RU2462464C2 - Замещенные сульфамидные производные - Google Patents

Info

Publication number

RU2462464C2

RU2462464C2 RU2009115960/04A RU2009115960A RU2462464C2 RU 2462464 C2 RU2462464 C2 RU 2462464C2 RU 2009115960/04 A RU2009115960/04 A RU 2009115960/04A RU 2009115960 A RU2009115960 A RU 2009115960A RU 2462464 C2 RU2462464 C2 RU 2462464C2

Authority

RU

Russia

Prior art keywords

methoxy

piperidin

ethanone

dimethylphenylsulfonyl

piperazin

Prior art date

2006-09-29

Links

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• Global Dossier
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• NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical class NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 title claims abstract 15
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract 6
• 102000017916 BDKRB1 Human genes 0.000 claims abstract 5
• 108060003359 BDKRB1 Proteins 0.000 claims abstract 5
• 239000002253 acid Substances 0.000 claims abstract 3
• 150000007513 acids Chemical class 0.000 claims abstract 3
• 239000000203 mixture Substances 0.000 claims abstract 3
• 150000003839 salts Chemical class 0.000 claims abstract 3
• 238000000034 method Methods 0.000 claims abstract 2
• -1 benzooxadiazolyl Chemical group 0.000 claims 261
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 130
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 20
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 19
• 125000000217 alkyl group Chemical group 0.000 claims 18
• IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims 16
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 16
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 16
• UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 16
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 12
• 125000004574 piperidin-2-yl group Chemical group N1C(CCCC1)* 0.000 claims 11
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 10
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 9
• 125000001624 naphthyl group Chemical group 0.000 claims 8
• CJJZCWJJAZMVCJ-UHFFFAOYSA-N n-benzyl-2,5-dimethylaniline Chemical compound CC1=CC=C(C)C(NCC=2C=CC=CC=2)=C1 CJJZCWJJAZMVCJ-UHFFFAOYSA-N 0.000 claims 7
• 125000004076 pyridyl group Chemical group 0.000 claims 7
• 125000003118 aryl group Chemical group 0.000 claims 6
• 229910052739 hydrogen Inorganic materials 0.000 claims 6
• 208000002193 Pain Diseases 0.000 claims 5
• 125000004484 1-methylpiperidin-4-yl group Chemical group CN1CCC(CC1)* 0.000 claims 4
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 4
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
• 229910052799 carbon Inorganic materials 0.000 claims 4
• 125000004122 cyclic group Chemical group 0.000 claims 4
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 125000002757 morpholinyl group Chemical group 0.000 claims 4
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims 4
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 3
• 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 125000003386 piperidinyl group Chemical group 0.000 claims 3
• 125000001544 thienyl group Chemical group 0.000 claims 3
• PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims 2
• 208000000094 Chronic Pain Diseases 0.000 claims 2
• QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 claims 2
• CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims 2
• JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims 2
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 2
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
• KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
• 230000001154 acute effect Effects 0.000 claims 2
• PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims 2
• MGNZXYYWBUKAII-UHFFFAOYSA-N cyclohexa-1,3-diene Chemical compound C1CC=CC=C1 MGNZXYYWBUKAII-UHFFFAOYSA-N 0.000 claims 2
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• 125000005047 dihydroimidazolyl group Chemical group N1(CNC=C1)* 0.000 claims 2
• 125000002541 furyl group Chemical group 0.000 claims 2
• 125000001072 heteroaryl group Chemical group 0.000 claims 2
• 125000000623 heterocyclic group Chemical group 0.000 claims 2
• 208000004296 neuralgia Diseases 0.000 claims 2
• 230000002981 neuropathic effect Effects 0.000 claims 2
• 208000021722 neuropathic pain Diseases 0.000 claims 2
• 125000001424 substituent group Chemical group 0.000 claims 2
• KZKRRZFCAYOXQE-UHFFFAOYSA-N 1$l^{2}-azinane Chemical group C1CC[N]CC1 KZKRRZFCAYOXQE-UHFFFAOYSA-N 0.000 claims 1
• SLLFVLKNXABYGI-UHFFFAOYSA-N 1,2,3-benzoxadiazole Chemical compound C1=CC=C2ON=NC2=C1 SLLFVLKNXABYGI-UHFFFAOYSA-N 0.000 claims 1
• RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 1
• GKGOOILMOFKQOM-UHFFFAOYSA-N 1-(3,4-dihydro-1h-2,6-naphthyridin-2-yl)-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone;hydrochloride Chemical compound Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC3=CC=NC=C3CC2)CCCC1 GKGOOILMOFKQOM-UHFFFAOYSA-N 0.000 claims 1
• VHAUCVJHIHPFAN-UHFFFAOYSA-N 1-(3-pyridin-3-ylpyrrolidin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2C=NC=CC=2)CCCC1 VHAUCVJHIHPFAN-UHFFFAOYSA-N 0.000 claims 1
• GAZFASPAHGWFMS-UHFFFAOYSA-N 1-(3-pyridin-4-ylpyrrolidin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2C=CN=CC=2)CCCC1 GAZFASPAHGWFMS-UHFFFAOYSA-N 0.000 claims 1
• RHKZAQHGAUTORO-UHFFFAOYSA-N 1-(4-benzyl-1,4-diazepan-1-yl)-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC=CC=3)CCC2)CCCC1 RHKZAQHGAUTORO-UHFFFAOYSA-N 0.000 claims 1
• ZDWPUHLBPLODAW-UHFFFAOYSA-N 1-(4-benzyl-1,4-diazepan-1-yl)-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC=CC=3)CCC2)CCCC1 ZDWPUHLBPLODAW-UHFFFAOYSA-N 0.000 claims 1
• ULVNVZUDWUDMTK-UHFFFAOYSA-N 1-(4-benzyl-1,4-diazepan-1-yl)-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC=CC=3)CCC2)CCCC1 ULVNVZUDWUDMTK-UHFFFAOYSA-N 0.000 claims 1
• UTYRGZCTJSLTQS-UHFFFAOYSA-N 1-(4-benzyl-1,4-diazepan-1-yl)-2-[[2-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC=CC=3)CCC2)CC2=CC=CC=C2C1 UTYRGZCTJSLTQS-UHFFFAOYSA-N 0.000 claims 1
• OVUXTRAZRQORKY-UHFFFAOYSA-N 1-(4-benzylpiperazin-1-yl)-2-[[1-(2,5-dichlorothiophen-3-yl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound S1C(Cl)=CC(S(=O)(=O)N2C(CCC2)COCC(=O)N2CCN(CC=3C=CC=CC=3)CC2)=C1Cl OVUXTRAZRQORKY-UHFFFAOYSA-N 0.000 claims 1
• SFRRCJIATFQRAU-UHFFFAOYSA-N 1-(4-benzylpiperazin-1-yl)-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC=CC=3)CC2)CCCC1 SFRRCJIATFQRAU-UHFFFAOYSA-N 0.000 claims 1
• HLWZVDXQMCCUAF-UHFFFAOYSA-N 1-(4-benzylpiperazin-1-yl)-2-[[1-(4-chloro-2,5-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1=C(Cl)C(C)=CC(S(=O)(=O)N2C(CCCC2)COCC(=O)N2CCN(CC=3C=CC=CC=3)CC2)=C1C HLWZVDXQMCCUAF-UHFFFAOYSA-N 0.000 claims 1
• HMDXMZZPFPDGDD-UHFFFAOYSA-N 1-(4-benzylpiperazin-1-yl)-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC=CC=3)CC2)CCC1 HMDXMZZPFPDGDD-UHFFFAOYSA-N 0.000 claims 1
• DREQIGTWJXDODC-UHFFFAOYSA-N 1-(4-benzylpiperidin-1-yl)-2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC=3C=CC=CC=3)CC2)CCCC1 DREQIGTWJXDODC-UHFFFAOYSA-N 0.000 claims 1
• AHIKJJVWZJKDEN-UHFFFAOYSA-N 1-(4-ethylpiperazin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1CN(CC)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CCC1 AHIKJJVWZJKDEN-UHFFFAOYSA-N 0.000 claims 1
• LZILPWNGHCMHKN-UHFFFAOYSA-N 1-(4-ethylpiperazin-1-yl)-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1CN(CC)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)CCC1 LZILPWNGHCMHKN-UHFFFAOYSA-N 0.000 claims 1
• AEXAKVSCMWIFNA-UHFFFAOYSA-N 1-(4-methylpiperazin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CCCC1 AEXAKVSCMWIFNA-UHFFFAOYSA-N 0.000 claims 1
• MSDFXJCWFDBDFJ-UHFFFAOYSA-N 1-(4-morpholin-4-ylpiperidin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCOCC2)CCC1 MSDFXJCWFDBDFJ-UHFFFAOYSA-N 0.000 claims 1
• AJFKNZKYIKHHHC-UHFFFAOYSA-N 1-(4-piperidin-1-ylpiperidin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCCC2)CCC1 AJFKNZKYIKHHHC-UHFFFAOYSA-N 0.000 claims 1
• OZKZHZGDSDWQOL-UHFFFAOYSA-N 1-(4-piperidin-1-ylpiperidin-1-yl)-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCCC2)CCCC1 OZKZHZGDSDWQOL-UHFFFAOYSA-N 0.000 claims 1
• ZVMNZWVSMJJAKH-UHFFFAOYSA-N 1-(4-pyridin-4-ylpiperazin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CN=CC=2)CCC1 ZVMNZWVSMJJAKH-UHFFFAOYSA-N 0.000 claims 1
• UVLGQAGHBGDQSX-UHFFFAOYSA-N 1-(4-pyrrolidin-1-ylpiperidin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCC2)CCC1 UVLGQAGHBGDQSX-UHFFFAOYSA-N 0.000 claims 1
• LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims 1
• RDHDDBVBGKADLB-FIWHBWSRSA-N 1-[(3r)-3-(dimethylamino)pyrrolidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C[C@@H](CC2)N(C)C)CCCC1 RDHDDBVBGKADLB-FIWHBWSRSA-N 0.000 claims 1
• QNQOWXDUWRCXPB-MRTLOADZSA-N 1-[(3r)-3-(dimethylamino)pyrrolidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C[C@@H](CC2)N(C)C)CCC1 QNQOWXDUWRCXPB-MRTLOADZSA-N 0.000 claims 1
• MTDJYBHLNVJDKT-UHFFFAOYSA-N 1-[2-(5-bromopyridin-3-yl)piperidin-1-yl]-2-[[1-[3-(trifluoromethyl)phenyl]sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound FC(F)(F)C1=CC=CC(S(=O)(=O)N2C(CCCC2)COCC(=O)N2C(CCCC2)C=2C=C(Br)C=NC=2)=C1 MTDJYBHLNVJDKT-UHFFFAOYSA-N 0.000 claims 1
