RU2465890C1 - Composition with colour marker - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to chemical-pharmaceutical industry and represents composition for changing of colour in cleansing composition, which contains at least, one indicator, selected from litmus and carminic acid, light stabiliser, which contains sodium ascorbate, and benzophenone-4-containing antioxidant.

EFFECT: invention ensures effective cleansing and observance of hygienic protocols.

15 cl, 2 ex

Description

BACKGROUND OF THE INVENTION

"Skin hygiene", in particular hands, is the primary mechanism for reducing contact with and transmission of pathogens. According to the Center for Disease Control (CDC), despite public warnings about the need for handwashing, the recommended methods for handwashing are not followed. The population washes their hands either not often enough or not long enough. It should also be noted, however, that washing too long (scrubbing) can damage the skin. The Association of Professionals in Infection Control and Epidemiology (“APIC”) recommends washing your hands by wetting them with running water, applying a handwash, distributing them thoroughly on your hands and rubbing your hands vigorously for 10-15 seconds, while all surfaces of your hands and fingers . APIC recommends washing with antimicrobial soap or detergent, or an alcohol-based detergent for 10-15 seconds, in order to remove or kill transient microorganisms, for example, while feeding or cooking. APIC additionally recommends an antimicrobial soap or detergent with a brush for at least 120 seconds for surgical purposes. It should be noted the difference between the concepts of "destroy" and "delete" microbes. The destruction of microbes can be achieved by using special ingredients that have a lethal effect on the life cycle of microbes. Examples of ingredients that kill germs are triclosan, PCMX (p-chloro-m-xylenol), quaternary salts, surfactants, etc. An example of a formulation designed to kill germs is a disinfectant gel that is applied to hands to kill germs, but which does not remove germs. The use of soap, however, results in disposal combined with a moderate killing effect. In this case, the length of time spent washing your hands can significantly affect the destruction of germs.

Reaching the right time, however, is a question. For children, it is recommended that they sing a song with the alphabet once or “happy birthday” twice in order to wash their hands for 15 seconds. For adults, there is no good indicator of when the time has expired for effective hand washing. Thus, there remains a need for a cleaning composition that will provide the user with an indication of how long he washes his hands to indicate that the cleaning is effective and / or to adhere to hygiene protocols.

SUMMARY OF THE INVENTION

A composition that contains:

a) at least one indicator;

b) at least one light stabilizer; and

c) at least one antioxidant.

The composition can be used in a manner including:

a) applying the composition to a substrate; and

b) leaving the composition on a substrate until a color change is observed.

The present invention relates to a composition that changes color, which remains stable during storage, but changes color when used.

DETAILED DESCRIPTION

As used throughout, ranges are used as a shorthand for describing each value within a range. Any value within the range can be selected as the end point of the range. In addition, all references cited herein are hereby incorporated by reference in their entireties. In the event of a conflict in the definition in the present description and in the cited source, the present description will take precedence.

Unless otherwise indicated, all percentages and amounts expressed herein and elsewhere in the description should be understood as referring to percentages by weight. Amounts are based on the active weight of the substance.

The composition of the present invention is suitable for providing a color change during use in order to show the user that enough time has passed. Time management can have many uses, such as demonstrating that sufficient purification has been performed, that the application time has expired, or that the composition is no longer active.

The composition can be used to calculate the time of application of the composition. For example, a composition in the form of a face mask can be used to deliver the active substance to the skin. The composition can be adjusted to select a color change time to show that a sufficient amount of the active substance has been delivered and the face mask can be removed.

Also, the composition may use a color change in order to show that it is no longer active. This would indicate to the user that the composition can be removed from the substrate on which it was applied.

The timing of color changes can be adjusted so that they can be observed by the user. In certain embodiments, a color change is observed by a user during use previously of approximately 5 minutes, approximately 2 minutes, approximately 30 seconds, approximately 25 seconds, approximately 20 seconds, approximately 15 seconds, approximately 10 seconds, approximately 5 seconds, approximately 5 to approximately 30 seconds or 10 to 30 seconds. The amount of time for a color change can be adjusted by changing the concentration of the indicator and / or changing the initial pH. Time is also proportional to the indicator concentration. The higher the indicator content, the longer the time. Also, the farther the pH is from the pH of the skin (5.5), the longer will be the color change time. For example, the composition can be made more alkaline, then a color change would take longer since the pH in the system changes to become more alkaline.

The indicator is on to provide a color change. The indicator can be turned on in any quantity to ensure a color change, which will indicate that sufficient time has passed for washing. The more indicator is included in the composition, the more the color intensity increases and becomes more clearly visible to the user. In one embodiment, the amount of indicator is from 0.01 to 10% by weight. In one embodiment, the amount of the indicator is from 0.01 to 1% by weight. In one embodiment, the amount of the indicator is about 0.5% by weight.

Examples of indicators that can be used include, but are not limited to, litmus, carmine, carminic acid, curry powder, thymol blue, pentamethoxy red, tropeolin O, tropeolin OO, tropeolin OOO, 2,4-dinitrophenol, methyl yellow, methyl orange, bromphenol blue, tetrabromophenol blue, sodium alizarin sulfonate, alpha-naphthyl red, paraethoxychrysoidin, brocresol green, methyl red, bromocresol purple, chlorophenol red, bromothymol blue, paranitrophenol, azolitmin, fe zero red, neutral red, rosin acid, cresol red, naphtholphthalein, phenolphthalein, naphtholbenzene, thymolphthalein, nile blue, alizarin yellow, salicylic yellow, diazo violet, nitramine, poirrier's blue, trinitrobenzoic acid, and blueberry extracts, beetroot, blueberry , cherries, delphinium petals, geranium petals, grapes, grape seed, horse chestnut leaves, morning glory, pansy petals, petunia petals, primrose, poppy petals, purple peonies, red radish, red cabbage, rhubarb, rose petals, strawberries, tea, turmeric, tulip petals, thyme, violet petals and vanilla. In combination, you can use several indicators. In some embodiments, the indicator is selected from litmus and carminic acid. In one embodiment, the indicator is a litmus. Litmus can be provided using lichen extract. Litmus changes color to blue under alkaline conditions and to red under acidic conditions.

