US20080153843A1 - Substituted sulfonamide compounds - Google Patents

Substituted sulfonamide compounds Download PDF

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US20080153843A1
US20080153843A1 US11/905,381 US90538107A US2008153843A1 US 20080153843 A1 US20080153843 A1 US 20080153843A1 US 90538107 A US90538107 A US 90538107A US 2008153843 A1 US2008153843 A1 US 2008153843A1
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Prior art keywords
methoxy
piperidin
ethanone
dimethylphenylsulfonyl
piperazin
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US11/905,381
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Stefan Oberboersch
Melanie REICH
Stefan SCHUNK
Sabine HEES
Ruth Jostock
Michael Franz-Martin ENGELS
Achim Kless
Thomas Christoph
Klaus Schiene
Tieno Germann
Edward Bijsterveld
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Gruenenthal GmbH
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Gruenenthal GmbH
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Priority to US11/905,381 priority Critical patent/US20080153843A1/en
Publication of US20080153843A1 publication Critical patent/US20080153843A1/en
Assigned to GRUENENTHAL GMBH reassignment GRUENENTHAL GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CHRISTOPH, THOMAS, BIJSTERVELD, EDWARD, KLESS, ACHIM, SCHIENE, KLAUS, ENGELS, MICHAEL FRANZ-MARTIN, GERMANN, TIENO, HEES, SABINE, JOSTOCK, RUTH, OBERBOERSCH, STEFAN, REICH, MELANIE, SCHUNK, STEFAN
Priority to US12/862,271 priority patent/US20100324009A1/en
Priority to US12/862,297 priority patent/US8435978B2/en
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    • C07—ORGANIC CHEMISTRY
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Definitions

  • the present invention relates to substituted sulfonamide derivatives, to a process for their preparation, to medicaments containing these compounds, and to the use of substituted sulfonamide derivatives in the preparation of pharmaceutical compositions and in treatment and/or inhibition of pain and/or various disease states.
  • the bradykinin 1 receptor (B1R) is not expressed or is expressed only weakly in most tissues.
  • B1R the expression of B1R in various cells is inducible. For example, following inflammation reactions there is a rapid and pronounced induction of B1R in neuronal cells but also in various peripheral cells such as fibroblasts, endothelial cells, granulocytes, macrophages and lymphocytes. Accordingly, following inflammation reactions there is a switch from B2R to B1R dominance in the cells that are involved.
  • cytokines interleukin-1 (IL-1) and tumour necrosis factor alpha (TNF ⁇ ) play a substantial part in this B1R up-regulation (Passos et al., J. Immunol. 2004, 172, 1839-1847).
  • B1R-expressing cells are then themselves able to secrete inflammation-promoting cytokines such as IL-6 and IL-8 (Hayashi et al., Eur. Respir. J. 2000, 16, 452-458). This results in the immigration of further inflammatory cells, for example neutrophilic granulocytes (Pesquero et al., PNAS 2000, 97, 8140-8145).
  • bradykinin B1R system can contribute to the chronification of diseases. This is proved by a large number of animal experiments (overviews in Leeb-Lundberg et al., Pharmacol. Rev. 2005, 57, 27-77 and Pesquero et al., Biol. Chem. 2006, 387, 119-126). In humans too, enhanced expression of B1R is found, for example in enterocytes and macrophages in the affected tissue of patients with inflammatory intestinal diseases (Stadnicki et al., Am. J. Physiol. Gastrointest. Liver Physiol.
  • B1R antagonists in acute and, in particular, chronic inflammatory diseases. These include respiratory diseases (Asthma bronchiale, allergies, COPD/chronic-obstructive pulmonary disease, cystic fibrosis, etc.), inflammatory intestinal diseases (ulcerative colitis, CD/Crohn's disease, etc.), neurological diseases (multiple sclerosis, neurodegeneration, etc.), inflammations of the skin (atopic dermatitis, psoriasis, bacterial infections, etc.) and mucosa (Behcet's disease, pelvitis, prostatitis, etc.), rheumatic diseases (rheumatoid arthritis, osteoarthritis, etc.), septic shock and reperfusion syndrome (following heart attack, stroke).
  • respiratory diseases Asthma bronchiale, allergies, COPD/chronic-obstructive pulmonary disease, cystic fibrosis, etc.
  • inflammatory intestinal diseases ulcerative colitis, CD/Crohn's disease, etc
  • bradykinin (receptor) system is also involved in regulating angiogenesis (potential as an angiogenesis inhibitor in cancer and macular degeneration of the eye), and B1R knockout mice are protected against the induction of excess weight as a result of a particularly high-fat diet (Pesquero et al., Biol. Chem. 2006, 387, 119-126). B1R antagonists are therefore suitable also for the treatment of obesity.
  • B1R antagonists are suitable in particular for the treatment of pain, in particular inflammatory pain and neuropathic pain (Calixto et al., Br. J. Pharmacol. 2004, 1-16), in particular diabetic neuropathy (Gabra et al., Biol. Chem. 2006, 387, 127-143). They are also suitable for the treatment of migraine.
  • a particular object of the invention is to provide compounds which a suitable for use in the treatment or inhibition of disorders or diseases which are at least in part related to the B1R-receptor.
  • Another object of the invention is to provide methods of treating or inhibiting disorders or disease states which are at least in part mediated by the B1R-receptor.
  • C 1-3 -alkyl C 1-6 -alkyl
  • C 1-10 -alkyl denote acyclic saturated or unsaturated hydrocarbon radicals which can be branched- or straight-chained as well as unsubstituted or mono- or poly-substituted, having from 1 to 3 carbon atoms or from 1 to 6 carbon atoms or from 1 to 10 carbon atoms, respectively, that is to say C 1-3 -alkanyls, C 2-3 -alkenyls and C 2-3 -alkynyls or C 1-6 -alkanyls, C 2-6 -alkenyls and C 2-6 -alkynyls or C 1-10 -alkanyls, C 2-10 -alkenyls and C 2-10 -alkynyls.
  • Alkenyls have at least one C—C double bond and alkynyls have at least one C—C triple bond.
  • Alkyl is advantageously selected from the group comprising methyl, ethyl, n-propyl, 2-propyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, hexyl, heptanyl, octanyl, nonanyl, decyl, ethylenyl(vinyl), ethynyl, propenyl (—CH 2 CH ⁇ CH 2 , —CH ⁇ CH—CH 3 , —C( ⁇ CH 2 )—CH 3 ), propynyl (—CH—C ⁇ CH, —C ⁇ C—CH 3 ), butenyl, butynyl, pentenyl, pentynyl, hexenyl
  • cycloalkyl or “C 3-8 -cycloalkyl” denotes cyclic hydrocarbons having 3, 4, 5, 6, 7 or 8 carbon atoms, wherein the hydrocarbons can be saturated or unsaturated (but not aromatic), unsubstituted or monosubstituted on one or more ring members.
  • C 3-4 -Cycloalkyl is advantageously selected from the group comprising cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclopentenyl, cyclohexenyl, cycloheptenyl and cyclooctenyl.
  • heterocyclyl denotes mono- or poly-cyclic organic radicals in which at least one ring contains one hetero atom or 2, 3, 4 or 5 identical or different hetero atoms selected from the group consisting of N, O and S.
  • Each heterocyclyl radical can be unsubstituted or monosubstituted on one or more ring members.
  • Saturated and unsaturated heterocyclyl are understood as being in particular monocyclic 5- or 6-membered compounds having at least one hetero atom from the group N, O and S, wherein a further 5- or 6-membered, saturated, unsaturated or aromatic ring, which can likewise contain at least one hetero atom from the group N, O and S, can be fused to those compounds.
  • a saturated or unsaturated heterocyclyl radical is preferably selected from the group comprising pyrrolidinyl, piperidinyl, piperazinyl, pyrazolinyl, morpholinyl, tetrahydropyranyl, dioxanyl, dioxolanyl, indolinyl, isoindolinyl, or
  • heterocyclyl radical can take place via any desired position of the heterocyclyl radical.
  • aryl denotes aromatic hydrocarbons, including phenyls and naphthyls.
  • the aryl radicals can also be fused to further saturated, (partially) unsaturated or aromatic ring systems.
  • Each aryl radical can be unsubstituted or mono- or poly-substituted, wherein the aryl substituents can be identical or different and can be located at any desired and possible position of the aryl.
  • Aryl is advantageously selected from the group comprising phenyl, 1-naphthyl and 2-naphthyl, each of which can be unsubstituted or mono- or poly-substituted.
  • heteroaryl is synonymous with “aromatic heterocyclyl” and denotes a 5-, 6- or 7-membered cyclic aromatic radical containing at least one, optionally also 2, 3, 4 or 5, hetero atom(s), the hetero atoms being identical or different and the heterocycle being unsubstituted or mono- or poly-substituted; in the case of substitution on the heterocycle, the substituents can be identical or different and can be located at any desired and possible position of the heteroaryl.
  • the heterocycle can also be part of a bi- or poly-cyclic system, which can then be more than 7-membered in total, preferably up to 14-membered.
  • Preferred hetero atoms are nitrogen, oxygen and sulfur.
  • heteroaryl radical is selected from the group comprising pyrrolyl, indolyl, furyl(furanyl), benzofuranyl, thienyl(thiophenyl), benzothienyl, benzothiadiazolyl, benzothiazolyl, benzotriazolyl, benzodioxolanyl, benzodioxanyl, phthalazinyl, pyrazolyl, imidazolyl, thiazolyl, oxadiazolyl, isoxazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, pyranyl, indazolyl, purinyl, indolizinyl, quinolinyl, isoquinolinyl, quinazolinyl, quinoxalinyl, carbazolyl, phenazinyl, phenothiazinyl and oxadiazolyl, it
  • aryl or heteroaryl bonded via C 1-3 -alkyl means, for the purposes of the present invention, that C 1-3 -alkyl and aryl or heteroaryl have the meanings defined above and the aryl or heteroaryl radical is bonded to the compound of the general structure I via a C 1-3 -alkyl group. Phenyl, benzyl and phenethyl are particularly advantageous within the scope of this invention.
  • aralkyl denotes an alkyl group substituted by an aryl group.
  • the aralkyl group is preferably selected from the group consisting of benzyl, phenylethyl and phenylpropyl.
  • alkyl and “cycloalkyl”
  • substituted within the scope of this invention is understood as meaning the substitution of a hydrogen radical by F, Cl, Br, I, —CN, NH 2 , NH—C 1-6 -alkyl, NH—C 1-6 -alkyl-OH, C 1-6 -alkyl, N(C 1-6 -alkyl) 2 , N(C 1-6 -alkyl-OH) 2 , NO 2 , SH, S—C 1-6 -alkyl, S-benzyl, O—C 1-6 -alkyl, OH, O—C 1-6 -alkyl-OH, ⁇ O, O-benzyl, C( ⁇ O)C 1-6 -alkyl, CO 2 H, CO 2 —C 1-6 -alkyl or benzyl, polysubstituted radicals being understood as being those radicals that are polysubstituted, for example di- or tri-substit
  • the term “substituted” is understood as meaning the substitution of a hydrogen radical on one or more ring members by F, Cl, Br, I, —CN, NH 2 , NH—C 1-6 -alkyl, NH—C 1-6 -alkyl-OH, C 1-6 -alkyl, N(C 1-6 -alkyl) 2 , N(C 1-6 -alkyl-OH) 2 , pyrrolinyl, piperazinyl, morpholinyl, NO 2 , SH, S—C 1-6 -alkyl, S-benzyl, O—C 1-6 -alkyl, OH, O—C 1-6 -alkyl-OH, ⁇ O, O-benzyl, C( ⁇ O)C 1-6 -alkyl, CO 2 H, CO 2 —C 1-6 alkyl or benzyl.
  • the hydrogen bonded to a N hetero atom can be substituted in
  • aryl and “heteroaryl” or “aromatic heterocyclyl” “mono- or poly-substituted” within the scope of this invention means the substitution of one or more hydrogen atoms of the ring system one or more times, for example two, three or four times, by F, Cl, Br, I, CN, NH 2 , NH—C 1-6 -alkyl, NH—C 1-6 -alkyl-OH, N(C 1-6 -alkyl) 2 , N(C 1-6 -alkyl-OH) 2 , NHaryl, N(aryl) 2 , N(C 1-6 -alkyl)aryl, pyrrolinyl, piperazinyl, morpholinyl, NO 2 , SH, S—C 1-6 -alkyl, OH, O—C 1-6 -alkyl, O—C 1-6 -alkyl-OH, C( ⁇ O)C 1-6 -alkyl, NHSO 2 C
  • a salt formed with a physiologically acceptable acid is understood as meaning salts of the active ingredient in question with inorganic or organic acids that are physiologically acceptable—in particular when used in humans and/or mammals.
  • the hydrochloride is particularly preferred.
  • physiologically acceptable acids include hydrochloric acid, hydrobromic acid, sulfuric acid, methanesulfonic acid, formic acid, acetic acid, oxalic acid, succinic acid, tartaric acid, mandelic acid, fumaric acid, maleic acid, lactic acid, citric acid, glutamic acid, 1,1-dioxo-1,2-dihydro1 ⁇ 6 -benzo[d]isothiazol-3-one (saccharinic acid), monomethylsebacic acid, 5-oxo-proline, hexane-1-sulfonic acid, nicotinic acid, 2-, 3- or 4-aminobenzoic acid, 2,4,6-trimethyl-benzoic acid, ⁇ -liponic acid, acetylglycine, hippuric acid, phosphoric acid and/or aspartic acid.
  • Citric acid and hydrochloric acid are particularly preferred.
  • a basic radical is understood as being a group that is able to react while taking up protons. In particular, it is understood as being a group that contains at least one protonisable nitrogen.
  • a basic radical can in particular represent an optionally fused heterocycle containing at least one nitrogen atom as hetero atom, wherein the heterocycle can optionally be monosubstituted on one or more ring members by C 1-6 -alkyl, O—C 1-6 -alkyl, heterocyclyl, OH, F, Cl, Br, I, —CN, NH 2 , NH(C 1-6 -alkyl), N(C 1-6 -alkyl) 2 , —NH(aryl), —N(C 1-3 -alkyl)(aryl), wherein the aryl radicals bonded to these amino groups can be mono- or poly-substituted by F, Cl, Br, CF 3 , CN, OH or OMe.
  • heterocycles referred to as basic radicals are piperidine, pyrrolidine, azepane, azetidine, azocane, pyrazine, pyridine, imidazole, imidazolidine, 1,2,4-triazole, diazepane, pyrimidine, imidazoline, piperazine, morpholine, quinazoline or quinoxaline.
  • N(C 1-6 -alkyl) 2 NHC 1-6 -alkyl, a N(C 1-6 -alkyl) 2 -substituted aryl radical, in particular phenyl or naphthyl, an aryl or heteroaryl radical, in particular phenyl, naphthyl or pyridinyl, substituted by a 5- to 7-membered heterocyclyl containing at least one N hetero atom, in particular pyrrolidinyl, piperidinyl, 4-methylpiperidinyl or morpholinyl.
  • the bridging chain contains a terminal O or N atom, then that atom can be bonded to the basic radical or to the structure to be bonded to the basic radical.
  • the bridging —(CH 2 ) p — groups or the C 1-3 -alkyl chain can optionally be substituted by ⁇ O, F, Cl, Br, I, —CN, phenyl or pyridinyl.
  • Further examples of basic radicals within the scope of the present invention are C 1-6 -alkylN(C 1-6 -alkyl) 2 or C 1-6 -alkylNH(C 1-6 -alkyl). If the basic radical is fused to the heterocycle formed from R 5 and R 6 , it can represent a 6-membered, saturated, unsaturated or aromatic heterocycle containing at least one N hetero atom, preferably pyridine or thiazole.
  • a basic radical is also understood as being in particular a pyridyl, pyrrolyl, imidazolyl, pyrimidinyl or pyrazinyl radical, each of which can be linked via a C 1-3 -alkyl chain.
  • Further examples of basic radicals are groups having the structure shown below:
  • k 0, 1 or 2
  • L represents H or C 1-6 -alkyl
  • K represents C 1-6 -alkyl
  • M represents C 1-6 -alkyl or N(CH 3 ) 2 .
  • J represents 2-, 3- or 4-pyridyl, phenyl, piperidyl or C 1-6 -alkyl.
  • a non-basic radical is understood as being a group that does not possess basic properties. In particular, it is understood as being a group that does not carry a protonatable nitrogen.
  • Examples of such non-basic radicals are —CN, C 1-6 -alkyl, optionally substituted by methoxy or C 1-3 -alkoxy; or aryl, heteroaryl, 3- to 7-membered heterocycles containing at least one oxygen or sulfur atom, in particular tetrahydropyran or thiophene, each unsubstituted or mono- or poly-substituted.
  • the substituents of the non-basic groups aryl, heteroaryl, 3- to 7-membered heterocycle and C 3-4 -cycloalkyl are preferably selected from F, Cl, Br, I, CN, NO 2 , aralkyl, SH, S—C 1-6 -alkyl, OH, O—C 1-6 -alkyl, O—C 1-6 -alkyl-OH, C( ⁇ O)C 1-6 -alkyl, CO 2 H, CH 2 SO 2 -phenyl, CO 2 —C 1-6 alkyl, OCF 3 , CF 3 ,
  • radicals from the group aryl, heteroaryl, C 3-4 -cycloalkyl each unsubstituted or substituted as described above, which can be linked to the structure of the general formula I via a C 1-3 -alkyl chain, wherein the alkyl chain can be substituted by ⁇ O.
  • C 4-4 -heterocyclyl in connection with R 6 represents a saturated or unsaturated, 4- to 8-membered cyclic radical which can contain 1, 2, 3, 4 or 5 identical or different hetero atoms in the ring system, wherein the hetero atoms are preferably selected from the group N, O and S and wherein both the bond of the heterocyclyl radical to the general basic structure of formula I and the optional substitution with the basic or non-basic groups can be present at any desired ring member.
  • the C 4-4 -heterocyclyl radical is preferably selected from the group consisting of piperidinyl, 2,6-dimethylpiperidinyl, piperazinyl, morpholinyl, pyrrolidinyl, tetrahydropyranyl and tetrahydrofuranyl.
  • a basic heteroaryl radical in connection with R 6 represents a 5- to 10-membered, fused or non-fused hetero-atom-containing radical which contains at least one nitrogen atom as hetero atom and wherein both the bond of the heteroaryl radical to the general basic structure of formula I, or the bond of the heteroaryl radical to the bridging C 1-4 -alkyl group, and the optional substitution can be present at any desired ring member of the heteroaryl radical.
  • the basic heteroaryl is preferably pyrrolyl, pyrazolyl, imidazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, indolyl, indazolyl, benzoimidazolyl and quinolinyl, quinoxalinyl, quinazolinyl.
  • a 5- to 10-membered, aromatic or unsaturated ring fused to an aryl group and optionally containing one or more hetero atoms represents, in connection with R 6 , a ring selected from the group:
  • R 7 represents H or C 1-6 -alkyl.
  • a 5- to 10-membered, saturated or unsaturated ring fused to a C 3-4 -cycloalkyl ring and optionally containing one or more hetero atoms represents, in connection with R 6 , a ring selected from the group: phenyl, pyridinyl, cyclopentane, cyclohexane and cycloheptane.
  • an aromatic, unsaturated or saturated 4- to 10-membered ring fused to the 4- to 8-membered ring formed by R 5 and R 6 represents a ring selected from the group consisting of C 4-10 -cycloalkane, C 4-10 -cycloalkene and C 6-10 -aromatic compounds and 6-membered heteroaromatic compounds.
  • R 1 represents phenyl or benzothiophenyl, especially phenyl, unsubstituted or mono- or poly-substituted by C 1-3 -alkoxy, C 1-6 -alkyl, Cl, F, I, CF 3 , OCF 3 , OH, SH, aryl or heteroaryl, each unsubstituted or mono- or poly-substituted.
  • R 1 in the substituted sulfonamide derivatives according to the invention represents phenyl, naphthyl, indolyl, benzofuranyl, benzothiophenyl, benzoxazolyl, benzoxadiazolyl, pyrrolyl, furanyl, thiophenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, imidazothiazolyl, carbazolyl, dibenzofuranyl and dibenzothiophenyl, preferably phenyl, naphthyl, benzothiophenyl, benzoxadiazolyl, thiophenyl, pyridinyl, imidazothiazolyl and dibenzofuranyl, particularly preferably phenyl, naphthyl and benzothiophenyl, wherein all those radicals can be unsubstituted or mono- or poly-substituted
  • R 1 represents phenyl or naphthyl, especially phenyl, optionally mono- or poly-substituted by methyl, methoxy, CF 3 , Cl, Br and/or F.
  • R 1 represents phenyl substituted in the 4-position by aryl or heteroaryl and in the 2-, 3-, 5- and/or 6-position position by methyl, methoxy, Cl or F, preferably in the 2- and 6-position by methyl.
  • R 1 represents 2,6-dimethyl-4-methoxyphenyl, 2,6-dichloro-4-trifluoromethylphenyl, 2,6-dimethyl-4-bromophenyl, 2,6-dichloro-4-bromophenyl, 2,4,6-trichlorophenyl, 2,4-dichlorophenyl, 2,6-dichlorophenyl, 2,3-dichlorophenyl.
  • R 2a-c , R 3 and R 4 represent H or, with an adjacent radical R 2a-c , R 3 or R 4 , form an aromatic ring, preferably a benzene group, which is optionally mono- or poly-substituted, preferably by methyl, methoxy, CF 3 , Cl, Br and/or F.
  • R 2a-c , R 3 and R 4 represent H.
  • n in the group (CR 2a-c ) n represents 1 or 2, preferably 2.
  • m in the general formula I is 1.
  • the group NR 5 R 6 in the general formula I forms a cyclic group according to formula a1, a2, a3 or a4
  • B represents a basic radical, preferably selected from the group consisting of —NR 8 R 9 , wherein R 8 and R 9 , independently of one another, can represent H or C 1-6 -alkyl, and a radical having the general formula aa1
  • R 10 represents a 4- to 10-membered, aromatic, unsaturated or saturated, mono- or poly-cyclic heterocyclyl group which can contain 1, 2, 3 or 4 N hetero atoms and optionally O and/or S as further hetero atoms, wherein the heterocyclyl group is unsubstituted or monosubstituted on one or more ring members.
  • R 10 can further represent an aryl group substituted by at least one group —NR 11 R 12 or a 5- or 6-membered, monocyclic N-containing aromatic, saturated or unsaturated heterocycle containing 1 or 2 N hetero atoms, wherein R 11 and R 12 , independently of one another, represent H or C 1-6 -alkyl, and the aryl group can optionally carry further substituents.
  • R 10 can further represent a group of the general formula aa2:
  • R 13 can be H or C 1-3 -alkyl
  • R 14 for each chain member d independently, can be H or an optionally substituted aryl or N-heteroaryl group, preferably phenyl, naphthyl or pyridinyl, wherein R 14 can be H only once within the alkyl chain defined by d
  • R 15 is a 5- to 7-membered, saturated or unsaturated heterocyclyl group which is optionally mono-substituted on one or more ring members, contains 1 or 2 N hetero atoms and can contain O or S as further hetero atoms, preferably morpholinyl, piperidinyl or 4-methylpiperazinyl.
  • the cyclic group formed by the group NR 5 R 6 is selected from the group consisting of
  • the basic radical B is selected from the group comprising: —N(C 1-6 -alkyl), preferably —N(CH 3 ) 2 ; a radical having the general formula (aa1), wherein R 10 is selected from the group comprising:
  • radicals can be unsubstituted or monosubstituted on one or more ring members, preferably by C 1-6 -alkyl, especially methyl or ethyl, F, Cl or Br; or R 10 represents
  • the cyclic group formed by the group NR 5 R 6 is
  • the group NR 5 R 6 in the general formula I is a cyclic group according to one of the general formulae b1 and b2:
  • k 1 or 2, preferably 2,
  • l 1, 2 or 3, preferably 2,
  • Z can be NR 17 or O, and R 17 is H or C 1-6 -alkyl, and
  • R 16 represents H or a group of the general formula bb1:
  • R 18 is selected from the group consisting of unsubstituted or mono- or poly-substituted aryl or heteroaryl, wherein the heteroaryl contains at least one N hetero atom, preferably 1, 2 or 3 N hetero atoms, and can contain O and S as further hetero atoms; saturated or unsaturated 5- to 7-membered heterocyclyl, wherein the heterocyclyl contains at least one hetero atom selected from the group N, O and S, preferably 1 or 2 N hetero atoms, and can optionally be monosubstituted or monosubstituted on a plurality of ring members; C 1-6 -alkyl, optionally mono- or poly-substituted; C
  • the cyclic group formed by the group NR 5 R 6 is selected from the group consisting of:
  • R 18 is preferably selected from the group consisting of:
  • those groups can be unsubstituted or mono- or poly-substituted, preferably by C 1-3 -alkyl, especially methyl and/or ethyl; C 1-3 -alkoxy, especially methoxy; F, Cl, Br, I; —CN; CF 3 ; N(C 1-3 -alkyl) 2 , NH(C 1-3 -alkyl), N(C 1-3 -alkyl)(aryl), especially N(C 1-3 -alkyl)(phenyl or phenethyl), wherein phenyl or phenethyl can be mono- or poly-substituted; benzyl or
  • substituents can likewise be mono- or poly-substituted, preferably by F, Cl, Br, —CN, —CF 3 , C 1-3 -alkyl; pyrrolidinyl, piperidinyl, 4-methylpiperidinyl or morpholinyl.
  • R 18 can further represent a heterocyclyl selected from the group consisting of:
  • heterocyclyl groups can be monosubstituted on one or more ring members.
  • R 18 can represent cyclopentyl, cyclohexyl, optionally monosubstituted on one or more ring members, or C 1-3 -alkyl, optionally mono- or poly-substituted.
  • the cyclic group formed by the group NR 5 R 6 is
  • phenyl group can be substituted, preferably monosubstituted by F, Cl or Br, especially F, preferably in the 4-position.
  • R 5 is selected from the group consisting of H and C 1-6 -alkyl, optionally mono- or poly-substituted
  • R 6 is selected from groups of the general formulae c1 and c2 shown below:
  • R 21 is an unsubstituted or substituted aryl group, preferably phenyl or naphthyl, both substituted or unsubstituted, R 22 and R 23 , independently of one another, represent —H or C 1-6 -alkyl, or the group —NR 22 R 23 together represents a 5-, 6- or 7-membered, saturated or unsaturated heterocycle which contains at least one N hetero atom and can optionally be monosubstituted or monosubstituted on a plurality of ring members;
  • R 5 in the group NR 5 R 6 from the general formula I is selected from the group consisting of H and methyl, ethyl, propyl and isopropyl, optionally mono- or poly-substituted.
  • R 5 is a group according to the general formula c1 shown above, wherein:
  • N-heterocycles can be unsubstituted or monosubstituted on one or more ring members, or R 6 represents a group of the general formula c2 shown above, wherein Y represents phenyl, naphthyl, benzooxadiazole, cyclopentyl, cyclohexyl or cycloheptyl, all optionally monosubstituted on one or more ring members, and Z is selected from the group consisting of:
  • R 30 , R 31 and R 40 can represent H, methyl, ethyl, propyl or isopropyl, optionally mono- or poly-substituted, or Z is selected from the group consisting of:
  • R 32 , R 33 and R 34 are selected from H, methyl, ethyl, propyl and isopropyl, optionally mono- or poly-substituted, and the N-heterocycles can optionally be monosubstituted on one or more ring members; or Z is a group NR 24 R 25 wherein R 24 and R 25 , independently of one another, represent methyl, ethyl, propyl or isopropyl, or Z represents a group —C( ⁇ O)—(CH 2 ) d —NR 26 R 27 wherein d is 1 or 2 and NR 26 R 27 together forms a heterocycle selected from
  • R 35 and R 36 can represent methyl, ethyl, propyl or isopropyl, optionally mono- or poly-substituted.
  • R 5 is selected from the group consisting of H, methyl, ethyl, propyl and isopropyl, preferably methyl
  • R 5 in the group NR 5 R 6 from the general formula I is selected from the group consisting of H, C 1-6 -alkyl, optionally mono- or poly-substituted, C 3-8 -cycloalkyl, optionally monosubstituted on one or more ring members.
  • R 6 is selected from groups of the general formula d1
  • R 5 is selected from the group consisting of H and methyl, ethyl, propyl and isopropyl, optionally mono- or poly-substituted
  • R 6 represents a group according to formula d1 shown above wherein J is selected from the group:
  • K is selected from the group consisting of H, phenyl, naphthyl, pyridinyl, all optionally mono- or poly-substituted.
  • R 5 is selected from the group consisting of H, C 1-6 -alkyl, aryl and aralkyl
  • R 41 , R 42 and R 43 are selected from H, methyl, ethyl, propyl and isopropyl, optionally mono- or poly-substituted, and the N-heteroaryls can optionally be mono- or poly-substituted.
  • k 0, 1 or 2
  • L represents H or C 1-6 -alkyl
  • K represents C 1-6 -alkyl
  • M represents C 1-6 -alkyl or N(CH 3 ) 2 ,
  • J represents 2-, 3- or 4-pyridyl, phenyl, piperidyl or C 1-6 -alkyl.
  • k 0, 1 or 2
  • L represents H or C 1-6 -alkyl
  • K represents C 1-6 -alkyl
  • M represents C 1-6 -alkyl or N(CH 3 ) 2 ,
  • J represents 2-, 3- or 4-pyridyl, phenyl, piperidyl or C 1-6 -alkyl
  • R 5 represents H and R 6 represents aryl or C 3-8 -cycloalkyl; or an aryl radical linked via a C 1-3 -alkyl chain, wherein the aryl or C 3-8 -cycloalkyl ring is substituted by at least one basic radical from the group
  • k 0, 1 or 2
  • L represents H or C 1-6 -alkyl
  • K represents C 1-6 -alkyl
  • M represents C 1-6 -alkyl or N(CH 3 ) 2 ,
  • J represents 2-, 3- or 4-pyridyl, phenyl, piperidyl or C 1-6 -alkyl.
  • substituted sulfonamide derivatives of the general formula I wherein R 5 represents H or CH 3 and R 6 represents benzyl or phenethyl substituted by pyrrolidine, piperazine, morpholine or piperidine, wherein these radicals are themselves unsubstituted or monosubstituted by methyl or ethyl and are optionally linked via a C 1-3 -alkyl chain, wherein the benzyl or phenethyl radical is optionally substituted by a further basic radical,
  • R 6 represents
  • R 5 represents H or C 1-5 -alkyl and R 6 represents C 4-8 -heterocyclyl, wherein the heterocyclyl radical is linked to the structure of the general formula I via a carbon atom; or R 6 represents a C 4-8 -heterocyclyl radical linked via a C 1-3 -alkyl chain, wherein the heterocyclyl ring is substituted by a basic radical from the group
  • k 0, 1 or 2
  • L represents H or C 1-6 -alkyl
  • K represents C 1-6 -alkyl
  • M represents C 1-6 -alkyl or N(CH 3 ) 2 .
  • J represents 2-, 3- or 4-pyridyl, phenyl, piperidyl or C 1-6 -alkyl
  • R 5 represents H, methyl or ethyl and R 6 represents piperidine, pyrrolidine, azepane; piperidine, pyrrolidine, azepane, diazepane or piperazine linked via a C 1-3 -alkyl chain; each substituted by phenyl, pyrrolidine, piperazine, morpholine or piperidine linked via a C 1-3 -alkyl chain and unsubstituted or monosubstituted by methyl or ethyl.
  • substituted sulfonamide compounds selected from the group consisting of
  • the compounds according to the invention exhibit an antagonistic action on the human B1R receptor or the B1R receptor of the rat.
  • the substances according to the invention exhibit an antagonistic action both on the human B1R receptor and on the B1R receptor of the rat.
  • the agonistic or antagonistic action of substances can be quantified on the bradykinin receptor 1 (B1R) of the species human and rat with ectopically expressing cell lines (CHO K1 cells) and with the aid of a Ca 2+ -sensitive dye (Fluo-4) using a fluorescent imaging plate reader (FLIPR).
  • B1R bradykinin receptor 1
  • FLIPR fluorescent imaging plate reader
  • the indication in % activation is based on the Ca 2+ signal after addition of Lys-Des-Arg 9 -bradykinin (0.5 nM) or Des-Arg 9 -bradykinin (100 nM).
  • Antagonists result in a suppression of the Ca 2+ influx following administration of the agonist.
  • the % inhibition in comparison with the maximum achievable inhibition is indicated.
  • the substances according to the invention are active, for example, on B1R, which is relevant in connection with various diseases, so that they are suitable as a pharmaceutical active ingredient in a medicament.
  • the invention therefore further provides pharmaceutical compositions or medicaments comprising at least one substituted sulfonamide derivative according to the invention as well as, optionally, suitable additives and/or auxiliary substances and/or, optionally, further active ingredients.
  • the pharmaceutical compositions according to the invention optionally comprise suitable additives and/or auxiliary substances, that is to say carriers, fillers, solvents, diluents, colorings and/or binders, and can be administered as liquid pharmaceutical dosage forms in the form of injection solutions, drops or juices, as semi-solid pharmaceutical dosage forms in the form of granules, tablets, pellets, patches, capsules, plasters/spray-on plasters or aerosols.
  • suitable additives and/or auxiliary substances that is to say carriers, fillers, solvents, diluents, colorings and/or binders, and can be administered as liquid pharmaceutical dosage forms in the form of injection solutions, drops or juices, as semi-solid pharmaceutical dosage forms in the form of granules, tablets, pellets, patches, capsules, plasters/spray-on plasters or aerosols.
  • suitable additives and/or auxiliary substances that is to say carriers, fillers, solvents, diluents, colorings and/or binders
  • Preparations suitable for oral administration are in the form of tablets, dragées, capsules, granules, drops, juices and syrups, and those suitable for parenteral and topical administration and administration by inhalation are solutions, suspensions, readily reconstitutable dry preparations and sprays.
  • Substituted sulfonamide derivatives according to the invention in a depot, in dissolved form or in a plaster, optionally with the addition of agents promoting penetration through the skin, are suitable percutaneous forms of administration.
  • Forms of preparation for oral or percutaneous administration can release the substituted sulfonamide derivatives according to the invention in a delayed manner.
  • the substituted sulfonamide derivatives according to the invention can also be administered in parenteral long-term depot forms, such as, for example, implants or implanted pumps.
  • parenteral long-term depot forms such as, for example, implants or implanted pumps.
  • other further active ingredients known to the person skilled in the art can be added to the medicaments according to the invention.
  • the amount of active ingredient to be administered to the patient varies depending on the weight of the patient, the manner of administration, the indication and the severity of the disease. Usually, from 0.00005 to 50 mg/kg, preferably from 0.01 to 5 mg/kg, of at least one substituted sulfonamide derivative according to the invention are administered.
  • a substituted sulfonamide derivative according to the invention that is present is in the form of a pure diastereoisomer and/or enantiomer, in the form of a racemate or in the form of a non-equimolar or equimolar mixture of the diastereoisomers and/or enantiomers.
  • substituted sulfonamide derivatives according to the invention can be used in the treatment of pain, in particular of acute, visceral, neuropathic or chronic pain.
  • the invention accordingly relates further to the use of a substituted sulfonamide derivative according to the invention in the treatment of pain, in particular of acute, visceral, neuropathic or chronic pain.
  • the invention relates further to the use of a substituted sulfonamide derivative according to the invention in the treatment of diabetes, respiratory diseases, inflammatory intestinal diseases, neurological diseases, inflammations of the skin, rheumatic diseases, septic shock, reperfusion syndrome and obesity, and as an angiogenesis inhibitor.
  • a substituted sulfonamide derivative that is used to be in the form of a pure diastereoisomer and/or enantiomer, in the form of a racemate or in the form of a non-equimolar or equimolar mixture of the diastereoisomers and/or enantiomers.
  • the invention further provides a method of treating, in particular in one of the above-mentioned indications, a non-human mammal or a human requiring treatment for pain, in particular for chronic pain, by administering a therapeutically effective dose of a substituted sulfonamide derivative according to the invention or of a medicament according to the invention.
  • the invention further provides a process for the preparation of the substituted sulfonamide derivatives according to the invention as set out in the following description, examples and claims.
  • the compounds according to the invention can be obtained according to the following synthesis scheme.
  • the racemic (R and S configuration) or enantiomerically pure (R or S configuration) amino acids/acid esters A are converted into an amino alcohol B by means of a reduction, using metal hydrides as reducing agents, such as, for example, LiAlH 4 , BH 3 ⁇ DMS, BH 3 ⁇ THF or NaBH 4 , in an organic solvent, such as THF or diethyl ether, in a temperature range of from ⁇ 20° C. to +100° C., preferably at from 0° C. to +70° C.
  • metal hydrides as, for example, LiAlH 4 , BH 3 ⁇ DMS, BH 3 ⁇ THF or NaBH 4
  • organic solvent such as THF or diethyl ether
  • the amino alcohols B are converted into the sulfonylated amino alcohols G in a sulfonylation using sulfonyl chlorides, bromides or pentafluorophenolates R 1 SO 2 X (X ⁇ Br, Cl or OPFP) in the presence of an organic or inorganic base, for example potassium carbonate, sodium hydrogen carbonate, diisopropylethylamine, triethylamine, pyridine, diethylamine or dimethylaminopyridine, or in the presence of tetra-n-butylammonium chloride and in an organic solvent, for example acetonitrile, dichloromethane or N,N-dimethylformamide, in a temperature range of from 0° C.
  • an organic or inorganic base for example potassium carbonate, sodium hydrogen carbonate, diisopropylethylamine, triethylamine, pyridine, diethylamine or dimethylaminopyridine, or in the presence
  • the racemic (R and S configuration) or enantiomerically pure (R or S configuration) amino acids C are esterified to the amino esters D using water-removing reagents, for example inorganic acids such as H 2 SO 4 or phosphorus oxides, or organic reagents, such as thionyl chloride, in organic solvents, such as THF, diethyl ether, methanol, ethanol or dichloromethane, in a temperature range of from 0° C.
  • water-removing reagents for example inorganic acids such as H 2 SO 4 or phosphorus oxides, or organic reagents, such as thionyl chloride, in organic solvents, such as THF, diethyl ether, methanol, ethanol or dichloromethane, in a temperature range of from 0° C.
  • sulfonylated amino esters E in an ester cleavage using organic acids, such as trifluoroacetic acid, or aqueous inorganic acids, such as hydrochloric acid, or using aqueous inorganic bases, such as lithium hydroxide, potassium hydroxide, sodium hydroxide, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, in organic solvents, such as methanol, dioxane, dichloromethane, THF, diethyl ether or those solvents in the form of mixtures, in a temperature range of from ⁇ 20° C. to +25° C., preferably at room temperature, yield the sulfonylated amino acids F.
  • organic acids such as trifluoroacetic acid
  • aqueous inorganic acids such as hydrochloric acid
  • aqueous inorganic bases such as lithium hydroxide, potassium hydroxide, sodium hydroxide, sodium carbonate, sodium hydrogen carbonate, potassium carbonate
  • organic solvents such as m
  • the sulfonylated amino alcohols G are then converted into the products of the general structure H in an alkylation reaction with halogenated ester derivatives using tetrabutyl-ammonium chloride or bromide or tetrabutylammonium hydrogen sulfate in a phase-transfer reaction using an organic solvent, such as toluene, benzene or xylene, and inorganic base, such as potassium hydroxide, sodium hydroxide, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, or in the presence of an organic or inorganic base
  • conventional inorganic bases are metal alcoholates, such as sodium methanolate, sodium ethanolate, potassium tert-butoxide, lithium or sodium bases, such as lithium diisopropylamide, butyllithium, tert-butyllithium, sodium methoxide, or metal hydrides, such as potassium hydride, lithium hydride, sodium hydride; conventional organic bases are diisopropyleth
  • the carboxylic acids I are converted into the end products of the general formula J in an amide formation using primary or secondary amines, in the presence of water-removing agents, such as sodium or magnesium sulfate, phosphorus oxide or reagents such as, for example, CDI, DCC, TBTU, EDCI or benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP), also in the presence of HOAt or HOBt and of an organic base, for example DIPEA, pyridine or 4-methylmorpholine, in an organic solvent, such as THF, dichloromethane, diethyl ether, dioxane, DMF or acetonitrile, 0° C. to +40° C., preferably at room temperature.
  • water-removing agents such as sodium or magnesium sulfate, phosphorus oxide or reagents such as, for example, CDI, DCC, TBTU, EDCI or benzo
  • the synthesis preferably begins at the stage of the starting materials Ga.
  • the amines or the corresponding hydrochlorides of the general formula J b can be converted into compounds of the general formula J c using aldehydes or ketones in a reductive amination, optionally in the presence of an organic base, such as triethylamine or diisopropylethylamine, and in the presence of a suitable reducing agent, for example sodium triacetoxyborohydride, sodium cyanoborohydride or sodium diacetoxyborohydride, or those or similar reducing agents in the form of polymer-bonded variants, optionally in the presence of acetic acid, in an organic solvent, for example tetrahydrofuran, dichloromethane, 1,2-dichloroethane or those solvents in the form of mixtures, in a temperature range of from ⁇ 0° C. to +25° C.
  • an organic base such as triethylamine or diisopropylethylamine
  • a suitable reducing agent for example sodium triacetoxyborohydride, sodium
  • ketones of the general formula J d can be prepared, as described in method 1 and 2, from commercially available amino alcohols which are used as structural units B and are finally reacted, in the last step, in an amide formation, with piperidin-4-one.
  • the ketones of the general formula J d can be converted into compounds of the general formula J e using amines in a reductive amination, optionally in the presence of an organic base, such as triethylamine or diisopropylethylamine, and in the presence of a suitable reducing agent, for example sodium triacetoxyborohydride, sodium cyanoborohydride or sodium diacetoxy-borohydride, or those or similar reducing agents in the form of polymer-bonded variants, optionally in the presence of acetic acid, in an organic solvent, for example tetrahydrofuran, dichloromethane, 1,2-dichloroethane or those solvents in the form of mixtures, in a temperature range of from ⁇ 0° C. to
  • the commercially available, protected amino alcohols of the general formula J f can be converted into the products of the general structure J g in an alkylation reaction with halogenated ester derivatives using tetrabutylammonium chloride or bromide or tetra-butylammonium hydrogen sulfate in a phase-transfer reaction using an organic solvent, such as toluene, benzene or xylene, and an inorganic base, such as potassium hydroxide, sodium hydroxide, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, or in the presence of an organic or inorganic base
  • conventional inorganic bases are metal alcoholates, such as sodium methanolate, sodium ethanolate, potassium tert-butoxide, lithium or sodium bases, such as lithium diisopropylamide, butyllithium, tert-butyllithium, sodium methoxide, or metal hydrides, such as potassium hydride, lithium hydride, sodium hydride; conventional organic bases are di
  • the carboxylic acids J h can be converted into the products of the general formula J l , in an amide formation using primary or secondary amines, in the presence of water-removing agents, such as sodium or magnesium sulfate, phosphorus oxide or reagents such as, for example, CDI, DCC, TBTU, EDCI or benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP), also in the presence of HOAt or HOBt and an organic base, for example DIPEA, pyridine or 4-methylmorpholine, in an organic solvent, such as THF, dichloromethane, diethyl ether, dioxane, DMF or acetonitrile, at from 0° C.
  • water-removing agents such as sodium or magnesium sulfate, phosphorus oxide or reagents
  • phosphorus oxide or reagents such as, for example, CDI, DCC, TBTU,
  • the compounds J l can be deprotected in the presence of an inorganic or organic acid, such as HCl, trifluoroacetic acid or formic acid, in an organic solvent, such as THF, dichloro-methane, diethyl ether, dioxane, MeOH or chloroform, at from 0° C. to +40° C., preferably at from +25 to +40° C., to form the products of the general formula J j .
  • an inorganic or organic acid such as HCl, trifluoroacetic acid or formic acid
  • organic solvent such as THF, dichloro-methane, diethyl ether, dioxane, MeOH or chloroform
  • the amines J j are converted into the sulfonamides J k in a sulfonylation using sulfonyl chlorides, bromides or pentafluorophenolates R 1 SO 2 X (X ⁇ Br, Cl or OPFP) in the presence of an organic or inorganic base, for example potassium carbonate, sodium hydrogen carbonate, diisopropylethylamine, triethylamine, pyridine, diethylamine, 1,8-diazabicyclo[5.4.0]-undec-7-ene (DBU) and/or dimethylaminopyridine, or in the presence of tetra-n-butylammonium chloride and in an organic solvent, for example acetonitrile, dichloromethane, THF or N,N-dimethylformamide, in a temperature range of from 0° C. to 120° C., preferably at from +25° C. to +70° C.
  • the separation of diastereoisomers and/or enantiomers is carried out according to methods known to the person skilled in the art, for example by recrystallization, chromatography or, in particular, HPLC chromatography or crystallization using an optionally chiral acid or base and with separation of the salts, or chiral HPLC chromatography (Fogassy et al., Optical resolution methods, Org. Biomol. Chem. 2006, 4, 3011-3030).
  • ether means diethyl ether
  • EE means ethyl acetate
  • DCM dichloromethane
  • DMF means dimethylformamide
  • DME dimethoxyethane
  • DMSO means dimethyl sulfoxide
  • THF tetrahydrofuran
  • TBTU O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate
  • CDI 1,1′-carbonyldiimidazole
  • EDCI 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
  • DIPEA N,N-diisopropylamine
  • HOBt 1-hydroxybenzotriazole
  • n-Bu 4 NCl (10 mmol) was added to a solution of the product from step 2 (31 mmol) in toluene (200 ml); the mixture was cooled to 0° C., and first aqueous 35% NaOH (200 ml) and then bromoacetic acid tert-butyl ester (46 mmol) were added dropwise. The reaction mixture was stirred for 3 h and then washed with water until neutral and dried over Na 2 SO 4 , and the organic solvent was removed in vacuo. The crude product was used in the next step without being purified further or was purified by column chromatography. 4.
  • step 3 The product from step 3 (30 mmol) was dissolved in CH 2 Cl 2 (200 ml); TFA (30 ml) was added, and stirring was carried out for 2 h at RT. The solvent was largely removed in vacuo, and the crude product was purified by recrystallization or chromatography.
  • the solution was diluted with a small amount of CH 2 Cl 2 and washed, in succession, with 0.5 M KHSO 4 , saturated aqueous NaHCO 3 solution and saturated aqueous NaCl solution.
  • the organic phase was separated off and dried over Na 2 SO 4 , the solvent was removed in vacuo, and the crude product was purified by means of column chromatography. 3.
  • 4 M NaOH (153 ml, 610 mmol, 4.5 equivalents) was added, with stirring, to a solution of the product from step 2 (136 mmol) in a methanol/dioxane/4 M NaOH mixture in a ratio of 15/4/1 (1020 ml, 203 mmol NaOH, 1.5 equivalents), and stirring was carried out overnight at RT.
  • n-Bu 4 NCl (10 mmol, 2.9 g) was added to a solution of the product from step 4 (31 mmol) in toluene (175 ml), and the mixture was cooled to 0° C.; aqueous 35% NaOH (200 ml) was added first, and then bromoacetic acid tert-butyl ester (48 mmol, 7 ml) was added dropwise.
  • the reaction mixture was stirred for 3 hours and then washed with water until neutral and dried over Na 2 SO 4 , and the organic solvent was removed in vacuo.
  • the crude product was used in the next step without being purified further. 6.
  • the product from step 5 (30 mmol) was dissolved in a mixture of MeOH/dioxane/4 M NaOH in a ratio of 15/4/1 (236 ml, 47 mmol NaOH); further NaOH (4 M, 35 ml, 141 mmol) was added, and stirring was carried out overnight at RT.
  • the solvent was reduced in vacuo, and the residue was diluted with ethyl acetate and washed with 0.5 M KHSO 4 .
  • n-Bu 4 NCl (10 mmol) was added to a solution of the product from step 1 (31 mmol) in toluene (200 ml); the mixture was cooled to 0° C., and first aqueous 35% NaOH (200 ml) and then bromoacetic acid tert-butyl ester (46 mmol) were added dropwise. The reaction mixture was stirred for 3 h and then washed with water until neutral and dried over Na 2 SO 4 , and the organic solvent was removed in vacuo. The crude product was used in the next step without being purified further or was purified by column chromatography.
  • n-Bu 4 NCl (8.8 mmol) was added to a solution of bromoacetic acid tert-butyl ester (40 mmol) in toluene (100 ml).
  • the reaction mixture was cooled to 0° C., and 35% NaOH (150 ml) and then, dropwise, the alcohol (27 mmol) dissolved in toluene (50 ml) were added.
  • the organic phase was separated off and extracted with water (4 ⁇ 150 ml) and with saturated NaCl solution (150 ml).
  • the organic phase was separated off and dried over Na 2 SO 4 ; filtration was carried out, and then the solvent was removed in vacuo.
  • the crude product was purified by column chromatography. 5.
  • the tert-butyl ester (16 mmol) was stirred overnight at RT in 4 M HCl in dioxane (70 ml, 27 mmol). After removal of the solvent, the crude product was purified by column chromatography.
  • n-Bu 4 NCl (9 mmol) was added to a solution of bromoacetic acid tert-butyl ester (42 mmol) in toluene (100 ml).
  • the reaction mixture was cooled to 0° C., and 35% NaOH (150 ml) and then, dropwise, the alcohol (28 mmol) dissolved in toluene (50 ml) were added.
  • the organic phase was separated off and extracted with water (4 ⁇ 150 ml) and with saturated NaCl solution (150 ml).
  • the organic phase was separated off and dried over Na 2 SO 4 ; filtration was carried out, and then the solvent was removed in vacuo.
  • the crude product was purified by column chromatography. 5.
  • the tert-butyl ester (16 mmol) was stirred overnight at RT in 4 M HCl in dioxane (70 ml, 27 mmol). After removal of the solvent, the crude product was purified by column chromatography
  • step 1 A solution of step 1 (1 mmol) dissolved in THF (5 ml) was added dropwise, under a nitrogen atmosphere, to a stirred suspension of LAH (4 mmol) in THF (5 ml).
  • the reaction mixture was stirred at 25° C.; after 16 to 20 h, it was cooled with ice, and aqueous saturated Na 2 SO 4 solution was added dropwise.
  • ethyl acetate 3 ⁇ 10 ml
  • the solvent was largely removed and HCl gas was introduced at 0-5° C.
  • the precipitate was filtered off and washed with ether.
  • the amine hydrochlorides were obtained in the form of products which were used without being worked up further.
  • step 1 A solution of step 1 (1 mmol) dissolved in THF (5 ml) was added dropwise, under a nitrogen atmosphere, to a stirred suspension of LAH (4 mmol) in THF (5 ml).
  • the reaction mixture was heated under reflux for 6 h and cooled with ice, and aqueous saturated Na 2 SO 4 solution was added dropwise. After filtration, the residue was washed with a solvent mixture (ethyl acetate and 10% methanol, 3 ⁇ 10 ml). After removal of the solvent, the amines were obtained, which were used without being worked up further.
  • step 1 (1 mmol) dissolved in THF (5 ml) was added dropwise, under a nitrogen atmosphere, to a stirred suspension of LAH (4 mmol) in THF (5 ml). The reaction mixture was heated under reflux for 6 h and cooled with ice, and aqueous saturated Na 2 SO 4 solution was added dropwise. After filtration, the residue was washed with a solvent mixture (ethyl acetate and 10% methanol, 3 ⁇ 10 ml). The solvent was largely removed in vacuo and the amine was obtained in the form of the hydrochloride by introduction of HCl gas.
