RU2491083C2 - Применение фитоэкдизонов и получение композиции для воздействия на метаболический синдром - Google Patents
Применение фитоэкдизонов и получение композиции для воздействия на метаболический синдром Download PDFInfo
- Publication number
- RU2491083C2 RU2491083C2 RU2010126625/15A RU2010126625A RU2491083C2 RU 2491083 C2 RU2491083 C2 RU 2491083C2 RU 2010126625/15 A RU2010126625/15 A RU 2010126625/15A RU 2010126625 A RU2010126625 A RU 2010126625A RU 2491083 C2 RU2491083 C2 RU 2491083C2
- Authority
- RU
- Russia
- Prior art keywords
- phytoecdysones
- extract
- composition
- mice
- hydroxyecdysone
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 208000001145 Metabolic Syndrome Diseases 0.000 title claims description 24
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 title claims description 24
- 239000000284 extract Substances 0.000 claims abstract description 49
- 240000006162 Chenopodium quinoa Species 0.000 claims abstract description 35
- NKDFYOWSKOHCCO-YPVLXUMRSA-N 20-hydroxyecdysone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@](C)(O)[C@H](O)CCC(C)(O)C)CC[C@]33O)C)C3=CC(=O)[C@@H]21 NKDFYOWSKOHCCO-YPVLXUMRSA-N 0.000 claims abstract description 15
- HXWZQRICWSADMH-SEHXZECUSA-N 20-hydroxyecdysone Natural products CC(C)(C)CC[C@@H](O)[C@@](C)(O)[C@H]1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@]4(C)[C@H]3CC[C@]12C HXWZQRICWSADMH-SEHXZECUSA-N 0.000 claims abstract description 15
- 241000124008 Mammalia Species 0.000 claims abstract description 15
- NKDFYOWSKOHCCO-UHFFFAOYSA-N beta-ecdysone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C)(O)C(O)CCC(C)(O)C)CCC33O)C)C3=CC(=O)C21 NKDFYOWSKOHCCO-UHFFFAOYSA-N 0.000 claims abstract description 15
- 210000000579 abdominal fat Anatomy 0.000 claims abstract description 11
- 235000013305 food Nutrition 0.000 claims description 22
- 238000011282 treatment Methods 0.000 claims description 17
- 230000037396 body weight Effects 0.000 claims description 7
- 235000015872 dietary supplement Nutrition 0.000 claims description 5
- 229930182490 saponin Natural products 0.000 claims description 4
- 150000007949 saponins Chemical class 0.000 claims description 4
- 235000017709 saponins Nutrition 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 12
- 239000003814 drug Substances 0.000 abstract description 7
- 239000000126 substance Substances 0.000 abstract description 5
- 241000699670 Mus sp. Species 0.000 description 46
- 235000005911 diet Nutrition 0.000 description 27
- 230000037213 diet Effects 0.000 description 27
- 241000196324 Embryophyta Species 0.000 description 21
- 235000015277 pork Nutrition 0.000 description 17
- 206010033307 Overweight Diseases 0.000 description 12
- 208000008589 Obesity Diseases 0.000 description 11
- 210000001789 adipocyte Anatomy 0.000 description 11
- 235000020824 obesity Nutrition 0.000 description 11
- 235000013339 cereals Nutrition 0.000 description 10
- 238000009825 accumulation Methods 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 7
- 230000007423 decrease Effects 0.000 description 7
- 238000011161 development Methods 0.000 description 7
- 238000009826 distribution Methods 0.000 description 7
- 238000000605 extraction Methods 0.000 description 7
- 239000007903 gelatin capsule Substances 0.000 description 6
- 239000000419 plant extract Substances 0.000 description 6
- 208000024172 Cardiovascular disease Diseases 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 230000003187 abdominal effect Effects 0.000 description 5
- 235000020940 control diet Nutrition 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 235000016709 nutrition Nutrition 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 208000004611 Abdominal Obesity Diseases 0.000 description 4
