CA2664810A1 - Substituted sulfonamide derivatives - Google Patents

Info

Publication number

CA2664810A1

CA2664810A1 CA002664810A CA2664810A CA2664810A1 CA 2664810 A1 CA2664810 A1 CA 2664810A1 CA 002664810 A CA002664810 A CA 002664810A CA 2664810 A CA2664810 A CA 2664810A CA 2664810 A1 CA2664810 A1 CA 2664810A1

Authority

CA

Canada

Prior art keywords

methoxy

piperidin

ethanone

dimethylphenylsulfonyl

piperazin

Prior art date

2006-09-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 229940124530 sulfonamide Drugs 0.000 title abstract description 33
• 150000003456 sulfonamides Chemical class 0.000 title abstract description 33
• 238000000034 method Methods 0.000 claims abstract description 64
• 239000003814 drug Substances 0.000 claims abstract description 21
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 392
• IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims description 223
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 220
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 139
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 139
• -1 C1-10-alkyl radical Chemical class 0.000 claims description 126
• 125000003118 aryl group Chemical group 0.000 claims description 116
• 150000003254 radicals Chemical group 0.000 claims description 116
• 239000000203 mixture Substances 0.000 claims description 108
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 89
• 125000005842 heteroatom Chemical group 0.000 claims description 81
• 229910052938 sodium sulfate Inorganic materials 0.000 claims description 74
• 235000011152 sodium sulphate Nutrition 0.000 claims description 74
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 66
• 229920006395 saturated elastomer Polymers 0.000 claims description 66
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 63
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 63
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 60
• 125000000623 heterocyclic group Chemical group 0.000 claims description 58
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 47
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 46
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 45
• 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 43
• 229910052739 hydrogen Inorganic materials 0.000 claims description 40
• 238000002360 preparation method Methods 0.000 claims description 40
• 125000001072 heteroaryl group Chemical group 0.000 claims description 38
• 239000002253 acid Substances 0.000 claims description 37
• JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims description 36
• PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims description 34
• 229910052757 nitrogen Inorganic materials 0.000 claims description 33
• 230000008569 process Effects 0.000 claims description 33
• 125000004574 piperidin-2-yl group Chemical group N1C(CCCC1)* 0.000 claims description 32
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 29
• HFFXLYHRNRKAPM-UHFFFAOYSA-N 2,4,5-trichloro-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide Chemical class O1C(C)=CC(NS(=O)(=O)C=2C(=CC(Cl)=C(Cl)C=2)Cl)=N1 HFFXLYHRNRKAPM-UHFFFAOYSA-N 0.000 claims description 28
• 239000003960 organic solvent Substances 0.000 claims description 28
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 28
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 26
• 125000004076 pyridyl group Chemical group 0.000 claims description 24
• NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 24
• 229910052799 carbon Inorganic materials 0.000 claims description 22
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 22
• 125000001624 naphthyl group Chemical group 0.000 claims description 22
• CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 20
• 125000004122 cyclic group Chemical group 0.000 claims description 20
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 20
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 19
• RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 17
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 17
• 125000002757 morpholinyl group Chemical group 0.000 claims description 17
• 208000002193 Pain Diseases 0.000 claims description 16
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 16
• 125000001424 substituent group Chemical group 0.000 claims description 16
• 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 claims description 15
• 125000000217 alkyl group Chemical group 0.000 claims description 15
• 150000005840 aryl radicals Chemical class 0.000 claims description 15
• RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical group C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims description 15
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 14
• 125000003386 piperidinyl group Chemical group 0.000 claims description 14
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 14
• 238000006467 substitution reaction Methods 0.000 claims description 14
• NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 claims description 13
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 13
• JTMCFGGKUMGQHJ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-piperazin-1-ylethanone;hydrochloride Chemical compound Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCNCC2)CCCC1 JTMCFGGKUMGQHJ-UHFFFAOYSA-N 0.000 claims description 12
• FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 claims description 12
• 150000007530 organic bases Chemical class 0.000 claims description 12
• 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims description 11
• 125000004432 carbon atom Chemical group C* 0.000 claims description 11
• 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 11
• 239000000126 substance Substances 0.000 claims description 11
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 10
• 150000007513 acids Chemical class 0.000 claims description 10
• METKIMKYRPQLGS-UHFFFAOYSA-N atenolol Chemical compound CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-UHFFFAOYSA-N 0.000 claims description 10
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 10
• 235000019341 magnesium sulphate Nutrition 0.000 claims description 10
• 229910052760 oxygen Inorganic materials 0.000 claims description 10
• 150000003839 salts Chemical class 0.000 claims description 10
• 239000011734 sodium Substances 0.000 claims description 10
• 125000003107 substituted aryl group Chemical group 0.000 claims description 10
• 239000003153 chemical reaction reagent Substances 0.000 claims description 9
• 125000001544 thienyl group Chemical group 0.000 claims description 9
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 9
• QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 claims description 8
• 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 8
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 8
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 8
• 229910052717 sulfur Inorganic materials 0.000 claims description 8
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 7
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
• 125000002541 furyl group Chemical group 0.000 claims description 7
• 125000002950 monocyclic group Chemical group 0.000 claims description 7
• 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 6
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 6
• 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 6
• 206010061218 Inflammation Diseases 0.000 claims description 6
• 239000004480 active ingredient Substances 0.000 claims description 6
• 238000010640 amide synthesis reaction Methods 0.000 claims description 6
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 6
• DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 claims description 6
• 125000004193 piperazinyl group Chemical group 0.000 claims description 6
• 125000005936 piperidyl group Chemical group 0.000 claims description 6
• 125000003367 polycyclic group Polymers 0.000 claims description 6
• HJCXTWPKYQEEFG-UHFFFAOYSA-N tert-butyl 4-[2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetyl]piperazine-1-carboxylate Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C(=O)OC(C)(C)C)CCCC1 HJCXTWPKYQEEFG-UHFFFAOYSA-N 0.000 claims description 6
• CYURQSTYGXZBNQ-UHFFFAOYSA-N 1-[2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetyl]piperidin-4-one Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(=O)CC2)CCCC1 CYURQSTYGXZBNQ-UHFFFAOYSA-N 0.000 claims description 5
• FPIRBHDGWMWJEP-UHFFFAOYSA-N 1-hydroxy-7-azabenzotriazole Chemical compound C1=CN=C2N(O)N=NC2=C1 FPIRBHDGWMWJEP-UHFFFAOYSA-N 0.000 claims description 5
• 208000000094 Chronic Pain Diseases 0.000 claims description 5
• 230000001154 acute effect Effects 0.000 claims description 5
• 125000002883 imidazolyl group Chemical group 0.000 claims description 5
• 230000004054 inflammatory process Effects 0.000 claims description 5
• 208000004296 neuralgia Diseases 0.000 claims description 5
• 208000021722 neuropathic pain Diseases 0.000 claims description 5
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 5
• 125000000168 pyrrolyl group Chemical group 0.000 claims description 5
• QUZAYHMMOFRGFY-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(5-phenyl-1h-pyrazol-3-yl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2NN=C(C=2)C=2C=CC=CC=2)CCCC1 QUZAYHMMOFRGFY-UHFFFAOYSA-N 0.000 claims description 4
• AISAHQZGLHPBAW-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[(4-morpholin-4-ylphenyl)methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(=CC=2)N2CCOCC2)CCCC1 AISAHQZGLHPBAW-UHFFFAOYSA-N 0.000 claims description 4
• SVOGONNVHGTWCG-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-n-[[4-(4-methylpiperazin-1-yl)phenyl]methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(=CC=2)N2CCN(C)CC2)CCC1 SVOGONNVHGTWCG-UHFFFAOYSA-N 0.000 claims description 4
• RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims description 4
• 206010040070 Septic Shock Diseases 0.000 claims description 4
• 239000012317 TBTU Substances 0.000 claims description 4
• YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 4
• CLZISMQKJZCZDN-UHFFFAOYSA-N [benzotriazol-1-yloxy(dimethylamino)methylidene]-dimethylazanium Chemical compound C1=CC=C2N(OC(N(C)C)=[N+](C)C)N=NC2=C1 CLZISMQKJZCZDN-UHFFFAOYSA-N 0.000 claims description 4
• 208000005298 acute pain Diseases 0.000 claims description 4
• 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 4
• 239000003795 chemical substances by application Substances 0.000 claims description 4
• 125000005047 dihydroimidazolyl group Chemical group N1(CNC=C1)* 0.000 claims description 4
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
• 125000001041 indolyl group Chemical group 0.000 claims description 4
• 230000002757 inflammatory effect Effects 0.000 claims description 4
• 208000028774 intestinal disease Diseases 0.000 claims description 4
• NCINISTYDCURPN-UHFFFAOYSA-N n-benzyl-n-[2-(dimethylamino)ethyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(CCN(C)C)CC=2C=CC=CC=2)CCCC1 NCINISTYDCURPN-UHFFFAOYSA-N 0.000 claims description 4
• 230000002981 neuropathic effect Effects 0.000 claims description 4
• 229910001392 phosphorus oxide Inorganic materials 0.000 claims description 4
• 125000003373 pyrazinyl group Chemical group 0.000 claims description 4
• 125000002098 pyridazinyl group Chemical group 0.000 claims description 4
• 230000036303 septic shock Effects 0.000 claims description 4
• LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims description 3
• CJVGQWCRKVMNMD-LJAQVGFWSA-N 2-[[(3s)-2-(4-methoxy-2,6-dimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCN(CC3CCN(C)CC3)CC2)CC2=CC=CC=C2C1 CJVGQWCRKVMNMD-LJAQVGFWSA-N 0.000 claims description 3
• MUQNUVONPPPVSI-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone;hydrochloride Chemical compound Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCC3)CC2)CCCC1 MUQNUVONPPPVSI-UHFFFAOYSA-N 0.000 claims description 3
• CQDMRHKIXSUIKJ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[[4-(4-methylpiperazin-1-yl)phenyl]methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(=CC=2)N2CCN(C)CC2)CCCC1 CQDMRHKIXSUIKJ-UHFFFAOYSA-N 0.000 claims description 3
• 208000012902 Nervous system disease Diseases 0.000 claims description 3
• 208000025966 Neurological disease Diseases 0.000 claims description 3
• 208000008589 Obesity Diseases 0.000 claims description 3
• 208000025747 Rheumatic disease Diseases 0.000 claims description 3
• 239000000654 additive Substances 0.000 claims description 3
• 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 3
• 125000000609 carbazolyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 claims description 3
• 150000001735 carboxylic acids Chemical class 0.000 claims description 3
• 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 3
• 235000020824 obesity Nutrition 0.000 claims description 3
• 239000001301 oxygen Substances 0.000 claims description 3
• 150000003141 primary amines Chemical class 0.000 claims description 3
• 230000010410 reperfusion Effects 0.000 claims description 3
• 208000023504 respiratory system disease Diseases 0.000 claims description 3
• 150000003335 secondary amines Chemical class 0.000 claims description 3
• 208000011580 syndromic disease Diseases 0.000 claims description 3
• VSAISIQCTGDGPU-UHFFFAOYSA-N tetraphosphorus hexaoxide Chemical compound O1P(O2)OP3OP1OP2O3 VSAISIQCTGDGPU-UHFFFAOYSA-N 0.000 claims description 3