  • a reaction mixture of 4-morpholinebenzoic acid (0.5 g) and methanolic HCl solution (6 ml, 4%) was heated under reflux for 6 h, with stirring. After removal of the solvent in vacuo, water (10 ml) was added to the residue and the mixture was neutralized with aqueous saturated NaHCO 3 solution. The solution was extracted with ethyl acetate (3 ⁇ 20 ml). The organic phase was separated off and dried over Na 2 SO 4 . After filtration and removal of the solvent, the product was obtained, which was used in the next step without being worked up further. 2.
  • a reaction mixture of product step 1 (4 g), NH 3 (25 ml) and methanol (20 ml) was heated for 4 d at 120° C.
  • Methanesulfonyl chloride (11 mmol) was added dropwise at 0° C., under nitrogen, to a solution of the alcohol (10 mmol) in CH 2 Cl 2 (50 ml). The reaction mixture was stirred for a further 2 h and then diluted with CH 2 Cl 2 . After extraction with aqueous saturated NaCl solution, drying over Na 2 SO 4 was carried out. After filtration and removal of the solvent, the crude product was obtained in a yield of 80%. 5. A 2 M solution of methylamine in CH 2 Cl 2 (10 ml) was added to a solution of the Ms-protected alcohol (5 mmol) in THF (5 ml), and the reaction solution was heated for 16 h at 100° C.
  • the aqueous phase was removed and discarded. 3 ml of H 2 O and 0.5 ml of CH 2 Cl 2 were added to the organic phase; vortexing was carried out, followed by intensive mixing for 15 min. After centrifugation, the aqueous phase was separated off and discarded. The organic phase was extracted in an analogous manner for a second time with 3 ml of saturated NaCl solution. The organic phase was then removed, introduced into a test glass and dried over a MgSO 4 cartridge. After removal of the solvent by distillation, the crude products were analysed by means of LC-MS and purified by HPLC.
  • N,N′-Carbonyldiimidazole (114 mg, 0.706 mmol) was added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid (250 mg, 0.673 mmol) in dichloromethane (15 ml), and the mixture was stirred for 1 h at room temperature.
  • a solution of 1-(1-methylpiperidin-4-yl)piperazine (123 mg, 0.673 mmol) in dichloromethane (5 ml) was then added, and the reaction mixture was stirred for 15 h at room temperature.
  • the reaction mixture was then extracted with water (20 ml) and saturated sodium chloride solution (20 ml), and the organic phase was dried over magnesium sulfate and concentrated in vacuo.
  • the crude product was purified by flash chromatography using dichloromethane/methanol (97:3 ⁇ 90:10).
  • N,N′-Carbonyldiimidazole (272 mg, 1.696 mmol) was added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid (600 mg, 1.615 mmol) in dichloromethane (15 ml), and the mixture was stirred for 1 h at room temperature.
  • a solution of 1-(1-methylpiperidin-4-yl)piperazine (293 mg, 1.615 mmol) in dichloromethane (5 ml) was then added, and the reaction mixture was stirred for 15 h at room temperature.
  • N,N′-Carbonyldiimidazole (68 mg, 0.424 mmol) was added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid (150 mg, 0.404 mmol) in dichloromethane (4 ml), and the mixture was stirred for 1 h at room temperature.
  • a solution of 3-(piperazin-1-ylmethyl)benzonitrile (81 mg, 0.404 mmol) in dichloromethane (1 ml) was then added, and the reaction mixture was stirred for 15 h at room temperature.
  • N,N′Carbonyldiimidazole (71 mg, 0.441 mmol) was added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetic acid (150 mg, 0.420 mmol) in dichloromethane (7 ml), and the mixture was stirred for 1 h at room temperature.
  • a solution of 3-(piperazin-1-ylmethyl)benzonitrile (84 mg, 0.420 mmol) in dichloromethane (3 ml) was then added, and the reaction mixture was stirred for 15 h at room temperature.
  • N,N′-Carbonyldiimidazole (68 mg, 0.424 mmol) was added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid (150 mg, 0.404 mmol) in dichloromethane (4 ml), and the mixture was stirred for 1 h at room temperature.
  • a solution of 4-(2-(pyrrolidin-1-yl)ethyl)piperidine (73 mg, 0.404 mmol) in dichloromethane (1 ml) was then added, and the reaction mixture was stirred for 15 h at room temperature.
  • N,N′-Carbonyldiimidazole (71 mg, 0.441 mmol) was added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetic acid (150 mg, 0.420 mmol) in dichloromethane (7 ml), and the mixture was stirred for 1 h at room temperature.
  • a solution of 4-(2-(pyrrolidin-1-yl)ethyl)piperidine (76 mg, 0.420 mmol) in dichloromethane (3 ml) was then added, and the reaction mixture was stirred for 15 h at room temperature.
  • N,N′-Carbonyldiimidazole (68 mg, 0.424 mmol) was added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid (150 mg, 0.404 mmol) in dichloromethane (4 ml), and the mixture was stirred for 1 h at room temperature.
  • a solution of 1,2,3,4-tetrahydro-2,6-naphthyridine 54 mg, 0.404 mmol) in dichloromethane (1 ml) was then added, and the reaction mixture was stirred for 15 h at room temperature.
  • the example compounds listed in the following table were prepared from acid structural unit S27 by reaction with the corresponding amines (R 5 R 6 NH) closely following the processes described for Examples 8 and 92-96.
  • the amines used are commercially available, can be prepared by methods known to the person skilled in the art, or were synthesized according to described processes. Instead of the solvent dichloromethane, the solvent N,N-dimethylformamide was used in the synthesis of the following example compounds: Example 113, 143 and 146.
  • ⁇ HCl a corresponding amount of triethylamine was added to the reaction (eq.
  • Example 99 the formation of the hydrochloride was carried out analogously to the process described for Example 97.
  • Examples 106 and 112 were converted into the corresponding hydrochlorides ( ⁇ HCl) by the following general process: The free bases were in each case dissolved in a small amount of methyl ethyl ketone, and 2 M hydrogen chloride solution in diethyl ether (4-5 eq.) was added. Where appropriate, the mixture was cooled to 0° C. and/or diethyl ether was added before the hydrochloride ( ⁇ HCl) was filtered out.
  • the aqueous phase was extracted with diethyl ether (2 ⁇ 30 ml) and the organic phase was in turn washed with saturated sodium chloride solution (20 ml).
  • the organic phase was dried (MgSO 4 ) and concentrated in vacuo.
  • the crude product was purified by column chromatography (silica gel) using ethyl acetate/hexane/methanol/ammonia solution (25% aq.) (100:10:10:1).
  • the amine was prepared analogously to 2-(piperidin-4-yl)-1,2,3,4-tetrahydro-2,6-naphthyridine trihydrochloride from octahydro-1H-pyrido[1,2-a]pyrazine and tert-butyl 4-oxopiperidine-1-carboxylate (steps iv and v).
  • the combined organic phases were extracted with 1 M hydrochloric acid (20 ml) and water (20 ml).
  • the aqueous phases were combined, adjusted to pH 12 with 1 M sodium hydroxide solution and then extracted with dichloromethane (4 ⁇ 20 ml).
  • the organic phase was then washed with saturated sodium chloride solution (20 ml), dried (Na 2 SO 4 ) and concentrated in vacuo.
  • the crude product was then purified by column chromatography (silica gel) using ethyl acetate/hexane (10:1).
  • the amine was prepared analogously to 3-(piperidin-4-yloxy)pyridine hydrochloride from tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate and 3-pyrrolidinol.
  • 7-Chloro-4-(pyrrolidin-1-yl)quinazoline (A) was prepared from 2-amino-4-chlorobenzoic acid analogously to the following procedure, known from the literature, for the preparation of aminoquinazolines: H. Hayashi et al., Bioorg. Med. Chem., 2003, 11, 383. [Review zur Synthese von Chinazolinen: P. J. Guiry et al., Tetrahedron, 2005, 61, 10153.]
  • reaction mixture was then heated for 15 h at 100° C.
  • the reaction mixture was cooled to room temperature, and water (25 ml) and ethyl acetate (25 ml) were added.
  • the aqueous phase was extracted with ethyl acetate (2 ⁇ 25 ml), and the combined organic phases were washed with saturated sodium chloride solution (20 ml).
  • the organic phase was then dried (MgSO 4 ) and concentrated in vacuo.
  • the crude product was purified by column chromatography (silica gel) using ethyl acetate/dichloromethane/ammonia solution (25% aq.) (50:10:0.5) and ethyl acetate/dichloro-methane/methyl tert-butyl ether/ammonia solution (25% aq.) (50:10:10:0.7).
  • Example Compound 137 was prepared from acid structural unit S32 in a yield of 79% by reaction with 1-(1-methylpiperidin-4-yl)piperazine closely following the process described for Examples 8 and 92-96. MS, m/z 535.2 (MH + )
  • Example compound 164 was prepared from the corresponding acid structural unit in a yield of 80% by reaction with 1-(1-methylpiperidin-4-yl)piperazine closely following the process described for Examples 8 and 92-96.
  • the acid structural unit was prepared analogously to the process described under Method 1 for the preparation of acid structural units for parallel synthesis.
  • Example Compound 178 was prepared from the corresponding acid structural unit in a yield of 29% by reaction with 1-(1-methylpiperidin-4-yl)piperazine closely following the process described for Examples 8 and 92-96.
  • the acid structural unit was prepared analogously to the process described under Method 1 for the preparation of acid structural units for parallel synthesis.
  • the hydrochloride precipitation of the free base relating to Example 178 was carried out from a methyl ethyl ketone/diethyl ether solution of the base with addition of 2 M hydrogen chloride solution in diethyl ether.
  • the reaction mixture was heated to room temperature and stirred for 1 h at that temperature.
  • the phases were separated and the aqueous phase was extracted with diethyl ether (2 ⁇ 25 ml).
  • the combined organic phases were washed with saturated sodium chloride solution (20 ml), dried (Na 2 SO 4 ) and concentrated in vacuo.
  • the crude product was purified by column chromatography (silica gel) using hexane/diethyl ether (3:1).
  • Example compounds listed in the following table were prepared from 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-(piperidin-2-ylmethoxy)ethanone trihydrochloride by reaction with the corresponding sulfonyl chlorides (R 1 SO 2 Cl) closely following the process described for Example 108 (step (v)).
  • the progress of the reaction was monitored by thin-layer chromatography; the reaction time was in most cases from 15 h to 3 d.
  • the amounts of the reagents used varied as follows: sulfonyl chloride (from 0.9 to 1.5 eq.), triethylamine (3.5-4.5 eq.).
  • the reactions were in some cases carried out in tetrahydrofuran as an alternative to dichloromethane.
  • the sulfonyl chlorides used are commercially available, can be prepared by methods known to the person skilled in the art, or were synthesized according to described processes.
  • the bases were converted into the corresponding dihydrochlorides (2 ⁇ HCl) according to the following general process:
  • the free bases were in each case dissolved in a small amount of dichloromethane or methyl ethyl ketone, and 2 M hydrogen chloride solution in diethyl ether (4-5 eq.) was added. In some cases, the mixture was cooled to 0° C. and/or diethyl ether was added thereto, before the dihydrochloride was filtered out.
  • Example 102 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone hydrochloride (Example 102) by reaction with the corresponding ketones (R a R b C ⁇ O) closely following the process described for Example 104 (step (ii)).
  • the reactions were monitored by thin-layer chromatography and had reaction times of from 1 to 15 h.
  • the ketones used are commercially available.
  • Example 102 The example compound shown in the following table was prepared from 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone hydrochloride (Example 102) by reaction with the corresponding aldehyde (R a R b C ⁇ O) closely following the process described for Example 117 (step (ii)).
  • the aldehyde used is commercially available.
  • the example compounds listed in the following table were prepared from 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone by reaction with the corresponding aldehydes (R a HC ⁇ O) closely following the process described for Example 197 (step (ii)).
  • the aldehydes used are commercially available, can be prepared by methods known to the person skilled in the art, or were synthesized according to described processes.
  • Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (1.42 g, 3.230 mmol) was then added to the mixture, and stirring was carried out for 3 d at room temperature. The mixture was then concentrated in vacuo, and the residue was taken up in ethyl acetate (30 ml) and saturated sodium hydrogen carbonate solution (20 ml); the aqueous phase was extracted with ethyl acetate (4 ⁇ 10 ml). The combined organic phases were washed with saturated sodium hydrogen carbonate solution (20 ml) and saturated sodium chloride solution (20 ml), dried (MgSO 4 ), and concentrated in vacuo.
  • Example 116 The example compounds listed in the following table were prepared from 1-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperidin-4-one (Example 116) by reaction with the corresponding amines (R c R d NH) closely following the process described for Example 130 (step (ii)).
  • the reactions were monitored by thin-layer chromatography and had reaction times of about 15 h. In some cases, additional sodium triacetoxyborohydride was added subsequently. If the amine was not present in the form of the hydrochloride ( ⁇ HCl), no triethylamine was added.
  • the amines used are commercially available, can be prepared by methods known to the person skilled in the art, or were synthesized by described processes.
  • the reaction mixture was stirred for 21.5 h under a hydrogen atmosphere, filtered over Celite, and washed with dichloromethane/ethanol (9:1).
  • the filtrate was concentrated, coevaporated with toluene and diisopropyl ether, and then dissolved in ethyl acetate, filtered over Celite, washed with ethyl acetate and concentrated again.
  • the residue was dissolved in hot diisopropyl ether, filtered, washed with diisopropyl ether, and concentrated for 7 h in vacuo. Yield: 17.12 g (92%)
  • Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (188 mg, 0.429 mmol) was added to the mixture, and stirring was carried out for 15 h at room temperature. The mixture was then concentrated in vacuo, the residue was taken up in ethyl acetate (20 ml) and saturated sodium hydrogen carbonate solution (10 ml), and the aqueous phase was extracted with ethyl acetate (20 ml). The combined organic phases were dried (Na 2 SO 4 ) and concentrated in vacuo.
  • Example compounds listed in the following table were prepared from the corresponding starting materials closely following the process described for Example 185.
  • the progress of the reaction was monitored in each case by thin-layer chromatography and, on the basis thereof, the reaction times for analogous reactions were adapted accordingly.
  • the reaction temperatures and the equivalent amounts of the reagents used can differ slightly in analogous reactions.
  • the starting materials used are commercially available or were prepared in the manner described.
  • the (S)-amino alcohol used was prepared as follows: Hydrogen bromide-tetrahydrofuran complex (3 eq., 1 M solution in tetrahydrofuran) was added dropwise to a suspension, cooled to 0° C., of the carboxylic acid (1 eq.) in tetrahydrofuran (4 ml/mmol), and the mixture was then stirred for 1 h at room temperature. The reaction mixture was then refluxed for 4 h and stirred for a further 15 h at room temperature. The mixture was cooled to 0° C. and 3 M sodium hydroxide solution was added, and then refluxing was carried out for 6 h.
  • Example compounds listed in the following table were prepared analogously to Example 133 from (S)-(1,2,3,4-tetrahydroisoquinolin-3-yl)methanol, the corresponding sulfonyl chloride (R 1 SO 2 Cl) and the corresponding amine (R 5 R 6 NH).
  • DBU 1,8-diazabicyclo[5.4.0]-undec-7-ene
  • the reaction mixture was heated to room temperature and then stirred for 2 h at that temperature.
  • the phases were separated, and the aqueous phase was extracted with diethyl ether (2 ⁇ 30 ml).
  • the combined organic phases were washed with saturated sodium chloride solution (30 ml), dried (Na 2 SO 4 ) and concentrated in vacuo.
  • the crude product was filtered over silica gel using ethyl acetate and was used in the next step. Yield: 3.2 g (>99%).
  • Example compounds listed in the following table were prepared from the corresponding starting materials closely following the process described for Example 140.
  • the progress of the reaction was in each case monitored by thin-layer chromatography and, on the basis thereof, the reaction times in analogous reactions were adapted accordingly.
  • the reaction temperatures and equivalent amounts of the reagents used can differ in analogous reactions.
  • the amount of triethylamine used in step (v) in each case was adapted according to the stoichiometry of the amine hydrochloride ( ⁇ HCl) used.
  • the starting materials used are commercially available or were prepared in the manner described.
  • Example compounds listed in the following table were prepared from the corresponding starting materials closely following the process described for Example 201.
  • 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid (acid structural unit S27) was synthesized analogously to the process described for Examples 202 and 210 for the preparation of the corresponding carboxylic acid from the corresponding amino alcohol, 4-methoxy-2,6-dimethylbenzene-1-sulfonyl chloride being prepared analogously to the process described for Example 167 (except that 2 eq. of chlorosulfonic acid were used).
  • diisopropylethylamine 2.5 eq.
  • HOBt N-hydroxybenzotriazole
  • EDCI N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride
  • dichloromethane 5 ml/mmol
  • Example compounds listed in the following table were prepared from the corresponding sulfonyl chlorides closely following the process described for Example 202 (step (v)).
  • diisopropylethylamine 2.5 eq.
  • HOBt N-hydroxybenzotriazole
  • EDCI N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride
  • AAV 1 Sulfonylation
  • Acid Structural Units (I) (AAV 1-AAV 3):
  • tert-butyl 2-((1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetate 180 ml of 50% sodium hydroxy solution and 180 ml of tert-butyl bromoacetate were added to a solution of 18 g of (1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methanol, and stirring was carried for 10 minutes. 1.815 g of tetra-n-butylammonium hydrogen sulfate were then added, and stirring was carried out for a further 45 minutes at room temperature.
  • Acid structural unit (Ia) (7.6 mmol) was reacted according to AAV4 with 4-(2-pyrrolidinoethyl)piperidine. The desired product was obtained in a yield of 71%. HPLC-MS, m/z 556.2 (MH + )
  • step A The title compound from step A (18.6 g) was dissolved in THF (190 ml), and the mixture was cooled to ⁇ 78° C. under a protecting gas atmosphere. Then 1.6 M n-BuLi in n-hexane (51 ml) was added sufficiently slowly that the temperature did not rise above ⁇ 70° C. The reaction mixture was stirred for 2 h at ⁇ 70° C., and then MeI (9.7 ml) was added. The reaction mixture was allowed to warm to 0° C. and was stirred for 3 h at that temperature. For working up, sat. NH 4 Cl (80 ml) was added at that temperature, and then the mixture was diluted with EtOAc (500 ml).
  • step B The title compound from step B (0.8 g) was suspended in 4 M HCl (31 ml), and the mixture was heated for 1-2 h at 110° C. It was then cooled to room temperature over a period of 15 h and concentrated completely; the residue obtained after coevaporation twice with DCM (2 ⁇ 30 ml) was dried under a high vacuum. The product so obtained was used in the next step without being purified further. 0.47 g, 70%.
  • step C The title compound from step C (0.46 g) was suspended in toluene (2.2 ml), and SOCl 2 (0.75 ml) and DMF (0.010 ml) were added to the resulting mixture. Heating was then carried out for 1 h at 90° C. until a solution was present. The solution was concentrated completely, and the residue was dried under a high vacuum. The product so obtained was used in the next step without being purified further.
  • step A The title compound from the preparation of 2-methylnaphthalene-1-sulfonyl chloride, step A (20 g) was dissolved in THF (213 ml), and the mixture was cooled to ⁇ 78° C. under a protecting gas atmosphere. Then 1.6 M n-BuLi in n-hexane (55 ml) was added sufficiently slowly that the temperature did not rise above ⁇ 70° C. The reaction mixture was stirred for 2 h at ⁇ 70° C., and then hexachloroethane (21 g) was added. The reaction mixture was allowed to warm to 0° C. and was stirred for 15 h at that temperature. For working up, sat.
  • step A The title compound from step A (3 g) was dissolved in EtOH (15.4 ml), and TFA (0.04 ml) was added. The resulting solution was refluxed for 5 h. After cooling, the mixture was concentrated and the residue was dissolved in DCM (20 ml) and washed with water (10 ml). After drying over MgSO 4 , complete concentration was carried out. The resulting product was used in the next step without being purified further. 2.2 g, 87%.
  • step 4 The title compound from Example 107, step 4 (1.0 g) was placed in DCM (19 ml); cooling to 0° C. was carried out, and Et 3 N (1.8 ml) was added. The title compound from step A (0.5 g) was then added rapidly at that temperature. Stirring was carried out at RT until TLC monitoring indicated that the reaction was complete. For working up, NH 4 Cl solution (10 ml) and water (10 ml) were added, and the organic phase was separated off. The aqueous phase was extracted with DCM (3 ⁇ 15 ml), and the combined organic phases were washed with water (10 ml) and sat. NaCl solution (10 ml).
  • Examples 157, 160, 173-176 and 191 were prepared closely following the process described for Example 179, except that the sulfonyl chlorides and amines mentioned in the following table were used. The preparation of sulfonyl chlorides that are not commercially available was carried out as described above.
  • Methylamine (350 ml of a 40% aqueous solution, 4.06 mol) was added to a solution of 4-(bromomethyl)benzonitrile (51.3 g, 262 mmol) in EtOH (500 ml). After 2 h, the solvent was removed in vacuo and CH 2 Cl 2 (500 ml) and aqueous saturated NaHCO 3 solution (400 ml) were added. The organic phase was separated off and extracted with aqueous saturated NaCl solution (250 ml), over Na 2 SO 4 , and the solvent was removed after filtration in vacuo.
  • Et 3 N 35.96 ml, 256 mmol was added to a solution of the amine (31.17 g, 213 mmol) in CH 2 Cl 2 (150 ml).
  • Benzyl chloroformate 36.37 ml, 256 mmol was then added dropwise at a temperature of 0° C.
  • the reaction mixture was stirred overnight at RT and washed with aqueous 0.1 M HCl (150 ml) and H 2 O (150 ml), dried over Na 2 SO 4 and filtered out, and the solvent was removed in vacuo.
  • the Boc-protected imidazoline (3.03 g, 7.15 mmol) was dissolved in absolute EtOH (60 ml) and hydrogenated under nitrogen for 10 min. with Pd/C (10%, 381 mg, 0.36 mmol) and hydrogen. After stirring for 2 h at RT, filtration over kieselguhr was carried out, followed by washing with EtOH. After removal of the solvent in vacuo, the product was used in the next step without being worked up further.
  • the agonistic or antagonistic action of substances can be determined on the bradykinin receptor 1 (B1R) of the species human and rat using the following assay.
  • B1R bradykinin receptor 1
  • the Ca 2+ influx through the channel is quantified with the aid of a Ca 2+ -sensitive dye (type Fluo-4, Molecular Probes Europe BV, Leiden, Netherlands) using a Fluorescent Imaging Plate Reader (FLIPR, Molecular Devices, Sunnyvale, USA).
  • CHO K1 cells Chinese hamster ovary cells (CHO K1 cells) which have been stably transfected with the human B1R gene (hB1R cells, Euroscreen s.a., Gosselies, Belgium) or with the B1R gene of the rat (rB1R cells, Axxam, Milan, Italy) are used.
  • the cells are plated out on black 96-well plates having a clear base (BD Biosciences, Heidelberg, Germany) in a density of 20,000-25,000 cells/well. The cells are incubated overnight at 37° C.
  • hB1R cells Nutrient Mixture Ham's F12, Gibco Invitrogen GmbH, Düsseldorf, Germany; rB1R cells: D-MEM/F12, Gibco Invitrogen GmbH, Düsseldorf, Germany), with 10 vol. % FBS (fetal bovine serum, Gibco Invitrogen GmbH, Düsseldorf, Germany).
  • FBS fetal bovine serum
  • HBSS buffer Hank's buffered saline solution, Gibco Invitrogen GmbH, Düsseldorf, Germany
  • probenecid Sigma-Aldrich, Taufmün, Germany
  • 10 mM HEPES Sigma-Aldrich, Taufmün, Germany
  • BSA bovine serum albumin
  • gelatin Merck KGaA, Darmstadt, Germany
  • the plates After incubation for a further 20 minutes at room temperature, the plates are inserted into the FLIPR for Ca 2+ measurement.
  • the FLIPR protocol consists of 2 substance additions. Test substances (10 ⁇ M) are first pipetted onto the cells and the Ca 2+ influx is compared with the control (hB1R: Lys-Des-Arg 9 -bradykinin 0.5 nM; rB1R: Des-Arg 9 -bradykinin 100 nM). This gives the activation in %, based on the Ca 2+ signal after addition of Lys-Des-Arg 9 -bradykinin (0.5 nM) or Des-Arg 9 -bradykinin (100 nM).
  • B1R Antagonists Inhibition of the Bradykinin Receptor 1 (B1R)-Mediated Formation of IL-6 in Fibroblasts by Substances According to the Invention as B1R Antagonists
  • the pro-inflammatory cytokines TNF ⁇ lead in various cell types, such as, for example, fibroblasts, to an activation, which brings about inter alia enhanced expression of B1R.
  • a B1R agonist results in the formation of further pro-inflammatory cytokines, such as, for example, IL-6.
  • the chronification of inflammations is thereby promoted.
  • Treatment with a B1R antagonist should lead to inhibition of the B1R agonist-induced IL-6 formation.
  • a B1R antagonist identified in the FLIPR assay was tested in this respect.
  • the human fibroblast cell line IMR-90 (ATCC, CCL-186) was passaged in culture medium (Ham's F12 nutrient mixture, Gibco Invitrogen GmbH, Düsseldorf Germany with 10% FBS, fetal bovine serum, Gibco, Invitrogen GmbH, Düsseldorf Germany; 0.1 mM non-essential amino acids, Gibco, 11140-035, 1 mM sodium pyruvate, Euro Clone, ECM0542D; 1.5 g/l sodium bicarbonate, Euro Clone, ECM0980D) on 80 cm 2 bottles (Nunc; 178905) (ratio: 1:2 to 1:6; medium replaced every 3-4 days) and plated out for experiments on 96-well plates (Greiner bio-one; No. 655180) with 1 ⁇ 10 5 cells per well. The cells are incubated overnight at 37° C. and 5% CO 2 .
  • TNF ⁇ human, recombinant, expressed in E. coli , SIGMA-ALDRICH T6674, 10 ng/ml
  • TNF ⁇ human, recombinant, expressed in E. coli , SIGMA-ALDRICH T6674, 10 ng/ml
  • Lys-Des-Arg 9 -BK human B1R agonist Lys-Des-Arg 9 -bradykinin
  • the final concentrations of Lys-Des-Arg 9 -BK were 1000 nM or 10 nM.
  • Some IMR-90 stimulation batches additionally contained the B1R antagonist of Example 8 in a final concentration of 10 ⁇ M.
  • IL-6 content was determined by means of a commercially available IL-6 Elisa.
  • Elisa kit from: BIOSOURCE; CytoSetsTM, Art. No.: CHC 1264 Material: 96-well microplates: NUNC Brand Systems, Art. No.: 442404A
  • Coating application of primary antibody solution: 50 ⁇ l/well Incubation: covered plate overnight at RT, then tap the plate
  • Blocking application of blocking buffer: 300 ⁇ l/well; incubate plate for 2 hours at RT Washing: 3 ⁇ with 300 ⁇ l of washing solution/well Standard; samples; secondary antibody: application standard, samples per 50 ⁇ l/well immediate addition of the secondary antibody solution: application: 25 ⁇ l/well
  • Incubation shake covered plate for 2 h at RT Washing: 3 ⁇ with 300 ⁇ l of washing solution/well
  • Streptavidin application of streptavidin solution: 100 ⁇ l/well Incubation: covered plate 30 min.
  • Stimulation with TNF ⁇ in combination with Lys-Des-Arg 9 -BK results in an about 10- to 20-fold increase in IL-6 synthesis.
  • This activation of IL-6 formation is inhibited by the B1R antagonist of Example 8 in a dose-dependent manner.
  • the action of the relatively low dose of the agonist Lys-Des-Arg 9 -BK (10 nM) is eliminated almost completely, whereas a relatively high dose of Lys-Des-Arg 9 -BK (1000 nM) is still partially inhibited.
  • the inhibitory action of Example 8 is B1R-specific, because the activating effect of TNF ⁇ alone is not taken into account.
  • the formalin test (Dubuisson, D. and Dennis, S. G., 1977, Pain, 4, 161-174) represents a model for both acute and chronic pain.
  • a biphasic nociceptive reaction is induced in freely mobile test animals; the reaction is detected by observing three behaviour patterns which are clearly distinguishable from one another.
  • the 1st phase reflects a direct stimulation of the peripheral nocisensors with high spinal nociceptive input (acute pain phase); the 2nd phase reflects a spinal and peripheral hypersensitization (chronic pain phase).
  • acute pain phase a direct stimulation of the peripheral nocisensors with high spinal nociceptive input
  • 2nd phase reflects a spinal and peripheral hypersensitization (chronic pain phase).
  • chronic pain component phase 2 has been evaluated.
  • Formalin in a volume of 20 ⁇ l and a concentration of 1% is administered subcutaneously into the dorsal side of the right rear paw of each animal.
  • the specific changes in behavior, such as lifting, shaking or licking of the paw (score 3, Dubuisson & Dennis, 1977), are observed and recorded in the observation period of 21 to 24 minutes following the formalin injection.
  • ED 50 mean effective dose
  • the time of administration before the formalin injection was chosen in dependence on the mode of administration of the compounds according to the invention (intravenous: 5 min.).
  • Type of Example administration ED 50 value [mg/kg] 8 i.v. 12.8 97 i.v. 13.3 98 i.v. 13.6 193 i.v. 2.59

Abstract

Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

Description

    CROSS REFERENCE TO RELATED APPLICATIONS
  • This application claims priority based on co-pending U.S. provisional patent application No. 60/849,438, filed Oct. 5, 2006, the entire disclosure of which is corporated herein by reference. Priority is also claimed based on Federal Republic of Germany patent application no. DE 10 2006 046 743.4, filed Sep. 29, 2006.
    • BACKGROUND OF THE INVENTION
  • The present invention relates to substituted sulfonamide derivatives, to a process for their preparation, to medicaments containing these compounds, and to the use of substituted sulfonamide derivatives in the preparation of pharmaceutical compositions and in treatment and/or inhibition of pain and/or various disease states.
  • Unlike the constitutive expression of the bradykinin 2 receptor (B2R), the bradykinin 1 receptor (B1R) is not expressed or is expressed only weakly in most tissues. However, the expression of B1R in various cells is inducible. For example, following inflammation reactions there is a rapid and pronounced induction of B1R in neuronal cells but also in various peripheral cells such as fibroblasts, endothelial cells, granulocytes, macrophages and lymphocytes. Accordingly, following inflammation reactions there is a switch from B2R to B1R dominance in the cells that are involved. The cytokines interleukin-1 (IL-1) and tumour necrosis factor alpha (TNFα) play a substantial part in this B1R up-regulation (Passos et al., J. Immunol. 2004, 172, 1839-1847). Following activation with specific ligands, B1R-expressing cells are then themselves able to secrete inflammation-promoting cytokines such as IL-6 and IL-8 (Hayashi et al., Eur. Respir. J. 2000, 16, 452-458). This results in the immigration of further inflammatory cells, for example neutrophilic granulocytes (Pesquero et al., PNAS 2000, 97, 8140-8145). By way of these mechanisms, the bradykinin B1R system can contribute to the chronification of diseases. This is proved by a large number of animal experiments (overviews in Leeb-Lundberg et al., Pharmacol. Rev. 2005, 57, 27-77 and Pesquero et al., Biol. Chem. 2006, 387, 119-126). In humans too, enhanced expression of B1R is found, for example in enterocytes and macrophages in the affected tissue of patients with inflammatory intestinal diseases (Stadnicki et al., Am. J. Physiol. Gastrointest. Liver Physiol. 2005, 289, G361-366) or on T-lymphocytes of patients with multiple sclerosis (Prat et al., Neurology, 1999; 53, 2087-2092), or activation of the bradykinin B2R-B1R system is found following infections with Staphylococcus aureus (Bengtson et al., Blood 2006, 108, 2055-2063). Infections with Staphylococcus aureus are responsible for symptoms ranging from superficial skin infections to septic shock.
  • Due to the described pathophysiological relationships there is a great therapeutic potential for the use of B1R antagonists in acute and, in particular, chronic inflammatory diseases. These include respiratory diseases (Asthma bronchiale, allergies, COPD/chronic-obstructive pulmonary disease, cystic fibrosis, etc.), inflammatory intestinal diseases (ulcerative colitis, CD/Crohn's disease, etc.), neurological diseases (multiple sclerosis, neurodegeneration, etc.), inflammations of the skin (atopic dermatitis, psoriasis, bacterial infections, etc.) and mucosa (Behcet's disease, pelvitis, prostatitis, etc.), rheumatic diseases (rheumatoid arthritis, osteoarthritis, etc.), septic shock and reperfusion syndrome (following heart attack, stroke).
  • Moreover, the bradykinin (receptor) system is also involved in regulating angiogenesis (potential as an angiogenesis inhibitor in cancer and macular degeneration of the eye), and B1R knockout mice are protected against the induction of excess weight as a result of a particularly high-fat diet (Pesquero et al., Biol. Chem. 2006, 387, 119-126). B1R antagonists are therefore suitable also for the treatment of obesity.
  • B1R antagonists are suitable in particular for the treatment of pain, in particular inflammatory pain and neuropathic pain (Calixto et al., Br. J. Pharmacol. 2004, 1-16), in particular diabetic neuropathy (Gabra et al., Biol. Chem. 2006, 387, 127-143). They are also suitable for the treatment of migraine.
  • When developing B1R modulators there is, however, the problem that the human and the rat B1R receptor are so very different from one another that many compounds that are good B1R modulators on the human receptor exhibit only poor affinity or no affinity for the rat receptor. This makes animal pharmacological studies considerably more difficult, because many studies are normally carried out on the rat. If there is no activity on the rat receptor, however, neither action nor side-effects can be studied on the rat. This has already resulted in the production of transgenic animals having human B1 receptors for animal pharmacological studies (Hess et al., Biol. Chem. 2006; 387(2): 195-201). However, it is more expensive to work with transgenic animals than with the unchanged animals. Nonetheless, because long-term toxicity studies on the rat form part of the standard studies that are carried out when developing medicaments, but such studies are meaningless where there is an absence of activity on the receptor, there is no important, established instrument for checking safety when developing such compounds. There is therefore a need for novel B1R modulators, B1R modulators that bind both to the rat receptor and to the human receptor offering particular advantages.
    • SUMMARY OF THE INVENTION
  • It is an object of the present invention to provide new pharmaceutically useful compounds.
  • A particular object of the invention is to provide compounds which a suitable for use in the treatment or inhibition of disorders or diseases which are at least in part related to the B1R-receptor.
  • Another object of the invention is to provide methods of treating or inhibiting disorders or disease states which are at least in part mediated by the B1R-receptor.
  • These and other objects are achieved in accordance with the present invention by providing substituted sulfonamide compounds corresponding to the formula I
  • Figure US20080153843A1-20080626-C00001
  • wherein
    • n represents 0, 1, 2 or 3;
    • m represents 1 or 2;
    • R1 represents aryl or heteroaryl;
    • R2a-c, R3 and R4 represent H or, with an adjacent radical R2a-c, R3 or R4, form a five- or six-membered ring which can be saturated or unsaturated and mono- or poly-substituted and which can contain hetero atoms from the group N and O,
    • R5 and R6 together form a 4- to 8-membered ring which can be saturated or unsaturated but not aromatic, wherein the 4- to 8-membered ring can be fused to an aromatic, saturated or unsaturated 4- to 10-membered ring, and the 4- to 8-membered ring and/or the fused 4- to 10-membered ring is substituted by or fused to a basic radical and can be substituted by a further basic radical or radicals from the group C1-6-alkyl, C1-3-alkoxy, C3-8-cycloalkyl, ═O, aralkyl and aryl; or
    • R5 and R6 together form a 4- to 8-membered ring which contains a further hetero atom from the group N and O and can be substituted by a basic or non-basic radical and, in the case where the basic or non-basic substituent is not bonded via the further hetero atom N to the 4- to 8-membered ring, that further hetero atom N can additionally be substituted by a C1-6-alkyl group, an aryl or aralkyl group; or
    • R5 represents H, C1-6-alkyl, C3-8-cycloalkyl, aryl or aralkyl and
    • R6 represents aryl or C3-8-cycloalkyl; or R6 represents an aryl radical linked via a C1-3-alkyl chain, or C3-4-cycloalkyl, wherein the aryl radical and the C3-8-cycloalkyl ring can be fused to a 5- to 10-membered saturated or unsaturated ring optionally containing one or more hetero atoms, and the aryl or C3-8-cycloalkyl ring is substituted by a basic radical or, where appropriate, the substitution with the basic radical takes place on the bridging C1-3-alkyl chain, or
    • R5 represents H, C1-6-alkyl, C3-8-cycloalkyl, aryl or aralkyl and R6 represents C4-8-heterocyclyl; or R6 represents a C4-8-heterocyclyl radical linked via a C1-4-alkyl chain, wherein the heterocyclyl ring can be substituted on one or two ring members by a basic or non-basic radical, or
    • R5 and R6, independently of one another, represent H, aralkyl or a branched or unbranched, optionally mono- or poly-substituted C1-100-alkyl radical which contains from one to three nitrogen atoms, wherein R5 and R6 do not both represent H, or
    • R5 represents H, C1-6-alkyl, C3-8-cycloalkyl, aralkyl or aryl and R6 represents a basic heteroaryl radical which is optionally linked via a C1-4-alkyl group and can be mono- or poly-substituted, wherein the C1-4-alkyl chain can be substituted by a basic radical;
      wherein, unless indicated to the contrary, the above-mentioned radicals C1-6-alkyl, C1-3-alkoxy, aralkyl, aryl and heteroaryl can be unsubstituted or mono- or poly-substituted and the radical C3-8-cycloalkyl can be unsubstituted or monosubstituted on one or more ring members, and wherein the compound may be in the form of the racemate; in the form of the enantiomers, diastereoisomers, mixtures of the enantiomers or diastereoisomers or in the form of an individual enantiomer or diastereoisomer; and/or in the form of a free base or a salt thereof with a physiologically acceptable acid.
  • Within the scope of this invention, the expressions “C1-3-alkyl”, C1-6-alkyl” and “C1-10-alkyl” denote acyclic saturated or unsaturated hydrocarbon radicals which can be branched- or straight-chained as well as unsubstituted or mono- or poly-substituted, having from 1 to 3 carbon atoms or from 1 to 6 carbon atoms or from 1 to 10 carbon atoms, respectively, that is to say C1-3-alkanyls, C2-3-alkenyls and C2-3-alkynyls or C1-6-alkanyls, C2-6-alkenyls and C2-6-alkynyls or C1-10-alkanyls, C2-10-alkenyls and C2-10-alkynyls. Alkenyls have at least one C—C double bond and alkynyls have at least one C—C triple bond. Alkyl is advantageously selected from the group comprising methyl, ethyl, n-propyl, 2-propyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, hexyl, heptanyl, octanyl, nonanyl, decyl, ethylenyl(vinyl), ethynyl, propenyl (—CH2CH═CH2, —CH═CH—CH3, —C(═CH2)—CH3), propynyl (—CH—C≡CH, —C≡C—CH3), butenyl, butynyl, pentenyl, pentynyl, hexenyl and hexynyl. Methyl, ethyl, n-propyl and isopropyl are particularly advantageous.
  • For the purposes of this invention, the term “cycloalkyl” or “C3-8-cycloalkyl” denotes cyclic hydrocarbons having 3, 4, 5, 6, 7 or 8 carbon atoms, wherein the hydrocarbons can be saturated or unsaturated (but not aromatic), unsubstituted or monosubstituted on one or more ring members. C3-4-Cycloalkyl is advantageously selected from the group comprising cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclopentenyl, cyclohexenyl, cycloheptenyl and cyclooctenyl.
  • Within the scope of this invention, the term “heterocyclyl” denotes mono- or poly-cyclic organic radicals in which at least one ring contains one hetero atom or 2, 3, 4 or 5 identical or different hetero atoms selected from the group consisting of N, O and S. Each heterocyclyl radical can be unsubstituted or monosubstituted on one or more ring members. Saturated and unsaturated heterocyclyl are understood as being in particular monocyclic 5- or 6-membered compounds having at least one hetero atom from the group N, O and S, wherein a further 5- or 6-membered, saturated, unsaturated or aromatic ring, which can likewise contain at least one hetero atom from the group N, O and S, can be fused to those compounds. Examples are the benzo- or pyridino-fused analogues of the above-mentioned monocyclic 5- or 6-membered compounds. A saturated or unsaturated heterocyclyl radical is preferably selected from the group comprising pyrrolidinyl, piperidinyl, piperazinyl, pyrazolinyl, morpholinyl, tetrahydropyranyl, dioxanyl, dioxolanyl, indolinyl, isoindolinyl, or
  • Figure US20080153843A1-20080626-C00002
  • Unless indicated to the contrary, the substitution by a heterocyclyl radical can take place via any desired position of the heterocyclyl radical.
  • Within the scope of this invention, the term “aryl” denotes aromatic hydrocarbons, including phenyls and naphthyls. The aryl radicals can also be fused to further saturated, (partially) unsaturated or aromatic ring systems. Each aryl radical can be unsubstituted or mono- or poly-substituted, wherein the aryl substituents can be identical or different and can be located at any desired and possible position of the aryl. Aryl is advantageously selected from the group comprising phenyl, 1-naphthyl and 2-naphthyl, each of which can be unsubstituted or mono- or poly-substituted.
  • The term “heteroaryl” is synonymous with “aromatic heterocyclyl” and denotes a 5-, 6- or 7-membered cyclic aromatic radical containing at least one, optionally also 2, 3, 4 or 5, hetero atom(s), the hetero atoms being identical or different and the heterocycle being unsubstituted or mono- or poly-substituted; in the case of substitution on the heterocycle, the substituents can be identical or different and can be located at any desired and possible position of the heteroaryl. The heterocycle can also be part of a bi- or poly-cyclic system, which can then be more than 7-membered in total, preferably up to 14-membered. Preferred hetero atoms are nitrogen, oxygen and sulfur. It is preferred for the heteroaryl radical to be selected from the group comprising pyrrolyl, indolyl, furyl(furanyl), benzofuranyl, thienyl(thiophenyl), benzothienyl, benzothiadiazolyl, benzothiazolyl, benzotriazolyl, benzodioxolanyl, benzodioxanyl, phthalazinyl, pyrazolyl, imidazolyl, thiazolyl, oxadiazolyl, isoxazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, pyranyl, indazolyl, purinyl, indolizinyl, quinolinyl, isoquinolinyl, quinazolinyl, quinoxalinyl, carbazolyl, phenazinyl, phenothiazinyl and oxadiazolyl, it being possible for bonding to the compounds of the general structure I to take place via any desired and possible ring member of the heteroaryl radical. Pyridyl is particularly preferred.
  • The expression “aryl or heteroaryl bonded via C1-3-alkyl” means, for the purposes of the present invention, that C1-3-alkyl and aryl or heteroaryl have the meanings defined above and the aryl or heteroaryl radical is bonded to the compound of the general structure I via a C1-3-alkyl group. Phenyl, benzyl and phenethyl are particularly advantageous within the scope of this invention.
  • The term “aralkyl” denotes an alkyl group substituted by an aryl group. The aralkyl group is preferably selected from the group consisting of benzyl, phenylethyl and phenylpropyl.
  • In connection with “alkyl” and “cycloalkyl”, the term “substituted” within the scope of this invention is understood as meaning the substitution of a hydrogen radical by F, Cl, Br, I, —CN, NH2, NH—C1-6-alkyl, NH—C1-6-alkyl-OH, C1-6-alkyl, N(C1-6-alkyl)2, N(C1-6-alkyl-OH)2, NO2, SH, S—C1-6-alkyl, S-benzyl, O—C1-6-alkyl, OH, O—C1-6-alkyl-OH, ═O, O-benzyl, C(═O)C1-6-alkyl, CO2H, CO2—C1-6-alkyl or benzyl, polysubstituted radicals being understood as being those radicals that are polysubstituted, for example di- or tri-substituted, either on different atoms or on the same atom, for example trisubstituted on the same carbon atom, as in the case of CF3 or —CH2CF3, or at different positions, as in the case of —CH(OH)—CH═CH—CHCl2. Polysubstitution can be carried out with the same or with different substituents.
  • In connection with “saturated or unsaturated heterocyclyl”, the term “substituted” is understood as meaning the substitution of a hydrogen radical on one or more ring members by F, Cl, Br, I, —CN, NH2, NH—C1-6-alkyl, NH—C1-6-alkyl-OH, C1-6-alkyl, N(C1-6-alkyl)2, N(C1-6-alkyl-OH)2, pyrrolinyl, piperazinyl, morpholinyl, NO2, SH, S—C1-6-alkyl, S-benzyl, O—C1-6-alkyl, OH, O—C1-6-alkyl-OH, ═O, O-benzyl, C(═O)C1-6-alkyl, CO2H, CO2—C1-6 alkyl or benzyl. The hydrogen bonded to a N hetero atom can be substituted in particular by a C1-6-alkyl group.
  • In relation to “aryl” and “heteroaryl” or “aromatic heterocyclyl”, “mono- or poly-substituted” within the scope of this invention means the substitution of one or more hydrogen atoms of the ring system one or more times, for example two, three or four times, by F, Cl, Br, I, CN, NH2, NH—C1-6-alkyl, NH—C1-6-alkyl-OH, N(C1-6-alkyl)2, N(C1-6-alkyl-OH)2, NHaryl, N(aryl)2, N(C1-6-alkyl)aryl, pyrrolinyl, piperazinyl, morpholinyl, NO2, SH, S—C1-6-alkyl, OH, O—C1-6-alkyl, O—C1-6-alkyl-OH, C(═O)C1-6-alkyl, NHSO2C1-6-alkyl, NHCOC1-6-alkyl, CO2H, CH2SO2-phenyl, CO2—C1-6-alkyl, OCF3, CF3,
  • Figure US20080153843A1-20080626-C00003
  • C1-6-alkyl, pyrrolidinyl, imidazolyl, piperidinyl, morpholinyl, benzyloxy, phenoxy, phenyl, pyridyl, alkylaryl, in particular benzyl, thienyl or furyl; on one atom or optionally on different atoms, wherein a substituent can itself optionally be substituted. The polysubstitution is carried out with the same or with different substituents. Preferred substituents for “aryl” or “heteroaryl” are —F, —C1, CF3, CH3 or OCH3.
  • Within the scope of the present invention, the symbol
  • Figure US20080153843A1-20080626-C00004
  • used in the formulae denotes a linking of a corresponding radical to the particular higher-order general structure. If this symbol is arranged in a cyclic or polycyclic, for example aromatic or fused aromatic, group in such a manner that a concrete linkage to a specific position is not identifiable, then this means that a linkage at any position of the cyclic or polycyclic group is to be included.
  • Within the scope of this invention, the expression “a salt formed with a physiologically acceptable acid” is understood as meaning salts of the active ingredient in question with inorganic or organic acids that are physiologically acceptable—in particular when used in humans and/or mammals. The hydrochloride is particularly preferred. Examples of physiologically acceptable acids include hydrochloric acid, hydrobromic acid, sulfuric acid, methanesulfonic acid, formic acid, acetic acid, oxalic acid, succinic acid, tartaric acid, mandelic acid, fumaric acid, maleic acid, lactic acid, citric acid, glutamic acid, 1,1-dioxo-1,2-dihydro1λ6-benzo[d]isothiazol-3-one (saccharinic acid), monomethylsebacic acid, 5-oxo-proline, hexane-1-sulfonic acid, nicotinic acid, 2-, 3- or 4-aminobenzoic acid, 2,4,6-trimethyl-benzoic acid, α-liponic acid, acetylglycine, hippuric acid, phosphoric acid and/or aspartic acid. Citric acid and hydrochloric acid are particularly preferred.
  • Within the scope of this invention, a basic radical is understood as being a group that is able to react while taking up protons. In particular, it is understood as being a group that contains at least one protonisable nitrogen. A basic radical can in particular represent an optionally fused heterocycle containing at least one nitrogen atom as hetero atom, wherein the heterocycle can optionally be monosubstituted on one or more ring members by C1-6-alkyl, O—C1-6-alkyl, heterocyclyl, OH, F, Cl, Br, I, —CN, NH2, NH(C1-6-alkyl), N(C1-6-alkyl)2, —NH(aryl), —N(C1-3-alkyl)(aryl), wherein the aryl radicals bonded to these amino groups can be mono- or poly-substituted by F, Cl, Br, CF3, CN, OH or OMe. Examples of such heterocycles referred to as basic radicals are piperidine, pyrrolidine, azepane, azetidine, azocane, pyrazine, pyridine, imidazole, imidazolidine, 1,2,4-triazole, diazepane, pyrimidine, imidazoline, piperazine, morpholine, quinazoline or quinoxaline. Further basic radicals within the scope of the invention are N(C1-6-alkyl)2, NHC1-6-alkyl, a N(C1-6-alkyl)2-substituted aryl radical, in particular phenyl or naphthyl, an aryl or heteroaryl radical, in particular phenyl, naphthyl or pyridinyl, substituted by a 5- to 7-membered heterocyclyl containing at least one N hetero atom, in particular pyrrolidinyl, piperidinyl, 4-methylpiperidinyl or morpholinyl. All the above-mentioned basic radicals can be linked to the structure of the general formula I via a bridging —OH—, —NH—, —NH[(CH2)p—] group, —N(C1-3-alkyl)[—(CH2)p—] group, —O—[(CH2)p—] group, —O—[—(CH2)p—O—] group, wherein in each case p=1, 2 or 3, or C1-3-alkyl group. If the bridging chain contains a terminal O or N atom, then that atom can be bonded to the basic radical or to the structure to be bonded to the basic radical. The bridging —(CH2)p— groups or the C1-3-alkyl chain can optionally be substituted by ═O, F, Cl, Br, I, —CN, phenyl or pyridinyl. Further examples of basic radicals within the scope of the present invention are C1-6-alkylN(C1-6-alkyl)2 or C1-6-alkylNH(C1-6-alkyl). If the basic radical is fused to the heterocycle formed from R5 and R6, it can represent a 6-membered, saturated, unsaturated or aromatic heterocycle containing at least one N hetero atom, preferably pyridine or thiazole. A basic radical is also understood as being in particular a pyridyl, pyrrolyl, imidazolyl, pyrimidinyl or pyrazinyl radical, each of which can be linked via a C1-3-alkyl chain. Further examples of basic radicals are groups having the structure shown below:
  • Figure US20080153843A1-20080626-C00005
  • wherein
  • k represents 0, 1 or 2,
  • L represents H or C1-6-alkyl,
  • K represents C1-6-alkyl,
  • M represents C1-6-alkyl or N(CH3)2, and
  • J represents 2-, 3- or 4-pyridyl, phenyl, piperidyl or C1-6-alkyl.
  • Further examples and/or preferred forms of basic radicals will become apparent from the following descriptions of the preferred substances according to the invention.
  • A non-basic radical is understood as being a group that does not possess basic properties. In particular, it is understood as being a group that does not carry a protonatable nitrogen. Examples of such non-basic radicals are —CN, C1-6-alkyl, optionally substituted by methoxy or C1-3-alkoxy; or aryl, heteroaryl, 3- to 7-membered heterocycles containing at least one oxygen or sulfur atom, in particular tetrahydropyran or thiophene, each unsubstituted or mono- or poly-substituted. Further examples are unsubstituted C3-4-cycloalkyl or C3-8-cycloalkyl monosubstituted on one or more ring members. The above-mentioned non-basic groups can be linked to the structure of the general formula I via a —O—, —O—[(CH2)q—] or —[(CH2)q—]—O group, —O—[—(CH2)q—O—] group or a bridging C1-3-alkyl group, wherein the —(CH2)q— chain or the alkyl chain can each be substituted by ═O and q=1, 2 or 3. The substituents of the non-basic groups aryl, heteroaryl, 3- to 7-membered heterocycle and C3-4-cycloalkyl are preferably selected from F, Cl, Br, I, CN, NO2, aralkyl, SH, S—C1-6-alkyl, OH, O—C1-6-alkyl, O—C1-6-alkyl-OH, C(═O)C1-6-alkyl, CO2H, CH2SO2-phenyl, CO2—C1-6alkyl, OCF3, CF3,
  • Figure US20080153843A1-20080626-C00006
  • Preference is given to radicals from the group aryl, heteroaryl, C3-4-cycloalkyl, each unsubstituted or substituted as described above, which can be linked to the structure of the general formula I via a C1-3-alkyl chain, wherein the alkyl chain can be substituted by ═O. Preference is further given to C1-6-alkyl, optionally substituted by methoxy; C1-3-alkoxy.