• SOWQZPBJILIBDL-UHFFFAOYSA-N 1-[2-(6-methoxypyridin-3-yl)piperidin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1=NC(OC)=CC=C1C1N(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CCCC1 SOWQZPBJILIBDL-UHFFFAOYSA-N 0.000 claims 1
• HOQUPGOXMYRORR-UHFFFAOYSA-N 1-[2-(piperidin-1-ylmethyl)pyrrolidin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)CN2CCCCC2)CCCC1 HOQUPGOXMYRORR-UHFFFAOYSA-N 0.000 claims 1
• JGKLGUIMQQHXKK-UHFFFAOYSA-N 1-[2-(pyridin-2-ylmethyl)pyrrolidin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)CC=2N=CC=CC=2)CCCC1 JGKLGUIMQQHXKK-UHFFFAOYSA-N 0.000 claims 1
• RKIKDVWRLZSCOB-UHFFFAOYSA-N 1-[2-[(3-methylpyridin-2-yl)methyl]piperidin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCCC2)CC=2C(=CC=CN=2)C)CCCC1 RKIKDVWRLZSCOB-UHFFFAOYSA-N 0.000 claims 1
• VOLGVSUBEKDANR-UHFFFAOYSA-N 1-[2-[(5-ethylpyridin-2-yl)methyl]piperidin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound N1=CC(CC)=CC=C1CC1N(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CCCC1 VOLGVSUBEKDANR-UHFFFAOYSA-N 0.000 claims 1
• XUCPTYRKOSKMTI-UHFFFAOYSA-N 1-[2-[(5-ethylpyridin-2-yl)methyl]pyrrolidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound N1=CC(CC)=CC=C1CC1N(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)CCC1 XUCPTYRKOSKMTI-UHFFFAOYSA-N 0.000 claims 1
• WCGDRNVDUJWAFQ-UHFFFAOYSA-N 1-[2-[4-(dimethylamino)phenyl]azepan-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCCCC2)C=2C=CC(=CC=2)N(C)C)CCCC1 WCGDRNVDUJWAFQ-UHFFFAOYSA-N 0.000 claims 1
• NWWSTGVSSRNEGB-UHFFFAOYSA-N 1-[2-[4-(dimethylamino)phenyl]azepan-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCCCC2)C=2C=CC(=CC=2)N(C)C)CCC1 NWWSTGVSSRNEGB-UHFFFAOYSA-N 0.000 claims 1
• QHGCTXCLBMGEFU-UHFFFAOYSA-N 1-[2-[4-(dimethylamino)phenyl]pyrrolidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)C=2C=CC(=CC=2)N(C)C)CCCC1 QHGCTXCLBMGEFU-UHFFFAOYSA-N 0.000 claims 1
• CYURQSTYGXZBNQ-UHFFFAOYSA-N 1-[2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetyl]piperidin-4-one Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(=O)CC2)CCCC1 CYURQSTYGXZBNQ-UHFFFAOYSA-N 0.000 claims 1
• NBYYQVPPXQKMSW-UHFFFAOYSA-N 1-[4-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CC3CCCCN3CC2)CCCC1 NBYYQVPPXQKMSW-UHFFFAOYSA-N 0.000 claims 1
• VWTBGNLZRONPGD-UHFFFAOYSA-N 1-[4-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone;dihydrochloride Chemical compound Cl.Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CC3CCCCN3CC2)CCCC1 VWTBGNLZRONPGD-UHFFFAOYSA-N 0.000 claims 1
• RDPVEYLVIFKHMD-UHFFFAOYSA-N 1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=C4OCOC4=CC=3)CC2)CCCC1 RDPVEYLVIFKHMD-UHFFFAOYSA-N 0.000 claims 1
• IBTPFUOTTWKHKR-UHFFFAOYSA-N 1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2-[[1-(3,4-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=C4OCOC4=CC=3)CC2)CCC1 IBTPFUOTTWKHKR-UHFFFAOYSA-N 0.000 claims 1
• KOIMLSCWNIVYAJ-UHFFFAOYSA-N 1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=C4OCOC4=CC=3)CC2)CCC1 KOIMLSCWNIVYAJ-UHFFFAOYSA-N 0.000 claims 1
• MKCSOGWNQOZQKO-UHFFFAOYSA-N 1-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2SC3=CC=CC=C3N=2)CCCC1 MKCSOGWNQOZQKO-UHFFFAOYSA-N 0.000 claims 1
• WBMRWBVBGRWSLJ-UHFFFAOYSA-N 1-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2SC3=CC=CC=C3N=2)CCCC1 WBMRWBVBGRWSLJ-UHFFFAOYSA-N 0.000 claims 1
• OQUQKBMEJHEDHP-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[(1-naphthalen-1-ylsulfonylpiperidin-2-yl)methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=CC=C3C=CC=2)CC1 OQUQKBMEJHEDHP-UHFFFAOYSA-N 0.000 claims 1
• NVPRLGXEMFZLHL-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[(1-naphthalen-2-ylsulfonyl-3,4-dihydro-2h-quinolin-2-yl)methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(C3=CC=CC=C3CC2)S(=O)(=O)C=2C=C3C=CC=CC3=CC=2)CC1 NVPRLGXEMFZLHL-UHFFFAOYSA-N 0.000 claims 1
• XXHJFFCJDGIJDA-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[(1-naphthalen-2-ylsulfonylpiperidin-2-yl)methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C3C=CC=CC3=CC=2)CC1 XXHJFFCJDGIJDA-UHFFFAOYSA-N 0.000 claims 1
• LLLXWOFXXXVMJT-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[(1-quinolin-8-ylsulfonylpiperidin-2-yl)methoxy]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=NC=CC=C3C=CC=2)CC1 LLLXWOFXXXVMJT-UHFFFAOYSA-N 0.000 claims 1
• QIUSCDIZSGRVGX-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[(2-naphthalen-2-ylsulfonyl-3,4-dihydro-1h-isoquinolin-3-yl)methoxy]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CC3=CC=CC=C3C2)S(=O)(=O)C=2C=C3C=CC=CC3=CC=2)CC1 QIUSCDIZSGRVGX-UHFFFAOYSA-N 0.000 claims 1
• MHUUPGKTWRGBQY-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[1-(2,4,5-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(Cl)=C(Cl)C=2)Cl)CC1 MHUUPGKTWRGBQY-UHFFFAOYSA-N 0.000 claims 1
• YOJXOJUIZJYACY-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CC1 YOJXOJUIZJYACY-UHFFFAOYSA-N 0.000 claims 1
• ULNBBNQRKHOXLA-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC1 ULNBBNQRKHOXLA-UHFFFAOYSA-N 0.000 claims 1
• KOSSXIWNGPDMGW-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[1-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonyl)piperidin-2-yl]methoxy]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C3CCCCC3=CC=2)CC1 KOSSXIWNGPDMGW-UHFFFAOYSA-N 0.000 claims 1
• VTYPCWSQRMZRRL-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[1-[2,4,6-tri(propan-2-yl)phenyl]sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC(C)C1=CC(C(C)C)=CC(C(C)C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCCC1 VTYPCWSQRMZRRL-UHFFFAOYSA-N 0.000 claims 1
• GHSJMMFSCQOTTM-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[1-[2-(trifluoromethyl)phenyl]sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2)C(F)(F)F)CC1 GHSJMMFSCQOTTM-UHFFFAOYSA-N 0.000 claims 1
• ACNNMIPFVRLAJD-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[1-[3-(trifluoromethyl)phenyl]sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(C=CC=2)C(F)(F)F)CC1 ACNNMIPFVRLAJD-UHFFFAOYSA-N 0.000 claims 1
• FGSVZPVOURWQIA-UHFFFAOYSA-N 1-[4-(1h-benzimidazol-2-ylmethyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3NC4=CC=CC=C4N=3)CC2)CCCC1 FGSVZPVOURWQIA-UHFFFAOYSA-N 0.000 claims 1
• HNNYOFDDVKPGMV-UHFFFAOYSA-N 1-[4-(2-ethoxyethyl)piperazin-1-yl]-2-[[2-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound C1CN(CCOCC)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC2=CC=CC=C2C1 HNNYOFDDVKPGMV-UHFFFAOYSA-N 0.000 claims 1
• RQMBWTPMONVHOB-UHFFFAOYSA-N 1-[4-(2-fluorophenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C(=CC=CC=2)F)CCC1 RQMBWTPMONVHOB-UHFFFAOYSA-N 0.000 claims 1
• OIDUQTUKNIHTBE-UHFFFAOYSA-N 1-[4-(2-methoxyethyl)piperazin-1-yl]-2-[[2-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound C1CN(CCOC)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC2=CC=CC=C2C1 OIDUQTUKNIHTBE-UHFFFAOYSA-N 0.000 claims 1
• UQHWBTWOWDTQMS-UHFFFAOYSA-N 1-[4-(2-phenylethyl)piperazin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCC=3C=CC=CC=3)CC2)CCC1 UQHWBTWOWDTQMS-UHFFFAOYSA-N 0.000 claims 1
• TXCLBUGFTAHQLQ-UHFFFAOYSA-N 1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCCC3)CC2)CCC1 TXCLBUGFTAHQLQ-UHFFFAOYSA-N 0.000 claims 1
• BMSOLTIKXAHCCC-UHFFFAOYSA-N 1-[4-(3,4-dichlorophenyl)piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 BMSOLTIKXAHCCC-UHFFFAOYSA-N 0.000 claims 1
• FWTRRWJQERQXEH-UHFFFAOYSA-N 1-[4-(3,4-dichlorophenyl)piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1N1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 FWTRRWJQERQXEH-UHFFFAOYSA-N 0.000 claims 1
• BNPXXFHHEDQSHT-UHFFFAOYSA-N 1-[4-(3,4-dichlorophenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(Cl)C(Cl)=CC=2)CCCC1 BNPXXFHHEDQSHT-UHFFFAOYSA-N 0.000 claims 1
• QFDCFOKUZKKIBE-UHFFFAOYSA-N 1-[4-(3,4-dichlorophenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(Cl)C(Cl)=CC=2)CCC1 QFDCFOKUZKKIBE-UHFFFAOYSA-N 0.000 claims 1
• HBZPOBFSXMHWNO-UHFFFAOYSA-N 1-[4-(3,4-dihydro-1h-2,6-naphthyridin-2-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CC3=CC=NC=C3CC2)CCCC1 HBZPOBFSXMHWNO-UHFFFAOYSA-N 0.000 claims 1
• RMQWTWVIRAWRBB-UHFFFAOYSA-N 1-[4-(3,4-dihydro-1h-pyrrolo[1,2-a]pyrazin-2-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CC3=CC=CN3CC2)CCCC1 RMQWTWVIRAWRBB-UHFFFAOYSA-N 0.000 claims 1
• MWOHDUGKKQFGAW-UHFFFAOYSA-N 1-[4-(3,4-dimethylphenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(C)C(C)=CC=2)CCCC1 MWOHDUGKKQFGAW-UHFFFAOYSA-N 0.000 claims 1
• QQWWFHMBACDFQC-UHFFFAOYSA-N 1-[4-(3,4-dimethylphenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(C)C(C)=CC=2)CCC1 QQWWFHMBACDFQC-UHFFFAOYSA-N 0.000 claims 1
• IJAZSBJFMWYZCD-UHFFFAOYSA-N 1-[4-(3,5-dimethoxyphenyl)piperazin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound COC1=CC(OC)=CC(N2CCN(CC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)=C1 IJAZSBJFMWYZCD-UHFFFAOYSA-N 0.000 claims 1
• TVHAHEBJVSDIDA-UHFFFAOYSA-N 1-[4-(3,5-dimethoxyphenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(OC)C=C(OC)C=2)CCCC1 TVHAHEBJVSDIDA-UHFFFAOYSA-N 0.000 claims 1
• UWVZRKJCJDZAHZ-UHFFFAOYSA-N 1-[4-(3,5-dimethoxyphenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(OC)C=C(OC)C=2)CCC1 UWVZRKJCJDZAHZ-UHFFFAOYSA-N 0.000 claims 1
• CXAMHOOYKNNGMR-UHFFFAOYSA-N 1-[4-(3-chlorophenyl)piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC=CC(N2CCN(CC2)C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=C1 CXAMHOOYKNNGMR-UHFFFAOYSA-N 0.000 claims 1
