorporated | Apparatus and method for synchronous multiplexing and multiple access for different latency targets utilizing thin control |
| EP3424168B1 (en) * | 2016-04-04 | 2022-06-01 | Samsung Electronics Co., Ltd. | Method and apparatus for transmitting and receiving feedback in wireless communication system |
| WO2018148595A1 (en) * | 2017-02-10 | 2018-08-16 | Washington University | Antibodies to tip1 and methods of use thereof |
| AU2018248327B2 (en) | 2017-04-07 | 2024-10-10 | Massachusetts Institute Of Technology | Methods to spatially profile protease activity in tissue and sections |
| WO2019017338A1 (ja) | 2017-07-18 | 2019-01-24 | 第一三共株式会社 | 活性型ｍｍｐ－９結合ペプチド |
| WO2020068920A2 (en) | 2018-09-25 | 2020-04-02 | Massachusetts Institute Of Technology | Lung protease nanosensors and uses thereof |
| EP3911753A1 (en) | 2019-01-17 | 2021-11-24 | Massachusetts Institute of Technology | Sensors for detecting and imaging of cancer metastasis |
| IL264768A (en) * | 2019-02-10 | 2020-08-31 | Sagi Irit | ANTI-MATRIX METALLOPROTEINASE 7 (MMP-7) inhibitory antibody and its use |
| US11332546B2 (en) | 2019-05-21 | 2022-05-17 | The Regents Of The University Of California | Protease inhibitory antibodies and methods of use thereof |
| WO2025075789A1 (en) * | 2023-10-03 | 2025-04-10 | Merck Sharp & Dohme Llc | Immunoassay for detecting tau phosphorylated at serine 413 |
| WO2025076280A1 (en) | 2023-10-05 | 2025-04-10 | Ashibio, Inc. | Methods and compositions for treating mmp-9 mediated disorders |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2193038C2 (ru) * | 1995-11-24 | 2002-11-20 | Йеда Рисерч Энд Дивелопмент Ко., Лтд. | Способ получения металлсодержащих производных бактериохлорофилла, новые металлированные производные бактериохлорофилла, фармацевтическая композиция |
| WO2004087042A2 (en) * | 2003-04-04 | 2004-10-14 | Yeda Research And Development Co. Ltd. | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins |
| EA007273B1 (ru) * | 1998-12-24 | 2006-08-25 | Йеда Рисерч Энд Дивелопмент Ко.Лтд. | Выделенный полипептид, связывающийся с каспазой -8, и способы его применения |
Family Cites Families (15)
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| US4595700A (en) | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| JP3348725B2 (ja) | 1992-04-07 | 2002-11-20 | ブリティッシュ バイオテック ファーマシューティカルズ リミテッド | ヒドロキサム酸ベースのコラゲナーゼとサイトカイン阻害剤 |
| GB9320660D0 (en) | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
| WO1995029689A1 (en) | 1994-04-28 | 1995-11-09 | Merck & Co., Inc. | N-carboxyalkyl derivatives as antidegenerative active agents |
| WO1995029892A1 (en) | 1994-04-28 | 1995-11-09 | The Du Pont Merck Pharmaceutical Company | Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents |
| GB9416897D0 (en) | 1994-08-20 | 1994-10-12 | British Biotech Pharm | Metalloproteinase inhibitors |
| DK0757984T3 (da) | 1995-08-08 | 2003-03-03 | Ono Pharmaceutical Co | Hydroxamsyrederivater, der kan anvendes til inhibering af gelatinase |
| EP0780386B1 (en) | 1995-12-20 | 2002-10-02 | F. Hoffmann-La Roche Ag | Matrix metalloprotease inhibitors |
| AU1529897A (en) | 1996-01-02 | 1997-07-28 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds |
| EP0994104A4 (en) | 1996-06-27 | 2001-09-12 | Ono Pharmaceutical Co | ARYL SULFIDE, SULFOXIDE AND SULPHONE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM AS AN ACTIVE INGREDIENT |
| US6174915B1 (en) | 1997-03-25 | 2001-01-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| YU6701A (sh) | 1998-07-30 | 2003-12-31 | Warner-Lambert Company | Triciklični sulfonamidi i njihovi derivati kao inhibitori matričnih metaloproteinaza |