The composition can be developed to change color from an initial pH to a higher pH or from an initial pH to a lower pH. The upper and lower pH limits are any pH that the skin can tolerate. In one embodiment, the pH is from 2 to 12. The pH of the composition can be adjusted to any desired initial pH using any desired acid or alkali. In one embodiment, sodium hydroxide (NaOH) may be selected as alkali and citric acid as acid.

A change in pH is achieved by contact with the skin during washing. The pH of the skin is approximately 5.5. When the composition is alkaline, it becomes more acidic during use. When the composition is acidic, the pH changes to less acidic.

In one embodiment, using a litmus as an indicator, the pH can be adjusted to approximately 9.5 with sodium hydroxide. If the pH is too high, the composition can be adjusted back to about 9.5 using citric acid. When using the composition, the blue litmus changes to red upon contact with the skin.

Indicators can degrade under the influence of light on the solution. As for the commercial product, which will be stored on store shelves and in places of use, this product will be exposed to light sources. A light stabilizer is included to overcome exposure to light to allow the product to remain stable throughout its shelf life. Additionally, indicators in solution may oxidize. For a product with an indicator that contains substances or air that oxidizes the indicator, an antioxidant is included to allow the product to remain stable over its shelf life. Degradation by light and oxidation are especially noticeable in litmus and carmine acid.

A light stabilizer is included in the composition. A light stabilizer is any substance that makes the indicator resistant to degradation under the influence of light. In one embodiment, the light stabilizer is an ascorbic acid salt. In one embodiment, the light stabilizer is sodium ascorbate. In this embodiment, sodium ascorbate is particularly suitable for litmus and / or carminic acid.

The light stabilizer may be present in any amount that stabilizes the composition. In one embodiment, the amount is from 0.01 to 1% by weight. In another embodiment, the amount is from 0.05 to 0.5% by weight. In one embodiment, the amount is about 0.25% by weight.

The composition includes an antioxidant. An antioxidant is any substance that makes an indicator resistant to oxidative degradation. In one embodiment, the light stabilizer is benzophenone-4. In this embodiment, benzophenone-4 is particularly suitable for litmus and / or carminic acid.

The antioxidant may be present in any amount that stabilizes the composition. In one embodiment, the antioxidant is present in an amount of from 0.01 to 0.1% by weight. In one embodiment, the amount is about 0.05% by weight.