• CCLONGXIIMZRHJ-UHFFFAOYSA-N 1-[4-(3-chlorophenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(Cl)C=CC=2)CCCC1 CCLONGXIIMZRHJ-UHFFFAOYSA-N 0.000 claims 1
• CARNUSOCWBLXIO-UHFFFAOYSA-N 1-[4-(3-chlorophenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(Cl)C=CC=2)CCC1 CARNUSOCWBLXIO-UHFFFAOYSA-N 0.000 claims 1
• QHGDEBJCNQKKFV-UHFFFAOYSA-N 1-[4-(3-methoxyphenyl)piperazin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound COC1=CC=CC(N2CCN(CC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)=C1 QHGDEBJCNQKKFV-UHFFFAOYSA-N 0.000 claims 1
• HWQQEGAYPNCAQW-UHFFFAOYSA-N 1-[4-(4-benzyl-1,3-thiazol-2-yl)piperazin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2SC=C(CC=3C=CC=CC=3)N=2)CCCC1 HWQQEGAYPNCAQW-UHFFFAOYSA-N 0.000 claims 1
• QKYPZQVKYPRSKS-UHFFFAOYSA-N 1-[4-(4-fluorophenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CC(F)=CC=2)CCCC1 QKYPZQVKYPRSKS-UHFFFAOYSA-N 0.000 claims 1
• ORXFYXZWTNHPEB-UHFFFAOYSA-N 1-[4-(4-fluorophenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CC(F)=CC=2)CCC1 ORXFYXZWTNHPEB-UHFFFAOYSA-N 0.000 claims 1
• ZHFVCDXMPIXZAR-UHFFFAOYSA-N 1-[4-(4-fluoropiperidin-1-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCC(F)CC2)CCCC1 ZHFVCDXMPIXZAR-UHFFFAOYSA-N 0.000 claims 1
• NZRPPZMMHAPCNW-UHFFFAOYSA-N 1-[4-(4-methoxyphenyl)piperazin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1=CC(OC)=CC=C1N1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CC1 NZRPPZMMHAPCNW-UHFFFAOYSA-N 0.000 claims 1
• ASDZLKAONROZLQ-UHFFFAOYSA-N 1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCN1C1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CC1 ASDZLKAONROZLQ-UHFFFAOYSA-N 0.000 claims 1
• FGTMGQCWVZCCGN-UHFFFAOYSA-N 1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCN1C1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC1 FGTMGQCWVZCCGN-UHFFFAOYSA-N 0.000 claims 1
• KRZQWDAQYRBMFT-UHFFFAOYSA-N 1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-2-[[2-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound C1CN(C)CCN1C1CCN(C(=O)COCC2N(CC3=CC=CC=C3C2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC1 KRZQWDAQYRBMFT-UHFFFAOYSA-N 0.000 claims 1
• PQWDROLKDOSWOR-UHFFFAOYSA-N 1-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC=C(Cl)C=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 PQWDROLKDOSWOR-UHFFFAOYSA-N 0.000 claims 1
• MOAQJFOVDHUFEY-UHFFFAOYSA-N 1-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C(=CC=C(Cl)C=2)C)CCC1 MOAQJFOVDHUFEY-UHFFFAOYSA-N 0.000 claims 1
• DVAPHLLAGQDTGF-UHFFFAOYSA-N 1-[4-(6,8-dihydro-5h-[1,2,4]triazolo[1,5-a]pyrazin-7-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CC3=NC=NN3CC2)CCCC1 DVAPHLLAGQDTGF-UHFFFAOYSA-N 0.000 claims 1
• GUQZOXLIBKDAQP-UHFFFAOYSA-N 1-[4-(6,8-dihydro-5h-imidazo[1,2-a]pyrazin-7-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CC3=NC=CN3CC2)CCCC1 GUQZOXLIBKDAQP-UHFFFAOYSA-N 0.000 claims 1
• KGATXCDHEGAKTQ-UHFFFAOYSA-N 1-[4-(6-chloro-1,3-benzothiazol-2-yl)piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound S1C2=CC(Cl)=CC=C2N=C1N(CC1)CCN1C(=O)COCC1CCCCN1S(=O)(=O)C1=C(Cl)C=CC=C1Cl KGATXCDHEGAKTQ-UHFFFAOYSA-N 0.000 claims 1
• WZNDVCZYXZCQNO-UHFFFAOYSA-N 1-[4-(6-fluoro-3,4-dihydro-1h-isoquinolin-2-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CC3=CC=C(F)C=C3CC2)CCCC1 WZNDVCZYXZCQNO-UHFFFAOYSA-N 0.000 claims 1
• CKLBRXUCOFQEEN-UHFFFAOYSA-N 1-[4-(6-methyl-1h-benzimidazol-2-yl)piperidin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound N=1C2=CC(C)=CC=C2NC=1C(CC1)CCN1C(=O)COCC1CCCCN1S(=O)(=O)C1=C(C)C=C(C)C=C1C CKLBRXUCOFQEEN-UHFFFAOYSA-N 0.000 claims 1
• YDOHIUDFWJJGSD-UHFFFAOYSA-N 1-[4-(cyclohexylmethyl)piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC3CCCCC3)CC2)CCCC1 YDOHIUDFWJJGSD-UHFFFAOYSA-N 0.000 claims 1
• VILUFDZSNZPRCA-UHFFFAOYSA-N 1-[4-(cyclohexylmethyl)piperazin-1-yl]-2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC3CCCCC3)CC2)CCCC1 VILUFDZSNZPRCA-UHFFFAOYSA-N 0.000 claims 1
• SSMSQYZBYYSMMW-UHFFFAOYSA-N 1-[4-(cyclohexylmethyl)piperazin-1-yl]-2-[[1-(3,4-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC3CCCCC3)CC2)CCC1 SSMSQYZBYYSMMW-UHFFFAOYSA-N 0.000 claims 1
• GHAYWJMTOHSIHE-UHFFFAOYSA-N 1-[4-(cyclohexylmethyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC3CCCCC3)CC2)CCC1 GHAYWJMTOHSIHE-UHFFFAOYSA-N 0.000 claims 1
• CYGBZNANDPSJRB-UHFFFAOYSA-N 1-[4-[(1,5-dimethylpyrazol-4-yl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC3=C(N(C)N=C3)C)CC2)CCCC1 CYGBZNANDPSJRB-UHFFFAOYSA-N 0.000 claims 1
• XXQZCDXBZLCBBT-UHFFFAOYSA-N 1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCC1CN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC1 XXQZCDXBZLCBBT-UHFFFAOYSA-N 0.000 claims 1
• FOHHNKPUGCCKQR-UHFFFAOYSA-N 1-[4-[(2-fluorophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C(=CC=CC=3)F)CC2)CCCC1 FOHHNKPUGCCKQR-UHFFFAOYSA-N 0.000 claims 1
• CNGYKBBPOJAYBT-UHFFFAOYSA-N 1-[4-[(2-fluorophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C(=CC=CC=3)F)CC2)CCC1 CNGYKBBPOJAYBT-UHFFFAOYSA-N 0.000 claims 1
• AHNGQZVURKNFIL-UHFFFAOYSA-N 1-[4-[(3,4-dichlorophenyl)methyl]piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1CN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 AHNGQZVURKNFIL-UHFFFAOYSA-N 0.000 claims 1
• BNYKQXUKHTXKHP-UHFFFAOYSA-N 1-[4-[(3,4-dichlorophenyl)methyl]piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1CN1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 BNYKQXUKHTXKHP-UHFFFAOYSA-N 0.000 claims 1
• JALIVNRYQNNEIY-UHFFFAOYSA-N 1-[4-[(3,4-dichlorophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=C(Cl)C(Cl)=CC=3)CC2)CCCC1 JALIVNRYQNNEIY-UHFFFAOYSA-N 0.000 claims 1
• KPDQTWQKCPLDJO-UHFFFAOYSA-N 1-[4-[(3,4-dichlorophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=C(Cl)C(Cl)=CC=3)CC2)CCC1 KPDQTWQKCPLDJO-UHFFFAOYSA-N 0.000 claims 1
• CWYIPDPFVFWNDB-UHFFFAOYSA-N 1-[4-[(4-bromophenyl)methyl]piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(Br)=CC=3)CC2)CCCC1 CWYIPDPFVFWNDB-UHFFFAOYSA-N 0.000 claims 1
• MQEALGADWDWVDX-UHFFFAOYSA-N 1-[4-[(4-bromophenyl)methyl]piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(Br)=CC=3)CC2)CCC1 MQEALGADWDWVDX-UHFFFAOYSA-N 0.000 claims 1
• QRKGKZJPNNYYLE-UHFFFAOYSA-N 1-[4-[(4-bromophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(Br)=CC=3)CC2)CCCC1 QRKGKZJPNNYYLE-UHFFFAOYSA-N 0.000 claims 1
• PISIDUJDDAWECE-UHFFFAOYSA-N 1-[4-[(4-bromophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(Br)=CC=3)CC2)CCC1 PISIDUJDDAWECE-UHFFFAOYSA-N 0.000 claims 1
• RFWDSLPOIZRPTQ-UHFFFAOYSA-N 1-[4-[(4-chloro-2-phenyl-1h-imidazol-5-yl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC3=C(NC(=N3)C=3C=CC=CC=3)Cl)CC2)CCCC1 RFWDSLPOIZRPTQ-UHFFFAOYSA-N 0.000 claims 1
• OTSISIMQNGHKRJ-UHFFFAOYSA-N 1-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1=CC(Cl)=CC=C1CN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 OTSISIMQNGHKRJ-UHFFFAOYSA-N 0.000 claims 1
• FZFUBOJYAFVEPV-UHFFFAOYSA-N 1-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1=CC(Cl)=CC=C1CN1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 FZFUBOJYAFVEPV-UHFFFAOYSA-N 0.000 claims 1
• QSTGKAYPKISDIS-UHFFFAOYSA-N 1-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(Cl)=CC=3)CC2)CCCC1 QSTGKAYPKISDIS-UHFFFAOYSA-N 0.000 claims 1
• GXBZFTYQFYNJRP-UHFFFAOYSA-N 1-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(Cl)=CC=3)CC2)CCC1 GXBZFTYQFYNJRP-UHFFFAOYSA-N 0.000 claims 1
• ASTUSRKPFRBHLR-UHFFFAOYSA-N 1-[4-[2-(2,5-dimethylpyrrol-1-yl)ethyl]piperazin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC=C(C)N1CCN1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CC1 ASTUSRKPFRBHLR-UHFFFAOYSA-N 0.000 claims 1
• MFCJXOUCJHSLDD-UHFFFAOYSA-N 1-[4-[2-(2,5-dimethylpyrrol-1-yl)ethyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCN3C(=CC=C3C)C)CC2)CCCC1 MFCJXOUCJHSLDD-UHFFFAOYSA-N 0.000 claims 1
• FAOIOUYTOPUIMZ-UHFFFAOYSA-N 1-[4-[2-(2,5-dimethylpyrrol-1-yl)ethyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCN3C(=CC=C3C)C)CC2)CCC1 FAOIOUYTOPUIMZ-UHFFFAOYSA-N 0.000 claims 1
• VJUAGTKWXSLKMG-UHFFFAOYSA-N 1-[4-[2-(2,5-dimethylpyrrol-1-yl)ethyl]piperazin-1-yl]-2-[[1-(4-methoxyphenyl)sulfonyl-2,3-dihydroindol-2-yl]methoxy]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C2=CC=CC=C2CC1COCC(=O)N1CCN(CCN2C(=CC=C2C)C)CC1 VJUAGTKWXSLKMG-UHFFFAOYSA-N 0.000 claims 1
• AHVUZZHWIYEYGN-UHFFFAOYSA-N 1-[4-[2-[di(propan-2-yl)amino]ethyl]piperazin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(CCN(C(C)C)C(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CCCC1 AHVUZZHWIYEYGN-UHFFFAOYSA-N 0.000 claims 1
• JWSIEOHTOUYGGD-UHFFFAOYSA-N 1-[4-[2-[di(propan-2-yl)amino]ethyl]piperazin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1CN(CCN(C(C)C)C(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CCC1 JWSIEOHTOUYGGD-UHFFFAOYSA-N 0.000 claims 1
• QIGKDVXGXQYLJE-UHFFFAOYSA-N 1-[4-[2-[di(propan-2-yl)amino]ethyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCN(C(C)C)C(C)C)CC2)CCCC1 QIGKDVXGXQYLJE-UHFFFAOYSA-N 0.000 claims 1
• MNBSLSJORSJMEK-UHFFFAOYSA-N 1-[4-[2-[di(propan-2-yl)amino]ethyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCN(C(C)C)C(C)C)CC2)CCC1 MNBSLSJORSJMEK-UHFFFAOYSA-N 0.000 claims 1