| KR20090113908A (ko) | 2007-02-23 | 2009-11-02 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | 금속단백질 활성 억제용 항체 및 이를 함유하는 약학적 조성물 |
| WO2011092700A1 (en) | 2010-01-27 | 2011-08-04 | Yeda Research And Development Co. Ltd. | Antibodies that inhibit metalloproteins |
-
2008
- 2008-02-21 KR KR1020097019866A patent/KR20090113908A/ko not_active Ceased
- 2008-02-21 CA CA002678304A patent/CA2678304A1/en not_active Abandoned
- 2008-02-21 US US12/449,728 patent/US8324355B2/en active Active
- 2008-02-21 WO PCT/IL2008/000230 patent/WO2008102359A1/en not_active Ceased
- 2008-02-21 EP EP08710230.7A patent/EP2155691B1/en not_active Not-in-force
- 2008-02-21 JP JP2009550773A patent/JP5513130B2/ja not_active Expired - Fee Related
- 2008-02-21 MX MX2009008914A patent/MX2009008914A/es not_active Application Discontinuation
- 2008-02-21 RU RU2009132006/04A patent/RU2503682C2/ru not_active IP Right Cessation
- 2008-02-21 BR BRPI0807256-6A2A patent/BRPI0807256A2/pt not_active IP Right Cessation
- 2008-02-21 CN CN200880012673.1A patent/CN101702906B/zh not_active Expired - Fee Related
-
2012
- 2012-08-28 US US13/596,090 patent/US8486653B2/en active Active
-
2013
- 2013-01-06 IL IL224120A patent/IL224120A/en active IP Right Grant
- 2013-01-06 IL IL224121A patent/IL224121A/en active IP Right Grant
- 2013-04-29 US US13/872,265 patent/US9416195B2/en not_active Expired - Fee Related
- 2013-07-19 JP JP2013150040A patent/JP5792231B2/ja not_active Expired - Fee Related
-
2016
- 2016-05-23 US US15/161,375 patent/US9902783B2/en active Active
-
2018
- 2018-01-09 US US15/865,479 patent/US20180134808A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2193038C2 (ru) * | 1995-11-24 | 2002-11-20 | Йеда Рисерч Энд Дивелопмент Ко., Лтд. | Способ получения металлсодержащих производных бактериохлорофилла, новые металлированные производные бактериохлорофилла, фармацевтическая композиция |
| EA007273B1 (ru) * | 1998-12-24 | 2006-08-25 | Йеда Рисерч Энд Дивелопмент Ко.Лтд. | Выделенный полипептид, связывающийся с каспазой -8, и способы его применения |
| WO2004087042A2 (en) * | 2003-04-04 | 2004-10-14 | Yeda Research And Development Co. Ltd. | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins |
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| Title |
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| MILER G.P. et al, Expanding the 43C9 class of catalytic antibodies using chain-shuffmg approach, Bioorg. Med. Chem., 1997, v.5(3), p.581-590. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2714043C2 (ru) * | 2014-08-13 | 2020-02-11 | Эа Фарма Ко., Лтд. | Антитела, специфичные к ммр9 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101702906B (zh) | 2014-02-12 |
| WO2008102359A9 (en) | 2009-05-22 |
| US8486653B2 (en) | 2013-07-16 |
| KR20090113908A (ko) | 2009-11-02 |
| US20100233188A1 (en) | 2010-09-16 |
| EP2155691B1 (en) | 2016-01-13 |
| IL224121A (en) | 2016-05-31 |
| JP2010519289A (ja) | 2010-06-03 |
| EP2155691A1 (en) | 2010-02-24 |
| WO2008102359A1 (en) | 2008-08-28 |
| US20180134808A1 (en) | 2018-05-17 |
| US20130224225A1 (en) | 2013-08-29 |
| CA2678304A1 (en) | 2008-08-28 |
| US20160257765A1 (en) | 2016-09-08 |
| US20130030158A1 (en) | 2013-01-31 |
| CN101702906A (zh) | 2010-05-05 |
| RU2009132006A (ru) | 2011-02-27 |
| JP5792231B2 (ja) | 2015-10-07 |
| US9902783B2 (en) | 2018-02-27 |
| IL224120A (en) | 2016-05-31 |
| AU2008218525A1 (en) | 2008-08-28 |
| US8324355B2 (en) | 2012-12-04 |
| US9416195B2 (en) | 2016-08-16 |
| MX2009008914A (es) | 2009-08-28 |
| JP2013241435A (ja) | 2013-12-05 |
| BRPI0807256A2 (pt) | 2014-07-22 |
| JP5513130B2 (ja) | 2014-06-04 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20210222 |