KR102294241B1 - Composition for antioxidant, whitening or anti-inflammation containing persimmon core extracts as an active ingredient - Google Patents

Abstract

The present invention relates to a cosmetic composition for antioxidant, whitening, or anti-inflammation containing persimmon wick extract as an active ingredient, and has excellent DPPH and ABTS radical scavenging activity and reducing power, increases SOD activity, an antioxidant enzyme, and lipid peroxidation It has excellent antioxidant effect by significantly reducing the product MDA. In addition, it has an excellent whitening effect by significantly inhibiting intracellular tyrosinase activity and melanin synthesis, and has an anti-inflammatory effect by inhibiting the production of NO and inflammatory cytokines (TNF-α, IL-6).
Therefore, the persimmon core extract can be used as an active ingredient in a cosmetic composition for antioxidant, whitening, or anti-inflammatory.

Description

Composition for antioxidant, whitening or anti-inflammation containing persimmon core extracts as an active ingredient}

The present invention relates to an antioxidant, whitening or anti-inflammatory composition containing persimmon wick extract as an active ingredient.

The market size of dried snacks has been continuously growing in recent years as the well-being trend spreads and the popularity of modern people who value health and convenience increases. According to this trend, persimmons are mainly dried and processed and consumed as dried persimmons in the form of dried persimmons or dried persimmons. A large amount of by-products generated during the production of dried persimmons and dried persimmons are partially used as feed, but a significant amount is discarded. These by-products are becoming a problem of environmental pollution such as odor and acidification of the soil due to acetic acid fermentation during the disposal process. Nationwide, more than 100,000 tons of persimmons are produced as dried processed products annually, mainly in Gyeongsangbuk-do, and 20% of the by-products are generated in this process. Most of the research on persimmon by-products is focused on the rind and stem, and the use of the wick is insufficient. The wick is mainly removed when mechanically peeling persimmons during manufacturing.

Meanwhile, the demand for persimmons is continuously growing, and the persimmon core, a by-product, is also increasing with the increase in persimmon production every year. is presumed to be

On the other hand, in the cosmetic field, there is a trend toward favoring cosmetics containing functionalities such as whitening, UV protection, and wrinkle improvement. As the degree of preference for the product has increased, research on natural substances is being actively carried out. As of 2016, the production of functional cosmetics was about 4.4 trillion won, and it is expected to continue to grow to 15.2% of the total cosmetics production.

Therefore, in the present invention, the discarded persimmon wick was used as a raw material for natural cosmetics.

Domestic Patent Publication No. 10-2016-0125019

An object of the present invention is to provide a cosmetic composition for antioxidant, whitening, or anti-inflammatory containing persimmon wick extract as an active ingredient.

Another object of the present invention is to provide a quasi-drug composition for antioxidant, whitening, or anti-inflammatory containing persimmon wick extract as an active ingredient.

In order to achieve the above object, in one aspect, the present invention provides a cosmetic composition for antioxidant, whitening, or anti-inflammatory containing persimmon wick extract as an active ingredient.

The term persimmon core of the present invention is a by-product of persimmon fruit that is opened in the persimmon tree ( Diospyros kaki ), which is known to cause constipation, and is a part that is not ingested and discarded. The persimmon tree is one of the subtropical fruit trees cultivated in Korea. The persimmon tree is easy to cultivate and manage, yields high, and the quality and nutritional value of its fruits are very high. Therefore, persimmon trees can be planted on vacant land, including hillsides, and around houses, to increase the land use rate, and have great significance as a garden fruit tree. Persimmons contain a lot of nutrients, so they are used to make fresh fruits and processed products, including dried persimmons, and persimmon leaves are used as dimensioning agents.

In the present invention, the cosmetic composition may be applied to the extraction of dried persimmon wick, or dried and crushed persimmon wick and powdered may be applied to extraction.

As used herein, the term "extract" refers to an extract obtained by extraction treatment, a diluted or concentrated liquid of the extract, a dried product obtained by drying the extract, a prepared or purified product of the extract, or a mixture thereof, such as the extract itself and the extract Contains extracts of all formulations that can be formed using

In the present invention, drying of the extract may be carried out by a known method as long as useful components are not destroyed from the harvested plant, for example, by a method of natural drying in the shade, or may be carried out in a dry oven. In addition, crushing or pulverization can be pulverized by crushing or pulverizing to an extent that useful components of plants can be sufficiently extracted in the subsequent extraction process. The drying, crushing, or pulverizing processes may be performed in reverse order or repeated if necessary.