  • In a preferred embodiment of the invention, C4-4-heterocyclyl in connection with R6 represents a saturated or unsaturated, 4- to 8-membered cyclic radical which can contain 1, 2, 3, 4 or 5 identical or different hetero atoms in the ring system, wherein the hetero atoms are preferably selected from the group N, O and S and wherein both the bond of the heterocyclyl radical to the general basic structure of formula I and the optional substitution with the basic or non-basic groups can be present at any desired ring member. The C4-4-heterocyclyl radical is preferably selected from the group consisting of piperidinyl, 2,6-dimethylpiperidinyl, piperazinyl, morpholinyl, pyrrolidinyl, tetrahydropyranyl and tetrahydrofuranyl.
  • In another preferred embodiment of the invention, a basic heteroaryl radical in connection with R6 represents a 5- to 10-membered, fused or non-fused hetero-atom-containing radical which contains at least one nitrogen atom as hetero atom and wherein both the bond of the heteroaryl radical to the general basic structure of formula I, or the bond of the heteroaryl radical to the bridging C1-4-alkyl group, and the optional substitution can be present at any desired ring member of the heteroaryl radical. The basic heteroaryl is preferably pyrrolyl, pyrazolyl, imidazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, indolyl, indazolyl, benzoimidazolyl and quinolinyl, quinoxalinyl, quinazolinyl.
  • In another preferred embodiment of the invention, a 5- to 10-membered, aromatic or unsaturated ring fused to an aryl group and optionally containing one or more hetero atoms represents, in connection with R6, a ring selected from the group:
  • Figure US20080153843A1-20080626-C00007
  • wherein R7 represents H or C1-6-alkyl.
  • In a further preferred embodiment of the invention, a 5- to 10-membered, saturated or unsaturated ring fused to a C3-4-cycloalkyl ring and optionally containing one or more hetero atoms represents, in connection with R6, a ring selected from the group: phenyl, pyridinyl, cyclopentane, cyclohexane and cycloheptane.
  • In a further preferred variant of the present invention, an aromatic, unsaturated or saturated 4- to 10-membered ring fused to the 4- to 8-membered ring formed by R5 and R6 represents a ring selected from the group consisting of C4-10-cycloalkane, C4-10-cycloalkene and C6-10-aromatic compounds and 6-membered heteroaromatic compounds.
  • Preference is given within the scope of this invention to substituted sulfonamide derivatives of the general formula I wherein R1 represents phenyl or benzothiophenyl, especially phenyl, unsubstituted or mono- or poly-substituted by C1-3-alkoxy, C1-6-alkyl, Cl, F, I, CF3, OCF3, OH, SH, aryl or heteroaryl, each unsubstituted or mono- or poly-substituted.
  • In a preferred embodiment of the invention, R1 in the substituted sulfonamide derivatives according to the invention represents phenyl, naphthyl, indolyl, benzofuranyl, benzothiophenyl, benzoxazolyl, benzoxadiazolyl, pyrrolyl, furanyl, thiophenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, imidazothiazolyl, carbazolyl, dibenzofuranyl and dibenzothiophenyl, preferably phenyl, naphthyl, benzothiophenyl, benzoxadiazolyl, thiophenyl, pyridinyl, imidazothiazolyl and dibenzofuranyl, particularly preferably phenyl, naphthyl and benzothiophenyl, wherein all those radicals can be unsubstituted or mono- or poly-substituted, preferably by C1-3-alkoxy, C1-6-alkyl, Br, Cl, F, I, CF3, OCF3, OH, SH, aryl or heteroaryl, each unsubstituted or mono- or poly-substituted.
  • In a further preferred form of the substituted sulfonamide derivatives according to the invention, R1 represents phenyl or naphthyl, especially phenyl, optionally mono- or poly-substituted by methyl, methoxy, CF3, Cl, Br and/or F.
  • Particular preference is further given to substituted sulfonamide derivatives wherein R1 represents phenyl substituted in the 4-position by aryl or heteroaryl and in the 2-, 3-, 5- and/or 6-position position by methyl, methoxy, Cl or F, preferably in the 2- and 6-position by methyl.
  • Most particular preference is given to substituted sulfonamide derivatives wherein R1 represents 2,6-dimethyl-4-methoxyphenyl, 2,6-dichloro-4-trifluoromethylphenyl, 2,6-dimethyl-4-bromophenyl, 2,6-dichloro-4-bromophenyl, 2,4,6-trichlorophenyl, 2,4-dichlorophenyl, 2,6-dichlorophenyl, 2,3-dichlorophenyl.
  • Preference is given also to substituted sulfonamide derivatives of the general formula I wherein n represents 2, R4 and R2b represent H and R3 and R2a together form a six-membered aromatic ring, or wherein n represents 1 and R2a represents H and R4 and R3 together form a six-membered aromatic ring.
  • In a further preferred form of the substituted sulfonamide derivatives according to the invention, R2a-c, R3 and R4 represent H or, with an adjacent radical R2a-c, R3 or R4, form an aromatic ring, preferably a benzene group, which is optionally mono- or poly-substituted, preferably by methyl, methoxy, CF3, Cl, Br and/or F. Particular preference is given to substituted sulfonamide derivatives wherein R2a-c, R3 and R4 represent H.
  • In a further form according to the invention of the substituted sulfonamide derivatives, n in the group (CR2a-c)n represents 1 or 2, preferably 2.
  • In a further preferred form of the substituted sulfonamide derivatives, m in the general formula I is 1.
  • In further preferred embodiments of the present invention:
  • a) the group NR5R6 in the general formula I forms a cyclic group according to formula a1, a2, a3 or a4
  • Figure US20080153843A1-20080626-C00008
  • wherein
    • k=0, 1, 2 or 3, preferably 1 or 2, and
    • w, x, y and z, independently of one another, represent CH or N, with the proviso that not more than two of the groups w, x, y and z simultaneously represent N and that, in the cyclic group according to formula a4, at least one group from w, x, y and z represents N. In formulas a1, a2 and a3, w, x, y and z are preferably all CH or one of w, x, y and z is N and all the others are CH.
  • In formulas a1, a2 and a3, B represents a basic radical, preferably selected from the group consisting of —NR8R9, wherein R8 and R9, independently of one another, can represent H or C1-6-alkyl, and a radical having the general formula aa1
  • Figure US20080153843A1-20080626-C00009
  • In the radical aa1, a, b and c, independently of one another, can be 0 or 1, with the proviso that when b is equal to 0, a and c are not simultaneously 1; and
    the bridging C1-3-alkyl can be monosubstituted by ═O.
    R10 represents a 4- to 10-membered, aromatic, unsaturated or saturated, mono- or poly-cyclic heterocyclyl group which can contain 1, 2, 3 or 4 N hetero atoms and optionally O and/or S as further hetero atoms, wherein the heterocyclyl group is unsubstituted or monosubstituted on one or more ring members. R10 can further represent an aryl group substituted by at least one group —NR11R12 or a 5- or 6-membered, monocyclic N-containing aromatic, saturated or unsaturated heterocycle containing 1 or 2 N hetero atoms, wherein R11 and R12, independently of one another, represent H or C1-6-alkyl, and the aryl group can optionally carry further substituents.
    R10 can further represent a group of the general formula aa2:
  • Figure US20080153843A1-20080626-C00010
  • wherein
    d is 1, 2 or 3,
    R13 can be H or C1-3-alkyl, R14, for each chain member d independently, can be H or an optionally substituted aryl or N-heteroaryl group, preferably phenyl, naphthyl or pyridinyl, wherein R14 can be H only once within the alkyl chain defined by d, and R15 is a 5- to 7-membered, saturated or unsaturated heterocyclyl group which is optionally mono-substituted on one or more ring members, contains 1 or 2 N hetero atoms and can contain O or S as further hetero atoms, preferably morpholinyl, piperidinyl or 4-methylpiperazinyl.
  • In preferred embodiments of the invention, the cyclic group formed by the group NR5R6 is selected from the group consisting of
  • Figure US20080153843A1-20080626-C00011
  • particular preference being given to piperidine substituted in the 4-position by the basic radical B,
    and the basic radical B is selected from the group comprising: —N(C1-6-alkyl), preferably —N(CH3)2; a radical having the general formula (aa1), wherein R10 is selected from the group comprising:
  • Figure US20080153843A1-20080626-C00012
  • wherein those radicals can be unsubstituted or monosubstituted on one or more ring members, preferably by C1-6-alkyl, especially methyl or ethyl, F, Cl or Br;
    or R10 represents
  • Figure US20080153843A1-20080626-C00013
  • which can be unsubstituted or mono- or poly-substituted, preferably by C1-6-alkyl, especially methyl or ethyl, F, Cl, Br, C1-6-alkoxy, especially methoxy, or phenyl; or
    R10 represents phenyl substituted by —N(C1-3-alkyl)2, preferably dimethylamino or diethylamino, or
    phenyl substituted by pyrrolidinyl, imidazolidinyl, dihydroimidazolyl, wherein the linkage can take place at any of the ring members of the phenyl and of the substituent, or
    R10 represents a group of the general formula (aa2), d=1 or 2, R13 represents H or methyl,
    R14 represents phenyl or pyridinyl, and R15 represents morpholinyl or 4-methylpiperazinyl.
  • In further embodiments according to the invention, the cyclic group formed by the group NR5R6 is
  • Figure US20080153843A1-20080626-C00014
  • and the basic radical B is a group having the general formula (aa1) wherein i) a=b=c=0,
    ii) a=c=0 and b=1, iii) a=b=0 and c=1 or iv) a=b=1 and c=0; or the basic radical B is a group having the general formula (aa2) wherein d=1 or 2, preferably 2, and R14 is pyridinyl, preferably 3-pyridinyl, and R15 is morpholinyl.
  • In further preferred embodiments of the invention,
  • b) the group NR5R6 in the general formula I is a cyclic group according to one of the general formulae b1 and b2:
  • Figure US20080153843A1-20080626-C00015
  • wherein
  • k=1 or 2, preferably 2,
  • l=1, 2 or 3, preferably 2,
  • Z can be NR17 or O, and R17 is H or C1-6-alkyl, and
  • R16 represents H or a group of the general formula bb1:
  • Figure US20080153843A1-20080626-C00016
  • wherein
    a and c, independently of one another, are 0 or 1,
    b=0, 1, 2 or 3, with the proviso that when b=0, a and c are not simultaneously 1, and wherein in the alkyl chain defined by b, a CH2 chain member can be replaced by C(═O), R18 is selected from the group consisting of unsubstituted or mono- or poly-substituted aryl or heteroaryl, wherein the heteroaryl contains at least one N hetero atom, preferably 1, 2 or 3 N hetero atoms, and can contain O and S as further hetero atoms; saturated or unsaturated 5- to 7-membered heterocyclyl, wherein the heterocyclyl contains at least one hetero atom selected from the group N, O and S, preferably 1 or 2 N hetero atoms, and can optionally be monosubstituted or monosubstituted on a plurality of ring members; C1-6-alkyl, optionally mono- or poly-substituted; C3-8-cycloalkyl, optionally monosubstituted or monosubstituted on a plurality of ring members; and, apart from the cases where i) c=1 or
    ii) b=c=0 and a=1, R18 can also be selected from the group consisting of —CN and NR19R20, wherein R19 and R20, independently of one another, can be H or C1-6-alkyl but do not simultaneously represent H.
  • In preferred embodiments of the present invention, the cyclic group formed by the group NR5R6 is selected from the group consisting of:
  • Figure US20080153843A1-20080626-C00017
  • wherein R16 represents a group of the general formula bb1 and in the formula bb1 (i) a=0, b=1, 2 or 3 and c=0 or (ii) a=0, b=1, 2 or 3 and c=0. In formula bb1, R18 is preferably selected from the group consisting of:
  • Figure US20080153843A1-20080626-C00018
  • wherein those groups can be unsubstituted or mono- or poly-substituted, preferably by C1-3-alkyl, especially methyl and/or ethyl; C1-3-alkoxy, especially methoxy; F, Cl, Br, I; —CN; CF3; N(C1-3-alkyl)2, NH(C1-3-alkyl), N(C1-3-alkyl)(aryl), especially N(C1-3-alkyl)(phenyl or phenethyl), wherein phenyl or phenethyl can be mono- or poly-substituted; benzyl or
  • Figure US20080153843A1-20080626-C00019
  • and wherein all those substituents can likewise be mono- or poly-substituted, preferably by F, Cl, Br, —CN, —CF3, C1-3-alkyl; pyrrolidinyl, piperidinyl, 4-methylpiperidinyl or morpholinyl.
  • R18 can further represent a heterocyclyl selected from the group consisting of:
  • Figure US20080153843A1-20080626-C00020
  • wherein those heterocyclyl groups can be monosubstituted on one or more ring members.
  • Alternatively, R18 can represent cyclopentyl, cyclohexyl, optionally monosubstituted on one or more ring members, or C1-3-alkyl, optionally mono- or poly-substituted.
  • In further preferred embodiments of the invention, the cyclic group formed by the group NR5R6 is
  • Figure US20080153843A1-20080626-C00021
  • and R16 represents a group according to formula bb1 shown above, wherein a=c=0 and b=0, 1 or 2, and R18 is selected from
  • Figure US20080153843A1-20080626-C00022
  • wherein the phenyl group can be substituted, preferably monosubstituted by F, Cl or Br, especially F, preferably in the 4-position.
  • In further preferred forms of the compounds according to the invention:
  • c) in the group NR5R6 from the general formula I, R5 is selected from the group consisting of H and C1-6-alkyl, optionally mono- or poly-substituted, and R6 is selected from groups of the general formulae c1 and c2 shown below:
  • Figure US20080153843A1-20080626-C00023
  • wherein in formula c1:
    a=0, 1 or 2;
    b=0, 1, 2 or 3;
    R21 is an unsubstituted or substituted aryl group, preferably phenyl or naphthyl, both substituted or unsubstituted,
    R22 and R23, independently of one another, represent —H or C1-6-alkyl, or
    the group —NR22R23 together represents a 5-, 6- or 7-membered, saturated or unsaturated heterocycle which contains at least one N hetero atom and can optionally be monosubstituted or monosubstituted on a plurality of ring members;
  • Figure US20080153843A1-20080626-C00024
  • wherein in formula c2:
    a=0, 1, 2 or 3;
    b=0 or 1, with the proviso that when b=0 also c=0;
    c=0, 1, 2 or 3,
    Y represents aryl or heteroaryl, preferably N-hetero-atom-containing 5- or 6-membered heteroaryl, optionally substituted; C3-4-cycloalkyl, preferably C5-6-cycloalkyl; and
    Z represents a saturated, unsaturated or aromatic, optionally substituted heterocyclyl group which contains at least one N hetero atom and can contain O and/or S as further hetero atoms; or Z represents a group NR24R25, wherein R24 and R25, independently of one another, represent H, C1-6-alkyl or —C(═O)—(CH2)d—NR26R27, wherein d=1 or 2 and R26 and R27, independently of one another, represent H or C1-6-alkyl, or NR26R27 forms a 5-, 6- or 7-membered, preferably saturated heterocycle.
  • In further preferred forms of the substances according to the invention, R5 in the group NR5R6 from the general formula I is selected from the group consisting of H and methyl, ethyl, propyl and isopropyl, optionally mono- or poly-substituted. R5 is a group according to the general formula c1 shown above, wherein:
    • R21 is a phenyl or naphthyl group which can be mono- or poly-substituted and is preferably unsubstituted or substituted by F, Cl, Br, I, CN, C1-3-alkyl, preferably methyl or ethyl;
    • R22 and R23, independently of one another, represent methyl, ethyl or propyl or isopropyl, or the group NR22R23 together represents a N-heterocycle selected from the group consisting of:
  • Figure US20080153843A1-20080626-C00025
  • wherein those N-heterocycles can be unsubstituted or monosubstituted on one or more ring members, or
    R6 represents a group of the general formula c2 shown above, wherein
    Y represents phenyl, naphthyl, benzooxadiazole, cyclopentyl, cyclohexyl or cycloheptyl, all optionally monosubstituted on one or more ring members, and
    Z is selected from the group consisting of:
  • Figure US20080153843A1-20080626-C00026
  • wherein those radicals can be monosubstituted on one or more ring members, and R30, R31 and R40 can represent H, methyl, ethyl, propyl or isopropyl, optionally mono- or poly-substituted, or Z is selected from the group consisting of:
  • Figure US20080153843A1-20080626-C00027
  • wherein R32, R33 and R34 are selected from H, methyl, ethyl, propyl and isopropyl, optionally mono- or poly-substituted, and the N-heterocycles can optionally be monosubstituted on one or more ring members; or
    Z is a group NR24R25 wherein R24 and R25, independently of one another, represent methyl, ethyl, propyl or isopropyl, or Z represents a group —C(═O)—(CH2)d—NR26R27 wherein d is 1 or 2 and NR26R27 together forms a heterocycle selected from
  • Figure US20080153843A1-20080626-C00028
  • wherein the ring members of those radicals can be monosubstituted on one or more ring members, and R35 and R36 can represent methyl, ethyl, propyl or isopropyl, optionally mono- or poly-substituted.
  • In further preferred embodiments of the invention, in the group NR5R6 from the general formula I, R5 is selected from the group consisting of H, methyl, ethyl, propyl and isopropyl, preferably methyl, and R6 represents a group according to the general formula c2 wherein a=1 or 2, b=1 and c=0, Y represents phenyl or cyclohexyl and Z represents pyrrolidinyl or dihydroimidazolyl.
  • In further preferred forms of the compounds according to the invention:
  • d) R5 in the group NR5R6 from the general formula I is selected from the group consisting of H, C1-6-alkyl, optionally mono- or poly-substituted, C3-8-cycloalkyl, optionally monosubstituted on one or more ring members. R6 is selected from groups of the general formula d1
  • Figure US20080153843A1-20080626-C00029
  • wherein in formula d1:
      • a=0, 1, 2, 3 or 4;
      • b=0 or 1, with the proviso that when b=0 also c=0;
      • c=0, 1, 2 or 3;
      • J represents a 4- to 7-membered heterocycle which contains at least one N-hetero atom and is preferably saturated or unsaturated and which can optionally be monosubstituted on one or more ring members, and
      • K represents H or an optionally substituted aryl or heteroaryl group.
  • In further preferred forms of the compounds according to the invention, in the group NR5R6 from the general formula I, R5 is selected from the group consisting of H and methyl, ethyl, propyl and isopropyl, optionally mono- or poly-substituted, and R6 represents a group according to formula d1 shown above wherein J is selected from the group:
  • Figure US20080153843A1-20080626-C00030
  • and K is selected from the group consisting of H, phenyl, naphthyl, pyridinyl, all optionally mono- or poly-substituted.
  • In further preferred forms of the compounds according to the invention:
  • e) in the group NR5R6 from the general formula I, R5 and R6 are selected, independently of one another, from the group consisting of H; C1-6-alkyl; aralkyl; and —(CH2)r—NR28R29 wherein r=from 1 to 6 and wherein R28 and R29 are selected, independently of one another, from the group consisting of H and C1-3-alkyl.
  • In further preferred embodiments according to the invention, in the group NR5R6 from the general formula I:
    • R5 is selected from the group consisting of H, C1-3-alkyl, —(CH2), —NR28R29 wherein r=from 1 to 3 and wherein R28 and R29 can be C1-3-alkyl, and
    • R6 is —(CH2)r—NR28R29 wherein r=from 1 to 3 and wherein R28 and R29 can be C1-3-alkyl, or
    • R6 represents a C1-3-alkyl group substituted by a N(C1-3-alkyl)(aryl) group, wherein the aryl group can be substituted and aryl preferably represents phenyl or naphthyl.
  • In further preferred forms of the compounds according to the invention:
  • f) in the group NR5R6 from the general formula I, R5 is selected from the group consisting of H, C1-6-alkyl, aryl and aralkyl, and R6 is a group of the type —(C1-4-alkyl)s-X wherein s=0 or 1 and wherein the group X is a heteroaryl group which contains at least one N hetero atom and is optionally mono- or poly-substituted, and wherein in the C1-4-alkyl group a hydrogen atom can be replaced by a 5- or 6-membered, saturated heterocyclyl group which contains at least one N hetero atom and can contain, in addition to N, also O and/or S as hetero atom.
  • In further preferred embodiments according to the invention, in the group NR5R6 from the general formula I:
    • R5 represents H, methyl, ethyl, propyl, isopropyl, phenyl or benzyl; and
    • R6 represents a group of the (C1-3-alkyl)r-X type, wherein s=0 or 1 and wherein the C1-3-alkyl group can be substituted by a pyrrolidinyl, piperidinyl, piperazinyl or morpholinyl group and the radical X is selected from the group consisting of:
  • Figure US20080153843A1-20080626-C00031
  • wherein R41, R42 and R43 are selected from H, methyl, ethyl, propyl and isopropyl, optionally mono- or poly-substituted, and the N-heteroaryls can optionally be mono- or poly-substituted.
  • In further preferred embodiments according to the invention, in general formula I:
    • n represents 0, 1, 2 or 3;
    • m represents 1 or 2;
    • R1 represents aryl or heteroaryl, unsubstituted or mono- or poly-substituted;
    • R2a-c, R3 and R4 represent H or, with an adjacent radical R2a-c, R3 or R4, form a five- or six-membered ring which can be saturated or unsaturated and mono- or poly-substituted and which can contain hetero atoms from the group N and O,
    • R5 and R6 together form a 4- to 8-membered ring which can be saturated or unsaturated but not aromatic, is substituted by or fused to a basic radical and can be substituted by a further basic radical or radicals from the group C1-8-alkyl, C1-3-alkoxy, C3-8-cycloalkyl and optionally substituted phenyl; or
    • R5 and R6 together form a 4- to 8-membered ring which contains a further hetero atom from the group N and O and can be substituted by a basic or non-basic radical, or
    • R5 represents H or C1-5-alkyl and R6 represents aryl or C3-8-cycloalkyl; or an aryl radical linked via a C1-3-alkyl chain, wherein the aryl or C3-8-cycloalkyl ring is substituted by a basic radical or, where appropriate, the basic substitution takes place on the bridging C1-3-alkyl chain, or
    • R5 represents H or C1-5-alkyl and R6 represents C4-8-heterocyclyl; or a C4-8-heterocyclyl radical linked via a C1-3-alkyl chain, wherein the heterocyclyl ring is substituted by a basic radical or a non-basic radical, or
    • R5 and R6, independently of one another, represent H or a branched or unbranched C1-10-alkyl radical which contains from one to three nitrogen atoms, wherein R5 and R6 do not both represent H,
      in the form of the racemate; in the form of the enantiomers, diastereoisomers, mixtures of the enantiomers or diastereoisomers or in the form of an individual enantiomer or diastereoisomer; in the form of bases and/or salts of physiologically acceptable acids, wherein preferably
      a substituted aryl or heteroaryl radical is substituted by F, Cl, Br, I, CN, NH2, NH—C1-6-alkyl, NH—C1-6-alkyl-OH, N(C1-6-alkyl)2, N(C1-6-alkyl-OH)2, NO2, SH, S—C1-6-alkyl, OH, O—C1-6-alkyl, O—C1-6-alkyl-OH, C(═O)C1-6-alkyl, CO2H, CH2SO2-phenyl, CO2—C1-6-alkyl, OCF3, CF3,
  • Figure US20080153843A1-20080626-C00032
  • C1-6-alkyl, phenoxy, phenyl, pyridyl, thienyl or furyl, a substituted cycloalkyl radical or alkyl radical is substituted by F, Cl, Br, I, —CN, NH2, NH—C1-6-alkyl, NH—C1-6-alkyl-OH, C1-6-alkyl, N(C1-6-alkyl)2, N(C1-6-alkyl-OH)2, NO2, SH, S—C1-6-alkyl, S-benzyl, O—C1-6-alkyl, OH, O—C1-6-alkyl-OH, ═O, O-benzyl, C(═O)C1-6-alkyl, CO2H, CO2—C1-6-alkyl or benzyl,
    a basic radical preferably denotes piperidine, pyrrolidine, azepane, azetidine, azocane, pyridine, imidazole, imidazolidine, 1,2,4-triazole, diazepane, pyrimidine, imidazoline, piperazine, N(C1-6-alkyl)2, NHC1-6-alkyl, an aryl radical substituted by N(C1-6-alkyl)2; wherein these radicals can all be linked to the structure of the general formula I via a C1-3-alkyl group, the C1-3-alkyl chain is optionally substituted by ═O and the remaining radicals can themselves be substituted by C1-6-alkyl; C1-6-alkylN(C1-6-alkyl)2 or C1-6-alkylNH(C1-6-alkyl), and
    a non-basic radical preferably denotes aryl, heteroaryl, each unsubstituted or mono- or poly-substituted by F, Cl, Br, I, CN, NO2, SH, S—C1-6-alkyl, OH, O—C1-6-alkyl, O—C1-6-alkyl-OH, C(═O)C1-6-alkyl, CO2H, CH2SO2-phenyl, CO2—C1-6-alkyl, OCF3, CF3,
  • Figure US20080153843A1-20080626-C00033
  • which can be linked to the structure of the general formula I via a C1-3-alkyl chain, wherein the alkyl chain can be substituted by ═O; C1-6-alkyl optionally substituted by methoxy or C1-3-alkoxy; or C3-8-cycloalkyl.
  • Within the scope of this invention, preference is further given to substituted sulfonamide derivatives of the general formula I wherein R5 and R6 together form a 4- to 8-membered ring which can be saturated or unsaturated but not aromatic and is substituted by a basic radical selected from the group consisting of
  • Figure US20080153843A1-20080626-C00034
  • wherein
  • k represents 0, 1 or 2,
  • L represents H or C1-6-alkyl,
  • K represents C1-6-alkyl,
  • M represents C1-6-alkyl or N(CH3)2,
  • J represents 2-, 3- or 4-pyridyl, phenyl, piperidyl or C1-6-alkyl.
  • Particular preference is given to substituted sulfonamide derivatives wherein the group
  • Figure US20080153843A1-20080626-C00035
  • represents piperidine, pyrrolidine or azepane, substituted by optionally C1-3-alkyl-linked piperidine, pyrrolidine, azepane, piperazine or diazepane, unsubstituted or monosubstituted by methyl or ethyl, with the proviso that the linkage takes place between two carbon atoms or between a carbon atom and a nitrogen atom but not between two nitrogen atoms;
    in particular a radical selected from the group consisting of:
  • Figure US20080153843A1-20080626-C00036
  • Preference is given also to substituted sulfonamide derivatives of the general formula I wherein R5 and R6 together form a 4- to 8-membered ring which contains a further hetero atom from the group N and O and can be substituted by a basic radical from the group
  • Figure US20080153843A1-20080626-C00037
  • wherein
  • k represents 0, 1 or 2,
  • L represents H or C1-6-alkyl,
  • K represents C1-6-alkyl,
  • M represents C1-6-alkyl or N(CH3)2,
  • J represents 2-, 3- or 4-pyridyl, phenyl, piperidyl or C1-6-alkyl,
  • or by a non-basic radical from the group aryl, heteroaryl, each unsubstituted or mono- or poly-substituted by F, Cl, Br, I, CF3, OCH3, C1-6-alkyl, C3-4-cycloalkyl, unsubstituted or monosubstituted by F, Cl, Br, I, CF3, OCH3, C1-6-alkyl; which can be linked to the structure of the general formula I via a C1-3-alkyl chain, wherein the alkyl chain can be substituted by ═O; C1-6-alkyl or C1-3-alkoxy.
  • Particular preference is given to substituted sulfonamide derivatives wherein the group
  • Figure US20080153843A1-20080626-C00038
  • represents piperazine or diazepane, substituted by optionally C1-3-alkyl-linked phenyl, unsubstituted or mono- or poly-substituted by
  • Figure US20080153843A1-20080626-C00039
  • methyl, methoxy, F, Cl, Br, CF3 or CN; (CH2)2OCH3; substituted by cyclohexyl or cyclopentyl optionally bonded via C1-3-alkyl; pyrrolidine, piperazine, piperidine, unsubstituted or monosubstituted by methyl or ethyl, each linked via a C1-3-alkyl group; or pyrrolidine, piperazine, piperidine, unsubstituted or monosubstituted by methyl or ethyl, with the proviso that the linkage takes place between two carbon atoms or between a carbon atom and a nitrogen atom but not between two nitrogen atoms; or by (CH2)aN(CH3)2 wherein a=2, 3;
    in particular a radical selected from the group consisting of
  • Figure US20080153843A1-20080626-C00040
    Figure US20080153843A1-20080626-C00041
  • Preference is additionally given to substituted sulfonamide derivatives of the general formula I wherein R5 represents H and R6 represents aryl or C3-8-cycloalkyl; or an aryl radical linked via a C1-3-alkyl chain, wherein the aryl or C3-8-cycloalkyl ring is substituted by at least one basic radical from the group
  • Figure US20080153843A1-20080626-C00042
  • wherein
  • k represents 0, 1 or 2,
  • L represents H or C1-6-alkyl,
  • K represents C1-6-alkyl,
  • M represents C1-6-alkyl or N(CH3)2,
  • J represents 2-, 3- or 4-pyridyl, phenyl, piperidyl or C1-6-alkyl.
  • Particular preference is given to substituted sulfonamide derivatives of the general formula I wherein R5 represents H or CH3 and R6 represents benzyl or phenethyl substituted by pyrrolidine, piperazine, morpholine or piperidine, wherein these radicals are themselves unsubstituted or monosubstituted by methyl or ethyl and are optionally linked via a C1-3-alkyl chain, wherein the benzyl or phenethyl radical is optionally substituted by a further basic radical,
  • in particular R6 represents
  • Figure US20080153843A1-20080626-C00043
    Figure US20080153843A1-20080626-C00044
  • Preference is given also to substituted sulfonamide derivatives wherein R5 represents H or C1-5-alkyl and R6 represents C4-8-heterocyclyl, wherein the heterocyclyl radical is linked to the structure of the general formula I via a carbon atom; or R6 represents a C4-8-heterocyclyl radical linked via a C1-3-alkyl chain, wherein the heterocyclyl ring is substituted by a basic radical from the group
  • Figure US20080153843A1-20080626-C00045
  • wherein
  • k represents 0, 1 or 2,
  • L represents H or C1-6-alkyl,
  • K represents C1-6-alkyl,
  • M represents C1-6-alkyl or N(CH3)2, and
  • J represents 2-, 3- or 4-pyridyl, phenyl, piperidyl or C1-6-alkyl,
  • or by a non-basic radical from the group aryl, heteroaryl, each unsubstituted or mono- or poly-substituted by F, Cl, Br, I, CF3, OCH3, C1-6-alkyl, C3-8-cycloalkyl, unsubstituted or mono- or poly-substituted by F, Cl, Br, I, CF3, OCH3, C1-6-alkyl; which can be linked to the structure of the general formula I via a C1-3-alkyl chain, wherein the alkyl chain can be substituted by ═O; C1-6-alkyl or C1-3-alkoxy.
  • Particular preference is given to substituted sulfonamide derivatives wherein R5 represents H, methyl or ethyl and R6 represents piperidine, pyrrolidine, azepane; piperidine, pyrrolidine, azepane, diazepane or piperazine linked via a C1-3-alkyl chain; each substituted by phenyl, pyrrolidine, piperazine, morpholine or piperidine linked via a C1-3-alkyl chain and unsubstituted or monosubstituted by methyl or ethyl.
  • Very particular preference is given to substituted sulfonamide derivatives wherein the group
  • Figure US20080153843A1-20080626-C00046
  • represents
  • Figure US20080153843A1-20080626-C00047
  • Very particular preference is given to substituted sulfonamide compounds selected from the group consisting of
    • 1 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-N-(4-piperidin-1-ylmethyl-benzyl)-acetamide
    • 2 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-N-(4-piperidin-1-ylmethyl-benzyl)-acetamide
    • 3 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-N-[4-(4-methyl-piperazin-1-yl)-benzyl]-acetamide
    • 4 N-(4-piperidin-1-ylmethyl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
    • 5 1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-ethanone
    • 6 1-(4-benzyl-[1,4]diazepan-1-yl)-2-[1-(naphthyl-1-sulfonyl)-piperidin-2-ylmethoxy]-ethanone
    • 7 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-N-[4-(4-methyl-piperazin-1-ylmethyl)-benzyl]-acetamide
    • 8 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-ethanone
    • 9 1-(1,4′-bipiperidin-1′-yl)-2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl)methoxy)ethanone
    • 10 N-(4-piperidin-1-ylmethyl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-acetamide
    • 11 N-(4-dimethylaminomethyl-benzyl)-2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
    • 12 N-(1-benzyl-piperidin-3-ylmethyl)-2-[1-(2,4,6-trimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
    • 13 N-[4-(4-methyl-piperazin-1-yl)-benzyl]-2-[1-(2,4,6-trichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
    • 14 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-N-(4-piperidin-1-yl-benzyl)-acetamide
    • 15 N-[4-(4-methyl-piperazin-1-ylmethyl)-benzyl]-2-[1-(2,4,6-trichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
    • 16 N-(1-benzyl-piperidin-3-ylmethyl)-2-[1-(3,4-dichloro-phenylsulfonyl)-2,3-dihydro-1H-indol-2-ylmethoxy]-acetamide
    • 17 2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-pyrrolidin-1-yl)piperidin-1-yl)ethanone
    • 18 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-N-[4-(4-methyl-piperazin-1-yl)-benzyl]-acetamide
    • 19 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyrrolidin-1-yl)piperidin-1-yl)-ethanone
    • 20 2-((1-(3,4-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)-ethyl)piperidin-1-yl)ethanone
    • 21 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-N-(4-morpholin-4-yl-benzyl)-acetamide
    • 22 1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-[1-(3-trifluoromethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
    • 23 2-((1-(naphthalen-1-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyrrolidin-1-yl)piperidin-1-yl)ethanone
    • 24 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-N-(4-morpholin-4-ylmethyl-benzyl)-acetamide
    • 25 1-[4-(3-dimethylamino-propyl)-piperazin-1-yl]-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-ethanone
    • 26 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-(4-pyrrolidin-1-yl-piperidin-1-yl)-ethanone
    • 27 1-(2-piperidin-1-ylmethyl-pyrrolidin-1-yl)-2-[1-(2,4,6-trimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
    • 28 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-ethanone
    • 29 N-[4-(4-methyl-piperazin-1-yl)-benzyl]-2-[1-(2,4,6-trichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-acetamide
    • 30 N-(4-morpholin-4-ylmethyl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
    • 31 1-(4-benzyl-[1,4]diazepan-1-yl)-2-[1-(2,4,6-trimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
    • 32 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-ethanone
    • 33 N-[3-(4-methyl-piperazin-1-yl)-benzyl]-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-acetamide
    • 34 N-(1-benzyl-piperidin-3-ylmethyl)-2-[1-(naphthyl-1-sulfonyl)-piperidin-2-ylmethoxy]-acetamide
    • 35 N-(4-dimethylaminomethyl-benzyl)-2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-acetamide
    • 36 2-((1-(3,4-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)-ethyl)piperidin-1-yl)ethanone
    • 37 N-(4-dimethylaminomethyl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
    • 38 2-((2-(3,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(pyrrolidin-1-yl)piperidin-1-yl)ethanone
    • 39 1-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
    • 40 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-N-[4-(4-methyl-piperazin-1-ylmethyl)-benzyl]-acetamide
    • 41 N-(1-benzyl-piperidin-3-ylmethyl)-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-acetamide
    • 42 2-((1-(3,4-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)-ethyl)piperazin-1-yl)ethanone
    • 43 2-[2-(3,4-dichloro-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-N,N-bis-(2-diethylamino-ethyl)-acetamide
    • 44 1-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-2-[1-(3,4-dichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-ethanone
    • 45 N-[4-(4-methyl-piperazin-1-ylmethyl)-benzyl]-2-[1-(2,4,6-trichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-acetamide
    • 46 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(2-methoxy-ethyl)-piperazin-1-yl]-ethanone
    • 47 N-methyl-N-(2-morpholin-4-yl-1-phenyl-ethyl)-2-[1-(naphthyl-1-sulfonyl)-piperidin-2-ylmethoxy]-acetamide
    • 48 N,N-bis-(2-diethylamino-ethyl)-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetra-hydro-isoquinolin-3-ylmethoxy]-acetamide
    • 49 N-(4-morpholin-4-ylmethyl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-acetamide
    • 50 N-(3-morpholin-4-yl-benzyl)-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-acetamide
    • 51 2-[2-(2,4-dichloro-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-1-(2-piperidin-1-ylmethyl-pyrrolidin-1-yl)-ethanone
    • 52 2-((1-(4-methoxyphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)-ethyl)piperidin-1-yl)ethanone
    • 53 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(3-methoxy-phenyl)-piperazin-1-yl]-ethanone
    • 54 1-(4-cyclohexylmethyl-piperazin-1-yl)-2-[1-(3,4-dichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-ethanone
    • 55 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-N-(4-morpholin-4-ylmethyl-benzyl)-acetamide
    • 56 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-(4-phenyl-piperazin-1-yl)-ethanone
    • 57 1-(4-benzyl-piperidin-1-yl)-2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
    • 58 1-[4-(3-dimethylamino-propyl)-piperazin-1-yl]-2-[1-(3-trifluoromethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
    • 59 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone
    • 60 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-N-(4-piperidin-1-yl-benzyl)-acetamide
    • 61 N-(4-morpholin-4-ylmethyl-benzyl)-2-[1-(naphthyl-1-sulfonyl)-piperidin-2-ylmethoxy]-acetamide
    • 62 2-[1-(3,4-dichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-ethanone
    • 63 1-[2-(4-dimethylamino-phenyl)-azepan-1-yl]-2-[1-(naphthyl-1-sulfonyl)-piperidin-2-ylmethoxy]-ethanone
    • 64 2-[1-(naphthyl-1-sulfonyl)-piperidin-2-ylmethoxy]-1-(2-piperidin-1-ylmethyl-pyrrolidin-1-yl)-ethanone
    • 65 2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-morpholinopiperidin-1-yl)ethanone
    • 66 1-(3-dimethylamino-pyrrolidin-1-yl)-2-[1-(naphthyl-1-sulfonyl)-piperidin-2-ylethoxy]-ethanone
    • 67 1-(4-benzyl-[1,4]diazepan-1-yl)-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-ethanone
    • 68 1-(4-cyclohexylmethyl-piperazin-1-yl)-2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
    • 69 2-((2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(2-piperidin-1-yl)ethyl)piperidin-1-yl)ethanone
    • 70 N-(1-benzyl-piperidin-3-ylmethyl)-2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-yl-methoxy]-acetamide
    • 71 N-(4-piperidin-1-yl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-pyrrolidin-2-yl-methoxy]-acetamide
    • 72 2-((1-(3,4-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)-ethyl)piperazin-1-yl)ethanone
    • 73 N-(4-dimethylaminomethyl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-acetamide
    • 74 N-(4-piperidin-1-yl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-piperidin-2-yl-methoxy]-acetamide
    • 75 N-[2-(4-methyl-piperazin-1-yl)-benzyl]-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-acetamide
    • 76 N-(3-piperidin-1-ylmethyl-phenyl)-2-[1-(2,4,6-trimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
    • 77 1-[4-(3-methoxy-phenyl)-piperazin-1-yl]-2-[1-(2,4,6-trimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
    • 78 N-(1-benzyl-pyrrolidin-3-yl)-2-[2-(2,4-dichloro-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-N-methyl-acetamide
    • 79 1-(4-benzyl-[1,4]diazepan-1-yl)-2-[2-(2,4-dichloro-phenylsulfonyl)-1,2,3,4-tetra-hydro-isoquinolin-3-ylmethoxy]-ethanone
    • 80 N-[2-(4-methyl-piperazin-1-yl)-benzyl]-2-[1-(2,4,6-trimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
    • 81 2-[1-(3,4-dichloro-phenylsulfonyl)-2,3-dihydro-1H-indol-2-ylmethoxy]-N-(4-pyrrolidin-1-ylmethyl-benzyl)-acetamide
    • 82 2-[2-(3,4-dichloro-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-1-(2-piperidin-1-ylmethyl-pyrrolidin-1-yl)-ethanone
    • 83 N-(4-pyrrolidin-1-ylmethyl-benzyl)-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-acetamide
    • 84 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(4-methoxy-phenyl)-piperazin-1-yl]-ethanone
    • 85 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(3-dimethylamino-propyl)-piperazin-1-yl]-ethanone
    • 86 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(2-fluoro-phenyl)-piperazin-1-yl]-ethanone
    • 87 N-[4-(2-methyl-imidazol-1-yl)-phenyl]-2-[1-(2,4,6-trimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
    • 88 2-[1-(3,4-dichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-1-[4-(3-dimethylamino-propyl)-piperazin-1-yl]-ethanone
    • 89 2-[1-(3,4-dichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-1-(4-phenyl-piperazin-1-yl)-ethanone
    • 90 2-(2-(1-(4-methoxyphenylsulfonyl)piperidin-2-yl)ethoxy)-1-(4-(2-(piperidin-1-yl)-ethyl)piperidin-1-yl)ethanone
    • 91 2-(2-(1-(4-methoxyphenylsulfonyl)piperidin-2-yl)ethoxy)-1-(4-phenethylpiperazin-1-yl)ethanone
    • 92 3-((4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)-piperazin-1-yl)methyl)benzonitrile hydrochloride
    • 93 3-((4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetyl)-piperazin-1-yl)methyl)benzonitrile hydrochloride
    • 94 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone hydrochloride
    • 95 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
    • 96 1-(3,4-dihydro-2,6-naphthyridin-2(1H)-yl)-2-((1-(4-methoxy-2,6-dimethylphenyl-sulfonyl)piperidin-2-yl)methoxy)ethanone hydrochloride
    • 97 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 98 1-(4-(dihydro-1H-pyrido[1,2-a]pyrazin-2(6H,7H,8H,9H,9aH)-yl)piperidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 99 1-(4-dihydro-1H-pyrido[1,2-a]pyrazin-2(6H,7H,8H,9H,9aH)-yl)piperidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone dihydrochloride
    • 100 1-(4-(3,4-dihydro-2,6-naphthyridin-2(1H)-yl)piperidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 101 tert-butyl 4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperazin-1-carboxylate
    • 102 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone hydrochloride
    • 103 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)ethanone
    • 104 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(tetrahydro-2H-pyran-4-yl)piperazin-1-yl)ethanone
    • 105 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylcyclohexyl)piperazin-1-yl)ethanone
    • 106 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone dihydrochloride
    • 107 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 108 2-((1-(2,6-dichloro-4-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 109 2-((1-(2-chloro-6-methylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 110 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(naphthalen-1-ylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 111 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(naphthalen-2-ylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 112 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone hydrochloride
    • 113 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(thieno[3,2-d]pyrimidin-4-yl)piperazin-1-yl)ethanone
    • 114 2-((1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 115 2-((1-(4-chloro-3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 116 1-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperidin-4-one
    • 117 1-(4-((1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 118 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 119 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(2,4,6-triisopropylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 120 2-((1-(2,4-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 121 2-((1-(3-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 122 2-((1-(3-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
    • 123 2-((1-(4-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 124 2-((1-(3-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
    • 125 2-((1-(4-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
    • 126 2-((1-(4-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
    • 127 (S)-2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 128 2-((1-(5-chloro-1,3-dimethyl-1H-pyrazol-4-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 129 2-((1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 130 1-(4-fluoro-1,4′-bipiperidin-1′-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 131 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(3-(o-tolyloxy)phenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 133 (S)-2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 134 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-(trifluoromethyl)cyclohexyl)piperazin-1-yl)ethanone
    • 135 (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)azetidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 136 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-morpholin-2-(pyridin-3-yl)ethylamino)piperidin-1-yl)ethanone
    • 137 2-((1-(benzo[b]thiophen-3-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 138 2-((1-(2-chloro-4-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 139 2-((1-(2-chlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 140 (R)-2-((1-(4-methoxy-2,3,6-trimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 141 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 142 (S)-2-((2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 143 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(1-(pyridin-4-yl)piperidin-4-yl)ethyl)acetamide
    • 144 1-(4-(5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)piperidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 145 1-(4-(5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)piperidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 146 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-carbonyl)piperidin-1-yl)ethanone
    • 147 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
    • 148 2-((1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 149 2-((1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
    • 150 2-((1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
    • 151 2-((1-(5-chloro-3-methylbenzo[b]thiophen-2-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 152 (R)-2-((1-(2-chloro-6-methylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 153 2-((1-(2,5-bis(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 154 2-((1-(7-chlorobenzo[c][1,2,5]oxadiazol-4-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 155 2-((1-(4-methylnaphthalen-1-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 156 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(2,4,5-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone dihydrochloride
    • 157 2-((1-(2-methylnaphthalen-1-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 158 2-((1-(5-(dimethylamino)naphthalen-1-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 159 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(o-tolylsulfonyl)piperidin-2-yl)methoxy)ethanone dihydrochloride
    • 160 2-((1-(4-bromo-2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 161 (S)-2-((1-(2-chloro-6-methylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone hydrochloride
    • 162 (S)-2-((1-(2-chloro-6-methylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 163 (S)-2-((1-(2-chloro-6-methylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone dihydrochloride
    • 164 2-(2-(1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)ethoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 165 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-3-yloxy)piperidin-1-yl)ethanone
    • 166 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(quinoxalin-6-ylmethyl)piperazin-1-yl)ethanone
    • 167 (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 168 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-(pyrrolidin-1-yl)quinazolin-7-yl)piperazin-1-yl)ethanone
    • 169 2-((1-(4-fluoro-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 170 2-((1-(2,5-dichlorothiophen-3-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 171 2-((1-(benzo[b]thiophen-2-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 172 2-((1-(2,5-dimethylthiophen-3-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 173 2-((1-(2,3-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 174 2-((1-(4-methoxynaphthalen-1-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 175 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(quinolin-8-ylsulfonyl)piperidin-2-yl)methoxy)ethanone dihydrochloride
    • 176 2-((1-(isoquinolin-5-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 177 (R)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 178 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((2-(naphthalen-2-ylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)ethanone dihydrochloride
    • 179 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonyl)piperidin-2-yl)methoxy)ethanone dihydrochloride
    • 180 (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 181 (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone
    • 182 (S)-2-((2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
    • 183 (S)-2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
    • 184 (S)-2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone
    • 185 (S)-2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone
    • 186 (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yloxy)piperidin-1-yl)ethanone hydrochloride
    • 187 (S)-2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
    • 188 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-((pyridin-4-yloxy)methyl)piperidin-1-yl)ethanone
    • 189 (S)-2-((2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone dihydrochloride
    • 190 (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone hydrochloride
    • 191 2-((1-(2-chloronaphthalen-1-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
    • 192 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 193 N-(4-(4,5-dihydro-1H-imidazol-2-yl)benzyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methylacetamide hydrochloride
    • 194 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methyl-N-(2-(4-(pyrrolidin-1-yl)cyclohexyl)ethyl)acetamide
    • 195 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(pyrazin-2-yloxy)benzyl)acetamide
    • 196 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(pyrazin-2-yloxy)benzyl)acetamide
    • 197 1-(4-((5-chloro-2-phenyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 198 1-(4-((1,5-dimethyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 199 1-(4-((2-(dimethylamino)pyrimidin-5-yl)methyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 200 1-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)piperidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 201 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperidin-1-yl)ethanone
    • 202 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 203 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(naphthalen-2-ylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)ethanone
    • 204 2-((1-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 205 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(pyrazin-2-yloxy)benzyl)acetamide
    • 206 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(1H-pyrrol[3,4-c]pyridin-2(3H)-yl)ethanone
    • 207 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(pyridin-3-yl)morpholin)ethanone
    • 208 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(3-(pyridin-3-ylmethyl)pyrrolidin-1-yl)ethanone
    • 209 N-(2-(4-(dimethylamino)cyclohexyl)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methylacetamide
    • 210 2-((1-(6-methoxynaphthalen-2-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 211 1-(4-(3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)piperidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 212 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(1-methylpiperidin-4-yl)ethyl)piperazin-1-yl)ethanone
    • 213 2-((1-(3,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)-N-(2-(4-(dimethylamino)cyclohexyl)ethyl)-N-methylacetamide
    • 214 1-(4-((2-((4-fluorophenyl)(methyl)amino)pyrimidin-5-yl)methyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 215 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(6-(4-methylpiperazin-1-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone
    • 216 2-((1-(3,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)-N-methyl-N-(2-(4-(pyrrolidin-1-yl)cyclohexyl)ethyl)acetamide
    • 217 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-3-yl)piperidin-1-yl)ethanone
    • 218 N—((S)-1-benzylpyrrolidin-3-yl)-N-methyl-2-((1-(2-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 219 2-((1-(4-methoxyphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3-methylbenzyl)piperazin-1-yl)ethanone
    • 220 2-((1-(4-methoxyphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-phenethylthiazol-2-yl)piperazin-1-yl)ethanone
    • 221 2-(2-(1-(4-methoxyphenylsulfonyl)piperidin-2-yl)ethoxy)-1-(4-(2-(piperidin-1-yl)ethyl)piperazin-1-yl)ethanone
    • 222 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(5-methyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethanone
    • 223 1-(2-((4,6-dimethylpyridin-2-yl)methyl)piperidin-1-yl)-2-((2-(mesitylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)ethanone
    • 224 1-(2-(5-bromopyridin-3-yl)piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 225 1-(1,4′-bipiperidin-1-yl)-2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 226 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(pyridin-2-ylmethyl)pyrrolidin-1-yl)ethanone
    • 227 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(6-methoxypyridin-3-yl)piperidin-1-yl)ethanone
    • 228 1-(2-((5-ethylpyridin-2-yl)methyl)piperidin-1-yl)-2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 229 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(2-((3-methylpyridin-2-yl)methyl)piperidin-1-yl)ethanone
    • 230 1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)-2-((1-(naphthen-1-ylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 231 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
    • 232 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone
    • 233 2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
    • 234 1-(4-(4-benzylthiazol-2-yl)piperazin-1-yl)-2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 235 1-(1,4′-bipiperidin-1′-yl)-2-((1-(naphthen-1-ylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 236 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(3-(pyridin-2-yl)pyrrolidin-1-yl)ethanone
    • 237 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(3-(pyridin-3-yl)pyrrolidin-1-yl)ethanone
    • 238 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(3-(pyridin-4-yl)pyrrolidin-1-yl)ethanone
    • 239 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methyl-N-(2-(pyridin-4-yl)ethyl)acetamide
    • 240 1-(2-((4,6-dimethylpyridin-2-yl)methyl)pyrrolidin-1-yl)-2-((1-(naphthen-1-ylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 241 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methyl-N-(1-phenyl-2-(pyrrolidin-1-yl)ethyl)acetamide
    • 242 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-methylpiperazin-1-yl)ethanone
    • 243 N-(2-(1H-indol-3-yl)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 244 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-methylquinolin-4-yl)acetamide
    • 245 1-(4-(2-ethoxyethyl)piperazin-1-yl)-2-((2-(mesitylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)ethanone
    • 246 2-((2-(mesitylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(2-methoxyethyl)piperazin-1-yl)ethanone
    • 247 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(pyridin-2-yl)pyrrolidin-1-yl)ethanone
    • 248 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(4-methylpiperazin-1-yl)ethyl)acetamide
    • 249 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-morpholin-2-(4-(trifluoromethyl)phenyl)ethyl)acetamide
    • 250 N-(5-(dimethylamino)pentyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 251 N-(2-(2-chlorophenyl)-2-morpholinoethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 252 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(4-methoxyphenyl)-2-(pyrrolidin-1-yl)ethyl)acetamide
    • 253 1-(4-(3,5-dimethoxyphenyl)piperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 254 1-(4-(2-(diisopropylamino)ethyl)piperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 255 N-(1-benzylpiperidin-4-yl)-N-cyclopropyl-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 256 N-(2-morpholino-2-(pyridin-3-yl)ethyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 257 N-(1-ethyl-1H-pyrazol-5-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 258 N-(isoquinolin-5-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 259 N-(2-(dimethylamino)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 260 N-(3-(2,6-dimethylpiperidin-1-yl)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 261 N-(2-(dimethylamino)-1-phenylethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 262 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(1-phenyl-2-(pyrrolidin-1-yl)ethyl)acetamide
    • 263 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(4-methylpiperazin-1-yl)-1-phenylethyl)acetamide
    • 264 N-(3-morpholinophenyl)-2-((2-(phenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)acetamide
    • 265 2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-N-(3-morpholinophenyl)acetamide
    • 266 2-((1-(3,4-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(piperidin-1-ylmethyl)morpholino)ethanone
    • 267 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
    • 268 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)ethyl)piperidin-1-yl)ethanone
    • 269 1-(4-(2-(2,5-dimethyl-1H-pyrrol-1-yl)ethyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 270 1-(4-(2-(diisopropylamino)ethyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 271 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(2-(pyridin-2-yl)pyrrolidin-1-yl)ethanone
    • 272 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(3-(pyridin-3-yl)pyrrolidin-1-yl)ethanone
    • 273 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(3-(pyridin-4-yl)pyrrolidin-1-yl)ethanone
    • 274 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
    • 275 2-((2-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
    • 276 2-((2-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(2-(piperidin-1-yl)ethyl)piperidin-1-yl)ethanone
    • 277 2-((2-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(2-((6-methylpyridin-2-yl)methyl)piperidin-1-yl)ethanone
    • 278 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
    • 279 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)ethyl)piperidin-1-yl)ethanone
    • 280 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(2,5-dimethyl-1H-pyrrol-1-yl)ethyl)piperazin-1-yl)ethanone
    • 281 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(diisopropylamino)ethyl)piperazin-1-yl)ethanone
    • 282 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(3-(pyridin-4-yl)pyrrolidin-1-yl)ethanone
    • 283 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
    • 284 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-((6-methylpyridin-2-yl)methyl)piperidin-1-yl)ethanone
    • 285 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