Light stabilizer and antioxidant can both be independently selected from CTFA's list of antioxidants (Cosmetic, Toiletries, and Fragrance Association). See the list, which has been available since approximately July 2008 at ctfa-online.org. Non-limiting examples include Acacia Catechu wood extract (Acacia catechu), Acacia Victoriae fruit extract, Acanthopanax Senticosus root water (Eleutherococcus), Acer Palmatum leaf extract (Clenaniformes), acetamidocaprilic acid, acetylbenzyloxyperasterone-2-acetone, acetylbenzyloxyperasterone-2-acetone, acetylbenzyloxyperastinone, flowers of Achillea Millefolium, adamantyl carboxamidohydroxylbenzamide, adamantyl carboxamidomethylhydroxylbenzamide, adamantyl dihydrocaffeamide, adamantyl dihydroxybenzamide, adamantyl hydroxybenzamide, adamantylamine adamantylmethylhydroxylterephthalamide, adamantyltrihydroxybenzamide, Aesculus Hippocastanum extract (horse chestnut), Aframomum angustifolium leaf oil, Agastache Rugosa extract, Agrimonia Eupatoria root extract, Alljum root foliage extract, root extract, leaf extract, leaf extract Onion), Allium Odorum seed extract, Alpinia Uraiensis stem / leaf water, Amaranthus Hypochondriacus seed extract, aminoethanesulfonic acid, aminopropyl ascorbyl phosphate, aminopropyl methylenedioxyphenyl phosphate, aminopropyltocopheryl phosphate, flower / leaf extract s / stalks Angelica Furcijuga, Angelica Keiskei extract, Angoroside C, Anserin, Apigenin, Apium Graveolens seed extract (Celery), Arabidopsis Thaliana extract, Arbutin, Alpha Arbutin, Arbutus Unedo fruit extract, Arctium Maritem Artifact extract, Artifon Lappima fruit extract, , Asarum Heterotropoides extract, Asarum Heterotropoides rhizome extract, ascorbic acid, ascorbic acid polypeptide, ascorbyl dipalmitate, ascorbyl glucoside, ascorbillin oleate, ascorbylmethylsilanol peptiblospate, ascorbyl palmitcalbate, alkaliphosphate, ascorbyl palmital peptolbic acid, ascorbyl palmital phosphate, alkaliphosphate, and tocopheryl maleate, asiaticoside, Avena Sativa (Oats) grain extract, Bacillus / rice bran / soy extract enzyme filtrate, Bambusa Vulgaris shoot extract, benzoguanamine, Beta Vulgaris root powder (Beetroot), Betula Ermanii, BHA stems extract, BHA BHT demethoxycurcumin, bis-hydroxyethyltocopherylsuccinoylamidohydroxypropane, bis- (tetramethylhydroxypiperidinyl) sebacate, Boesenbergia pandurata rhizome extract, Borago Officinalis extract, extracted botrytis-tert-butyldobenylbutyldylbutylbutyldylbutyl axillate extract, butylobenedylbutyldyl axyl leaf extract lbenzamid, tert-butilbenzamidogidroksilfenilatsetamid, tert-butilbenzamidometilgidroksilbenzamid, tert-butilfenilimidazolilfenilsulfonamid, 4-butilrezortsinol, caffeic acid, calcium ascorbate, oil seeds Calophyllum Inophyllum, catechins Camellia Sinensis, leaves of Camellia Sinensis extract, oil leaves Camellia Sinensis, flower extract Campsis Grandiflora, fruit extract Capparis Moonii, Capsella Bursa-Pastoris shoot water, Capsicum Annuum fruit extract, carnosic acid, carotenoids, Carpinus Laxiflora stalk extract, Carpinus Tschonoskii stalk extract, Castanopsis Cuspidata stalk extract, root extract Cayaponia Tayuya, Celosia Cristata extract, Cercis Chinensis flower / leaf / stalk extract, Cereus Grandiflorus extract (Cactus), Chaenomeles Sinensis fruit extract, chitosan ascorbate, chitosan glycolate, chitosan salicylate, Chlorogenic acidum, Chumantantum chytumumum flowerflow, Indic Chrysanthemum Indicum flower / leaf / stalk extract, Cimicifuga Dahurica root extract, Cimicifuga Racemosa root extract, Cinnamomum Zeylanicum bark extract, Citrus Junos seed extract, Citrus Medica Vulgaris fruit extract, Citrus Unshiu fruit extract, DNA complex with DNA complex, DNA complex with DNA complex, DNA complex Coffea Arabica fruits, call offensive platinum, flower / leaf / stalk extract Commelina Communis, Cu-adenosine triphosphate, Cu-pyridoxal-5-phosphate, root extract of Coptis Chinensis, extract of Cordyceps Sinensis, leaf extract of Cornus Controversa, crotonic aldehyde extract, Cucumaria fronica extract Tetragonoloba (Guar), Cyclopia Genistoides flower / leaf / stalk extract, Cyclopia Genistoides leaf extract, Cyclopia Subternata flower / leaf / stalk extract, Cycnoches Cooperi extract (Orchid), Cymbidium Goeringii extract, Cynara Cardunculus seed oil, cysteine extract, cystein extract fruits Davidsonia Pruriens, decapeptide-6, decapeptide-7, decursino l detsilmerkaptometilimidazol, demetoksikurkumin, diatsetilkurkumin, diamilgidrohinon, di-tert-butylhydroquinone, ditsetiltiodipropionat, Dictyophora Indusiata extract (Mushroom), Dictyopteris Membranacea extract, dicyclopentadiene copolymer / t-butyl cresol, digalloiltrioleat, dihydroquercetin, digidroksimetilhromon, diizooktilsebakat, dilauryl thiodipropionate, dimetoksibenzamidofenilgidroksilatsetamid, dimetoksidi- p-cresol, dimethylmethoxychromanol, dimyristylthiodipropionate, dioleyltocopherylmethylsilanol, Dioscorea Batatas extract, diosmin, flower calyx extract Diospyros Kaki, ester diretinila, disodium askorbilsulfat, disodium izostearilaskorbilfosfat, disodium rutinildisulfat, disodium salitsilfosfat, disodium ubiquinone, distearyl thiodipropionate, ditridetsiltiodipropionat, dodecyl, powder Dunaliella Bardawil, seed oil Echinops Sphaerocephalus, ellagic acid, flower extract / fruits / leaves Empetrum Nigrum, epigallocatechin gallate , Epimedium Sagittatum leaf / stalk extract, Ergotionin, Erigeron Canadensis flower extract, Eriobotrya Japonica leaf protoplasts, Eriocaulon Buergarianum flower / stalk extract, erythroma ki lot, ethyl bis-iminomethylguaiacol manganese chloride, ethyl ferulate, ethyl hexyl ferulate, ethyl hexyl gallate, Eucommia Ulmoides bark extract, Euphorbia jolkini extract, Euphorbia Supina stem extract, Excoecaria bicolor leaf extract, ferulic acid feruli feruli feruli feruli feruli