• HTDBTGSRBLBJLI-UHFFFAOYSA-N 1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]-2-[[1-[3-(trifluoromethyl)phenyl]sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(CCCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C=C(C=CC=2)C(F)(F)F)CCCC1 HTDBTGSRBLBJLI-UHFFFAOYSA-N 0.000 claims 1
• IOURMDWSMIBLAY-UHFFFAOYSA-N 1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]-2-[[2-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound C1CN(CCCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC2=CC=CC=C2C1 IOURMDWSMIBLAY-UHFFFAOYSA-N 0.000 claims 1
• XMCFLLJPDLYIEU-UHFFFAOYSA-N 1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]-2-[[2-(4-methoxy-2,3,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound CC1=C(C)C(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCCN(C)C)CC2)CC2=CC=CC=C2C1 XMCFLLJPDLYIEU-UHFFFAOYSA-N 0.000 claims 1
• HLZXEYCBHJHXPK-UHFFFAOYSA-N 1-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(C(F)(F)F)=CN=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 HLZXEYCBHJHXPK-UHFFFAOYSA-N 0.000 claims 1
• AOZOFDZMXHRZTJ-UHFFFAOYSA-N 1-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C(=CC(=CN=2)C(F)(F)F)Cl)CCCC1 AOZOFDZMXHRZTJ-UHFFFAOYSA-N 0.000 claims 1
• JQPBEYYDKBPGQW-UHFFFAOYSA-N 1-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C(=CC(=CN=2)C(F)(F)F)Cl)CCC1 JQPBEYYDKBPGQW-UHFFFAOYSA-N 0.000 claims 1
• PMJFHPJDXODGKN-UHFFFAOYSA-N 1-[4-[[2-(4-fluoro-n-methylanilino)pyrimidin-5-yl]methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=NC(=NC=3)N(C)C=3C=CC(F)=CC=3)CC2)CCCC1 PMJFHPJDXODGKN-UHFFFAOYSA-N 0.000 claims 1
• FPIRBHDGWMWJEP-UHFFFAOYSA-N 1-hydroxy-7-azabenzotriazole Chemical compound C1=CN=C2N(O)N=NC2=C1 FPIRBHDGWMWJEP-UHFFFAOYSA-N 0.000 claims 1
• OACUQXUBWLSNCA-UHFFFAOYSA-N 2-[(1-isoquinolin-5-ylsulfonylpiperidin-2-yl)methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=NC=C3C=CC=2)CC1 OACUQXUBWLSNCA-UHFFFAOYSA-N 0.000 claims 1
• PXIVXNFODWNGIJ-UHFFFAOYSA-N 2-[(1-naphthalen-1-ylsulfonylpiperidin-2-yl)methoxy]-1-(4-pyrrolidin-1-ylpiperidin-1-yl)ethanone Chemical compound C1CCCN(S(=O)(=O)C=2C3=CC=CC=C3C=CC=2)C1COCC(=O)N(CC1)CCC1N1CCCC1 PXIVXNFODWNGIJ-UHFFFAOYSA-N 0.000 claims 1
• ZULBQDJWDOCBTH-UHFFFAOYSA-N 2-[2-[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]ethoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(CCOCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCCC1 ZULBQDJWDOCBTH-UHFFFAOYSA-N 0.000 claims 1
• HYJVAKPUVOTFJS-UHFFFAOYSA-N 2-[2-[1-(4-methoxyphenyl)sulfonylpiperidin-2-yl]ethoxy]-1-[4-(2-phenylethyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C(CCOCC(=O)N2CCN(CCC=3C=CC=CC=3)CC2)CCCC1 HYJVAKPUVOTFJS-UHFFFAOYSA-N 0.000 claims 1
• HIJWMGDWFFFPRM-UHFFFAOYSA-N 2-[2-[1-(4-methoxyphenyl)sulfonylpiperidin-2-yl]ethoxy]-1-[4-(2-piperidin-1-ylethyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C(CCOCC(=O)N2CCN(CCN3CCCCC3)CC2)CCCC1 HIJWMGDWFFFPRM-UHFFFAOYSA-N 0.000 claims 1
• LUAVBURLSJTNNK-UHFFFAOYSA-N 2-[2-[1-(4-methoxyphenyl)sulfonylpiperidin-2-yl]ethoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C(CCOCC(=O)N2CCC(CCN3CCCCC3)CC2)CCCC1 LUAVBURLSJTNNK-UHFFFAOYSA-N 0.000 claims 1
• SNDNJDXVHDHFSQ-UHFFFAOYSA-N 2-[4-[2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetyl]piperazin-1-yl]pyridine-3-carbonitrile Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C(=CC=CN=2)C#N)CCCC1 SNDNJDXVHDHFSQ-UHFFFAOYSA-N 0.000 claims 1
• QCPCAGLXHDUXCA-UHFFFAOYSA-N 2-[4-[2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]acetyl]-1,4-diazepan-1-yl]pyridine-3-carbonitrile Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCC2)C=2C(=CC=CN=2)C#N)CCC1 QCPCAGLXHDUXCA-UHFFFAOYSA-N 0.000 claims 1
• IFVGRTTZJWKEPY-UHFFFAOYSA-N 2-[4-[2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]acetyl]piperazin-1-yl]pyridine-3-carbonitrile Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C(=CC=CN=2)C#N)CCC1 IFVGRTTZJWKEPY-UHFFFAOYSA-N 0.000 claims 1
• BWQFHVQHCZBNHA-GHVWMZMZSA-N 2-[[(2r)-1-(2-chloro-6-methylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COC[C@@H]2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2C)Cl)CC1 BWQFHVQHCZBNHA-GHVWMZMZSA-N 0.000 claims 1
• KSVJCVQLQYOACA-PPLJNSMQSA-N 2-[[(2r)-1-(4-methoxy-2,3,6-trimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.CC1=C(C)C(OC)=CC(C)=C1S(=O)(=O)N1[C@@H](COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCC1 KSVJCVQLQYOACA-PPLJNSMQSA-N 0.000 claims 1
• BWQFHVQHCZBNHA-FGJQBABTSA-N 2-[[(2s)-1-(2-chloro-6-methylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COC[C@H]2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2C)Cl)CC1 BWQFHVQHCZBNHA-FGJQBABTSA-N 0.000 claims 1
• PSZQVVVOIIPHQE-FTBISJDPSA-N 2-[[(2s)-1-(2-chloro-6-methylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone;hydrochloride Chemical compound Cl.CC1=CC=CC(Cl)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCC(CCN3CCCC3)CC2)CCC1 PSZQVVVOIIPHQE-FTBISJDPSA-N 0.000 claims 1
• CAWSROYGZOKUNC-IKXQUJFKSA-N 2-[[(2s)-1-(2-chloro-6-methylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1CN1CCN(C(=O)COC[C@H]2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2C)Cl)CC1 CAWSROYGZOKUNC-IKXQUJFKSA-N 0.000 claims 1
• LTPFFIWXMIAQEI-FTBISJDPSA-N 2-[[(2s)-1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-4-yloxypiperidin-1-yl)ethanone;hydrochloride Chemical compound Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCC(CC2)OC=2C=CN=CC=2)CCCC1 LTPFFIWXMIAQEI-FTBISJDPSA-N 0.000 claims 1
• PWVUJTOPRDSRMG-JIDHJSLPSA-N 2-[[(2s)-1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone;hydrochloride Chemical compound Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCC(CCN3CCCC3)CC2)CCC1 PWVUJTOPRDSRMG-JIDHJSLPSA-N 0.000 claims 1
• FUDFZLURKHNCDS-DEOSSOPVSA-N 2-[[(2s)-1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCN(CC3CCN(C)CC3)CC2)CCC1 FUDFZLURKHNCDS-DEOSSOPVSA-N 0.000 claims 1
• KYYZWHKZTRSNRK-VWLOTQADSA-N 2-[[(3s)-2-(2,4-dichlorophenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COC[C@H]2N(CC3=CC=CC=C3C2)S(=O)(=O)C=2C(=CC(Cl)=CC=2)Cl)CC1 KYYZWHKZTRSNRK-VWLOTQADSA-N 0.000 claims 1
• VMJFPEVVOFWGNY-LJAQVGFWSA-N 2-[[(3s)-2-(4-methoxy-2,6-dimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCC(CCN3CCCC3)CC2)CC2=CC=CC=C2C1 VMJFPEVVOFWGNY-LJAQVGFWSA-N 0.000 claims 1
• CJVGQWCRKVMNMD-LJAQVGFWSA-N 2-[[(3s)-2-(4-methoxy-2,6-dimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCN(CC3CCN(C)CC3)CC2)CC2=CC=CC=C2C1 CJVGQWCRKVMNMD-LJAQVGFWSA-N 0.000 claims 1
• UCIPJYNUZCZOTQ-SANMLTNESA-N 2-[[(3s)-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CC2=CC=CC=C2C1 UCIPJYNUZCZOTQ-SANMLTNESA-N 0.000 claims 1
• UYVWHJGJBRYSTN-MHZLTWQESA-N 2-[[(3s)-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCC(CCN3CCCC3)CC2)CC2=CC=CC=C2C1 UYVWHJGJBRYSTN-MHZLTWQESA-N 0.000 claims 1
• GLPGOQRYDGWWAZ-LPCSYZHESA-N 2-[[(3s)-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1=CC(OC)=CC=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCN(CC3CCN(C)CC3)CC2)CC2=CC=CC=C2C1 GLPGOQRYDGWWAZ-LPCSYZHESA-N 0.000 claims 1
• OCQQZRXTIMFUNJ-UHFFFAOYSA-N 2-[[1-(1-benzothiophen-2-ylsulfonyl)piperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2SC3=CC=CC=C3C=2)CC1 OCQQZRXTIMFUNJ-UHFFFAOYSA-N 0.000 claims 1
• KUNOECHYRSAZOR-UHFFFAOYSA-N 2-[[1-(1-benzothiophen-3-ylsulfonyl)piperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=CC=C3SC=2)CC1 KUNOECHYRSAZOR-UHFFFAOYSA-N 0.000 claims 1
• SLPCXDZOIZWXTJ-UHFFFAOYSA-N 2-[[1-(1-benzothiophen-3-ylsulfonyl)piperidin-2-yl]methoxy]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethanone Chemical compound C1CN(C)CCN1C1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=CC=C3SC=2)CC1 SLPCXDZOIZWXTJ-UHFFFAOYSA-N 0.000 claims 1
• FNKPVVYCVDCGEU-UHFFFAOYSA-N 2-[[1-(1-benzothiophen-3-ylsulfonyl)piperidin-2-yl]methoxy]-1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1CN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=CC=C3SC=2)CC1 FNKPVVYCVDCGEU-UHFFFAOYSA-N 0.000 claims 1
• UEPPUVUZZILNMX-UHFFFAOYSA-N 2-[[1-(2,3-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=C(Cl)C=CC=2)Cl)CC1 UEPPUVUZZILNMX-UHFFFAOYSA-N 0.000 claims 1
• GSCOJOOTAKPQOG-UHFFFAOYSA-N 2-[[1-(2,5-dichlorothiophen-3-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C2=C(SC(Cl)=C2)Cl)CC1 GSCOJOOTAKPQOG-UHFFFAOYSA-N 0.000 claims 1
• YTNDCRYTJVKJDU-UHFFFAOYSA-N 2-[[1-(2,5-dimethylthiophen-3-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C2=C(SC(C)=C2)C)CC1 YTNDCRYTJVKJDU-UHFFFAOYSA-N 0.000 claims 1
• LVGAVVPJUDXUEA-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(2-pyridin-3-ylpyrrolidin-1-yl)ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)C=2C=NC=CC=2)CCCC1 LVGAVVPJUDXUEA-UHFFFAOYSA-N 0.000 claims 1
• CKGCRLMJEJYQPA-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(3-pyridin-4-ylpyrrolidin-1-yl)ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2C=CN=CC=2)CCCC1 CKGCRLMJEJYQPA-UHFFFAOYSA-N 0.000 claims 1
• ZHYJSGFEPXEITC-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-methyl-1,4-diazepan-1-yl)ethanone Chemical compound C1CN(C)CCCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCCC1 ZHYJSGFEPXEITC-UHFFFAOYSA-N 0.000 claims 1
• GMTFPXMRYMTELC-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-piperidin-1-ylpiperidin-1-yl)ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCCC2)CCCC1 GMTFPXMRYMTELC-UHFFFAOYSA-N 0.000 claims 1
• PKCHCYXPVJYLQN-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2N=CC=CC=2)CCCC1 PKCHCYXPVJYLQN-UHFFFAOYSA-N 0.000 claims 1
