RU2489155C2 - Лечение нейродегенеративных заболеваний - Google Patents
Лечение нейродегенеративных заболеваний Download PDFInfo
- Publication number
- RU2489155C2 RU2489155C2 RU2008142514/15A RU2008142514A RU2489155C2 RU 2489155 C2 RU2489155 C2 RU 2489155C2 RU 2008142514/15 A RU2008142514/15 A RU 2008142514/15A RU 2008142514 A RU2008142514 A RU 2008142514A RU 2489155 C2 RU2489155 C2 RU 2489155C2
- Authority
- RU
- Russia
- Prior art keywords
- selenate
- disease
- pharmaceutically acceptable
- acceptable salt
- dementia
- Prior art date
Links
- 230000004770 neurodegeneration Effects 0.000 title claims abstract 9
- 208000015122 neurodegenerative disease Diseases 0.000 title claims abstract 9
- 238000000034 method Methods 0.000 claims abstract 19
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract 11
- 102000013498 tau Proteins Human genes 0.000 claims abstract 11
- 108010026424 tau Proteins Proteins 0.000 claims abstract 11
- 150000003839 salts Chemical class 0.000 claims abstract 9
- 239000003814 drug Substances 0.000 claims abstract 5
- 230000000694 effects Effects 0.000 claims abstract 5
- 230000026731 phosphorylation Effects 0.000 claims abstract 2
- 238000006366 phosphorylation reaction Methods 0.000 claims abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 6
- 210000004498 neuroglial cell Anatomy 0.000 claims 5
- 210000002569 neuron Anatomy 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 3
- 208000018737 Parkinson disease Diseases 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 102000006378 Catechol O-methyltransferase Human genes 0.000 claims 2
- 108020002739 Catechol O-methyltransferase Proteins 0.000 claims 2
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 claims 2
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 claims 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 2
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 2
- 206010036631 Presenile dementia Diseases 0.000 claims 2
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 206010039966 Senile dementia Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 229960004502 levodopa Drugs 0.000 claims 2
- 208000001282 primary progressive aphasia Diseases 0.000 claims 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims 1
- 101150072844 APOM gene Proteins 0.000 claims 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- KORNTPPJEAJQIU-KJXAQDMKSA-N Cabaser Chemical compound C1=CC([C@H]2C[C@H](CN(CC=C)[C@@H]2C2)C(=O)N(CCCN(C)C)C(=O)NCC)=C3C2=CNC3=C1 KORNTPPJEAJQIU-KJXAQDMKSA-N 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 102000010909 Monoamine Oxidase Human genes 0.000 claims 1
- 108010062431 Monoamine oxidase Proteins 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 1
- 206010033799 Paralysis Diseases 0.000 claims 1
- 208000027089 Parkinsonian disease Diseases 0.000 claims 1
- 206010034010 Parkinsonism Diseases 0.000 claims 1
- 102000006478 Protein Phosphatase 2 Human genes 0.000 claims 1
- 108010058956 Protein Phosphatase 2 Proteins 0.000 claims 1
- BKRGVLQUQGGVSM-KBXCAEBGSA-N Revanil Chemical compound C1=CC(C=2[C@H](N(C)C[C@H](C=2)NC(=O)N(CC)CC)C2)=C3C2=CNC3=C1 BKRGVLQUQGGVSM-KBXCAEBGSA-N 0.000 claims 1
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 1
- 229960003805 amantadine Drugs 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 229960002802 bromocriptine Drugs 0.000 claims 1
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 claims 1
- 229960004596 cabergoline Drugs 0.000 claims 1
- 229960004205 carbidopa Drugs 0.000 claims 1
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 229960003530 donepezil Drugs 0.000 claims 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims 1
- JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 claims 1
- 229960003337 entacapone Drugs 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- JKKFKPJIXZFSSB-CBZIJGRNSA-N estrone 3-sulfate Chemical compound OS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 JKKFKPJIXZFSSB-CBZIJGRNSA-N 0.000 claims 1
- 229960003980 galantamine Drugs 0.000 claims 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims 1