    • 286 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)ethyl)piperidin-1-yl)ethanone
    • 287 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(2,5-dimethyl-1H-pyrrol-1-yl)ethyl)piperazin-1-yl)ethanone
    • 288 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3-methoxyphenyl)piperazin-1-yl)ethanone
    • 289 1-(4-(4-fluorophenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 290 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methoxyphenyl)piperazin-1-yl)ethanone
    • 291 1-(4-isopropylpiperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 292 2-((2-(mesitylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
    • 293 2-((1-(3,4-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(pyrrolidin-1-ylmethyl)phenyl)acetamide
    • 294 N-(4-(dimethylamino)butyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 295 1-(4-ethylpiperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 296 1-(4-(pyrrolidin-1-yl)piperidin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 297 1-(4-morpholinopiperidin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 298 1-(1,4′-bipiperidin-1′-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 299 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-(pyrrolidin-1-ylmethyl)benzyl)acetamide
    • 300 N-((1-benzylpiperidin-3-yl)methyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 301 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-(4-methylpiperazin-1-yl)phenyl)acetamide
    • 302 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-(4-methylpiperazin-1-yl)benzyl)acetamide
    • 303 N—((S)-1-benzylpyrrolidin-3-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-methylacetamide
    • 304 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-methyl-N-(2-morpholino-1-phenylethyl)acetamide
    • 305 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(pyridin-2-yl)piperazin-1-yl)ethanone
    • 306 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(3-methoxyphenyl)piperazin-1-yl)ethanone
    • 307 1-(4-(4-fluorophenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 308 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(4-methoxyphenyl)piperazin-1-yl)ethanone
    • 309 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(pyrimidin-2-yl)piperazin-1-yl)ethanone
    • 310 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-phenethylpiperazin-1-yl)ethanone
    • 311 1-(4-(5-chloro-2-methylphenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 312 2-(4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetyl)piperazin-1-yl)nicotinonitrile
    • 313 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(pyrrolidin-1-ylmethyl)benzyl)acetamide
    • 314 N-((1-benzylpiperidin-3-yl)methyl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 315 N—((S)-1-benzylpyrrolidin-3-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-methylacetamide
    • 316 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-2-yl)piperazin-1-yl)ethanone
    • 317 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3-methoxyphenyl)piperazin-1-yl)ethanone
    • 318 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-fluorophenyl)piperazin-1-yl)ethanone
    • 319 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methoxyphenyl)piperazin-1-yl)ethanone
    • 320 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenethylpiperazin-1-yl)ethanone
    • 321 1-(4-(5-chloro-2-methylphenyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 322 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-(pyrrolidin-1-ylmethyl)benzyl)acetamide
    • 323 N-((1-benzylpiperidin-3-yl)methyl)-2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 324 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(3-methoxyphenyl)piperazin-1-yl)ethanone
    • 325 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(4-methoxyphenyl)piperazin-1-yl)ethanone
    • 326 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-phenethylpiperazin-1-yl)ethanone
    • 327 N-((1-benzylpiperidin-3-yl)methyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 328 1-(4-(4-methoxyphenyl)piperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 329 1-(4-phenethylpiperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 330 1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 331 1-(4-(2-(piperidin-1-yl)ethyl)piperidin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 332 1-(4-(2-(2,5-dimethyl-1H-pyrrol-1-yl)ethyl)piperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 333 1-(4-(2-(diisopropylamino)ethyl)piperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 334 N-(1-benzylpiperidin-4-yl)-N-cyclopropyl-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 335 1-(4-(pyridin-4-yl)piperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 336 1-(1,4′-bipiperidin-1′-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 337 1-(1,4′-bipiperidin-1′-yl)-2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 338 N-(2-(piperidin-1-yl)ethyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 339 N-(2-(pyrrolidin-1-yl)ethyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 340 1-(4-(3,5-dimethoxyphenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 341 1-(4-(2-(diisopropylamino)ethyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 342 N-(1-benzylpiperidin-4-yl)-N-cyclopropyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 343 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(pyrrolidin-1-yl)ethyl)acetamide
    • 344 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-morpholinopropyl)acetamide
    • 345 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(pyridin-3-ylmethyl)acetamide
    • 346 1-(4-(3-chlorophenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 347 1-(4-(3,4-dimethylphenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 348 1-(4-(3,4-dichlorophenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 349 1-(4-(3,4-dichlorobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 350 1-(4-(4-bromobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 351 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2,4,6-trimethylbenzyl)piperazin-1-yl)ethanone
    • 352 1-(4-(4-chlorobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 353 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(4-methylbenzyl)piperazin-1-yl)ethanone
    • 354 1-(4-(3-chlorophenyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 355 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(3,4-dimethylphenyl)piperazin-1-yl)ethanone
    • 356 1-(4-(3,4-dichlorophenyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 357 1-(4-(3,4-dichlorobenzyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 358 1-(4-(4-bromobenzyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 359 1-(4-(4-chlorobenzyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 360 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(4-methylbenzyl)piperazin-1-yl)ethanone
    • 361 N-benzyl-N-(2-(dimethylamino)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 362 1-(4-benzyl-1,4-diazepan-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 363 1-((R)-3-(dimethylamino)pyrrolidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 364 N—((S)-1-benzylpyrrolidin-3-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methylacetamide
    • 365 N-(1-benzylpyrrolidin-3-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 366 N-(3-(1H-imidazol-1-yl)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 367 N-(4-(dimethylamino)benzyl)-N-isopropyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 368 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methyl-N-(2-morpholino-1-phenylethyl)acetamide
    • 369 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-2-yl)piperazin-1-yl)ethanone
    • 370 N-(isoquinolin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 371 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(1-methyl-1H-benzo[d]imidazol-2-yl)acetamide
    • 372 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(pyrimidin-4-yl)acetamide
    • 373 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenethylpiperazin-1-yl)ethanone
    • 374 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-((S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)ethanone
    • 375 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-methyl-1,4-diazepan-1-yl)ethanone
    • 376 1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 377 N-benzyl-N-(2-(dimethylamino)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 378 1-(4-(3,4-dichlorophenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 379 N-(2-(dimethylamino)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methylacetamide
    • 380 N-(2-(diethylamino)ethyl)-N-ethyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 381 1-(4-(3,4-dichlorobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 382 1-(4-(4-bromobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 383 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2,4,6-trimethylbenzyl)piperazin-1-yl)ethanone
    • 384 1-(4-(4-chlorobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 385 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylbenzyl)piperazin-1-yl)ethanone
    • 386 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methoxybenzyl)piperazin-1-yl)ethanone
    • 387 1-(4-(2-fluorobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 388 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-methyl-2-phenylpiperazin-1-yl)ethanone
    • 389 1-(3-(pyridin-3-yl)pyrrolidin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 390 1-(3-(pyridin-4-yl)pyrrolidin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 391 N-methyl-N-(2-(pyridin-4-yl)ethyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 392 N-methyl-N-(1-phenyl-2-(pyrrolidin-1-yl)ethyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 393 1-(4-methylpiperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 394 N-(pyridin-4-ylmethyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 395 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-morpholinopyridin-3-yl)acetamide
    • 396 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(6-morpholinopyridin-3-yl)acetamide
    • 397 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(5-methyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethanone
    • 398 1-(2-(4-(dimethylamino)phenyl)pyrrolidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 399 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(piperidin-1-ylmethyl)pyrrolidin-1-yl)ethanone
    • 400 1-(2-(4-(dimethylamino)phenyl)azepan-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 401 N-(2-(4-benzylpiperazin-1-yl)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 402 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-phenylthiazol-2-yl)piperazin-1-yl)ethanone
    • 403 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3,4-dimethylphenyl)piperazin-1-yl)ethanone
    • 404 1-(4-(3,4-dichlorophenyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 405 1-(4-(3,4-dichlorobenzyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 406 1-(4-(4-bromobenzyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 407 1-(4-(4-chlorobenzyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 408 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylbenzyl)piperazin-1-yl)ethanone
    • 409 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(pyrrolidin-1-yl)phenyl)acetamide
    • 410 3-(4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperazin-1-yl)propanenitrile
    • 411 N-(3-(4-benzylpiperazin-1-yl)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 412 N-(3-(4-ethylpiperazin-1-yl)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 413 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(piperidin-1-yl)propyl)acetamide
    • 414 N-((1-benzylpyrrolidin-3-yl)methyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 415 N-((1-benzylpiperidin-3-yl)methyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 416 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(5-methyl-1H-pyrazol-1-yl)ethyl)acetamide
    • 417 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethyl)phenyl)acetamide
    • 418 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(piperidin-1-ylmethyl)phenyl)acetamide
    • 419 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(piperidin-1-ylmethyl)phenyl)acetamide
    • 420 N-(4-((1H-imidazol-1-yl)methyl)phenyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 421 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-((4-methylpiperidin-1-yl)methyl)phenyl)acetamide
    • 422 N-((1-benzylpiperidin-3-yl)methyl)-2-((1-(4-methoxyphenylsulfonyl)indolin-2-yl)methoxy)acetamide
    • 423 2-((1-(4-methoxyphenylsulfonyl)indolin-2-yl)methoxy)-N-(3-(piperidin-1-ylmethyl)phenyl)acetamide
    • 424 N-(3-(ethyl(phenyl)amino)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 425 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(pyrazin-2-yl)ethyl)acetamide
    • 426 N-(1-(1H-pyrazol-1-yl)propan-2-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 427 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(2-methyl-1H-imidazol-1-yl)phenyl)acetamide
    • 428 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(piperidin-1-yl)benzyl)acetamide
    • 429 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(piperidin-1-yl)phenyl)acetamide
    • 430 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(piperidin-1-yl)benzyl)acetamide
    • 431 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(4-methylpiperazin-1-yl)phenyl)acetamide
    • 432 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(4-methylpiperazin-1-yl)benzyl)acetamide
    • 433 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(4-methylpiperazin-1-yl)benzyl)acetamide
    • 434 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(4-methylpiperazin-1-yl)benzyl)acetamide
    • 435 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-morpholinobenzyl)acetamide
    • 436 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-morpholinophenyl)acetamide
    • 437 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-morpholinobenzyl)acetamide
    • 438 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-morpholinophenyl)acetamide
    • 439 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-morpholinobenzyl)acetamide
    • 440 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(piperidin-1-yl)ethyl)acetamide
    • 441 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(dimethylamino)butyl)acetamide
    • 442 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-fluorophenyl)piperazin-1-yl)ethanone
    • 443 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyrrolidin-1-yl)piperidin-1-yl)ethanone
    • 444 1-(4-(2-fluorobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 445 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-methyl-2-phenylpiperazin-1-yl)ethanone
    • 446 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-methyl-N-(2-(4-methylpiperazin-1-yl)-1-phenylethyl)acetamide
    • 447 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(2-(pyridin-2-ylmethyl)pyrrolidin-1-yl)ethanone
    • 448 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(2-((6-methylpyridin-2-yl)methyl)pyrrolidin-1-yl)ethanone
    • 449 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(2-(pyridin-2-ylmethyl)piperidin-1-yl)ethanone
    • 450 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-methyl-N-(1-phenyl-2-(pyrrolidin-1-yl)ethyl)acetamide
    • 451 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(4-methoxybenzyl)piperazin-1-yl)ethanone
    • 452 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(dimethylamino)ethyl)piperazin-1-yl)ethanone
    • 453 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(2-(pyridin-4-ylmethyl)piperidin-1-yl)ethanone
    • 454 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-fluorobenzyl)piperazin-1-yl)ethanone
    • 455 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-methyl-2-phenylpiperazin-1-yl)ethanone
    • 456 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(pyridin-2-ylmethyl)pyrrolidin-1-yl)ethanone
    • 457 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-((4,6-dimethylpyridin-2-yl)methyl)pyrrolidin-1-yl)ethanone
    • 458 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-((6-methylpyridin-2-yl)methyl)pyrrolidin-1-yl)ethanone
    • 459 N-(2-(pyrrolidin-1-yl)ethyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 460 1-(4-benzylpiperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 461 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-phenylpiperazin-1-yl)ethanone
    • 462 1-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 463 N-benzyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-methylpyridin-2-yl)acetamide
    • 464 N-benzyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(6-methylpyridin-2-yl)acetamide
    • 465 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone
    • 466 N-ethyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(pyridin-4-ylmethyl)acetamide
    • 467 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-methyl-1,4-diazepan-1-yl)ethanone
    • 468 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)ethanone
    • 469 1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 470 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethyl)phenyl)acetamide
    • 471 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(3-(piperidin-1-ylmethyl)phenyl)acetamide
    • 472 N-(4-(2-(1H-benzo[d]imidazol-2-yl)ethyl)phenyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 473 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(2-(4-methylpiperazin-1-yl)benzyl)acetamide
    • 474 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(5-methyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethanone
    • 475 1-(2-(4-(dimethylamino)phenyl)azepan-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 476 1-((R)-3-(dimethylamino)pyrrolidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 477 N-(1-benzylpiperidin-4-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 478 1-(4-benzylpiperazin-1-yl)-2-((1-(2,5-dichlorothiophen-3-ylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 479 2-((2-(4-Methoxy-2,3,6-trimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-phenylpiperazin-1-yl)ethanone
    • 480 1-(4-benzylpiperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 481 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone
    • 482 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-ethyl-N-(pyridin-4-ylmethyl)acetamide
    • 483 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-methyl-1,4-diazepan-1-yl)ethanone
    • 484 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)ethanone
    • 485 1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 486 N-benzyl-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(pyridin-2-yl)acetamide
    • 487 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(5-methyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethanone
    • 488 N-(1-benzylpiperidin-4-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 489 N-benzyl-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(dimethylamino)ethyl)acetamide
    • 490 1-(2-((5-ethylpyridin-2-yl)methyl)pyrrolidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 491 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-methoxyphenyl)piperazin-1-yl)ethanone
    • 492 1-(4-(cyclohexylmethyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 493 N-(3-chloro-4-morpholinophenyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 494 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(1-methyl-1H-benzo[d]imidazol-5-yl)acetamide
    • 495 N-(2-(dimethylamino)-2-(4-(trifluoromethyl)phenyl)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 496 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(2-(pyrrolidin-1-yl)-2-(4-(trifluoromethyl)phenyl)ethyl)acetamide
    • 497 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(pyridin-3-yl)pyrrolidin-1-yl)ethanone
    • 498 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-methoxyphenyl)piperazin-1-yl)ethanone
    • 499 1-(4-(cyclohexylmethyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 500 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(2-morpholino-1-phenylethyl)acetamide
    • 501 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(1-methyl-1H-indazol-6-yl)acetamide
    • 502 N-(2-(2-chlorophenyl)-2-(pyrrolidin-1-yl)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 503 1-(4-(3,5-dimethoxyphenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 504 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(1-methyl-1H-benzo[d]imidazol-2-yl)acetamide
    • 505 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(1-phenyl-2-(pyrrolidin-1-yl)ethyl)acetamide
    • 506 3-(4-(2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperazin-1-yl)propanenitrile
    • 507 N-benzyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-methylpyridin-2-yl)acetamide
    • 508 N-benzyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(6-methylpyridin-2-yl)acetamide
    • 509 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone
    • 510 N-ethyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(pyridin-4-ylmethyl)acetamide
    • 511 1-(4-(3-chlorophenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 512 1-(4-(3,4-dimethylphenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 513 2-(4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperazin-1-yl)nicotinonitrile
    • 514 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(5-(trifluoro methyl)pyridin-2-yl)piperazin-1-yl)ethanone
    • 515 N-benzyl-2-((1-(2,5-dichlorothiophen-3-ylsulfonyl)piperidin-2-yl)methoxy)-N-(6-methylpyridin-2-yl)acetamide
    • 516 1-(4-(2-fluorophenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 517 1-(4-ethylpiperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 518 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(pyrrolidin-1-yl)piperidin-1-yl)ethanone
    • 519 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-morpholinopiperidin-1-yl)ethanone
    • 520 1-(1,4′-bipiperidin-1′-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
    • 521 N-(3-(4-benzylpiperazin-1-yl)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 522 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(3-(piperidin-1-yl)propyl)acetamide
    • 523 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-(pyrrolidin-1-yl)butyl)acetamide
    • 524 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
    • 525 N-(3-(1H-benzo[d]imidazol-2-yl)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 526 1-(4-(benzo[d]thiazol-2-yl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 527 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(2-methyl-1H-imidazol-1-yl)phenyl)acetamide
    • 528 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(4-(dimethylamino)phenyl)pyrrolidin-1-yl)ethanone
    • 529 1-(4-benzyl-1,4-diazepan-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 530 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(dimethylamino)benzyl)-N-isopropylacetamide
    • 531 2-(4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetyl)-1,4-diazepan-1-yl)nicotinonitrile
    • 532 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methyl-N-(2-(piperidin-1-yl)ethyl)acetamide
    • 533 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)ethyl)piperidin-1-yl)ethanone
    • 534 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(2-morpholinoethyl)piperidin-1-yl)ethanone
    • 535 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(5-methyl-1H-pyrazol-3-yl)acetamide
    • 536 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(5-phenyl-1H-pyrazol-3-yl)acetamide
    • 537 N-(3-(4-chlorophenyl)-1H-pyrazol-5-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 538 N-(4-(3,4-dimethoxyphenyl)-1H-pyrazol-5-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 539 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(thiophen-2-yl)-1H-pyrazol-5-yl)acetamide
    • 540 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(5-(2-methoxyphenyl)-1H-pyrazol-3-yl)acetamide
    • 541 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(5-(3-methoxyphenyl)-1H-pyrazol-3-yl)acetamide
    • 542 N-(5-(3-fluorophenyl)-1H-pyrazol-3-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 543 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(5-(4-methoxyphenyl)-1H-pyrazol-3-yl)acetamide
    • 544 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-p-tolyl-1H-pyrazol-5-yl)acetamide
    • 545 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-phenyl-1H-pyrazol-5-yl)acetamide
    • 546 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(quinolin-2-yl)acetamide
    • 547 2-((1-(4-methoxyphenylsulfonyl)indolin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)ethyl)piperidin-1-yl)ethanone
    • 548 1-(4-(2-(2,5-dimethyl-1H-pyrrol-1-yl)ethyl)piperazin-1-yl)-2-((1-(4-methoxyphenylsulfonyl)indolin-2-yl)methoxy)ethanone
    • 549 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(morpholinomethyl)benzyl)acetamide
    • 550 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone
    • 551 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3,5-dichloropyridin-2-yl)piperazin-1-yl)ethanone
    • 552 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-hydroxyethyl)piperazin-1-yl)ethanone
    • 553 1-(4-(benzo[d]thiazol-2-yl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 554 1-(4-(6-chlorobenzo[d]thiazol-2-yl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 555 N-(4-(4-ethylpiperazin-1-yl)phenyl)-2-((1-(4-methoxyphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 556 2-((1-(4-methoxyphenylsulfonyl)piperidin-2-yl)methoxy)-N-(7-morpholinobenzo[c][1,2,5]oxadiazol-4-yl)acetamide
    • 557 2-((1-(4-methoxyphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-methyl-4-(2-(piperidin-1-yl)acetamideo)phenyl)acetamide
    • 558 2-((1-(4-methoxyphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-phenoxyethyl)piperazin-1-yl)ethanone
    • 559 1-(4-(2-(2,5-dimethyl-1H-pyrrol-1-yl)ethyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 560 1-(4-(3-(dimethylamino)propyl)piperazin-1-yl)-2-((2-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)ethanone
    • 561 N,N-bis(3-(dimethylamino)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 562 2-((2-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 563 2-((2-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone
    • 564 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3-(dimethylamino)propyl)piperazin-1-yl)ethanone
    • 565 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 566 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(3-(dimethylamino)propyl)piperazin-1-yl)ethanone
    • 567 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 568 1-(4-benzylpiperazin-1-yl)-2-((1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 569 2-((1-(2,6-dichloro-4-(trifluoromethyl)phenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(3-(dimethylamino)propyl)piperazin-1-yl)ethanone
    • 570 2-((1-(2,6-dichloro-4-(trifluoromethyl)phenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
    • 571 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(2-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)ethanone
    • 572 2-((1-(benzo[b]thiophen-3-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
    • 573 2-((1-(benzo[b]thiophen-3-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone
    • 574 N—((S)-1-benzylpyrrolidin-3-yl)-2-((1-(2,6-dichloro-4-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)-N-methylacetamide
    • 575 N-(4-(dimethylamino)benzyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 576 N-(4-(dimethylamino)benzyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 577 N-(4-(dimethylamino)benzyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 578 N-(4-(dimethylamino)benzyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
    • 579 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-morpholinobenzyl)acetamide
    • 580 N-(4-morpholinobenzyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
    • 581 N-(4-morpholinobenzyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
      in the form of the racemate; in the form of the enantiomers, diastereoisomers, mixtures of the enantiomers or diastereoisomers or in the form of an individual enantiomer or diastereoisomer; in the form of the bases and/or salts of physiologically acceptable acids.
  • The numbering of the individual forms of the substances according to the invention that is used above is retained in the explanations of the present invention that follow, in particular in the description of the examples.
  • The compounds according to the invention exhibit an antagonistic action on the human B1R receptor or the B1R receptor of the rat. In a preferred embodiment of the invention, the substances according to the invention exhibit an antagonistic action both on the human B1R receptor and on the B1R receptor of the rat.
  • Particular preference is given to compounds which exhibit at least 15%, 25%, 50%, 70%, 80% or 90% inhibition on the human B1R receptor and/or on the B1R receptor of the rat in the FLIPR assay at a concentration of 10 μM. Most particular preference is given to compounds which exhibit at least 70%, especially 80% and particularly preferably 90% inhibition on the human B1R receptor and on the B1R receptor of the rat.
  • The agonistic or antagonistic action of substances can be quantified on the bradykinin receptor 1 (B1R) of the species human and rat with ectopically expressing cell lines (CHO K1 cells) and with the aid of a Ca2+-sensitive dye (Fluo-4) using a fluorescent imaging plate reader (FLIPR). The indication in % activation is based on the Ca2+ signal after addition of Lys-Des-Arg9-bradykinin (0.5 nM) or Des-Arg9-bradykinin (100 nM). Antagonists result in a suppression of the Ca2+ influx following administration of the agonist. The % inhibition in comparison with the maximum achievable inhibition is indicated.
  • The substances according to the invention are active, for example, on B1R, which is relevant in connection with various diseases, so that they are suitable as a pharmaceutical active ingredient in a medicament. The invention therefore further provides pharmaceutical compositions or medicaments comprising at least one substituted sulfonamide derivative according to the invention as well as, optionally, suitable additives and/or auxiliary substances and/or, optionally, further active ingredients.
  • In addition to comprising at least one substituted sulfonamide derivative according to the invention, the pharmaceutical compositions according to the invention optionally comprise suitable additives and/or auxiliary substances, that is to say carriers, fillers, solvents, diluents, colorings and/or binders, and can be administered as liquid pharmaceutical dosage forms in the form of injection solutions, drops or juices, as semi-solid pharmaceutical dosage forms in the form of granules, tablets, pellets, patches, capsules, plasters/spray-on plasters or aerosols. The choice of auxiliary substances etc. and the amounts thereof to be used depend on whether the medicament is to be administered orally, perorally, parenterally, intravenously, intraperitoneally, intradermally, intramuscularly, intranasally, buccally, rectally or locally, for example to the skin, the mucosa or to the eyes. Preparations suitable for oral administration are in the form of tablets, dragées, capsules, granules, drops, juices and syrups, and those suitable for parenteral and topical administration and administration by inhalation are solutions, suspensions, readily reconstitutable dry preparations and sprays. Substituted sulfonamide derivatives according to the invention in a depot, in dissolved form or in a plaster, optionally with the addition of agents promoting penetration through the skin, are suitable percutaneous forms of administration. Forms of preparation for oral or percutaneous administration can release the substituted sulfonamide derivatives according to the invention in a delayed manner. The substituted sulfonamide derivatives according to the invention can also be administered in parenteral long-term depot forms, such as, for example, implants or implanted pumps. In principle, other further active ingredients known to the person skilled in the art can be added to the medicaments according to the invention.
  • The amount of active ingredient to be administered to the patient varies depending on the weight of the patient, the manner of administration, the indication and the severity of the disease. Usually, from 0.00005 to 50 mg/kg, preferably from 0.01 to 5 mg/kg, of at least one substituted sulfonamide derivative according to the invention are administered.
  • In a preferred form of the pharmaceutical composition or medicament, a substituted sulfonamide derivative according to the invention that is present is in the form of a pure diastereoisomer and/or enantiomer, in the form of a racemate or in the form of a non-equimolar or equimolar mixture of the diastereoisomers and/or enantiomers.
  • B1R has been identified in particular in occurrences of pain. Accordingly, substituted sulfonamide derivatives according to the invention can be used in the treatment of pain, in particular of acute, visceral, neuropathic or chronic pain. The invention accordingly relates further to the use of a substituted sulfonamide derivative according to the invention in the treatment of pain, in particular of acute, visceral, neuropathic or chronic pain. The invention relates further to the use of a substituted sulfonamide derivative according to the invention in the treatment of diabetes, respiratory diseases, inflammatory intestinal diseases, neurological diseases, inflammations of the skin, rheumatic diseases, septic shock, reperfusion syndrome and obesity, and as an angiogenesis inhibitor.
  • In one of the above uses it can be preferred for a substituted sulfonamide derivative that is used to be in the form of a pure diastereoisomer and/or enantiomer, in the form of a racemate or in the form of a non-equimolar or equimolar mixture of the diastereoisomers and/or enantiomers.
  • The invention further provides a method of treating, in particular in one of the above-mentioned indications, a non-human mammal or a human requiring treatment for pain, in particular for chronic pain, by administering a therapeutically effective dose of a substituted sulfonamide derivative according to the invention or of a medicament according to the invention.
  • The invention further provides a process for the preparation of the substituted sulfonamide derivatives according to the invention as set out in the following description, examples and claims. The compounds according to the invention can be obtained according to the following synthesis scheme.
  • Figure US20080153843A1-20080626-C00048
  • According to method 1, the racemic (R and S configuration) or enantiomerically pure (R or S configuration) amino acids/acid esters A are converted into an amino alcohol B by means of a reduction, using metal hydrides as reducing agents, such as, for example, LiAlH4, BH3×DMS, BH3×THF or NaBH4, in an organic solvent, such as THF or diethyl ether, in a temperature range of from −20° C. to +100° C., preferably at from 0° C. to +70° C. The amino alcohols B are converted into the sulfonylated amino alcohols G in a sulfonylation using sulfonyl chlorides, bromides or pentafluorophenolates R1SO2X (X═Br, Cl or OPFP) in the presence of an organic or inorganic base, for example potassium carbonate, sodium hydrogen carbonate, diisopropylethylamine, triethylamine, pyridine, diethylamine or dimethylaminopyridine, or in the presence of tetra-n-butylammonium chloride and in an organic solvent, for example acetonitrile, dichloromethane or N,N-dimethylformamide, in a temperature range of from 0° C. to +120° C.
    In method 2, the racemic (R and S configuration) or enantiomerically pure (R or S configuration) amino acids C are esterified to the amino esters D using water-removing reagents, for example inorganic acids such as H2SO4 or phosphorus oxides, or organic reagents, such as thionyl chloride, in organic solvents, such as THF, diethyl ether, methanol, ethanol or dichloromethane, in a temperature range of from 0° C. to the boiling temperature of the solvent in question, preferably at 40° C., and are then converted into the sulfonylated amino esters E in a sulfonylation using sulfonyl chlorides or bromides RSO2X (X═Br or Cl) in the presence of an organic or inorganic base, for example potassium carbonate, sodium hydrogen carbonate, diisopropylethylamine, pyridine, diethylamine or triethylamine, and in an organic solvent, for example acetonitrile or dichloromethane, in a temperature range of from 0° C. to +25° C., which sulfonylated amino esters E, in an ester cleavage using organic acids, such as trifluoroacetic acid, or aqueous inorganic acids, such as hydrochloric acid, or using aqueous inorganic bases, such as lithium hydroxide, potassium hydroxide, sodium hydroxide, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, in organic solvents, such as methanol, dioxane, dichloromethane, THF, diethyl ether or those solvents in the form of mixtures, in a temperature range of from −20° C. to +25° C., preferably at room temperature, yield the sulfonylated amino acids F. The sulfonylated amino alcohols G are then converted into the products of the general structure H in an alkylation reaction with halogenated ester derivatives using tetrabutyl-ammonium chloride or bromide or tetrabutylammonium hydrogen sulfate in a phase-transfer reaction using an organic solvent, such as toluene, benzene or xylene, and inorganic base, such as potassium hydroxide, sodium hydroxide, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, or in the presence of an organic or inorganic base, conventional inorganic bases are metal alcoholates, such as sodium methanolate, sodium ethanolate, potassium tert-butoxide, lithium or sodium bases, such as lithium diisopropylamide, butyllithium, tert-butyllithium, sodium methoxide, or metal hydrides, such as potassium hydride, lithium hydride, sodium hydride; conventional organic bases are diisopropylethylamine, triethylamine, in an organic solvent, such as dichloromethane, THF or diethyl ether, in a temperature range of from −20° C. to +25° C., preferably at from 0° C. to +25° C., which products of the general structure H, in an ester cleavage using organic acids, such as trifluoroacetic acid, or aqueous inorganic acids, such as hydrochloric acid, or using aqueous inorganic bases, such as lithium hydroxide, potassium hydroxide, sodium hydroxide, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, in organic solvents, such as methanol, dioxane, dichloromethane, THF, diethyl ether or those solvents in the form of mixtures, in a temperature range of from 0° C. to +25° C., yield the acid stages of the general formula I. The carboxylic acids I are converted into the end products of the general formula J in an amide formation using primary or secondary amines, in the presence of water-removing agents, such as sodium or magnesium sulfate, phosphorus oxide or reagents such as, for example, CDI, DCC, TBTU, EDCI or benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP), also in the presence of HOAt or HOBt and of an organic base, for example DIPEA, pyridine or 4-methylmorpholine, in an organic solvent, such as THF, dichloromethane, diethyl ether, dioxane, DMF or acetonitrile, 0° C. to +40° C., preferably at room temperature.
  • Figure US20080153843A1-20080626-C00049
  • Commercially available amino alcohols are used as structural units B in the synthesis process and are converted into the end products of the general formula J in the manner described in methods 1 and 2.
  • Compounds corresponding to formula I in which m represents 2 can be prepared according to the same methods from starting materials of the general formula K
  • Figure US20080153843A1-20080626-C00050
  • The synthesis preferably begins at the stage of the starting materials Ga.
  • Figure US20080153843A1-20080626-C00051
    • Process for the Preparation of Compounds of the General Formula Jc
  • Figure US20080153843A1-20080626-C00052
  • Compounds of the general formula Ja can be prepared, as described in method 1 and 2, from commercially available amino alcohols which are used as the structural units B and are finally reacted, in the last step, in an amide formation, with tert-butyl piperazine-1-carboxylate and are converted into the products of the general structure Jb under acid conditions, in the presence of, for example, trifluoroacetic acid, hydrogen chloride or chlorotrimethylsilane/water in an organic solvent, such as ethyl acetate, methanol, diethyl ether, methyl ethyl ketone or 1,4-dioxane or those solvents in the form of mixtures, in a temperature range of from 0° C. to +100° C., preferably at from +25° C. to +80° C. The amines or the corresponding hydrochlorides of the general formula Jb can be converted into compounds of the general formula Jc using aldehydes or ketones in a reductive amination, optionally in the presence of an organic base, such as triethylamine or diisopropylethylamine, and in the presence of a suitable reducing agent, for example sodium triacetoxyborohydride, sodium cyanoborohydride or sodium diacetoxyborohydride, or those or similar reducing agents in the form of polymer-bonded variants, optionally in the presence of acetic acid, in an organic solvent, for example tetrahydrofuran, dichloromethane, 1,2-dichloroethane or those solvents in the form of mixtures, in a temperature range of from −0° C. to +25° C.
    • Process for the Preparation of Compounds of the General Formula Je
  • Figure US20080153843A1-20080626-C00053
  • Compounds of the general formula Jd can be prepared, as described in method 1 and 2, from commercially available amino alcohols which are used as structural units B and are finally reacted, in the last step, in an amide formation, with piperidin-4-one. The ketones of the general formula Jd can be converted into compounds of the general formula Je using amines in a reductive amination, optionally in the presence of an organic base, such as triethylamine or diisopropylethylamine, and in the presence of a suitable reducing agent, for example sodium triacetoxyborohydride, sodium cyanoborohydride or sodium diacetoxy-borohydride, or those or similar reducing agents in the form of polymer-bonded variants, optionally in the presence of acetic acid, in an organic solvent, for example tetrahydrofuran, dichloromethane, 1,2-dichloroethane or those solvents in the form of mixtures, in a temperature range of from −0° C. to +25° C.
    • Process for the Preparation of Compounds of the General Formula Jk
  • Figure US20080153843A1-20080626-C00054
  • The commercially available, protected amino alcohols of the general formula Jf can be converted into the products of the general structure Jg in an alkylation reaction with halogenated ester derivatives using tetrabutylammonium chloride or bromide or tetra-butylammonium hydrogen sulfate in a phase-transfer reaction using an organic solvent, such as toluene, benzene or xylene, and an inorganic base, such as potassium hydroxide, sodium hydroxide, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, or in the presence of an organic or inorganic base, conventional inorganic bases are metal alcoholates, such as sodium methanolate, sodium ethanolate, potassium tert-butoxide, lithium or sodium bases, such as lithium diisopropylamide, butyllithium, tert-butyllithium, sodium methoxide, or metal hydrides, such as potassium hydride, lithium hydride, sodium hydride; conventional organic bases are diisopropylethylamine, triethylamine, in an organic solvent, such as dichloromethane, THF or diethyl ether, in a temperature range of from −20° C. to +25° C., preferably at from 0° C. to +25° C., which products of the general structure Jg, in an ester cleavage using organic acids, such as trifluoroacetic acid, or aqueous inorganic acids, such as hydrochloric acid, or using aqueous inorganic bases, such as lithium hydroxide, potassium hydroxide, sodium hydroxide, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, in organic solvents, such as methanol, dioxane, dichloromethane, THF, diethyl ether or those solvents in the form of mixtures, in a temperature range of from 0° C. to +110° C., preferably at from +25° C. to +90° C., yield the acid stages of the general formula Jh. The carboxylic acids Jh can be converted into the products of the general formula Jl, in an amide formation using primary or secondary amines, in the presence of water-removing agents, such as sodium or magnesium sulfate, phosphorus oxide or reagents such as, for example, CDI, DCC, TBTU, EDCI or benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP), also in the presence of HOAt or HOBt and an organic base, for example DIPEA, pyridine or 4-methylmorpholine, in an organic solvent, such as THF, dichloromethane, diethyl ether, dioxane, DMF or acetonitrile, at from 0° C. to +40° C., preferably at room temperature. The compounds Jl can be deprotected in the presence of an inorganic or organic acid, such as HCl, trifluoroacetic acid or formic acid, in an organic solvent, such as THF, dichloro-methane, diethyl ether, dioxane, MeOH or chloroform, at from 0° C. to +40° C., preferably at from +25 to +40° C., to form the products of the general formula Jj. The amines Jj are converted into the sulfonamides Jk in a sulfonylation using sulfonyl chlorides, bromides or pentafluorophenolates R1SO2X (X═Br, Cl or OPFP) in the presence of an organic or inorganic base, for example potassium carbonate, sodium hydrogen carbonate, diisopropylethylamine, triethylamine, pyridine, diethylamine, 1,8-diazabicyclo[5.4.0]-undec-7-ene (DBU) and/or dimethylaminopyridine, or in the presence of tetra-n-butylammonium chloride and in an organic solvent, for example acetonitrile, dichloromethane, THF or N,N-dimethylformamide, in a temperature range of from 0° C. to 120° C., preferably at from +25° C. to +70° C.
  • The separation of diastereoisomers and/or enantiomers is carried out according to methods known to the person skilled in the art, for example by recrystallization, chromatography or, in particular, HPLC chromatography or crystallization using an optionally chiral acid or base and with separation of the salts, or chiral HPLC chromatography (Fogassy et al., Optical resolution methods, Org. Biomol. Chem. 2006, 4, 3011-3030).
    • EXAMPLES
  • In the following examples the yields of the prepared compounds are not optimized, and all temperatures are uncorrected. The term “ether” means diethyl ether, “EE” means ethyl acetate, “DCM” means dichloromethane, “DMF” means dimethylformamide, “DME” means dimethoxyethane, “DMSO” means dimethyl sulfoxide and “THF” means tetrahydrofuran. The term “equivalents” means equivalent amounts, “m.p.” means melting point or melting range, “decomp.” means decomposition, “RT” means room temperature, “abs.” means absolute (anhydrous), “rac.” means racemic, “conc.” means concentrated, “min.” means minutes, “h” means hours, “d” means days, “vol. %” means percent by volume, “wt. %” means percent by weight, and “M” is the concentration in mol/l. The chemicals and solvents used were obtained commercially from the conventional suppliers (ABCR, Acros, Acocado, Aldrich, ApolloScientific, Bachem, Bionet, Chempur, Fluka, Lancaster, Maybridge, Merck, Sigma, TCi TygerScientific, etc.) or were synthesized. Silica gel 60 (0.040-0.063 mm) from E. Merck, Darmstadt was used as the stationary phase for the column chromatography. Thin-layer chromatographic investigations were carried out using precoated HPTLC plates, silica gel 60 F 254, from E. Merck, Darmstadt. The mixing ratios of eluants for chromatographic investigations are always given as volume/volume. Analysis was carried out by means of HPLC-MS, precursors were confirmed by NMR. Other abbreviations used in the examples include:
  • TBTU=O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate,
  • CDI=1,1′-carbonyldiimidazole,
  • DCC=dicyclohexylcarbodiimide,
  • EDCI=1-ethyl-3-(3-dimethylaminopropyl)carbodiimide,
  • HOAt 1-hydroxy-7-azabenzotriazole,
  • DIPEA=N,N-diisopropylamine,
  • HOBt=1-hydroxybenzotriazole, and
  • PFP=pentafluorophenyl.
    • Preparation of the Acid Structural Units:
  • Figure US20080153843A1-20080626-C00055
    • Method 1
  • 1. LiAlH4 (100 ml, 1.0 M in diethyl ether) was added successively with stirring, at a temperature of from −10° C. to RT, under an inert gas atmosphere, to a suspension of the cyclic amino acid (100 mmol) in THF (150 ml). The reaction mixture was stirred for 16 h and thereby warmed to RT. It was then cooled to 0° C. again, and ethyl acetate (20 ml), water (8 ml), 15% aqueous NaOH (8 ml) and water (20 ml) were added, with stirring. After filtration, the residue was washed with diethyl ether. The solvent from the combined organic phases was removed in vacuo, and the product was used in the next step without being purified further.
    2. Et3N (125 mmol) was added to a solution of the amino alcohol (100 mmol) in CH2Cl2 (200 ml), and the mixture was cooled to 0° C. using an ice-bath. The particular sulfonyl chloride (50 mmol), undiluted or in the form of a solution in CH2Cl2 (100 ml), was then added, and stirring was carried out for 3 h at RT. After addition of 0.5 M hydrochloric acid (100 ml), the organic phase was separated off, washed with water, dried over Na2SO4 and filtered, and the solvent was removed in vacuo. The crude product was used in the next step without being purified further or was purified by column chromatography.
    3. n-Bu4NCl (10 mmol) was added to a solution of the product from step 2 (31 mmol) in toluene (200 ml); the mixture was cooled to 0° C., and first aqueous 35% NaOH (200 ml) and then bromoacetic acid tert-butyl ester (46 mmol) were added dropwise. The reaction mixture was stirred for 3 h and then washed with water until neutral and dried over Na2SO4, and the organic solvent was removed in vacuo. The crude product was used in the next step without being purified further or was purified by column chromatography.
    4. The product from step 3 (30 mmol) was dissolved in CH2Cl2 (200 ml); TFA (30 ml) was added, and stirring was carried out for 2 h at RT. The solvent was largely removed in vacuo, and the crude product was purified by recrystallization or chromatography.
  • Figure US20080153843A1-20080626-C00056
    • Method 2
  • 1. A solution of the amino acid (153 mmol) in methanol (500 ml) was cooled to 0° C., and thionyl chloride (168 mmol, 12 ml) was added dropwise. After warming to RT, the reaction solution was heated overnight at 40° C. Removal of the solvent by distillation yielded the crude product, which was used in the next step without being purified further.
    2. Pyridine (459 mmol) and a solution of the sulfonyl chloride (153 mmol) in CH2Cl2 (100 ml) were added to a solution of the methyl ester from step 1 (152 mmol) in CH2Cl2 (400 ml). The reaction solution was stirred overnight at RT. The solution was diluted with a small amount of CH2Cl2 and washed, in succession, with 0.5 M KHSO4, saturated aqueous NaHCO3 solution and saturated aqueous NaCl solution. The organic phase was separated off and dried over Na2SO4, the solvent was removed in vacuo, and the crude product was purified by means of column chromatography.
    3. 4 M NaOH (153 ml, 610 mmol, 4.5 equivalents) was added, with stirring, to a solution of the product from step 2 (136 mmol) in a methanol/dioxane/4 M NaOH mixture in a ratio of 15/4/1 (1020 ml, 203 mmol NaOH, 1.5 equivalents), and stirring was carried out overnight at RT. The solvent was removed in vacuo. The residue was dissolved with ethyl acetate and washed with 0.5 M KHSO4. The organic phase was washed with saturated aqueous NaCl solution, and the separated organic phase, after filtration, was dried over Na2SO4. After removal of the solvent in vacuo and washing with diethyl ether, the purified product from step 3 was obtained.
    4. BH3×DMS (2.0 M in THF, 31.2 ml, 63 mmol) was slowly added dropwise at 0° C., with stirring, to a solution of the product from step 3 (31 mmol) in THF (250 ml). After stirring for 30 minutes at RT, the solution was allowed to warm slowly to RT overnight. Methanol was then added slowly until no more gas was liberated, and the solvent was reduced in vacuo. The crude product was filtered over silica and washed with CH2Cl2/methanol in a ratio of 9/1.
    5. n-Bu4NCl (10 mmol, 2.9 g) was added to a solution of the product from step 4 (31 mmol) in toluene (175 ml), and the mixture was cooled to 0° C.; aqueous 35% NaOH (200 ml) was added first, and then bromoacetic acid tert-butyl ester (48 mmol, 7 ml) was added dropwise. The reaction mixture was stirred for 3 hours and then washed with water until neutral and dried over Na2SO4, and the organic solvent was removed in vacuo. The crude product was used in the next step without being purified further.
    6. The product from step 5 (30 mmol) was dissolved in a mixture of MeOH/dioxane/4 M NaOH in a ratio of 15/4/1 (236 ml, 47 mmol NaOH); further NaOH (4 M, 35 ml, 141 mmol) was added, and stirring was carried out overnight at RT. The solvent was reduced in vacuo, and the residue was diluted with ethyl acetate and washed with 0.5 M KHSO4. The organic phase was separated off, washed with saturated aqueous NaCl solution and dried over Na2SO4. After filtration, the solvent was removed in vacuo. The crude product was purified by coevaporation with diethyl ether and CH2Cl2.
    • Method 3
  • 1. K2CO3 (148 mmol) and the sulfonyl chloride (82 mmol) were added at RT to a solution or suspension of the amino alcohol (74 mmol) in acetone (350 ml), and stirring was carried out overnight at 40-50° C. The reaction mixture was cooled to RT and filtered. The solvent of the filtrate was then removed in vacuo. The crude product was used in the next step without being purified further.
    2. n-Bu4NCl (10 mmol) was added to a solution of the product from step 1 (31 mmol) in toluene (200 ml); the mixture was cooled to 0° C., and first aqueous 35% NaOH (200 ml) and then bromoacetic acid tert-butyl ester (46 mmol) were added dropwise. The reaction mixture was stirred for 3 h and then washed with water until neutral and dried over Na2SO4, and the organic solvent was removed in vacuo. The crude product was used in the next step without being purified further or was purified by column chromatography.
    • Methods of Ester Cleavage
  • a. 6 M NaOH (200 ml, 1200 mmol) was added to a solution of the tert-butyl ester (63 mmol) in THF (200 ml) and methanol (200 ml). The reaction mixture was stirred at RT. After 15 min. to 1 h, the organic solvent was removed, the residue was cooled to 0° C., and 6 M HCl (210 ml) was added. The aqueous phase was extracted with CH2Cl2 (200 ml) and ethyl acetate (200 ml). The combined organic phases were dried over Na2SO4. After filtration, the solvent was removed in vacuo and the residue was coevaporated twice with i-propyl ether.
    b. Dioxane (30 ml) was added to a suspension of the tert-butyl ester (38 mmol) in 6 M NaOH (64 ml, 384 mmol) and methanol (64 ml) until a solution was obtained. The reaction solution was stirred at RT. After 15 min. to 3 h, the organic solvent was removed, the residue was cooled to 0° C., and 6 M HCl (200 ml) was added. The aqueous phase was extracted with CH2Cl2 (200 ml). The combined organic phases were dried over Na2SO4. After filtration, the solvent was removed in vacuo and the residue was coevaporated twice with i-propyl ether.
    c) The tert-butyl ester (7 mmol) was stirred overnight at RT in 4 M HCl in dioxane (7 ml, 27 mmol). After removal of the solvent, the residue was coevaporated twice with i-propyl ether.
  • Figure US20080153843A1-20080626-C00057
    • Preparation of 2-((1-(2,6-dichloro-4-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)-methoxy)acetic acid S24
  • 1. Et3N (95 mmol) was added to a suspension of DL-piperidine-2-carboxylic acid ethyl ester (38 mmol) in CH2Cl2 (150 ml). The solution was cooled to 0° C., the sulfonyl chloride (42 mmol) in a solution of CH2Cl2 (30 ml) was slowly added dropwise, and stirring was carried out for 2 h at RT. The organic phase was extracted with 1 M HCl (250 ml) and H2O (250 ml). The organic phase was separated off and dried over Na2SO4. The solvent was removed in vacuo. The residue was coevaporated with i-propyl ether and the product was used in the next step without being purified further.
    2. 4 M NaOH (113 mmol) was added at RT, with stirring, to a solution of the ester (38 mmol) in a solvent mixture of methanol/dioxane/4 M NaOH (15/4/1) (57 mmol NaOH), and stirring was carried out for 2 h. The organic solvent was removed in vacuo, and the residue was diluted with ethyl acetate (300 ml) and extracted with 1 M KHSO4 (300 ml). The organic phase was washed with saturated NaCl solution (200 ml). The organic phase was separated off and dried over Na2SO4; filtration was carried out, and the solvent was removed in vacuo. The product was used in the next step without being purified further.
    3. 2 M BH3×DMS in THF (82 mmol) was added slowly at 0° C., with stirring, to a solution of the carboxylic acid (27 mmol) in THF (135 ml). After further cooling for 30 min., stirring was carried out overnight at RT. After removal of the solvent, the crude product was obtained, which was used in the next step without being purified further.
    4. n-Bu4NCl (8.8 mmol) was added to a solution of bromoacetic acid tert-butyl ester (40 mmol) in toluene (100 ml). The reaction mixture was cooled to 0° C., and 35% NaOH (150 ml) and then, dropwise, the alcohol (27 mmol) dissolved in toluene (50 ml) were added. After stirring for 1.5 h at RT, the organic phase was separated off and extracted with water (4×150 ml) and with saturated NaCl solution (150 ml). The organic phase was separated off and dried over Na2SO4; filtration was carried out, and then the solvent was removed in vacuo. The crude product was purified by column chromatography.
    5. The tert-butyl ester (16 mmol) was stirred overnight at RT in 4 M HCl in dioxane (70 ml, 27 mmol). After removal of the solvent, the crude product was purified by column chromatography.
    • Preparation of ((2-(1-(2,6-dichloro-4-(trifluoromethyl)phenylsulfonyl)pyrrolidin-2-yl)-methoxy)acetic acid S23
  • 1. Et3N (181 mmol) was added to a suspension of DL-pyrrolidine-2-carboxylic acid methyl ester hydrochloride (36 mmol) in CH2Cl2 (180 ml). The solution was cooled to 0° C., the sulfonyl chloride (40 mmol) in a solution of CH2Cl2 (30 ml) was slowly added dropwise, and stirring was carried out for 2 h at RT. The organic phase was extracted with 1 M HCl (250 ml), H2O (250 ml). The organic phase was separated off and dried over Na2SO4. The solvent was removed in vacuo. The residue was coevaporated with i-propyl ether and the product was used in the next step without being purified further.