- 230000037406 food intake Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 206010065941 Central obesity Diseases 0.000 description 3
- 208000032928 Dyslipidaemia Diseases 0.000 description 3
- 208000017170 Lipid metabolism disease Diseases 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 210000000577 adipose tissue Anatomy 0.000 description 3
- 230000000923 atherogenic effect Effects 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 235000013376 functional food Nutrition 0.000 description 3
- 230000002710 gonadal effect Effects 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 235000021590 normal diet Nutrition 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 206010033675 panniculitis Diseases 0.000 description 3
- 230000008092 positive effect Effects 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 244000300264 Spinacia oleracea Species 0.000 description 2
- 235000009337 Spinacia oleracea Nutrition 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 150000002061 ecdysteroids Chemical class 0.000 description 2
- 230000003862 health status Effects 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 201000001421 hyperglycemia Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
- 230000004584 weight gain Effects 0.000 description 2
- 235000019786 weight gain Nutrition 0.000 description 2
- 240000008620 Fagopyrum esculentum Species 0.000 description 1
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 240000003183 Manihot esculenta Species 0.000 description 1
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 229930194930 Triterpen Natural products 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000004251 balanced diet Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- KTUQUZJOVNIKNZ-UHFFFAOYSA-N butan-1-ol;hydrate Chemical compound O.CCCCO KTUQUZJOVNIKNZ-UHFFFAOYSA-N 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000000731 choleretic agent Substances 0.000 description 1
- 230000001989 choleretic effect Effects 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 235000019543 dairy drink Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000021004 dietary regimen Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 239000002031 ethanolic fraction Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000019138 food restriction Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000021233 hypercaloric diet Nutrition 0.000 description 1
- 208000006575 hypertriglyceridemia Diseases 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 210000001596 intra-abdominal fat Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 125000003523 triterpene group Chemical group 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/168—Steroids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/184—Hormones
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0759478 | 2007-11-30 | ||
| FR0759478A FR2924346B1 (fr) | 2007-11-30 | 2007-11-30 | Utilisation de phytoecdysones dans la preparation d'une composition pour agir sur le syndrome metabolique. |
| PCT/FR2008/052088 WO2009071804A2 (fr) | 2007-11-30 | 2008-11-19 | Utilisation de phytoecdysones dans la preparation d'une composition pour agir sur le syndrome metabolique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010126625A RU2010126625A (ru) | 2012-01-10 |
| RU2491083C2 true RU2491083C2 (ru) | 2013-08-27 |
Family
ID=39473912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010126625/15A RU2491083C2 (ru) | 2007-11-30 | 2008-11-19 | Применение фитоэкдизонов и получение композиции для воздействия на метаболический синдром |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8236359B2 (enExample) |