- 230000006951 hyperphosphorylation Effects 0.000 claims 1
- 229960001680 ibuprofen Drugs 0.000 claims 1
- 229960003587 lisuride Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims 1
- 229960004640 memantine Drugs 0.000 claims 1
- 210000002682 neurofibrillary tangle Anatomy 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 229960004851 pergolide Drugs 0.000 claims 1
- YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 claims 1
- 229960003089 pramipexole Drugs 0.000 claims 1
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 claims 1
- 229940063238 premarin Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229960004136 rivastigmine Drugs 0.000 claims 1
- 229960001879 ropinirole Drugs 0.000 claims 1
- UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical compound CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 claims 1
- MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical compound C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 claims 1
- 229960003946 selegiline Drugs 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 229960001685 tacrine Drugs 0.000 claims 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical group C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 claims 1
- -1 trihexylphenidyl hydrochloride Chemical compound 0.000 claims 1
- 101000741929 Caenorhabditis elegans Serine/threonine-protein phosphatase 2A catalytic subunit Proteins 0.000 abstract 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 abstract 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78724006P | 2006-03-29 | 2006-03-29 | |
| USUS60/787,240 | 2006-03-29 | ||
| PCT/AU2007/000391 WO2007109851A1 (en) | 2006-03-29 | 2007-03-29 | Treatment of neurodegenerative diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008142514A RU2008142514A (ru) | 2010-05-10 |
| RU2489155C2 true RU2489155C2 (ru) | 2013-08-10 |
Family
ID=38540722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008142514/15A RU2489155C2 (ru) | 2006-03-29 | 2007-03-29 | Лечение нейродегенеративных заболеваний |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8920851B2 (enExample) |
| EP (1) | EP2004204B1 (enExample) |
| JP (1) | JP5542430B2 (enExample) |
| KR (1) | KR101451439B1 (enExample) |
| CN (1) | CN101478977B (enExample) |
| AU (1) | AU2007231547B2 (enExample) |
| BR (1) | BRPI0709033A2 (enExample) |
| CA (1) | CA2644441C (enExample) |
| DK (1) | DK2004204T3 (enExample) |
| ES (1) | ES2394348T3 (enExample) |
| MX (1) | MX2008012479A (enExample) |
| NZ (2) | NZ571835A (enExample) |
| RU (1) | RU2489155C2 (enExample) |
| WO (1) | WO2007109851A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8067008B2 (en) | 2004-08-23 | 2011-11-29 | Yeda Research And Development Co. | Peptide inhibitors for mediating stress responses |
| DK2004204T3 (da) | 2006-03-29 | 2013-01-07 | Velacor Therapeutics Pty Ltd | Behandling af neurodegenerative sygdomme med selenat |
| WO2007127273A2 (en) * | 2006-04-24 | 2007-11-08 | Alltech, Inc. | Methods and compositions for altering cell function |
| US20100247679A1 (en) * | 2006-04-24 | 2010-09-30 | Alltech, Inc. | Methods and compositions for altering cell function |
| WO2008119109A1 (en) * | 2007-03-29 | 2008-10-09 | Velacor Therapeutics Pty Ltd | Treatment of neurological disorders |
| US8580776B2 (en) * | 2007-07-10 | 2013-11-12 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating neurodegenerating diseases |
| WO2009039586A2 (en) * | 2007-09-28 | 2009-04-02 | Powmri Limited | Biomarkers for parkinson's disease |
| WO2009043106A1 (en) * | 2007-10-03 | 2009-04-09 | Velacor Therapeutics Pty Ltd | Inorganic selenium and angiogenesis |
| WO2009043116A1 (en) * | 2007-10-03 | 2009-04-09 | Velacor Therapeutics Pty Ltd | Methods and compositions for the treatment of phosphatase- related disorders |
| JP2011504474A (ja) * | 2007-11-22 | 2011-02-10 | ベーリンガー インゲルハイム インテルナツィオナール ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルツハイマー氏病を治療するためのMnkインヒビターの使用 |
| JP5328244B2 (ja) * | 2008-07-07 | 2013-10-30 | 株式会社ニュージェン・ファーマ | 筋萎縮性側索硬化症治療剤 |