• KXGMBNVYRZIXLM-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-4-ylpiperazin-1-yl)ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CN=CC=2)CCCC1 KXGMBNVYRZIXLM-UHFFFAOYSA-N 0.000 claims 1
• YEYXKMIHQVKBKF-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyrrolidin-1-ylpiperidin-1-yl)ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCC2)CCCC1 YEYXKMIHQVKBKF-UHFFFAOYSA-N 0.000 claims 1
• MQYPOFBEOOYHEU-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-(pyridin-2-ylmethyl)pyrrolidin-1-yl]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)CC=2N=CC=CC=2)CCCC1 MQYPOFBEOOYHEU-UHFFFAOYSA-N 0.000 claims 1
• OACYPNOMTJCOIL-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-[(4,6-dimethylpyridin-2-yl)methyl]pyrrolidin-1-yl]ethanone Chemical compound CC1=CC(C)=NC(CC2N(CCC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=C1 OACYPNOMTJCOIL-UHFFFAOYSA-N 0.000 claims 1
• PGKOEGAHHJIBMA-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-[(6-methylpyridin-2-yl)methyl]piperidin-1-yl]ethanone Chemical compound CC1=CC=CC(CC2N(CCCC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=N1 PGKOEGAHHJIBMA-UHFFFAOYSA-N 0.000 claims 1
• BWVGRRKUOXQLRI-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-[(6-methylpyridin-2-yl)methyl]pyrrolidin-1-yl]ethanone Chemical compound CC1=CC=CC(CC2N(CCC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=N1 BWVGRRKUOXQLRI-UHFFFAOYSA-N 0.000 claims 1
• LAOQNIXJKBRRGO-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-[4-(dimethylamino)phenyl]pyrrolidin-1-yl]ethanone Chemical compound C1=CC(N(C)C)=CC=C1C1N(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCC1 LAOQNIXJKBRRGO-UHFFFAOYSA-N 0.000 claims 1
• MHWNLPQLUCVWJJ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 MHWNLPQLUCVWJJ-UHFFFAOYSA-N 0.000 claims 1
• ISKIIZUVOZWDIQ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 ISKIIZUVOZWDIQ-UHFFFAOYSA-N 0.000 claims 1
• VLAPRQCGIKLFQJ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone Chemical compound FC1=CC=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 VLAPRQCGIKLFQJ-UHFFFAOYSA-N 0.000 claims 1
• XLMQPRGESAWMBS-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-hydroxyethyl)piperazin-1-yl]ethanone Chemical compound C1CN(CCO)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCCC1 XLMQPRGESAWMBS-UHFFFAOYSA-N 0.000 claims 1
• GARFXKYWXCWEKO-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound COC1=CC=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 GARFXKYWXCWEKO-UHFFFAOYSA-N 0.000 claims 1
• CCJNUCXLJWMZNL-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCCC3)CC2)CCCC1 CCJNUCXLJWMZNL-UHFFFAOYSA-N 0.000 claims 1
• ZORXFAZPCVKVHB-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(3,4-dimethylphenyl)piperazin-1-yl]ethanone Chemical compound C1=C(C)C(C)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 ZORXFAZPCVKVHB-UHFFFAOYSA-N 0.000 claims 1
• ZWIFDPRVGYPPRI-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(3,5-dichloropyridin-2-yl)piperazin-1-yl]ethanone Chemical compound ClC1=CC(Cl)=CN=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 ZWIFDPRVGYPPRI-UHFFFAOYSA-N 0.000 claims 1
• UGLLUFKYOJRVQX-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(3-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound COC1=CC=CC(N2CCN(CC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=C1 UGLLUFKYOJRVQX-UHFFFAOYSA-N 0.000 claims 1
• UJEQKKHGFIQGBC-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(F)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 UJEQKKHGFIQGBC-UHFFFAOYSA-N 0.000 claims 1
• BAHYFOTXVDQCEL-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 BAHYFOTXVDQCEL-UHFFFAOYSA-N 0.000 claims 1
• KVCMTEVQLGMJEK-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethanone Chemical compound C1CN(C)CCN1C1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 KVCMTEVQLGMJEK-UHFFFAOYSA-N 0.000 claims 1
• XFLMBMJDGOISPS-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[(2-fluorophenyl)methyl]piperazin-1-yl]ethanone Chemical compound FC1=CC=CC=C1CN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 XFLMBMJDGOISPS-UHFFFAOYSA-N 0.000 claims 1
• VFHVQHSQJKDTJA-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[(4-methylphenyl)methyl]piperazin-1-yl]ethanone Chemical compound C1=CC(C)=CC=C1CN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 VFHVQHSQJKDTJA-UHFFFAOYSA-N 0.000 claims 1
• USIISHYGQBRBKE-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[2-(2,5-dimethylpyrrol-1-yl)ethyl]piperazin-1-yl]ethanone Chemical compound CC1=CC=C(C)N1CCN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 USIISHYGQBRBKE-UHFFFAOYSA-N 0.000 claims 1
• BCBFSBZZSNGJNF-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[2-[di(propan-2-yl)amino]ethyl]piperazin-1-yl]ethanone Chemical compound C1CN(CCN(C(C)C)C(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCCC1 BCBFSBZZSNGJNF-UHFFFAOYSA-N 0.000 claims 1
• DDERZQUZWVBXKO-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]ethanone Chemical compound C1CN(CCCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCCC1 DDERZQUZWVBXKO-UHFFFAOYSA-N 0.000 claims 1
• BMTJQPUPRRSMLF-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethanone Chemical compound FC(F)(F)C1=CC=CC(N2CCN(CC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=C1 BMTJQPUPRRSMLF-UHFFFAOYSA-N 0.000 claims 1
• XPZHGECYUIYGPC-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]ethanone Chemical compound N1=CC(C(F)(F)F)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 XPZHGECYUIYGPC-UHFFFAOYSA-N 0.000 claims 1
• MNZKPJYBASWHKI-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-n-[[4-(dimethylamino)phenyl]methyl]-n-propan-2-ylacetamide Chemical compound C1CCCN(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)C1COCC(=O)N(C(C)C)CC1=CC=C(N(C)C)C=C1 MNZKPJYBASWHKI-UHFFFAOYSA-N 0.000 claims 1
• HMIRULGUTAEAIY-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-piperidin-1-ylpiperidin-1-yl)ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCCC2)CCC1 HMIRULGUTAEAIY-UHFFFAOYSA-N 0.000 claims 1
• YWXMQMWQAZOTPW-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[2-(pyridin-4-ylmethyl)piperidin-1-yl]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCCC2)CC=2C=CN=CC=2)CCC1 YWXMQMWQAZOTPW-UHFFFAOYSA-N 0.000 claims 1
• LHGKPFKYTIKKFZ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 LHGKPFKYTIKKFZ-UHFFFAOYSA-N 0.000 claims 1
• PWNCORRJYFEMJP-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(2-phenylethyl)piperazin-1-yl]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCC=3C=CC=CC=3)CC2)CCC1 PWNCORRJYFEMJP-UHFFFAOYSA-N 0.000 claims 1
• DBORZRAKMDGUPJ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCCC3)CC2)CCC1 DBORZRAKMDGUPJ-UHFFFAOYSA-N 0.000 claims 1
• JVSVMDFBQALZMW-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(3,4-dimethylphenyl)piperazin-1-yl]ethanone Chemical compound C1=C(C)C(C)=CC=C1N1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 JVSVMDFBQALZMW-UHFFFAOYSA-N 0.000 claims 1
• DDGFUZJAWNZEMQ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(3-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound COC1=CC=CC(N2CCN(CC2)C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=C1 DDGFUZJAWNZEMQ-UHFFFAOYSA-N 0.000 claims 1
• ZJKDJGFRJYETKI-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1N1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 ZJKDJGFRJYETKI-UHFFFAOYSA-N 0.000 claims 1
• LTKRKWDRHQYZMD-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethanone Chemical compound C1CN(C)CCN1C1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 LTKRKWDRHQYZMD-UHFFFAOYSA-N 0.000 claims 1
• JDRCUGRXNAMVEJ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[(4-methoxyphenyl)methyl]piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1CN1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 JDRCUGRXNAMVEJ-UHFFFAOYSA-N 0.000 claims 1
• BDMIDZCLVDBCBX-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[2-(2,5-dimethylpyrrol-1-yl)ethyl]piperazin-1-yl]ethanone Chemical compound CC1=CC=C(C)N1CCN1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 BDMIDZCLVDBCBX-UHFFFAOYSA-N 0.000 claims 1
• QMJBANSRJAVMQV-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]ethanone Chemical compound C1CN(CCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCC1 QMJBANSRJAVMQV-UHFFFAOYSA-N 0.000 claims 1
• RLCQKMHDOMCUMR-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]ethanone Chemical compound C1CN(CCCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCC1 RLCQKMHDOMCUMR-UHFFFAOYSA-N 0.000 claims 1
• POGIAEQSZUKXRJ-UHFFFAOYSA-N 2-[[1-(2-chloro-6-methylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2C)Cl)CC1 POGIAEQSZUKXRJ-UHFFFAOYSA-N 0.000 claims 1
• WLQQDMJBDHXXKA-UHFFFAOYSA-N 2-[[1-(2-chloronaphthalen-1-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=CC=C3C=CC=2Cl)CC1 WLQQDMJBDHXXKA-UHFFFAOYSA-N 0.000 claims 1
• XVCLMSJGFRXVAQ-UHFFFAOYSA-N 2-[[1-(2-chlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2)Cl)CC1 XVCLMSJGFRXVAQ-UHFFFAOYSA-N 0.000 claims 1
• RAFNGJGFAUCMJK-UHFFFAOYSA-N 2-[[1-(2-methylnaphthalen-1-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=CC=C3C=CC=2C)CC1 RAFNGJGFAUCMJK-UHFFFAOYSA-N 0.000 claims 1