feruli feruli feruli feruli feruli feruli feruli feruli feruli feruella Forsythia Suspensa fruit, Fragaria Ananassa seed oil (Strawberry), Fragaria Vesca flower extract (Strawberry), Fragilaria Pinnata extract, furfuryl palmitate, Galla Rhois nut extract, extracted Ganoderma Japonicum micellar enzyme filtrate, genistenic leaves ngo, glucosylrutin, glycerylchromonyl ether, glyceryl diferulate, Glycine Max symbiosome extract (Soybeans), Glycine Soja oil (Soybeans), Glycyrrhiza Glabra root extract (Licorice), Glycyrrhiza foliar extract, Glycyrrhiza foliar extract, Grifola Frondosa enzymes (Maitake), Gynostemma Pentaphyllum extract, Gynostemma Pentaphyllum leaf extract, Gynostemma Pentaphyllum leaf / stalk extract, Haematococcus pluvialis oil, Haematococcus geroplexpercus pluvialis powder, Haematococcus pluvialis powder, Pluvialis powder, Pluvialis powder, Pluvialis powder, Pluvialis powder, Pluvialis powder, Pluvialis powder, Pluvialis powder, Pluvialis powder, Plume powder rimethylphenol, honokiol, human oligopeptide-9 hexapeptide-25, hydrolyzed extract of Anona Cherimolia fruits, hydrolyzed extract of Aspergillus / Ginseng enzymes, hydrolyzed extract of Gardenia Florida, hydrolyzed grape skin, hydrolyzed fruit extract, hydrolyzed olive fruit, hydrolyzed barum olives, hydrolyzed barum proanthocyanidin, hydrolyzed rice leaf extract, hydrolyzed enzyme extract Saccharomyces / sodium selenate, hydrolyzed fruit extract Sophora Japonica, hydrolyzed soybean extract, g hydrolyzed wheat pollen / root extract Typha Angustifolia, hydrolyzed wheat bran, hydroquinone, p-hydroxyanisole, hydroxydecylubiquinone, hydroxylamine HCl, hydroxylamine sulfate, hydroxyphenyl dihydroxybenzamide, isocitroate isocitolate , isocvercitrin, Juglans Regia seed coat extract (Chestnut), Juniperus Communis shoot extract, kempferol, kojic acid, koya glycoside, koya methylenedioxycinnamate, Kou-Cha Ekisu, extract f Lactobacillus / Portulaca Oleracea enzyme extract, Lactobacillus enzyme extract / rice bran / Saccharomyces / Camellia sinensis leaves, Lactobacillus enzyme filtrate / Saccharomyces / Pichia Anomala / Camellia sinensis leaf extract / Lactobacillus extract extract / Saccharomycema pomacea leaf extract, Artemaciachomcecomceceps Camellia Sinensis leaf / honey enzyme, Lactobacillus / Saccharomyces / Pichia Anomala filtrate / Camellia Sinensis leaf extract / honey enzyme, Lactobacillus / Wasabia root root extract Wasabia Japonica, Larix Sibirica wood extract, Lawsonia Inermis extract (Simon Charice), Charice Charice) , Lespedeza Cuneata extract, Ligusticum striatum root extract, color extract Lilium Candidum, Lindera Strychnifolia leaf extract, linoleyl gallate, flaxseed oil ascorbic acid esters, Liriodendron Tulipifera leaf water, Lotus Japonicus symbiosome extract, Lupinus subcarnosus symbiosome extract, Lycium Chinense arabic extract, mébecidea mackebiurecope, lycophecus mébécissé, mébécissa mébécideum, méciebécissa mébécieure, mébécieure mébécieure, mébéciebie mucoburis, mébécébémy , Magnesium ascorbate / PCA, Magnesium ascorbyl borate, Magnesium ascorbyl phosphate, Magnolia Grandiflora bark extract, Magnolol, Malachite extract, Mallotus Japonicus leaf extract, Malpighia Punicifolia fruit extract (Acerola), Malus Domestica fruit extract, adenosine dihydrogen phosphate Manganese, Mn-fructose-diphosphate, Mn-pyridoxal-5-phosphate, matrine, Matteuccia Struthiopteris extract, Medicago Sativa symbiosome extract (Lucerne), Melaleuca Alternifolia leaf oil (Tea tree), melatonin, conditioned medium / culture Melia Azadirachta, Metia -7 ascorbic acid, methoxy-PEG-7 rutinyl succinate, methoxytrimethylphenyl dihydroxyphenylpropanol, methyl di-tert-butylhydroxyhydrocinnamate, methylene di-tert-butylcresol, 3,4-methylenedioxybenzylmethylsulfonate, methyl methacrylacrylate / trimethyl acrylate nolascorbate, Mirabilis Jalapa flower extract, Momordica Grosvenori fruit extract, Monascus / Rice enzyme, Morus Alba fruit extract, Morus Alba leaf extract, Morus Alba root extract, Morus Bombycis extract, Morus Bombycis stem extract, Morus bombycis wood extract, Morus bomby leaves of Murraya Exotica extract, Musa Balbisiana fruit extract, an extract of bulbs of Narcissus Tazetta, Nelumbo Nucifera seed extract, niacinamide hydroxybenzoate, niktoflorin, nordigidroguayaretovuyu acid, octadecyl di-tert-butyl-4-hydroxyhydrocinnamate, oktanikotinoil epigallocatechin gallate, 4-octapeptide, kidney extract Olea Europaea (Oliva), flower water Olea Europaea (Oliva), unsaponifiable fruits Olea Europaea (Oliva), oligopeptide-28, oligopeptide-29, oligopeptide-30, oligopeptide-31, Orostachys Japonica extract, Oryza Sativa seed water (Rice), oil Oxycoccus Palustris seed, Paecilomyces Japonica enzyme filtrate / grape / cucumber juice extract, peonol, palmatine, Camellia sinensis palmitoyl extract, coffee bean palmitoyl grape seed palmitoyl, grape seed palmitoyl extract, palmitoyl grape shoot extract, palmitoyl PE extract, pearl olive leaf extract -2/5 tocopheryl ether, PEG / PPG-5/10 tocopheryl ether, PEG / PPG-5/20 tocopheryl ether, PEG / PPG-5/30 tocopheryl ether, PEG / PPG-30/10 tocopheryl ether, PEG / PPG-50/20 tocopheryl ether, PEG / PPG-70/30 tocopheryl ether, PEG / PPG-100 / 70 tocopheryl ether, Pelvetia Siliquosa extract, pentaerythritol tetra-di-tert-butylhydroxyhydrocinnamate, Perilla Ocymoides seed extract, perilla alcohol, Peucedanum Japonicum branch extract, Phaseolus angularis shoot extract, Phaeolus phenolus phaeolus ethereum phleolus phenolethella phleolus phleolus phleolus phleolus phleolus phleolus phleolus phleolus phleolus phleolus phleolus phleolus phleolus phleolus phleolus phleolus phlusethella resorcinol, phenylthioglycolic acid, phloretin, phloroglucinol, Physocarpus Amurensis stem extract, phytosteryl linoleate, phytosteryl linoleate / linolenate, p zeatannol, Pikea