In the extraction of the present invention, the extraction method is not particularly limited, and extraction may be performed according to a method commonly used in the art.

In the present invention, the extract of persimmon wick _{may be obtained by extraction with water, C 1} to C ₄ lower alcohol or a mixed solvent thereof. In addition, the lower alcohol may be ethanol or methanol.

In addition, in the present invention, the term "active ingredient" means a component that can exhibit the desired activity alone or can exhibit activity together with a carrier that is not itself active.

In the present invention, the term "antioxidant" refers to the action of inhibiting oxidation, in the human body, a prooxidant and an antioxidant are in balance, but this balance is caused by various factors. If the imbalance is achieved and the oxidative stress is induced, potential cellular damage and pathological diseases are caused. Reactive oxygen species (ROS), which is a direct cause of oxidative stress, is unstable and highly reactive, so it easily reacts with various biomaterials and attacks the body's polymers to cause irreversible damage to cells and tissues. NO, HNO ₂ , ONOO ^- such as reactive nitrogen species (RNS), and reactive oxygen species such as ROS oxidize and destroy cells in the body, thereby exposing them to various diseases.

The antioxidant refers to the function of inhibiting the oxidation of cells by free radicals or reactive oxygen species (ROS), which are highly reactive according to oxidative stress caused by intracellular metabolism or ultraviolet rays, It involves the removal of free radicals or reactive oxygen species, thereby reducing damage to cells.

In one embodiment of the present invention, persimmon wick ethanol extract increased DPPH and ABTS radical scavenging activity and reducing power in a concentration-dependent manner, increased intracellular antioxidant enzyme SOD activity, and significantly inhibited MDA, a lipid peroxidation product, It was confirmed that the antioxidant effect was excellent.

In addition, the term "whitening" used in the present invention refers to a method of increasing the brightness of the skin whose brightness has been reduced due to an excess of pigments such as melanin, or maintaining the brightness of the skin at a certain level, and increasing the brightness formed by the method As meant to encompass the aged skin, etc., it may specifically mean skin whitening. "Skin whitening" is understood as a result of inhibiting the production of melanin, specifically, as the production of melanin is inhibited, it can be understood as an improvement in symptoms resulting from an increase in melanin, such as melasma, freckle improvement, skin aging, etc. have.

In one embodiment of the present invention, it was confirmed that the ethanol extract of persimmon core significantly inhibited intracellular tyrosinase activity and melanin synthesis, which play an important role in the biosynthesis of melanin pigment, and thus had an excellent whitening effect.

In the present invention, the term "anti-inflammatory" refers to inhibiting inflammation, and the inflammation is one of the defense responses of a living tissue to a certain stimulus. say More specifically, inflammation is part of innate immunity, and as in other animals, human innate immunity recognizes patterns on the surface of cells that are specific to pathogens. Phagocytes recognize cells with such a surface as non-self and attack pathogens. If pathogens break through the body's physical barriers, an inflammatory response occurs. The inflammatory response is a non-specific defense action that creates a hostile environment for microorganisms that invade the wound site. In the inflammatory response, when there is a wound or an external infectious agent enters the body, the white blood cells responsible for the early stage immune response flock to and express cytokines. Therefore, the expression level of intracellular cytokines is an indicator of inflammatory response activation. The anti-inflammatory of the present invention may be to inhibit inflammation occurring in the skin.

In one embodiment of the present invention, persimmon wick extract has no toxicity to Raw264.7 cells induced by LPS, reduces NO production and reduces the secretion of inflammatory cytokines TNF-α, IL-6, It was confirmed that there was an inflammatory effect.

The antioxidant, whitening, or anti-inflammatory composition of the present invention is a compound known to have antioxidant, whitening, or anti-inflammatory effects so as to enhance or reinforce antioxidant, whitening, or anti-inflammatory effects, in addition to the active ingredient, persimmon wick extract. or natural extracts.

On the other hand, in the cosmetic composition for antioxidant, whitening, or anti-inflammatory of the present invention, the active ingredient may be used in an arbitrary amount (effective amount) according to use, formulation, purpose of formulation, etc. as long as it can exhibit antioxidant, whitening, or anti-inflammatory activity. It may be included, and a typical effective amount may be included within the range of 0.001 weight % to 99.99 weight % based on the total weight of the composition. Here, "effective amount" refers to the amount of an active ingredient capable of inducing antioxidant, whitening, or anti-inflammatory effects. Such effective amounts can be determined empirically within the ordinary ability of one of ordinary skill in the art.