    2. 4 M NaOH (108 mmol) was added at RT, with stirring, to a solution of the ester (36 mmol) in a solvent mixture of methanol/dioxane/4 M NaOH (15/4/1) (54 mmol NaOH), and stirring was carried out for 2 h. The organic solvent was removed in vacuo, and the residue was diluted with ethyl acetate (300 ml) and extracted with 1 M KHSO4 (300 ml). The organic phase was washed with saturated NaCl solution (200 ml). The organic phase was separated off and dried over Na2SO4; filtration was carried out, and the solvent was removed in vacuo. The product was used in the next step without being purified further.
    3. 2 M BH3×DMS in THF (86 mmol) was slowly added at 0° C., with stirring, to a solution of the carboxylic acid (28 mmol) in THF (140 ml). After further cooling for 30 min., stirring was carried out overnight at RT. After removal of the solvent, the crude product was obtained, which was used in the next step without being purified further.
    4. n-Bu4NCl (9 mmol) was added to a solution of bromoacetic acid tert-butyl ester (42 mmol) in toluene (100 ml). The reaction mixture was cooled to 0° C., and 35% NaOH (150 ml) and then, dropwise, the alcohol (28 mmol) dissolved in toluene (50 ml) were added. After stirring for 1.5 h at RT, the organic phase was separated off and extracted with water (4×150 ml) and with saturated NaCl solution (150 ml). The organic phase was separated off and dried over Na2SO4; filtration was carried out, and then the solvent was removed in vacuo. The crude product was purified by column chromatography.
    5. The tert-butyl ester (16 mmol) was stirred overnight at RT in 4 M HCl in dioxane (70 ml, 27 mmol). After removal of the solvent, the crude product was purified by column chromatography.
    • Preparation of 2-((1-(3,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)-methoxy)acetic acid S35
  • Figure US20080153843A1-20080626-C00058
  • 1. 1,2,3,4-tetrahydroquinolin-2-carboxylic acid ethyl ester (25 mmol) in THF (5 ml/mol) was added dropwise at 0° C. to a suspension of LAH (2 eq.) in THF (50 ml). The reaction mixture was stirred for 1 h at RT and then heated under reflux for 4 h. After addition of aqueous saturated Na2SO4 solution, filtration was carried out and the organic solvent was removed in vacuo. The product was purified by column chromatography (3:7 ethyl acetate/hexane). Yield: 50%.
    2. Pyridine (5 eq.), DMAP (0.5 eq.) and 3,4-dichlorobenzenesulfonyl chloride (1.2 eq.) dissolved in CH2Cl2 (50 ml) were added to a suspension, cooled to 0° C., of the alcohol (16 mmol) in CH2Cl2 (5 ml/mmol). After stirring for 5 h at 0° C., CH2Cl2 was added and the mixture was washed with aqueous copper sulfate solution, water and saturated NaCl solution. After drying over sodium sulfate and filtration, the solvent was removed in vacuo. The product was purified by column chromatography (5:95 ethyl acetate/CH2Cl2). Yield: 80%.
    3. A solution of the sulfonamide (16 mmol) dissolved in THF (100 ml) was added dropwise, with stirring, to a suspension, cooled to 0° C., of NaH (2 eq.) in THF (300 ml). After stirring for 45 min. at that temperature, a solution of bromoacetic acid tert-butyl ester (1.5 eq.) in THF (50 ml) was added. The reaction mixture was heated for 20 h at 50° C. It was then cooled to 0° C., ice was added, and extraction with ethyl acetate was carried out. The organic phase was washed with aqueous saturated NaCl solution and dried over Na2SO4. After filtration, the solvent was removed in vacuo. The product was purified by column chromatography (1:9 ethyl acetate/hexane). Yield: 50%.
    4. TFA (13 eq.) was added at a temperature of 0° C., with stirring, to a solution of the tert-butyl ester (1 eq.) in CH2Cl2 (10 ml/mmol). After stirring for 3 h at 0° C., the solvent was removed in vacuo. The crude product was used without being worked up further.
    • Preparation of 4-methoxy-2,6-dimethoxybenzene-1-sulfonyl chloride
  • Figure US20080153843A1-20080626-C00059
  • Chlorosulfonic acid (251 ml, 3763 mmol) in CH2Cl2 (250 ml) was added dropwise to a solution of 3,5-dimethylanisole (102.5 g, 753 mmol) in CH2Cl2 (1 l), cooled to 0° C. After 10 min., the reaction mixture was poured onto ice (1 l) and extracted with CH2Cl2 (1×250 ml). The organic phase was washed with water (1 l) and with aqueous saturated NaCl solution (1 l). After drying over Na2SO4 and filtration, the solvent was removed in vacuo. The product was purified by column chromatography (silica, heptane/CH2Cl2, 5:1). Yield: 63.5 g, 36%.
  • The following structural units were prepared according to these methods:
  • Structural
    unit Structure Synthesis method
    S1
    Figure US20080153843A1-20080626-C00060
         		1
    S2
    Figure US20080153843A1-20080626-C00061
         		1
    S3
    Figure US20080153843A1-20080626-C00062
         		1
    S4
    Figure US20080153843A1-20080626-C00063
         		1
    S5
    Figure US20080153843A1-20080626-C00064
         		1
    S6
    Figure US20080153843A1-20080626-C00065
         		1
    S7
    Figure US20080153843A1-20080626-C00066
         		1
    S8
    Figure US20080153843A1-20080626-C00067
         		1
    S9
    Figure US20080153843A1-20080626-C00068
         		1
    S10
    Figure US20080153843A1-20080626-C00069
         		1
    S11
    Figure US20080153843A1-20080626-C00070
         		1
    S12
    Figure US20080153843A1-20080626-C00071
         		1
    S13
    Figure US20080153843A1-20080626-C00072
         		1
    S14
    Figure US20080153843A1-20080626-C00073
         		1
    S15
    Figure US20080153843A1-20080626-C00074
         		1
    S16
    Figure US20080153843A1-20080626-C00075
         		2
    S17
    Figure US20080153843A1-20080626-C00076
         		1
    S18
    Figure US20080153843A1-20080626-C00077
         		1
    S19
    Figure US20080153843A1-20080626-C00078
         		1b
    S20
    Figure US20080153843A1-20080626-C00079
         		1c
    S21
    Figure US20080153843A1-20080626-C00080
         		1c
    S22
    Figure US20080153843A1-20080626-C00081
         		1
    S23
    Figure US20080153843A1-20080626-C00082
         		—
    S24
    Figure US20080153843A1-20080626-C00083
         		—
    S25
    Figure US20080153843A1-20080626-C00084
         		1b
    S26
    Figure US20080153843A1-20080626-C00085
         		1c
    S27
    Figure US20080153843A1-20080626-C00086
         		3a
    S28
    Figure US20080153843A1-20080626-C00087
         		1
    S29
    Figure US20080153843A1-20080626-C00088
         		3a
    S30
    Figure US20080153843A1-20080626-C00089
         		1
    S31
    Figure US20080153843A1-20080626-C00090
         		3b
    S32
    Figure US20080153843A1-20080626-C00091
         		3a
    S33
    Figure US20080153843A1-20080626-C00092
         		3a
    S34
    Figure US20080153843A1-20080626-C00093
         		3a
    S35
    Figure US20080153843A1-20080626-C00094
         		—

    S18 was prepared from structural unit
  • Figure US20080153843A1-20080626-C00095
  • according to method 1.
  • The amines used were commercially available or were prepared according to methods known to the person skilled in the art or as described below. The following amine structural units were used for the syntheses:
    • Preparation of Amine Structural Units A1-A4
  • Figure US20080153843A1-20080626-C00096
  • 1. 4-bromomethylbenzonitrile (500 mg, 2.55 mmol), K2CO3 (388 mg, 2.8 mmol), amine (2.8 mmol) and DMF (6 ml) were stirred for 0.5 to 3 h at RT and then heated for 2 to 6 h at 80-90° C. The reaction mixture was cooled to RT, water (18 ml) was added, and stirring was carried out for 0.5 h at 0-5° C. The precipitates were filtered off, washed with cold water (2×10 ml) and dried in vacuo. The filtrates were extracted with ethyl acetate (3×15 ml) and dried over Na2SO4. The organic solvent was removed.
    2. A solution of step 1 (1 mmol) dissolved in THF (5 ml) was added dropwise, under a nitrogen atmosphere, to a stirred suspension of LAH (4 mmol) in THF (5 ml). The reaction mixture was stirred at 25° C.; after 16 to 20 h, it was cooled with ice, and aqueous saturated Na2SO4 solution was added dropwise. After filtration and washing the residue with ethyl acetate (3×10 ml), the solvent was largely removed and HCl gas was introduced at 0-5° C. The precipitate was filtered off and washed with ether. The amine hydrochlorides were obtained in the form of products which were used without being worked up further.
    • Preparation of Amine Structural Units A6, A8
  • Figure US20080153843A1-20080626-C00097
  • 1. A reaction mixture of 4-benzonitrile (2 mmol), amine (3 mmol), K2CO3 (4 mmol), CuI (0.2 mmol) and L-proline (0.4 mmol) in DMSO (4 ml) was heated for 40 h at 80-90° C., with stirring. After addition of water, extraction with ethyl acetate was carried out. The organic phase was washed with aqueous saturated NaCl solution and dried over Na2SO4. After filtration and removal of the solvent, the residue was purified by column chromatography (30% ethyl acetate/CH2Cl2).
    2. A solution of step 1 (1 mmol) dissolved in THF (5 ml) was added dropwise, under a nitrogen atmosphere, to a stirred suspension of LAH (4 mmol) in THF (5 ml). The reaction mixture was heated under reflux for 6 h and cooled with ice, and aqueous saturated Na2SO4 solution was added dropwise. After filtration, the residue was washed with a solvent mixture (ethyl acetate and 10% methanol, 3×10 ml). After removal of the solvent, the amines were obtained, which were used without being worked up further.
    • Preparation of 4-(aminomethyl)-N,N-dimethylaniline A5
  • Figure US20080153843A1-20080626-C00098
  • 1. Me2SO4 (1.01 ml, 10.57 mmol) was added dropwise at 0° C. to a stirred suspension of 4-aminobenzonitrile (0.5 g, 4.23-mmol) in 10% aqueous Na2CO3 solution (18 ml). The reaction mixture was stirred for 1 h at 25° C. Further Me2SO4 (1.01 ml, 10.57 mmol) and 10% aqueous Na2CO3 solution (18 ml) were then added. After addition of water, extraction with ethyl acetate was carried out. The organic phase was separated off, washed with aqueous saturated NaCl solution and dried over Na2SO4. After filtration and removal of the solvent, the residue was purified by column chromatography (5% ethyl acetate/hexane).
    2. A solution of step 1 (1 mmol) dissolved in THF (5 ml) was added dropwise, under a nitrogen atmosphere, to a stirred suspension of LAH (4 mmol) in THF (5 ml). The reaction mixture was heated under reflux for 6 h and cooled with ice, and aqueous saturated Na2SO4 solution was added dropwise. After filtration, the residue was washed with a solvent mixture (ethyl acetate and 10% methanol, 3×10 ml). The solvent was largely removed in vacuo and the amine was obtained in the form of the hydrochloride by introduction of HCl gas.
    • Preparation of (4-morpholinophenyl)methanamine A7
  • Figure US20080153843A1-20080626-C00099
  • 1. A reaction mixture of 4-morpholinebenzoic acid (0.5 g) and methanolic HCl solution (6 ml, 4%) was heated under reflux for 6 h, with stirring. After removal of the solvent in vacuo, water (10 ml) was added to the residue and the mixture was neutralized with aqueous saturated NaHCO3 solution. The solution was extracted with ethyl acetate (3×20 ml). The organic phase was separated off and dried over Na2SO4. After filtration and removal of the solvent, the product was obtained, which was used in the next step without being worked up further.
    2. A reaction mixture of product step 1 (4 g), NH3 (25 ml) and methanol (20 ml) was heated for 4 d at 120° C. in an autoclave (pressure 50 kg/cm2). After removal of the solvent in vacuo, the product was purified by column chromatography (50% ethyl acetate/hexane).
    3. BH3×DMS (1.86 ml, 19.4 mmol) was added at 0° C., with stirring, under a nitrogen atmosphere, to a solution of the amide from step 2 (1 g, 4.84 mmol) in THF (15 ml). The reaction mixture was heated under reflux for 18 h and cooled, and methanol was added. The solvent was removed in vacuo, and the residue was dissolved in ethyl acetate and washed with aqueous saturated NaCl solution. After filtration and drying over Na2SO4, the solvent was removed in vacuo and the product was used in the next step without being worked up further.
    4. (Boc)2O (0.82 ml, 3.83 mmol) was added to a solution of the amine from step 3 (0.67 g) dissolved in THF (12 ml), and stirring was carried out for 18 h. The solvent was then removed in vacuo and the product was purified by column chromatography (10% ethyl acetate/hexane).
    5. A solution of HCl gas in ethyl acetate (4%) was added to the Boc-protected product from step 4 (280 mg), and stirring was carried out for 2 h at RT. The solvent was removed in vacuo and the residue was taken up in a small amount of ethyl acetate. After filtration and drying in vacuo, the product was obtained in the form of the amine hydrochloride.
    • Preparation of N,N-dimethyl-4-(2-(methylamino)ethyl)cyclohexanamine A9 and N-methyl-2-(4-(pyrrolidin-1-yl)cyclohexyl)ethanamine A10
  • Figure US20080153843A1-20080626-C00100
  • 1. A solution of triethyl phosphonoacetate (11 mmol) in THF (50 ml) was added slowly to a suspension, cooled to 0° C., of NaH (10 mmol) in THF (50 ml), and the reaction mixture was stirred for 30 min. 1,4-Dioxa-spiro[4.5]decan-8-one (10 mmol) in THF (50 ml) was then added dropwise at 0° C., and stirring was carried out for 16 h. After addition of ice and aqueous saturated NaCl solution, the aqueous phase was washed with ethyl acetate and the organic phase with water and aqueous saturated NaCl solution. The combined organic phases were dried over Na2SO4 and, after filtration, the solvent was removed in vacuo. The product was purified by column chromatography (20% ethyl acetate/hexane). Yield: 90%.
    2. A solution of the ester (10 mmol) in MeOH (30 ml) was hydrogenated with hydrogen for 16 h under argon with 10% Pd/C (50%). After filtration over Celite, the residue was washed with MeOH and the solvent of the combined organic phases was removed in vacuo. The product was used in the next step without being worked up further.
    3. A solution of (1,4-dioxa-spiro[4.5]dec-8-yl)acetic acid ethyl ester (10 mmol) in THF (50 ml) was slowly added over a period of 30 min. to a suspension, cooled to 0° C., of LaH (10 mmol) in THF (30 ml). When the reaction of the ester was complete, the solution was cooled to 0° C., aqueous saturated Na2SO4 solution was added, and filtration over Celite was carried out. The solvent was removed in vacuo and the product was used in the next step without being worked up further.
    4. Methanesulfonyl chloride (11 mmol) was added dropwise at 0° C., under nitrogen, to a solution of the alcohol (10 mmol) in CH2Cl2 (50 ml). The reaction mixture was stirred for a further 2 h and then diluted with CH2Cl2. After extraction with aqueous saturated NaCl solution, drying over Na2SO4 was carried out. After filtration and removal of the solvent, the crude product was obtained in a yield of 80%.
    5. A 2 M solution of methylamine in CH2Cl2 (10 ml) was added to a solution of the Ms-protected alcohol (5 mmol) in THF (5 ml), and the reaction solution was heated for 16 h at 100° C. After removal of the solvent in vacuo, the crude product was used in the next step without being worked up further. Yield of crude product: 90%.
    6. 6 N HCl (20 ml) was added at 0° C. to [2-(1,4-dioxa-spiro[4.5]dec-8-yl)-ethyl]-methylamine (10 mmol), and stirring was carried out for 16 h at 25° C. The aqueous solution was extracted with ethyl acetate and then adjusted to pH 14 with 6N NaOH. The aqueous phase was extracted with CH2Cl2 and the organic phase was washed with water and aqueous saturated NaCl solution. The organic phase was dried over Na2SO4 and, after filtration, the solvent was removed. The crude product was used in the next step without being worked up further. Yield of crude product: 80%.
    7. Diisopropylamine (37.5 mmol) and di-tert-arylbutyl dicarbonate (22.5 mmol) were added at 0° C. to a solution of 4-(2-methylamino-ethyl)-cyclohexanone (15 mmol) in CH2Cl2 (45 ml). The reaction mixture was stirred for 16 h at 25° C. After addition of CH2Cl2, extraction with water and aqueous saturated NaCl solution was carried out. The organic phase was separated off and dried over Na2SO4. After filtration, the solvent was removed in vacuo and the product was purified by column chromatography (5% methanol/CH2Cl2). Yield: 70%.
    8. To a solution of the ketone (1 eq.) in methanol (10 ml/mmol) there were added the corresponding amine (1.5 eq.), sodium cyanoborohydride (2 eq.) and acetic acid (2 eq.). The reaction mixture was stirred for 16 h at 25° C. Ice was then added thereto, and the solvent was removed in vacuo. After addition of ethyl acetate, extraction was carried out first with aqueous saturated Na2CO3 solution and then with aqueous saturated NaCl solution. The organic phase was separated off, dried over Na2SO4 and filtered, and the solvent was removed in vacuo. The product was purified by column chromatography (3% methanol/CH2Cl2).
    9. 20% TFA in CH2Cl2 (5 ml/mmol) was added at 0° C. to the Boc-protected precursor, and the reaction mixture was stirred for 3 h. The solvent was removed in vacuo and the amine was used in the form of the TFA salt in the further synthesis.
    • Amine Structural Units:
  • Structural Synthesis
    unit Structure method
    A1
    Figure US20080153843A1-20080626-C00101
         		1
    A2
    Figure US20080153843A1-20080626-C00102
         		1
    A3
    Figure US20080153843A1-20080626-C00103
         		1
    A4
    Figure US20080153843A1-20080626-C00104
         		1
    A5
    Figure US20080153843A1-20080626-C00105
         		—
    A6
    Figure US20080153843A1-20080626-C00106
         		2
    A7
    Figure US20080153843A1-20080626-C00107
         		—
    A8
    Figure US20080153843A1-20080626-C00108
         		2
    A9
    Figure US20080153843A1-20080626-C00109
         		—
    A10
    Figure US20080153843A1-20080626-C00110
         		—
    • Preparation of the Compounds of the Examples by Amide Formation in Parallel Synthesis:
  • Figure US20080153843A1-20080626-C00111
    • Parallel Synthesis Method 1
  • Acid solution (0.05 M in CH2Cl2, 2 ml) was added to 105 μmol of CDI solution (0.105 M in CH2Cl2, 1 ml), and the mixture was agitated for 1 h at RT. 100 μmol of the amine solution (0.1 M in CH2Cl2) were then added at RT, and the mixture was agitated for a further 12 h at RT. 3 ml of water were then added to the reaction mixture, agitation was carried out for 15 min., and the organic phase was separated off. After removal of the solvent by distillation, the crude products were analysed by LC-MS and purified by HPLC.
    • Parallel Synthesis Method 2
  • At RT, 100 μmol of acid solution (0.05 M in CH2Cl2, 2 ml) were placed in a vessel, and 105 μmol of CDI solution (0.105 M in CH2Cl2, 1 ml) were added. After stirring for 1 h at RT, 100 μmol of the corresponding amine (0.1 M in CH2Cl2) were pipetted into the reaction solution. The reaction solution was stirred for 16 h at RT. 3 ml of water were then added, and vortexing and thorough mixing were carried out for 30 min. The magnetic stirrer bar was filtered off, and the vessel was flushed with 1.5 ml of CH2Cl2.
  • The aqueous phase was removed and discarded. 3 ml of H2O and 0.5 ml of CH2Cl2 were added to the organic phase; vortexing was carried out, followed by intensive mixing for 15 min. After centrifugation, the aqueous phase was separated off and discarded. The organic phase was extracted in an analogous manner for a second time with 3 ml of saturated NaCl solution. The organic phase was then removed, introduced into a test glass and dried over a MgSO4 cartridge. After removal of the solvent by distillation, the crude products were analysed by means of LC-MS and purified by HPLC.
    • Parallel Synthesis Method 3
  • The acids (50 mg, 1 eq.) were reacted with the amine (50-70 mg, 1.2 eq.) in CH2Cl2 (3 ml/mmol) using the coupling reagents EDCI (1.5 eq.), HOBt (1 eq.) and DIPEA (2 eq.). After removal of the solvent, the products were purified by column chromatography.
    • Parallel Synthesis Method 4
  • The acids (50 mg, 1 eq.) in CH2Cl2 (3 ml/mmol) were stirred for 15 min. at 25° C. with EDCI (1.5 eq.), HOBt (1 eq.) and DIPEA (1.5 eq.). DIPEA (4 eq.) was added at 0° C. to a solution of the amine-TFA salt (1.2 eq.) in CH2Cl2 (1 ml/mmol), and the whole was added to the solution of the acid. The reaction mixture was stirred for 16 h at 25° C. and then diluted with CH2Cl2. The organic phase was separated off, extracted with aqueous NH4Cl solution, Na2CO3 solution, NaCl solution and then dried over Na2SO4. After filtration and removal of the solvent, the products were purified by column chromatography.
  • The following compounds were prepared according to one of these methods of parallel synthesis.
  • Example Method Mass
    1 1 543.28
    2 1 557.29
    3 1 558.29
    4 1 601.13
    5 2 568.31
    6 1 535.25
    7 1 572.30
    9 2 579.17
    10 1 587.12
    11 1 517.26
    12 1 541.30
    13 1 602.13
    14 1 543.28
    15 1 616.14
    16 2 601.16
    17 1 565.16
    18 1 544.27
    19 1 491.28
    20 1 559.20
    21 1 545.26
    22 2 546.25
    23 2 499.25
    24 1 559.27
    25 2 556.31
    26 1 517.16
    27 2 505.30
    28 1 546.18
    29 1 588.11
    30 1 603.11
    31 2 527.28
    32 1 546.18
    33 2 590.29
    34 1 549.27
    35 1 503.25
    36 1 545.19
    37 1 561.10
    38 1 565.16
    39 1 583.13
    40 1 558.29
    41 2 589.30
    42 1 560.20
    43 1 626.25
    44 1 569.12
    45 1 602.13
    46 1 507.14
    47 1 565.26
    48 2 600.37
    49 1 589.10
    50 2 577.26
    51 1 579.17
    52 1 521.29
    53 1 555.14
    54 1 531.17
    55 1 545.26
    56 1 525.13
    57 1 538.15
    58 2 534.25
    59 1 543.12
    60 1 529.26
    61 1 551.25
    62 1 532.17
    63 1 563.28
    64 1 513.27
    65 2 581.15
    66 1 459.22
    67 2 575.28
    68 1 545.19
    69 1 569.29
    70 1 567.17
    71 1 573.10
    72 1 546.18
    73 1 547.09
    74 1 587.12
    75 2 590.29
    76 1 527.28
    77 2 529.26
    78 1 601.16
    79 1 601.16
    80 1 542.29
    81 2 587.14
    82 1 579.17
    83 2 575.28
    84 1 555.14
    85 1 534.18
    86 1 543.12
    87 1 510.23
    88 1 520.17
    89 1 511.11
    90 2 535.30
    91 2 529.26
    194 4 563.3
    209 4 537.3
    213 4 595.2
    216 4 621.2
    218 2 553.2
    219 1 515.3
    220 1 598.2
    221 1 536.3
    222 2 552.3
    223 2 589.3
    224 2 603.1
    225 2 505.3
    226 2 499.3
    227 2 529.3
    228 2 541.3
    229 2 527.3
    230 2 528.3
    231 2 520.3
    232 2 534.3
    233 2 594.2
    234 2 596.3
    235 2 513.3
    236 2 501.2
    237 2 501.2
    238 2 501.2
    239 2 489.2
    240 2 535.3
    241 2 557.3
    242 2 453.2
    243 2 513.2
    244 2 511.2
    245 2 543.3
    246 2 529.3
    247 2 501.2
    248 2 496.3
    249 2 627.3
    250 2 483.3
    251 2 593.2
    252 2 573.3
    253 2 619.1
    254 2 610.2
    255 2 627.2
    256 2 604.1
    257 2 463.2
    258 2 496.2
    259 2 440.2
    260 2 522.3
    261 2 516.3
    262 2 542.3
    263 2 571.3
    264 2 521.2
    265 2 589.1
    266 1 547.2
    267 2 522.3
    268 2 535.3
    269 2 546.3
    270 2 552.3
    271 2 487.2
    272 2 487.2
    273 2 487.2
    274 2 502.2
    275 2 598.3
    276 2 611.3
    277 2 605.3
    278 2 546.2
    279 2 559.2
    280 2 570.2
    281 2 576.2
    282 2 511.1
    283 2 526.1
    284 2 553.2
    285 2 532.2
    286 2 545.2
    287 2 556.2
    288 2 545.3
    289 2 533.2
    290 2 545.3
    291 2 481.3
    292 2 568.3
    293 1 539.1
    294 2 613.3
    295 2 497.1
    296 2 537.1
    297 2 553.1
    298 2 551.1
    299 2 529.3
    300 2 543.3
    301 2 530.3
    302 2 544.3
    303 2 529.3
    304 2 559.3
    305 2 502.2
    306 2 531.2
    307 2 519.2
    308 2 531.2
    309 2 503.2
    310 2 529.3
    311 2 549.2
    312 2 527.2
    313 2 553.2
    314 2 567.2
    315 2 553.2
    316 2 526.1
    317 2 555.1
    318 2 543.1
    319 2 555.1
    320 2 553.2
    321 2 573.1
    322 2 539.1
    323 2 553.2
    324 2 541.1
    325 2 541.1
    326 2 539.1
    327 2 587.1
    328 2 575.1
    329 2 573.1
    330 2 566.1
    331 2 579.2
    332 2 590.1
    333 2 596.2
    334 2 613.1
    335 2 546.1
    336 2 531.2
    337 2 517.2
    338 2 511.1
    339 2 497.1
    340 2 575.3
    341 2 566.4
    342 2 583.3
    343 2 467.3
    344 2 497.3
    345 2 461.2
    346 2 535.2
    347 2 529.3
    348 2 569.2
    349 2 583.2
    350 2 593.2
    351 2 557.3
    352 2 549.2
    353 2 529.3
    354 2 545.1
    355 2 539.1
    356 2 579
    357 2 593.1
    358 2 603
    359 2 559.1
    360 2 539.1
    361 2 531.3
    362 2 543.3
    363 2 467.3
    364 2 543.3
    365 2 529.3
    366 2 478.2
    367 2 545.3
    368 2 573.3
    369 2 516.2
    370 2 497.2
    371 2 500.2
    372 2 448.2
    373 2 543.3
    374 2 507.3
    375 2 467.3
    376 2 618.2
    377 2 531.3
    378 2 583.2
    379 2 455.3
    380 2 497.3
    381 2 597.2
    382 2 607.2
    383 2 571.3
    384 2 563.2
    385 2 543.3
    386 2 559.3
    387 2 547.3
    388 2 529.3
    389 2 545.1
    390 2 545.1
    391 2 533.1
    392 2 601.1
    393 2 497.1
    394 2 505
    395 2 532.2
    396 2 532.2
    397 2 568.3
    398 2 543.3
    399 2 521.3
    400 2 571.3
    401 2 572.3
    402 2 598.2
    403 2 553.2
    404 2 593.1
    405 2 607.1
    406 2 617.1
    407 2 573.1
    408 2 553.2
    409 2 515.3
    410 2 492.2
    411 2 586.3
    412 2 524.3
    413 2 495.3
    414 2 543.3
    415 2 557.3
    416 2 478.2
    417 2 604.3
    418 2 543.3
    419 2 543.3
    420 2 526.2
    421 2 557.3
    422 2 563.3
    423 2 549.2
    424 2 531.3
    425 2 476.2
    426 2 478.2
    427 2 526.2
    428 2 543.3
    429 2 529.3
    430 2 543.3
    431 2 544.3
    432 2 558.3
    433 2 558.3
    434 2 558.3
    435 2 545.3
    436 2 531.2
    437 2 545.3
    438 2 531.2
    439 2 545.3
    440 2 591.1
    441 2 593.3
    442 2 543.1
    443 2 517.2
    444 2 533.2
    445 2 515.3
    446 2 572.3
    447 2 501.2
    448 2 515.3
    449 2 515.3
    450 2 543.3
    451 2 555.1
    452 2 506.2
    453 2 525.1
    454 2 557.1
    455 2 539.1
    456 2 525.1
    457 2 553.2
    458 2 539.1
    459 2 511.1
    460 2 515.3
    461 2 501.2
    462 2 559.2
    463 2 537.2
    464 2 537.2
    465 2 569.2
    466 2 475.2
    467 2 453.2
    468 2 570.2
    469 2 604.2
    470 2 589.3
    471 2 528.3
    472 2 574.2
    473 2 543.3
    474 2 553.3
    475 2 557.3
    476 2 453.2
    477 2 528.3
    478 2 531.1
    479 2 577.3
    480 2 539.1
    481 2 593.1
    482 2 499.1
    483 2 477.1
    484 2 594.1
    485 2 528.1
    486 2 547.1
    487 2 577.1
    488 2 552.2
    489 2 541.2
    490 2 529.3
    491 2 531.2
    492 2 521.3
    493 2 550.2
    494 2 485.2
    495 2 570.2
    496 2 596.2
    497 2 511.1
    498 2 555.1
    499 2 545.2
    500 2 544.3
    501 2 485.2
    502 2 562.2
    503 2 561.3
    504 2 486.2
    505 2 529.3
    506 2 502.1
    507 2 551.3
    508 2 551.3
    509 2 583.2
    510 2 489.2
    511 2 549.2
    512 2 543.3
    513 2 541.2
    514 2 584.2
    515 2 567.1
    516 2 519.2
    517 2 453.2
    518 2 493.3
    519 2 509.3
    520 2 507.3
    521 2 572.3
    522 2 481.3
    523 2 481.3
    524 2 536.3
    525 2 526.2
    526 2 572.2
    527 2 536.1
    528 2 553.2
    529 2 553.2
    530 2 555.2
    531 2 541.2
    532 2 495.3
    533 2 549.3
    534 2 551.3
    535 2 450.2
    536 2 512.2
    537 2 546.2
    538 2 572.2
    539 2 518.2
    540 2 542.2
    541 2 542.2
    542 2 530.2
    543 2 542.2
    544 2 526.2
    545 2 512.2
    546 2 497.2
    547 2 555.3
    548 2 566.3
    549 2 569.2
    550 2 593.1
    551 2 594
    552 2 493.1
    553 2 582.1
    554 2 616.1
    555 1 530.3
    556 1 545.2
    557 1 572.3
    558 1 531.2
    559 2 560.3
    560 2 586.3
    561 2 540.3
    562 2 598.3
    563 2 612.3
    564 2 534.2
    565 2 546.2
    566 2 520.2
    567 2 532.2
    568 2 533.2
    569 2 588.2
    570 2 600.2
    571 2 546.3
    572 2 534.3
    573 2 548.3
    574 2 621.1
    575 3 533.1
    576 3 489.2
    577 3 503.3
    578 3 547.1
    579 3 531.2
    580 3 575.1
    581 3 589.1
    • Example 8 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-ethanone
  • Figure US20080153843A1-20080626-C00112
  • N,N′-Carbonyldiimidazole (114 mg, 0.706 mmol) was added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid (250 mg, 0.673 mmol) in dichloromethane (15 ml), and the mixture was stirred for 1 h at room temperature. A solution of 1-(1-methylpiperidin-4-yl)piperazine (123 mg, 0.673 mmol) in dichloromethane (5 ml) was then added, and the reaction mixture was stirred for 15 h at room temperature. The reaction mixture was then extracted with water (20 ml) and saturated sodium chloride solution (20 ml), and the organic phase was dried over magnesium sulfate and concentrated in vacuo. The crude product was purified by flash chromatography using dichloromethane/methanol (97:3→90:10).
  • Yield: 296 mg (82%), brown resin
  • 1H-NMR (600 MHz, DMSO-d6): 1.27 (1H); 1.42 (1H); 1.55 (4H); 1.69 (2H); 1.79 (1H); 1.89 (2H); 2.18 (3H); 2.40 (4H); 2.53 (6H); 2.83 (2H); 2.95 (1H); 3.26 (4H); 3.38 (3H); 3.50 (1H); 3.66 (1H); 3.80 (4H); 4.05 (2H); 6.79 (2H).
    • Preparation of the Hydrochloride: Example 97 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methyl-piperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
  • N,N′-Carbonyldiimidazole (272 mg, 1.696 mmol) was added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid (600 mg, 1.615 mmol) in dichloromethane (15 ml), and the mixture was stirred for 1 h at room temperature. A solution of 1-(1-methylpiperidin-4-yl)piperazine (293 mg, 1.615 mmol) in dichloromethane (5 ml) was then added, and the reaction mixture was stirred for 15 h at room temperature. Saturated sodium hydrogen carbonate solution (20 ml) was then added to the reaction mixture, and then the aqueous phase was extracted with dichloromethane (2×20 ml). The combined organic phases were extracted with saturated sodium chloride solution (20 ml), dried over sodium sulfate and concentrated in vacuo. The crude product was purified by flash chromatography using dichloromethane/methanol (5:1). 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone (590 mg, 1.105 mmol) was dissolved in methyl ethyl ketone/ethanol (1:1) (20 ml) [plus a few drops of acetone], and chlorotrimethylsilane (168 μl, 1.326 mmol) was added slowly. Diethyl ether (20 ml) was then added, and the mixture was stirred for 1 h at 0° C. The resulting precipitate was filtered off, dried with the exclusion of air and washed with diethyl ether.
  • Yield: 430 mg (44%), white solid
  • HPLC-MS, m/z 537.2 (MH+)
    • Example 92 3-((4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)-methoxy)acetyl)piperazin-1-yl)methyl)benzonitrile hydrochloride
  • Figure US20080153843A1-20080626-C00113
  • N,N′-Carbonyldiimidazole (68 mg, 0.424 mmol) was added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid (150 mg, 0.404 mmol) in dichloromethane (4 ml), and the mixture was stirred for 1 h at room temperature. A solution of 3-(piperazin-1-ylmethyl)benzonitrile (81 mg, 0.404 mmol) in dichloromethane (1 ml) was then added, and the reaction mixture was stirred for 15 h at room temperature. Saturated sodium hydrogen carbonate solution (5 ml) was then added to the reaction mixture, and then the aqueous phase was extracted with dichloromethane (2×10 ml). The combined organic phases were extracted with saturated sodium chloride solution (10 ml), dried over sodium sulfate and concentrated in vacuo. The crude product was purified by flash chromatography using ethyl acetate/hexane (20:1). 3-((4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperazin-1-yl)methyl)benzonitrile (100 mg, 0.180 mmol) was dissolved in methyl ethyl ketone (3 ml), and chlorotrimethylsilane (27 μl, 0.216 mmol) was added slowly. Diethyl ether (10 ml) was then added, and the mixture was stirred for 1 h at 0° C. The resulting precipitate was filtered off, dried with the exclusion of air and washed with diethyl ether.
  • Yield: 100 mg (42%), white solid
  • 1H-NMR (400 MHz, DMSO-d6): 1.24 (1H); 1.54 (4H); 1.79 (1H); 2.53 (6H); 2.79 (3H); 2.94 (2H); 3.10 (1H); 3.28 (3H); 3.36 (5H); 3.55 (1H); 3.69 (1H); 3.85 (1H); 4.12 (2H); 4.39 (2H); 6.79 (2H); 7.69 (1H); 7.95 (2H); 8.10 (1H); 11.65 (1H).
    • Example 93 3-((4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)-methoxy)acetyl)piperazin-1-yl)methyl)benzonitrile hydrochloride
  • Figure US20080153843A1-20080626-C00114
  • N,N′Carbonyldiimidazole (71 mg, 0.441 mmol) was added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetic acid (150 mg, 0.420 mmol) in dichloromethane (7 ml), and the mixture was stirred for 1 h at room temperature. A solution of 3-(piperazin-1-ylmethyl)benzonitrile (84 mg, 0.420 mmol) in dichloromethane (3 ml) was then added, and the reaction mixture was stirred for 15 h at room temperature. Saturated sodium hydrogen carbonate solution (10 ml) was then added to the reaction mixture, and then the aqueous phase was extracted with dichloromethane (2×10 ml). The combined organic phases were extracted with saturated sodium chloride solution (10 ml), dried over sodium sulfate and concentrated in vacuo. The crude product was purified by flash chromatography using ethyl acetate/hexane/ammonia solution (25% aq.) (100:10:1). 3-((4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetyl)piperazin-1-yl)methyl)benzonitrile (190 mg, 0.351 mmol) was dissolved in acetone/diethyl ether (1:1; 8 ml), and chlorotrimethylsilane (89 μl, 0.702 mmol) was added slowly. Diethyl ether (10 ml) was then added, and the mixture was stirred for 1 h at 0° C. The resulting precipitate was filtered off, dried with the exclusion of air and washed with diethyl ether.
  • Yield: 200 mg (83%), white solid
  • HPLC-MS, m/z 541.2 (MH+)
    • Example 94 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone hydrochloride
  • Figure US20080153843A1-20080626-C00115
  • N,N′-Carbonyldiimidazole (68 mg, 0.424 mmol) was added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid (150 mg, 0.404 mmol) in dichloromethane (4 ml), and the mixture was stirred for 1 h at room temperature. A solution of 4-(2-(pyrrolidin-1-yl)ethyl)piperidine (73 mg, 0.404 mmol) in dichloromethane (1 ml) was then added, and the reaction mixture was stirred for 15 h at room temperature. Saturated sodium hydrogen carbonate solution (5 ml) was then added to the reaction mixture, and then the aqueous phase was extracted with dichloromethane (2×10 ml). The combined organic phases were extracted with saturated sodium chloride solution (10 ml), dried over sodium sulfate and concentrated in vacuo. The crude product was purified by flash chromatography using ethyl acetate/methanol/ammonia solution (25% aq.) (400:100:5). 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone (160 mg, 0.299 mmol) was dissolved in methyl ethyl ketone (3 ml), and trimethylchlorosilane (75 μl, 0.358 mmol) was added slowly. Diethyl ether (10 ml) was then added, and the mixture was stirred for 1 h at 0° C. The resulting precipitate was filtered off, dried with the exclusion of air and washed with diethyl ether.
  • Yield: 100 mg (43%), white solid
  • 1H-NMR (400 MHz, DMSO-d6): 1.25 (1H); 1.60 (10H); 1.84 (4H); 1.97 (2H); 2.53 (6H); 2.92 (5H); 3.11 (2H); 3.30 (2H); 3.50 (1H); 3.66 (3H); 3.80 (5H); 4.03 (2H); 4.29 (1H); 6.80 (2H); 10.69 (1H).
    • Example 95 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
  • Figure US20080153843A1-20080626-C00116
  • N,N′-Carbonyldiimidazole (71 mg, 0.441 mmol) was added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetic acid (150 mg, 0.420 mmol) in dichloromethane (7 ml), and the mixture was stirred for 1 h at room temperature. A solution of 4-(2-(pyrrolidin-1-yl)ethyl)piperidine (76 mg, 0.420 mmol) in dichloromethane (3 ml) was then added, and the reaction mixture was stirred for 15 h at room temperature. Saturated sodium hydrogen carbonate solution (10 ml) was then added to the reaction mixture, and then the aqueous phase was extracted with dichloromethane (2×10 ml). The combined organic phases were extracted with saturated sodium chloride solution (10 ml), dried over sodium sulfate and concentrated in vacuo. The crude product was purified by flash chromatography using ethyl acetate/methanol/ammonia solution (25% aq.) (400:100:5).
  • Yield: 190 mg (87%), colorless oil
  • HPLC-MS, m/z 522.3 (MH+)
    • Example 96 1-(3,4-dihydro-2,6-naphthyridin-2(1H)-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone hydrochloride
  • Figure US20080153843A1-20080626-C00117
  • N,N′-Carbonyldiimidazole (68 mg, 0.424 mmol) was added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid (150 mg, 0.404 mmol) in dichloromethane (4 ml), and the mixture was stirred for 1 h at room temperature. A solution of 1,2,3,4-tetrahydro-2,6-naphthyridine (54 mg, 0.404 mmol) in dichloromethane (1 ml) was then added, and the reaction mixture was stirred for 15 h at room temperature. Saturated sodium hydrogen carbonate solution (5 ml) was then added to the reaction mixture, and then the aqueous phase was extracted with dichloromethane (2×10 ml). The combined organic phases were extracted with saturated sodium chloride solution (10 ml), dried over sodium sulfate and concentrated in vacuo. The crude product was purified by flash chromatography using ethyl acetate/methanol (20:1). 1-(3,4-dihydro-2,6-naphthyridin-2(1H)-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone (197 mg, 0.404 mmol) was dissolved in methyl ethyl ketone (5 ml), and trimethylchlorosilane (61 μl, 0.516 mmol) was added slowly. Diethyl ether (10 ml) was then added, and the mixture was stirred for 1 h at 0° C. The resulting precipitate was filtered off, dried with the exclusion of air and washed with diethyl ether.
  • Yield: 135 mg (64%), white solid
  • 1H-NMR (400 MHz, DMSO-d6): 1.25 (1H); 1.55 (4H); 1.80 (1H); 2.52 (6H); 2.96 (3H); 3.27 (2H); 3.58 (2H); 3.72 (2H); 3.77 (3H); 3.84 (1H); 4.20 (2H); 4.85 (2H); 6.77 (2H); 7.85 (1H); 8.69 (1H); 8.79 (1H); (OH masked).
    • Reaction of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid (acid structural unit S27) with amines (R5R6NH)
  • Figure US20080153843A1-20080626-C00118
  • The example compounds listed in the following table were prepared from acid structural unit S27 by reaction with the corresponding amines (R5R6NH) closely following the processes described for Examples 8 and 92-96. The amines used are commercially available, can be prepared by methods known to the person skilled in the art, or were synthesized according to described processes. Instead of the solvent dichloromethane, the solvent N,N-dimethylformamide was used in the synthesis of the following example compounds: Example 113, 143 and 146. For the preparation of example compounds in which amines were used which were not in the form of the free base but in the form of the corresponding hydrochlorides (×HCl), a corresponding amount of triethylamine was added to the reaction (eq. Et3N=×HCl). For Example 99, the formation of the hydrochloride was carried out analogously to the process described for Example 97. Examples 106 and 112 were converted into the corresponding hydrochlorides (×HCl) by the following general process: The free bases were in each case dissolved in a small amount of methyl ethyl ketone, and 2 M hydrogen chloride solution in diethyl ether (4-5 eq.) was added. Where appropriate, the mixture was cooled to 0° C. and/or diethyl ether was added before the hydrochloride (×HCl) was filtered out.
  • Example No. Amine (R5R6NH) Yield (%) MS, m/z (MH+)
     98 2-(piperidin-4-yl)octahydro-1H-pyrido[1,2-a]pyrazine 94 577.3
    trihydrochloride
     99 2-(piperidin-4-yl)octahydro-1H-pyrido[1,2-a]pyrazine 30 577.3
    trihydrochloride
    100 2-(piperidin-4-yl)-1,2,3,4-tetrahydro-2,6-naphthyridine 82 571.3
    trihydrochloride
    1011 tert-butyl piperazine-1-carboxylate 89 540.3
    103 5-(piperidin-4-yl)-3-(pyridin-4-yl)-1,2,4-oxadiazole 89 584.3
    106 1-((1-methylpiperidin-4-yl)methyl)piperazine 87 551.3
    112 1-methyl-4-(piperidin-4-yl)piperazine 69 537.3
    113 4-(piperazin-1-yl)thieno[3,2-d]pyrimidine 78 574.2
    143 2-(1-(pyridin-4-yl)piperidin-4-yl)ethanamine 55 559.2
    dihydrochloride2
    146 (4-methylpiperazin-1-yl)(piperidin-4-yl)methanone 66 565.2
    hydrochloride (xHCl)
    147 1-(pyridin-4-yl)piperazine 62 517.2
    165 3-(piperidin-4-yloxy)pyridine hydrochloride 23 532.2
    168 7-(piperazin-1-yl)-4-(pyrrolidin-1-yl)quinazoline 63 637.3
    dihydrochloride (C)
    188 4-(piperidin-4-ylmethoxy)pyridine dihydrochloride 82 546.3
    1This compound was additionally also obtained in a smaller yield of 80% by reaction in the presence of ECDI/HOBt in dichloromethane.
    2The amine can be prepared analogously to the synthesis described in WO 2006/071775.
    • Preparation of the Amines: 2-(piperidin-4-yl)-1,2,3,4-tetrahydro-2,6-naphthyridine trihydrochloride (Used in the Synthesis of Example Compound 100)
  • Figure US20080153843A1-20080626-C00119
  • (i) Pd(PPh3)2Cl2 (1.07 g, 1.52 mmol), trimethylsilylacetylene (18.9 ml, 133 mmol), 1,4-diazabicyclo[2.2.2]octane (DABCO) (17.1 g, 152 mmol) and copper(I) iodide (145 mg, 0.76 mmol) were added in succession, under nitrogen, to a solution of 3-bromo-4-pyridine carboxaldehyde (14.16 g, 76.1 mmol) in dry tetrahydrofuran (140 ml). The reaction mixture was stirred for 1 h, filtered off over Celite, washed with tetrahydrofuran and concentrated. The residue was purified by column chromatography (heptane/ethyl acetate, 9:1→9:2).
  • Yield: 14.62 g (94%)
  • (ii) A solution of 3-((trimethylsilyl)ethynyl)isonicotinaldehyde (13.22 g, 65.0 mmol) in ethanol (300 ml), under nitrogen, was refluxed for 7.5 h with the simultaneous continuous addition of ammonia. The mixture was then concentrated, and the residue was taken up in ethyl acetate and filtered over silica gel. The crude product was dissolved in hot hexane and decanted off twice. The filtrate was concentrated and crystallized from hexane/diisopropyl ether.
  • Yield: 3.29 g (39%)
  • (iii) Platinum(IV) oxide (223 mg, 0.984 mmol) was added to a suspension of calcium oxide (758 mg, 13.5 mmol) and 2,6-naphthyridine (1.60 g, 12.3 mmol) in 2-methoxyethanol (15 ml), under nitrogen. The reaction mixture was stirred overnight under a hydrogen atmosphere and then filtered over Celite, washed with ethanol, concentrated in vacuo and coevaporated with dichloromethane. The residue was taken up in ethyl acetate, filtered over a microfilter, washed with ethyl acetate and concentrated again. The residue was combined with a second batch, which was prepared analogously (from 1.66 g (12.8 mmol) of 2,6-naphthyridine), and coevaporated with toluene (2×) and dichloromethane (2×). The crude product was then dried overnight in vacuo. Purification was carried out by means of column chromatography (heptane/dichloromethane/7 M ammonia solution in methanol, 10:30:2). Coevaporation with dichloromethane was then carried out.
  • Yield: 2.83 g (84%)
  • (iv) 1,2,3,4-tetrahydro-2,6-naphthyridine (1.16 g, 8.65 mmol) and tert-butyl 4-oxopiperidine-1-carboxylate (1.72 g, 8.65 mmol) were dissolved in 1,2-dichloroethane (20.5 ml). Sodium triacetoxyborohydride (2.56 g, 12.10 mmol) and acetic acid (0.49 ml, 8.65 mmol) were added to this solution at room temperature. The reaction mixture was stirred for 15 h at room temperature, and then saturated sodium hydrogen carbonate solution (20 ml) was added and stirring was carried out for 30 min. The aqueous phase was extracted with diethyl ether (2×30 ml) and the organic phase was in turn washed with saturated sodium chloride solution (20 ml). The organic phase was dried (MgSO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) using ethyl acetate/hexane/methanol/ammonia solution (25% aq.) (100:10:10:1).
  • Yield: 2.26 g (82%)
  • (v) Hydrogen chloride (28.48 ml, 35.60 mmol, 1.25 M solution in methanol) was added at room temperature to a solution of tert-butyl 4-(3,4-dihydro-2,6-naphthyridin-2(1H)-yl)-piperidine-1-carboxylate (2.26 g, 7.12 mmol) in methanol (10 ml). The reaction mixture was refluxed for 30 min. The solvent was removed in vacuo, the residue was taken up in a small amount of ethanol, and diethyl ether was added. The mixture was then cooled in an ice bath for 30 min., and the resulting solid was filtered off and dried.
  • Yield: 2.09 g (90%)
    • 2-(piperidin-4-yl)octahydro-1H-pyrido[1,2-a]pyrazine trihydrochloride (Used in the Synthesis of Examples 98 and 99)
  • The amine was prepared analogously to 2-(piperidin-4-yl)-1,2,3,4-tetrahydro-2,6-naphthyridine trihydrochloride from octahydro-1H-pyrido[1,2-a]pyrazine and tert-butyl 4-oxopiperidine-1-carboxylate (steps iv and v).
    • (4-methylpiperazin-1-yl)(piperidin-4-yl)methanone hydrochloride (Used in the Synthesis of Example Compound 146)
  • Figure US20080153843A1-20080626-C00120
  • (i) 1-methylpiperazine (2.20 ml, 19.84 mmol) and 4-methylmorpholine (4.37 ml, 39.68 mmol) were added to a solution of 1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (5.0 g, 21.82 mmol) in N,N-dimethylformamide (76.3 ml). Benzotriazol-1-yloxytris-(dimethylamino)phosphonium hexafluorophosphate (11.44 g, 25.79 mmol) was then added to the mixture, and stirring was carried out for 15 h at room temperature. Concentration in vacuo was then carried out. The residue was taken up in ethyl acetate (100 ml) and saturated sodium hydrogen carbonate solution (100 ml), and the aqueous phase was extracted with ethyl acetate (2×30 ml). The combined organic phases were washed with saturated sodium chloride solution (30 ml), dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) using ethyl acetate/methanol/ammonia solution (25% aq.) (40:10:0.5).
  • Yield: 5.61 g (83%)
  • (ii) Hydrogen chloride (49.46 ml, 61.83 mmol, 1.25 M solution in methanol) was added at room temperature to tert-butyl 4-(4-methylpiperazine-1-carbonyl)piperidine-1-carboxylate (4.81 g, 15.46 mmol), and the reaction mixture was refluxed for 1 h. The solvent was removed in vacuo, and the residue was taken up in a small amount of ethanol; methyl ethyl ketone and diethyl ether were added, and refluxing was carried out for 40 min. The mixture was then cooled slowly to room temperature and then cooled for 30 min. in an ice bath. The resulting solid was filtered off and dried.
  • Yield: 3.83 g (88%)
    • 3-(piperidin-4-yloxy)pyridine hydrochloride (Used in the Synthesis of Example Compound 165)
  • Figure US20080153843A1-20080626-C00121
  • (i) tert-butyl-4-hydroxypiperidine-1-carboxylate (1.85 g, 9.20 mmol) and triphenylphosphine (2.41 g, 9.20 mmol) were added at room temperature to a solution of 3-pyrrolidinol (700 mg, 7.36 mmol) in tetrahydrofuran (10 ml). Diisopropyl-azodicarboxylate (1.79 ml, 125.1 mmol) was then added dropwise, and the mixture was then stirred for 15 h at 55° C. The solvent was removed in vacuo, and the residue was taken up in 1 M hydrochloric acid (20 ml) and extracted with dichloromethane (2×10 ml). The combined organic phases were extracted with 1 M hydrochloric acid (20 ml) and water (20 ml). The aqueous phases were combined, adjusted to pH 12 with 1 M sodium hydroxide solution and then extracted with dichloromethane (4×20 ml). The organic phase was then washed with saturated sodium chloride solution (20 ml), dried (Na2SO4) and concentrated in vacuo. The crude product was then purified by column chromatography (silica gel) using ethyl acetate/hexane (10:1).