Robusta extract, Pimpinella Brachycarpa extract, Pinus Densiflora extract, Pinus Densiflora leaf extract, Pinus Nigra kidney / needle extract, Pinus Pinaster kidney / bark extract, Pinus Radiata bark extract, Pinus Sylvestris kidney extract, Pipermentaline ), Piper Umbellatum root extract, Pisum Sativum symbiosome extract, Platycarya Strobilacea branch extract, Platycodon Grandiflorum root extract, Pogostemon Cablin leaf / stem extract, Polygonum Cuspidatum / 82 flower hydromaxidum polysperchidum polysulfrid Stem Portulaca Oleracea, Asko potassium biltocopheryl phosphate, potassium sulfite, leaf extract Pothomorphe Umbellata, PPG-2 tocophere-5, PPG-5 tocoperet-2, PPG-IO tocoperet-30, PPG-20 tocopheret-50, PPG-30 tocoperet-70, PPG-70 tocophere -100, PPG-5 tocopheryl ether, propyl gallate, protocatechaldehyde, Prunella Vulgaris extract, Prunus Cerasus extract (Bird cherry), Prunus Cerasus fruit extract (Bird cherry), Prunus Cerasus leaf extract (Bird cherry), Prunus Prunus mume flowers, Mume flower extract of Prunus Mume flowers, Prunus Salicina fruit extract, Prunus Spinosa wood extract, Prunus Tomentosa fruit extract, Pueraria Lobata symbiosome extract, puerarin, bark / fruit extract s Punica Granatum, pyridoxine hydroxybenzoate, pyridoxine hydroxycitrate, pyridoxine salicylate, pyridoxine serinate, piridiloksid tert-butyl nitrone, skin extract Pyrus Malus (Apple), Quercetin, Quercetin Caprylate, Quercus Infectoria Fruit Extract, Quercus Salicina stems extract rezatsetofenon, resorcinol, resveratrol, retinyl formyl aspartate, Rhodochrosite extract, Rhododendron Mucronulatum flower extract, Rhodymenia Palmata extract, Rhus Javanica extract, Rhus Semialata leaf extract, Rosa Davurica flower extract, Rosa Indica flower extract, Rosa Wichuraiana stem extract, rosmarinic acid flower extract of Rosmarinus Officinalis (Rosemary), leaf extract of Rosmarinus Officinalis (Rosemary), fruit extract of Rubus Arcticus, fruit extract of Rubus Chamaemorus, rutin, rutinil succinate, Ryoku-Cha Ekisu, Saccharomyces enzyme extract / Sarcocomycetes, Sarcocomycera sarcomycecauda, Sarcocomyceae, Sarcocomyceae Pueraria Lobata, Saccharomyces / Rhodobacter / Lactobacillus / Leuconostoc / Streptomyces Griseus / Aspergillus / Bacillus Enzyme Filtrate, Salted Syedin, Sambucus Nigra Kidney Extract, Sanguisorba Minor Fruit Extract, Sangisorbumidum fruit extract, Suminisumumacumatum fruit extract, Sangisarum citrus extractum, Gum extractum, Ecumarum fruit extract Sasa Senanensis, Saururu Flower Extract s Chinensis, Saururus Chinensis leaf / root extract, Schinopsis Quebracho-Colorado wood extract, Schizandra Sphenanthera fruit extract, Sedum Rosea root extract, selenium / shoot extract Glycine Soja (Soybeans), Sideritis Syriaca extract, Smilax China extract , Smilax China root extract, zinc spar extract, sodium ascorbate, sodium ascorbyl / cholesteryl phosphate, sodium ascorbyl phosphate, sodium bisulfite, sodium erythorbate, grape seed sodium phosphate extract, sodium metabisulfite, sodium phosphonopyridoxylidenehodanine, sodium sulfite, thioglycolate Sodium ilphosphate, sodium zinc hydidindithioioctanamide, Solanum Lycopersicum fruit extract (Tomato), Sophora Flavescens root extract, sorbityl furfural, Spirulina Maxima powder, sponge extract, stearyl gallate, Stephanandra Incisa starch extract / Lactobacillus lactobacillus enzyme 6, Syzygium Leuhmanii fruit extract, tangeritin, TBHQ, Terminalia Ferdinandiana fruit extract, tetrabutylethylidine bisphenol, tetrahexyl decyl ascorbate, tetrahydrobis demethoxy diferuloylmethane, tetrahydrocurcumin diacetate, tetrahydrodemethoxydifer uloilmetan, tetragidrodiferuloilmetan, tetrametilbutildigidroksibenzamid, tetrametilhromanolglyukozid, teupoliozid, shell Theobroma Cacao extract (Cocoa) estrakt seed Theobroma Cacao (Cocoa), lipoic acid, thiodiglycol, tiodiglikolamid, thiodiglycolic acid, thioglycolic acid, thiolactic acid, thiosalicylic acid, tiotaurin extract Thuja Orientalis , Thuja Orientalis leaf extract, thymoltrimethoxycinnamate, tococysteamide, tocoferet-5, tocopheret-10, tocopheret-12, tocopheret-18, tocopheret-50, tocopherol, tocopherosolan, tocopheryl acetate, tocopheryl dimethyl glycinate, tocopheryl dimethyl glycinate HCl, tocopheryl linoleate, tocopheryl linoleate / oleate, tocopheryl nicotinate, tocopheryl retinoate, tocopheryl succinate, tocoquinone, toluene, o-tolylbiguanide, Torilis folicariforum extract, Tricolichloriforum folicum nut, Tricoricobacteriforum fruit nut, Tricoricola tomicorum nutformum, Tricoricola tomicoriforum, nut fruit , Trifolium Pratense seed extract (Clover), Trifolium Pratense symbiosome extract (Clover), Trigonella Foenum symbiosome extract, tripropylene glycol, Tris-BHT mesitylene, Tris (nonylphenyl) phosphite, trisodium phosphate ascorbisyl palmitate, trisodium ascorbyl phosphate, tris palmitate, fructose trisodium diphosphate, resveratrol trisodium triphosphate, leaf extract of Triticum aestivum (Wheat), tyrosyl histidine HCl, ubiquinol, ubiquinone, Ulva Lactuca powder, Uuron-Cha Ekisu, fruit powder Vaccinium ecinumium Macrocus, Vaccinium citrusum, Macrocus vaccinium extract Myrtillus, Vaccinium Vitis-Idaea fruit extract, Vaccinium Vitis-Idaea leaf protoplasts, Vaccinium Vitis-Idaea seed oil, Vanda Coerulea extract, Viburnum Awabuki leaf extract, Vicia Sativa symbiosome extract, Viola Mandshurica fruit extract, Vina Vandsrafura fruit extract Vitis Vinifera juice (Grapes), Vitis Vinifera juice extract (Wine hail), Vitis Vinifera seed extract (Grapes), Vitis Vinifera peel extract (Grapes), Vitis Vinifera peel powder (Grapes), volcanic stone, wine extract, xylyldibutylbenzofuranone, zinc adenosine triphosphate, zinc ascorbate, zinc dibutyl dithiocarbisulfonate dicarboxyphosphamide 5 -phosphate zinc. In one embodiment, the light stabilizer and antioxidant are different substances.