• AUPQRROPFURMHZ-UHFFFAOYSA-N 2-[[1-(2-methylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2)C)CC1 AUPQRROPFURMHZ-UHFFFAOYSA-N 0.000 claims 1
• MUYSWUOSVMZKDP-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonyl-2,3-dihydroindol-2-yl]methoxy]-n-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]acetamide Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C2=CC=CC=C2CC1COCC(=O)NCC(C=C1)=CC=C1CN1CCCC1 MUYSWUOSVMZKDP-UHFFFAOYSA-N 0.000 claims 1
• HEIOHUOYPPRFMI-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-phenylpiperazin-1-yl)ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CC=CC=2)CCCC1 HEIOHUOYPPRFMI-UHFFFAOYSA-N 0.000 claims 1
• UFSZGVCKUMOUAT-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyrrolidin-1-ylpiperidin-1-yl)ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCC2)CCCC1 UFSZGVCKUMOUAT-UHFFFAOYSA-N 0.000 claims 1
• DMSXORBRUMEPND-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-(piperidin-1-ylmethyl)morpholin-4-yl]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CC(CN3CCCCC3)OCC2)CCCC1 DMSXORBRUMEPND-UHFFFAOYSA-N 0.000 claims 1
• PKJWWLBEKVAPKL-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 PKJWWLBEKVAPKL-UHFFFAOYSA-N 0.000 claims 1
• NXCXCMATZDALAR-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone Chemical compound FC1=CC=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 NXCXCMATZDALAR-UHFFFAOYSA-N 0.000 claims 1
• ILBBMTNOWMCBTH-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-methoxyethyl)piperazin-1-yl]ethanone Chemical compound C1CN(CCOC)CCN1C(=O)COCC1N(S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)CCCC1 ILBBMTNOWMCBTH-UHFFFAOYSA-N 0.000 claims 1
• URZWFYPYXWPEMZ-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperazin-1-yl]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCN3CCCCC3)CC2)CCCC1 URZWFYPYXWPEMZ-UHFFFAOYSA-N 0.000 claims 1
• NTVYCZCMTHSLFV-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCCC3)CC2)CCCC1 NTVYCZCMTHSLFV-UHFFFAOYSA-N 0.000 claims 1
• DUUKGBRBIHLAPX-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(3-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound COC1=CC=CC(N2CCN(CC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)=C1 DUUKGBRBIHLAPX-UHFFFAOYSA-N 0.000 claims 1
• XJFFODIQDCOASF-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(F)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 XJFFODIQDCOASF-UHFFFAOYSA-N 0.000 claims 1
• GNVPZKORYHYGDK-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 GNVPZKORYHYGDK-UHFFFAOYSA-N 0.000 claims 1
• QHUHTTIJVAOQAR-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethanone Chemical compound C1CN(C)CCN1C1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 QHUHTTIJVAOQAR-UHFFFAOYSA-N 0.000 claims 1
• AFKSSRWBNOYWPG-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]ethanone Chemical compound C1CN(CCCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)CCCC1 AFKSSRWBNOYWPG-UHFFFAOYSA-N 0.000 claims 1
• XXDIJNZIGPCEHM-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-phenylpiperazin-1-yl)ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CC=CC=2)CCC1 XXDIJNZIGPCEHM-UHFFFAOYSA-N 0.000 claims 1
• UOWYLXDUOGRUFT-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 UOWYLXDUOGRUFT-UHFFFAOYSA-N 0.000 claims 1
• NZRWZLHRCXRLKJ-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperazin-1-yl]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCN3CCCCC3)CC2)CCC1 NZRWZLHRCXRLKJ-UHFFFAOYSA-N 0.000 claims 1
• RTQMUXXDEKODJQ-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCCC3)CC2)CCC1 RTQMUXXDEKODJQ-UHFFFAOYSA-N 0.000 claims 1
• GXVIHLVTFQKUCQ-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]ethanone Chemical compound C1CN(CCCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)CCC1 GXVIHLVTFQKUCQ-UHFFFAOYSA-N 0.000 claims 1
• UDYLPETXTYRNCF-UHFFFAOYSA-N 2-[[1-(3-bromophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-4-ylpiperazin-1-yl)ethanone Chemical compound BrC1=CC=CC(S(=O)(=O)N2C(CCCC2)COCC(=O)N2CCN(CC2)C=2C=CN=CC=2)=C1 UDYLPETXTYRNCF-UHFFFAOYSA-N 0.000 claims 1
• RZXLFXSAIYIFBO-UHFFFAOYSA-N 2-[[1-(3-bromophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(Br)C=CC=2)CC1 RZXLFXSAIYIFBO-UHFFFAOYSA-N 0.000 claims 1
• PPVAODBCWPENLS-UHFFFAOYSA-N 2-[[1-(3-bromophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound BrC1=CC=CC(S(=O)(=O)N2C(CCCC2)COCC(=O)N2CCC(CCN3CCCC3)CC2)=C1 PPVAODBCWPENLS-UHFFFAOYSA-N 0.000 claims 1
• FDLIAFFQTFXWLD-UHFFFAOYSA-N 2-[[1-(4-bromo-2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(Br)=CC=2Cl)Cl)CC1 FDLIAFFQTFXWLD-UHFFFAOYSA-N 0.000 claims 1
• NDBFGWQIDYZNDG-UHFFFAOYSA-N 2-[[1-(4-bromo-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-4-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(Br)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CN=CC=2)CCCC1 NDBFGWQIDYZNDG-UHFFFAOYSA-N 0.000 claims 1
• YBTHOGNTRBLSMU-UHFFFAOYSA-N 2-[[1-(4-bromo-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(Br)=CC=2C)C)CC1 YBTHOGNTRBLSMU-UHFFFAOYSA-N 0.000 claims 1
• KFWPECDKNVGUNC-UHFFFAOYSA-N 2-[[1-(4-bromo-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(Br)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCC3)CC2)CCCC1 KFWPECDKNVGUNC-UHFFFAOYSA-N 0.000 claims 1
• NDGSUKNCWJHFNS-UHFFFAOYSA-N 2-[[1-(4-bromophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-4-ylpiperazin-1-yl)ethanone Chemical compound C1=CC(Br)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CN=CC=2)CCCC1 NDGSUKNCWJHFNS-UHFFFAOYSA-N 0.000 claims 1
• AKOGHCIHZXOWEB-UHFFFAOYSA-N 2-[[1-(4-bromophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=CC(Br)=CC=2)CC1 AKOGHCIHZXOWEB-UHFFFAOYSA-N 0.000 claims 1
• OWGJBVYCBNBQLF-UHFFFAOYSA-N 2-[[1-(4-bromophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound C1=CC(Br)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCC3)CC2)CCCC1 OWGJBVYCBNBQLF-UHFFFAOYSA-N 0.000 claims 1
• ZBOKZWGMRHPJMX-UHFFFAOYSA-N 2-[[1-(4-chloro-2,5-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(Cl)=C(C)C=2)C)CC1 ZBOKZWGMRHPJMX-UHFFFAOYSA-N 0.000 claims 1
• KWSQMJUOHLAGPT-UHFFFAOYSA-N 2-[[1-(4-fluoro-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(F)=CC=2C)C)CC1 KWSQMJUOHLAGPT-UHFFFAOYSA-N 0.000 claims 1
• UDEIQBPOHFPVPQ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonyl-3,4-dihydro-2h-quinolin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C2=CC=CC=C2CCC1COCC(=O)N1CCN(C2CCN(C)CC2)CC1 UDEIQBPOHFPVPQ-UHFFFAOYSA-N 0.000 claims 1
• SIXPUEWATAUFSY-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(2-pyridin-2-ylpyrrolidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)C=2N=CC=CC=2)CCCC1 SIXPUEWATAUFSY-UHFFFAOYSA-N 0.000 claims 1
• LGKQILBLPCLPQJ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(3-pyridin-2-ylpyrrolidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2N=CC=CC=2)CCCC1 LGKQILBLPCLPQJ-UHFFFAOYSA-N 0.000 claims 1
• QOPJEJDHHHBTQJ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(3-pyridin-3-ylpyrrolidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2C=NC=CC=2)CCCC1 QOPJEJDHHHBTQJ-UHFFFAOYSA-N 0.000 claims 1
• XAPOWQDTWLGEFQ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(3-pyridin-4-ylpyrrolidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2C=CN=CC=2)CCCC1 XAPOWQDTWLGEFQ-UHFFFAOYSA-N 0.000 claims 1
• XIFFKZLEMPJMIO-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-methyl-1,4-diazepan-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(C)CCC2)CCCC1 XIFFKZLEMPJMIO-UHFFFAOYSA-N 0.000 claims 1
• NPXLKXQFFZWOOU-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-methyl-2-phenylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CN(C)CC2)C=2C=CC=CC=2)CCCC1 NPXLKXQFFZWOOU-UHFFFAOYSA-N 0.000 claims 1
• XVRZWBSVBVXZQT-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-methylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(C)CC2)CCCC1 XVRZWBSVBVXZQT-UHFFFAOYSA-N 0.000 claims 1
• LICUTKCPCUDLAZ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-propan-2-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C(C)C)CCCC1 LICUTKCPCUDLAZ-UHFFFAOYSA-N 0.000 claims 1
• KSCYVKROTITUFA-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2N=CC=CC=2)CCCC1 KSCYVKROTITUFA-UHFFFAOYSA-N 0.000 claims 1
• WZXZBHFTMOYBNX-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-3-yloxypiperidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)OC=2C=NC=CC=2)CCCC1 WZXZBHFTMOYBNX-UHFFFAOYSA-N 0.000 claims 1
• VESRQTXLMFEYIP-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-3-ylpiperidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)C=2C=NC=CC=2)CCCC1 VESRQTXLMFEYIP-UHFFFAOYSA-N 0.000 claims 1
• GZKIGMYXVNTBBM-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-4-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CN=CC=2)CCCC1 GZKIGMYXVNTBBM-UHFFFAOYSA-N 0.000 claims 1
• XPHONIPGKDSMHB-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-thieno[3,2-d]pyrimidin-4-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=3SC=CC=3N=CN=2)CCCC1 XPHONIPGKDSMHB-UHFFFAOYSA-N 0.000 claims 1
• PIKDMGHZKYOAFK-NQCNTLBGSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[(2s)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2[C@@H](CCC2)CN2CCCC2)CCCC1 PIKDMGHZKYOAFK-NQCNTLBGSA-N 0.000 claims 1
• RLAMHAIURGTGCD-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-(2-morpholin-4-ylethyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCCC2)CCN2CCOCC2)CCCC1 RLAMHAIURGTGCD-UHFFFAOYSA-N 0.000 claims 1