  • Yield: 410 mg (20%)
  • [analogous process see: J. Chao et al., Tetrahedron Lett., 2007, 48, 791]
  • (ii) Hydrogen chloride (4.71 ml, 5.89 mmol, 1.25 M solution in methanol) was added at room temperature to a solution of tert-butyl 4-(pyridin-3-yloxy)piperidine-1-carboxylate (410 mg, 1.473 mmol) in methanol (2-5 ml), and the reaction mixture was refluxed for 30 min. The solvent was removed in vacuo, the residue was taken up in a small amount of ethanol, and diethyl ether was added. Cooling in an ice bath was then carried out for 30 min., and the resulting solid was filtered off and dried.
  • Yield: 270 mg (85%)
    • 4-(piperidin-4-ylmethoxy)pyridine dihydrochloride (Used in the Synthesis of Example Compound 188)
  • The amine was prepared analogously to 3-(piperidin-4-yloxy)pyridine hydrochloride from tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate and 3-pyrrolidinol.
    • 7-(piperazin-1-yl)-4-(pyrrolidin-1-yl)quinazoline dihydrochloride (C) (Used in the Synthesis of Example Compound 168)
  • Figure US20080153843A1-20080626-C00122
  • 7-Chloro-4-(pyrrolidin-1-yl)quinazoline (A) was prepared from 2-amino-4-chlorobenzoic acid analogously to the following procedure, known from the literature, for the preparation of aminoquinazolines: H. Hayashi et al., Bioorg. Med. Chem., 2003, 11, 383. [Review zur Synthese von Chinazolinen: P. J. Guiry et al., Tetrahedron, 2005, 61, 10153.]
    • tert-butyl 4-(4-(pyrrolidin-1-yl)quinazolin-7-yl)piperazine-1-carboxylate (B)
  • Potassium tert-butoxide (998 mg, 8.99 mmol), 2-dicyclohexylphosphino-2,4,6-triisopropyl-biphenyl (X-Phos) (79 mg, 0.18 mmol) and tris-(dibenzylideneacetone)-dipalladium [Pd2(dba)3] (36 mg, 0.036 mmol) were added, under nitrogen, to a mixture of 7-chloro-4-(pyrrolidin-1-yl)quinazoline (A) (840 mg, 3.59 mmol) and tert-butyl piperazine-1-carboxylate (1.0 g, 5.39 mmol) in toluene (49 ml). The reaction mixture was then heated for 15 h at 100° C. The reaction mixture was cooled to room temperature, and water (25 ml) and ethyl acetate (25 ml) were added. The aqueous phase was extracted with ethyl acetate (2×25 ml), and the combined organic phases were washed with saturated sodium chloride solution (20 ml). The organic phase was then dried (MgSO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) using ethyl acetate/dichloromethane/ammonia solution (25% aq.) (50:10:0.5) and ethyl acetate/dichloro-methane/methyl tert-butyl ether/ammonia solution (25% aq.) (50:10:10:0.7).
  • Yield: 700 mg (51%)
    • 7-(piperazin-1-yl)-4-(pyrrolidin-1-yl)quinazoline dihydrochloride (C)
  • tert-butyl 4-(4-(pyrrolidin-1-yl)quinazolin-7-yl)piperazine-1-carboxylate (B) (130 mg, 0.339 mmol) was dissolved at room temperature in methanol (2 ml), and then hydrogen chloride (2.71 ml, 3.39 mmol, 1.25 M solution in methanol) was added. The reaction mixture was refluxed for 1 h and then stirred for 15 h at room temperature. Concentration in vacuo was carried out, and the residue was taken up in a small amount of ethanol and heated. Diethyl ether was then added, the mixture was cooled in an ice bath, and finally the resulting solid was filtered off.
  • Yield: 103 mg (85%)
    • Reaction of 2-((1-(benzo[b]thiophen-3-ylsulfonyl)piperidin-2-yl)methoxy)acetic acid (acid structural unit S32) with 1-(1-methylpiperidin-4-yl)piperazine Example 137 2-((1-(Benzo[b]thiophen-3-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
  • Figure US20080153843A1-20080626-C00123
  • Example Compound 137 was prepared from acid structural unit S32 in a yield of 79% by reaction with 1-(1-methylpiperidin-4-yl)piperazine closely following the process described for Examples 8 and 92-96. MS, m/z 535.2 (MH+)
    • Reaction of 2-(2-(1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)ethoxy)-acetic acid with 1-(1-methylpiperidin-4-yl)piperazine Example 164 2-(2-(1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)ethoxy)-1-(4-(1-methyl-piperidin-4-yl)piperazin-1-yl)ethanone
  • Figure US20080153843A1-20080626-C00124
  • Example compound 164 was prepared from the corresponding acid structural unit in a yield of 80% by reaction with 1-(1-methylpiperidin-4-yl)piperazine closely following the process described for Examples 8 and 92-96. The acid structural unit was prepared analogously to the process described under Method 1 for the preparation of acid structural units for parallel synthesis.
  • MS, m/z 551.2 (MH+)
    • Reaction of 2-((2-(naphthalen-2-ylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-methoxy)acetic acid with 1-(1-methylpiperidin-4-yl)piperazine Example 178 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((2-(naphthalen-2-ylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)ethanone dihydrochloride
  • Figure US20080153843A1-20080626-C00125
  • Example Compound 178 was prepared from the corresponding acid structural unit in a yield of 29% by reaction with 1-(1-methylpiperidin-4-yl)piperazine closely following the process described for Examples 8 and 92-96. The acid structural unit was prepared analogously to the process described under Method 1 for the preparation of acid structural units for parallel synthesis. The hydrochloride precipitation of the free base relating to Example 178 was carried out from a methyl ethyl ketone/diethyl ether solution of the base with addition of 2 M hydrogen chloride solution in diethyl ether.
  • MS, m/z 577.2 (MH+)
    • Reaction of 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-(piperidin-2-ylmethoxy)-ethanone trihydrochloride with sulfonyl chlorides
  • Figure US20080153843A1-20080626-C00126
    • 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-(piperidin-2-ylmethoxy)ethanone trihydrochloride
  • Step (i): tert-butyl 2-bromoacetate (4.1 ml, 27.88 mmol) was added at room temperature to a mixture of tetra-n-butylammonium hydrogen sulfate (625 mg, 1.859 mmol), aqueous sodium hydroxide solution (18.58 g, 464.69 mmol in water (20 ml)) and toluene (15 ml), and then the mixture was cooled to 0° C. A solution of tert-butyl 2-(hydroxymethyl)piperidine-1-carboxylate (4.0 g, 18.587 mmol) in toluene (10 ml) was then added slowly. The reaction mixture was heated to room temperature and stirred for 1 h at that temperature. The phases were separated and the aqueous phase was extracted with diethyl ether (2×25 ml). The combined organic phases were washed with saturated sodium chloride solution (20 ml), dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) using hexane/diethyl ether (3:1).
  • Yield: 3.53 g (58%)
  • Step (ii): tert-butyl 2-((2-tert-butoxy-2-oxoethoxy)methyl)piperidine-1-carboxylate (3.53 g, 10.717 mmol) was dissolved in tetrahydrofuran (20 ml), and sodium hydroxide solution (1.71 g, 42.87 mmol in water (2 ml)) was added. The reaction mixture was heated for 3 h at 90° C. and then cooled to room temperature again. The pH value of the mixture was adjusted to pH 2 with 2M hydrochloric acid, and extraction with ethyl acetate (3×30 ml) was then carried out. The combined organic phases were dried (Na2SO4) and concentrated in vacuo. The crude product was used in the next synthesis step without being purified further.
  • Yield: 3.28 g (>99%)
  • Step (iii): N,N′-Carbonyldiimidazole (2.02 g, 12.563 mmol) was added to a solution of 2-((1-(tert-butoxycarbonyl)piperidin-2-yl)methoxy)acetic acid (3.27 g, 11.965 mmol) in dichloromethane (15 ml), and stirring was carried out for 1.5 h at room temperature. A solution of 1-(1-methylpiperidin-4-yl)piperazine (2.19 g, 11.965 mmol) in dichloromethane (15 ml) was then added, and the reaction mixture was stirred for 3 d at room temperature. Saturated sodium hydrogen carbonate solution (30 ml) was added to the mixture, and then the aqueous phase was extracted with dichloromethane (2×30 ml). The combined organic phases were washed with saturated sodium chloride solution (30 ml), dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) using ethyl acetate/methanol/dichloromethane/ammonia solution (25% aq.) (400:100:100:5).
  • Yield: 4.57 g (87%)
  • Step (iv): Hydrogen chloride (26.0 ml, 52.10 mmol, 2 M solution in diethyl ether) was added at room temperature to a solution of tert-butyl 2-((2-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-oxoethoxy)methyl)piperidine-1-carboxylate (4.57 g, 10.42 mmol) in a mixture of ethyl acetate (15 ml) and diethyl ether (50 ml). The reaction mixture was stirred for 2 h at 45° C. Then the resulting white solid was filtered off and dried.
  • Yield: 3.59 g (77%)
    • Example 107 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
  • Step (v): Triethylamine (0.221 ml, 1.608 mmol) and then 2,4,6-trimethylbenzenesulfonyl chloride (105 mg, 0.482 mmol) were added at 0° C. to a solution of 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-(piperidin-2-ylmethoxy)ethanone trihydrochloride (180 mg, 0.402 mmol) in tetrahydrofuran (10 ml). The reaction mixture was heated slowly to room temperature, stirred for 15 h at that temperature and then refluxed for 1 h. Saturated sodium hydrogen carbonate solution (5 ml) was then added to the mixture, and the aqueous phase was extracted with ethyl acetate (3×30 ml). The combined organic phases were dried (Na2SO4) and concentrated in vacuo, and the crude product was then purified by column chromatography (silica gel) using ethyl acetate/methanol/ammonia solution (25% aq.) (300:100:5). Yield: 90 mg (43%), yellow oil; MS, m/z 520.3 (MH+)
    • Example 108 2-((1-(2,6-dichloro-4-(trifluormethyl)phenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
  • Step (v): 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-(piperidin-2-ylmethoxy)ethanone trihydrochloride (150 mg, 0.335 mmol) was dissolved at room temperature in a mixture of dichloromethane (5 ml) and triethylamine (0.208 ml, 1.507 mmol), and 2,6-dichloro-4-(trifluoromethyl)benzenesulfonyl chloride (156 mg, 0.503 mmol) in dichlormethane (5 ml) was added. The reaction mixture was stirred for 3 d at that temperature, and then saturated sodium hydrogen carbonate solution (5 ml) was added thereto. The aqueous phase was extracted with dichloromethane (2×20 ml), and the combined organic phases were dried (Na2SO4) and concentrated in vacuo. The crude product was then purified by column chromatography (silica gel) using ethyl acetate/methanol/ammonia solution (25% aq.) (200:100:3). Yield: 120 mg (58%), yellow oil; MS, m/z 614.2 (MH+)
  • The example compounds listed in the following table were prepared from 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-(piperidin-2-ylmethoxy)ethanone trihydrochloride by reaction with the corresponding sulfonyl chlorides (R1SO2Cl) closely following the process described for Example 108 (step (v)). The progress of the reaction was monitored by thin-layer chromatography; the reaction time was in most cases from 15 h to 3 d. The amounts of the reagents used varied as follows: sulfonyl chloride (from 0.9 to 1.5 eq.), triethylamine (3.5-4.5 eq.). The reactions were in some cases carried out in tetrahydrofuran as an alternative to dichloromethane. The sulfonyl chlorides used are commercially available, can be prepared by methods known to the person skilled in the art, or were synthesized according to described processes. Furthermore, for Examples 141, 155, 156, 158, 159, 169 and 170, the bases were converted into the corresponding dihydrochlorides (2×HCl) according to the following general process: The free bases were in each case dissolved in a small amount of dichloromethane or methyl ethyl ketone, and 2 M hydrogen chloride solution in diethyl ether (4-5 eq.) was added. In some cases, the mixture was cooled to 0° C. and/or diethyl ether was added thereto, before the dihydrochloride was filtered out.
  • Example No. Sulfonyl chloride (R1SO2Cl) Yield (%) MS, m/z (MH+)
    109 2-Chloro-6-methylbenzene-1-sulfonyl 85 527.2
    chloride
    110 Naphthalene-1-sulfonyl chloride 79 529.3
    111 Naphthalene-2-sulfonyl chloride 79 529.3
    114 4-Chloro-2,5-dimethylbenzene-1-sulfonyl 24 541.2
    chloride
    115 4-Chloro-3-(trifluoromethyl)benzene-1- 51 581.2
    sulfonyl chloride
    118 2,4,6-Trichlorobenzene-1-sulfonyl chloride 46 583.1
    119 2,4,6-Triisopropylbenzene-1-sulfonyl chloride 54 605.4
    120 2,4-dichlorobenzene-1-sulfonyl chloride 60 547.2
    128 5-Chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl 39 531.3
    chloride
    129 6-Chloroimidazo[2,1-b]thiazole-5-sulfonyl 37 559.2
    chloride
    131 3-(o-Tolyloxy)benzene-1-sulfonyl chloride 71 585.3
    138 2-Chloro-4-(trifluoromethyl)benzene-1- 48 581.2
    sulfonyl chloride
    139 2-Chlorobenzene-1-sulfonyl chloride 38 513.1
    141 2,6-dichlorobenzene-1-sulfonyl chloride 43 547.1
    151 5-Chloro-3-methylbenzo[b]thiophene-2- 41 583.1
    sulfonyl chloride
    153 2,5-Bis(trifluoromethyl)benzene-1-sulfonyl 58 615.1
    chloride
    154 7-Chlorobenzo[c][1,2,5]oxadiazole-4-sulfonyl 27 555.1
    chloride
    155 4-methylnaphthalene-1-sulfonyl chloride 44 543.2
    156 2,4,5-Trichlorobenzene-1-sulfonyl chloride 21 581.0
    158 5-(Dimethylamino)naphthalene-1-sulfonyl 56 572.2
    chloride
    159 2-methylbenzene-1-sulfonyl chloride 55 493.2
    169 4-Fluoro-2,6-dimethylbenzene-1-sulfonyl 47 525.2
    chloride
    170 2,5-dichlorothiophene-3-sulfonyl chloride 54 553.1
    171 Benzo[b]thiophene-2-sulfonyl chloride 59 535.2
    172 2,5-Dimethylthiophene-3-sulfonyl chloride 57 513.2
    • Preparation of the Sulfonyl Chloride: 4-Fluoro-2,6-dimethylbenzene-1-sulfonyl chloride (Used in the Synthesis of Example Compound 169)
  • Figure US20080153843A1-20080626-C00127
  • Chlorosulfonic acid (54.3 ml, 4 eq.) was added dropwise at 0° C., over a period of 45 min., to a solution of 1-fluoro-3,5-dimethylbenzene (25 g) in dichloromethane (250 ml). The reaction mixture was then stirred for 1 h at room temperature, and the progress of the reaction was monitored by thin-layer chromatography. The reaction mixture was poured onto ice, and the aqueous phase was extracted with dichloromethane (3×150 ml). The organic phase was dried (Na2SO4) and concentrated in vacuo. The crude product was then purified by column chromatography. Yield: 19.5 g (44%), white solid.
    • Reaction of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone hydrochloride (Example 102) with Ketones and Aldehydes (RaRbC═O)
  • Figure US20080153843A1-20080626-C00128
    • Example 102 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone hydrochloride
  • Step (i): Hydrogen chloride (1.15 ml, 2.30 mmol, 2 M solution in diethyl ether) was added at room temperature to a solution of tert-butyl 4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperazine-1-carboxylate (Example 101) (310 mg, 0.574 mmol) in diethyl ether (2-5 ml). The reaction mixture was stirred for 2 h at room temperature and then refluxed for 10 min. The resulting solid was filtered off and dried. Yield: 210 mg (77%), white solid
  • Reaction with Ketones:
    • Example 104 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(tetrahydro-2H-pyran-4-yl)piperazin-1-yl)ethanone
  • Step (ii): 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone hydrochloride (Example 102) (90 mg, 0.189 mmol) and dihydro-2H-pyran-4(3H)-one (0.017 ml, 0.189 mmol) were dissolved in a mixture of 1,2-dichloroethane (4 ml) and triethylamine (0.026 ml, 0.189 mmol). Sodium triacetoxyborohydride (56 mg, 0.265 mmol) and acetic acid (0.011 ml, 0.189 mmol) were added at room temperature to that solution. The reaction mixture was stirred for 1 h at room temperature, and then saturated sodium hydrogen carbonate solution (5 ml) was added thereto. The aqueous phase was extracted with diethyl ether (2×20 ml), and the organic phase was in turn washed with saturated sodium chloride solution (10 ml). The organic phase was dried (MgSO4) and concentrated in vacuo, and the crude product was purified by column chromatography (silica gel) using ethyl acetate/methanol (10:1). Yield: 90 mg (91%), yellow oil; MS, m/z 524.3 (MH+)
  • The example compounds listed in the following table were prepared from 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone hydrochloride (Example 102) by reaction with the corresponding ketones (RaRbC═O) closely following the process described for Example 104 (step (ii)). The reactions were monitored by thin-layer chromatography and had reaction times of from 1 to 15 h. The ketones used are commercially available.
  • Example Yield
    No. Ketone (RaRbC═O) (%) MS, m/z (MH+)
    105 4-methylcyclohexanone 20 536.3
    134 4-(trifluoromethyl)cyclohexanone 19 590.3

    Reaction with Aldehydes:
    • Example 117 1-(4-((1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)piperidin-2-yl)methoxy)ethanone
  • Step (ii): 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone hydrochloride (Example 102) (150 mg, 0.315 mmol) was suspended in a mixture of tetrahydrofuran (3 ml) and triethylamine (0.052 ml, 0.378 mmol). 1H-benzo[d]-imidazole-2-carbaldehyde (55 mg, 0.378 mmol) was added at room temperature to the suspension, and the resulting mixture was stirred for 10 min. at room temperature. Sodium triacetoxyborohydride (267 mg, 1.26 mmol) was then added, and stirring was carried out for a further 3 d at room temperature. Saturated sodium hydrogen carbonate solution (5 ml) was added to the reaction mixture, and extraction with ethyl acetate (4×10 ml) was carried out. The organic phase was dried (MgSO4) and concentrated in vacuo, and the crude product was purified by column chromatography (silica gel) using ethyl acetate/methanol/ammonia solution (25% aq.) (100:1:1). Yield: 60 mg (33%), yellow solid; MS, m/z 570.3 (MH+)
  • The example compound shown in the following table was prepared from 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone hydrochloride (Example 102) by reaction with the corresponding aldehyde (RaRbC═O) closely following the process described for Example 117 (step (ii)). The aldehyde used is commercially available.
  • Yield
    Example No. Aldehyde (RaRbC═O) (%) MS, m/z (MH+)
    166 Quinoxaline-6-carbaldehyde 90 582.2
    • Reaction of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone with aldehydes (RaHC═O)
  • Figure US20080153843A1-20080626-C00129
    • 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone
  • Step (i): Trifluoroacetic acid (13 eq.) was added at 0° C. to a solution of tert-butyl 4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperazine-1-carboxylate (Example 101) (1 eq.) in dichloromethane (10 ml/mmol). The reaction mixture was stirred for 2 h at room temperature and then concentrated in vacuo. The crude product was used in the next synthesis step without being purified further.
    • Example 197 1-(4-((5-Chloro-2-phenyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
  • Step (ii): 4-Chloro-2-phenyl-1H-imidazole-5-carbaldehyde (1.5 eq.) and acetic acid (cat.) were added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone (1 eq.) in dichloromethane (25 ml/mmol). The reaction mixture was stirred for 30 min. at 25° C., then sodium triacetoxyborohydride (4 eq.) was added and stirring was carried out for a further 16 h at 25° C. The mixture was diluted with dichloromethane and washed with saturated bicarbonate solution and saturated sodium chloride solution. The organic phase was dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography using 3% methanol in ethyl acetate. Yield: 50%; MS, m/z 630.2 (MH+)
  • The example compounds listed in the following table were prepared from 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone by reaction with the corresponding aldehydes (RaHC═O) closely following the process described for Example 197 (step (ii)). The aldehydes used are commercially available, can be prepared by methods known to the person skilled in the art, or were synthesized according to described processes.
  • Example No. Aldehyde (RaHC═O) Yield (%) MS, m/z (MH+)
    198 1,5-Dimethyl-1H-pyrazole-4-carbaldehyde 40 548.2
    199 2-(Dimethylamino)pyrimidine-5-carbaldehyde 30 575.2
    212 2-(1-methylpiperidin-4-yl)acetaldehyde 40 565.3
    214 2-((4-Fluorophenyl)(methyl)amino)pyrimidine-5- 10 655.3
    carbaldehyde
    • Preparation of the Aldehydes: 2-((4-Fluorophenyl)(methyl)amino)pyrimidine-5-carbaldehyde (Used in the Synthesis of Example Compound 214)
  • Figure US20080153843A1-20080626-C00130
  • Step (i): To a solution of 5-bromo-2-chloropyrimidine (2.5 mmol) in dimethyl sulfoxide (6.5 ml) there was added 4-fluoro-N-methylaniline, followed by potassium carbonate (5 mmol). The resulting solution was heated for 2 h at 120° C., and the progress of the reaction was monitored by thin-layer chromatography. When the reaction was complete, the reaction mixture was extracted with ethyl acetate, and the organic phase was washed with water and saturated sodium chloride solution. The organic phase was dried (Na2SO4), filtered and concentrated in vacuo. The crude product was purified by column chromatography (5% ethyl acetate in hexane). Yield: 35%
  • Step (ii): Copper cyanide (2 eq.) was added to a solution of 5-bromo-N-(4-fluorophenyl)-N-methylpyrimidine-2-amine (1 mmol) in dimethylformamide (3 ml/mmol). The resulting solution was heated for 18 h at 100° C., and the progress of the reaction was monitored by thin-layer chromatography. When the reaction was complete, the reaction mixture was extracted with ethyl acetate, and the organic phase was washed with water and saturated sodium chloride solution. The organic phase was dried (Na2SO4), filtered and concentrated in vacuo. The crude product was purified by column chromatography (20% ethyl acetate in hexane). Yield: 25%
  • Step (iii): Diisobutylaluminium hydride (1 M solution, 0.75 mmol) was added to a cold solution of 2-((4-fluorophenyl)(methyl)amino)pyrimidine-5-carbonitrile (0.5 mmol) in benzene (8 ml). The resulting solution was stirred for 4 h at 25° C. The reaction mixture was then cooled to 0° C. again, and 10% hydrochloric acid (5 ml) was added dropwise. The mixture was then heated slowly to 25° C. and stirred for 2 h. The reaction mixture was neutralized with saturated bicarbonate solution and extracted with ethyl acetate. The organic phase was washed with saturated sodium chloride solution, dried (Na2SO4), filtered and concentrated in vacuo. The crude product was used directly in the next synthesis step.
    • 2-(1-methylpiperidin-4-yl)acetaldehyde (Used in the Synthesis of Example Compound 212)
  • Figure US20080153843A1-20080626-C00131
  • Step (i): A solution of potassium tert-butoxide (13.27 mmol) in tetrahydrofuran (2 ml/mmol) was added dropwise at 0° C., under argon, to a solution of methoxy-methyl-triphenyl-phosphine (8.84 mmol) in dry tetrahydrofuran (2 ml/mmol). The resulting solution was stirred for 30 min. at 25° C. The reaction mixture was then cooled to 0° C., and a solution of 1-methylpiperidin-4-one (4.42 mmol) in dry tetrahydrofuran (2 ml/mmol) was added dropwise. The mixture was stirred for 16 h at 25° C. until the reaction was complete. The mixture was then cooled to 0° C., 6 N hydrochloric acid (22 ml) was added dropwise, and stirring was carried out for 1 h. The aqueous phase was washed with diethyl ether (10 ml) and then rendered basic with 5 N sodium hydroxide solution and extracted with dichloromethane (4×75 ml). The organic phase was washed with saturated sodium chloride solution, dried (Na2SO4), filtered, and concentrated in vacuo. The crude product was used directly in the next synthesis step. Yield: 95%
  • Step (ii): A solution of potassium tert-butoxide (11.7 mmol) in dry tetrahydrofuran (2 ml/mmol) was added dropwise at 0° C., under argon, to a solution of methoxy-methyl-triphenylphosphine (7.8 mmol) in dry tetrahydrofuran (2 ml/mmol). The resulting solution was stirred for 30 min. at 25° C. The reaction mixture was then cooled to 0° C., and a solution of 1-methylpiperidine-4-carbaldehyde (3.9 mmol) in dry tetrahydrofuran (2 ml/mmol) was added dropwise. The mixture was stirred for 16 h at 25° C. until the reaction was complete. The mixture was then cooled to 0° C., 6 N hydrochloric acid (22 ml) was added dropwise, and stirring was carried out for 1 h. The aqueous phase was washed with diethyl ether (10 ml) and then rendered basic with 5 N sodium hydroxide solution and extracted with dichloromethane (4×75 ml). The organic phase was washed with saturated sodium chloride solution, dried (Na2SO4), filtered, and concentrated in vacuo. The crude product was used directly in the next synthesis step. Yield: 95%
    • Reaction of 1-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperidin-4-one (Example 116) with amines (RcRdNH)
  • Figure US20080153843A1-20080626-C00132
    • Example 116 1-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperidin-4-one
  • Step (i): 4-piperidone monohydrate hydrochloride (260 mg, 2.692 mmol), triethylamine (0.560 ml, 4.038 mmol) and then 4-methylmorpholine (1.62 ml, 14.805 mmol) were added to a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetic acid (acid structural unit S27) (1.0 g, 2.692 mmol) in N,N-dimethylformamide (20 ml). Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (1.42 g, 3.230 mmol) was then added to the mixture, and stirring was carried out for 3 d at room temperature. The mixture was then concentrated in vacuo, and the residue was taken up in ethyl acetate (30 ml) and saturated sodium hydrogen carbonate solution (20 ml); the aqueous phase was extracted with ethyl acetate (4×10 ml). The combined organic phases were washed with saturated sodium hydrogen carbonate solution (20 ml) and saturated sodium chloride solution (20 ml), dried (MgSO4), and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) using diethyl ether/dichloromethane/ammonia solution (25% aq.) (100:100:2). Yield: 430 mg (35%); MS, m/z 540.3 (MH+)
    • Example 130 1-(4-Fluoro-1,4′-bipiperidin-1′-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)-piperidin-2-yl)methoxy)ethanone
  • Step (ii): 1-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)-piperidin-4-one (Example 116) (100 mg, 0.221 mmol) and 4-fluoropiperidine hydrochloride (30 mg, 0.221 mmol) were dissolved in a mixture of 1,2-dichloroethane (4 ml) and triethylamine (0.036 ml, 0.265 mmol). Sodium triacetoxyborohydride (66 mg, 0.309 mmol) and acetic acid (0.013 ml, 0.221 mmol) were added at room temperature to the mixture. The reaction mixture was stirred for 15 h at room temperature, and then saturated sodium hydrogen carbonate solution (5 ml) was added thereto. The aqueous phase was extracted with diethyl ether (2×20 ml), and the organic phase was in turn washed with saturated sodium chloride solution (10 ml). The organic phase was dried (MgSO4) and concentrated in vacuo, and the crude product was purified by column chromatography (silica gel) using ethyl acetate/methanol (20:1). Yield: 70 mg (59%); MS, m/z 540.3 (MH+)
  • The example compounds listed in the following table were prepared from 1-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperidin-4-one (Example 116) by reaction with the corresponding amines (RcRdNH) closely following the process described for Example 130 (step (ii)). The reactions were monitored by thin-layer chromatography and had reaction times of about 15 h. In some cases, additional sodium triacetoxyborohydride was added subsequently. If the amine was not present in the form of the hydrochloride (×HCl), no triethylamine was added. The amines used are commercially available, can be prepared by methods known to the person skilled in the art, or were synthesized by described processes.
  • MS,
    Example No. Amines (RcRdNH) Yield (%) m/z (MH+)
    136 2-Morpholino-2-(pyridin-3- 79 644.4
    yl)ethanamine
    144 5,6,7,8-tetrahydroimidazo[1,2- 70 560.2
    a]pyrazine
    145 5,6,7,8-tetrahydro- 75 561.2
    [1,2,4]triazolo[1,5-a]pyrazine
    • Preparation of the Amines: 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (Used in the Synthesis of Example Compound 144)
  • Figure US20080153843A1-20080626-C00133
  • Step (i): A mixture of 2-aminopyrazine (25 g, 262.9 mmol) and chloroacetaldehyde (50% solution in water, 50 ml, 394 mmol) was heated for 2 d at 100° C. in the presence of sodium hydrogen carbonate (33.1 g, 394 mmol). The reaction mixture was cooled to room temperature, and saturated potassium carbonate solution (100 ml) was added thereto. Extraction with dichloromethane was then carried out, and the organic phase was dried (Na2SO4) and concentrated. Purification was carried out by column chromatography (dichloromethane/methanol 95:5+5% NH4OH [35%]). Yield: 7.6 g (24%)
  • Step (ii): Imidazo[1,2-a]pyrazine (7.2 g, 60.44 mmol) was dissolved in 2-methoxyethanol (100 ml). Platinum(IV) oxide (1.2 g, 5.13 mmol) was added, and the mixture was stirred overnight at room temperature, under a hydrogen atmosphere of 4 bar, in an autoclave. The reaction mixture was flooded with nitrogen, filtered over Celite, concentrated and coevaporated with toluene. Purification was carried out by column chromatography dichloromethane/7 N ammonia in methanol 95:5). Yield: 5.7 g (76%)
    • 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine (Used in the Synthesis of Example Compound 145)
  • Figure US20080153843A1-20080626-C00134
  • Step (i): N,N-Dimethylformamide dimethyl acetal (29.5 ml, 220 mmol) was added to a solution of pyrazine-2-amine (18.98 g, 200 mmol) in toluene (110 ml), and the mixture was refluxed for 2.25 h. The reaction mixture was cooled to room temperature, concentrated and coevaporated with toluene. Yield: 32.89 g (100%)
  • Step (ii): A solution of hydroxylamine hydrochloride (17.0 g, 245 mmol) in methanol (150 ml) was added dropwise, while cooling with ice, to a suspension of (E)-N,N-dimethyl-N′-(pyrazin-2-yl)formamide amide (38.27 g, 233 mmol) and sodium acetate (20.1 g, 245 mmol) in methanol (450 ml). The reaction mixture was stirred for 4 h at 0° C. and then heated to room temperature and concentrated. The residue was triturated with dichloromethane/7 M ammonia solution in methanol (˜9:1), and the desired solid was filtered off and washed with dichloromethane/7 M ammonia solution in methanol (˜9:1). The filtrate was concentrated, coevaporated with ethanol and then crystallized from ethanol. Further recrystallization of the resulting solids from ethanol finally yielded the purified product. Yield: 24.55 g (76%)
  • Step (iii): Polyphosphoric acid (250 g) was added to (Z)-N′-hydroxy-N-(pyrazin-2-yl)-formimide amide (25.07 g, 181 mmol), and the reaction mixture was then immediately heated to 90° C. The mixture was stirred for 4 h, and the hot reaction mixture was poured into ice-water and rendered basic with sodium hydrogen carbonate. The aqueous phase was extracted with dichloromethane (1 l, 3×0.5 l), and the combined organic phases were dried (Na2SO4) and concentrated. The crude product was crystallized from ethanol in several batches. Yield: 18.10 g (83%)
  • Step (iv): Platinum(IV) oxide (2.75 g, 12.1 mmol) was added, under nitrogen, to a suspension of calcium oxide (9.30 g, 166 mmol) and [1,2,4]triazolo[1,5-a]pyrazine (18.10 g, 151 mmol) in 2-methoxyethanol (150 ml). The reaction mixture was stirred for 21.5 h under a hydrogen atmosphere, filtered over Celite, and washed with dichloromethane/ethanol (9:1). The filtrate was concentrated, coevaporated with toluene and diisopropyl ether, and then dissolved in ethyl acetate, filtered over Celite, washed with ethyl acetate and concentrated again. The residue was dissolved in hot diisopropyl ether, filtered, washed with diisopropyl ether, and concentrated for 7 h in vacuo. Yield: 17.12 g (92%)
    • Preparation of (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)-methoxy)acetamide derivatives
  • Figure US20080153843A1-20080626-C00135
    • Example 127 (S)-2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
  • Step (a): Chlorosulfonic acid (7.3 ml, 110.13 mmol) in dichloromethane (60 ml) was slowly added dropwise, over a period of 10 min., to a solution, cooled to 0° C., of 3,5-dimethylanisole (3.1 g, 22.03 mmol) in dichloromethane (50 ml). The reaction mixture was stirred for a further 10 min. and then slowly added dropwise to ice-water (300 ml) and stirred until the ice had melted. The phases were separated, and the aqueous phase was extracted with dichloromethane (50 ml). The combined organic phases were washed with saturated sodium chloride solution (50 ml), dried (Na2SO4) and concentrated in vacuo. A solution of pentafluorophenol (4.1 g, 22.03 mmol) and triethylamine (6.1 ml, 44.05 mmol) in dichloromethane (50 ml) was stirred for 30 min. at room temperature. A solution of the sulfonyl chloride that had been prepared in dichloromethane (50 ml) was then slowly added dropwise. The reaction mixture was stirred for 1 h at room temperature. Saturated sodium hydrogen carbonate solution (50 ml) was added to the mixture, and the organic phase was washed with saturated sodium chloride solution (50 ml), dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) using hexane/diethyl ether/dichloromethane (20:1:2). Yield: 6.1 g (72%). [The undesired regioisomer was isolated in a yield of 14%.]
  • Step (b): Perfluorophenyl 4-methoxy-2,6-dimethylbenzenesulfonate (1.5 g, 3.92 mmol) and tetra-n-butylammonium chloride (2.18 g, 7.85 mmol) were added to a solution of the amino alcohol (S)-(1,2,3,4-tetrahydroisoquinolin-3-yl)methanol (960 mg, 5.89 mmol) in N,N-dimethylformamide (15 ml). The reaction mixture was heated for 1 h at 120° C. It was then concentrated in vacuo, and the residue was taken up in ethyl acetate (50 ml) and washed with 10% aqueous ammonium chloride solution (20 ml). The organic phase was dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) using hexane/diethyl ether/dichloromethane (3:2:2). Yield: 1.2 g (85%)
  • Step (c): tert-butyl 2-bromoacetate (1.02 ml, 6.07 mmol) was added at room temperature to a mixture of tetra-n-butylammonium hydrogen sulfate (113 mg, 0.332 mmol), aqueous sodium hydroxide solution (6.64 g, 165.98 mmol in water (7 ml)) and toluene (5 ml), and the mixture was then cooled to 0° C. A solution of (S)-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methanol (1.2 g, 3.32 mmol) in toluene (5 ml) was then added slowly. The reaction mixture was heated to room temperature and then stirred for 1 h at that temperature. The phases were separated, and the aqueous phase was extracted with diethyl ether (2×20 ml). The combined organic phases were washed with saturated sodium chloride solution (20 ml), dried (Na2SO4) and concentrated in vacuo. The crude product was used in the next step without being purified further. Yield: 1.79 g (>99%)
  • Step (d): (S)-tert-butyl 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)acetate (1.58 g, 3.32 mmol) was dissolved in tetrahydrofuran (10 ml), and sodium hydroxide solution (531 mg, 13.28 mmol in water (0.5 ml)) was added. The reaction mixture was refluxed for 2 h and then cooled to room temperature again, and water (20 ml) was added. The pH value of the aqueous phase was adjusted to pH 2 with 2 M hydrochloric acid, and extraction with ethyl acetate (3×20 ml) was carried out. The combined organic phases were dried (Na2SO4) and concentrated in vacuo. The crude product was used in the next step without being purified further. Yield: 580 mg (42%)
  • Step (e): 1-(1-methylpiperidin-4-yl)piperazine (65 mg, 0.358 mmol) and 4-methylmorpholine (0.117 ml, 1.073 mmol) were added to a solution of (S)-2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)acetic acid (150 mg, 0.358 mmol) in N,N-dimethylformamide (5 ml). Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (188 mg, 0.429 mmol) was added to the mixture, and stirring was carried out for 15 h at room temperature. The mixture was then concentrated in vacuo, the residue was taken up in ethyl acetate (20 ml) and saturated sodium hydrogen carbonate solution (10 ml), and the aqueous phase was extracted with ethyl acetate (20 ml). The combined organic phases were dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) using diethyl ether/dichloromethane/methanol/ammonia solution (25% aq.) (20:10:10:0.4). Yield: 90 mg (43%), orange oil; MS, m/z 595.2 (MH+).
    • Example 185 (S)-2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone
  • Step (e): N,N′-Carbonyldiimidazole (131 mg, 0.813 mmol) was added to a solution of (S)-2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-acetic acid (step d, Example 127) (325 mg, 0.775 mmol) in dichloromethane (5 ml), and stirring was carried out for 2 h at 30° C. A solution of 1-((1-methylpiperidin-4-yl)methyl)piperazine (152 mg, 0.775 mmol) in dichloromethane (5 ml) was then added at room temperature, and the reaction mixture was stirred for 15 h at that temperature. Saturated sodium hydrogen carbonate solution (10 ml) was added to the mixture, and the aqueous phase was extracted with dichloromethane (20 ml). The combined organic phases were dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) using ethyl acetate/methanol/ammonia solution (25% aq.) (40:10:0.5). Yield: 263 mg (57%); MS, m/z 599.3 (MH+).
  • The example compounds listed in the following table were prepared from the corresponding starting materials closely following the process described for Example 185. The progress of the reaction was monitored in each case by thin-layer chromatography and, on the basis thereof, the reaction times for analogous reactions were adapted accordingly. The reaction temperatures and the equivalent amounts of the reagents used can differ slightly in analogous reactions. The starting materials used are commercially available or were prepared in the manner described.
  • Yield (%)
    Example No. Amino alcohol Amine (R5R6NH) (over 5 steps) MS, m/z (MH+)
    1863 (S)-piperidin-2- 4-(piperidin-4-yloxy)pyridine 14 532.2
    ylmethanol4 dihydrochloride5
    187  (S)-(1, 2,3,4- 4-(2-(pyrrolidin-1-yl)ethyl)- 18 584.3
    tetrahydroisoquinolin- piperidine
    3-yl)methanol

    3 The hydrochloride precipitation was carried out from a methyl ethyl ketone solution of the free base, with addition of 2 M hydrogen chloride solution in diethyl ether (5 eq.).4 The (S)-amino alcohol used was prepared as follows: Hydrogen bromide-tetrahydrofuran complex (3 eq., 1 M solution in tetrahydrofuran) was added dropwise to a suspension, cooled to 0° C., of the carboxylic acid (1 eq.) in tetrahydrofuran (4 ml/mmol), and the mixture was then stirred for 1 h at room temperature. The reaction mixture was then refluxed for 4 h and stirred for a further 15 h at room temperature. The mixture was cooled to 0° C. and 3 M sodium hydroxide solution was added, and then refluxing was carried out for 6 h. The mixture was extracted with dichloromethane (4×), and the combined organic phases were dried (Na2SO4) and concentrated in vacuo. The crude product was used in the next synthesis step without being purified.5 The amine R5R6NH was prepared analogously to 3-(piperidin-4-yloxy)pyridine hydrochloride (used in the synthesis of Example compound 165) [analogous process see also: J. Chao et al., Tetrahedron Lett., 2007, 48, 791]
    • Reaction of substituted (S)-2-((2-(phenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-methoxy)acetic acid derivatives with amines (R5R6NH)
  • Figure US20080153843A1-20080626-C00136
    • Example 133 (S)-2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
  • The synthesis of this compound was for the most part carried out analogously to the synthesis described for Example 185. However, synthesis step (a) was omitted and synthesis step (b) was carried out as follows:
  • Step (b): Triethylamine (1.27 ml, 9.19 mmol) was added to a solution of (S)-(1,2,3,4-tetrahydroisoquinolin-3-yl)methanol (1.0 g, 6.13 mmol) in dichloromethane (10 ml), and the mixture was stirred for 5 min. at room temperature. A solution of 2,4-dichlorobenzene-1-sulfonyl chloride (1.35 g, 5.51 mmol) in dichloromethane (10 ml) was then added dropwise at 0° C. The reaction mixture was heated to room temperature and stirred for 1 h at that temperature. Saturated sodium hydrogen carbonate solution (20 ml) was then added to the mixture, and the aqueous phase was extracted with dichloromethane (30 ml). The combined organic phases were dried (Na2SO4) and concentrated in vacuo, and the crude product was then purified by column chromatography (silica gel) using hexane/diethyl ether/dichloromethane (1:1:1). Yield: 1.59 g (70%).
  • Synthesis steps (c) to (e) were carried out analogously to the processes described for Example 185. Example 133 (clear oil) was obtained in this manner in a yield of 85% over 3 steps. MS, m/z 585.3 (MH+)
  • The example compounds listed in the following table were prepared analogously to Example 133 from (S)-(1,2,3,4-tetrahydroisoquinolin-3-yl)methanol, the corresponding sulfonyl chloride (R1SO2Cl) and the corresponding amine (R5R6NH).
  • Sulfonyl chloride Amine Yield (%)
    Example No. (R1SO2Cl) (R5R6NH) (over 4 steps) MS, m/z (MH+)
    142 4-methoxybenzene-1- 1-(1-methyl- 62 557.2
    sulfonyl chloride piperidin-4-yl)-
    piperazine
    182 4-methoxybenzene-1- 4-(2-(pyrrolidin-1- 56 556.2
    sulfonyl chloride yl)ethyl)piperidine
    183 2,4-dichlorobenzene-1- 4-(2-(pyrrolidin-1- 20 594.1
    sulfonyl chloride yl)ethyl)piperidine
    184 2,4-dichlorobenzene-1- 1-((1-methyl- 28 609.2
    sulfonyl chloride piperidin-4-yl)-
    methyl)piperazine
     1896 4-methoxybenzene-1- 1-((1-methyl- 14 571.3
    sulfonyl chloride piperidin-4-yl)-
    methyl)piperazine
    6The corresponding base was converted into the corresponding dihydrochloride (2 × HCl) as follows: The free base was dissolved in a small amount of dichloromethane/diethyl ether (1:5); 2 M hydrogen chloride solution in diethyl ether (3 eq.) was added, and the resulting dihydrochloride was filtered off.
    • Example 135 (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)azetidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
  • Figure US20080153843A1-20080626-C00137
  • Step (i): tert-butyl 2-bromoacetate (0.799 ml, 5.45 mmol) was added at room temperature to a mixture of tetra-n-butylammonium hydrogen sulfate (122 mg, 0.363 mmol), aqueous sodium hydroxide solution (7.27 g, 181.7 mmol in water (7 ml)) and toluene (5 ml), and the mixture was then cooled to 0° C. A solution of (S)-tert-butyl 2-(hydroxymethyl)azetidine-1-carboxylate (680 mg, 3.63 mmol) in toluene (5 ml) was then added slowly. The reaction mixture was heated to room temperature and stirred for 1 h at that temperature. The phases were separated, and the aqueous phase was extracted with diethyl ether (2×20 ml). The combined organic phases were washed with saturated sodium chloride solution (20 ml), dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) using hexane/diethyl ether/dichloromethane (2:1:1). Yield: 910 mg (83%)
  • Step (ii): (S)-tert-butyl 2-((2-tert-butoxy-2-oxoethoxy)methyl)azetidine-1-carboxylate (890 mg, 2.95 mmol) was dissolved in tetrahydrofuran (10 ml), and sodium hydroxide (708 mg, 17.72 mmol in water (1 ml)) was added. The reaction mixture was refluxed for 2 h and then cooled to room temperature again, and water (20 ml) was added. The pH value of the aqueous phase was adjusted to pH 2 with 2 M hydrochloric acid, and extraction with ethyl acetate (3×20 ml) was carried out. The combined organic phases were dried (Na2SO4) and concentrated in vacuo. The crude product was used in the next synthesis step without being purified further. Yield: 700 mg (97%)
  • Step (iii): 1-(1-methylpiperidin-4-yl)piperazine (433 mg, 2.39 mmol) and 4-methylmorpholine (0.798 ml, 7.95 mmol) were added to a solution of (S)-2-((1-(tert-butoxycarbonyl)azetidin-2-yl)methoxy)acetic acid (650 mg, 2.65 mmol) in N,N-dimethylformamide (20 ml). Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (1.39 mg, 3.18 mmol) was added to the mixture, and stirring was carried out for 15 h at room temperature. The mixture was then concentrated in vacuo, the residue was taken up in ethyl acetate (20 ml) and saturated sodium hydrogen carbonate solution (10 ml), and the aqueous phase was extracted with ethyl acetate (2×20 ml). The combined organic phases were dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) using diethyl ether/dichloromethane/methanol/ammonia solution (25% aq.) (20:10:10:0.4). Yield: 580 mg (53%).
  • Step (iv): Hydrogen chloride (3.47 ml, 6.94 mmol, 2 M solution in diethyl ether) was added at room temperature to a solution of (S)-tert-butyl 2-((2-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-oxoethoxy)methyl)azetidine-1-carboxylate (570 mg, 1.39 mmol) in ethyl acetate/diethyl ether (2 ml; 2:5). The reaction mixture was stirred for 2 h at 40° C., and the resulting solid was filtered off and dried. Yield: 520 mg (89%)
  • Step (v): 1,8-diazabicyclo[5.4.0]-undec-7-ene (DBU) (0.15 ml, 0.993 mmol) and perfluoro-phenyl 4-methoxy-2,6-dimethylbenzenesulfonate (123 mg, 0.298 mmol) [for synthesis see Example 127]were added to a solution of (S)-2-(azetidin-2-ylmethoxy)-1-(4-(1-methyl-piperidin-4-yl)piperazin-1-yl)ethanone trihydrochloride (100 mg, 0.238 mmol) in tetrahydrofuran (10 ml). The reaction mixture was refluxed for 1 h and stirred for 3 d at room temperature. Then saturated sodium hydrogen carbonate solution (20 ml) and ethyl acetate (30 ml) were added to the mixture. The aqueous phase was extracted with ethyl acetate (2×15 ml), and the combined organic phases were washed with saturated sodium chloride solution (20 ml). The organic phase was then dried (Na2SO4) and concentrated in vacuo, and the crude product was then purified by column chromatography (silica gel) using diethyl ether/dichloromethane/methanol/ammonia solution (25% aq.) (20:10:10:0.4). Yield: 40 mg (33%), yellow resin; MS, m/z 509.3 (MH+).
    • Reaction of pyrrolidin-2-ylmethanol to substituted 2-((1-(phenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamides
  • Figure US20080153843A1-20080626-C00138
    • Example 140 (R)-2-((1-(4-methoxy-2,3,6-trimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
  • Step (i): tert-butyl 2-bromoacetate (2.19 ml, 14.91 mmol) was added at room temperature to a mixture of tetra-n-butylammonium hydrogen sulfate (334 mg, 0.994 mmol), aqueous sodium hydroxide solution (9.93 g, 248.43 mmol in water (10 ml)) and toluene (7.5 ml), and then the mixture was cooled to 0° C. A solution of the amino alcohol (R)-tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate (2.0 g, 9.94 mmol) in toluene (7.55 ml) was then added slowly. The reaction mixture was heated to room temperature and then stirred for 2 h at that temperature. The phases were separated, and the aqueous phase was extracted with diethyl ether (2×30 ml). The combined organic phases were washed with saturated sodium chloride solution (30 ml), dried (Na2SO4) and concentrated in vacuo. The crude product was filtered over silica gel using ethyl acetate and was used in the next step. Yield: 3.2 g (>99%).
  • Step (ii): (R)-tert-butyl 2-((2-tert-butoxy-2-oxoethoxy)methyl)pyrrolidine-1-carboxylate (3.2 g, 10.15 mmol) was dissolved in tetrahydrofuran (25 ml), and sodium hydroxide solution (2.44 g, 60.88 mmol in water (2.5 ml)) was added. The reaction mixture was refluxed for 2 h and then cooled to room temperature again, and water (20 ml) was added. The pH value of the aqueous phase was adjusted to pH 2 with 2 M hydrochloric acid, and extraction with ethyl acetate (3×30 ml) was carried out. The combined organic phases were dried (Na2SO4) and concentrated in vacuo. The crude product was used in the next synthesis step without being purified further. Yield: 2.0 g (76%)
  • Step (iii): N,N′-Carbonyldiimidazole (328 mg, 1.93 mmol) was added to a solution of (R)-2-((1-(tert-butoxycarbonyl)pyrrolidin-2-yl)methoxy)acetic acid (500 mg, 1.93 mmol) in dichloromethane (5 ml), and stirring was carried out for 30 min. at room temperature. A solution of 1-(1-methylpiperidin-4-yl)piperazine (353 mg, 1.93 mmol) in dichloromethane (5 ml) was then added at room temperature, and the reaction mixture was stirred for 15 h at that temperature. Saturated sodium hydrogen carbonate solution (10 ml) was then added to the mixture, and the aqueous phase was then extracted with dichloromethane (20 ml). The combined organic phases were dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) using diethyl ether/dichloromethane/methanol/ammonia solution (25% aq.) (20:10:10:0.4). Yield: 540 mg (66%)
  • Step (iv): Hydrogen chloride (6.24 ml, 12.48 mmol, 2 M solution in diethyl ether) was added at room temperature to a solution of (R)-tert-butyl 2-((2-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-oxoethoxy)methyl)pyrrolidine-1-carboxylate (530 mg, 1.25 mmol) in ethyl acetate/diethyl ether (30 ml; 1:2). The reaction mixture was stirred for 2 h at 40° C., and the resulting solid was filtered off and dried. Yield: 440 mg (81%)
  • Step (v): Triethylamine (0.172 ml, 1.25 mmol) was added to a solution of (R)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-(pyrrolidin-2-ylmethoxy)ethanone trihydrochloride (120 mg, 0.277 mmol) in dichloromethane (5 ml). A solution of 4-methoxy-2,3,6-trimethylbenzene-1-sulfonyl chloride10 (58 mg, 0.249 mmol) in dichloromethane (5 ml) was then added dropwise at 0° C. The reaction mixture was heated to room temperature and stirred for 3 d at that temperature. Saturated sodium hydrogen carbonate solution (5 ml) was added to the mixture, and the aqueous phase was extracted with dichloromethane (20 ml). The combined organic phases were dried (Na2SO4) and concentrated in vacuo, and the crude product was then purified by column chromatography (silica gel) using diethyl ether/dichloromethane/methanol/ammonia solution (25% aq.) (20:10:10:0.4). The crude product was dissolved in a small amount of dichloromethane/diethyl ether, and chlorotrimethylsilane (2.5 eq.) was added slowly. The resulting precipitate was filtered off and dried. Yield: 80 mg (47%), white solid; MS, m/z 537.2 (MH+).
  • The example compounds listed in the following table were prepared from the corresponding starting materials closely following the process described for Example 140. The progress of the reaction was in each case monitored by thin-layer chromatography and, on the basis thereof, the reaction times in analogous reactions were adapted accordingly. The reaction temperatures and equivalent amounts of the reagents used can differ in analogous reactions. The amount of triethylamine used in step (v) in each case was adapted according to the stoichiometry of the amine hydrochloride (×HCl) used. The starting materials used are commercially available or were prepared in the manner described.