In one embodiment, the combination of sodium ascorbate and benzophenone-4 is selected as a light stabilizer and antioxidant, respectively. This combination provides light stability and oxidation resistance. In one embodiment, the amount of sodium ascorbate is about 0.25% by weight, and the amount of benzophenone-4 is about 0.05% by weight.

Stability is measured within 13 weeks for compositions placed in sunlight, for light stability and for oxidation at 25 ° C and 49 ° C. Light stability is measured by reducing color using spectroscopy in the UV and visible regions of the spectrum. Oxidation is measured by color reduction using spectroscopy in the UV and visible regions of the spectrum and using pH measurements. This test can be carried out with 1 g of a sample, which is diluted with 9 g of water to obtain a diluted solution. The diluted solution is placed in a spectrometer in the UV and visible spectral regions. The spectrometer settings in the UV and visible spectral regions are as follows: the wavelength is set for scanning from 400 nm to 800 nm, the scanning speed is set to fast, the cycle time is 60 seconds and the results are recorded as absorption units with a lower limit of 0 and an upper limit equal to 2.

In one embodiment, the composition has a second light absorption value after 13 weeks at 49 ° C., which differs by no more than 20% from the first light absorption value measured initially in a test with a UV and visible spectrometer. The wavelength selected for measurement is based on the absorption peak for the indicator used. For litmus, absorption is measured at approximately 590 nm. When more than one indicator is used, absorption measurements are taken at each absorption peak for each substance. In other embodiments, the implementation of the value differs by no more than 15%, 10% or 5%. In one embodiment, the wavelength used for measurement is 590 nm. In one embodiment, the pH does not change by more than +/- 0.5 units.

When the composition is a detergent, the composition contains at least one surfactant. A surfactant may be one or more anionic surfactants, amphoteric surfactants, nonionic surfactants, cationic surfactants, and a combination thereof. Those skilled in the art will know about suitable surfactants and other additives that are easy to install from the International Cosmetic Ingredient Dictionary and Handbook, 10 ^th ed., (2004). Surfactants may be included in any desired amount. In one embodiment, surfactants are present in the composition in an amount of 0 to 40% by weight. In one embodiment, the surfactants are present in an amount of from 1 to 40% by weight. In one embodiment, surfactants are present in the composition in an amount of 5 to 40% by weight. In one embodiment, surfactants are present in an amount of from 1 to 10% by weight.

Various anionic surfactants can be used in a body wash moisturizing composition, including, for example, long chain alkyl substances (C ₆ -C ₂₂ ), such as long chain alkyl sulfates, long chain alkyl sulfonates, long chain alkyl phosphates, long chain alkyl sulfates, long chain alkyl sulfates alpha-olefin sulfonates, long chain alkyl taurates, long chain alkyl isotionates (SCI), long chain alkyl glyceryl ether sulfonates (AGES), sulfosuccinates and the like. These anionic surfactants can be alkoxylated, for example ethoxylated, although alkoxylation is not required. These surfactants are usually highly soluble in water due to sodium, potassium, alkyl and ammonium or alkanolammonium containing salt forms and can provide high foaming purification. Other equivalent anionic surfactants may be used. In one embodiment, the anionic surfactant comprises sodium laureth sulfate, sodium pareth sulfate, and combinations thereof. Anionic surfactants can be included in any desired amount. In one embodiment, anionic surfactants are present in the composition in an amount of from 0 to 15% by weight. In one embodiment, anionic surfactants are present in an amount of 4 to 12% by weight.

The composition may also include amphoteric surfactants. These surfactants are usually characterized by a combination of high surfactant activity, foaming and softness. Amphoteric surfactants include, but are not limited to, derivatives of aliphatic secondary or tertiary amines in which the aliphatic radical is linear or branched and where one of the aliphatic substituents contains from 8 to 18 carbon atoms and one contains an anionic water-soluble group, for example, carboxy, sulfonate, sulfate, phosphate or phosphonate. Examples of such substances include sodium 3-dodecylaminopropionate, sodium 3-dodecylaminopropane sulfonate, N-alkyl taurines and N-higher aspartic acid alkyls. Other equivalent amphoteric surfactants may be used. Examples of amphoteric surfactants include, but are not limited to, a number of betaines, including, for example, higher alkyl betaines such as cocodimethyl carboxymethyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl alpha carboxyethyl betaine, cetyl dimethyl carboxymethyl bis (b) hydroxymethyl (b) , stearyl bis- (2-hydroxypropyl) carboxymethyl betaine, oleyl dimethyl-gamma-carboxypropyl betaine and lauryl bis (2-hydroxypropyl) alpha-carboxyethyl betaine, sulfobetaines such as cocodi etilsulfopropilbetain, stearyl amido, amidosulfobetaines etc. Long chain alkyl group betaines, in particular coconut ones, can be especially useful, as well as those containing amido groups such as cocamidopropyl and cocoamidoethyl betaines. Amphoteric surfactants may be included in any desired amount. In one embodiment, amphoteric surfactants are present in the composition in an amount of 0 to 15% by weight. In one embodiment, amphoteric surfactants are present in the composition in an amount of from 1 to 6% by weight.