• 230000009278 visceral effect Effects 0.000 claims description 3
• 208000009935 visceral pain Diseases 0.000 claims description 3
• 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 claims description 2
• SLLFVLKNXABYGI-UHFFFAOYSA-N 1,2,3-benzoxadiazole Chemical compound C1=CC=C2ON=NC2=C1 SLLFVLKNXABYGI-UHFFFAOYSA-N 0.000 claims description 2
• GKGOOILMOFKQOM-UHFFFAOYSA-N 1-(3,4-dihydro-1h-2,6-naphthyridin-2-yl)-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone;hydrochloride Chemical compound Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC3=CC=NC=C3CC2)CCCC1 GKGOOILMOFKQOM-UHFFFAOYSA-N 0.000 claims description 2
• VHAUCVJHIHPFAN-UHFFFAOYSA-N 1-(3-pyridin-3-ylpyrrolidin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2C=NC=CC=2)CCCC1 VHAUCVJHIHPFAN-UHFFFAOYSA-N 0.000 claims description 2
• GAZFASPAHGWFMS-UHFFFAOYSA-N 1-(3-pyridin-4-ylpyrrolidin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2C=CN=CC=2)CCCC1 GAZFASPAHGWFMS-UHFFFAOYSA-N 0.000 claims description 2
• ULVNVZUDWUDMTK-UHFFFAOYSA-N 1-(4-benzyl-1,4-diazepan-1-yl)-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC=CC=3)CCC2)CCCC1 ULVNVZUDWUDMTK-UHFFFAOYSA-N 0.000 claims description 2
• OVUXTRAZRQORKY-UHFFFAOYSA-N 1-(4-benzylpiperazin-1-yl)-2-[[1-(2,5-dichlorothiophen-3-yl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound S1C(Cl)=CC(S(=O)(=O)N2C(CCC2)COCC(=O)N2CCN(CC=3C=CC=CC=3)CC2)=C1Cl OVUXTRAZRQORKY-UHFFFAOYSA-N 0.000 claims description 2
• SFRRCJIATFQRAU-UHFFFAOYSA-N 1-(4-benzylpiperazin-1-yl)-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC=CC=3)CC2)CCCC1 SFRRCJIATFQRAU-UHFFFAOYSA-N 0.000 claims description 2
• HMDXMZZPFPDGDD-UHFFFAOYSA-N 1-(4-benzylpiperazin-1-yl)-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC=CC=3)CC2)CCC1 HMDXMZZPFPDGDD-UHFFFAOYSA-N 0.000 claims description 2
• VHHVYWNHAVYLAR-UHFFFAOYSA-N 1-(4-pyrrolidin-1-ylpiperidin-1-yl)-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCC2)CCCC1 VHHVYWNHAVYLAR-UHFFFAOYSA-N 0.000 claims description 2
• QNQOWXDUWRCXPB-MRTLOADZSA-N 1-[(3r)-3-(dimethylamino)pyrrolidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C[C@@H](CC2)N(C)C)CCC1 QNQOWXDUWRCXPB-MRTLOADZSA-N 0.000 claims description 2
• MTDJYBHLNVJDKT-UHFFFAOYSA-N 1-[2-(5-bromopyridin-3-yl)piperidin-1-yl]-2-[[1-[3-(trifluoromethyl)phenyl]sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound FC(F)(F)C1=CC=CC(S(=O)(=O)N2C(CCCC2)COCC(=O)N2C(CCCC2)C=2C=C(Br)C=NC=2)=C1 MTDJYBHLNVJDKT-UHFFFAOYSA-N 0.000 claims description 2
• JGKLGUIMQQHXKK-UHFFFAOYSA-N 1-[2-(pyridin-2-ylmethyl)pyrrolidin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)CC=2N=CC=CC=2)CCCC1 JGKLGUIMQQHXKK-UHFFFAOYSA-N 0.000 claims description 2
• RKIKDVWRLZSCOB-UHFFFAOYSA-N 1-[2-[(3-methylpyridin-2-yl)methyl]piperidin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCCC2)CC=2C(=CC=CN=2)C)CCCC1 RKIKDVWRLZSCOB-UHFFFAOYSA-N 0.000 claims description 2
• DQMDXMWAPDVADR-UHFFFAOYSA-N 1-[2-[(4,6-dimethylpyridin-2-yl)methyl]piperidin-1-yl]-2-[[2-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound CC1=CC(C)=NC(CC2N(CCCC2)C(=O)COCC2N(CC3=CC=CC=C3C2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)=C1 DQMDXMWAPDVADR-UHFFFAOYSA-N 0.000 claims description 2
• VOLGVSUBEKDANR-UHFFFAOYSA-N 1-[2-[(5-ethylpyridin-2-yl)methyl]piperidin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound N1=CC(CC)=CC=C1CC1N(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CCCC1 VOLGVSUBEKDANR-UHFFFAOYSA-N 0.000 claims description 2
• XUCPTYRKOSKMTI-UHFFFAOYSA-N 1-[2-[(5-ethylpyridin-2-yl)methyl]pyrrolidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound N1=CC(CC)=CC=C1CC1N(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)CCC1 XUCPTYRKOSKMTI-UHFFFAOYSA-N 0.000 claims description 2
• WCGDRNVDUJWAFQ-UHFFFAOYSA-N 1-[2-[4-(dimethylamino)phenyl]azepan-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCCCC2)C=2C=CC(=CC=2)N(C)C)CCCC1 WCGDRNVDUJWAFQ-UHFFFAOYSA-N 0.000 claims description 2
• NWWSTGVSSRNEGB-UHFFFAOYSA-N 1-[2-[4-(dimethylamino)phenyl]azepan-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCCCC2)C=2C=CC(=CC=2)N(C)C)CCC1 NWWSTGVSSRNEGB-UHFFFAOYSA-N 0.000 claims description 2
• QHGCTXCLBMGEFU-UHFFFAOYSA-N 1-[2-[4-(dimethylamino)phenyl]pyrrolidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)C=2C=CC(=CC=2)N(C)C)CCCC1 QHGCTXCLBMGEFU-UHFFFAOYSA-N 0.000 claims description 2
• WBMRWBVBGRWSLJ-UHFFFAOYSA-N 1-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2SC3=CC=CC=C3N=2)CCCC1 WBMRWBVBGRWSLJ-UHFFFAOYSA-N 0.000 claims description 2
• OQUQKBMEJHEDHP-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[(1-naphthalen-1-ylsulfonylpiperidin-2-yl)methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=CC=C3C=CC=2)CC1 OQUQKBMEJHEDHP-UHFFFAOYSA-N 0.000 claims description 2
• NVPRLGXEMFZLHL-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[(1-naphthalen-2-ylsulfonyl-3,4-dihydro-2h-quinolin-2-yl)methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(C3=CC=CC=C3CC2)S(=O)(=O)C=2C=C3C=CC=CC3=CC=2)CC1 NVPRLGXEMFZLHL-UHFFFAOYSA-N 0.000 claims description 2
• XXHJFFCJDGIJDA-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[(1-naphthalen-2-ylsulfonylpiperidin-2-yl)methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C3C=CC=CC3=CC=2)CC1 XXHJFFCJDGIJDA-UHFFFAOYSA-N 0.000 claims description 2
• LLLXWOFXXXVMJT-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[(1-quinolin-8-ylsulfonylpiperidin-2-yl)methoxy]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=NC=CC=C3C=CC=2)CC1 LLLXWOFXXXVMJT-UHFFFAOYSA-N 0.000 claims description 2
• VTYPCWSQRMZRRL-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[1-[2,4,6-tri(propan-2-yl)phenyl]sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC(C)C1=CC(C(C)C)=CC(C(C)C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCCC1 VTYPCWSQRMZRRL-UHFFFAOYSA-N 0.000 claims description 2
• ACNNMIPFVRLAJD-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[1-[3-(trifluoromethyl)phenyl]sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(C=CC=2)C(F)(F)F)CC1 ACNNMIPFVRLAJD-UHFFFAOYSA-N 0.000 claims description 2
• FGSVZPVOURWQIA-UHFFFAOYSA-N 1-[4-(1h-benzimidazol-2-ylmethyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3NC4=CC=CC=C4N=3)CC2)CCCC1 FGSVZPVOURWQIA-UHFFFAOYSA-N 0.000 claims description 2
• HNNYOFDDVKPGMV-UHFFFAOYSA-N 1-[4-(2-ethoxyethyl)piperazin-1-yl]-2-[[2-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound C1CN(CCOCC)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC2=CC=CC=C2C1 HNNYOFDDVKPGMV-UHFFFAOYSA-N 0.000 claims description 2
• QQWWFHMBACDFQC-UHFFFAOYSA-N 1-[4-(3,4-dimethylphenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(C)C(C)=CC=2)CCC1 QQWWFHMBACDFQC-UHFFFAOYSA-N 0.000 claims description 2
• IJAZSBJFMWYZCD-UHFFFAOYSA-N 1-[4-(3,5-dimethoxyphenyl)piperazin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound COC1=CC(OC)=CC(N2CCN(CC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)=C1 IJAZSBJFMWYZCD-UHFFFAOYSA-N 0.000 claims description 2
• TVHAHEBJVSDIDA-UHFFFAOYSA-N 1-[4-(3,5-dimethoxyphenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(OC)C=C(OC)C=2)CCCC1 TVHAHEBJVSDIDA-UHFFFAOYSA-N 0.000 claims description 2
• UWVZRKJCJDZAHZ-UHFFFAOYSA-N 1-[4-(3,5-dimethoxyphenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(OC)C=C(OC)C=2)CCC1 UWVZRKJCJDZAHZ-UHFFFAOYSA-N 0.000 claims description 2
• CARNUSOCWBLXIO-UHFFFAOYSA-N 1-[4-(3-chlorophenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(Cl)C=CC=2)CCC1 CARNUSOCWBLXIO-UHFFFAOYSA-N 0.000 claims description 2
• QKYPZQVKYPRSKS-UHFFFAOYSA-N 1-[4-(4-fluorophenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CC(F)=CC=2)CCCC1 QKYPZQVKYPRSKS-UHFFFAOYSA-N 0.000 claims description 2
• KRZQWDAQYRBMFT-UHFFFAOYSA-N 1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-2-[[2-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound C1CN(C)CCN1C1CCN(C(=O)COCC2N(CC3=CC=CC=C3C2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC1 KRZQWDAQYRBMFT-UHFFFAOYSA-N 0.000 claims description 2
• MOAQJFOVDHUFEY-UHFFFAOYSA-N 1-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C(=CC=C(Cl)C=2)C)CCC1 MOAQJFOVDHUFEY-UHFFFAOYSA-N 0.000 claims description 2
• WZNDVCZYXZCQNO-UHFFFAOYSA-N 1-[4-(6-fluoro-3,4-dihydro-1h-isoquinolin-2-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CC3=CC=C(F)C=C3CC2)CCCC1 WZNDVCZYXZCQNO-UHFFFAOYSA-N 0.000 claims description 2
• CYGBZNANDPSJRB-UHFFFAOYSA-N 1-[4-[(1,5-dimethylpyrazol-4-yl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC3=C(N(C)N=C3)C)CC2)CCCC1 CYGBZNANDPSJRB-UHFFFAOYSA-N 0.000 claims description 2
• XXQZCDXBZLCBBT-UHFFFAOYSA-N 1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCC1CN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC1 XXQZCDXBZLCBBT-UHFFFAOYSA-N 0.000 claims description 2
• JALIVNRYQNNEIY-UHFFFAOYSA-N 1-[4-[(3,4-dichlorophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=C(Cl)C(Cl)=CC=3)CC2)CCCC1 JALIVNRYQNNEIY-UHFFFAOYSA-N 0.000 claims description 2
• KPDQTWQKCPLDJO-UHFFFAOYSA-N 1-[4-[(3,4-dichlorophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=C(Cl)C(Cl)=CC=3)CC2)CCC1 KPDQTWQKCPLDJO-UHFFFAOYSA-N 0.000 claims description 2
• CWYIPDPFVFWNDB-UHFFFAOYSA-N 1-[4-[(4-bromophenyl)methyl]piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(Br)=CC=3)CC2)CCCC1 CWYIPDPFVFWNDB-UHFFFAOYSA-N 0.000 claims description 2
• QRKGKZJPNNYYLE-UHFFFAOYSA-N 1-[4-[(4-bromophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(Br)=CC=3)CC2)CCCC1 QRKGKZJPNNYYLE-UHFFFAOYSA-N 0.000 claims description 2
• PISIDUJDDAWECE-UHFFFAOYSA-N 1-[4-[(4-bromophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(Br)=CC=3)CC2)CCC1 PISIDUJDDAWECE-UHFFFAOYSA-N 0.000 claims description 2
• RFWDSLPOIZRPTQ-UHFFFAOYSA-N 1-[4-[(4-chloro-2-phenyl-1h-imidazol-5-yl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC3=C(NC(=N3)C=3C=CC=CC=3)Cl)CC2)CCCC1 RFWDSLPOIZRPTQ-UHFFFAOYSA-N 0.000 claims description 2
• HLZXEYCBHJHXPK-UHFFFAOYSA-N 1-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(C(F)(F)F)=CN=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 HLZXEYCBHJHXPK-UHFFFAOYSA-N 0.000 claims description 2
• MBMYTBQVWRNWEJ-UHFFFAOYSA-N 1-[4-[[2-(dimethylamino)pyrimidin-5-yl]methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=NC(=NC=3)N(C)C)CC2)CCCC1 MBMYTBQVWRNWEJ-UHFFFAOYSA-N 0.000 claims description 2
• ZULBQDJWDOCBTH-UHFFFAOYSA-N 2-[2-[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]ethoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(CCOCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCCC1 ZULBQDJWDOCBTH-UHFFFAOYSA-N 0.000 claims description 2
• HIJWMGDWFFFPRM-UHFFFAOYSA-N 2-[2-[1-(4-methoxyphenyl)sulfonylpiperidin-2-yl]ethoxy]-1-[4-(2-piperidin-1-ylethyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C(CCOCC(=O)N2CCN(CCN3CCCCC3)CC2)CCCC1 HIJWMGDWFFFPRM-UHFFFAOYSA-N 0.000 claims description 2
• LUAVBURLSJTNNK-UHFFFAOYSA-N 2-[2-[1-(4-methoxyphenyl)sulfonylpiperidin-2-yl]ethoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C(CCOCC(=O)N2CCC(CCN3CCCCC3)CC2)CCCC1 LUAVBURLSJTNNK-UHFFFAOYSA-N 0.000 claims description 2
• QCPCAGLXHDUXCA-UHFFFAOYSA-N 2-[4-[2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]acetyl]-1,4-diazepan-1-yl]pyridine-3-carbonitrile Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCC2)C=2C(=CC=CN=2)C#N)CCC1 QCPCAGLXHDUXCA-UHFFFAOYSA-N 0.000 claims description 2
• PSZQVVVOIIPHQE-FTBISJDPSA-N 2-[[(2s)-1-(2-chloro-6-methylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone;hydrochloride Chemical compound Cl.CC1=CC=CC(Cl)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCC(CCN3CCCC3)CC2)CCC1 PSZQVVVOIIPHQE-FTBISJDPSA-N 0.000 claims description 2
• KZVNIKYCSXCRHL-QFIPXVFZSA-N 2-[[(2s)-1-(4-methoxy-2,6-dimethylphenyl)sulfonylazetidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CC1 KZVNIKYCSXCRHL-QFIPXVFZSA-N 0.000 claims description 2
• LTPFFIWXMIAQEI-FTBISJDPSA-N 2-[[(2s)-1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-4-yloxypiperidin-1-yl)ethanone;hydrochloride Chemical compound Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCC(CC2)OC=2C=CN=CC=2)CCCC1 LTPFFIWXMIAQEI-FTBISJDPSA-N 0.000 claims description 2
• PWVUJTOPRDSRMG-JIDHJSLPSA-N 2-[[(2s)-1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone;hydrochloride Chemical compound Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCC(CCN3CCCC3)CC2)CCC1 PWVUJTOPRDSRMG-JIDHJSLPSA-N 0.000 claims description 2
• QQAGXSRGXNDASA-SANMLTNESA-N 2-[[(3s)-2-(2,4-dichlorophenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1CN1CCN(C(=O)COC[C@H]2N(CC3=CC=CC=C3C2)S(=O)(=O)C=2C(=CC(Cl)=CC=2)Cl)CC1 QQAGXSRGXNDASA-SANMLTNESA-N 0.000 claims description 2
• VMJFPEVVOFWGNY-LJAQVGFWSA-N 2-[[(3s)-2-(4-methoxy-2,6-dimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCC(CCN3CCCC3)CC2)CC2=CC=CC=C2C1 VMJFPEVVOFWGNY-LJAQVGFWSA-N 0.000 claims description 2
• OCQQZRXTIMFUNJ-UHFFFAOYSA-N 2-[[1-(1-benzothiophen-2-ylsulfonyl)piperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2SC3=CC=CC=C3C=2)CC1 OCQQZRXTIMFUNJ-UHFFFAOYSA-N 0.000 claims description 2
• KUNOECHYRSAZOR-UHFFFAOYSA-N 2-[[1-(1-benzothiophen-3-ylsulfonyl)piperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=CC=C3SC=2)CC1 KUNOECHYRSAZOR-UHFFFAOYSA-N 0.000 claims description 2
• FNKPVVYCVDCGEU-UHFFFAOYSA-N 2-[[1-(1-benzothiophen-3-ylsulfonyl)piperidin-2-yl]methoxy]-1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1CN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=CC=C3SC=2)CC1 FNKPVVYCVDCGEU-UHFFFAOYSA-N 0.000 claims description 2