The cosmetic composition for antioxidant, whitening, or anti-inflammatory of the present invention may be prepared in various forms, for example, the cosmetic composition of the present invention may be prepared in any formulation conventionally prepared in the art, for example, a solution , external ointment, cream, foam, nourishing lotion, softening lotion, pack, soft water, emulsion, makeup base, essence, liquid detergent, bath agent, sunscreen cream, sun oil, suspension, emulsion, paste, gel, lotion, powder , soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, patch, and spray, but is not limited thereto.

In the present invention, the cosmetic composition may have a cream formulation, and the cream formulation is prepared by heating an aqueous layer and an oil phase after heating and mixing at a low temperature. One or more selected from the group consisting of rose floral water, neroli water, rosemary water and glycerin may be used as the aqueous layer constituting the cream, and camellia oil, macadamia oil, avocado oil, jojoba oil, rosehip oil, At least one selected from the group consisting of setar alcohol, emulsified wax, cypress oil, and grapefruit oil may be used. As the natural preservative, an extract of Mokdanpi or grapefruit seeds may be used.

The rose floral water, neroli water, and rosemary water constituting the aqueous layer are a kind of floral water and contain a large amount of water-soluble substances of plants as condensed water obtained in the process of distilling and extracting essential oil. Glycerin constituting the aqueous layer is extracted from coconut, has a moisturizing effect, and is stable enough to be used as a food additive. Setar alcohol constituting the oil phase is an alcohol extracted from coconut, and it aids in emulsification during cream production, and has stabilization, viscosity control, and moisturizing effects.

The cosmetic composition for antioxidant, whitening, or anti-inflammatory of the present invention may include an acceptable carrier in the cosmetic preparation in addition to the active ingredient thereof. Herein, "acceptable carrier for cosmetic preparations" refers to compounds or compositions that are already known and used that can be included in cosmetic preparations, or compounds or compositions to be developed in the future that do not have toxicity, instability, or irritation beyond what the human body can adapt to when in contact with the skin. say that The carrier is included in the antioxidant, whitening, or anti-inflammatory cosmetic composition of the present invention in an amount of from about 1% to about 99.99% by weight, preferably from about 5% to about 99% by weight of the total weight of the composition. may be included. However, since the above ratio varies depending on the formulation of the cosmetic of the present invention and its specific application site (face or hand) or its desired application amount, the above ratio is intended to limit the scope of the present invention in any aspect. should not be understood

On the other hand, as the carrier, alcohol, oil, surfactant, fatty acid, silicone oil, humectant, humectant, viscosity modifier, emulsion, stabilizer, sunscreen, color developer, fragrance, and the like may be exemplified. Alcohols, oils, surfactants, fatty acids, silicone oils, humectants, humectants, viscosity modifiers, emulsifiers, stabilizers, sunscreens, coloring agents, perfumes, etc. that can be used as the carrier are already known in the art. Therefore, those skilled in the art can select and use an appropriate material/composition.

As another aspect, the present invention provides an antioxidant, whitening, or anti-inflammatory quasi-drug composition containing a persimmon core extract as an active ingredient.

In the present invention, persimmon wick extract, antioxidant, whitening and anti-inflammatory as described above.

The term "quasi-drug" as used in the present invention refers to items with a milder action than pharmaceuticals among items used for the purpose of diagnosing, treating, improving, alleviating, treating or preventing diseases of humans or animals, for example, in the Pharmaceutical Affairs Act. According to the report, quasi-drugs exclude products used for pharmaceutical purposes, and include products used for the treatment or prevention of diseases in humans and animals, and products with minor or no direct action on the human body.

The quasi-drug composition of the present invention is a body cleanser, disinfectant cleaner, detergent, kitchen cleaner, cleaning agent, toothpaste, gargle, wet tissue, detergent, soap, hand wash, hair cleaner, hair softener, humidifier filler, mask, ointment and filter filler. It may be prepared in a formulation selected from the group consisting of, but is not limited thereto.