| EP2485722A1 (en) * | 2009-10-09 | 2012-08-15 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline for the treatment of progressive supranuclear palsy |
| WO2012160563A2 (en) | 2011-05-23 | 2012-11-29 | Yeda Research And Development Co. Ltd. | Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same |
| WO2016150403A1 (en) * | 2015-03-26 | 2016-09-29 | Fujian Tiantai Medical Technology Co. Ltd | Method of diagnosis or treatment of neurological disorders with p75ecd and/or p75 |
| WO2019216589A1 (ko) * | 2018-05-09 | 2019-11-14 | 한국과학기술연구원 | 타우 관련 질환의 예방 또는 치료용 조성물 |
| IL309939A (en) * | 2018-06-29 | 2024-03-01 | Rejuvenate Biomed | Pharmaceutical combination for use in age-related and/or degenerative diseases |
| AU2020247907B2 (en) | 2019-03-26 | 2025-12-11 | Seer, Inc. | Compositions, methods and systems for protein corona analysis from biofluids and uses thereof |
| WO2023029210A1 (zh) * | 2021-08-31 | 2023-03-09 | 上海交通大学医学院附属瑞金医院 | Pp2a激动剂、清除和/或溶解衰老细胞和/或抑制细胞衰老的化合物用于治疗精神障碍 |
| WO2023057422A1 (en) * | 2021-10-06 | 2023-04-13 | Bayer Aktiengesellschaft | Universal buffer in methods for safe and rapid detection of pathogen infection |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2005106871A (ru) * | 2002-08-14 | 2005-10-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Ингибиторы протеинкиназ и их применение |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8601915D0 (en) * | 1986-01-27 | 1986-03-05 | Efamol Ltd | Pharmaceutical compositions |
| JPH04247033A (ja) * | 1991-02-04 | 1992-09-03 | Yoshitomi Pharmaceut Ind Ltd | 神経細胞壊死抑制剤 |
| US6746678B1 (en) * | 1991-02-22 | 2004-06-08 | Howard K. Shapiro | Method of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with medicaments |
| US5695752A (en) | 1992-09-11 | 1997-12-09 | The Regents Of The University Of California | Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor |
| WO1995024920A1 (en) | 1994-03-16 | 1995-09-21 | The Regents Of The University Of California | Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor |
| US6524619B2 (en) | 2000-01-27 | 2003-02-25 | Chronorx, Inc. | Dosage forms useful for modifying conditions and functions associated with hearing loss and/or tinnitus |
| DE10059886A1 (de) | 2000-12-01 | 2002-06-20 | Basf Coatings Ag | Verwendung von wässrigen, physikalisch härtbaren Beschichtungsstoffen auf Polyurethanbasis als Haftgrundierung von Lackierungen |
| GB0202900D0 (en) * | 2002-02-07 | 2002-03-27 | Laxdale Ltd | Novel formulations of drugs |
| CA2523714A1 (en) | 2003-04-30 | 2004-11-18 | The Institutes For Pharmaceutical Discovery, Llc | Substituted carboxylic acids |
| AU2003904328A0 (en) | 2003-08-13 | 2003-08-28 | Garvan Institute Of Medical Research | Diagnosis and treatment of neurodegenerative disorders |
| US20070026090A1 (en) * | 2003-09-05 | 2007-02-01 | Oren Tirosh | Treatment and prevention of inflammatory disease and mitochondrial dysfunction with high dose selenium |
| US20050142216A1 (en) | 2003-12-31 | 2005-06-30 | Rindlesbach Keith A. | Method for reversing Alzheimer dementia |
| US20080004255A1 (en) | 2005-10-14 | 2008-01-03 | Alltech, Inc. | Methods and compositions for altering cell function |
| CN101073584B (zh) * | 2005-10-14 | 2012-10-10 | 全面技术公司 | 改变细胞功能的方法和组合物 |
| CA2644445A1 (en) | 2006-03-29 | 2007-10-04 | Velacor Therapeutics Pty Ltd | Inorganic selenium for treatment of benign tumors |
| DK2004204T3 (da) | 2006-03-29 | 2013-01-07 | Velacor Therapeutics Pty Ltd | Behandling af neurodegenerative sygdomme med selenat |
-
2007
- 2007-03-29 DK DK07718638.5T patent/DK2004204T3/da active
- 2007-03-29 CA CA2644441A patent/CA2644441C/en not_active Expired - Fee Related
- 2007-03-29 MX MX2008012479A patent/MX2008012479A/es active IP Right Grant
- 2007-03-29 KR KR1020087026561A patent/KR101451439B1/ko not_active Expired - Fee Related
- 2007-03-29 CN CN2007800122806A patent/CN101478977B/zh not_active Expired - Fee Related
- 2007-03-29 NZ NZ571835A patent/NZ571835A/en not_active IP Right Cessation
- 2007-03-29 EP EP07718638A patent/EP2004204B1/en not_active Not-in-force