• OQBUCXCMOUVVNT-UHFFFAOYSA-N 2-[[1-(2,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(Cl)=CC=2)Cl)CC1 OQBUCXCMOUVVNT-UHFFFAOYSA-N 0.000 claims description 2
• LVGAVVPJUDXUEA-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(2-pyridin-3-ylpyrrolidin-1-yl)ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)C=2C=NC=CC=2)CCCC1 LVGAVVPJUDXUEA-UHFFFAOYSA-N 0.000 claims description 2
• XXZLWZDFSFQHHA-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-methyl-2-phenylpiperazin-1-yl)ethanone Chemical compound C1N(C)CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)C1C1=CC=CC=C1 XXZLWZDFSFQHHA-UHFFFAOYSA-N 0.000 claims description 2
• VLAPRQCGIKLFQJ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone Chemical compound FC1=CC=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 VLAPRQCGIKLFQJ-UHFFFAOYSA-N 0.000 claims description 2
• GARFXKYWXCWEKO-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound COC1=CC=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 GARFXKYWXCWEKO-UHFFFAOYSA-N 0.000 claims description 2
• UESZWIFJYPZNIF-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-phenylethyl)piperazin-1-yl]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCC=3C=CC=CC=3)CC2)CCCC1 UESZWIFJYPZNIF-UHFFFAOYSA-N 0.000 claims description 2
• CCJNUCXLJWMZNL-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCCC3)CC2)CCCC1 CCJNUCXLJWMZNL-UHFFFAOYSA-N 0.000 claims description 2
• ZORXFAZPCVKVHB-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(3,4-dimethylphenyl)piperazin-1-yl]ethanone Chemical compound C1=C(C)C(C)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 ZORXFAZPCVKVHB-UHFFFAOYSA-N 0.000 claims description 2
• UGLLUFKYOJRVQX-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(3-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound COC1=CC=CC(N2CCN(CC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=C1 UGLLUFKYOJRVQX-UHFFFAOYSA-N 0.000 claims description 2
• UJEQKKHGFIQGBC-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(F)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 UJEQKKHGFIQGBC-UHFFFAOYSA-N 0.000 claims description 2
• BAHYFOTXVDQCEL-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 BAHYFOTXVDQCEL-UHFFFAOYSA-N 0.000 claims description 2
• HRIOLRHJVGWCHE-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(6-methyl-1h-benzimidazol-2-yl)piperidin-1-yl]ethanone Chemical compound N=1C2=CC(C)=CC=C2NC=1C(CC1)CCN1C(=O)COCC1CCCCN1S(=O)(=O)C1=C(Cl)C=CC=C1Cl HRIOLRHJVGWCHE-UHFFFAOYSA-N 0.000 claims description 2
• VFHVQHSQJKDTJA-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[(4-methylphenyl)methyl]piperazin-1-yl]ethanone Chemical compound C1=CC(C)=CC=C1CN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 VFHVQHSQJKDTJA-UHFFFAOYSA-N 0.000 claims description 2
• BMTJQPUPRRSMLF-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethanone Chemical compound FC(F)(F)C1=CC=CC(N2CCN(CC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=C1 BMTJQPUPRRSMLF-UHFFFAOYSA-N 0.000 claims description 2
• XPZHGECYUIYGPC-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]ethanone Chemical compound N1=CC(C(F)(F)F)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 XPZHGECYUIYGPC-UHFFFAOYSA-N 0.000 claims description 2
• VBJNYURHIIKIMQ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-n-[4-(dimethylamino)butyl]acetamide Chemical compound CN(C)CCCCNC(=O)COCC1CCCCN1S(=O)(=O)C1=C(Cl)C=CC=C1Cl VBJNYURHIIKIMQ-UHFFFAOYSA-N 0.000 claims description 2
• MNZKPJYBASWHKI-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-n-[[4-(dimethylamino)phenyl]methyl]-n-propan-2-ylacetamide Chemical compound C1CCCN(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)C1COCC(=O)N(C(C)C)CC1=CC=C(N(C)C)C=C1 MNZKPJYBASWHKI-UHFFFAOYSA-N 0.000 claims description 2
• DSVPMZACFSDGKR-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-n-[[4-(morpholin-4-ylmethyl)phenyl]methyl]acetamide Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(CN3CCOCC3)=CC=2)CCCC1 DSVPMZACFSDGKR-UHFFFAOYSA-N 0.000 claims description 2
• PFDITDAWZWJFDV-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-n-ethyl-n-(pyridin-4-ylmethyl)acetamide Chemical compound C1CCCN(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)C1COCC(=O)N(CC)CC1=CC=NC=C1 PFDITDAWZWJFDV-UHFFFAOYSA-N 0.000 claims description 2
• YWXMQMWQAZOTPW-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[2-(pyridin-4-ylmethyl)piperidin-1-yl]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCCC2)CC=2C=CN=CC=2)CCC1 YWXMQMWQAZOTPW-UHFFFAOYSA-N 0.000 claims description 2
• JVSVMDFBQALZMW-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(3,4-dimethylphenyl)piperazin-1-yl]ethanone Chemical compound C1=C(C)C(C)=CC=C1N1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 JVSVMDFBQALZMW-UHFFFAOYSA-N 0.000 claims description 2
• DDGFUZJAWNZEMQ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(3-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound COC1=CC=CC(N2CCN(CC2)C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=C1 DDGFUZJAWNZEMQ-UHFFFAOYSA-N 0.000 claims description 2
• ZJKDJGFRJYETKI-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1N1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 ZJKDJGFRJYETKI-UHFFFAOYSA-N 0.000 claims description 2
• JDRCUGRXNAMVEJ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[(4-methoxyphenyl)methyl]piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1CN1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 JDRCUGRXNAMVEJ-UHFFFAOYSA-N 0.000 claims description 2
• BDMIDZCLVDBCBX-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[2-(2,5-dimethylpyrrol-1-yl)ethyl]piperazin-1-yl]ethanone Chemical compound CC1=CC=C(C)N1CCN1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 BDMIDZCLVDBCBX-UHFFFAOYSA-N 0.000 claims description 2
• QMJBANSRJAVMQV-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]ethanone Chemical compound C1CN(CCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCC1 QMJBANSRJAVMQV-UHFFFAOYSA-N 0.000 claims description 2
• RLCQKMHDOMCUMR-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]ethanone Chemical compound C1CN(CCCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCC1 RLCQKMHDOMCUMR-UHFFFAOYSA-N 0.000 claims description 2
• JYRZVDQMYHXKNY-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-n-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]acetamide Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(CN3CCCC3)=CC=2)CCC1 JYRZVDQMYHXKNY-UHFFFAOYSA-N 0.000 claims description 2
• MUYSWUOSVMZKDP-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonyl-2,3-dihydroindol-2-yl]methoxy]-n-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]acetamide Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C2=CC=CC=C2CC1COCC(=O)NCC(C=C1)=CC=C1CN1CCCC1 MUYSWUOSVMZKDP-UHFFFAOYSA-N 0.000 claims description 2
• WTUZAFAXPJPQQE-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonyl-3,4-dihydro-2h-quinolin-2-yl]methoxy]-n-[2-[4-(dimethylamino)cyclohexyl]ethyl]-n-methylacetamide Chemical compound C1CC(N(C)C)CCC1CCN(C)C(=O)COCC1N(S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)C2=CC=CC=C2CC1 WTUZAFAXPJPQQE-UHFFFAOYSA-N 0.000 claims description 2
• UFSZGVCKUMOUAT-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyrrolidin-1-ylpiperidin-1-yl)ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCC2)CCCC1 UFSZGVCKUMOUAT-UHFFFAOYSA-N 0.000 claims description 2
• DMSXORBRUMEPND-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-(piperidin-1-ylmethyl)morpholin-4-yl]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CC(CN3CCCCC3)OCC2)CCCC1 DMSXORBRUMEPND-UHFFFAOYSA-N 0.000 claims description 2
• NTVYCZCMTHSLFV-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCCC3)CC2)CCCC1 NTVYCZCMTHSLFV-UHFFFAOYSA-N 0.000 claims description 2
• GNVPZKORYHYGDK-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 GNVPZKORYHYGDK-UHFFFAOYSA-N 0.000 claims description 2
• TXXVJFPDATUCGR-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-n-[3-(pyrrolidin-1-ylmethyl)phenyl]acetamide Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)NC=2C=C(CN3CCCC3)C=CC=2)CCCC1 TXXVJFPDATUCGR-UHFFFAOYSA-N 0.000 claims description 2
• GXVIHLVTFQKUCQ-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]ethanone Chemical compound C1CN(CCCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)CCC1 GXVIHLVTFQKUCQ-UHFFFAOYSA-N 0.000 claims description 2
• UDYLPETXTYRNCF-UHFFFAOYSA-N 2-[[1-(3-bromophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-4-ylpiperazin-1-yl)ethanone Chemical compound BrC1=CC=CC(S(=O)(=O)N2C(CCCC2)COCC(=O)N2CCN(CC2)C=2C=CN=CC=2)=C1 UDYLPETXTYRNCF-UHFFFAOYSA-N 0.000 claims description 2
• PPVAODBCWPENLS-UHFFFAOYSA-N 2-[[1-(3-bromophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound BrC1=CC=CC(S(=O)(=O)N2C(CCCC2)COCC(=O)N2CCC(CCN3CCCC3)CC2)=C1 PPVAODBCWPENLS-UHFFFAOYSA-N 0.000 claims description 2
• ZBOKZWGMRHPJMX-UHFFFAOYSA-N 2-[[1-(4-chloro-2,5-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(Cl)=C(C)C=2)C)CC1 ZBOKZWGMRHPJMX-UHFFFAOYSA-N 0.000 claims description 2
• XIFFKZLEMPJMIO-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-methyl-1,4-diazepan-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(C)CCC2)CCCC1 XIFFKZLEMPJMIO-UHFFFAOYSA-N 0.000 claims description 2
• NPXLKXQFFZWOOU-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-methyl-2-phenylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CN(C)CC2)C=2C=CC=CC=2)CCCC1 NPXLKXQFFZWOOU-UHFFFAOYSA-N 0.000 claims description 2
• WZXZBHFTMOYBNX-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-3-yloxypiperidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)OC=2C=NC=CC=2)CCCC1 WZXZBHFTMOYBNX-UHFFFAOYSA-N 0.000 claims description 2
• VESRQTXLMFEYIP-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-3-ylpiperidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)C=2C=NC=CC=2)CCCC1 VESRQTXLMFEYIP-UHFFFAOYSA-N 0.000 claims description 2
• GZKIGMYXVNTBBM-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-4-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CN=CC=2)CCCC1 GZKIGMYXVNTBBM-UHFFFAOYSA-N 0.000 claims description 2
• OJBUWUXGBQYACH-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-4-ylpiperidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)C=2C=CN=CC=2)CCCC1 OJBUWUXGBQYACH-UHFFFAOYSA-N 0.000 claims description 2
• XPHONIPGKDSMHB-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-thieno[3,2-d]pyrimidin-4-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=3SC=CC=3N=CN=2)CCCC1 XPHONIPGKDSMHB-UHFFFAOYSA-N 0.000 claims description 2
• PIKDMGHZKYOAFK-NQCNTLBGSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[(2s)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2[C@@H](CCC2)CN2CCCC2)CCCC1 PIKDMGHZKYOAFK-NQCNTLBGSA-N 0.000 claims description 2
• WTPDHSVNURPTNC-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[3-(pyridin-3-ylmethyl)pyrrolidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC=3C=NC=CC=3)CC2)CCCC1 WTPDHSVNURPTNC-UHFFFAOYSA-N 0.000 claims description 2
• UMITVAXORSDTRI-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCCC1 UMITVAXORSDTRI-UHFFFAOYSA-N 0.000 claims description 2
• UWCSEGWAHSGKHB-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-phenylethyl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCC=3C=CC=CC=3)CC2)CCCC1 UWCSEGWAHSGKHB-UHFFFAOYSA-N 0.000 claims description 2
• RZJHLXIJXQALCY-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(3-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound COC1=CC=CC(N2CCN(CC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)=C1 RZJHLXIJXQALCY-UHFFFAOYSA-N 0.000 claims description 2
• UAUYATHVIBOUCQ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)C=2ON=C(N=2)C=2C=CN=CC=2)CCCC1 UAUYATHVIBOUCQ-UHFFFAOYSA-N 0.000 claims description 2
• ZCEPOFUXFOFFTP-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)CC1 ZCEPOFUXFOFFTP-UHFFFAOYSA-N 0.000 claims description 2
• AEOVOMDMQMWOMG-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methylcyclohexyl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCC(C)CC2)CCCC1 AEOVOMDMQMWOMG-UHFFFAOYSA-N 0.000 claims description 2
• LFYFOBQBVZSOCA-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCN(C)CC2)CCCC1 LFYFOBQBVZSOCA-UHFFFAOYSA-N 0.000 claims description 2
• IYLBAWXSOJYSGE-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethanone;hydrochloride Chemical compound Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCN(C)CC2)CCCC1 IYLBAWXSOJYSGE-UHFFFAOYSA-N 0.000 claims description 2
• VMQJRETWXBKFCY-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-phenyl-1,3-thiazol-2-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2SC=C(N=2)C=2C=CC=CC=2)CCCC1 VMQJRETWXBKFCY-UHFFFAOYSA-N 0.000 claims description 2
• JOPUPNMLOFADAU-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(oxan-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCOCC2)CCCC1 JOPUPNMLOFADAU-UHFFFAOYSA-N 0.000 claims description 2
• CNGDSEMFVCVCSQ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(pyridin-4-yloxymethyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(COC=3C=CN=CC=3)CC2)CCCC1 CNGDSEMFVCVCSQ-UHFFFAOYSA-N 0.000 claims description 2
• ZZDNLDUTLRSLPM-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[(2,4,6-trimethylphenyl)methyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C(=CC(C)=CC=3C)C)CC2)CCCC1 ZZDNLDUTLRSLPM-UHFFFAOYSA-N 0.000 claims description 2