When the composition of the present invention is included in a quasi-drug for anti-oxidation, whitening, or anti-inflammatory purposes, the composition may be used as it is or used together with other quasi-drug components, and may be appropriately used according to a conventional method. The mixing amount of the active ingredient may be appropriately determined according to the purpose of use, and the quasi-drug composition according to the present invention may contain the persimmon core extract in an amount of 0.01 to 20% by weight based on the total weight of the composition.

The present invention relates to a cosmetic composition for antioxidant, whitening, or anti-inflammation containing persimmon wick extract as an active ingredient, and has excellent DPPH and ABTS radical scavenging activity and reducing power, increases SOD activity, an antioxidant enzyme, and lipid peroxidation It has excellent antioxidant effect by significantly reducing the product MDA. In addition, it has an excellent whitening effect by significantly inhibiting intracellular tyrosinase activity and melanin synthesis, and has an anti-inflammatory effect by inhibiting the production of NO and inflammatory cytokines (TNF-α, IL-6). In addition, it does not contain ingredients harmful to the human body and is made of natural ingredients, so it can be used as a natural cosmetic.

Therefore, the persimmon core extract can be used as an active ingredient in a cosmetic composition for antioxidant, whitening, or anti-inflammatory.

1 shows a process for preparing an ethanol extract of persimmon wick according to the present invention.
Figure 2 shows the antioxidant effect of persimmon core ethanol extract according to the present invention.
Figure 3 shows the antioxidant effect of the ethanol extract of persimmon core according to the present invention.
4 shows the intracellular antioxidant effect of the ethanol extract of persimmon wick according to the present invention.
5 shows the anti-inflammatory effect of persimmon core ethanol extract according to the present invention.
6 shows the whitening effect of the ethanol extract of persimmon core according to the present invention.
7 is a sensory evaluation result for each formulation of the cream.
8 is a sensory evaluation result of a cream containing an ethanol extract of persimmon core.
9 is a temperature stability evaluation result of a cream containing an ethanol extract of persimmon core.
10 is a formulation stability evaluation result of a cream containing an ethanol extract of persimmon core.
11 is a result of stability evaluation for microorganisms of a cream to which an ethanol extract of persimmon core is added.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those of ordinary skill in the art can easily carry out the present invention. However, the present invention may be embodied in many different forms and is not limited to the embodiments described herein.

Example 1: Preparation of persimmon wick ethanol extract

Dried persimmon wick (40 g) was immersed in 95% ethanol (1 L) and extracted for 24 hours, followed by filtration sterilization, vacuum concentration, and freeze-drying.

Example 2: Evaluation of antioxidant effect

2-1: Evaluation of total polyphenol and total flavonoid content

The contents of polyphenols and flavonoids in the ethanol extract of persimmon core prepared in Example 1 were measured using the Folins-Denis method and the Davis method, and are shown in Table 1. As a result, the extract of persimmon core (40 g) contained about 786 g of total polyphenols and about 31 g of total flavonoids.

2-2: Evaluation of DPPH and ABTS radical scavenging ability

The DPPH and ABTS radical scavenging ability of the ethanol extract prepared in Example 1 was measured using the Blois method and the Roberta method. As a result, it was confirmed that the DPPH and ABTS radical scavenging ability increased as the concentration of the persimmon wick ethanol extract increased, confirming that the antioxidant effect increased in a concentration-dependent manner (FIG. 2).

2-3: FRAP and Reducing power

The reducing power of the ethanol extract prepared in Example 1 was measured using the Blois method and the Roberta method. As a result, it was confirmed that the reducing power increased as the concentration of the persimmon wick ethanol extract increased, confirming that the antioxidant effect increased in a concentration-dependent manner (FIG. 3).

2-4: Evaluation of intracellular antioxidant effect

After processing persimmon wick ethanol extract in brain hippocampal cells (HT22), formazan generated by the addition of MTT reagent was measured at 570 nm using a microplate reader to measure cell viability. In addition, SOD (superoxide dismutase) activity, an intracellular antioxidant enzyme, and MDA (malondialdehyde) level, a lipid peroxidation product, were measured.

As a result, it was confirmed that the viability of HT22 cells induced by oxidative stress was decreased by the hydrogen peroxide treatment, but the cell viability of HT22 cells was recovered by the treatment with the ethanol extract of persimmon core (FIG. 4).