- 2007-03-29 JP JP2009501780A patent/JP5542430B2/ja not_active Expired - Fee Related
- 2007-03-29 WO PCT/AU2007/000391 patent/WO2007109851A1/en not_active Ceased
- 2007-03-29 AU AU2007231547A patent/AU2007231547B2/en not_active Ceased
- 2007-03-29 BR BRPI0709033-1A patent/BRPI0709033A2/pt not_active IP Right Cessation
- 2007-03-29 ES ES07718638T patent/ES2394348T3/es active Active
- 2007-03-29 RU RU2008142514/15A patent/RU2489155C2/ru not_active IP Right Cessation
- 2007-03-29 US US12/295,270 patent/US8920851B2/en not_active Expired - Fee Related
- 2007-03-29 NZ NZ596244A patent/NZ596244A/xx not_active IP Right Cessation
-
2013
- 2013-11-14 US US14/079,877 patent/US20140141104A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2005106871A (ru) * | 2002-08-14 | 2005-10-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Ингибиторы протеинкиназ и их применение |
Non-Patent Citations (1)
| Title |
|---|
| ZAFAR KS et al. Dose-dependent protective effect of selenium in rat model of Parkinson's disease: neurobehavioral and neurochemical evidences. J Neurochem. 2003 Feb; 84(3):438-46, он-лайн, [найдено 06.10.2011] найдено из Интернет, http://www.ncbi.nlm.nih.gov/pubmed/12558963. BRENNEISEN H et al. "Selenium, oxidative stress, and health aspects". Mol Aspects Med 2005 Aug-Oct; 26(4-5):256-67, реферат [найдено 19.01.2011], найдено из PubMed PMID: 16105679. * |
Also Published As
| Publication number | Publication date |
|---|---|
| DK2004204T3 (da) | 2013-01-07 |
| EP2004204B1 (en) | 2012-09-12 |
| JP2009532340A (ja) | 2009-09-10 |
| CA2644441C (en) | 2014-09-09 |
| RU2008142514A (ru) | 2010-05-10 |
| KR20090015038A (ko) | 2009-02-11 |
| MX2008012479A (es) | 2009-08-13 |
| CN101478977A (zh) | 2009-07-08 |
| AU2007231547B2 (en) | 2012-07-12 |
| CN101478977B (zh) | 2013-03-27 |
| NZ571835A (en) | 2011-11-25 |
| EP2004204A1 (en) | 2008-12-24 |
| AU2007231547A1 (en) | 2007-10-04 |
| WO2007109851A1 (en) | 2007-10-04 |
| US20090169649A1 (en) | 2009-07-02 |
| NZ596244A (en) | 2013-05-31 |
| US20140141104A1 (en) | 2014-05-22 |
| US8920851B2 (en) | 2014-12-30 |
| KR101451439B1 (ko) | 2014-10-16 |
| BRPI0709033A2 (pt) | 2011-06-21 |
| ES2394348T3 (es) | 2013-01-30 |
| CA2644441A1 (en) | 2007-10-04 |
| EP2004204A4 (en) | 2010-06-02 |
| JP5542430B2 (ja) | 2014-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2489155C2 (ru) | Лечение нейродегенеративных заболеваний | |
| JP2009532340A5 (enExample) | ||
| Dezsi et al. | Monoamine oxidase B inhibitors in Parkinson's disease | |
| JP6766198B2 (ja) | 細胞生存率を向上させるための組成物およびその使用方法 | |
| JP2011522035A5 (enExample) | ||
| CN102065897B (zh) | 基于磺胺异噁唑的组合物用于制备治疗阿茨海默病的药物的应用 | |
| CN102105169B (zh) | 用于治疗帕金森病的药物组合物 | |
| JP2016210798A5 (enExample) | ||
| JP2025521818A (ja) | ブプロピオンとデキストロメトルファンの併用によるデキストロメトルファン低代謝群の治療 | |
| JP2009511618A (ja) | 中度から重度のむずむず脚症候群(rls)を治療するためのプラミペキソールの使用 | |
| JP2020503323A5 (enExample) | ||
| CN101657193A (zh) | 用于治疗纤维肌痛的屈昔多巴及其药物组合物 | |
| MA35513B1 (fr) | Compositions pharmaceutiques comprenant 40 - o - ( 2 - hydroxy) éthyl - rapamycine | |
| HUE034615T2 (en) | New therapeutic approaches for treating parkinson's disease | |
| US20180311236A1 (en) | Use of masitinib and other mast cell inhibitors for treatment of parkinson's disease | |
| TW200738228A (en) | Neramexane modified release matrix tablet | |
| RU2013154699A (ru) | Сцилло-инозитол для применения в лечении поведенческих и психических расстройств | |
| JP2018500300A (ja) | パーキンソン病を遅延させるための医薬 | |
| CN107949379A (zh) | L‑4‑氯代犬尿氨酸的治疗用途 | |
| Lewis et al. | A pharmacokinetic study of an ibuprofen topical patch in healthy male and female adult volunteers | |
| US20170119760A1 (en) | Use of masitinib for the treatment of progressive supranuclear palsy | |
| JP2016505050A5 (enExample) | ||
| Aisen | Anti‐inflammatory therapy for Alzheimer's disease: implications of the prednisone trial | |
| Peskind | Pharmacologic approaches to cognitive deficits in Alzheimer's disease | |
| JP2019504872A5 (enExample) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20160330 |