Examples of non-ionic surfactants include, but are not limited to, polysorbate 20, long chain alkyl glucosides with C ₈ -C ₂₂ alkyl groups; coconut fatty acid monoethanolamides such as MEA cocamide; coconut fatty acid diethanolamides, fatty alcohol ethoxylates (alkylpolyethylene glycols); alkylphenol polyethylene glycols; alkyl mercaptan polyethylene glycols; fatty amine ethoxylates (alkylaminopolyethylene glycols); fatty acid ethoxylates (acylpolyethylene glycols); polypropylene glycol ethoxylates (for example, PLURONIC ™ block copolymers commercially available from BASF); fatty acid alkylolamides, (polyethylene glycolamides of fatty acids); Fatty acid N-alkyl, N-alkoxypolyhydroxyamides; sucrose esters; sorbitol esters; polyglycol ethers and their combinations. Non-ionic surfactants can be included in any desired amount. In one embodiment, nonionic surfactants are present in the composition in an amount of 0 to 3% by weight. In one embodiment, nonionic surfactants are present in the composition in an amount of from 0.5 to 1.5% by weight.

The composition may also include cationic surfactants. Examples of cationic surfactants include, but are not limited to, any compounds of quaternium or polyquaternium. Cationic surfactants may be included in any desired amount. In one embodiment, cationic surfactants are present in the composition in an amount of from 0 to 2% by weight. In one embodiment, cationic surfactants are present in the composition in an amount of from 0.1 to 0.3% by weight.

A large number of additional surfactants are described in McCutcheon's Detergents and Emulgators (1989) and other reference materials that are well known to those skilled in the art.

In one embodiment, the surfactant is a combination of an anionic surfactant and an amphoteric surfactant. In one embodiment, the surfactant comprises C10-C16 alcohol ethoxylate and cocamidopropyl betaine. In one embodiment, the alcohol ethoxylate is C10-C16 sodium alcohol ethoxylate.

When the composition is a disinfectant, the composition may contain an alcohol, such as ethanol. The disinfectants can be thickened with any substance to obtain the desired viscosity of the disinfectant composition. Examples of thickening agents include, but are not limited to, synthetic thickening agents, polymeric gums, polysaccharides, pectin, alginate, arabinogalactan, carrageenan, gellan gum, xanthan gum, guar gum, ramsan gum, furcellaran gum and other natural gums. The synthetic thickening agent in one embodiment is polyacrylate. One aqueous solution of acrylate is produced by Lubrizol in the form of CARBOPOL ™ resins, also known as CARBOMER ™, which are hydrophilic, high molecular weight crosslinked acrylic acid polymers. In one embodiment, the polymer is CARBOPOL ™ Aqua SF-1. Other polymers that can be used include, but are not limited to, CARBOPOL ™ Aqua 30, CARBOPOL ™ 940 with a molecular weight of approximately 4,000,000, and CARBOPOL ™ 934 with a molecular weight of approximately 3,000,000. Thickeners can be used individually or in combination. The amount of thickening agent may be any that provides the desired level of thickening. In one embodiment, the thickening agent is present in the composition in an amount of from 0.01 to 15% by weight. In other embodiments, the amount of thickening agent is from 1% to 10%.

The composition may also contain glycerin. Glycerin can be included in any desired amount. In one embodiment, the amount of glycerol is up to 5% by weight. Glycerin can change skin sensations after washing. At high pH, the skin feels tight after washing.

In other embodiments, the composition may comprise particulate matter. An example of a particulate matter is shea butter granules, such as ISP Corp. Butyrospermum Parkii granules, available as CAPTIVATES ™ 2485.

The composition may further comprise a colorant to correct the color of the composition to any desired color. The dye can work in combination with an indicator in order to ensure the color of the composition. Even in the presence of dye, the indicator still works to change the color of the composition with a change in pH.

Examples of dyes include, but are not limited to, annatto, caramel, carmine, β-carotene, bismuth citrate, disodium EDTA-copper, potassium-sodium-copper-chlorophyllin (chlorophyllin Cu complex), dihydroxyacetone, bismuth oxychloride, guaiazulene, henna, iron oxides , ammonium ferrocyanide iron, ferrocyanide iron, chromium green hydroxide, chromium oxide green, guanine, lead acetate, pyrophyllite, miku, silver, titanium dioxide, aluminum powder, bronze powder, copper powder, ultramarines, violet manganese, zinc oxide, luminescent sul Zinc Feed, D&C Black No. 2, D&C Black No. 3, FD&C Blue No. 1, D&C Blue No. 4, D&C Brown No. 1, FD&C Green No. 3, D&C Green No. 5, D&C Green No. 6, D&C Green No. 8, D&C Orange No. 4, D&C Orange No. 5, D&C Orange No. 10, D&C Orange No. 11, FD&C Red No. 4, D&C Red No. 6, D&C Red No. 7, D&C Red No. 17, D&C Red No. 21, D&C Red No. 22, D&C Red No. 27, D&C Red No. 28, D&C Red No. 30, D&C Red No. 31, D&C Red No. 33, D&C Red No. 34, D&C Red No. 36, FD&C Red No. 40, D&C Violet No. 2, Ext. D&C Violet No. 2, FD&C Yellow No. 5, FD&C Yellow No. 6, D&C Yellow No. 7, Ext. D&C Yellow No. 7, D&C Yellow No. 8, D&C Yellow No. 10, and D&C Yellow No. 11. In one embodiment, FD&C Blue # 1 is used as a second colorant in compositions comprising a litmus or carmine acid as an indicator. In this embodiment, Blue # 1 is present as 0.003% by weight.

The composition may be formulated with any desired viscosity. In some embodiments, the composition has a Brookfield viscosity greater than 0 to 35,000 mPa · s (cP). In one embodiment, the viscosity is less than about 14,000 mPa · s (cP), so that it can be pumped. In other embodiments, the implementation of the viscosity is more than 2500 to 14000 MPa · s (SP). Brookfield viscosity is measured on a DVII viscometer with a shaft of 5 at 20 rpm for 1 minute.