• UIJRMPZZFZKFTL-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[(4-methoxyphenyl)methyl]piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1CN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)CC1 UIJRMPZZFZKFTL-UHFFFAOYSA-N 0.000 claims description 2
• AKSWBLREBFJHIL-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[(4-methylphenyl)methyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(C)=CC=3)CC2)CCCC1 AKSWBLREBFJHIL-UHFFFAOYSA-N 0.000 claims description 2
• UZGKIRIPJZTYCD-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[4-(trifluoromethyl)cyclohexyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCC(CC2)C(F)(F)F)CCCC1 UZGKIRIPJZTYCD-UHFFFAOYSA-N 0.000 claims description 2
• BTIKBJIRZHCRQZ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2N=CC(=CC=2)C(F)(F)F)CCCC1 BTIKBJIRZHCRQZ-UHFFFAOYSA-N 0.000 claims description 2
• XSQDKLHRQSDUDL-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[6-(4-methylpiperazin-1-yl)-3,4-dihydro-1h-isoquinolin-2-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC3=CC=C(C=C3CC2)N2CCN(C)CC2)CCCC1 XSQDKLHRQSDUDL-UHFFFAOYSA-N 0.000 claims description 2
• YCHLJXRRCBHWOO-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(1-phenyl-2-pyrrolidin-1-ylethyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC(CN2CCCC2)C=2C=CC=CC=2)CCCC1 YCHLJXRRCBHWOO-UHFFFAOYSA-N 0.000 claims description 2
• HYMKYOXYLQMBQC-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(1-pyrazol-1-ylpropan-2-yl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC(C)CN2N=CC=C2)CCCC1 HYMKYOXYLQMBQC-UHFFFAOYSA-N 0.000 claims description 2
• RKRJCWUKRIOATH-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(2-morpholin-4-ylpyridin-3-yl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C(=NC=CC=2)N2CCOCC2)CCCC1 RKRJCWUKRIOATH-UHFFFAOYSA-N 0.000 claims description 2
• IWJLKHUFCARWJB-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(2-pyrazin-2-ylethyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCC=2N=CC=NC=2)CCCC1 IWJLKHUFCARWJB-UHFFFAOYSA-N 0.000 claims description 2
• FJNMYQUGQYBMMR-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(2-pyrrolidin-1-ylethyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCN2CCCC2)CCCC1 FJNMYQUGQYBMMR-UHFFFAOYSA-N 0.000 claims description 2
• HNODVZABRQNSMR-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(3-morpholin-4-ylphenyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C=C(C=CC=2)N2CCOCC2)CCCC1 HNODVZABRQNSMR-UHFFFAOYSA-N 0.000 claims description 2
• CLSNBXDAOFXYQR-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(3-piperidin-1-ylpropyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCCN2CCCCC2)CCCC1 CLSNBXDAOFXYQR-UHFFFAOYSA-N 0.000 claims description 2
• WIOOSJPLOSVWAM-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(4-pyrrolidin-1-ylphenyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C=CC(=CC=2)N2CCCC2)CCCC1 WIOOSJPLOSVWAM-UHFFFAOYSA-N 0.000 claims description 2
• QXWUUOBWTPKCQK-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(6-morpholin-4-ylpyridin-3-yl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C=NC(=CC=2)N2CCOCC2)CCCC1 QXWUUOBWTPKCQK-UHFFFAOYSA-N 0.000 claims description 2
• LVUKNIIOADBKSB-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(pyridin-3-ylmethyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=NC=CC=2)CCCC1 LVUKNIIOADBKSB-UHFFFAOYSA-N 0.000 claims description 2
• DBFOJTAKDFPZDC-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[(2-pyrazin-2-yloxyphenyl)methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C(=CC=CC=2)OC=2N=CC=NC=2)CCCC1 DBFOJTAKDFPZDC-UHFFFAOYSA-N 0.000 claims description 2
• QGJGLZHBWVAWDI-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[(3-morpholin-4-ylphenyl)methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=C(C=CC=2)N2CCOCC2)CCCC1 QGJGLZHBWVAWDI-UHFFFAOYSA-N 0.000 claims description 2
• GIBAWYTUWWLEIX-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[(3-piperidin-1-ylphenyl)methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=C(C=CC=2)N2CCCCC2)CCCC1 GIBAWYTUWWLEIX-UHFFFAOYSA-N 0.000 claims description 2
• FLTJKGRAPDHUJT-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[(3-pyrazin-2-yloxyphenyl)methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=C(OC=3N=CC=NC=3)C=CC=2)CCCC1 FLTJKGRAPDHUJT-UHFFFAOYSA-N 0.000 claims description 2
• ICIAHGAURAQOKD-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[(4-piperidin-1-ylphenyl)methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(=CC=2)N2CCCCC2)CCCC1 ICIAHGAURAQOKD-UHFFFAOYSA-N 0.000 claims description 2
• HBUSNCGKYMPDGP-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[(4-pyrazin-2-yloxyphenyl)methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(OC=3N=CC=NC=3)=CC=2)CCCC1 HBUSNCGKYMPDGP-UHFFFAOYSA-N 0.000 claims description 2
• IMUIVKWNYREWMU-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[2-(4-methoxyphenyl)-2-pyrrolidin-1-ylethyl]acetamide Chemical compound C1=CC(OC)=CC=C1C(N1CCCC1)CNC(=O)COCC1N(S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)CCCC1 IMUIVKWNYREWMU-UHFFFAOYSA-N 0.000 claims description 2
• PCAKWBGBBNLOTP-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[2-(4-methylpiperazin-1-yl)-1-phenylethyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC(CN2CCN(C)CC2)C=2C=CC=CC=2)CCCC1 PCAKWBGBBNLOTP-UHFFFAOYSA-N 0.000 claims description 2
• ADTURJIBELIFGN-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[2-(4-methylpiperazin-1-yl)ethyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCN2CCN(C)CC2)CCCC1 ADTURJIBELIFGN-UHFFFAOYSA-N 0.000 claims description 2
• QUONOPZUFSZVJY-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[2-(5-methylpyrazol-1-yl)ethyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCN2C(=CC=N2)C)CCCC1 QUONOPZUFSZVJY-UHFFFAOYSA-N 0.000 claims description 2
• HEOYBERRZVGZDS-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[3-(piperidin-1-ylmethyl)phenyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C=C(CN3CCCCC3)C=CC=2)CCCC1 HEOYBERRZVGZDS-UHFFFAOYSA-N 0.000 claims description 2
• TWCCEZVKYPVDKC-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[4-(2-methylimidazol-1-yl)phenyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C=CC(=CC=2)N2C(=NC=C2)C)CCCC1 TWCCEZVKYPVDKC-UHFFFAOYSA-N 0.000 claims description 2
• FDOONQUZUCUMLA-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[4-(piperidin-1-ylmethyl)phenyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C=CC(CN3CCCCC3)=CC=2)CCCC1 FDOONQUZUCUMLA-UHFFFAOYSA-N 0.000 claims description 2
• LKLVMBGJRVYKTR-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[5-(2-methoxyphenyl)-1h-pyrazol-3-yl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC2=NNC(=C2)C=2C(=CC=CC=2)OC)CCCC1 LKLVMBGJRVYKTR-UHFFFAOYSA-N 0.000 claims description 2
• FNXSFYMDWXHVGN-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[5-(3-methoxyphenyl)-1h-pyrazol-3-yl]acetamide Chemical compound COC1=CC=CC(C=2NN=C(NC(=O)COCC3N(CCCC3)S(=O)(=O)C=3C(=CC(OC)=CC=3C)C)C=2)=C1 FNXSFYMDWXHVGN-UHFFFAOYSA-N 0.000 claims description 2
• BUAQRGLUUOGNGY-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[5-(4-methoxyphenyl)-1h-pyrazol-3-yl]acetamide Chemical compound C1=CC(OC)=CC=C1C1=CC(NC(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)=NN1 BUAQRGLUUOGNGY-UHFFFAOYSA-N 0.000 claims description 2
• ZRUZRANHBKBEGW-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[5-(4-methylphenyl)-1h-pyrazol-3-yl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2NN=C(C=2)C=2C=CC(C)=CC=2)CCCC1 ZRUZRANHBKBEGW-UHFFFAOYSA-N 0.000 claims description 2
• WNYXOXUVXNWLJO-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[[2-(4-methylpiperazin-1-yl)phenyl]methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C(=CC=CC=2)N2CCN(C)CC2)CCCC1 WNYXOXUVXNWLJO-UHFFFAOYSA-N 0.000 claims description 2
• XBKVJWZCDKUZKI-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[[3-(4-methylpiperazin-1-yl)phenyl]methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=C(C=CC=2)N2CCN(C)CC2)CCCC1 XBKVJWZCDKUZKI-UHFFFAOYSA-N 0.000 claims description 2
• YGFOFBBCWGLPPA-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[[4-(morpholin-4-ylmethyl)phenyl]methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(CN3CCOCC3)=CC=2)CCCC1 YGFOFBBCWGLPPA-UHFFFAOYSA-N 0.000 claims description 2
• MOBCJMICSVHIGO-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[[4-(piperidin-1-ylmethyl)phenyl]methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(CN3CCCCC3)=CC=2)CCCC1 MOBCJMICSVHIGO-UHFFFAOYSA-N 0.000 claims description 2
• XJRBAIXYIYYJJG-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-methyl-n-(1-phenyl-2-pyrrolidin-1-ylethyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(C)C(CN2CCCC2)C=2C=CC=CC=2)CCCC1 XJRBAIXYIYYJJG-UHFFFAOYSA-N 0.000 claims description 2
• YLXAYHPPNVOTKU-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-methyl-n-(2-morpholin-4-yl-1-phenylethyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(C)C(CN2CCOCC2)C=2C=CC=CC=2)CCCC1 YLXAYHPPNVOTKU-UHFFFAOYSA-N 0.000 claims description 2
• DRMLVPNZFLSAQO-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-methyl-n-[2-(4-pyrrolidin-1-ylcyclohexyl)ethyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(C)CCC2CCC(CC2)N2CCCC2)CCCC1 DRMLVPNZFLSAQO-UHFFFAOYSA-N 0.000 claims description 2
• UESINPUZYLDXGW-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-methyl-1,4-diazepan-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(C)CCC2)CCC1 UESINPUZYLDXGW-UHFFFAOYSA-N 0.000 claims description 2
• SLDHUCCFQSCFCA-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-methyl-2-phenylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CN(C)CC2)C=2C=CC=CC=2)CCC1 SLDHUCCFQSCFCA-UHFFFAOYSA-N 0.000 claims description 2
• IYYPFCIJSUJPGT-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-phenylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CC=CC=2)CCC1 IYYPFCIJSUJPGT-UHFFFAOYSA-N 0.000 claims description 2
• NISGFTLDZPUFPE-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2N=CC=CC=2)CCC1 NISGFTLDZPUFPE-UHFFFAOYSA-N 0.000 claims description 2
• MRZOBEGIVGKNSX-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-pyrimidin-2-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2N=CC=CN=2)CCC1 MRZOBEGIVGKNSX-UHFFFAOYSA-N 0.000 claims description 2
• OFILZQKTYXCLNK-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[2-(pyridin-2-ylmethyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCCC2)CC=2N=CC=CC=2)CCC1 OFILZQKTYXCLNK-UHFFFAOYSA-N 0.000 claims description 2
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• FFDHADPJEBCTRI-UHFFFAOYSA-N n-(2-pyrrolidin-1-ylethyl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]acetamide Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)NCCN2CCCC2)CCC1 FFDHADPJEBCTRI-UHFFFAOYSA-N 0.000 claims description 2
• JJDJZIYQTFCPBO-UHFFFAOYSA-N n-(3-chloro-4-morpholin-4-ylphenyl)-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C=C(Cl)C(N3CCOCC3)=CC=2)CCC1 JJDJZIYQTFCPBO-UHFFFAOYSA-N 0.000 claims description 2
• BFLWZNBGOCOMRX-UHFFFAOYSA-N n-(3-imidazol-1-ylpropyl)-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCCN2C=NC=C2)CCCC1 BFLWZNBGOCOMRX-UHFFFAOYSA-N 0.000 claims description 2
• ZBIXBKDWJSCKNG-UHFFFAOYSA-N n-[(1-benzylpiperidin-3-yl)methyl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC2CN(CC=3C=CC=CC=3)CCC2)CCCC1 ZBIXBKDWJSCKNG-UHFFFAOYSA-N 0.000 claims description 2
• YRCBVLLHLDFRKI-UHFFFAOYSA-N n-[(1-benzylpiperidin-3-yl)methyl]-2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]acetamide Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)NCC2CN(CC=3C=CC=CC=3)CCC2)CCC1 YRCBVLLHLDFRKI-UHFFFAOYSA-N 0.000 claims description 2
• QQOWCQLMAUBMAK-UHFFFAOYSA-N n-[(1-benzylpiperidin-3-yl)methyl]-2-[[1-(3,4-dichlorophenyl)sulfonyl-2,3-dihydroindol-2-yl]methoxy]acetamide Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C2=CC=CC=C2CC1COCC(=O)NCC1CN(CC=2C=CC=CC=2)CCC1 QQOWCQLMAUBMAK-UHFFFAOYSA-N 0.000 claims description 2
• NCRMFJCGEILGPY-UHFFFAOYSA-N n-[(1-benzylpiperidin-3-yl)methyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC2CN(CC=3C=CC=CC=3)CCC2)CCCC1 NCRMFJCGEILGPY-UHFFFAOYSA-N 0.000 claims description 2
• WKXFTTALYTWNDM-UHFFFAOYSA-N n-[(1-benzylpiperidin-3-yl)methyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC2CN(CC=3C=CC=CC=3)CCC2)CCC1 WKXFTTALYTWNDM-UHFFFAOYSA-N 0.000 claims description 2
• PWCDQWCJEZXBGB-UHFFFAOYSA-N n-[(1-benzylpyrrolidin-3-yl)methyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC2CN(CC=3C=CC=CC=3)CC2)CCCC1 PWCDQWCJEZXBGB-UHFFFAOYSA-N 0.000 claims description 2
• YWYGSYAFBOBAKG-SKCDSABHSA-N n-[(3s)-1-benzylpyrrolidin-3-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-n-methylacetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(C)[C@@H]2CN(CC=3C=CC=CC=3)CC2)CCC1 YWYGSYAFBOBAKG-SKCDSABHSA-N 0.000 claims description 2
• HHSWMKKBMZYPDP-NQCNTLBGSA-N n-[(3s)-1-benzylpyrrolidin-3-yl]-n-methyl-2-[[1-[2-(trifluoromethyl)phenyl]sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound C([C@@H](C1)N(C)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2)C(F)(F)F)CN1CC1=CC=CC=C1 HHSWMKKBMZYPDP-NQCNTLBGSA-N 0.000 claims description 2
• CAWIONOQUBQKJM-UHFFFAOYSA-N n-[(4-morpholin-4-ylphenyl)methyl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(=CC=2)N2CCOCC2)CCCC1 CAWIONOQUBQKJM-UHFFFAOYSA-N 0.000 claims description 2
• YBNXJHSWHIKEMG-UHFFFAOYSA-N n-[2-(1h-indol-3-yl)ethyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCC=2C3=CC=CC=C3NC=2)CCCC1 YBNXJHSWHIKEMG-UHFFFAOYSA-N 0.000 claims description 2