• OWVFXMCGQMQWIR-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-(piperidin-1-ylmethyl)pyrrolidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)CN2CCCCC2)CCCC1 OWVFXMCGQMQWIR-UHFFFAOYSA-N 0.000 claims 1
• WTPDHSVNURPTNC-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[3-(pyridin-3-ylmethyl)pyrrolidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC=3C=NC=CC=3)CC2)CCCC1 WTPDHSVNURPTNC-UHFFFAOYSA-N 0.000 claims 1
• LLRDYAYGXUHNPL-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCCC1 LLRDYAYGXUHNPL-UHFFFAOYSA-N 0.000 claims 1
• UMITVAXORSDTRI-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCCC1 UMITVAXORSDTRI-UHFFFAOYSA-N 0.000 claims 1
• UWCSEGWAHSGKHB-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-phenylethyl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCC=3C=CC=CC=3)CC2)CCCC1 UWCSEGWAHSGKHB-UHFFFAOYSA-N 0.000 claims 1
• RFTPUXZEALPYFT-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCCC3)CC2)CCCC1 RFTPUXZEALPYFT-UHFFFAOYSA-N 0.000 claims 1
• MUQNUVONPPPVSI-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone;hydrochloride Chemical compound Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCC3)CC2)CCCC1 MUQNUVONPPPVSI-UHFFFAOYSA-N 0.000 claims 1
• RZJHLXIJXQALCY-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(3-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound COC1=CC=CC(N2CCN(CC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)=C1 RZJHLXIJXQALCY-UHFFFAOYSA-N 0.000 claims 1
• ZCEPOFUXFOFFTP-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)CC1 ZCEPOFUXFOFFTP-UHFFFAOYSA-N 0.000 claims 1
• AEOVOMDMQMWOMG-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methylcyclohexyl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCC(C)CC2)CCCC1 AEOVOMDMQMWOMG-UHFFFAOYSA-N 0.000 claims 1
• LFYFOBQBVZSOCA-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCN(C)CC2)CCCC1 LFYFOBQBVZSOCA-UHFFFAOYSA-N 0.000 claims 1
• IYLBAWXSOJYSGE-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethanone;hydrochloride Chemical compound Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCN(C)CC2)CCCC1 IYLBAWXSOJYSGE-UHFFFAOYSA-N 0.000 claims 1
• MNWBXUFPFMBVCM-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methylpiperazine-1-carbonyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)C(=O)N2CCN(C)CC2)CCCC1 MNWBXUFPFMBVCM-UHFFFAOYSA-N 0.000 claims 1
• VMQJRETWXBKFCY-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-phenyl-1,3-thiazol-2-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2SC=C(N=2)C=2C=CC=CC=2)CCCC1 VMQJRETWXBKFCY-UHFFFAOYSA-N 0.000 claims 1
• UZJDDZVZJPMLLO-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-pyrrolidin-1-ylquinazolin-7-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C3N=CN=C(C3=CC=2)N2CCCC2)CCCC1 UZJDDZVZJPMLLO-UHFFFAOYSA-N 0.000 claims 1
• QGGOSLIWWJJMBY-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(6-methyl-1h-benzimidazol-2-yl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)C=2NC3=CC=C(C)C=C3N=2)CCCC1 QGGOSLIWWJJMBY-UHFFFAOYSA-N 0.000 claims 1
• JOPUPNMLOFADAU-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(oxan-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCOCC2)CCCC1 JOPUPNMLOFADAU-UHFFFAOYSA-N 0.000 claims 1
• CNGDSEMFVCVCSQ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(pyridin-4-yloxymethyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(COC=3C=CN=CC=3)CC2)CCCC1 CNGDSEMFVCVCSQ-UHFFFAOYSA-N 0.000 claims 1
• FVEWTRXIOKBQTQ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(quinoxalin-6-ylmethyl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=C4N=CC=NC4=CC=3)CC2)CCCC1 FVEWTRXIOKBQTQ-UHFFFAOYSA-N 0.000 claims 1
• LWAYZMSDMUMDJN-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC3CCN(C)CC3)CC2)CCCC1 LWAYZMSDMUMDJN-UHFFFAOYSA-N 0.000 claims 1
• ZZDNLDUTLRSLPM-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[(2,4,6-trimethylphenyl)methyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C(=CC(C)=CC=3C)C)CC2)CCCC1 ZZDNLDUTLRSLPM-UHFFFAOYSA-N 0.000 claims 1
• UIJRMPZZFZKFTL-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[(4-methoxyphenyl)methyl]piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1CN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)CC1 UIJRMPZZFZKFTL-UHFFFAOYSA-N 0.000 claims 1
• AKSWBLREBFJHIL-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[(4-methylphenyl)methyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(C)=CC=3)CC2)CCCC1 AKSWBLREBFJHIL-UHFFFAOYSA-N 0.000 claims 1
• XSLBOIWHAGEFLV-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[2-(1-methylpiperidin-4-yl)ethyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCC3CCN(C)CC3)CC2)CCCC1 XSLBOIWHAGEFLV-UHFFFAOYSA-N 0.000 claims 1
• LDKPNYLZDKRBON-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(C=CC=2)C(F)(F)F)CCCC1 LDKPNYLZDKRBON-UHFFFAOYSA-N 0.000 claims 1
• UZGKIRIPJZTYCD-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[4-(trifluoromethyl)cyclohexyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCC(CC2)C(F)(F)F)CCCC1 UZGKIRIPJZTYCD-UHFFFAOYSA-N 0.000 claims 1
• BTIKBJIRZHCRQZ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2N=CC(=CC=2)C(F)(F)F)CCCC1 BTIKBJIRZHCRQZ-UHFFFAOYSA-N 0.000 claims 1
• XSQDKLHRQSDUDL-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[6-(4-methylpiperazin-1-yl)-3,4-dihydro-1h-isoquinolin-2-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC3=CC=C(C=C3CC2)N2CCN(C)CC2)CCCC1 XSQDKLHRQSDUDL-UHFFFAOYSA-N 0.000 claims 1
• JTMCFGGKUMGQHJ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-piperazin-1-ylethanone;hydrochloride Chemical compound Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCNCC2)CCCC1 JTMCFGGKUMGQHJ-UHFFFAOYSA-N 0.000 claims 1
• AISAHQZGLHPBAW-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[(4-morpholin-4-ylphenyl)methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(=CC=2)N2CCOCC2)CCCC1 AISAHQZGLHPBAW-UHFFFAOYSA-N 0.000 claims 1
• ICIAHGAURAQOKD-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[(4-piperidin-1-ylphenyl)methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(=CC=2)N2CCCCC2)CCCC1 ICIAHGAURAQOKD-UHFFFAOYSA-N 0.000 claims 1
• YGFOFBBCWGLPPA-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[[4-(morpholin-4-ylmethyl)phenyl]methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(CN3CCOCC3)=CC=2)CCCC1 YGFOFBBCWGLPPA-UHFFFAOYSA-N 0.000 claims 1
• ZZFZQLNVQXXZFA-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(2-pyridin-2-ylpyrrolidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)C=2N=CC=CC=2)CCC1 ZZFZQLNVQXXZFA-UHFFFAOYSA-N 0.000 claims 1
• KTTPAFKRNUWRMV-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(3-pyridin-3-ylpyrrolidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2C=NC=CC=2)CCC1 KTTPAFKRNUWRMV-UHFFFAOYSA-N 0.000 claims 1
• VZWMFQUWXLCJSF-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(3-pyridin-4-ylpyrrolidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2C=CN=CC=2)CCC1 VZWMFQUWXLCJSF-UHFFFAOYSA-N 0.000 claims 1
• UESINPUZYLDXGW-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-methyl-1,4-diazepan-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(C)CCC2)CCC1 UESINPUZYLDXGW-UHFFFAOYSA-N 0.000 claims 1
• SLDHUCCFQSCFCA-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-methyl-2-phenylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CN(C)CC2)C=2C=CC=CC=2)CCC1 SLDHUCCFQSCFCA-UHFFFAOYSA-N 0.000 claims 1
• AAOVTNVEMLDWDF-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-morpholin-4-ylpiperidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCOCC2)CCC1 AAOVTNVEMLDWDF-UHFFFAOYSA-N 0.000 claims 1
• IYYPFCIJSUJPGT-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-phenylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CC=CC=2)CCC1 IYYPFCIJSUJPGT-UHFFFAOYSA-N 0.000 claims 1
• ILDAHFOQQVTKPP-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-piperidin-1-ylpiperidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCCC2)CCC1 ILDAHFOQQVTKPP-UHFFFAOYSA-N 0.000 claims 1
• NISGFTLDZPUFPE-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2N=CC=CC=2)CCC1 NISGFTLDZPUFPE-UHFFFAOYSA-N 0.000 claims 1
• BBWDOFWWOYPZOU-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-pyridin-4-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CN=CC=2)CCC1 BBWDOFWWOYPZOU-UHFFFAOYSA-N 0.000 claims 1
• MRZOBEGIVGKNSX-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-pyrimidin-2-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2N=CC=CN=2)CCC1 MRZOBEGIVGKNSX-UHFFFAOYSA-N 0.000 claims 1
• IZIOGLGFHDPLCQ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-pyrrolidin-1-ylpiperidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCC2)CCC1 IZIOGLGFHDPLCQ-UHFFFAOYSA-N 0.000 claims 1
• OFILZQKTYXCLNK-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[2-(pyridin-2-ylmethyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCCC2)CC=2N=CC=CC=2)CCC1 OFILZQKTYXCLNK-UHFFFAOYSA-N 0.000 claims 1
• RSFZTTGMADSZKR-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[2-(pyridin-2-ylmethyl)pyrrolidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)CC=2N=CC=CC=2)CCC1 RSFZTTGMADSZKR-UHFFFAOYSA-N 0.000 claims 1