In addition, it was confirmed that the intracellular SOD activity and MDA level were decreased by the treatment of the ethanol extract from persimmon core in HT22 cells induced by oxidative stress, thereby confirming the intracellular antioxidant effect of the ethanol extract of persimmon core (Fig. 4). .

Example 3: Evaluation of anti-inflammatory effect

After treating macrophage cells (Raw264.7) with ethanol extract of persimmon wick, the formazan generated by the addition of MTT reagent was measured at 570 nm using a microplate reader to measure cell viability. In addition, LPS-induced macrophage cells (Raw264.7) were treated with persimmon wick ethanol extract and the supernatant was collected, and the secretion ability of inflammatory cytokines (TNF-α, IL-6) was measured using an ELISA kit. . In addition, the concentration of nitric oxide was measured by reacting the supernatant with Griess reagent.

As a result, it was confirmed that the persimmon wick ethanol extract had no toxicity to Raw 264.7 cells, inhibited nitric oxide (NO) production in a concentration-dependent manner, and inhibited the production of inflammatory cytokines (FIG. 5). Accordingly, it was found that the ethanol extract of persimmon core had an anti-inflammatory effect.

Example 4: Evaluation of whitening effect

Melanoma cells (B16F10) were treated with ethanol extract of persimmon wick and the formazan generated by the addition of MTT reagent was measured at 570 nm using a microplate reader to measure cell viability.

In order to evaluate the tyrosinase inhibitory activity using melanoma cells (B16F10), the persimmon core was treated with ethanol extract and then IBMX was treated to promote melanin production. Cells were quantified using a BCA protein detection kit, and 1 N NaOH was added to measure the degree of melanin synthesis.

In addition, by measuring the amount of DOPA chrome produced by reacting the cells with L-DOPA and the supernatant, the tyrosinase inhibitory activity was measured.

As a result, it was confirmed that the persimmon core ethanol extract was not toxic to melanoma cells (B16F10), the tyrosinase inhibitory activity was increased in a concentration-dependent manner by the persimmon core ethanol extract treatment, and the melanin inhibitory effect was also increased in a concentration-dependent manner ( Fig. 6).

Example 5: Evaluation of suitability of natural functional cosmetic formulations using persimmon core ethanol extract

5-1: Preparation of primary cream (base)

Five types of base cream were prepared with reference to the existing natural cosmetic manufacturing method. The aqueous layer and the oil phase were respectively heated and mixed at a low temperature, and when a cream was formed, a natural preservative was added to prepare a cream. As the aqueous layer, rose floral water, neroli water, and glycerin were used. As the oil phase, camellia oil, macadamia oil, avocado oil, jojoba oil, rosehip oil, setar alcohol, emulsified wax, cypress oil, and grapefruit oil were used. As natural preservatives, mulberry bark and grapefruit seeds were extracted and purified and used as preservatives. The formulation components prepared as the primary cream are shown in Table 2.

5-2: First Cream Evaluation

The sensory evaluation was performed on the completed base cream for college students in their 20s. Fragrance, color, and application color values ranged from 1-5. As a result, as shown in FIG. 7 , in the case of Formulation No. 4 cream, the spreadability was good, and in the case of Formulation No. 5 cream, the fragrance was good ( FIG. 7 ).

5-3: Secondary cream preparation

A new cream base form was prepared by combining the spreadability of the formulation No. 4 cream with good evaluation results and the fragrance of the No. 5 cream. The aqueous layer of Cream Base No. 4, which was evaluated as having the best spreadability, was replaced with Neroli water, and grapefruit oil, the fragrance component of Cream No. 5, which had the best scent, was added. As natural preservatives, mulberry bark and grapefruit seeds were extracted and purified and used. Specific formulation components of the secondary cream are shown in Table 3. Rose floral water was replaced with neroli water for fragrance, and glycerin was added for spreadability.

Thereafter, 10 g of the cream of Formulation 6 prepared in Table 3 was taken and 1 g of persimmon paper extract (stock: 1 mg/ml) was added to complete the persimmon core cream consisting of a total formulation of 11 g. Therefore, it was attempted to compare Formulation No. 6 without persimmon paper extract and Formulation No. 7 containing persimmon paper extract through the experiment below.

formulation Formulation No. 6 Content (g) Persimmon paper extract (g) Total (g) number 7 10 One 11

5-4: Secondary Cream Evaluation

As shown in Table 4, a sensory evaluation was performed on college students in their early twenties by comparing the texture, spreadability, fragrance, stickiness, and absorption power of commercial products using creams containing ethanol extract of persimmon core. The texture, spreadability, fragrance, stickiness, and absorbency values were expressed in the range of 1-5.