• SZJWAODYVKCJLC-UHFFFAOYSA-N n-[2-(2-chlorophenyl)-2-morpholin-4-ylethyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC(N2CCOCC2)C=2C(=CC=CC=2)Cl)CCCC1 SZJWAODYVKCJLC-UHFFFAOYSA-N 0.000 claims description 2
• GGQMRYLZNLUJRG-UHFFFAOYSA-N n-[2-(4-benzylpiperazin-1-yl)ethyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCN2CCN(CC=3C=CC=CC=3)CC2)CCCC1 GGQMRYLZNLUJRG-UHFFFAOYSA-N 0.000 claims description 2
• SRSRNKXYXGDWAP-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-n-ethyl-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CCN(CC)CCN(CC)C(=O)COCC1CCCCN1S(=O)(=O)C1=C(C)C=C(OC)C=C1C SRSRNKXYXGDWAP-UHFFFAOYSA-N 0.000 claims description 2
• UXZWLTOKODZROY-UHFFFAOYSA-N n-[2-(dimethylamino)-1-phenylethyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC(CN(C)C)C=2C=CC=CC=2)CCCC1 UXZWLTOKODZROY-UHFFFAOYSA-N 0.000 claims description 2
• GVUVWQGTQLZFEG-UHFFFAOYSA-N n-[2-(dimethylamino)-2-[4-(trifluoromethyl)phenyl]ethyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC(N(C)C)C=2C=CC(=CC=2)C(F)(F)F)CCC1 GVUVWQGTQLZFEG-UHFFFAOYSA-N 0.000 claims description 2
• OMKUZLFDFACCAK-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-methylacetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(C)CCN(C)C)CCCC1 OMKUZLFDFACCAK-UHFFFAOYSA-N 0.000 claims description 2
• KUHYZGIUWHJUIL-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCN(C)C)CCCC1 KUHYZGIUWHJUIL-UHFFFAOYSA-N 0.000 claims description 2
• IIBBRGMABHWALS-UHFFFAOYSA-N n-[2-[4-(dimethylamino)cyclohexyl]ethyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-methylacetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(C)CCC2CCC(CC2)N(C)C)CCCC1 IIBBRGMABHWALS-UHFFFAOYSA-N 0.000 claims description 2
• VZXXIKXXRMQICC-UHFFFAOYSA-N n-[3-(2,6-dimethylpiperidin-1-yl)propyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCCN2C(CCCC2C)C)CCCC1 VZXXIKXXRMQICC-UHFFFAOYSA-N 0.000 claims description 2
• BXYNCRONKWWDHC-UHFFFAOYSA-N n-[3-(4-benzylpiperazin-1-yl)propyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCCN2CCN(CC=3C=CC=CC=3)CC2)CCCC1 BXYNCRONKWWDHC-UHFFFAOYSA-N 0.000 claims description 2
• ISCUDHOXIUTFGT-UHFFFAOYSA-N n-[3-(4-benzylpiperazin-1-yl)propyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCCN2CCN(CC=3C=CC=CC=3)CC2)CCC1 ISCUDHOXIUTFGT-UHFFFAOYSA-N 0.000 claims description 2
• NUXHORWGQZNLAZ-UHFFFAOYSA-N n-[3-(4-ethylpiperazin-1-yl)propyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound C1CN(CC)CCN1CCCNC(=O)COCC1N(S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)CCCC1 NUXHORWGQZNLAZ-UHFFFAOYSA-N 0.000 claims description 2
• XTYZMKFAUFMELK-UHFFFAOYSA-N n-[3-(n-ethylanilino)propyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound C=1C=CC=CC=1N(CC)CCCNC(=O)COCC1CCCCN1S(=O)(=O)C1=C(C)C=C(OC)C=C1C XTYZMKFAUFMELK-UHFFFAOYSA-N 0.000 claims description 2
• BXRHLKBKANAPAV-UHFFFAOYSA-N n-[4-(2-methylimidazol-1-yl)phenyl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=NC=CN1C(C=C1)=CC=C1NC(=O)COCC1N(S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CCCC1 BXRHLKBKANAPAV-UHFFFAOYSA-N 0.000 claims description 2
• GTBGTWZRYJWNIS-UHFFFAOYSA-N n-[4-(3,4-dimethoxyphenyl)-1h-pyrazol-5-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC2=C(C=NN2)C=2C=C(OC)C(OC)=CC=2)CCCC1 GTBGTWZRYJWNIS-UHFFFAOYSA-N 0.000 claims description 2
• LVBLRZJMOJXRGF-UHFFFAOYSA-N n-[4-(4-ethylpiperazin-1-yl)phenyl]-2-[[1-(4-methoxyphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound C1CN(CC)CCN1C(C=C1)=CC=C1NC(=O)COCC1N(S(=O)(=O)C=2C=CC(OC)=CC=2)CCCC1 LVBLRZJMOJXRGF-UHFFFAOYSA-N 0.000 claims description 2
• VIFJZMXYLJLZFK-UHFFFAOYSA-N n-[4-(dimethylamino)butyl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]acetamide Chemical compound CN(C)CCCCNC(=O)COCC1CCCN1S(=O)(=O)C1=C(Cl)C=C(Cl)C=C1Cl VIFJZMXYLJLZFK-UHFFFAOYSA-N 0.000 claims description 2
• GKJVWDSWBHVJQB-UHFFFAOYSA-N n-[4-(imidazol-1-ylmethyl)phenyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C=CC(CN3C=NC=C3)=CC=2)CCCC1 GKJVWDSWBHVJQB-UHFFFAOYSA-N 0.000 claims description 2
• GIEVFCKLXXGIRW-UHFFFAOYSA-N n-[5-(dimethylamino)pentyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCCCCN(C)C)CCCC1 GIEVFCKLXXGIRW-UHFFFAOYSA-N 0.000 claims description 2
• ORMSKUXDUQBHKC-UHFFFAOYSA-N n-[[2-(4-methylpiperazin-1-yl)phenyl]methyl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound C1CN(C)CCN1C1=CC=CC=C1CNC(=O)COCC1N(S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CCCC1 ORMSKUXDUQBHKC-UHFFFAOYSA-N 0.000 claims description 2
• AKFLOMUCGIRNIA-UHFFFAOYSA-N n-[[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]methyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-methylacetamide;hydrochloride Chemical compound Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(C)CC=2C=CC(=CC=2)C=2NCCN=2)CCCC1 AKFLOMUCGIRNIA-UHFFFAOYSA-N 0.000 claims description 2
• YRXZRLJPUTWNOU-UHFFFAOYSA-N n-[[4-(4-methylpiperazin-1-yl)phenyl]methyl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1CNC(=O)COCC1N(S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CCCC1 YRXZRLJPUTWNOU-UHFFFAOYSA-N 0.000 claims description 2
• MTUPLKXASZIKEQ-UHFFFAOYSA-N n-[[4-(dimethylamino)phenyl]methyl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]acetamide Chemical compound C1=CC(N(C)C)=CC=C1CNC(=O)COCC1N(S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CCC1 MTUPLKXASZIKEQ-UHFFFAOYSA-N 0.000 claims description 2
• IQRUMRHEXSKAHM-UHFFFAOYSA-N n-[[4-(dimethylamino)phenyl]methyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-propan-2-ylacetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(CC=2C=CC(=CC=2)N(C)C)C(C)C)CCCC1 IQRUMRHEXSKAHM-UHFFFAOYSA-N 0.000 claims description 2
• VYVLBERQDNTKSL-UHFFFAOYSA-N n-[[4-(dimethylamino)phenyl]methyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(=CC=2)N(C)C)CCCC1 VYVLBERQDNTKSL-UHFFFAOYSA-N 0.000 claims description 2
• GPUGIWGALMMHHW-UHFFFAOYSA-N n-[[4-(dimethylamino)phenyl]methyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(=CC=2)N(C)C)CCC1 GPUGIWGALMMHHW-UHFFFAOYSA-N 0.000 claims description 2
• KRCIVLMOIAYGPH-UHFFFAOYSA-N n-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-2-[[2-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]acetamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(CN3CCCC3)=CC=2)CC2=CC=CC=C2C1 KRCIVLMOIAYGPH-UHFFFAOYSA-N 0.000 claims description 2
• DVSIFMCOOQRSCO-UHFFFAOYSA-N n-[[4-[(4-methylpiperazin-1-yl)methyl]phenyl]methyl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound C1CN(C)CCN1CC(C=C1)=CC=C1CNC(=O)COCC1N(S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CCCC1 DVSIFMCOOQRSCO-UHFFFAOYSA-N 0.000 claims description 2
• DHBMVLKQFGSJAG-UHFFFAOYSA-N n-[[4-[(dimethylamino)methyl]phenyl]methyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(CN(C)C)=CC=2)CCCC1 DHBMVLKQFGSJAG-UHFFFAOYSA-N 0.000 claims description 2
• JDRGMSJDCXNLIE-UHFFFAOYSA-N n-benzyl-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-n-[2-(dimethylamino)ethyl]acetamide Chemical compound C1CCCN(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)C1COCC(=O)N(CCN(C)C)CC1=CC=CC=C1 JDRGMSJDCXNLIE-UHFFFAOYSA-N 0.000 claims description 2
• VXPDMQZWQQXGIF-UHFFFAOYSA-N n-benzyl-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(4-methylpyridin-2-yl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(CC=2C=CC=CC=2)C=2N=CC=C(C)C=2)CCCC1 VXPDMQZWQQXGIF-UHFFFAOYSA-N 0.000 claims description 2
• IVZJDENVRODIBH-UHFFFAOYSA-N n-benzyl-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(6-methylpyridin-2-yl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(CC=2C=CC=CC=2)C=2N=C(C)C=CC=2)CCCC1 IVZJDENVRODIBH-UHFFFAOYSA-N 0.000 claims description 2
• HEVWACNTPULHRO-UHFFFAOYSA-N n-benzyl-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-n-(4-methylpyridin-2-yl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(CC=2C=CC=CC=2)C=2N=CC=C(C)C=2)CCC1 HEVWACNTPULHRO-UHFFFAOYSA-N 0.000 claims description 2
• ZFGKFTQAWSFYIO-UHFFFAOYSA-N n-ethyl-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(pyridin-4-ylmethyl)acetamide Chemical compound C1CCCN(S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)C1COCC(=O)N(CC)CC1=CC=NC=C1 ZFGKFTQAWSFYIO-UHFFFAOYSA-N 0.000 claims description 2
• CRIRULVSLIDJDK-UHFFFAOYSA-N n-ethyl-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-n-(pyridin-4-ylmethyl)acetamide Chemical compound C1CCN(S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)C1COCC(=O)N(CC)CC1=CC=NC=C1 CRIRULVSLIDJDK-UHFFFAOYSA-N 0.000 claims description 2
• PYOCFOFBRBPDEU-UHFFFAOYSA-N n-isoquinolin-5-yl-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C3=CC=NC=C3C=CC=2)CCCC1 PYOCFOFBRBPDEU-UHFFFAOYSA-N 0.000 claims description 2
• KGAYLZALPOXRCL-UHFFFAOYSA-N n-methyl-n-(2-pyridin-4-ylethyl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound C1CCCN(S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)C1COCC(=O)N(C)CCC1=CC=NC=C1 KGAYLZALPOXRCL-UHFFFAOYSA-N 0.000 claims description 2
• 125000004434 sulfur atom Chemical group 0.000 claims description 2
• 229930192474 thiophene Natural products 0.000 claims description 2
• 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 3
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
• ZDWPUHLBPLODAW-UHFFFAOYSA-N 1-(4-benzyl-1,4-diazepan-1-yl)-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC=CC=3)CCC2)CCCC1 ZDWPUHLBPLODAW-UHFFFAOYSA-N 0.000 claims 1
• UTYRGZCTJSLTQS-UHFFFAOYSA-N 1-(4-benzyl-1,4-diazepan-1-yl)-2-[[2-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC=CC=3)CCC2)CC2=CC=CC=C2C1 UTYRGZCTJSLTQS-UHFFFAOYSA-N 0.000 claims 1
• YREDJAXBVYZSHP-UHFFFAOYSA-N 1-(4-benzyl-1,4-diazepan-1-yl)-2-[[2-(2,4-dichlorophenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC=CC=3)CCC2)CC2=CC=CC=C2C1 YREDJAXBVYZSHP-UHFFFAOYSA-N 0.000 claims 1
• HLWZVDXQMCCUAF-UHFFFAOYSA-N 1-(4-benzylpiperazin-1-yl)-2-[[1-(4-chloro-2,5-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1=C(Cl)C(C)=CC(S(=O)(=O)N2C(CCCC2)COCC(=O)N2CCN(CC=3C=CC=CC=3)CC2)=C1C HLWZVDXQMCCUAF-UHFFFAOYSA-N 0.000 claims 1
• AHIKJJVWZJKDEN-UHFFFAOYSA-N 1-(4-ethylpiperazin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1CN(CC)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CCC1 AHIKJJVWZJKDEN-UHFFFAOYSA-N 0.000 claims 1
• LZILPWNGHCMHKN-UHFFFAOYSA-N 1-(4-ethylpiperazin-1-yl)-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1CN(CC)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)CCC1 LZILPWNGHCMHKN-UHFFFAOYSA-N 0.000 claims 1
• AEXAKVSCMWIFNA-UHFFFAOYSA-N 1-(4-methylpiperazin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CCCC1 AEXAKVSCMWIFNA-UHFFFAOYSA-N 0.000 claims 1
• MSDFXJCWFDBDFJ-UHFFFAOYSA-N 1-(4-morpholin-4-ylpiperidin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCOCC2)CCC1 MSDFXJCWFDBDFJ-UHFFFAOYSA-N 0.000 claims 1
• AJFKNZKYIKHHHC-UHFFFAOYSA-N 1-(4-piperidin-1-ylpiperidin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCCC2)CCC1 AJFKNZKYIKHHHC-UHFFFAOYSA-N 0.000 claims 1
• OZKZHZGDSDWQOL-UHFFFAOYSA-N 1-(4-piperidin-1-ylpiperidin-1-yl)-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCCC2)CCCC1 OZKZHZGDSDWQOL-UHFFFAOYSA-N 0.000 claims 1
• ZVMNZWVSMJJAKH-UHFFFAOYSA-N 1-(4-pyridin-4-ylpiperazin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CN=CC=2)CCC1 ZVMNZWVSMJJAKH-UHFFFAOYSA-N 0.000 claims 1
• UVLGQAGHBGDQSX-UHFFFAOYSA-N 1-(4-pyrrolidin-1-ylpiperidin-1-yl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCC2)CCC1 UVLGQAGHBGDQSX-UHFFFAOYSA-N 0.000 claims 1
• SOWQZPBJILIBDL-UHFFFAOYSA-N 1-[2-(6-methoxypyridin-3-yl)piperidin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1=NC(OC)=CC=C1C1N(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CCCC1 SOWQZPBJILIBDL-UHFFFAOYSA-N 0.000 claims 1
• HOQUPGOXMYRORR-UHFFFAOYSA-N 1-[2-(piperidin-1-ylmethyl)pyrrolidin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)CN2CCCCC2)CCCC1 HOQUPGOXMYRORR-UHFFFAOYSA-N 0.000 claims 1
• NBYYQVPPXQKMSW-UHFFFAOYSA-N 1-[4-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CC3CCCCN3CC2)CCCC1 NBYYQVPPXQKMSW-UHFFFAOYSA-N 0.000 claims 1
• KOIMLSCWNIVYAJ-UHFFFAOYSA-N 1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=C4OCOC4=CC=3)CC2)CCC1 KOIMLSCWNIVYAJ-UHFFFAOYSA-N 0.000 claims 1
• MKCSOGWNQOZQKO-UHFFFAOYSA-N 1-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2SC3=CC=CC=C3N=2)CCCC1 MKCSOGWNQOZQKO-UHFFFAOYSA-N 0.000 claims 1
• QIUSCDIZSGRVGX-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[(2-naphthalen-2-ylsulfonyl-3,4-dihydro-1h-isoquinolin-3-yl)methoxy]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CC3=CC=CC=C3C2)S(=O)(=O)C=2C=C3C=CC=CC3=CC=2)CC1 QIUSCDIZSGRVGX-UHFFFAOYSA-N 0.000 claims 1
• MHUUPGKTWRGBQY-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[1-(2,4,5-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(Cl)=C(Cl)C=2)Cl)CC1 MHUUPGKTWRGBQY-UHFFFAOYSA-N 0.000 claims 1
• YOJXOJUIZJYACY-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CC1 YOJXOJUIZJYACY-UHFFFAOYSA-N 0.000 claims 1
• ULNBBNQRKHOXLA-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC1 ULNBBNQRKHOXLA-UHFFFAOYSA-N 0.000 claims 1
• KOSSXIWNGPDMGW-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[1-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonyl)piperidin-2-yl]methoxy]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C3CCCCC3=CC=2)CC1 KOSSXIWNGPDMGW-UHFFFAOYSA-N 0.000 claims 1
• GHSJMMFSCQOTTM-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[1-[2-(trifluoromethyl)phenyl]sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2)C(F)(F)F)CC1 GHSJMMFSCQOTTM-UHFFFAOYSA-N 0.000 claims 1