| EP (1) | EP2217255B1 (enExample) |
| JP (1) | JP2011504921A (enExample) |
| CN (1) | CN102231986B (enExample) |
| AU (1) | AU2008332981B2 (enExample) |
| BR (1) | BRPI0820455B8 (enExample) |
| CA (1) | CA2706821A1 (enExample) |
| ES (1) | ES2747932T3 (enExample) |
| FR (1) | FR2924346B1 (enExample) |
| PL (1) | PL2217255T3 (enExample) |
| RU (1) | RU2491083C2 (enExample) |
| WO (1) | WO2009071804A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2982489B1 (fr) * | 2011-11-10 | 2013-12-27 | Inst Biophytis Sas | Phytoecdysones pour leur utilisation dans la stabilisation du poids apres un regime amaigrissant |
| FR2983733B1 (fr) | 2011-12-13 | 2017-12-22 | Inst Biophytis Sas | Phytoecdysones pour leur utilisation dans l'amelioration de la qualite musculaire de mammiferes obeses et/ou sarcopeniques |
| US10441594B2 (en) * | 2013-12-06 | 2019-10-15 | Rutgers, The State University Of New Jersey | Methods of making quinoa leachates and uses thereof |
| CN103837615B (zh) * | 2014-02-15 | 2015-05-20 | 青岛农业大学 | 一种应用高效液相色谱法同时测定植物蜕皮激素类物质的方法 |
| FR3078252B1 (fr) * | 2018-02-28 | 2020-08-14 | Biophytis | Phytoecdysones pour leur utilisation dans la prevention de la perte de force musculaire lors d’une immobilisation |
| RU2764439C1 (ru) * | 2021-04-09 | 2022-01-17 | Федеральное государственное бюджетное учреждение науки "Федеральный исследовательский центр питания, биотехнологии и безопасности пищи" | Способ получения экстракта из зерен киноа, обогащенного фитоэкдистероидами |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557324A (zh) * | 2004-01-13 | 2004-12-29 | 秋 陈 | 蜕皮甾酮在制备治疗胰岛素抵抗药物中的应用 |
| RU2290185C1 (ru) * | 2005-07-26 | 2006-12-27 | Дмитрий Николаевич Мясников | Композиция для нормализации липидного обмена и снижения массы тела и способ её получения |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS632928A (ja) * | 1986-06-20 | 1988-01-07 | Japan Bio Kenkyusho:Kk | 鎮痛剤 |
| JPH04124135A (ja) * | 1990-09-14 | 1992-04-24 | Veritas:Kk | 抗糖尿病薬 |
| JP3862295B2 (ja) * | 1993-09-30 | 2006-12-27 | 独立行政法人理化学研究所 | 抗肥満剤 |
| JP4676040B2 (ja) * | 1997-07-31 | 2011-04-27 | 株式会社林原生物化学研究所 | 組成物 |
| JP3873097B2 (ja) * | 1997-11-06 | 2007-01-24 | 独立行政法人理化学研究所 | 抗肥満剤及び脂質代謝改善剤 |
| JP3858055B2 (ja) * | 2000-02-29 | 2006-12-13 | 独立行政法人理化学研究所 | 抗肥満剤及び脂質代謝改善剤 |
| CN1280010A (zh) * | 2000-06-12 | 2001-01-17 | 昆明制药股份有限公司 | 一种治疗糖尿病的口服药物及其生产方法 |
| EP1534082A4 (en) * | 2002-08-14 | 2006-05-10 | Bionutrigen Co Ltd | POWDER OR EXTRACTS FROM PLANT BLOOMS WITH EFFECTS OF GRAVITY AND COMPREHENSIVE GRAVITY OF ELASTIC FOOD |
| JP4124135B2 (ja) | 2004-02-13 | 2008-07-23 | 株式会社デンソー | ガスセンサ |
| GB2420066A (en) * | 2004-11-23 | 2006-05-17 | Nor Feed As | Feed additive derived from plant material originating from quinoa (Chenopodium quinoa) |
| US8377915B2 (en) * | 2006-05-09 | 2013-02-19 | Rutgers, The State University Of New Jersey | Methods for treating or preventing disorders using ecdysteroid compositions |
| CN101011436A (zh) * | 2007-01-20 | 2007-08-08 | 苏州大学 | 牛膝总甾酮的医药用途 |
-
2007
- 2007-11-30 FR FR0759478A patent/FR2924346B1/fr active Active
-
2008
- 2008-11-19 ES ES08856497T patent/ES2747932T3/es active Active
- 2008-11-19 BR BRPI0820455A patent/BRPI0820455B8/pt active IP Right Grant
- 2008-11-19 JP JP2010535430A patent/JP2011504921A/ja active Pending
- 2008-11-19 PL PL08856497T patent/PL2217255T3/pl unknown
- 2008-11-19 AU AU2008332981A patent/AU2008332981B2/en active Active
- 2008-11-19 CN CN200880118514.XA patent/CN102231986B/zh active Active
- 2008-11-19 WO PCT/FR2008/052088 patent/WO2009071804A2/fr not_active Ceased
- 2008-11-19 RU RU2010126625/15A patent/RU2491083C2/ru active
