RU2490258C2 - ПРОИЗВОДНЫЕ ГИДРОБЕНЗАМИДА В КАЧЕСТВЕ ИНГИБИТОРОВ Hsp90 - Google Patents
ПРОИЗВОДНЫЕ ГИДРОБЕНЗАМИДА В КАЧЕСТВЕ ИНГИБИТОРОВ Hsp90 Download PDFInfo
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- RU2490258C2 RU2490258C2 RU2009117589/04A RU2009117589A RU2490258C2 RU 2490258 C2 RU2490258 C2 RU 2490258C2 RU 2009117589/04 A RU2009117589/04 A RU 2009117589/04A RU 2009117589 A RU2009117589 A RU 2009117589A RU 2490258 C2 RU2490258 C2 RU 2490258C2
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- formula
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- anticancer drug
- acid addition
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- 239000003481 heat shock protein 90 inhibitor Substances 0.000 title abstract 2
- VUYRFIIFTJICNA-LKNRODPVSA-N (e)-n-[[(e)-benzylideneamino]-phenylmethyl]-1-phenylmethanimine Chemical class C=1C=CC=CC=1/C=N/C(C=1C=CC=CC=1)\N=C\C1=CC=CC=C1 VUYRFIIFTJICNA-LKNRODPVSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 30
- 238000000034 method Methods 0.000 claims abstract 18
- 150000003839 salts Chemical class 0.000 claims abstract 13
- 239000002253 acid Substances 0.000 claims abstract 10
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims abstract 6
- 230000000694 effects Effects 0.000 claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 239000002246 antineoplastic agent Substances 0.000 claims 10
- 229940041181 antineoplastic drug Drugs 0.000 claims 10
- 125000006239 protecting group Chemical group 0.000 claims 7
- 239000012458 free base Substances 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 238000005984 hydrogenation reaction Methods 0.000 claims 5
- 206010059866 Drug resistance Diseases 0.000 claims 4
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 claims 4
- 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 230000003993 interaction Effects 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 238000010640 amide synthesis reaction Methods 0.000 claims 2
- 210000000481 breast Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 210000002249 digestive system Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 210000002615 epidermis Anatomy 0.000 claims 2
- 210000003238 esophagus Anatomy 0.000 claims 2
- 210000000232 gallbladder Anatomy 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 210000003739 neck Anatomy 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 210000002307 prostate Anatomy 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 210000001685 thyroid gland Anatomy 0.000 claims 2
- 229910052723 transition metal Inorganic materials 0.000 claims 2
- 150000003624 transition metals Chemical class 0.000 claims 2
- 208000010570 urinary bladder carcinoma Diseases 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 0 CN(*)c(c(O*)c1)cc(C(C[C@](CC2)Cc3c2ccc(C*2CCC(CC*)CC2)c3)=O)c1O* Chemical compound CN(*)c(c(O*)c1)cc(C(C[C@](CC2)Cc3c2ccc(C*2CCC(CC*)CC2)c3)=O)c1O* 0.000 description 1
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- C07C67/317—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82924306P | 2006-10-12 | 2006-10-12 | |
| US60/829,243 | 2006-10-12 | ||
| GB0620259.2 | 2006-10-12 | ||
| GBGB0620259.2A GB0620259D0 (en) | 2006-10-12 | 2006-10-12 | Pharmaceutical compounds |
| PCT/GB2007/003871 WO2008044034A1 (en) | 2006-10-12 | 2007-10-12 | Hydrobenzamide derivatives as inhibitors of hsp90 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009117589A RU2009117589A (ru) | 2010-11-20 |
| RU2490258C2 true RU2490258C2 (ru) | 2013-08-20 |
Family
ID=37491396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009117589/04A RU2490258C2 (ru) | 2006-10-12 | 2007-10-12 | ПРОИЗВОДНЫЕ ГИДРОБЕНЗАМИДА В КАЧЕСТВЕ ИНГИБИТОРОВ Hsp90 |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US8653084B2 (https=) |
| EP (2) | EP2081895B1 (https=) |
| JP (1) | JP5726416B2 (https=) |
| KR (1) | KR101571568B1 (https=) |
| CN (1) | CN101848892B (https=) |
| AU (1) | AU2007306104B2 (https=) |
| BR (1) | BRPI0719879A8 (https=) |
| CA (1) | CA2665931C (https=) |
| CY (2) | CY1113873T1 (https=) |
| DK (2) | DK2546233T3 (https=) |
| ES (2) | ES2662359T3 (https=) |
| GB (1) | GB0620259D0 (https=) |
| HR (2) | HRP20130255T1 (https=) |
| HU (1) | HUE037268T2 (https=) |
| IL (1) | IL197934A (https=) |
| LT (1) | LT2546233T (https=) |
| ME (1) | ME01874B (https=) |
| MX (1) | MX2009003739A (https=) |
| NO (1) | NO342242B1 (https=) |
| NZ (1) | NZ576110A (https=) |
| PL (2) | PL2081895T3 (https=) |
| PT (2) | PT2081895E (https=) |
| RS (2) | RS52716B (https=) |
| RU (1) | RU2490258C2 (https=) |
| SI (2) | SI2546233T1 (https=) |
| TW (1) | TWI429638B (https=) |
| WO (1) | WO2008044034A1 (https=) |
| ZA (1) | ZA200902270B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101411167B1 (ko) | 2005-04-13 | 2014-06-23 | 아스텍스 테라퓨틱스 리미티드 | 하이드록시벤즈아미드 유도체 및 ｈｓｐ90 억제제로서의이의 용도 |
| US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
| JP5410285B2 (ja) * | 2006-10-12 | 2014-02-05 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| WO2008044041A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| JP5528807B2 (ja) * | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| GB0806527D0 (en) | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| US9096518B2 (en) | 2009-06-22 | 2015-08-04 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| GB201009853D0 (en) | 2010-06-11 | 2010-07-21 | Chroma Therapeutics Ltd | HSP90 inhibitors |
| SMT201900660T1 (it) * | 2012-02-09 | 2020-01-14 | Univ Kansas | Inibitori c-terminali di hsp90 |
| MX2014014188A (es) * | 2012-05-25 | 2015-05-11 | Berg Llc | Metodos para tratar un sindrome metaboilico mediante la modulacion de la proteina de choque termico (hsp) 90-beta. |
| WO2015140624A1 (en) | 2014-03-20 | 2015-09-24 | Otsuka Pharmaceutical Co., Ltd. | Pharmaceutical formulation comprising a substitued phenyl- (1, 3-dihydro-isoindol-2-yl) -methanone |
| US10023864B2 (en) | 2014-06-06 | 2018-07-17 | Berg Llc | Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-beta |
| CN115397811B (zh) * | 2020-01-20 | 2025-05-23 | 奈奥芬莱有限公司 | 与atp结合位点结合的异吲哚啉衍生物 |
| GB202008201D0 (en) | 2020-06-01 | 2020-07-15 | Neophore Ltd | Inhibitor compounds |
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| CN117700350A (zh) * | 2023-03-31 | 2024-03-15 | 福建医科大学 | 一种靶向降解hsp90蛋白的化合物及其制备方法与应用 |
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