• ANGCEQCVSZCOAI-UHFFFAOYSA-N 1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-[[2-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CC3=CC=CC=C3C2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC1 ANGCEQCVSZCOAI-UHFFFAOYSA-N 0.000 claims 1
• RQMBWTPMONVHOB-UHFFFAOYSA-N 1-[4-(2-fluorophenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C(=CC=CC=2)F)CCC1 RQMBWTPMONVHOB-UHFFFAOYSA-N 0.000 claims 1
• OIDUQTUKNIHTBE-UHFFFAOYSA-N 1-[4-(2-methoxyethyl)piperazin-1-yl]-2-[[2-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound C1CN(CCOC)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC2=CC=CC=C2C1 OIDUQTUKNIHTBE-UHFFFAOYSA-N 0.000 claims 1
• UQHWBTWOWDTQMS-UHFFFAOYSA-N 1-[4-(2-phenylethyl)piperazin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCC=3C=CC=CC=3)CC2)CCC1 UQHWBTWOWDTQMS-UHFFFAOYSA-N 0.000 claims 1
• TXCLBUGFTAHQLQ-UHFFFAOYSA-N 1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCCC3)CC2)CCC1 TXCLBUGFTAHQLQ-UHFFFAOYSA-N 0.000 claims 1
• QFDCFOKUZKKIBE-UHFFFAOYSA-N 1-[4-(3,4-dichlorophenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(Cl)C(Cl)=CC=2)CCC1 QFDCFOKUZKKIBE-UHFFFAOYSA-N 0.000 claims 1
• HBZPOBFSXMHWNO-UHFFFAOYSA-N 1-[4-(3,4-dihydro-1h-2,6-naphthyridin-2-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CC3=CC=NC=C3CC2)CCCC1 HBZPOBFSXMHWNO-UHFFFAOYSA-N 0.000 claims 1
• RMQWTWVIRAWRBB-UHFFFAOYSA-N 1-[4-(3,4-dihydro-1h-pyrrolo[1,2-a]pyrazin-2-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CC3=CC=CN3CC2)CCCC1 RMQWTWVIRAWRBB-UHFFFAOYSA-N 0.000 claims 1
• MWOHDUGKKQFGAW-UHFFFAOYSA-N 1-[4-(3,4-dimethylphenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(C)C(C)=CC=2)CCCC1 MWOHDUGKKQFGAW-UHFFFAOYSA-N 0.000 claims 1
• CXAMHOOYKNNGMR-UHFFFAOYSA-N 1-[4-(3-chlorophenyl)piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC=CC(N2CCN(CC2)C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=C1 CXAMHOOYKNNGMR-UHFFFAOYSA-N 0.000 claims 1
• CCLONGXIIMZRHJ-UHFFFAOYSA-N 1-[4-(3-chlorophenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(Cl)C=CC=2)CCCC1 CCLONGXIIMZRHJ-UHFFFAOYSA-N 0.000 claims 1
• HWQQEGAYPNCAQW-UHFFFAOYSA-N 1-[4-(4-benzyl-1,3-thiazol-2-yl)piperazin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2SC=C(CC=3C=CC=CC=3)N=2)CCCC1 HWQQEGAYPNCAQW-UHFFFAOYSA-N 0.000 claims 1
• ORXFYXZWTNHPEB-UHFFFAOYSA-N 1-[4-(4-fluorophenyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CC(F)=CC=2)CCC1 ORXFYXZWTNHPEB-UHFFFAOYSA-N 0.000 claims 1
• ZHFVCDXMPIXZAR-UHFFFAOYSA-N 1-[4-(4-fluoropiperidin-1-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCC(F)CC2)CCCC1 ZHFVCDXMPIXZAR-UHFFFAOYSA-N 0.000 claims 1
• ASDZLKAONROZLQ-UHFFFAOYSA-N 1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCN1C1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CC1 ASDZLKAONROZLQ-UHFFFAOYSA-N 0.000 claims 1
• FGTMGQCWVZCCGN-UHFFFAOYSA-N 1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(C)CCN1C1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC1 FGTMGQCWVZCCGN-UHFFFAOYSA-N 0.000 claims 1
• PQWDROLKDOSWOR-UHFFFAOYSA-N 1-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC=C(Cl)C=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 PQWDROLKDOSWOR-UHFFFAOYSA-N 0.000 claims 1
• DVAPHLLAGQDTGF-UHFFFAOYSA-N 1-[4-(6,8-dihydro-5h-[1,2,4]triazolo[1,5-a]pyrazin-7-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CC3=NC=NN3CC2)CCCC1 DVAPHLLAGQDTGF-UHFFFAOYSA-N 0.000 claims 1
• GUQZOXLIBKDAQP-UHFFFAOYSA-N 1-[4-(6,8-dihydro-5h-imidazo[1,2-a]pyrazin-7-yl)piperidin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CC3=NC=CN3CC2)CCCC1 GUQZOXLIBKDAQP-UHFFFAOYSA-N 0.000 claims 1
• KGATXCDHEGAKTQ-UHFFFAOYSA-N 1-[4-(6-chloro-1,3-benzothiazol-2-yl)piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound S1C2=CC(Cl)=CC=C2N=C1N(CC1)CCN1C(=O)COCC1CCCCN1S(=O)(=O)C1=C(Cl)C=CC=C1Cl KGATXCDHEGAKTQ-UHFFFAOYSA-N 0.000 claims 1
• CKLBRXUCOFQEEN-UHFFFAOYSA-N 1-[4-(6-methyl-1h-benzimidazol-2-yl)piperidin-1-yl]-2-[[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound N=1C2=CC(C)=CC=C2NC=1C(CC1)CCN1C(=O)COCC1CCCCN1S(=O)(=O)C1=C(C)C=C(C)C=C1C CKLBRXUCOFQEEN-UHFFFAOYSA-N 0.000 claims 1
• YDOHIUDFWJJGSD-UHFFFAOYSA-N 1-[4-(cyclohexylmethyl)piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC3CCCCC3)CC2)CCCC1 YDOHIUDFWJJGSD-UHFFFAOYSA-N 0.000 claims 1
• VILUFDZSNZPRCA-UHFFFAOYSA-N 1-[4-(cyclohexylmethyl)piperazin-1-yl]-2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC3CCCCC3)CC2)CCCC1 VILUFDZSNZPRCA-UHFFFAOYSA-N 0.000 claims 1
• GHAYWJMTOHSIHE-UHFFFAOYSA-N 1-[4-(cyclohexylmethyl)piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC3CCCCC3)CC2)CCC1 GHAYWJMTOHSIHE-UHFFFAOYSA-N 0.000 claims 1
• FOHHNKPUGCCKQR-UHFFFAOYSA-N 1-[4-[(2-fluorophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C(=CC=CC=3)F)CC2)CCCC1 FOHHNKPUGCCKQR-UHFFFAOYSA-N 0.000 claims 1
• CNGYKBBPOJAYBT-UHFFFAOYSA-N 1-[4-[(2-fluorophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C(=CC=CC=3)F)CC2)CCC1 CNGYKBBPOJAYBT-UHFFFAOYSA-N 0.000 claims 1
• MQEALGADWDWVDX-UHFFFAOYSA-N 1-[4-[(4-bromophenyl)methyl]piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(Br)=CC=3)CC2)CCC1 MQEALGADWDWVDX-UHFFFAOYSA-N 0.000 claims 1
• OTSISIMQNGHKRJ-UHFFFAOYSA-N 1-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1=CC(Cl)=CC=C1CN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 OTSISIMQNGHKRJ-UHFFFAOYSA-N 0.000 claims 1
• FZFUBOJYAFVEPV-UHFFFAOYSA-N 1-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1=CC(Cl)=CC=C1CN1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 FZFUBOJYAFVEPV-UHFFFAOYSA-N 0.000 claims 1
• QSTGKAYPKISDIS-UHFFFAOYSA-N 1-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(Cl)=CC=3)CC2)CCCC1 QSTGKAYPKISDIS-UHFFFAOYSA-N 0.000 claims 1
• GXBZFTYQFYNJRP-UHFFFAOYSA-N 1-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=CC(Cl)=CC=3)CC2)CCC1 GXBZFTYQFYNJRP-UHFFFAOYSA-N 0.000 claims 1
• ASTUSRKPFRBHLR-UHFFFAOYSA-N 1-[4-[2-(2,5-dimethylpyrrol-1-yl)ethyl]piperazin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC=C(C)N1CCN1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CC1 ASTUSRKPFRBHLR-UHFFFAOYSA-N 0.000 claims 1
• MFCJXOUCJHSLDD-UHFFFAOYSA-N 1-[4-[2-(2,5-dimethylpyrrol-1-yl)ethyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCN3C(=CC=C3C)C)CC2)CCCC1 MFCJXOUCJHSLDD-UHFFFAOYSA-N 0.000 claims 1
• FAOIOUYTOPUIMZ-UHFFFAOYSA-N 1-[4-[2-(2,5-dimethylpyrrol-1-yl)ethyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCN3C(=CC=C3C)C)CC2)CCC1 FAOIOUYTOPUIMZ-UHFFFAOYSA-N 0.000 claims 1
• VJUAGTKWXSLKMG-UHFFFAOYSA-N 1-[4-[2-(2,5-dimethylpyrrol-1-yl)ethyl]piperazin-1-yl]-2-[[1-(4-methoxyphenyl)sulfonyl-2,3-dihydroindol-2-yl]methoxy]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C2=CC=CC=C2CC1COCC(=O)N1CCN(CCN2C(=CC=C2C)C)CC1 VJUAGTKWXSLKMG-UHFFFAOYSA-N 0.000 claims 1
• AHVUZZHWIYEYGN-UHFFFAOYSA-N 1-[4-[2-[di(propan-2-yl)amino]ethyl]piperazin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound C1CN(CCN(C(C)C)C(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CCCC1 AHVUZZHWIYEYGN-UHFFFAOYSA-N 0.000 claims 1
• JWSIEOHTOUYGGD-UHFFFAOYSA-N 1-[4-[2-[di(propan-2-yl)amino]ethyl]piperazin-1-yl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound C1CN(CCN(C(C)C)C(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)CCC1 JWSIEOHTOUYGGD-UHFFFAOYSA-N 0.000 claims 1
• MNBSLSJORSJMEK-UHFFFAOYSA-N 1-[4-[2-[di(propan-2-yl)amino]ethyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCN(C(C)C)C(C)C)CC2)CCC1 MNBSLSJORSJMEK-UHFFFAOYSA-N 0.000 claims 1
• IOURMDWSMIBLAY-UHFFFAOYSA-N 1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]-2-[[2-(2,4,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound C1CN(CCCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(C)=CC=2C)C)CC2=CC=CC=C2C1 IOURMDWSMIBLAY-UHFFFAOYSA-N 0.000 claims 1
• XMCFLLJPDLYIEU-UHFFFAOYSA-N 1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]-2-[[2-(4-methoxy-2,3,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]ethanone Chemical compound CC1=C(C)C(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCCN(C)C)CC2)CC2=CC=CC=C2C1 XMCFLLJPDLYIEU-UHFFFAOYSA-N 0.000 claims 1
• AOZOFDZMXHRZTJ-UHFFFAOYSA-N 1-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C(=CC(=CN=2)C(F)(F)F)Cl)CCCC1 AOZOFDZMXHRZTJ-UHFFFAOYSA-N 0.000 claims 1
• JQPBEYYDKBPGQW-UHFFFAOYSA-N 1-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C(=CC(=CN=2)C(F)(F)F)Cl)CCC1 JQPBEYYDKBPGQW-UHFFFAOYSA-N 0.000 claims 1
• PMJFHPJDXODGKN-UHFFFAOYSA-N 1-[4-[[2-(4-fluoro-n-methylanilino)pyrimidin-5-yl]methyl]piperazin-1-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=NC(=NC=3)N(C)C=3C=CC(F)=CC=3)CC2)CCCC1 PMJFHPJDXODGKN-UHFFFAOYSA-N 0.000 claims 1
• OACUQXUBWLSNCA-UHFFFAOYSA-N 2-[(1-isoquinolin-5-ylsulfonylpiperidin-2-yl)methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=NC=C3C=CC=2)CC1 OACUQXUBWLSNCA-UHFFFAOYSA-N 0.000 claims 1
• PXIVXNFODWNGIJ-UHFFFAOYSA-N 2-[(1-naphthalen-1-ylsulfonylpiperidin-2-yl)methoxy]-1-(4-pyrrolidin-1-ylpiperidin-1-yl)ethanone Chemical compound C1CCCN(S(=O)(=O)C=2C3=CC=CC=C3C=CC=2)C1COCC(=O)N(CC1)CCC1N1CCCC1 PXIVXNFODWNGIJ-UHFFFAOYSA-N 0.000 claims 1
• HYJVAKPUVOTFJS-UHFFFAOYSA-N 2-[2-[1-(4-methoxyphenyl)sulfonylpiperidin-2-yl]ethoxy]-1-[4-(2-phenylethyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C(CCOCC(=O)N2CCN(CCC=3C=CC=CC=3)CC2)CCCC1 HYJVAKPUVOTFJS-UHFFFAOYSA-N 0.000 claims 1
• SNDNJDXVHDHFSQ-UHFFFAOYSA-N 2-[4-[2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetyl]piperazin-1-yl]pyridine-3-carbonitrile Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C(=CC=CN=2)C#N)CCCC1 SNDNJDXVHDHFSQ-UHFFFAOYSA-N 0.000 claims 1
• IFVGRTTZJWKEPY-UHFFFAOYSA-N 2-[4-[2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]acetyl]piperazin-1-yl]pyridine-3-carbonitrile Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C(=CC=CN=2)C#N)CCC1 IFVGRTTZJWKEPY-UHFFFAOYSA-N 0.000 claims 1
• BWQFHVQHCZBNHA-GHVWMZMZSA-N 2-[[(2r)-1-(2-chloro-6-methylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COC[C@@H]2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2C)Cl)CC1 BWQFHVQHCZBNHA-GHVWMZMZSA-N 0.000 claims 1
• KSVJCVQLQYOACA-PPLJNSMQSA-N 2-[[(2r)-1-(4-methoxy-2,3,6-trimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.CC1=C(C)C(OC)=CC(C)=C1S(=O)(=O)N1[C@@H](COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCC1 KSVJCVQLQYOACA-PPLJNSMQSA-N 0.000 claims 1
• UMITVAXORSDTRI-PPLJNSMQSA-N 2-[[(2r)-1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@@H](COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCCC1 UMITVAXORSDTRI-PPLJNSMQSA-N 0.000 claims 1
• BWQFHVQHCZBNHA-FGJQBABTSA-N 2-[[(2s)-1-(2-chloro-6-methylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COC[C@H]2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2C)Cl)CC1 BWQFHVQHCZBNHA-FGJQBABTSA-N 0.000 claims 1
• CAWSROYGZOKUNC-IKXQUJFKSA-N 2-[[(2s)-1-(2-chloro-6-methylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1CN1CCN(C(=O)COC[C@H]2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2C)Cl)CC1 CAWSROYGZOKUNC-IKXQUJFKSA-N 0.000 claims 1
• LLRDYAYGXUHNPL-DEOSSOPVSA-N 2-[[(2s)-1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCCC1 LLRDYAYGXUHNPL-DEOSSOPVSA-N 0.000 claims 1
• UIKZSCPKJQADCD-QHCPKHFHSA-N 2-[[(2s)-1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCC1 UIKZSCPKJQADCD-QHCPKHFHSA-N 0.000 claims 1
• FUDFZLURKHNCDS-DEOSSOPVSA-N 2-[[(2s)-1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCN(CC3CCN(C)CC3)CC2)CCC1 FUDFZLURKHNCDS-DEOSSOPVSA-N 0.000 claims 1
• SIGSVHVCWVXKOT-SANMLTNESA-N 2-[[(3s)-2-(2,4-dichlorophenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound ClC1=CC(Cl)=CC=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCC(CCN3CCCC3)CC2)CC2=CC=CC=C2C1 SIGSVHVCWVXKOT-SANMLTNESA-N 0.000 claims 1
• QPHAHMLCQKOAKH-NDEPHWFRSA-N 2-[[(3s)-2-(4-methoxy-2,6-dimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CC2=CC=CC=C2C1 QPHAHMLCQKOAKH-NDEPHWFRSA-N 0.000 claims 1
• UYVWHJGJBRYSTN-MHZLTWQESA-N 2-[[(3s)-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1[C@H](COCC(=O)N2CCC(CCN3CCCC3)CC2)CC2=CC=CC=C2C1 UYVWHJGJBRYSTN-MHZLTWQESA-N 0.000 claims 1
• SLPCXDZOIZWXTJ-UHFFFAOYSA-N 2-[[1-(1-benzothiophen-3-ylsulfonyl)piperidin-2-yl]methoxy]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethanone Chemical compound C1CN(C)CCN1C1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=CC=C3SC=2)CC1 SLPCXDZOIZWXTJ-UHFFFAOYSA-N 0.000 claims 1
• UEPPUVUZZILNMX-UHFFFAOYSA-N 2-[[1-(2,3-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=C(Cl)C=CC=2)Cl)CC1 UEPPUVUZZILNMX-UHFFFAOYSA-N 0.000 claims 1
• GSCOJOOTAKPQOG-UHFFFAOYSA-N 2-[[1-(2,5-dichlorothiophen-3-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C2=C(SC(Cl)=C2)Cl)CC1 GSCOJOOTAKPQOG-UHFFFAOYSA-N 0.000 claims 1
• YTNDCRYTJVKJDU-UHFFFAOYSA-N 2-[[1-(2,5-dimethylthiophen-3-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C2=C(SC(C)=C2)C)CC1 YTNDCRYTJVKJDU-UHFFFAOYSA-N 0.000 claims 1
• CKGCRLMJEJYQPA-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(3-pyridin-4-ylpyrrolidin-1-yl)ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2C=CN=CC=2)CCCC1 CKGCRLMJEJYQPA-UHFFFAOYSA-N 0.000 claims 1
• ZHYJSGFEPXEITC-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-methyl-1,4-diazepan-1-yl)ethanone Chemical compound C1CN(C)CCCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCCC1 ZHYJSGFEPXEITC-UHFFFAOYSA-N 0.000 claims 1
• GMTFPXMRYMTELC-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-piperidin-1-ylpiperidin-1-yl)ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCCC2)CCCC1 GMTFPXMRYMTELC-UHFFFAOYSA-N 0.000 claims 1