As a result, as shown in FIG. 8 , in the case of the cream containing the persimmon core extract, the spreadability and fragrance were better than that of the commercial company I product, and the stickiness was evaluated as low, and thus the preference was evaluated ( FIG. 8 ). .

Example 6: Safety evaluation method and results of ethanol extract cosmetics from persimmon core

6-1: Storage test (temperature stability evaluation)

After storing the persimmon core ethanol extract cosmetic (Formulation No. 7) prepared in Example 5-3 at -18°C, 4°C, 25°C, and 40°C for about 2 weeks, the scent, color, viscosity, and degree of separation of the cream by temperature , the degree of change in the emulsification state was confirmed.

As a result, as shown in FIG. 9 , in the group with the addition of persimmon core ethanol extract (Formulation No. 7), as shown in FIG. 9 , discoloration, discoloration, and cream formulation even after 2 weeks (after) compared to 2 weeks before (formulation No. 7) It was confirmed that the separation did not occur.

6-2: pH measurement

To determine whether the persimmon core cream (Formulation No. 7) added with persimmon core ethanol extract corresponds to the appropriate cosmetic pH range, 15 ml of a diluted solvent PBS and 1 ml of persimmon core cream were mixed to measure the pH. As a result, the pH of the cream was 6.68±0.16. It was within the range of 6-7, which is the appropriate cream pH.

6-3: Formulation stability evaluation

The stability of the cream formulation was evaluated by centrifuge for 30 minutes at 3000rpm and sonication for 1 hour with persimmon core cream (formulation No. 7) added with ethanol extract of persimmon core.

As a result, as shown in FIG. 10 , it was confirmed that the cream formulation did not separate and thus formulation stability was high.

6-4: Cosmetic microorganism limit test

Plate count agar, Photato dextrose argar, and Lactose broth medium were used to detect common bacteria, common fungi, and E. coli contamination by pre-treatment with persimmon core cream (Formulation No. 7) with ethanol extract of persimmon core. As a result of dispensing 1 ml of the sample and culturing at 37° C. for 24 hours, colonies of general bacteria and fungi were not formed, as shown in FIG. 11, and bubbles were not formed in the Duram tube. was confirmed. In the microbial limit test, general bacteria and general fungi specified in the cosmetic microbial limit test method were used.

As seen above, persimmon core ethanol extract increased DPPH and ABTS radical scavenging activity and reducing power in a concentration-dependent manner, increased SOD activity, an intracellular antioxidant enzyme, and significantly inhibited MDA, a lipid peroxidation product, to have antioxidant effects was confirmed to be excellent. It was confirmed that the persimmon wick ethanol extract had anti-inflammatory effects by reducing the secretion of inflammatory cytokines and NO while not being toxic to Raw264.7 cells induced by LPS. In addition, it was observed to significantly inhibit intracellular tyrosinase activity and melanin synthesis, which play an important role in the biosynthesis of melanin pigment.

In addition, as a result of discoloration, odor, formulation separation confirmation, pH measurement, formulation stability test, and microbial limit test according to the temperature change of the cream containing persimmon core ethanol extract for commercialization, no discoloration, discoloration, or change in the formulation occurred, and the cosmetic pH was appropriate. It was confirmed that it met the standards and was safe as no microorganisms were detected.

Through the present invention, the problems caused by cosmetics containing harmful ingredients have been solved, and the advantages of natural cosmetics are maximized by adding natural ingredient extracts, and the possibility of developing natural functional cosmetics using ethanol extract from persimmon core and minimizing irritation to the skin is increased. could check

Claims (6)

A cosmetic composition for whitening containing persimmon core ethanol extract as an active ingredient. delete delete According to claim 1,
The cosmetic composition,
Solution, external ointment, cream, foam, nourishing lotion, softening lotion, pack, soft water, emulsion, makeup base, essence, liquid detergent, bath agent, sunscreen cream, sun oil, suspension, emulsion, paste, gel, lotion, A cosmetic composition for whitening, characterized in that it has a formulation selected from the group consisting of powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, patch and spray. According to claim 1,
The cosmetic composition,
A cosmetic composition for whitening, characterized in that it has a cream formulation. delete

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