  • MS,
    Amine Sulfonyl chloride Yield (%) m/z
    Example No. Amino alcohol (R5R6NH) (R1 SO2Cl) (over 5 steps) (MH+)
    1527 (R)-tert-butyl 2- 1-(1-methylpiperidin- 2-Chloro-6-methylbenz- 34 513.1
    (hydroxymethyl)pyrroli- 4-yl)piperazine 1-sulfonyl chloride
    dine-1-carboxylate
    1618 (S)-tert-butyl 2- 4-(2-(pyrrolidin-1- 2-Chloro-6-methylbenz- 27 512.1
    (hydroxymethyl)pyrroli- yl)ethyl)piperidine 1-sulfonyl chlorid
    dine-1-carboxylate
    1628 (S)-tert-butyl 2- 1-(1-methylpiperidin- 2-Chloro-6-methylbenz- 20 513.1
    (hydroxymethyl)pyrroli- 4-yl)piperazine 1-sulfonyl chloride
    dine-1-carboxylate
    1638 (S)-tert-butyl 2- 1-((1-methylpiperidin- 2-Chloro-6-methylbenz- 11 527.1
    (hydroxymethyl)pyrroli- 4-yl)methyl)- 1-sulfonyl chloride
    dine-1-carboxylate piperazine
    167  (S)-tert-butyl 2- 1-(1-methylpiperidin- 4-methoxy-2,6- 53 537.3
    (hydroxymethyl)piperi- 4-yl)piperazine dimethylbenzene-1-
    dine-1-carboxylate9 sulfonyl chloride10
    1778 (R)-tert-butyl 2- 1-(1-methylpiperidin- 4-methoxy-2,6- 16 537.3
    (hydroxymethyl)piperi- 4-yl)piperazine dimethylbenzene-1-
    dine-1-carboxylate9 sulfonyl chloride10
    180  (S)-tert-butyl 2- 1-(1-methylpiperidin- 4-methoxy-2,6- 10 523.2
    (hydroxymethyl)pyrroli- 4-yl)piperazine dimethylbenzene-1-
    dine-1-carboxylate sulfonyl chloride10
    181  (S)-tert-butyl 2- 4-(2-(pyrrolidin-1- 4-methoxy-2,6- 8 537.3
    (hydroxymethyl)pyrroli- yl)ethyl)piperidine dimethylbenzene-1-
    dine-1-carboxylate sulfonyl chloride10
    1908 (S)-tert-butyl 2- 1-((1-methylpiperidin- 4-methoxy-2,6- 20 522.3
    (hydroxymethyl)pyrroli- 4-yl)methyl)- dimethylbenzene-1-
    dine-1-carboxylate piperazine sulfonyl chloride10
    7The hydrochloride precipitation was carried out from a dichloromethane solution of the free base with addition of 2 M hydrogen chloride solution in diethyl ether (10 eq.).
    8The hydrochloride precipitation was carried out from a methyl ethyl ketone/(optional) diethyl ether solution of the free base with addition of 2 M hydrogen chloride solution in diethyl ether (3-5 eq.).
    9The Boc-protected (R)- or (S)-amino alcohol used was prepared as follows: Hydrogen bromide-tetrahydrofuran complex (1.5 eq., 1 M solution in tetrahydrofuran) was added dropwise to a solution, cooled to 0° C., of the Boc-protected carboxylic acid (1 eq.) in tetrahydrofuran (50 ml/mmol), and the mixture was then stirred for 3 h at room temperature. Water and potassium carbonate were added to the mixture, cooled to 0° C., and stirringwas carried out for 30 min. The aqueous phase was then extracted with diethyl ether (3×), and the combined organic phases were washed with saturated sodium chloride solution (1×) and then dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel). [see also Timothy J. Wilkinson et al.; Org. Lett.; 2000; 155-158]
    104-methoxy-2,6-dimethylbenzene-1-sulfonyl chloride was prepared as follows: Chlorosulfonic acid (5 eq.) in dichloromethane (25 ml/mmol) was slowly added dropwise over a period of 10 min. to a solution, cooled to 0° C., of 3,5-dimethylanisole (1 eq.) in dichloromethane (25 ml/mmol). The reaction mixture was stirred for a further 10 min. and then slowly added dropwise to ice-water and stirred until the ice had melted. The phases wereseparated, and the aqueous phase was extracted with dichloromethane. The combined organic phases were washed with saturated sodium chloride solution, dried (Na2SO4) and concentrated in vacuo. The crude product was used in the next synthesis step without being purified further.
    • Reaction of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-acetic acid (acid structural unit S27) with amines (R5R6NH)
  • Figure US20080153843A1-20080626-C00139
    • Example 201 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperidin-1-yl)ethanone
  • Diisopropylethylamine (2.5 eq.), followed by N-hydroxybenzotriazole (HOBt) (1 eq.) and N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI) (1.5 eq.) were added to a solution of the acid structural unit S27 (1 eq.) in dichloromethane (5 ml/mmol). The resulting reaction mixture was stirred for 15 min. at 25° C. Cooling to 0° C. was then carried out, and 4-(piperidin-4-yl)pyridine (1.2 eq.) was added. The mixture was stirred for 16 h at 25° C. until the reaction was complete. It was diluted with dichloromethane (30 ml) and extracted with saturated ammonium chloride solution, saturated sodium chloride solution, saturated sodium hydrogen carbonate solution and again with saturated sodium chloride solution. The organic phase was dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (2% methanol in dichloromethane). Yield: 40%; MS, m/z 516.2 (MH+).
  • The example compounds listed in the following table were prepared from the corresponding starting materials closely following the process described for Example 201. 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid (acid structural unit S27) was synthesized analogously to the process described for Examples 202 and 210 for the preparation of the corresponding carboxylic acid from the corresponding amino alcohol, 4-methoxy-2,6-dimethylbenzene-1-sulfonyl chloride being prepared analogously to the process described for Example 167 (except that 2 eq. of chlorosulfonic acid were used).
  • MS, m/z
    Example No. Amine (R5R6NH) Yield (%) (MH+)
    200 6-Fluoro-2-(piperidin-4-yl)-1,2,3,4- 50 588.2
    tetrahydroisoquinoline
     211* 2-(piperidin-4-yl)-1,2,3,4- 11 559.3
    tetrahydropyrrolo[1,2-a]pyrazine
    217 3-(piperidin-4-yl)pyridine 50 516.2
    *The reaction was carried out in N,N-dimethylformamide instead of dichloromethane.
    • Preparation of the Amines: 6-Fluoro-2-(piperidin-4-yl)-1,2,3,4-tetrahydroisoquinoline (Used in the Synthesis of Example Compound 200)
  • Figure US20080153843A1-20080626-C00140
  • Step (i): To a solution of tert-butyl 4-oxopiperidine-1-carboxylate (3.12 mmol) and 6-fluoro-1,2,3,4-tetrahydroisoquinoline (2.6 mmol) in methanol (15 ml) there was added, under nitrogen, at 25° C., a catalytic amount of acetic acid followed by sodium cyanoborohydride (2.5 eq.). The resulting solution was stirred for 16 h at that temperature until the reaction was complete (TLC monitoring). Ice was added to the reaction mixture, and concentration in vacuo was then carried out. The residue was taken up in dichloromethane (100 ml) and washed with saturated sodium bicarbonate solution and with saturated sodium chloride solution. The organic phase was dried (Na2SO4), filtered, and concentrated in vacuo. The crude product so obtained was used directly in the following synthesis step. Yield: 50%.
  • Step (ii): Trifluoroacetic acid (13 eq.) was added at 0° C. to a solution of tert-butyl 4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)piperidine-1-carboxylate (1 eq.) in dichloromethane (10 ml/mmol), and the reaction mixture was then stirred for 2 h at 25° C. The solvent was removed, and the crude product was dried in vacuo. The amine so obtained was reacted further without being purified.
    • 2-(piperidin-4-yl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (Used in the Synthesis of Example Compound 211)
  • Figure US20080153843A1-20080626-C00141
  • Step (i): Sodium hydroxide (9.4 g, 0.23 mol; powder) and tetrabutylammonium hydrogen sulfate (0.8 g, 2.36 mmol) were added to a solution of 1H-pyrrole (4 g, 0.06 mol) in acetonitrile (33 ml). The mixture was stirred for 30 min. at 25° C., and then 2-chloroethylamine hydrochloride (8.2 g, 0.07 mol) was added. The reaction mixture was refluxed for 24 h, the solid was filtered off, and the filtrate was concentrated in vacuo. The crude product was purified by distillation in vacuo. Yield: 30%
  • Step (ii): Trifluoroacetic acid (0.5 ml) was added to a solution of 1-(2-aminoethyl)pyrrole (9 mmol) and 37% aqueous formaldehyde solution (9 mmol) in ethanol (20 ml), and the resulting reaction mixture was stirred for 15 min. at 50° C. It was then cooled to 25° C. and stirred for a further 4 h at that temperature. The solvent was removed in vacuo, and the residue was taken up in ethyl acetate, rendered basic with aqueous sodium carbonate solution. The organic phase was dried (Na2SO4) and concentrated. The crude product was used in the next synthesis step without being purified further. Yield: 40%.
  • Step (iii): To a solution of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (4.68 mmol) and 1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine (3.9 mmol) in methanol (15 ml) there was added, under nitrogen, at 25° C., a catalytic amount of acetic acid, followed by sodium cyanoborohydride (2.5 eq.). The resulting solution was stirred for 16 h at that temperature until the reaction was complete (TLC monitoring). Ice was added to the reaction mixture, and then concentration in vacuo was carried out. The residue was taken up in dichloromethane (100 ml) and washed with saturated sodium bicarbonate solution and with saturated sodium chloride solution. The organic phase was dried (Na2SO4), filtered, and concentrated in vacuo. The crude product so obtained was used directly in the following synthesis step. Yield: 40%.
  • Step (iv): A solution of tert-butyl 4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)piperidine-1-carboxylate (1.8 mmol) and hydrogen chloride in ethyl acetate (30 ml, saturated solution) was stirred for 2 h at room temperature until the reaction was complete (TLC monitoring). The solvent was removed, and the crude product was dried in vacuo. The amine so obtained was used in the next synthesis step without being purified further.
    • 3-(piperidin-4-yl)pyridine (Used in the Synthesis of Example Compound 217)
  • Figure US20080153843A1-20080626-C00142
  • Step (i): n-butyllithium (2 eq.) was added dropwise over a period of 2 hours at −78° C. to a solution of 3-bromopyridine (1 eq.) in dry tetrahydrofuran (250 ml). The reaction mixture was then stirred for 1 h at −78° C. N-benzyl-piperidone (3 g, in 50 ml of tetrahydrofuran) was slowly added dropwise to the solution over a period of 30 min. at −78° C. The reaction mixture was stirred for 1 h at −78° C., and the progress of the reaction was monitored by thin-layer chromatography. When the reaction was complete, water was added and extraction with ethyl acetate (3×100 ml) was carried out. The combined organic phases were dried (Na2SO4), filtered, and concentrated in vacuo. The crude product was purified by column chromatography (4% methanol in dichloromethane). Yield: 20%.
  • Step (ii): 80% sulfuric acid was added dropwise at 0° C. to a solution of 1-benzyl-4-(pyridin-3-yl)piperidin-4-ol (1 g) in methanol (10 ml). The reaction mixture was maintained for 4 d at 90° C., and the progress of the reaction was monitored by thin-layer chromatography. When the reaction was complete, excess methanol was removed and the mixture was then adjusted to pH 14 by addition of sodium hydroxide solution and extracted with dichloro-methane (4×100 ml). The organic phase was dried (Na2SO4), filtered, and concentrated in vacuo. The crude product so obtained was used directly in the next synthesis step. Yield: quantitative.
  • Step (iii): 10% Pd/C (600 mg) was added, under argon, to a solution of 3-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)pyridine (950 mg) in methanol (10 ml), and the resulting mixture was stirred for 16 h at 23° C. under a hydrogen atmosphere. The progress of the reaction was monitored by LC-MS analysis and, when the reaction was complete, the mixture was filtered over Celite and washed with methanol. The filtrate was concentrated in vacuo, and the crude product was used directly in the next synthesis step. Yield: quantitative
  • Step (iv): To a solution of 3-(1-benzylpiperidin-4-yl)pyridine (650 mg) in methanol (10 ml) there was added, under argon, Pd(OH)2 (600 mg), followed by a catalytic amount of acetic acid. The resulting mixture was stirred for 16 h at 23° C. under a hydrogen atmosphere. The progress of the reaction was monitored by LC-MS analysis and, when the reaction was complete, the mixture was filtered over Celite and washed with methanol. The filtrate was concentrated in vacuo, and the crude product was used directly in the following synthesis step. Yield: quantitative
    • Example 215 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(6-(4-methyl-piperazin-1-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone
  • Figure US20080153843A1-20080626-C00143
  • Step (i): To a solution of the acid structural unit S27 (1.5 g) in dichloromethane (5 ml/mmol) there was added at 0° C. diisopropylethylamine (2.5 eq.), followed by N-hydroxybenzotriazole (HOBt) (1 eq.) and N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI) (1.5 eq.). The resulting reaction mixture was stirred for 15 min. at 23° C. It was then cooled to 0° C., and 6-bromo-1,2,3,4-tetrahydroisoquinoline (1.2 eq., dissolved in dichloromethane) was added dropwise. The reaction mixture was stirred for 16 h at 25° C. until the reaction was complete. The mixture was diluted with dichloromethane (100 ml) and extracted with saturated ammonium chloride solution, saturated sodium chloride solution, saturated sodium hydrogen carbonate solution and again with saturated sodium chloride solution. The organic phase was dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (5% ethyl acetate in dichloromethane). Yield: 80%
  • Step (ii): Cesium carbonate (2.5 eq.) was added to a solution of N-methylpiperazine (3.6 mmol) and 1-(6-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2-((1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)piperidin-2-yl)methoxy)ethanone (3 mmol) in dioxane (20 ml), and the resulting solution was degassed for 30 min. with argon. Xanthphos (2 mmol), followed by palladium tris(dibenzylideneacetone)dipalladium (0.15 mmol) were then added, under argon, and the mixture was heated for 16 h at 120° C. The progress of the reaction was monitored by thin-layer chromatography. The reaction mixture was filtered and washed with ethyl acetate, and the filtrate was concentrated in vacuo. The crude product was taken up in dichloromethane and washed with water and saturated sodium chloride solution. The organic phase was dried (Na2SO4), filtered, and concentrated in vacuo. The product was purified by column chromatography (4% methanol in dichloromethane). Yield: 10%; MS, m/z 585.3 (MH+).
    • Preparation of substituted 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)acetic acid derivatives
  • Figure US20080153843A1-20080626-C00144
    • Example 202 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
  • Step (i): 1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester (25 mmol) in tetrahydrofuran (5 ml/mol) was added dropwise at 0° C. to a suspension of lithium aluminium hydride (2 eq.) in tetrahydrofuran (50 ml). The reaction mixture was stirred for 1 h at 25° C. and then refluxed for 4 h. The progress of the reaction was monitored by thin-layer chromatography. Saturated sodium sulfate solution was added to the reaction mixture, and the mixture was then filtered over Celite and washed with ethyl acetate. The filtrate was concentrated in vacuo and the crude product was purified by column chromatography (3:7 ethyl acetate/hexane). Yield: 50%
  • Step (ii): To a solution of (1,2,3,4-tetrahydro-quinolin-2-yl)-methanol (0.67 mmol) in dichloromethane (5 ml) there was added at 0° C. pyridine (5 eq.) followed by a catalytic amount of dimethylaminopyridine (0.01 eq.). 4-methoxy-2,6-dimethyl-benzenesulfonyl chloride (1.2 eq.) in dichloromethane (2 ml) was then added dropwise. The reaction mixture was stirred for 1 h at 25° C. until the reaction was complete (TLC monitoring) and then diluted with dichloromethane (50 ml) and washed with saturated copper sulfate solution (4×15 ml) and saturated sodium chloride solution. The organic phase was dried (Na2SO4), filtered, and concentrated in vacuo. The crude product was purified by column chromatography (5% ethyl acetate in dichloromethane).
  • [4-methoxy-2,6-dimethylbenzene-1-sulfonyl chloride was prepared analogously to the process described for Example 167 (except that 2 eq. of chlorosulfonic acid were used).] Yield: 75%
  • Step (iii): Tetrabutylammonium chloride (0.33 eq.) and 35% sodium hydroxide solution (3 ml) were added at 0° C. to a cold solution of (1-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol (0.47 mmol) in toluene (3 ml). tert-butyl bromoacetate (1.5 eq.) was added dropwise at 0° C. to this cold reaction mixture. The mixture was then stirred for 90 min. at 25° C. until the reaction was complete (TLC monitoring). The mixture was extracted with ethyl acetate (50 ml), and the organic phase was washed with water until the pH value was neutral. Extraction with saturated sodium chloride solution was then carried out, and the organic phase was dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (20% ethyl acetate in hexane). Yield: 66%
  • Step (iv): Trifluoroacetic acid (13 eq.) was added at 0° C. to a solution of tert-butyl 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)acetate (1 eq.) in dichloormethane (10 ml/mmol), and the mixture was stirred for 2 h at 25° C. The reaction mixture was then concentrated in vacuo, and the crude product was used in the next synthesis step without being purified further.
  • Step (v): To a solution of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydro-quinolin-2-yl)methoxy)acetic acid (1 eq.) in dichloromethane (5 ml/mmol) there was added at 0° C. diisopropylethylamine (2.5 eq.), followed by N-hydroxybenzotriazole (HOBt) (1 eq.) and N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI) (1.5 eq.). The resulting reaction mixture was stirred for 15 min. at 25° C. It was then cooled to 0° C., and 1-(1-methylpiperidin-4-yl)piperazine (1.2 eq.) was added. The reaction mixture was stirred for 16 h at 25° C. until the reaction was complete. It was diluted with dichloromethane (30 ml) and extracted with saturated ammonium chloride solution, saturated sodium chloride solution, saturated sodium hydrogen carbonate solution and again with saturated sodium chloride solution. The organic phase was dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (2% methanol in dichloromethane). Yield: 60%; MS, m/z 585.3 (MH+)
  • The example compounds listed in the following table were prepared from the corresponding sulfonyl chlorides closely following the process described for Example 202 (step (v)).
  • Yield (%) MS, m/z
    Example No. Sulfonyl chloride (R1SO2Cl) (over 5 steps) (MH+)
    203 Naphthalene-2-sulfonyl 18 577.2
    chloride
    204 4-methoxybenzene-1- 10 557.2
    sulfonyl chloride
    • Example 210 2-((1-(6-methoxynaphthalen-2-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methyl-piperidin-4-yl)piperazin-1-yl)ethanone
  • Figure US20080153843A1-20080626-C00145
  • Step (i): Sodium hydroxide (0.7 g) was added to a solution of sodium 6-hydroxynaphthalene-2-sulfonate (9 mmol) in water (20 ml). To this solution there was added over a period of 1 h at 50-55° C. dimethyl sulfate (1.1 eq.), followed by sodium chloride (3.3 g). The solid was filtered off and washed with saturated sodium chloride solution and toluene. The crude product was then dried. Yield: 75%.
  • Step (ii): Thionyl chloride (0.25 ml) was added at 0° C., under nitrogen, to a solution of sodium 6-methoxynaphthalene-2-sulfonate (2 mmol) in dry N,N-dimethylformamide (1 ml). The reaction mixture was stirred for 3 h at 0° C., and then ice-water (20 ml) was added thereto. The solid was filtered off and washed with cold water. The solid was then taken up in dichloromethane (25 ml), dried (Na2SO4) and concentrated in vacuo. Yield: 75%
  • Step (iii): Triethylamine (2.5 eq.) was added to a cold solution of piperidin-2-ylmethanol
  • (1.5 mmol) in dichloromethane (10 ml). A solution of 6-methoxynaphthalene-2-sulfonyl chloride (1.5 mmol) in dichloromethane (5 ml) was then added dropwise, and the mixture was stirred for 90 min. at 25° C. until the reaction was complete (TLC monitoring). Dichloromethane (100 ml) was added to the reaction mixture, and extraction with water was carried out. The organic phase was dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (5% methanol in dichloromethane). Yield: 50%
  • Step (iv): Tetrabutylammonium chloride (0.33 eq.) and 35% sodium hydroxide solution (4.5 ml) were added at 0° C. to a cold solution of (1-(6-methoxynaphthalen-2-ylsulfonyl)-piperidin-2-yl)methanol (0.75 mmol) in toluene (4.5 ml). tert-butyl bromoacetate (1.5 eq.) was added dropwise at 0° C. to this cold reaction mixture. The mixture was then stirred for 90 min. at 25° C. until the reaction was complete (TLC monitoring). The mixture was extracted with ethyl acetate (100 ml), and the organic phase was washed with water until the pH value was neutral. Extraction with saturated sodium chloride solution was then carried out, and the organic phase was dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (50% ethyl acetate in hexane). Yield: 90%.
  • Step (v): Trifluoroacetic acid (13 eq.) was added at 0° C. to a solution of tert-butyl 2-((1-(6-methoxynaphthalen-2-ylsulfonyl)piperidin-2-yl)methoxy)acetate (1 eq.) in dichloromethane (10 ml/mmol), and the mixture was stirred for 2 h at 25° C. The reaction mixture was then concentrated in vacuo, and the crude product was used in the following synthesis step without being purified further.
  • Step (vi): To a solution of 2-((1-(6-methoxynaphthalen-2-ylsulfonyl)piperidin-2-yl)methoxy)-acetic acid (1 eq.) in dichloromethane (5 ml/mmol) there was added at 0° C. diisopropylethylamine (2.5 eq.), followed by N-hydroxybenzotriazole (HOBt) (1 eq.) and N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI) (1.5 eq.). The resulting reaction mixture was stirred for 15 min. at 25° C. It was then cooled to 0° C., and 1-(1-methylpiperidin-4-yl)piperazine (1.2 eq.) was added. The reaction mixture was stirred for 16 h at 25° C. until the reaction was complete. It was diluted with dichloromethane (100 ml) and extracted with saturated ammonium chloride solution, saturated sodium chloride solution, saturated sodium hydrogen carbonate solution and again with saturated sodium chloride solution. The organic phase was dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (2% methanol in dichloromethane). Yield: 50%; MS, m/z 559.3 (MH+)
    • Examples 121-126 and 148-150
  • Figure US20080153843A1-20080626-C00146
    • AAV 1: Sulfonylation
  • Five equivalents of the corresponding amino alcohol are dissolved in dichloromethane (about 1.5 ml/mmol), and the corresponding sulfonyl chloride (1 equivalent) dissolved in dichloromethane (about 1.5 ml/mmol) is added at room temperature. When the sulfonyl chloride has dissolved completely (TLC monitoring), the batch is washed 3 times with 5% HCl. The organic phase is dried over sodium sulfate and concentrated to dryness in vacuo.
    • AAV 2: Etherification
  • The corresponding alcohol (1 equivalent) is dissolved in THF (about 5.5 ml/mmol) and cooled to 0° C., and sodium hydride (1.2 equivalents) is added in portions. The reaction mixture is stirred for 15 min. at 0° C. before tert-butyl bromoacetate (2.5 equivalents) is added. The reaction mixture is stirred for 16 hours at room temperature. For working up, the batch is quenched with saturated ammonium chloride solution, the aqueous phase is extracted twice with ethyl acetate, and the combined organic phases are washed with saturated sodium hydrogen carbonate solution and saturated sodium chloride solution. The organic phase is dried over sodium sulfate and concentrated to dryness in vacuo, and the residue is purified by column chromatography.
    • AAV 3: Tert-Butyl Ester Cleavage
  • The corresponding tert-butyl ester is dissolved in dichloromethane (about 15 ml/mmol), and trifluoroacetic acid (about 3.25 ml/mmol) is added at room temperature. The reaction mixture is stirred at room temperature until the tert-butyl ester has reacted completely (TLC monitoring) and is then concentrated to dryness in vacuo. Finally, toluene is added 3 times to the residue, and concentration to dryness is carried out.
    • AAV 4: Amine Coupling
  • The corresponding carboxylic acid (1 equivalent) is dissolved in dichloromethane (about 8 ml/mmol); 1,1′-carbonyldiimidazole (about 1.05 equivalents) is added, and stirring is carried out for 1 hour at room temperature. The corresponding amine (1 equivalent), dissolved in dichloromethane (about 8 ml/mmol), is then added, and the reaction mixture is stirred for 16 hours at room temperature. For working up, the batch is washed 3 times with saturated ammonium chloride solution and 3× with saturated sodium hydrogen carbonate solution, the organic phase is dried over sodium sulfate, and finally concentration to dryness in vacuo is carried out.
    • Acid Structural Units (I) (AAV 1-AAV 3): (Ia) 2-((1-(4-bromophenylsulfonyl)piperidin-2-yl)methoxy)acetic acid
  • According to AAV 1,4-bromobenzene-1-sulfonyl chloride (58.7 mmol) was reacted with 2-(hydroxymethyl)-piperidine in 77% yield to form (1-(4-bromophenylsulfonyl)piperidin-2-yl)-methanol. This was reacted further according to AAV2, yielding tert-butyl 2-((1-(4-bromo-phenylsulfonyl)piperidin-2-yl)methoxy)acetate in a yield of 38% (17.3 mmol). Finally, tert-butyl ester cleavage according to MV 3 yielded 2-((1-(4-bromophenylsulfonyl)piperidin-2-yl)methoxy)acetic acid without losses.
    • (Ib) 2-((1-(3-bromophenylsulfonyl)piperidin-2-yl)methoxy)acetic acid
  • According to AAV 1,3-bromobenzene-1-sulfonyl chloride (58.7 mmol) was reacted with 2-(hydroxymethyl)-piperidine in 80% yield to form (1-(4-bromophenylsulfonyl)piperidin-2-yl)-methanol. This was reacted further according to AAV2, yielding tert-butyl 2-((1-(3-bromo-phenylsulfonyl)piperidin-2-yl)methoxy)acetate in a yield of 31% (14.9 mmol). Finally, tert-butyl ester cleavage according to MV 3 yielded 2-((1-(3-bromophenylsulfonyl)piperidin-2-yl)methoxy)acetic acid without losses.
    • (Ic) (1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methanol
  • 4-bromo-2,6-dimethylbenzene-1-sulfonyl chloride: A solution of 42 g of sodium nitrite in 150 ml of water is added to a mixture, cooled to −5° C., of 200 ml of 48% HBr and 50 g of 3,5-dimethylaniline. The reaction mixture is stirred for 1 hour at from −5° C. to 0° C. Finally, this reaction mixture is slowly added to a mixture, heated to 80° C., of 88.3 g of copper(I) bromide and 150 ml of 48% HBr. The reaction mixture is stirred for 2 hours at 80° C. and observed by TLC monitoring (silica; hexane). When the reaction is complete, the product is obtained by water-vapour distillation and is purified by column chromatography (silica; hexane). In this manner, 1-bromo-3,5-dimethylbenzene was obtained in a yield of 60% (30 g).
  • The bromide obtained above, dissolved in 150 ml of dichloromethane, was added dropwise at 0° C., in the course of 20 minutes, to 90 ml of chlorosulfonic acid. When the addition is complete, stirring is carried out for 1 hour at room temperature. The progress of the reaction is monitored by means of TLC (hexane). When the reaction is complete, the reaction mixture is agitated on ice and extracted 3× with dichloromethane (200 ml each time). The combined organic phases are dried over Na2SO4, concentrated in vacuo and purified by column chromatography (silica; hexane). The desired 4-bromo-2,6-dimethylbenzene-1-sulfonyl chloride was obtained in a yield of 65% (29.8 g).
  • (1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methanol: Potassium carbonate is added to a solution of (1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methanol (22.5 g) in dichloromethane (290 ml), and the mixture is cooled to 0° C. A suspension of the hydrochloride of piperidin-2-ylmethanol (39 g, commercially available, CAS No.: 3433372) in dichloromethane (300 ml) was added to the sulfonyl chloride suspension in the course of 45 minutes at 0° C. When the addition was complete, the reaction mixture was stirred for 12 hours at room temperature. The progress of the reaction was monitored by thin-layer chromatography (silica; 10% EtOAc/heptane). When the reaction was complete, filtration was carried out, followed by washing with water and drying over Na2SO4. The solvent was removed in vacuo, and the crude product was purified by column chromatography (silica; 10% EtOAc/hexane). (1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methanol was obtained in a yield of 61.2% (30 g).
  • tert-butyl 2-((1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetate: 180 ml of 50% sodium hydroxy solution and 180 ml of tert-butyl bromoacetate were added to a solution of 18 g of (1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methanol, and stirring was carried for 10 minutes. 1.815 g of tetra-n-butylammonium hydrogen sulfate were then added, and stirring was carried out for a further 45 minutes at room temperature. The progress of the reaction was monitored by thin-layer chromatography (20% EtOAc/hexane). When the reaction was complete, 400 ml of ethyl acetate were added, and the phases were separated. The organic phase was washed with saturated sodium chloride solution, dried over sodium sulfate and concentrated in vacuo. The crude product was purified by column chromatography (silica; 5% EtOAc/hexane). tert-butyl 2-((1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetate was obtained in a yield of 78.2% (18 g).
  • The tert-butyl ester cleavage of 40 g of 2-((1-(4-bromo-2,6-dimethylphenylsulfonyl)-piperidin-2-yl)methoxy)acetate according to AAV 3 resulted in 2-((1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid in a yield of 76%.
    • Example No. 121 2-((1-(3-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)-piperazin-1-yl)ethanone
  • Acid structural unit (Ib) (6.4 mmol) was reacted according to AAV4 with 1-(1-methyl-4-piperidinyl)piperazine. The desired product was obtained in a yield of 57%. HPLC-MS, m/z 557.2 (MH+)
    • Example No. 122 2-((1-(3-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
  • Acid structural unit (Ib) (4 mmol) was reacted according to AAV4 with 1-(4-pyridyl)piperazine. The desired product was obtained in a yield of 97%. HPLC-MS, m/z 537.1 (MH+)
    • Example No. 123 2-((1-(4-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)-piperazin-1-yl)ethanone
  • Acid structural unit (Ia) (7.6 mmol) was reacted according to AAV4 with 1-(1-methyl-4-piperidinyl)piperazine. The desired product was obtained in a yield of 73%. HPLC-MS, m/z 557.2 (MH+)
    • Example No. 124 2-((1-(3-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)-piperidin-1-yl)ethanone
  • Acid structural unit (Ib) (5 mmol) was reacted according to AAV4 with 4-(2-pyrrolidinoethyl)piperidine. The desired product was obtained in a yield of 69%. HPLC-MS, m/z 556.2 (MH+)
    • Example No. 125 2-((1-(4-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)-piperidin-1-yl)ethanone
  • Acid structural unit (Ia) (7.6 mmol) was reacted according to AAV4 with 4-(2-pyrrolidinoethyl)piperidine. The desired product was obtained in a yield of 71%. HPLC-MS, m/z 556.2 (MH+)
    • Example No. 126 2-((1-(4-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
  • Acid structural unit (Ia) (5 mmol) was reacted according to AAV4 with 1-(4-pyridyl)piperazine. The desired product was obtained in a yield of 70%. HPLC-MS, m/z 537.1 (MH+)
    • Example No. 148 2-((1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methyl-piperidin-4-yl)piperazin-1-yl)ethanone
  • Acid structural unit (Ic) (7.1 mmol) was reacted according to AAV4 with 1-(1-methyl-4-piperidinyl)piperazine. The desired product was obtained in a yield of 70%. HPLC-MS, m/z 585.1 (MH+)
    • Example No. 149 2-((1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
  • Acid structural unit (Ic) (7.1 mmol) was reacted according to AAV4 with 4-(2-pyrrolidionoethyl)-piperidine. The desired product was obtained in a yield of 70%. HPLC-MS, m/z 584.0 (MH+)
    • Example No. 150 2-((1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)-piperazin-1-yl)ethanone
  • Acid structural unit (Ic) (7.1 mmol) was reacted according to AAV4 with 1-(4-pyridyl)piperazine. The desired product was obtained in a yield of 79%. HPLC-MS, m/z 565.0 (MH+)
    • Preparation of the Sulfonyl Chlorides: Preparation of 2-methylnaphthalene-1-sulfonyl chloride
  • Figure US20080153843A1-20080626-C00147
    • Step A:
  • Commercially available 1-naphthylsulfonyl chloride (21.5 g) was added in portions at −5° C. to a mixture of 2-propanol (7.3 ml) and pyridine (25 ml). The reaction mixture was stirred for 15 h at 0° C. For working up, DCM (75 ml) and 1 M HCl (75 ml) were added at that temperature, and the organic phase was separated off. The aqueous phase was extracted with DCM (3×75 ml), and the combined organic phases were washed with 1 M HCl (2×50 ml) and sat. NaCl solution (50 ml). After drying over MgSO4, complete concentration was carried out and the desired product was obtained in the required purity. 22.8 g, 96%.
    • Step B:
  • The title compound from step A (18.6 g) was dissolved in THF (190 ml), and the mixture was cooled to −78° C. under a protecting gas atmosphere. Then 1.6 M n-BuLi in n-hexane (51 ml) was added sufficiently slowly that the temperature did not rise above −70° C. The reaction mixture was stirred for 2 h at −70° C., and then MeI (9.7 ml) was added. The reaction mixture was allowed to warm to 0° C. and was stirred for 3 h at that temperature. For working up, sat. NH4Cl (80 ml) was added at that temperature, and then the mixture was diluted with EtOAc (500 ml). The organic phase was separated off and the aqueous phase was extracted with EtOAc (2×120 ml), and the combined organic phases were washed with water (50 ml) and sat. NaCl solution (50 ml). After drying over MgSO4, complete concentration was carried out, and the residue was purified by column chromatography on silica gel (hexane/EtOAc). The desired product was obtained. 12.4 g, 63%.
    • Step C:
  • The title compound from step B (0.8 g) was suspended in 4 M HCl (31 ml), and the mixture was heated for 1-2 h at 110° C. It was then cooled to room temperature over a period of 15 h and concentrated completely; the residue obtained after coevaporation twice with DCM (2×30 ml) was dried under a high vacuum. The product so obtained was used in the next step without being purified further. 0.47 g, 70%.
    • Step D:
  • The title compound from step C (0.46 g) was suspended in toluene (2.2 ml), and SOCl2 (0.75 ml) and DMF (0.010 ml) were added to the resulting mixture. Heating was then carried out for 1 h at 90° C. until a solution was present. The solution was concentrated completely, and the residue was dried under a high vacuum. The product so obtained was used in the next step without being purified further.
    • Preparation of 2-chloronaphthalene-1-sulfonic acid
  • Figure US20080153843A1-20080626-C00148
    • Step A:
  • The title compound from the preparation of 2-methylnaphthalene-1-sulfonyl chloride, step A (20 g) was dissolved in THF (213 ml), and the mixture was cooled to −78° C. under a protecting gas atmosphere. Then 1.6 M n-BuLi in n-hexane (55 ml) was added sufficiently slowly that the temperature did not rise above −70° C. The reaction mixture was stirred for 2 h at −70° C., and then hexachloroethane (21 g) was added. The reaction mixture was allowed to warm to 0° C. and was stirred for 15 h at that temperature. For working up, sat. NH4Cl (100 ml) was added at that temperature, and then the mixture was diluted with EtOAc (350 ml). The organic phase was separated off and the aqueous phase was extracted with EtOAc (2×120 ml), and the combined organic phases were washed with water (50 ml) and sat. NaCl solution (50 ml). After drying over MgSO4, complete concentration was carried out, and the residue was purified by column chromatography on silica gel (hexane/EtOAc). The desired product was obtained. 19.8 g, 87%.
    • Step B:
  • The title compound from step A (3 g) was dissolved in EtOH (15.4 ml), and TFA (0.04 ml) was added. The resulting solution was refluxed for 5 h. After cooling, the mixture was concentrated and the residue was dissolved in DCM (20 ml) and washed with water (10 ml). After drying over MgSO4, complete concentration was carried out. The resulting product was used in the next step without being purified further. 2.2 g, 87%.
    • Preparation of 4-methoxynaphthalene-1-sulfonic acid
  • Figure US20080153843A1-20080626-C00149
    • Step A:
  • Commercially available sodium 4-methoxynaphthyl-1-sulfonate (2.5 g) was added at RT to a mixture of water (5.2 ml) and conc. HCl (22 ml). The mixture was extracted several times with MeOH/EtOAc 1:15 (a total of 400 ml), and the combined organic phases were washed with sat. NaCl solution (50 ml). After drying over MgSO4, complete concentration was carried out. The resulting product was used in the next step without being purified further. 1.2 g, 52%.
  • The preparation of the following examples was carried out closely following the process described for 2-methylnaphthalene-1-sulfonyl chloride, except that the sulfonic acids mentioned in the following table were used.
  • Sulfonic acid Sulfonyl chloride
    Figure US20080153843A1-20080626-C00150
    Figure US20080153843A1-20080626-C00151
    Figure US20080153843A1-20080626-C00152
    Figure US20080153843A1-20080626-C00153
    • Example 179
  • Figure US20080153843A1-20080626-C00154
    • Step A:
  • Commercially available 1,2,3,4-tetrahydronaphthalene (50 ml) was placed in chloroform (110 ml). At from −5 to −10° C., chlorosulfonic acid (73 ml) was added dropwise, with stirring, in the course of 30 min. The cooling was removed, and the solution was heated to RT in the course of 1 h. The reaction solution was poured onto ice, and the organic phase was separated off. The aqueous phase is extracted with DCM/MeOH 9:1 (3×150 ml), and the combined organic phases are washed with ice-water (2×50 ml). After drying over MgSO4, complete concentration was carried out, and the residue was purified by column chromatography on silica gel (hexane/EtOAc). The desired product is obtained. 8.4 g, 10%.
    • Step B:
  • The title compound from Example 107, step 4 (1.0 g) was placed in DCM (19 ml); cooling to 0° C. was carried out, and Et3N (1.8 ml) was added. The title compound from step A (0.5 g) was then added rapidly at that temperature. Stirring was carried out at RT until TLC monitoring indicated that the reaction was complete. For working up, NH4Cl solution (10 ml) and water (10 ml) were added, and the organic phase was separated off. The aqueous phase was extracted with DCM (3×15 ml), and the combined organic phases were washed with water (10 ml) and sat. NaCl solution (10 ml). After drying over MgSO4, complete concentration was carried out, and the residue was purified by column chromatography on silica gel (DCM/MeOH/NH3). 638 mg of the base were obtained, which was precipitated from acetone (10 ml)/ether (10 ml) by addition of H2O (21 μl) and TMSCl (302 μL). 598 mg, 46%, 533 (MH+).
  • Examples 157, 160, 173-176 and 191 were prepared closely following the process described for Example 179, except that the sulfonyl chlorides and amines mentioned in the following table were used. The preparation of sulfonyl chlorides that are not commercially available was carried out as described above.
  • Yield MS
    No. Sulfonyl chloride Amine (%) (MH+)
    157
    Figure US20080153843A1-20080626-C00155
    Figure US20080153843A1-20080626-C00156
         		8 543
    191
    Figure US20080153843A1-20080626-C00157
    Figure US20080153843A1-20080626-C00158
         		27 563
    174
    Figure US20080153843A1-20080626-C00159
    Figure US20080153843A1-20080626-C00160
         		30 559
    176
    Figure US20080153843A1-20080626-C00161
    Figure US20080153843A1-20080626-C00162
         		57 530
    175
    Figure US20080153843A1-20080626-C00163
    Figure US20080153843A1-20080626-C00164
         		3 530
    173
    Figure US20080153843A1-20080626-C00165
    Figure US20080153843A1-20080626-C00166
         		61 547
    160
    Figure US20080153843A1-20080626-C00167
    Figure US20080153843A1-20080626-C00168
         		69 627
    • Example 192 Preparation of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
  • Figure US20080153843A1-20080626-C00169
  • A suspension of the acid (500 mg, 1.4 mmol), amine (256 mg, 1.4 mmol) and HOAt (19 mg, 0.14 mmol) in CH2Cl2 (10 ml) was cooled to 0° C. After addition of EDCI (296 mg, 1.54 mmol), the reaction mixture was stirred for 30 min. at 0° C. and overnight at RT under a nitrogen atmosphere. After addition of CH2Cl2 (20 ml), the organic phase was extracted with aqueous saturated NaHCO3 solution (30 ml), and then the aqueous phase was separated off and extracted with CH2Cl2 (15 ml). The combined organic phases were dried over Na2SO4. After filtration and removal of the solvent in vacuo, the product was purified by column chromatography (silica, CH2Cl2/(7 M NH3 in methanol) 4/6-93/7). Yield: 331 mg, 45%.
    • Example 208 Preparation of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(3-(pyridin-3-ylmethyl)pyrrolidin-1-yl)ethanone
  • Figure US20080153843A1-20080626-C00170
  • EDCI (402 mg, 2.1 mmol) was added to a solution of the acid (520 mg, 1.4 mmol), 3-(pyrrolidin-3-ylmethyl)pyridine dioxalate (527 mg, 1.54 mmol), HOAt (28.6 mg, 0.21 mmol) and DIPEA (0.98 ml, 5.6 mmol) in CH2Cl2 (10 ml), and the mixture was stirred overnight at RT. After removal of the solvent in vacuo, the product was purified by column chromatography (silica, CH2Cl2/(7 M NH3 in methanol), 99/1-96/4). Yield: 378 mg, 52%
    • Example 206 Preparation of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(1H-pyrrolo[3,4-c]pyridin-2(3H)-yl)ethanone
  • Figure US20080153843A1-20080626-C00171
  • EDCI (486 mg, 2.53 mmol) was added to a solution of the acid (627 mg, 1.69 mmol), 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine hydrochloride (291 mg, 1.86 mmol), HOAt (34.5 mg, 0.25 mmol) and DIPEA (0.89 ml, 5.07 mmol) in CH2Cl2 (10 ml), and the mixture was stirred overnight at RT. After removal of the solvent in vacuo, the product was purified by column chromatography (silica, CH2Cl2/(7 M NH3 in methanol), 99/1-97/3). Yield: 481 mg, 60%
    • Example 207 Preparation of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(pyridin-3-yl)morpholino)ethanone
  • Figure US20080153843A1-20080626-C00172
  • EDCI (497 mg, 2.59 mmol) was added to a solution of the acid (642 mg, 1.73 mmol), 2-(pyridin-3-yl)morpholine oxalate (483 mg, 1.90 mmol), HOAt (35.3 mg, 0.26 mmol) and DIPEA (0.91 ml, 5.18 mmol) in CH2Cl2 (10 ml), and the mixture was stirred overnight at RT. After removal of the solvent in vacuo, the product was purified by column chromatography (silica, CH2Cl2/(7 M NH3 in methanol), 99/1-96/4). Yield: 453 mg, 51%
    • Example 205 Preparation of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(pyrazin-2-yloxy)benzyl)acetamide
  • Figure US20080153843A1-20080626-C00173
  • EDCI (580 mg, 3.02 mmol) was added to a solution of the acid (749 mg, 2.02 mmol), (2-(pyrazin-2-yloxy)phenyl)methanamine hydrochloride (527 mg, 2.22 mmol), HOAt (41.2 mg, 0.30 mmol) and DIPEA (1.06 ml, 6.05 mmol) in CH2Cl2 (10 ml), and the mixture was stirred overnight at RT. After removal of the solvent in vacuo, the product was purified by column chromatography (silica, CH2Cl2/(7 M NH3 in methanol), 99/1-97/3). Yield: 977 mg, 87%
    • Example 196 Preparation of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(pyrazin-2-yloxy)benzyl)acetamide Preparation of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl chloride
  • Figure US20080153843A1-20080626-C00174
  • Oxalyl chloride (3.68 ml, 42.8 mmol) and a catalytic amount of DMF were added to a solution of the acid (5.3 g, 14.3 mmol) in CH2Cl2 (100 ml), and the mixture was stirred overnight at RT. After removal of the solvent in vacuo, the residue was coevaporated with CH2Cl2 (3×50 ml). Yield: 5.38 g, 96%
    • Preparation of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(pyrazin-2-yloxy)benzyl)acetamide
  • Figure US20080153843A1-20080626-C00175
  • 4-(pyrazin-2-yloxy)-benzylamine hydrochloride (439 mg, 1.85 mmol) was added to a solution of the acid chloride (600 mg, 1.54 mmol) and Et3N (535 μl, 3.85 mmol) in CH2Cl2 (10 ml). The reaction mixture was stirred for 4 h at RT. The solvent was then removed in vacuo. The product was purified by column chromatography (silica, CH2Cl2/(7 M NH3 in methanol), 95/5). Yield: 468 mg, 55%
    • Example 195 Preparation of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(pyrazin-2-yloxy)benzyl)acetamide
  • Figure US20080153843A1-20080626-C00176
  • EDCI (387 mg, 2.0 mmol) was added at 0° C. to a solution of the acid (500 mg, 1.35 mmol), (3-(pyrazin-2-yloxy)phenyl)methanamine hydrochloride (320 mg, 1.35 mmol), HOAt (27.5 mg, 0.20 mmol) and DIPEA (705 μl, 4.1 mmol) in CH2Cl2 (10 ml), and the mixture was stirred for 30 min. at 0° C. and overnight at RT. After removal of the solvent in vacuo, the product was purified by column chromatography (silica, CH2Cl2/(7 M NH3 in methanol), 99/1-95/5). Yield: 412 mg, 55%
    • Example 193 Preparation of N-(4-(4,5-dihydro-1H-imidazol-2-yl)benzyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methylacetamide hydrochloride
  • Figure US20080153843A1-20080626-C00177
  • Methylamine (350 ml of a 40% aqueous solution, 4.06 mol) was added to a solution of 4-(bromomethyl)benzonitrile (51.3 g, 262 mmol) in EtOH (500 ml). After 2 h, the solvent was removed in vacuo and CH2Cl2 (500 ml) and aqueous saturated NaHCO3 solution (400 ml) were added. The organic phase was separated off and extracted with aqueous saturated NaCl solution (250 ml), over Na2SO4, and the solvent was removed after filtration in vacuo. The residue was taken up in 1 M HCl in Et2O (300 ml) and stirred for 30 min., then filtered off and washed with Et2O. The residue was taken up in H2O (500 ml), rendered basic with aqueous 6 M NaOH and extracted with CH2Cl2 (500 ml). The organic phase was dried over Na2SO4 and filtered off, and the solvent was removed in vacuo. Yield: 31.17 g, 81%
  • Figure US20080153843A1-20080626-C00178
  • Et3N (35.96 ml, 256 mmol) was added to a solution of the amine (31.17 g, 213 mmol) in CH2Cl2 (150 ml). Benzyl chloroformate (36.37 ml, 256 mmol) in CH2Cl2 (50 ml) was then added dropwise at a temperature of 0° C. The reaction mixture was stirred overnight at RT and washed with aqueous 0.1 M HCl (150 ml) and H2O (150 ml), dried over Na2SO4 and filtered out, and the solvent was removed in vacuo.
  • Figure US20080153843A1-20080626-C00179
  • Sulfur (3.41 g, 107 mmol) was added to a reaction mixture of the carbamate (62.1 g, max. 213 mmol) and ethylenediamine (192 ml, 2.87 mol), and stirring was carried out for 2 h at 100° C. After cooling to RT, H2O (250 ml) was added, and extraction with ethyl acetate (2×250 ml) was carried out. The combined organic phases were extracted with H2O (250 ml) and dried over Na2SO4, and the solvent was removed after filtration in vacuo. Yield: 67.6 g, 98%
  • Figure US20080153843A1-20080626-C00180
  • A solution of (Boc)2O (50.2 g, 230 mmol) in CH2Cl2 (500 ml) was added dropwise to a solution of the imidazoline (67.6 g, 209 mmol) and DMAP (28.1 g, 230 mmol) in CH2Cl2 (500 ml), and stirring was carried out overnight at RT. 0.5 M HCl (300 ml) and H2O (300 ml) were then added. The organic phase was separated off and dried over Na2SO4. After filtration, the solvent was removed in vacuo and product was purified by column chromatography (silica, CH2Cl2/MeOH, 98:2). Yield: 50.7 g, 57%
  • Figure US20080153843A1-20080626-C00181
  • The Boc-protected imidazoline (3.03 g, 7.15 mmol) was dissolved in absolute EtOH (60 ml) and hydrogenated under nitrogen for 10 min. with Pd/C (10%, 381 mg, 0.36 mmol) and hydrogen. After stirring for 2 h at RT, filtration over kieselguhr was carried out, followed by washing with EtOH. After removal of the solvent in vacuo, the product was used in the next step without being worked up further.
  • Figure US20080153843A1-20080626-C00182
  • A reaction mixture of the carboxylic acid (683 mg, 1.84 mmol), amine (2.10 g, 1.93 mmol), DIPEA (608 μl, 3.68 mmol) and HOAt (38 mg, 0.28 mmol) in CH2Cl2 (100 ml) was cooled to 0° C. EDCI (388 mg, 2.02 mmol) was then added, and stirring was carried out overnight at RT. After addition of aqueous saturated NaCl solution (25 ml), the aqueous phase was separated off and extracted with CH2Cl2 (25 ml). The combined organic phases were dried over Na2SO4 and, after filtration, the solvent was removed in vacuo. Purification was carried out by column chromatography (silica, CH2Cl2/MeOH, 95:5). Yield: 750 mg, 63%
  • Figure US20080153843A1-20080626-C00183
  • TFA (4.3 ml, 58 mmol) was added to a solution of the Boc-protected derivative (750 mg, 1.16 mmol) in CH2Cl2 (10 ml), and stirring was carried out for 4 h at RT. The solvent was removed in vacuo, and the residue was dissolved in CH2Cl2 (20 ml) and washed with aqueous saturated NaHCO3 solution (25 ml). The organic phase was separated off, dried over Na2SO4 and filtered off, and the solvent was removed in vacuo. The product was purified by column chromatography (silica, CH2Cl2/MeOH/Et3N, 95:5:2). The free amine was stirred for 1 h in 1 M HCl in Et2O (10 ml), and the solvent was removed in vacuo. The product was obtained in the form of the hydrochloride in a yield of 641 mg, 95%.
    • Pharmacological Studies Functional Study on the Bradykinin Receptor 1 (B1R)
  • The agonistic or antagonistic action of substances can be determined on the bradykinin receptor 1 (B1R) of the species human and rat using the following assay. According to this assay, the Ca2+ influx through the channel is quantified with the aid of a Ca2+-sensitive dye (type Fluo-4, Molecular Probes Europe BV, Leiden, Netherlands) using a Fluorescent Imaging Plate Reader (FLIPR, Molecular Devices, Sunnyvale, USA).
    • Method:
  • Chinese hamster ovary cells (CHO K1 cells) which have been stably transfected with the human B1R gene (hB1R cells, Euroscreen s.a., Gosselies, Belgium) or with the B1R gene of the rat (rB1R cells, Axxam, Milan, Italy) are used. For functional studies, the cells are plated out on black 96-well plates having a clear base (BD Biosciences, Heidelberg, Germany) in a density of 20,000-25,000 cells/well. The cells are incubated overnight at 37° C. and with 5% CO2 in culture medium (hB1R cells: Nutrient Mixture Ham's F12, Gibco Invitrogen GmbH, Karlsruhe, Germany; rB1R cells: D-MEM/F12, Gibco Invitrogen GmbH, Karlsruhe, Germany), with 10 vol. % FBS (fetal bovine serum, Gibco Invitrogen GmbH, Karlsruhe, Germany). On the following day, the cells are loaded for 60 minutes at 37° C. with 2.13 μM Fluo-4 (Molecular Probes Europe BV, Leiden, Netherlands) in HBSS buffer (Hank's buffered saline solution, Gibco Invitrogen GmbH, Karlsruhe, Germany) with 2.5 M probenecid (Sigma-Aldrich, Taufkirchen, Germany) and 10 mM HEPES (Sigma-Aldrich, Taufkirchen, Germany). The plates are then washed twice with HBSS buffer, and HBSS buffer additionally containing 0.1% BSA (bovine serum albumin; Sigma-Aldrich, Taufkirchen, Germany), 5.6 mM glucose and 0.05% gelatin (Merck KGaA, Darmstadt, Germany) is added to the plates. After incubation for a further 20 minutes at room temperature, the plates are inserted into the FLIPR for Ca2+ measurement. The Ca2+-dependent fluorescence is measured before and after the addition of substances (λex=488 nm, λem=540 nm). Quantification is carried out by measuring the highest fluorescence intensity (FC, fluorescence counts) over time.