• PKCHCYXPVJYLQN-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-2-ylpiperazin-1-yl)ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2N=CC=CC=2)CCCC1 PKCHCYXPVJYLQN-UHFFFAOYSA-N 0.000 claims 1
• KXGMBNVYRZIXLM-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-4-ylpiperazin-1-yl)ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CN=CC=2)CCCC1 KXGMBNVYRZIXLM-UHFFFAOYSA-N 0.000 claims 1
• YEYXKMIHQVKBKF-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyrrolidin-1-ylpiperidin-1-yl)ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCC2)CCCC1 YEYXKMIHQVKBKF-UHFFFAOYSA-N 0.000 claims 1
• MQYPOFBEOOYHEU-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-(pyridin-2-ylmethyl)pyrrolidin-1-yl]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)CC=2N=CC=CC=2)CCCC1 MQYPOFBEOOYHEU-UHFFFAOYSA-N 0.000 claims 1
• OACYPNOMTJCOIL-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-[(4,6-dimethylpyridin-2-yl)methyl]pyrrolidin-1-yl]ethanone Chemical compound CC1=CC(C)=NC(CC2N(CCC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=C1 OACYPNOMTJCOIL-UHFFFAOYSA-N 0.000 claims 1
• PGKOEGAHHJIBMA-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-[(6-methylpyridin-2-yl)methyl]piperidin-1-yl]ethanone Chemical compound CC1=CC=CC(CC2N(CCCC2)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=N1 PGKOEGAHHJIBMA-UHFFFAOYSA-N 0.000 claims 1
• LAOQNIXJKBRRGO-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-[4-(dimethylamino)phenyl]pyrrolidin-1-yl]ethanone Chemical compound C1=CC(N(C)C)=CC=C1C1N(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCC1 LAOQNIXJKBRRGO-UHFFFAOYSA-N 0.000 claims 1
• MHWNLPQLUCVWJJ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 MHWNLPQLUCVWJJ-UHFFFAOYSA-N 0.000 claims 1
• ISKIIZUVOZWDIQ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 ISKIIZUVOZWDIQ-UHFFFAOYSA-N 0.000 claims 1
• XLMQPRGESAWMBS-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-hydroxyethyl)piperazin-1-yl]ethanone Chemical compound C1CN(CCO)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCCC1 XLMQPRGESAWMBS-UHFFFAOYSA-N 0.000 claims 1
• ZWIFDPRVGYPPRI-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(3,5-dichloropyridin-2-yl)piperazin-1-yl]ethanone Chemical compound ClC1=CC(Cl)=CN=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 ZWIFDPRVGYPPRI-UHFFFAOYSA-N 0.000 claims 1
• KVCMTEVQLGMJEK-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethanone Chemical compound C1CN(C)CCN1C1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 KVCMTEVQLGMJEK-UHFFFAOYSA-N 0.000 claims 1
• XFLMBMJDGOISPS-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[(2-fluorophenyl)methyl]piperazin-1-yl]ethanone Chemical compound FC1=CC=CC=C1CN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 XFLMBMJDGOISPS-UHFFFAOYSA-N 0.000 claims 1
• USIISHYGQBRBKE-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[2-(2,5-dimethylpyrrol-1-yl)ethyl]piperazin-1-yl]ethanone Chemical compound CC1=CC=C(C)N1CCN1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 USIISHYGQBRBKE-UHFFFAOYSA-N 0.000 claims 1
• BCBFSBZZSNGJNF-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[2-[di(propan-2-yl)amino]ethyl]piperazin-1-yl]ethanone Chemical compound C1CN(CCN(C(C)C)C(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCCC1 BCBFSBZZSNGJNF-UHFFFAOYSA-N 0.000 claims 1
• DDERZQUZWVBXKO-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]ethanone Chemical compound C1CN(CCCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCCC1 DDERZQUZWVBXKO-UHFFFAOYSA-N 0.000 claims 1
• IAYBYFLMEBMMDF-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethanone Chemical compound C1=CC(C(F)(F)F)=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 IAYBYFLMEBMMDF-UHFFFAOYSA-N 0.000 claims 1
• CDWFLMCCXJMCRW-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-n-(2-piperidin-1-ylethyl)acetamide Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)NCCN2CCCCC2)CCCC1 CDWFLMCCXJMCRW-UHFFFAOYSA-N 0.000 claims 1
• FWOZHPMIHLBITD-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-n-[4-(2-methylimidazol-1-yl)phenyl]acetamide Chemical compound CC1=NC=CN1C(C=C1)=CC=C1NC(=O)COCC1N(S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CCCC1 FWOZHPMIHLBITD-UHFFFAOYSA-N 0.000 claims 1
• IWCDVQVMATXXJQ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-n-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]acetamide Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(CN3CCCC3)=CC=2)CCCC1 IWCDVQVMATXXJQ-UHFFFAOYSA-N 0.000 claims 1
• HMIRULGUTAEAIY-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-piperidin-1-ylpiperidin-1-yl)ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCCC2)CCC1 HMIRULGUTAEAIY-UHFFFAOYSA-N 0.000 claims 1
• LHGKPFKYTIKKFZ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 LHGKPFKYTIKKFZ-UHFFFAOYSA-N 0.000 claims 1
• PWNCORRJYFEMJP-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(2-phenylethyl)piperazin-1-yl]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCC=3C=CC=CC=3)CC2)CCC1 PWNCORRJYFEMJP-UHFFFAOYSA-N 0.000 claims 1
• DBORZRAKMDGUPJ-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCCC3)CC2)CCC1 DBORZRAKMDGUPJ-UHFFFAOYSA-N 0.000 claims 1
• LTKRKWDRHQYZMD-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]ethanone Chemical compound C1CN(C)CCN1C1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 LTKRKWDRHQYZMD-UHFFFAOYSA-N 0.000 claims 1
• XTNKOQZUVQJVSA-UHFFFAOYSA-N 2-[[1-(2,6-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[(4-methylphenyl)methyl]piperazin-1-yl]ethanone Chemical compound C1=CC(C)=CC=C1CN1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CC1 XTNKOQZUVQJVSA-UHFFFAOYSA-N 0.000 claims 1
• POGIAEQSZUKXRJ-UHFFFAOYSA-N 2-[[1-(2-chloro-6-methylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2C)Cl)CC1 POGIAEQSZUKXRJ-UHFFFAOYSA-N 0.000 claims 1
• WLQQDMJBDHXXKA-UHFFFAOYSA-N 2-[[1-(2-chloronaphthalen-1-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=CC=C3C=CC=2Cl)CC1 WLQQDMJBDHXXKA-UHFFFAOYSA-N 0.000 claims 1
• XVCLMSJGFRXVAQ-UHFFFAOYSA-N 2-[[1-(2-chlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2)Cl)CC1 XVCLMSJGFRXVAQ-UHFFFAOYSA-N 0.000 claims 1
• RAFNGJGFAUCMJK-UHFFFAOYSA-N 2-[[1-(2-methylnaphthalen-1-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=CC=C3C=CC=2C)CC1 RAFNGJGFAUCMJK-UHFFFAOYSA-N 0.000 claims 1
• AUPQRROPFURMHZ-UHFFFAOYSA-N 2-[[1-(2-methylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2)C)CC1 AUPQRROPFURMHZ-UHFFFAOYSA-N 0.000 claims 1
• RURWDWDGLCEGLA-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonyl-3,4-dihydro-2h-quinolin-2-yl]methoxy]-n-methyl-n-[2-(4-pyrrolidin-1-ylcyclohexyl)ethyl]acetamide Chemical compound C1CC2=CC=CC=C2N(S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)C1COCC(=O)N(C)CCC(CC1)CCC1N1CCCC1 RURWDWDGLCEGLA-UHFFFAOYSA-N 0.000 claims 1
• NXCXCMATZDALAR-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone Chemical compound FC1=CC=CC=C1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)CC1 NXCXCMATZDALAR-UHFFFAOYSA-N 0.000 claims 1
• AFKSSRWBNOYWPG-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]ethanone Chemical compound C1CN(CCCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)CCCC1 AFKSSRWBNOYWPG-UHFFFAOYSA-N 0.000 claims 1
• XXDIJNZIGPCEHM-UHFFFAOYSA-N 2-[[1-(3,4-dichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-phenylpiperazin-1-yl)ethanone Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CC=CC=2)CCC1 XXDIJNZIGPCEHM-UHFFFAOYSA-N 0.000 claims 1
• RZXLFXSAIYIFBO-UHFFFAOYSA-N 2-[[1-(3-bromophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(Br)C=CC=2)CC1 RZXLFXSAIYIFBO-UHFFFAOYSA-N 0.000 claims 1
• FDLIAFFQTFXWLD-UHFFFAOYSA-N 2-[[1-(4-bromo-2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(Br)=CC=2Cl)Cl)CC1 FDLIAFFQTFXWLD-UHFFFAOYSA-N 0.000 claims 1
• NDBFGWQIDYZNDG-UHFFFAOYSA-N 2-[[1-(4-bromo-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-4-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(Br)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CN=CC=2)CCCC1 NDBFGWQIDYZNDG-UHFFFAOYSA-N 0.000 claims 1
• YBTHOGNTRBLSMU-UHFFFAOYSA-N 2-[[1-(4-bromo-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(Br)=CC=2C)C)CC1 YBTHOGNTRBLSMU-UHFFFAOYSA-N 0.000 claims 1
• KFWPECDKNVGUNC-UHFFFAOYSA-N 2-[[1-(4-bromo-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(Br)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCC3)CC2)CCCC1 KFWPECDKNVGUNC-UHFFFAOYSA-N 0.000 claims 1
• NDGSUKNCWJHFNS-UHFFFAOYSA-N 2-[[1-(4-bromophenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-pyridin-4-ylpiperazin-1-yl)ethanone Chemical compound C1=CC(Br)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CN=CC=2)CCCC1 NDGSUKNCWJHFNS-UHFFFAOYSA-N 0.000 claims 1
• AKOGHCIHZXOWEB-UHFFFAOYSA-N 2-[[1-(4-bromophenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=CC(Br)=CC=2)CC1 AKOGHCIHZXOWEB-UHFFFAOYSA-N 0.000 claims 1
• KWSQMJUOHLAGPT-UHFFFAOYSA-N 2-[[1-(4-fluoro-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(F)=CC=2C)C)CC1 KWSQMJUOHLAGPT-UHFFFAOYSA-N 0.000 claims 1
• SIXPUEWATAUFSY-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(2-pyridin-2-ylpyrrolidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)C=2N=CC=CC=2)CCCC1 SIXPUEWATAUFSY-UHFFFAOYSA-N 0.000 claims 1
• LGKQILBLPCLPQJ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(3-pyridin-2-ylpyrrolidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2N=CC=CC=2)CCCC1 LGKQILBLPCLPQJ-UHFFFAOYSA-N 0.000 claims 1
• QOPJEJDHHHBTQJ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(3-pyridin-3-ylpyrrolidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2C=NC=CC=2)CCCC1 QOPJEJDHHHBTQJ-UHFFFAOYSA-N 0.000 claims 1
• XAPOWQDTWLGEFQ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(3-pyridin-4-ylpyrrolidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2C=CN=CC=2)CCCC1 XAPOWQDTWLGEFQ-UHFFFAOYSA-N 0.000 claims 1
• XVRZWBSVBVXZQT-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-methylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(C)CC2)CCCC1 XVRZWBSVBVXZQT-UHFFFAOYSA-N 0.000 claims 1
• LICUTKCPCUDLAZ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-(4-propan-2-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C(C)C)CCCC1 LICUTKCPCUDLAZ-UHFFFAOYSA-N 0.000 claims 1
• RLAMHAIURGTGCD-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-(2-morpholin-4-ylethyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCCC2)CCN2CCOCC2)CCCC1 RLAMHAIURGTGCD-UHFFFAOYSA-N 0.000 claims 1
• OWVFXMCGQMQWIR-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[2-(piperidin-1-ylmethyl)pyrrolidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)CN2CCCCC2)CCCC1 OWVFXMCGQMQWIR-UHFFFAOYSA-N 0.000 claims 1
• LLRDYAYGXUHNPL-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCCC1 LLRDYAYGXUHNPL-UHFFFAOYSA-N 0.000 claims 1
• RFTPUXZEALPYFT-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CCN3CCCCC3)CC2)CCCC1 RFTPUXZEALPYFT-UHFFFAOYSA-N 0.000 claims 1
• MNWBXUFPFMBVCM-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-methylpiperazine-1-carbonyl)piperidin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)C(=O)N2CCN(C)CC2)CCCC1 MNWBXUFPFMBVCM-UHFFFAOYSA-N 0.000 claims 1
• UZJDDZVZJPMLLO-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(4-pyrrolidin-1-ylquinazolin-7-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C3N=CN=C(C3=CC=2)N2CCCC2)CCCC1 UZJDDZVZJPMLLO-UHFFFAOYSA-N 0.000 claims 1
• FVEWTRXIOKBQTQ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(quinoxalin-6-ylmethyl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC=3C=C4N=CC=NC4=CC=3)CC2)CCCC1 FVEWTRXIOKBQTQ-UHFFFAOYSA-N 0.000 claims 1
• LWAYZMSDMUMDJN-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC3CCN(C)CC3)CC2)CCCC1 LWAYZMSDMUMDJN-UHFFFAOYSA-N 0.000 claims 1
• XSLBOIWHAGEFLV-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[2-(1-methylpiperidin-4-yl)ethyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCC3CCN(C)CC3)CC2)CCCC1 XSLBOIWHAGEFLV-UHFFFAOYSA-N 0.000 claims 1
• LDKPNYLZDKRBON-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=C(C=CC=2)C(F)(F)F)CCCC1 LDKPNYLZDKRBON-UHFFFAOYSA-N 0.000 claims 1
• BODKMZOZZSRXLG-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(2-methylquinolin-4-yl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C3=CC=CC=C3N=C(C)C=2)CCCC1 BODKMZOZZSRXLG-UHFFFAOYSA-N 0.000 claims 1
• WUFMPUQDVSGWED-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(3-morpholin-4-ylpropyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCCN2CCOCC2)CCCC1 WUFMPUQDVSGWED-UHFFFAOYSA-N 0.000 claims 1
• XLCNMCMFDCVJFX-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(3-piperidin-1-ylphenyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C=C(C=CC=2)N2CCCCC2)CCCC1 XLCNMCMFDCVJFX-UHFFFAOYSA-N 0.000 claims 1
• LKPODHDZBBLAHR-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(4-morpholin-4-ylphenyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C=CC(=CC=2)N2CCOCC2)CCCC1 LKPODHDZBBLAHR-UHFFFAOYSA-N 0.000 claims 1
• VLYYGCMMLWLAIF-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(5-methyl-1h-pyrazol-3-yl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC2=NNC(C)=C2)CCCC1 VLYYGCMMLWLAIF-UHFFFAOYSA-N 0.000 claims 1
• JZQQEVGRAIQCBD-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(5-thiophen-2-yl-1h-pyrazol-3-yl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2NN=C(C=2)C=2SC=CC=2)CCCC1 JZQQEVGRAIQCBD-UHFFFAOYSA-N 0.000 claims 1