In some embodiments, the composition is formulated as a low viscosity foaming hand wash. The range of foaming liquid hand soap is approximately 25 ± 15 mPa · s (cP). Brookfield viscosity is measured on a DVII viscometer with a shaft of 3 at 100 rpm for 1 minute.

The composition can also be used in a manner including:

a) applying the composition to a substrate; and

b) leaving the composition on a substrate until a color change is observed.

The color change can be used to show that enough time has passed for the composition to work as intended (such as cleaning or disinfection) or that the composition is no longer active.

In one embodiment, the method includes:

a) applying the composition to the hands;

b) rubbing hands with each other until there is a change in color; and

c) rinsing hands with water.

The color indicator of the composition of this invention is suitable as an additive to materials such as toiletries, including, but not limited to, cleaners, body wash, shower gels, liquid hand soap, bar soap, shampoos, conditioners, and disinfectants. The present invention can be used in many places, including, but not limited to, private homes, hospitals, workplaces, childcare centers, nursing homes, schools, restaurants, airports, food establishments and food industry institutions and the like.

SPECIFIC EMBODIMENTS FOR CARRYING OUT THE INVENTION

The invention is further described in the following examples. The examples are fully illustrative and in no way limit the scope of the described and claimed invention. In the examples, the amounts of substances are based on the weight provided.

EXAMPLE 1

A liquid hand soap was prepared by mixing the following ingredients. The values shown below are based on the quantity provided. The pH of the composition is adjusted to approximately 9.5 with sodium hydroxide. 0.5% litmus by weight provides approximately 15 to 20 seconds for color change when used when washing hands.

Material Amount (% weight) Deionized water How much is needed (about 58) Dehydrated Sodium Sulfate 0.09 DMDM hydantoin 0.4 Sodium Ethoxylate Alcohol (C10-C16) (Stepan Steol CS-230) (27.5%) 29.9 Cocamidopropyl Betaine 6 Ethylene diamine tetraacetate (39% solution) 0.26 PEG-120 premix (6.9% PEG-120 methylglucose dioleate, 1% DMDM hydantoin and 92.1% water) 2.2 PEG-7 glyceryl cocoate 0.01 Perfume 0.4 Citric acid (50% solution) 0,03 Glycerol 2 Sodium ascorbate 0.25 Benzophenone-4 0.05 Litmus 0.5

EXAMPLE 2

The composition in Example 1 was used in a comparative analysis for compositions without antioxidants, only with sodium ascorbate, only with benzophenone and with a combination of sodium ascorbate and benzophenone-4. The amount of water has been adjusted to obtain 100% of the composition. The compositions were stored for 13 weeks at 49 ° C. At the very beginning, after 4 weeks, after 8 weeks and after 13 weeks, the stability of the compositions was measured using the UV and visible spectrometry method described above at 590 nm. The results are shown in the table below. The percentage change is calculated as (initial value - value at 13 weeks) / (initial value).

Litmus at a concentration of 0.5% after 13 weeks of storage at 49 ° C The absorbance at 590 nm Initial 4 weeks 8 weeks 13 weeks % change Antioxidant free 2,345 2,179 1,755 1,818 22.5% Sodium Ascorbate (0.25%) 2,273 1,981 1,525 1,527 32.8% Benzophenone-4 (0.05%) 2,317 2,009 1.7 1,543 33.4% Sodium ascorbate (0.25%) and benzophenone-4 (0.05%) 2,478 2,385 2,045 2.17 12.4%

As you can see, sodium ascorbate and benzophenone-4 separately for given amounts do not provide the level of stability that is achieved by their combined combination.

Claims (15)

1. The composition for changing colors in a cleansing composition, which contains:
but. at least one indicator selected from litmus and carminic acid,
b. a light stabilizer containing sodium ascorbate, and
from. antioxidant containing benzophenone-4. 2. The composition according to claim 1, where the composition has a second value of light absorption after 13 weeks at 49 ° C, which differs by no more than 20% from the first value of light absorption, measured initially in the test with a spectrometer in the UV and visible spectral regions for the absorption peak indicator. 3. The composition according to claim 1, where the indicator is present in an amount of from 0.01 to 10% by weight. 4. The composition according to claim 1, where the light stabilizer is present in an amount of from 0.01 to 1% by weight. 5. The composition according to claim 1, where the antioxidant is present in an amount of from 0.01 to 0.1% by weight. 6. The composition according to claim 1, additionally containing a surfactant. 7. The composition according to claim 1, which contains, wt.%:
but. from 0.01 to 1 litmus,
b. from 0.05 to 1 sodium ascorbate and
from. from 0.05 to 0.1 benzophenone-4. 8. The composition according to claim 1, which contains, wt.%:
but. about 0.5 litmus,
b. approximately 0.25 sodium ascorbate and
C. about 0.05 benzophenone-4. 9. The composition according to claim 1, additionally containing glycerin. 10. The composition according to claim 1, which contains, wt.%:
but. from 0.01 to 1 litmus,
b. from 0.05 to 1 sodium ascorbate,
from. from 0.05 to 0.1 benzophenone-4 and further comprises
d. glycerin in an amount up to 5 and
e. surfactant. 11. A method that includes:
but. applying the composition according to claim 1 to the skin and
b. leaving the composition on the skin until a color change is observed. 12. The method according to claim 11, where:
but. applying the composition to hands;
b. leaving the composition on the skin involves rubbing the hands together until a color change is observed, and rinsing the hands with water. 13. The method according to claim 11, where the composition changes from an alkaline composition to an acidic composition during use. 14. The method according to claim 11, where the color change is observed up to approximately 30 C. 15. The method according to claim 11, where the color change is observed in the period from 10 to 30 s.