• FSRXPTHBZDBKLF-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[2-[(6-methylpyridin-2-yl)methyl]pyrrolidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)CC=2N=C(C)C=CC=2)CCC1 FSRXPTHBZDBKLF-UHFFFAOYSA-N 0.000 claims 1
• UIKZSCPKJQADCD-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCC1 UIKZSCPKJQADCD-UHFFFAOYSA-N 0.000 claims 1
• HWLHJJUCWPEZOW-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C(=CC=CC=2)OC)CCC1 HWLHJJUCWPEZOW-UHFFFAOYSA-N 0.000 claims 1
• VMNRBUYRTOXASJ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCCC3)CC2)CCC1 VMNRBUYRTOXASJ-UHFFFAOYSA-N 0.000 claims 1
• KLQDJZKFAIJFSQ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCC3)CC2)CCC1 KLQDJZKFAIJFSQ-UHFFFAOYSA-N 0.000 claims 1
• SKGNJEZACQHIFT-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1N1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)CC1 SKGNJEZACQHIFT-UHFFFAOYSA-N 0.000 claims 1
• FECYEYLAEYMPIH-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCN(C)CC2)CCC1 FECYEYLAEYMPIH-UHFFFAOYSA-N 0.000 claims 1
• GQXOBUCJBARQIZ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(6-methyl-1h-benzimidazol-2-yl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)C=2NC3=CC=C(C)C=C3N=2)CCC1 GQXOBUCJBARQIZ-UHFFFAOYSA-N 0.000 claims 1
• PYPIROWRDGZTMD-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[(2,4,6-trimethylphenyl)methyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C(=CC(C)=CC=3C)C)CC2)CCC1 PYPIROWRDGZTMD-UHFFFAOYSA-N 0.000 claims 1
• BUIMMZXJEMDWQE-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[(4-methylphenyl)methyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(C)=CC=3)CC2)CCC1 BUIMMZXJEMDWQE-UHFFFAOYSA-N 0.000 claims 1
• QTENUJORZUTCJY-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(C=CC=2)C(F)(F)F)CCC1 QTENUJORZUTCJY-UHFFFAOYSA-N 0.000 claims 1
• UZXKZOTZCJIBIT-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2N=CC(=CC=2)C(F)(F)F)CCC1 UZXKZOTZCJIBIT-UHFFFAOYSA-N 0.000 claims 1
• PTZKJRQFXYITLN-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-n-[(4-piperidin-1-ylphenyl)methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(=CC=2)N2CCCCC2)CCC1 PTZKJRQFXYITLN-UHFFFAOYSA-N 0.000 claims 1
• VJIYEIOUTWJALC-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-n-[[4-(morpholin-4-ylmethyl)phenyl]methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(CN3CCOCC3)=CC=2)CCC1 VJIYEIOUTWJALC-UHFFFAOYSA-N 0.000 claims 1
• JCNJPTIZBKJLFG-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-n-[[4-[(4-methylpiperazin-1-yl)methyl]phenyl]methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(CN3CCN(C)CC3)=CC=2)CCC1 JCNJPTIZBKJLFG-UHFFFAOYSA-N 0.000 claims 1
• JNZIAZUHHUZRPW-UHFFFAOYSA-N 2-[[1-(4-methoxynaphthalen-1-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C12=CC=CC=C2C(OC)=CC=C1S(=O)(=O)N1CCCCC1COCC(=O)N(CC1)CCN1C1CCN(C)CC1 JNZIAZUHHUZRPW-UHFFFAOYSA-N 0.000 claims 1
• GGHKHUSJZWJTCU-UHFFFAOYSA-N 2-[[1-(4-methoxyphenyl)sulfonyl-2,3-dihydroindol-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C2=CC=CC=C2CC1COCC(=O)N1CCC(CCN2CCCCC2)CC1 GGHKHUSJZWJTCU-UHFFFAOYSA-N 0.000 claims 1
• DRNQLEFHCTVUAW-UHFFFAOYSA-N 2-[[1-(4-methoxyphenyl)sulfonyl-3,4-dihydro-2h-quinolin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C2=CC=CC=C2CCC1COCC(=O)N1CCN(C2CCN(C)CC2)CC1 DRNQLEFHCTVUAW-UHFFFAOYSA-N 0.000 claims 1
• IQUAYBSZCLFKRW-UHFFFAOYSA-N 2-[[1-(4-methoxyphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-phenoxyethyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCOC=3C=CC=CC=3)CC2)CCCC1 IQUAYBSZCLFKRW-UHFFFAOYSA-N 0.000 claims 1
• PRRDTXGMJPFIGP-UHFFFAOYSA-N 2-[[1-(4-methoxyphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCCC3)CC2)CCCC1 PRRDTXGMJPFIGP-UHFFFAOYSA-N 0.000 claims 1
• DWSCICRDEQYCJJ-UHFFFAOYSA-N 2-[[1-(4-methoxyphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[(3-methylphenyl)methyl]piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=C(C)C=CC=3)CC2)CCCC1 DWSCICRDEQYCJJ-UHFFFAOYSA-N 0.000 claims 1
• ILUQDFYZUSHLPC-UHFFFAOYSA-N 2-[[1-(4-methylnaphthalen-1-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=CC=C3C(C)=CC=2)CC1 ILUQDFYZUSHLPC-UHFFFAOYSA-N 0.000 claims 1
• QZCLATZXJHZAIC-UHFFFAOYSA-N 2-[[1-(5-chloro-1,3-dimethylpyrazol-4-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C2=C(N(C)N=C2C)Cl)CC1 QZCLATZXJHZAIC-UHFFFAOYSA-N 0.000 claims 1
• YYOWEGGUPQCWCW-UHFFFAOYSA-N 2-[[1-(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2N3C=CSC3=NC=2Cl)CC1 YYOWEGGUPQCWCW-UHFFFAOYSA-N 0.000 claims 1
• PIKVQEHHYKBMFM-UHFFFAOYSA-N 2-[[1-(6-methoxynaphthalen-2-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1=CC2=CC(OC)=CC=C2C=C1S(=O)(=O)N1CCCCC1COCC(=O)N(CC1)CCN1C1CCN(C)CC1 PIKVQEHHYKBMFM-UHFFFAOYSA-N 0.000 claims 1
• YPEMDPKOZGLXHY-UHFFFAOYSA-N 2-[[1-[(5-chloro-3-methyl-1-benzothiophen-2-yl)sulfonyl]piperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C2=C(C3=CC(Cl)=CC=C3S2)C)CC1 YPEMDPKOZGLXHY-UHFFFAOYSA-N 0.000 claims 1
• ONQVMPZXUDVJJD-UHFFFAOYSA-N 2-[[1-[2,5-bis(trifluoromethyl)phenyl]sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=C(C=2)C(F)(F)F)C(F)(F)F)CC1 ONQVMPZXUDVJJD-UHFFFAOYSA-N 0.000 claims 1
• HYVIFJGWBRWWEM-UHFFFAOYSA-N 2-[[1-[2,6-dichloro-4-(trifluoromethyl)phenyl]sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(=CC=2Cl)C(F)(F)F)Cl)CC1 HYVIFJGWBRWWEM-UHFFFAOYSA-N 0.000 claims 1
• ZEIUJVRVPZWDIL-UHFFFAOYSA-N 2-[[1-[2,6-dichloro-4-(trifluoromethyl)phenyl]sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC(=CC=2Cl)C(F)(F)F)Cl)CC1 ZEIUJVRVPZWDIL-UHFFFAOYSA-N 0.000 claims 1
• BCEPZPKQTIPJPA-UHFFFAOYSA-N 2-[[1-[2,6-dichloro-4-(trifluoromethyl)phenyl]sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]ethanone Chemical compound C1CN(CCCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(=CC=2Cl)C(F)(F)F)Cl)CCC1 BCEPZPKQTIPJPA-UHFFFAOYSA-N 0.000 claims 1
• RUPKBWYDAWARFQ-UHFFFAOYSA-N 2-[[1-[2-chloro-4-(trifluoromethyl)phenyl]sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(=CC=2)C(F)(F)F)Cl)CC1 RUPKBWYDAWARFQ-UHFFFAOYSA-N 0.000 claims 1
• OIRNMSFCUTUEFX-UHFFFAOYSA-N 2-[[1-[3-(2-methylphenoxy)phenyl]sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(OC=3C(=CC=CC=3)C)C=CC=2)CC1 OIRNMSFCUTUEFX-UHFFFAOYSA-N 0.000 claims 1
• HAMKYJMIDWHTPZ-UHFFFAOYSA-N 2-[[1-[4-chloro-3-(trifluoromethyl)phenyl]sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(C(Cl)=CC=2)C(F)(F)F)CC1 HAMKYJMIDWHTPZ-UHFFFAOYSA-N 0.000 claims 1
• JKDYEARPBSWSMT-UHFFFAOYSA-N 2-[[1-[5-(dimethylamino)naphthalen-1-yl]sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1=CC=C2C(N(C)C)=CC=CC2=C1S(=O)(=O)N1CCCCC1COCC(=O)N(CC1)CCN1C1CCN(C)CC1 JKDYEARPBSWSMT-UHFFFAOYSA-N 0.000 claims 1
• NIGQMSMPVPQERS-UHFFFAOYSA-N 2-[[2-(2,4-dichlorophenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[2-(piperidin-1-ylmethyl)pyrrolidin-1-yl]ethanone Chemical compound ClC1=CC(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)CN2CCCCC2)CC2=CC=CC=C2C1 NIGQMSMPVPQERS-UHFFFAOYSA-N 0.000 claims 1
• VBXXRCXQRGYVLX-UHFFFAOYSA-N 2-[[2-(2,4-dichlorophenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethanone Chemical compound C1CN(C)CCN1C1CCN(C(=O)COCC2N(CC3=CC=CC=C3C2)S(=O)(=O)C=2C(=CC(Cl)=CC=2)Cl)CC1 VBXXRCXQRGYVLX-UHFFFAOYSA-N 0.000 claims 1
• BSJPFRSGBCVQOF-UHFFFAOYSA-N 2-[[2-(3,4-dichlorophenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-(4-pyrrolidin-1-ylpiperidin-1-yl)ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCC2)CC2=CC=CC=C2C1 BSJPFRSGBCVQOF-UHFFFAOYSA-N 0.000 claims 1
• XXEKXOGWQNCSPI-UHFFFAOYSA-N 2-[[2-(3,4-dichlorophenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[2-(piperidin-1-ylmethyl)pyrrolidin-1-yl]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)CN2CCCCC2)CC2=CC=CC=C2C1 XXEKXOGWQNCSPI-UHFFFAOYSA-N 0.000 claims 1
• JJPIRFYIRMJZEA-UHFFFAOYSA-N 2-[[2-(3,4-dichlorophenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-n,n-bis[2-(diethylamino)ethyl]acetamide Chemical compound CCN(CC)CCN(CCN(CC)CC)C(=O)COCC1CC2=CC=CC=C2CN1S(=O)(=O)C1=CC=C(Cl)C(Cl)=C1 JJPIRFYIRMJZEA-UHFFFAOYSA-N 0.000 claims 1
• OESUPQKBQDLSNE-UHFFFAOYSA-N 2-[[2-(4-methoxy-2,3,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-(4-phenylpiperazin-1-yl)ethanone Chemical compound CC1=C(C)C(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CC=CC=2)CC2=CC=CC=C2C1 OESUPQKBQDLSNE-UHFFFAOYSA-N 0.000 claims 1
• SEYJJAFTBNAUJX-UHFFFAOYSA-N 2-[[2-(4-methoxy-2,3,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[2-[(6-methylpyridin-2-yl)methyl]piperidin-1-yl]ethanone Chemical compound CC1=C(C)C(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCCC2)CC=2N=C(C)C=CC=2)CC2=CC=CC=C2C1 SEYJJAFTBNAUJX-UHFFFAOYSA-N 0.000 claims 1
• SZRPRIZZIWWKCG-UHFFFAOYSA-N 2-[[2-(4-methoxy-2,3,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=C(C)C(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CC2=CC=CC=C2C1 SZRPRIZZIWWKCG-UHFFFAOYSA-N 0.000 claims 1
• QKLPKSLOLIAWSP-UHFFFAOYSA-N 2-[[2-(4-methoxy-2,3,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound CC1=C(C)C(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCCC3)CC2)CC2=CC=CC=C2C1 QKLPKSLOLIAWSP-UHFFFAOYSA-N 0.000 claims 1
• PGEBCYUVFJUEGU-UHFFFAOYSA-N 2-[[2-(4-methoxy-2,3,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethanone Chemical compound CC1=C(C)C(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCN(C)CC2)CC2=CC=CC=C2C1 PGEBCYUVFJUEGU-UHFFFAOYSA-N 0.000 claims 1
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