• HAAOUKZERAVXHN-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[(2-morpholin-4-ylphenyl)methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C(=CC=CC=2)N2CCOCC2)CCCC1 HAAOUKZERAVXHN-UHFFFAOYSA-N 0.000 claims 1
• MVMYDTKOTZWMGR-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[(2-piperidin-1-ylphenyl)methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C(=CC=CC=2)N2CCCCC2)CCCC1 MVMYDTKOTZWMGR-UHFFFAOYSA-N 0.000 claims 1
• BMLJVRIJEXIAQJ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[2-(1-pyridin-4-ylpiperidin-4-yl)ethyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCCC2CCN(CC2)C=2C=CN=CC=2)CCCC1 BMLJVRIJEXIAQJ-UHFFFAOYSA-N 0.000 claims 1
• ZRBNGNHVWYRRSG-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[2-(4-methylpiperazin-1-yl)phenyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C(=CC=CC=2)N2CCN(C)CC2)CCCC1 ZRBNGNHVWYRRSG-UHFFFAOYSA-N 0.000 claims 1
• HRRMWWPNTFAUMI-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-[[4-[(4-methylpiperazin-1-yl)methyl]phenyl]methyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CC(CN3CCN(C)CC3)=CC=2)CCCC1 HRRMWWPNTFAUMI-UHFFFAOYSA-N 0.000 claims 1
• UUMKOYWDUQOIKG-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-methyl-n-(2-piperidin-1-ylethyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(C)CCN2CCCCC2)CCCC1 UUMKOYWDUQOIKG-UHFFFAOYSA-N 0.000 claims 1
• YLDHSENORVRVBO-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-methyl-n-(2-pyridin-4-ylethyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(C)CCC=2C=CN=CC=2)CCCC1 YLDHSENORVRVBO-UHFFFAOYSA-N 0.000 claims 1
• VSNPKDXFBYKQII-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-pyrimidin-4-ylacetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2N=CN=CC=2)CCCC1 VSNPKDXFBYKQII-UHFFFAOYSA-N 0.000 claims 1
• DPCIGHDIZXBRSB-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-quinolin-2-ylacetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2N=C3C=CC=CC3=CC=2)CCCC1 DPCIGHDIZXBRSB-UHFFFAOYSA-N 0.000 claims 1
• ZZFZQLNVQXXZFA-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(2-pyridin-2-ylpyrrolidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCC2)C=2N=CC=CC=2)CCC1 ZZFZQLNVQXXZFA-UHFFFAOYSA-N 0.000 claims 1
• KTTPAFKRNUWRMV-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(3-pyridin-3-ylpyrrolidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2C=NC=CC=2)CCC1 KTTPAFKRNUWRMV-UHFFFAOYSA-N 0.000 claims 1
• VZWMFQUWXLCJSF-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(3-pyridin-4-ylpyrrolidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CC(CC2)C=2C=CN=CC=2)CCC1 VZWMFQUWXLCJSF-UHFFFAOYSA-N 0.000 claims 1
• AAOVTNVEMLDWDF-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-morpholin-4-ylpiperidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCOCC2)CCC1 AAOVTNVEMLDWDF-UHFFFAOYSA-N 0.000 claims 1
• BBWDOFWWOYPZOU-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-pyridin-4-ylpiperazin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2C=CN=CC=2)CCC1 BBWDOFWWOYPZOU-UHFFFAOYSA-N 0.000 claims 1
• IZIOGLGFHDPLCQ-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-(4-pyrrolidin-1-ylpiperidin-1-yl)ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCC2)CCC1 IZIOGLGFHDPLCQ-UHFFFAOYSA-N 0.000 claims 1
• UIKZSCPKJQADCD-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CCC1 UIKZSCPKJQADCD-UHFFFAOYSA-N 0.000 claims 1
• RQGVJLDCXYEHBS-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(3-methoxyphenyl)piperazin-1-yl]ethanone Chemical compound COC1=CC=CC(N2CCN(CC2)C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC(OC)=CC=2C)C)=C1 RQGVJLDCXYEHBS-UHFFFAOYSA-N 0.000 claims 1
• ONILCZYTWBEWPD-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-n-(1-methylbenzimidazol-2-yl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2N(C3=CC=CC=C3N=2)C)CCC1 ONILCZYTWBEWPD-UHFFFAOYSA-N 0.000 claims 1
• NWUOGQOJSSKFOC-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-n-(1-methylindazol-6-yl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C=C3N(C)N=CC3=CC=2)CCC1 NWUOGQOJSSKFOC-UHFFFAOYSA-N 0.000 claims 1
• NWYZBZVHWZVREU-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-n-(1-phenyl-2-pyrrolidin-1-ylethyl)acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC(CN2CCCC2)C=2C=CC=CC=2)CCC1 NWYZBZVHWZVREU-UHFFFAOYSA-N 0.000 claims 1
• LXOHPNYRHXGOTA-UHFFFAOYSA-N 2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpyrrolidin-2-yl]methoxy]-n-[4-[2-(1-methylbenzimidazol-2-yl)ethyl]phenyl]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC=2C=CC(CCC=3N(C4=CC=CC=C4N=3)C)=CC=2)CCC1 LXOHPNYRHXGOTA-UHFFFAOYSA-N 0.000 claims 1
• JNZIAZUHHUZRPW-UHFFFAOYSA-N 2-[[1-(4-methoxynaphthalen-1-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C12=CC=CC=C2C(OC)=CC=C1S(=O)(=O)N1CCCCC1COCC(=O)N(CC1)CCN1C1CCN(C)CC1 JNZIAZUHHUZRPW-UHFFFAOYSA-N 0.000 claims 1
• GGHKHUSJZWJTCU-UHFFFAOYSA-N 2-[[1-(4-methoxyphenyl)sulfonyl-2,3-dihydroindol-2-yl]methoxy]-1-[4-(2-piperidin-1-ylethyl)piperidin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C2=CC=CC=C2CC1COCC(=O)N1CCC(CCN2CCCCC2)CC1 GGHKHUSJZWJTCU-UHFFFAOYSA-N 0.000 claims 1
• DRNQLEFHCTVUAW-UHFFFAOYSA-N 2-[[1-(4-methoxyphenyl)sulfonyl-3,4-dihydro-2h-quinolin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C2=CC=CC=C2CCC1COCC(=O)N1CCN(C2CCN(C)CC2)CC1 DRNQLEFHCTVUAW-UHFFFAOYSA-N 0.000 claims 1
• IQUAYBSZCLFKRW-UHFFFAOYSA-N 2-[[1-(4-methoxyphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(2-phenoxyethyl)piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCOC=3C=CC=CC=3)CC2)CCCC1 IQUAYBSZCLFKRW-UHFFFAOYSA-N 0.000 claims 1
• IDOGSSWWDAKNEV-UHFFFAOYSA-N 2-[[1-(4-methoxyphenyl)sulfonylpiperidin-2-yl]methoxy]-1-[4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperazin-1-yl]ethanone Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C=2SC=C(CCC=3C=CC=CC=3)N=2)CCCC1 IDOGSSWWDAKNEV-UHFFFAOYSA-N 0.000 claims 1
• MKOWSTSWVONTAL-UHFFFAOYSA-N 2-[[1-(4-methoxyphenyl)sulfonylpiperidin-2-yl]methoxy]-n-(4-morpholin-4-yl-2,1,3-benzoxadiazol-7-yl)acetamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C(COCC(=O)NC=2C3=NON=C3C(N3CCOCC3)=CC=2)CCCC1 MKOWSTSWVONTAL-UHFFFAOYSA-N 0.000 claims 1
• ILUQDFYZUSHLPC-UHFFFAOYSA-N 2-[[1-(4-methylnaphthalen-1-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=CC=CC=C3C(C)=CC=2)CC1 ILUQDFYZUSHLPC-UHFFFAOYSA-N 0.000 claims 1
• QZCLATZXJHZAIC-UHFFFAOYSA-N 2-[[1-(5-chloro-1,3-dimethylpyrazol-4-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C2=C(N(C)N=C2C)Cl)CC1 QZCLATZXJHZAIC-UHFFFAOYSA-N 0.000 claims 1
• YYOWEGGUPQCWCW-UHFFFAOYSA-N 2-[[1-(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2N3C=CSC3=NC=2Cl)CC1 YYOWEGGUPQCWCW-UHFFFAOYSA-N 0.000 claims 1
• HCVHNQVLPHOJHJ-UHFFFAOYSA-N 2-[[1-[(4-chloro-2,1,3-benzoxadiazol-7-yl)sulfonyl]piperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C3=NON=C3C(Cl)=CC=2)CC1 HCVHNQVLPHOJHJ-UHFFFAOYSA-N 0.000 claims 1
• YPEMDPKOZGLXHY-UHFFFAOYSA-N 2-[[1-[(5-chloro-3-methyl-1-benzothiophen-2-yl)sulfonyl]piperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C2=C(C3=CC(Cl)=CC=C3S2)C)CC1 YPEMDPKOZGLXHY-UHFFFAOYSA-N 0.000 claims 1
• ONQVMPZXUDVJJD-UHFFFAOYSA-N 2-[[1-[2,5-bis(trifluoromethyl)phenyl]sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=C(C=2)C(F)(F)F)C(F)(F)F)CC1 ONQVMPZXUDVJJD-UHFFFAOYSA-N 0.000 claims 1
• ZEIUJVRVPZWDIL-UHFFFAOYSA-N 2-[[1-[2,6-dichloro-4-(trifluoromethyl)phenyl]sulfonylpyrrolidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCC2)S(=O)(=O)C=2C(=CC(=CC=2Cl)C(F)(F)F)Cl)CC1 ZEIUJVRVPZWDIL-UHFFFAOYSA-N 0.000 claims 1
• BCEPZPKQTIPJPA-UHFFFAOYSA-N 2-[[1-[2,6-dichloro-4-(trifluoromethyl)phenyl]sulfonylpyrrolidin-2-yl]methoxy]-1-[4-[3-(dimethylamino)propyl]piperazin-1-yl]ethanone Chemical compound C1CN(CCCN(C)C)CCN1C(=O)COCC1N(S(=O)(=O)C=2C(=CC(=CC=2Cl)C(F)(F)F)Cl)CCC1 BCEPZPKQTIPJPA-UHFFFAOYSA-N 0.000 claims 1
• OIRNMSFCUTUEFX-UHFFFAOYSA-N 2-[[1-[3-(2-methylphenoxy)phenyl]sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound C1CN(C)CCC1N1CCN(C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C=C(OC=3C(=CC=CC=3)C)C=CC=2)CC1 OIRNMSFCUTUEFX-UHFFFAOYSA-N 0.000 claims 1
• JKDYEARPBSWSMT-UHFFFAOYSA-N 2-[[1-[5-(dimethylamino)naphthalen-1-yl]sulfonylpiperidin-2-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone;dihydrochloride Chemical compound Cl.Cl.C1=CC=C2C(N(C)C)=CC=CC2=C1S(=O)(=O)N1CCCCC1COCC(=O)N(CC1)CCN1C1CCN(C)CC1 JKDYEARPBSWSMT-UHFFFAOYSA-N 0.000 claims 1
• HXYKGQZQQRQSQE-UHFFFAOYSA-N 2-[[2-(2,4-dichlorophenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-(4-morpholin-4-ylpiperidin-1-yl)ethanone Chemical compound ClC1=CC(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCOCC2)CC2=CC=CC=C2C1 HXYKGQZQQRQSQE-UHFFFAOYSA-N 0.000 claims 1
• DBAXHXYMKWDLGP-UHFFFAOYSA-N 2-[[2-(2,4-dichlorophenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-(4-piperidin-1-ylpiperidin-1-yl)ethanone Chemical compound ClC1=CC(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)N2CCC(CC2)N2CCCCC2)CC2=CC=CC=C2C1 DBAXHXYMKWDLGP-UHFFFAOYSA-N 0.000 claims 1
• NZLGGJVXBVWQDS-UHFFFAOYSA-N 2-[[2-(2,4-dichlorophenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-n-(3-morpholin-4-ylphenyl)acetamide Chemical compound ClC1=CC(Cl)=CC=C1S(=O)(=O)N1C(COCC(=O)NC=2C=C(C=CC=2)N2CCOCC2)CC2=CC=CC=C2C1 NZLGGJVXBVWQDS-UHFFFAOYSA-N 0.000 claims 1
• SEYJJAFTBNAUJX-UHFFFAOYSA-N 2-[[2-(4-methoxy-2,3,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[2-[(6-methylpyridin-2-yl)methyl]piperidin-1-yl]ethanone Chemical compound CC1=C(C)C(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2C(CCCC2)CC=2N=C(C)C=CC=2)CC2=CC=CC=C2C1 SEYJJAFTBNAUJX-UHFFFAOYSA-N 0.000 claims 1
• SZRPRIZZIWWKCG-UHFFFAOYSA-N 2-[[2-(4-methoxy-2,3,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone Chemical compound CC1=C(C)C(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC2)C2CCN(C)CC2)CC2=CC=CC=C2C1 SZRPRIZZIWWKCG-UHFFFAOYSA-N 0.000 claims 1
• DZKWUAWRBJHCDA-UHFFFAOYSA-N 2-[[2-(4-methoxy-2,3,6-trimethylphenyl)sulfonyl-3,4-dihydro-1h-isoquinolin-3-yl]methoxy]-1-[4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl]ethanone Chemical compound CC1=C(C)C(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CC3CCN(C)CC3)CC2)CC2=CC=CC=C2C1 DZKWUAWRBJHCDA-UHFFFAOYSA-N 0.000 claims 1
• MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 claims 1
• QTJYTEWMROKTFN-UHFFFAOYSA-N 3-[4-[2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]acetyl]piperazin-1-yl]propanenitrile Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCC#N)CC2)CCCC1 QTJYTEWMROKTFN-UHFFFAOYSA-N 0.000 claims 1
• NKUPNJVGUPAMEB-UHFFFAOYSA-N 3-[4-[2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetyl]piperazin-1-yl]propanenitrile Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N2CCN(CCC#N)CC2)CCCC1 NKUPNJVGUPAMEB-UHFFFAOYSA-N 0.000 claims 1
• VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 claims 1
• 125000005872 benzooxazolyl group Chemical group 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• SMBMEJHGRNPMBP-UHFFFAOYSA-N n,n-bis[3-(dimethylamino)propyl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(CCCN(C)C)CCCN(C)C)CCCC1 SMBMEJHGRNPMBP-UHFFFAOYSA-N 0.000 claims 1
• BDKUWCJLDQYWTD-UHFFFAOYSA-N n-(1-benzylpiperidin-4-yl)-n-cyclopropyl-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]acetamide Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)N(C2CC2)C2CCN(CC=3C=CC=CC=3)CC2)CCC1 BDKUWCJLDQYWTD-UHFFFAOYSA-N 0.000 claims 1
• MGYUPQZQTSXQPQ-UHFFFAOYSA-N n-(1-benzylpyrrolidin-3-yl)-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)NC2CN(CC=3C=CC=CC=3)CC2)CCCC1 MGYUPQZQTSXQPQ-UHFFFAOYSA-N 0.000 claims 1
• FCKGPNIMBJVRMS-UHFFFAOYSA-N n-(pyridin-4-ylmethyl)-2-[[1-(2,4,6-trichlorophenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)NCC=2C=CN=CC=2)CCCC1 FCKGPNIMBJVRMS-UHFFFAOYSA-N 0.000 claims 1
• WHCCWBZXDZGGAG-UHFFFAOYSA-N n-[(1-benzylpiperidin-3-yl)methyl]-2-[[1-(2,4,6-trichlorophenyl)sulfonylpyrrolidin-2-yl]methoxy]acetamide Chemical compound ClC1=CC(Cl)=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)NCC2CN(CC=3C=CC=CC=3)CCC2)CCC1 WHCCWBZXDZGGAG-UHFFFAOYSA-N 0.000 claims 1
• JYUCGDXDILWTRR-UHFFFAOYSA-N n-[(1-benzylpiperidin-3-yl)methyl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]acetamide Chemical compound ClC1=CC=CC(Cl)=C1S(=O)(=O)N1C(COCC(=O)NCC2CN(CC=3C=CC=CC=3)CCC2)CCCC1 JYUCGDXDILWTRR-UHFFFAOYSA-N 0.000 claims 1
• XMNPFRBBRTUKCN-UHFFFAOYSA-N n-[(1-benzylpiperidin-3-yl)methyl]-2-[[1-(4-methoxyphenyl)sulfonyl-2,3-dihydroindol-2-yl]methoxy]acetamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C2=CC=CC=C2CC1COCC(=O)NCC1CN(CC=2C=CC=CC=2)CCC1 XMNPFRBBRTUKCN-UHFFFAOYSA-N 0.000 claims 1
• PSBABCIQODUUCI-HMTLIYDFSA-N n-[(3s)-1-benzylpyrrolidin-3-yl]-2-[[1-(2,6-dichlorophenyl)sulfonylpiperidin-2-yl]methoxy]-n-methylacetamide Chemical compound C([C@@H](C1)N(C)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC=CC=2Cl)Cl)CN1CC1=CC=CC=C1 PSBABCIQODUUCI-HMTLIYDFSA-N 0.000 claims 1
• XGRACCOZTUVXNI-PMCHYTPCSA-N n-[(3s)-1-benzylpyrrolidin-3-yl]-2-[[1-(4-methoxy-2,6-dimethylphenyl)sulfonylpiperidin-2-yl]methoxy]-n-methylacetamide Chemical compound CC1=CC(OC)=CC(C)=C1S(=O)(=O)N1C(COCC(=O)N(C)[C@@H]2CN(CC=3C=CC=CC=3)CC2)CCCC1 XGRACCOZTUVXNI-PMCHYTPCSA-N 0.000 claims 1
• YBRLOHGFDKVYNJ-HMTLIYDFSA-N n-[(3s)-1-benzylpyrrolidin-3-yl]-2-[[1-[2,6-dichloro-4-(trifluoromethyl)phenyl]sulfonylpiperidin-2-yl]methoxy]-n-methylacetamide Chemical compound C([C@@H](C1)N(C)C(=O)COCC2N(CCCC2)S(=O)(=O)C=2C(=CC(=CC=2Cl)C(F)(F)F)Cl)CN1CC1=CC=CC=C1 YBRLOHGFDKVYNJ-HMTLIYDFSA-N 0.000 claims 1
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