- 2008-11-19 EP EP08856497.6A patent/EP2217255B1/fr active Active
- 2008-11-19 US US12/745,315 patent/US8236359B2/en active Active
- 2008-11-19 CA CA2706821A patent/CA2706821A1/fr not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557324A (zh) * | 2004-01-13 | 2004-12-29 | 秋 陈 | 蜕皮甾酮在制备治疗胰岛素抵抗药物中的应用 |
| RU2290185C1 (ru) * | 2005-07-26 | 2006-12-27 | Дмитрий Николаевич Мясников | Композиция для нормализации липидного обмена и снижения массы тела и способ её получения |
Non-Patent Citations (2)
| Title |
|---|
| Catalan RE et all. Alterations in rat lipid metabolism following ecdysteron treatment // Comp. Biochem. Physiol., Vol.81B, №3, pp.771-775, 1985. * |
| Nanqun Zhu et all. Ecdysteroids of Quinoa Seeds (Chenopodium quinoa Willd // J. Agric. Food Chem., 2011, 49, 2576-2578. Lafont R., Dian L. Practical uses for ecdysteroids in mammals including humans: an update // J. Insect Sci., 2003, 3:7. * |
Also Published As
| Publication number | Publication date |
|---|---|
| US8236359B2 (en) | 2012-08-07 |
| CN102231986B (zh) | 2014-01-22 |
| WO2009071804A2 (fr) | 2009-06-11 |
| BRPI0820455B8 (pt) | 2021-05-25 |
| PL2217255T3 (pl) | 2020-06-01 |
| WO2009071804A3 (fr) | 2010-04-22 |
| EP2217255A2 (fr) | 2010-08-18 |
| BRPI0820455B1 (pt) | 2020-09-24 |
| AU2008332981B2 (en) | 2014-06-12 |
| RU2010126625A (ru) | 2012-01-10 |
| CA2706821A1 (fr) | 2009-06-11 |
| US20110033561A1 (en) | 2011-02-10 |
| EP2217255B1 (fr) | 2019-07-03 |
| AU2008332981A1 (en) | 2009-06-11 |
| CN102231986A (zh) | 2011-11-02 |
| FR2924346A1 (fr) | 2009-06-05 |
| ES2747932T3 (es) | 2020-03-12 |
| AU2008332981A2 (en) | 2010-07-22 |
| JP2011504921A (ja) | 2011-02-17 |
| BRPI0820455A2 (pt) | 2015-09-29 |
| FR2924346B1 (fr) | 2010-02-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6468962B1 (en) | Nutritional intervention composition for enhancing and extending satiety | |
| CN1901920B (zh) | 含有氨基葡糖的食物组合物 | |
| JP5985138B2 (ja) | エネルギー消費促進剤 | |
| CN117958446B (zh) | 一种减重降体脂的组合物、制备方法及其应用 | |
| RU2491083C2 (ru) | Применение фитоэкдизонов и получение композиции для воздействия на метаболический синдром | |
| KR20120097516A (ko) | 고지혈증 개선제 및 빈혈 개선 조성물, 요산치 저하 조성물 및 음식품 | |
| US8722614B2 (en) | Adiponectin production enhancer | |
| CN103190483A (zh) | 儿童成长奶茶 | |
| JP2017509639A (ja) | 体重管理にシンナムアルデヒド及び亜鉛を用いるための方法及び組成物 | |
| EP3302453B1 (en) | Compositions comprising cinnamaldehyde and zinc and methods of using such compositions | |
| JPH11180869A (ja) | 血中脂質改善剤、サイクリックａｍｐホスホジエステラーゼ阻害剤、飲食品および皮膚外用剤 | |
| JP5706142B2 (ja) | フユボダイジュ花のエタノール抽出物を有効成分とする血中グルコース低下剤、内臓脂肪蓄積抑制剤、ｔｇ低下剤、糞中脂肪排泄促進剤 | |
| CN103108644B (zh) | 脂质燃烧或者能量代谢促进剂 | |
| JP2004000171A (ja) | マカを含有した機能性食品 | |
| JP6629732B2 (ja) | シンナムアルデヒドを使用したエネルギー消費を増大するための方法及び組成物 | |
| ES2815351T3 (es) | Péptidos marinos y nucleótidos de pescado, composiciones y sus usos para reducir la glucosa en sangre | |
| Kumaraswamy et al. | Scientific evaluation of anti-obesity potential of aqueous seed kernel extract of Mangifera indica Linn. in high fat diet induced obese rats | |
| Dubick | Dietary supplements and health aids—A critical evaluation Part 3—Natural and miscellaneous products | |
| US20150366938A1 (en) | Nutritional supplement for patients suffering from rheumatic diseases | |
| WO2015190682A1 (ko) | 쿠마린산을 유효성분으로 포함하는 성장 촉진용 조성물 | |
| JP2002255839A (ja) | 抗肥満剤 | |
| CN119699591A (zh) | 一种用于减脂和增肌的复方营养制剂及其制备方法 | |
| TWI565469B (zh) | 有助於心血管保健之中草藥組合物 | |
| WO2005079824A1 (ja) | 竹エキスを主成分とした飲料及び医薬 | |
| US8613960B2 (en) | Formulations and methods for reducing waist circumference |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD4A | Correction of name of patent owner |