    • FLIPR Assay:
  • The FLIPR protocol consists of 2 substance additions. Test substances (10 μM) are first pipetted onto the cells and the Ca2+ influx is compared with the control (hB1R: Lys-Des-Arg9-bradykinin 0.5 nM; rB1R: Des-Arg9-bradykinin 100 nM). This gives the activation in %, based on the Ca2+ signal after addition of Lys-Des-Arg9-bradykinin (0.5 nM) or Des-Arg9-bradykinin (100 nM).
  • After 10 minutes' incubation, 0.5 nM Lys-Des-Arg9-bradykinin (hB1R) or 100 nM Des-Arg9-bradykinin (rB1R) are applied, and the influx of Ca2+ is likewise determined. Antagonists lead to suppression of the Ca2+ influx. The % inhibition compared with the maximum achievable inhibition is calculated. The compounds exhibit good activity on the human and the rat receptor.
  • B1R Antagonism, B1R Antagonism, rat
    human [10 μM] [10 μM]
    Example % Inhibition % Inhibition
    1 104.68 106.8
    2 104.12 87.41
    3 103.84 108.97
    4 103.63 106.31
    5 102.96 102.66
    6 102.21 94.88
    7 101.85 99.28
    8 101.66 106.6
    9 101.53 85.33
    10 100 91.84
    11 99.62 105.97
    12 99.1 74.91
    13 97.67 112.52
    14 96.97 104.22
    15 96 92.47
    16 95.89 25.53
    17 95.53 96.94
    18 95.33 109.83
    19 95.03 98.89
    20 94.86 86.42
    21 93.47 107.92
    22 92.64 21.4
    23 92.35 85.35
    24 92.25 106.89
    25 91.03 80.59
    26 86.78 4.56
    27 85.41 97.69
    28 84.73 0
    29 84.37 109.8
    30 83.97 108.46
    31 83.75 94.69
    32 83.26 63.28
    33 82.71 47.69
    34 79.9 39.48
    35 79.7 99
    36 79.43 45.71
    37 78.23 102.66
    38 74.95 65.36
    39 73.21 0
    40 72.7 88.65
    41 72.61 16.38
    42 70.57 57.85
    43 69.88 24.16
    44 69.62 0
    45 69.07 92.41
    46 68.25 0
    47 68.07 48.84
    48 66.59 30.49
    49 65.88 92.34
    50 65.71 50.31
    51 65.06 87.91
    52 65.01 92.83
    53 64.83 0
    54 63.8 0
    55 63.23 88.78
    56 62.66 0
    57 62.39 0
    58 62.23 10.18
    59 61.48 0
    60 59.89 108.64
    61 59.7 30.54
    62 59.58 33.97
    63 58.57 26.41
    64 57.92 25.48
    65 55.41 93.17
    66 55.38 38.64
    67 55.03 80.49
    68 54.11 0
    69 53.64 82.89
    70 53.27 42.16
    71 53.19 95.22
    72 52.58 13.25
    73 51.02 105.54
    74 50.42 102.6
    75 50.14 9.11
    76 48.94 40.3
    77 47.95 104.71
    78 45.73 35.22
    79 45.47 54.49
    80 45.26 22.47
    81 44.9 34.14
    82 44.86 4.42
    83 43.94 30.77
    84 43.73 0
    85 43.69 40.84
    86 43.22 0
    87 42.69 44.38
    88 42.06 7.33
    89 41.34 0
    90 49.96 99.55
    91 48.78
    92 103.49 101.34
    93 105.57 99.12
    94 105.3 103.1
    95 106.86 100.63
    96 104.91 91.35
    97 98.05 98.2
    98 104.09 101.37
    99 103.76 100.08
    100 103.71 101.69
    101 100.27 100.47
    102 103.94 99.95
    103 105.15 100.39
    104 105.3 100.57
    105 105.66 100.37
    106 102.6 102.64
    107 102.05 102.39
    108 102.41 102.31
    109 102.82 101.69
    110 102.5 101.77
    111 91.86 101.4
    112 102.43 101.88
    113 99.23 97.07
    114 102.24 102.56
    115 102.47 58.09
    116 74.25 100.94
    117 100.65 100.53
    118 103.54 102.07
    119 95.94 61.85
    120 103.28 102.56
    121 70.47 52.72
    122 12.11 13.04
    123 43.88 79.94
    124 76.28 63.16
    125 50.56 95.36
    126 46.36 81.06
    127 102.31 93.69
    128 90.8 94.47
    129 0.03 31.23
    130 103.2 96.3
    131 82.09 95.37
    133 103.01 98.08
    134 102.44 98.25
    135 102.68 98.31
    136 103.97 98.94
    137 102.25 98.75
    138 103.55 98.45
    139 99.91 98.83
    140 100.08 80.7
    141 100.51 100.7
    142 89.91 62.99
    143 99.91 99.3
    144 100.57 98.16
    145 99.4 98.64
    146 97.26 99.64
    147 99.95 99.96
    148 100.09 99.97
    149 99.41 100.05
    150 98.31 99.06
    151 106.94 103.01
    152 100.06 90.83
    153 81.64 40.58
    154 83.21 84.36
    155 107.43 89.64
    156 108.3 102.71
    157 98.2 99.97
    158 98.49 99.3
    159 99.17 100.6
    160 98.97 99.04
    161 98.53 99.25
    162 99.53 99.51
    163 95.05 100.8
    164 99.63 100.63
    165 97.13 96.78
    166 99.44 99.28
    167 101.53 100.86
    168 93.83 98.38
    169 100.44 101.1
    170 101.02 97.85
    171 101.89 82.78
    172 101.45 85.19
    173 100.61 100.68
    174 101.35 97.95
    175 103.24 86.31
    176 −24.81 36.52
    177 103.86 100.43
    178 101.6 99.82
    179 104.26 100.13
    180 104 98.6
    181 105.03 98.54
    182 91.1 99.72
    183 100.16 96.92
    184 104.83 99
    185 105.43 97.93
    186 105.87 97.13
    187 100.41 101.8
    188 101.92 102.25
    189 70.72 86.37
    190 101.56 101.94
    191 — —
    192 105.69 100.29
    193 103.95 98.28
    194 103.08 100.27
    195 85.11 98.81
    196 100.47 98.8
    197 103.6 100
    198 105.4 99.75
    199 104.01 100.83
    200 102.44 98.73
    201 103.19 98.19
    202 103.84 99.79
    203 103.19 98.78
    204 104.58 98.98
    205 49.98 99.71
    206 53.94 99.49
    207 101.93 100.16
    208 104.84 100.76
    209 103.97 99.93
    210 106.17 96.03
    211 106.08 100.06
    212 106.74 100.18
    213 59.72 94.53
    214 101.16 101.91
    215 99.94 100.96
    216 −10.12 4.48
    217 — —
    218 100.43 —
    219 5.04 96.23
    220 15.27 86.34
    221 38.04 89.58
    222 7.55 113.93
    223 26.23 86.37
    224 72.06 52.77
    225 104.47 84.08
    226 76.38 96.87
    227 26.87 94.52
    228 88.56 99.82
    229 101.09 100.53
    230 95.42 62.33
    231 102.03 83.34
    232 102.37 90.03
    233 101.96 86.74
    234 51.96 103.02
    235 102.3 83.46
    236 95.86 99.58
    237 99.72 99.45
    238 99.93 99.35
    239 94.7 99.7
    240 78.48 97.3
    241 103.76 99.26
    242 102.04 87.99
    243 24.76 80.63
    244 70.16 97.28
    245 69.86 80.5
    246 56.38 72.1
    247 70.78 96.75
    248 95.6 89.86
    249 59.22 92.36
    250 96.85 90.55
    251 45.81 98.51
    252 101.72 97.94
    253 59.31 101.11
    254 105.08 97.8
    255 104.91 100.81
    256 50.23 91.02
    257 34.31 99.94
    258 75.25 99.75
    259 66.06 99.3
    260 101.6 60.62
    261 78.92 98.87
    262 81.81 99.65
    263 100.01 97.85
    264 103.07 31.71
    265 99.95 51.3
    266 102.46 2.12
    267 103.79 95.16
    268 103.88 101.64
    269 103.6 99
    270 103.77 93.42
    271 59.08 85.9
    272 97.14 84.61
    273 96.05 84.87
    274 103.75 98.08
    275 101.73 93.06
    276 98.92 94.16
    277 85.55 81.59
    278 103.71 96.94
    279 103.74 95.39
    280 103.9 92.04
    281 103.69 92.37
    282 102.79 85.95
    283 103.46 92.9
    284 102.93 93.55
    285 103.77 90.97
    286 103.72 97.93
    287 101.02 89.25
    288 101.83 93.34
    289 102.52 95.5
    290 104.09 92.91
    291 104.28 92.99
    292 105.83 99.22
    293 90.51 −6.96
    294 105.91 100
    295 96.67 103.18
    296 105.85 99.28
    297 105.76 102.53
    298 105.09 103.58
    299 106.32 102.79
    300 105.73 103.1
    301 106.36 100.99
    302 100.69 102.41
    303 106.27 100.4
    304 71.12 101.52
    305 76.41 95.47
    306 103.75 99.16
    307 105.47 98.38
    308 104.85 100.95
    309 52.02 101.11
    310 106.11 102.07
    311 94.88 103.15
    312 98.52 98.68
    313 103.46 102.58
    314 105.18 103.91
    315 105.13 100.59
    316 82.66 98.17
    317 92.19 100.22
    318 101.58 101.55
    319 104.47 100.08
    320 105.66 101.93
    321 41.19 100.13
    322 101.81 98.72
    323 104.72 88.06
    324 83.97 98.44
    325 101.91 100.88
    326 103.59 101.04
    327 104.27 100.52
    328 103.86 101.85
    329 104.89 98.16
    330 104.39 100.44
    331 105.94 100.52
    332 105.29 100.79
    333 107.07 100.76
    334 106.56 100.58
    335 106.11 99.82
    336 103.22 104.8
    337 103.65 104.4
    338 92.57 92.22
    339 77.54 41.63
    340 104.92 100.73
    341 104.72 102.33
    342 104.5 100.29
    343 79.97 100.23
    344 48.77 88.4
    345 22.26 95.94
    346 95.54 100.91
    347 56.56 102.91
    348 87.09 102.94
    349 100.78 102.8
    350 103.91 103.72
    351 44.01 103.99
    352 103.57 103.63
    353 102.72 102.17
    354 62.46 102.22
    355 83.39 101.52
    356 43.04 103.33
    357 79.38 104.35
    358 101.48 102.53
    359 98.56 102.84
    360 96.66 103.03
    361 93.42 100.74
    362 103.34 101.91
    363 90.7 101.09
    364 104.69 101.44
    365 55.61 99.85
    366 14.76 99.03
    367 20.1 102.67
    368 62.06 100.94
    369 82.34 100.93
    370 18.72 98.83
    371 0.38 100.72
    372 −2.76 83.81
    373 104.41 98.85
    374 80.78 101.66
    375 98.74 99.85
    376 67.07 99.02
    377 87.21 99.56
    378 63.42 98.75
    379 67.92 101.75
    380 91.51 100.9
    381 77.88 100.15
    382 103.44 101.03
    383 40.17 101.54
    384 104.56 98.56
    385 101.05 99.45
    386 100.74 97.86
    387 90.98 100.56
    388 22.88 100.66
    389 100.51 100.49
    390 102.87 99.78
    391 97.78 101.54
    392 100.93 99.09
    393 103.77 101.49
    394 31.48 99.08
    395 12.63 100.41
    396 24.69 80.61
    397 97.25 101.46
    398 59.84 98
    399 93.05 102.16
    400 62.01 102.17
    401 90.84 95.62
    402 47.09 101.25
    403 100.68 100.41
    404 55.06 98.55
    405 98.59 100.41
    406 102.96 100.21
    407 102.44 99.02
    408 102.22 99.79
    409 28.09 81.39
    410 102.43 102.85
    411 101.07 100.19
    412 101.44 102.89
    413 99.93 102.79
    414 100.97 100.12
    415 99.23 97.52
    416 50.22 100.96
    417 96.16 103.38
    418 101.28 103.53
    419 99.98 101.17
    420 100.33 92.05
    421 97.3 93.36
    422 48.04 98.61
    423 58.71 80.13
    424 35.11 97.61
    425 −0.97 98.84
    426 −4.95 94.38
    427 101.54 98.83
    428 23.84 101.75
    429 14.33 99.48
    430 38.56 100.57
    431 28.42 96.18
    432 94.03 100.3
    433 103.47 99.97
    434 103.69 101.47
    435 6.23 99.56
    436 39.2 101.6
    437 36.08 101.67
    438 22.12 99.98
    439 48.25 100.94
    440 98.07 95.62
    441 103.96 98.36
    442 101.8 98.56
    443 103.85 99.33
    444 92.79 98.58
    445 102.23 98.61
    446 95.03 99.75
    447 66.5 94.21
    448 85.75 99.78
    449 90.75 99.72
    450 87.36 99.66
    451 80.68 99.23
    452 104.82 95.19
    453 40.51 74.44
    454 101.91 100.32
    455 102.81 99.34
    456 100.44 100.76
    457 102 99.65
    458 102.65 100.43
    459 57.14 102.04
    460 96.59 100.78
    461 100.64 99.1
    462 101.3 98.25
    463 97.39 100.72
    464 56.56 101.94
    465 101.95 98.82
    466 92.52 99.72
    467 101.34 100.88
    468 84.49 101.4
    469 92.34 101.61
    470 92.67 98.07
    471 102.93 98.79
    472 92.06 101.17
    473 94.59 99.49
    474 96.7 96.3
    475 90.42 101.75
    476 90.06 100.14
    477 94.46 98.77
    478 36.16 90.24
    479 32.3 99.07
    480 100.76 102.62
    481 72.64 103.71
    482 97.92 102.46
    483 102.72 104.43
    484 75.57 100.57
    485 65.25 103.41
    486 70.44 101.22
    487 100.93 99.13
    488 100.99 101.64
    489 99.28 99.96
    490 93.52 103.22
    491 96.35 97.94
    492 102.54 103.95
    493 40.64 99.47
    494 26.16 73.41
    495 30.7 95.72
    496 68.19 103.02
    497 66.04 101.25
    498 94.25 96.7
    499 103.35 100.58
    500 41.81 93.22
    501 65.06 89.7
    502 96.74 103.44
    503 103.07 97.92
    504 24.18 90.61
    505 74.02 100.82
    506 98.27 98.91
    507 −10.08 102.4
    508 31.93 102.55
    509 92.72 102.13
    510 51.42 101.9
    511 86.96 102.91
    512 93.03 102.26
    513 73.53 101.16
    514 85.25 99.02
    515 30.9 100.15
    516 101.34 99.39
    517 98.85 101.92
    518 102.58 99.69
    519 81.88 102.71
    520 102.91 102.07
    521 85.17 99.34
    522 54.17 98.7
    523 66.38 101.41
    524 101.62 100.66
    525 15.41 102.31
    526 73.35 101.65
    527 97.16 97.33
    528 88.22 101.57
    529 105.85 101.47
    530 93.08 101.41
    531 92.59 96.17
    532 96.4 107.74
    533 105.76 107.71
    534 104.14 107.17
    535 48.36 107.33
    536 63.12 107.33
    537 12.53 98.72
    538 −11.76 105.77
    539 38.81 107.39
    540 7.17 100.18
    541 103.13 107.61
    542 49.24 107.2
    543 21.14 104.54
    544 11.72 106.99
    545 39.81 106.41
    546 7.44 104.05
    547 77.44 99.97
    548 24.68 95.44
    549 75.84 99.05
    550 57.78 101.12
    551 52.7 101.87
    552 46.78 101.41
    553 54.09 100.52
    554 25.2 101.97
    555 62.48 102.09
    556 12.13 85.58
    557 29.73 87.56
    558 −3.53 102.69
    559 99.91 100.17
    560 101.72 99.35
    561 102.13 101.17
    562 102.46 100.03
    563 101.86 100.42
    564 104.58 102.33
    565 104.82 102.52
    566 103.44 102.51
    567 104.25 102.19
    568 38.49 81.34
    569 90.04 92.89
    570 97.65 98.06
    571 103.97 100.34
    572 — 98.98
    573 — 101.21
    574 89.99 —
    575 23.44 96.83
    576 1.85 107.17
    577 17.34 107.05
    578 8.96 87.13
    579 39.4 107.07
    580 39.09 88.5
    581 27.54 76.31
    • Inhibition of the Bradykinin Receptor 1 (B1R)-Mediated Formation of IL-6 in Fibroblasts by Substances According to the Invention as B1R Antagonists
  • The pro-inflammatory cytokines TNFα (or IL-1) lead in various cell types, such as, for example, fibroblasts, to an activation, which brings about inter alia enhanced expression of B1R. Subsequent stimulation of these cells with a B1R agonist results in the formation of further pro-inflammatory cytokines, such as, for example, IL-6. The chronification of inflammations is thereby promoted. Treatment with a B1R antagonist should lead to inhibition of the B1R agonist-induced IL-6 formation. By way of example, a B1R antagonist identified in the FLIPR assay was tested in this respect.
    • Methods:
  • The human fibroblast cell line IMR-90 (ATCC, CCL-186) was passaged in culture medium (Ham's F12 nutrient mixture, Gibco Invitrogen GmbH, Karlsruhe Germany with 10% FBS, fetal bovine serum, Gibco, Invitrogen GmbH, Karlsruhe Germany; 0.1 mM non-essential amino acids, Gibco, 11140-035, 1 mM sodium pyruvate, Euro Clone, ECM0542D; 1.5 g/l sodium bicarbonate, Euro Clone, ECM0980D) on 80 cm2 bottles (Nunc; 178905) (ratio: 1:2 to 1:6; medium replaced every 3-4 days) and plated out for experiments on 96-well plates (Greiner bio-one; No. 655180) with 1×105 cells per well. The cells are incubated overnight at 37° C. and 5% CO2.
  • For activation with TNFα (human, recombinant, expressed in E. coli, SIGMA-ALDRICH T6674, 10 ng/ml) alone or TNFα combined with the human B1R agonist Lys-Des-Arg9-bradykinin (Lys-Des-Arg9-BK), the IMR-90 fibroblasts were incubated overnight at 37° C. and 5% CO2 in culture medium. The final concentrations of Lys-Des-Arg9-BK were 1000 nM or 10 nM. Some IMR-90 stimulation batches additionally contained the B1R antagonist of Example 8 in a final concentration of 10 μM. 24 hours after activation, in each case 150 μl of culture medium were removed from all the different stimulation batches and were transferred to a new plate and frozen. After thawing of the supernatants, the IL-6 content was determined by means of a commercially available IL-6 Elisa.
    • ELISA Assay (Procedure, Modified According the Manufacturer's Specifications):
  • Elisa kit: from: BIOSOURCE; CytoSets™, Art. No.: CHC 1264
    Material: 96-well microplates: NUNC Brand Systems, Art. No.: 442404A
    • Procedure:
  • Coating: application of primary antibody solution: 50 μl/well
    Incubation: covered plate overnight at RT, then tap the plate
    Blocking: application of blocking buffer: 300 μl/well; incubate plate for 2 hours at RT
    Washing: 3× with 300 μl of washing solution/well
    Standard; samples; secondary antibody: application standard, samples per 50 μl/well immediate addition of the secondary antibody solution: application: 25 μl/well
    Incubation: shake covered plate for 2 h at RT
    Washing: 3× with 300 μl of washing solution/well
    Streptavidin: application of streptavidin solution: 100 μl/well
    Incubation: covered plate 30 min. at RT
    Washing: 3× with 300 μl of washing solution/well
    Substrate: application of substrate solution: 100 μl/well
    Incubation: incubate plate for about 20 min. at RT in the dark, with shaking (dependent on the colour reaction)
    Termination: addition of 1.8 NH2SO4: 50 μl/well
    Measurement (within 30 min.):
    ELISA reader: from Mikrotek; MPP 4008
    Evaluation software: from Mikrotek; MikroWin 3.0
    Measuring filter: 450 nm
    Reference filter: 620 nm
  • The above-described processes were carried out with Example compound 8. The results are shown in the following table:
  • Production of IL-6 (pg/ml) by IMR-90 fibroblasts
    TNFα + Lys-Des- TNFα + Lys-Des-
    TNFα alone Arg9-BK (1000 nM) Arg9-BK (10 nM)
    without 149 pg/ml 2155 pg/ml 2462 pg/ml
    antagonist
    Example 8 136 pg/ml  483 pg/ml  119 pg/ml

    IMR-90 fibroblasts stimulated with TNFα or Lys-Des-Arg9-BK alone produce only small amounts of IL-6 (149 pg/ml and 34 pg/ml, respectively). Stimulation with TNFα in combination with Lys-Des-Arg9-BK results in an about 10- to 20-fold increase in IL-6 synthesis. This activation of IL-6 formation is inhibited by the B1R antagonist of Example 8 in a dose-dependent manner. The action of the relatively low dose of the agonist Lys-Des-Arg9-BK (10 nM) is eliminated almost completely, whereas a relatively high dose of Lys-Des-Arg9-BK (1000 nM) is still partially inhibited. The inhibitory action of Example 8 is B1R-specific, because the activating effect of TNFα alone is not taken into account.
    • Formalin Test in the Mouse
  • The formalin test (Dubuisson, D. and Dennis, S. G., 1977, Pain, 4, 161-174) represents a model for both acute and chronic pain. By means of a single formalin injection into the dorsal side of a rear paw, a biphasic nociceptive reaction is induced in freely mobile test animals; the reaction is detected by observing three behaviour patterns which are clearly distinguishable from one another. The reaction is two-phase: phase 1=immediate reaction (duration up to 10 min., shaking of the paw, licking), phase 2=late reaction (after a rest phase; likewise shaking of the paw, licking; duration up to 60 min.). The 1st phase reflects a direct stimulation of the peripheral nocisensors with high spinal nociceptive input (acute pain phase); the 2nd phase reflects a spinal and peripheral hypersensitization (chronic pain phase). In the studies described here, the chronic pain component (phase 2) has been evaluated.
  • Formalin in a volume of 20 μl and a concentration of 1% is administered subcutaneously into the dorsal side of the right rear paw of each animal. The specific changes in behavior, such as lifting, shaking or licking of the paw (score 3, Dubuisson & Dennis, 1977), are observed and recorded in the observation period of 21 to 24 minutes following the formalin injection. The behaviour of the animals after administration of the substance (n=10 per dose of substance) was compared with a control group which received vehicle (n=10).
  • Based on the quantification of the pain behavior, the action of the substance in the formalin test was determined as the change in percent compared with the control. The ED50 calculations (ED50=mean effective dose) were carried out by regression analysis according to the method of Litchfield and Wilcoxon (Litchfield, J. T., Wilcoxon, J. J., 1949, J. Pharmacol. Exp. Ther. 96, 99-113). The time of administration before the formalin injection was chosen in dependence on the mode of administration of the compounds according to the invention (intravenous: 5 min.).
  • The ED50 values of some examples are given in the following table:
  • Type of
    Example administration ED50 value [mg/kg]
    8 i.v. 12.8
    97 i.v. 13.3
    98 i.v. 13.6
    193 i.v. 2.59
    • Parenteral Solution of a Substituted Sulfonamide Derivative According to the Invention
  • 38 g of one of the substituted sulfonamide derivatives according to the invention, in this case Example 1, are dissolved in 1 litre of water for injection purposes at room temperature and then adjusted to isotonic conditions by addition of anhydrous glucose for injection purposes.
  • The foregoing description and examples have been set forth merely to illustrate the invention and are not intended to be limiting. Since modifications of the described embodiments incorporating the spirit and substance of the invention may occur to persons skilled in the art, the invention should be construed broadly to include all variations within the scope of the appended claim and equivalents thereof.

Claims (25)

1. A substituted sulfonamide compound corresponding to formula I
Figure US20080153843A1-20080626-C00184
wherein
m represents 1 or 2;
n represents 0, 1, 2 or 3;
R1 represents aryl or heteroaryl;
R2a-c, R3 and R4 represent H or, with an adjacent radical R2a-c, R3 or R4, form a five- or six-membered ring which can be saturated or unsaturated and mono- or poly-substituted and which can contain hetero atoms from the group N and O,
R5 and R6 together form a saturated or unsaturated, 4- to 8-membered, nonaromatic ring optionally fused to an aromatic, saturated or unsaturated 4- to 10-membered ring, and the 4- to 8-membered ring or the fused 4- to 10-membered ring or both is substituted by or fused to a basic radical and is optionally substituted by one or more further basic radicals selected from the group consisting of C1-6-alkyl, C1-3-alkoxy, C3-4-cycloalkyl, ═O, aralkyl and aryl; or
R5 and R6 together form a 4- to 8-membered ring containing a further hetero atom selected from the group consisting of N and O, said further hetero atom containing ring optionally being substituted by a basic or non-basic radical and, if the substituent radical is not bonded via the further hetero atom N to the 4- to 8-membered ring, then that further hetero atom N can additionally be substituted by a C1-6-alkyl group, an aryl or aralkyl group; or
R5 represents H, C1-6-alkyl, C3-8-cycloalkyl, aryl or aralkyl, and R6 represents aryl, C3-4-cycloalkyl, or aryl or C3-8-cycloalkyl linked via a C1-3-alkyl chain, the aryl or C3-8-cycloalkyl ring optionally being fused to a 5- to 10-membered saturated or unsaturated ring optionally containing one or more hetero atoms, and the aryl or C3-4-cycloalkyl ring or the bridging C1-3-alkyl chain being substituted by a basic radical; or
R5 represents H, C1-6-alkyl, C3-8-cycloalkyl, aryl or aralkyl, and R6 represents C4-4-heterocyclyl or C4-6-heterocyclyl linked via a C1-4-alkyl chain, the heterocyclyl ring optionally being substituted on one or two ring members by a basic or non-basic radical; or
R5 and R6, independently of one another, represent H, aralkyl or a branched or unbranched, optionally mono- or poly-substituted C1-10-alkyl radical which contains from one to three nitrogen atoms, with the proviso that R5 and R6 do not both represent H; or
R5 represents H, C1-6-alkyl, C3-8-cycloalkyl, aralkyl or aryl, and R6 represents an optionally mono- or poly-substituted basic heteroaryl radical optionally linked via a C1-4-alkyl group optionally substituted by a basic radical;
wherein, unless otherwise indicated. the C1-6-alkyl, C1-3-alkoxy, aralkyl, aryl and heteroaryl radicals can be unsubstituted or mono- or poly-substituted, and the C3-8-cycloalkyl radical can be unsubstituted or monosubstituted on one or more ring members;
in the form of a pure stereoisomer or a mixture of stereoisomers in any mixing ratio;
or a salt thereof with a physiologically acceptable acid.
2. A compound according to claim 1, wherein the compound is in the form of a pure enantiomer or diastereoisomer.
3. A compound according to claim 1, wherein the compound is in the form of a racemic mixture.
4. A compound according to claim 1, wherein
m represents 1 or 2;
n represents 0, 1, 2 or 3;
R1 represents aryl or heteroaryl, unsubstituted or mono- or poly-substituted;
R2a-c, R3 and R4 represent H or form with an adjacent radical R2a-c, R3 or R4 a saturated or unsaturated five- or six-membered ring optionally mono- or poly-substituted and optionally containing one or more hetero atoms selected from the group consisting of N and O;
R5 and R6 together form a 4- to 8-membered ring which can be saturated or unsaturated but not aromatic, wherein the 4- to 8-membered ring can be fused to an aromatic, saturated or unsaturated 4- to 10-membered ring, and the 4- to 8-membered ring and/or the fused 4- to 10-membered ring is substituted by or fused to a basic radical and can be substituted by a further basic radical or radicals from the group C1-6-alkyl, C1-3-alkoxy, C3-8-cycloalkyl, ═O, aralkyl and aryl; or
R5 and R6 together form a 4- to 8-membered ring which contains a further hetero atom from the group N and O and can be substituted by a basic or non-basic radical and, in the case where the basic or non-basic substituent is not bonded via the further hetero atom N to the 4- to 8-membered ring, that further hetero atom N can additionally be substituted by a C1-6-alkyl group, an aryl or aralkyl group; or
R5 represents H, C1-6-alkyl, C3-8-cycloalkyl, aryl or aralkyl, and R6 represents aryl, C3-4-cycloalkyl or aryl or C3-4-cycloalkyl linked via a C1-3-alkyl chain, the aryl or C3-8-cycloalkyl ring optionally being fused to a saturated or unsaturated 5- to 10-membered ring optionally containing one or more hetero atoms, and the aryl or C3-4-cycloalkyl ring or bridging C1-3-alkyl chain optionally being substituted by a basic radical; or
R5 represents H, C1-6-alkyl, C3-8-cycloalkyl, aryl or aralkyl, and R6 represents C4-4-heterocyclyl or C4-8-heterocyclyl linked via a C1-4-alkyl chain, wherein the heterocyclyl ring can be substituted on one or two ring members by a basic or non-basic radical; or
R5 and R6, independently of one another, represent H, aralkyl or a branched or unbranched, optionally mono- or poly-substituted C1-10-alkyl radical which contains from one to three nitrogen atoms, with the proviso that R5 and R6 do not both represent H; or
R5 represents H, C1-6-alkyl, C3-8-cycloalkyl, aralkyl or aryl, and R6 represents an optionally mono- or poly-substituted basic heteroaryl radical optionally linked via a C1-4-alkyl group optionally substituted by a basic radical;
wherein, unless otherwise indicated, the C1-6-alkyl, C1-3-alkoxy, aralkyl, aryl and heteroaryl can be unsubstituted or mono- or poly-substituted and the radical C3-4-cycloalkyl can be unsubstituted or monosubstituted on one or more ring members;
in the form of a pure stereoisomer or a mixture of stereoisomers in any mixing ratio;
or a salt thereof with a physiologically acceptable acid;
wherein
a substituted aryl or heteroaryl radical is mono- or poly-substituted by F, Cl, Br, I, CN, NH2, NH—C1-6-alkyl, NH—C1-6-alkyl-OH, N(C1-6-alkyl)2, N(C1-6-alkyl-OH)2, NHaryl; N(aryl)2, N(C1-6-alkyl)aryl, NO2, SH, S—C1-6-alkyl, OH, O—C1-6-alkyl, O—C1-6-alkyl-OH, C(═O)C1-6-alkyl, CO2H, CH2SO2-phenyl, CO2—C1-6-alkyl, OCF3, CF3,
Figure US20080153843A1-20080626-C00185
 C1-6-alkyl, pyrrolidinyl, imidazolyl, piperidinyl, morpholinyl, benzyloxy, phenoxy, phenyl, pyridyl, alkylaryl, especially benzyl, thienyl or furyl;
a substituted cycloalkyl radical or alkyl radical is substituted by F, Cl, Br, I, —CN, NH2, NH—C1-6-alkyl, NH—C1-6-alkyl-OH, C1-6-alkyl, N(C1-6-alkyl)2, N(C1-6-alkyl-OH)2, NO2, SH, S—C1-6-alkyl, S-benzyl, O—C1-6-alkyl, OH, O—C1-6-alkyl-OH, ═O, O-benzyl, C(═O)C1-6-alkyl, CO2H, CO2—C1-6-alkyl or benzyl;
a basic radical represents an optionally fused heterocycle containing at least one nitrogen atom as hetero atom, wherein the heterocycle can optionally be monosubstituted on one or more ring members by C1-6-alkyl, F, Cl, Br, I, —CN, NH2, NH(C1-6-alkyl), N(C1-6-alkyl)2, —NH(aryl), —N(C1-3-alkyl)(aryl), wherein those aryl radicals can be mono- or poly-substituted by F, Cl, Br, CF3, CN, OH or OMe, O—C1-6-alkyl, heterocyclyl or OH;
N(C1-6-alkyl)2, NHC1-6-alkyl, a N(C1-6-alkyl)-2-substituted aryl radical, an aryl or heteroaryl radical substituted by a 5- to 7-membered heterocyclyl containing at least one N hetero atom;
wherein all the above-mentioned basic radicals can be linked to the structure of the general formula I via a bridging —O—, —NH—, —NH[(—CH2)p—]— group, —N(C1-3-alkyl)[—(CH2)p—]— group, —O—[(CH2)p—]— group, —O—[—(CH2)p—O—]— group, wherein in each case p=1, 2 or 3, or C1-3-alkyl group, and wherein the bridging-(CH2)p— groups or the C1-3-alkyl chain are optionally substituted by ═O, F, Cl, Br, I, —CN, phenyl or pyridinyl and the remaining radicals can themselves be substituted by C1-6-alkyl;
C1-6-alkylN(C1-6-alkyl)2 or C1-6-alkylNH(C1-6-alkyl), and
if the basic radical is fused to the heterocycle formed from R5 and R6, represents a 6-membered, saturated, unsaturated or aromatic heterocycle containing at least one N hetero atom, then a non-basic radical represents —CN, C1-6-alkyl, optionally substituted by methoxy or C1-3-alkoxy; or aryl, heteroaryl, a 3- to 7-membered heterocycle containing at least one oxygen or sulfur atom (pyran, thiophene), each unsubstituted or mono- or poly-substituted, or unsubstituted C3-8-cycloalkyl or C3-8-cycloalkyl monosubstituted on one or more ring members, which can be linked to the structure of the general formula I via a —O—, —O—[(CH2)q—]— or —[(CH2)q—]—O— group, —O—[—(CH2)q—O—]— group or a bridging C1-3-alkyl group, wherein the —(CH2)q— chain or the alkyl chain can each be substituted by ═O and q=1, 2 or 3; and wherein the substituents on the aryl, heteroaryl, 3- to 7-membered heterocycle and C3-4-cycloalkyl are selected from F, Cl, Br, I, CN, NO2, aralkyl, SH, S—C1-6-alkyl, OH, O—C1-6-alkyl, O—C1-6-alkyl-OH, C(═O)C1-6-alkyl, CO2H, CH2SO2-phenyl, CO2—C1-6-alkyl, OCF3, CF3,
Figure US20080153843A1-20080626-C00186
 C1-6-alkyl,
in connection with R6C4-8-heterocyclyl represents a saturated or unsaturated, 4- to 8-membered cyclic radical which can contain 1, 2, 3, 4 or 5 identical or different hetero atoms in the ring system, wherein the hetero atoms are preferably selected from the group N, O and S and wherein both the bond of the heterocyclyl radical to the general basic structure of formula I and the optional substitution with the basic or non-basic groups can be present on any desired ring member;
in connection with R6 a basic heteroaryl radical represents a 5- to 10-membered, fused or non-fused hetero-atom-containing radical which contains at least one nitrogen atom as hetero atom and wherein both the bond of the heteroaryl radical to the general basic structure of formula I, or the bond of the heteroaryl radical to the bridging C1-4-alkyl group, and the optional substitution can be present on any desired ring member of the heteroaryl radical (range of preferences: pyrrolyl, pyrazolyl, imidazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, indolyl, indazolyl, benzoimidazolyl and quinolinyl, quinoxalinyl, quinazolinyl),
in connection with R6 a 5- to 10-membered, aromatic or unsaturated ring fused to an aryl group and optionally containing one or more hetero atoms is selected from the group:
Figure US20080153843A1-20080626-C00187
wherein R7 represents H or C1-6-alkyl,
in connection with R6 a 5- to 10-membered, saturated or unsaturated ring fused to a C3-4-cycloalkyl ring and optionally containing one or more hetero atoms is selected from the group consisting of phenyl, pyridinyl, cyclopentane, cyclohexane and cycloheptane, and
an aromatic, unsaturated or saturated 4- to 10-membered ring fused to the 4- to 8-membered ring formed by R5 and R6 is a ring selected from the group consisting of C4-10-cycloalkane, C4-10-cycloalkene and C6-10-aromatic compounds and 6-membered heteroaromatic compounds.
5. A compound according to claim 1, wherein R1 represents unsubstituted or mono- or poly-substituted phenyl, naphthyl, indolyl, benzofuranyl, benzothiophenyl, benzooxazolyl, benzooxadiazolyl, pyrrolyl, furanyl, thiophenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, imidazothiazolyl, carbazolyl, dibenzofuranyl or dibenzothiophenyl.
6. A compound according to claim 5, wherein R1 represents phenyl, naphthyl, benzo-thiophenyl, benzooxadiazolyl, thiophenyl, pyridinyl, imidazothiazolyl and dibenzofuranyl which may be unsubstituted or mono- or poly-substituted by C1-3-alkoxy, C1-6-alkyl, Br, Cl, F, I, CF3, OCF3, OH, SH, or unsubstituted or mono- or poly-substituted aryl or heteroaryl.
7. A compound according to claim 1, wherein R1 represents phenyl or naphthyl, optionally mono- or poly-substituted with one or more substituents selected from the group consisting of methyl, methoxy, —CF3, Cl, Br and F.
8. A compound according to claim 1, wherein R2a-c, R3 and R4 each represent H or form with an adjacent radical R2a-c, R3 or R4 an optionally mono- or poly-substituted aromatic ring,
9. A compound according to claim 8, wherein one of R2a-c, R3 and R4 forms with an adjacent radical R2a-c, R3 or R4 a benzene group optionally mono- or poly-substituted by at least one substituent selected from the group consisting of methyl, methoxy, CF3—, Cl, Br and F.
10. A compound according to claim 1, wherein m is 1, and n is 1 or 2.
11. A compound according to claim 1, wherein
a) the group NR5R6 forms a cyclic group corresponding to formula a1, a2 or a3
Figure US20080153843A1-20080626-C00188
wherein
k=0, 1, 2 or 3,
w, x, y and z, independently of one another, represent CH or N, with the provisos that not more than two of w, x, y and z simultaneously represent N and that, in the cyclic group according to formula a4, at least one group from w, x, y and z represents N, and
B represents a basic radical selected from the group consisting of:
—NR8R9, wherein R8 and R9, independently of one another, represent H or C1-6-alkyl, and
a radical corresponding to formula aa1
Figure US20080153843A1-20080626-C00189
wherein
aa1, a, b and c, independently of one another, can be 0 or 1, with the proviso that when b is equal to 0, a and c are not simultaneously 1;
the bridging C1-3-alkyl can be monosubstituted by ═O; and
R10 represents a 4- to 10-membered, aromatic, unsaturated or saturated, mono- or poly-cyclic heterocyclyl group which can contain 1, 2, 3 or 4 N hetero atoms and optionally O or S as further hetero atoms, wherein the heterocyclyl group is unsubstituted or monosubstituted on one or more ring members; or
R10 represents an aryl group substituted by at least one —NR11R12 group or a 5- or 6-membered, monocyclic N-containing aromatic, saturated or unsaturated heterocycle containing 1 or 2 N hetero atoms, wherein R11 and R12, independently of one another, represent H or C1-6-alkyl, and the aryl group can optionally carry further substituents; or
R10 represents a group corresponding to formula aa2:
Figure US20080153843A1-20080626-C00190
wherein
 d is 1, 2 or 3;
 R13 can be H or C1-3-alkyl;
 R14, for each chain member d independently, can be H or an optionally substituted aryl or N-heteroaryl group, preferably phenyl, naphthyl or pyridinyl, wherein R14 can be H only once within the alkyl chain defined by d, and
 R15 is a 5- to 7-membered, saturated or unsaturated heterocyclyl group which is optionally monosubstituted on one or more ring members, contains 1 or 2 N hetero atoms and can contain O or S as further hetero atoms; or
b) the group NR5R6 is a cyclic group corresponding to formula b1 or b2:
Figure US20080153843A1-20080626-C00191
wherein
k=1 or 2,
l=1, 2 or 3,
Z is NR17 or O, where R17 is H or C1-6-alkyl, and
R16 represents H or a group of the general formula bb1:
Figure US20080153843A1-20080626-C00192
wherein
a and c, independently of one another, are 0 or 1,
b=0, 1, 2 or 3, with the proviso that when b=0, a and c are not simultaneously 1, and wherein in the alkyl chain defined by b, a CH2 chain member can be replaced by C(═O),
R18 is selected from the group consisting of
unsubstituted or mono- or poly-substituted aryl or heteroaryl, wherein the heteroaryl contains 1, 2 or 3 N hetero atoms and can contain O and S as further hetero atoms;
saturated or unsaturated 5- to 7-membered heterocyclyl, wherein the heterocyclyl contains at least one hetero atom selected from the group N, O and S, preferably 1 or 2 N hetero atoms, and can optionally be monosubstituted or monosubstituted on a plurality of ring members;
C1-6-alkyl, optionally mono- or poly-substituted;
C3-8-cycloalkyl, optionally monosubstituted or monosubstituted on a plurality of ring members; and
excluding compounds in which i) c=1 or ii) b=c=0 and a=1, R18 can also be selected from the group consisting of —CN and NR19R20, where R19 and R20 are independently selected from the group consisting of H and C1-6-alkyl, with the proviso that R19 and R20 are not simultaneously H; or
c) in the group NR5R6:
R5 is selected from the group consisting of H and C1-6-alkyl, optionally mono- or poly-substituted, and
R6 is a group corresponding to formula c1 or c2
Figure US20080153843A1-20080626-C00193
wherein
a=0, 1 or 2;
b=0, 1, 2 or 3;
R21 is an unsubstituted or substituted aryl group,
R22 and R23, independently of one another, represent —H or C1-6-alkyl, or
NR22R23 as a group represents a 5-, 6- or 7-membered, saturated or unsaturated heterocycle which contains at least one N hetero atom and can optionally be monosubstituted or monosubstituted on a plurality of ring members;
Figure US20080153843A1-20080626-C00194
wherein
a=0, 1, 2 or 3;
b=0 or 1, with the proviso that when b=0 also c=0;
c=0, 1, 2 or 3,
Y represents aryl or heteroaryl (preferably N-containing), optionally substituted; C3-8-cycloalkyl, preferably C5-6-cycloalkyl; and
Z represents a saturated, unsaturated or aromatic, optionally substituted heterocyclyl group which contains at least one N hetero atom and can contain O and/or S as further hetero atoms; or Z represents a group NR24R25, wherein R24 and R25, independently of one another, represent H, C1-6-alkyl or —C(═O)—(CH2)d—NR26R27, wherein d=1 or 2, and R26 and R27, independently of one another, represent H or C1-6-alkyl, or NR26R27 forms a 5-, 6- or 7-membered, preferably saturated heterocycle; or
d) in the group NR5R6:
R5 is selected from the group consisting of H, C1-6-alkyl, optionally mono- or poly-substituted, C3-8-cycloalkyl, optionally monosubstituted on one or more ring members, and
R6 is selected from groups of the general formula d1
Figure US20080153843A1-20080626-C00195
wherein
a=0, 1, 2, 3 or 4;
b=0 or 1, with the proviso that when b=0 also c=0;
c=0, 1, 2 or 3;
J represents a 4- to 7-membered heterocycle which contains at least one N-hetero atom and is preferably saturated or unsaturated and which can optionally be monosubstituted on one or more ring members, and
K represents H or an optionally substituted aryl or heteroaryl group; or
e) in the group NR5R6:
R5 and R6 are independently selected from the group consisting of H; C1-6-alkyl; aralkyl; and —(CH2), NR28R29, wherein r=from 1 to 6, and wherein R28 and R29 are independently selected from the group consisting of H and C1-3-alkyl; or
f) in the group NR5R6:
R5 is selected from the group consisting of H, C1-6-alkyl, aryl and aralkyl, and
R6 is a group of the —(C1-4-alkyl)n-X type, wherein s=0 or 1 and wherein X is a heteroaryl group which contains at least one N hetero atom and is optionally mono- or poly-substituted, and wherein in the C1-4-alkyl group a hydrogen atom can be replaced by a 5- or 6-membered heterocyclyl group which contains at least one N hetero atom and can contain, in addition to N, also O and/or S as hetero atom.
12. A compound according to claim 10, wherein
a) NR5R6 forms a cyclic group selected from the group consisting of
Figure US20080153843A1-20080626-C00196
wherein
B is a basic radical selected from the group consisting of
—N(C1-6-alkyl)n, where n=1 or 2;
a radical corresponding to formula (aa1), wherein
R10 is a heterocyclic group selected from the group consisting of:
Figure US20080153843A1-20080626-C00197
wherein the heterocyclic group can be unsubstituted or monosubstituted on one or more ring members by C1-6-alkyl, F, Cl or Br; or
R10 represents
Figure US20080153843A1-20080626-C00198
which can be unsubstituted or mono- or poly-substituted by C1-6-alkyl, F, Cl, Br, C1-6-alkoxy, or phenyl; or
R10 represents phenyl substituted by —N(C1-3-alkyl)2, pyrrolidinyl, imidazolidinyl, dihydroimidazolyl, wherein the linking can take place at any of the ring members of the phenyl and of the substituent; or
R10 represents a group corresponding to formula (aa2), wherein
d is 1 or 2,
R13 represents H or methyl,
R14 represents phenyl or pyridinyl, and
R15 represents morpholinyl or 4-methylpiperazinyl; or
b) NR5R6 forms a heterocycle selected from the group consisting of
Figure US20080153843A1-20080626-C00199
wherein
R16 represents a group corresponding to formula bb1 wherein
(i) a=0, b=1, 2 or 3 and c=0, or
(ii) a=0, b=1, 2 or 3 and c=0; and
R18 is a cyclic substituent selected from the group consisting of
Figure US20080153843A1-20080626-C00200
wherein the cyclic substituent can be unsubstituted or mono- or poly-substituted by C1-3-alkyl, C1-3-alkoxy, F, Cl, Br, I; —CN; CF3; N(C1-3-alkyl)2, NH(C1-3-alkyl), N(C1-3-alkyl)(aryl), N(C1-3-alkyl)(alkylaryl), wherein the aryl or alkylaryl substituent can be mono- or poly-substituted; benzyl; or
Figure US20080153843A1-20080626-C00201
wherein all those substituents can likewise be mono- or poly-substituted by F, Cl, Br, —CN, —CF3, C1-3-alkyl; pyrrolidinyl, piperidinyl, 4-methylpiperidinyl or morpholinyl; or
R18 represents a heterocyclyl group selected from the group consisting of:
Figure US20080153843A1-20080626-C00202
wherein the heterocyclyl group can be monosubstituted on one or more ring members; or
R18 represents cyclopentyl, cyclohexyl, optionally monosubstituted on one or more ring members, or C1-3-alkyl, optionally mono- or poly-substituted; or
c) in the group NR5R6:
R5 is selected from the group consisting of H and methyl, ethyl, propyl and isopropyl, optionally mono- or poly-substituted, and
R6 represents a group according to the general formula c1, wherein
R21 is a phenyl or naphthyl group which can be unsubstituted or mono- or poly-substituted by F, Cl, Br, I, CN, C1-3-alkyl;
R22 and R23, independently of one another, represent methyl, ethyl or propyl or isopropyl, or
NR22R23 as a group represents an N heterocycle selected from the group consisting of:
Figure US20080153843A1-20080626-C00203
wherein the N heterocycle can be unsubstituted or monosubstituted on one or more ring members, or
R6 represents a group of the general formula c2, wherein
Y represents phenyl, naphthyl, benzooxadiazole, cyclopentyl, cyclohexyl or cycloheptyl, all optionally monosubstituted on one or more ring members, and
Z is selected from the group consisting of N(C1-3-alkyl)2;
Figure US20080153843A1-20080626-C00204
wherein those radicals can be monosubstituted on one or more ring members, and R30, R31 and R40 can represent H, methyl, ethyl, propyl or isopropyl, optionally mono- or poly-substituted, or
Z is selected from the group consisting of:
Figure US20080153843A1-20080626-C00205
wherein R32, R33 and R34 are selected from H, methyl, ethyl, propyl and isopropyl, optionally mono- or poly-substituted, and the N heterocycles can optionally be monosubstituted on one or more ring members; or
Z is a group NR24R25, wherein R24 and R25, independently of one another, represent methyl, ethyl, propyl or isopropyl; or
Z represents a group —C(═O)—(CH2)d—NR26R27, wherein d is 1 or 2 and NR26R27 together form a heterocycle selected from the group consisting of
Figure US20080153843A1-20080626-C00206
wherein the ring members of those radicals can be monosubstituted on one or more ring members, and R35 and R36 can represent methyl, ethyl, propyl or isopropyl, optionally mono- or poly-substituted; or
d) in the group NR5R6:
R5 is selected from the group consisting of H and methyl, ethyl, propyl and isopropyl, optionally mono- or poly-substituted, and
R6 represents a group of the general formula d1, wherein
J is selected from the group consisting of:
Figure US20080153843A1-20080626-C00207
K is selected from the group consisting of H, phenyl, naphthyl, pyridinyl, all optionally mono- or poly-substituted; or
e) in the group NR5R6:
R5 is selected from the group consisting of H, C1-3-alkyl, —(CH2)r—NR28R29, wherein r=from 1 to 3 and wherein R28 and R29 can be C1-3-alkyl, and
R6 represents —(CH2)r—NR28R29, wherein r=from 1 to 3 and wherein R28 and R29 can be C1-3-alkyl, or
R6 represents a C1-3-alkyl group substituted by a N(C1-3-alkyl)(aryl) group, wherein the aryl group is optionally substituted; or
f) in the group NR5R6:
R5 represents H, methyl, ethyl, propyl, isopropyl, phenyl or benzyl, and
R6 represents a group corresponding to the formula (C1-3-alkyl)-X, wherein s=0 or 1, wherein the C1-3-alkyl group can be substituted by a pyrrolidinyl, piperidinyl, piperazinyl or morpholinyl group, and X is selected from the group consisting of:
Figure US20080153843A1-20080626-C00208
wherein R41, R42 and R43 are selected from H, methyl, ethyl, propyl and isopropyl, optionally mono- or poly-substituted, and the N-heteroaryls can optionally be mono- or poly-substituted.
13. A compound according to claim 11, wherein
a) NR5R6 forms a cyclic group corresponding to the formula
Figure US20080153843A1-20080626-C00209
wherein B represents
a basic radical of the formula (aa1); wherein i) a=b=c=0, ii) a=c=0 and b=1, iii) a=b=0 and c=1 or iv) a=b=1 and c=0; or
a basic radical of the formula (aa2) wherein d=1 or 2, R14 is pyridinyl, and R15 is morpholinyl; or
b) NR5R6 forms a cyclic group corresponding to the formula
Figure US20080153843A1-20080626-C00210
wherein R16 represents a group of the formula bb1 wherein a=c=0 and b=0, 1 or 2 and R18 is selected from
Figure US20080153843A1-20080626-C00211
wherein the phenyl group is optionally substituted by F, Cl or Br; or
c) in NR5R6
R5 is selected from the group consisting of H, methyl, ethyl, propyl and isopropyl, preferably methyl, and
R6 represents a group according to the general formula c2 wherein a=1 or 2, b=1 and c=0, Y represents phenyl or cyclohexyl and Z represents pyrrolidinyl or dihydroimidazolyl.
14. A compound according to claim 13, wherein B represents a basic radical of formula aa2 wherein d=2 and R14 is 3-pyridinyl.
15. A compound according to claim 13, wherein the phenyl group is monosubstituted by F in the 4-position.
16. A compound according to claim 1, wherein:
m represents 1 or 2;
n represents 0, 1, 2 or 3;
R1 represents aryl or heteroaryl, unsubstituted or mono- or poly-substituted;
R2a-c, R3 and R4 represent H or, with an adjacent radical R2a-c, R3 or R4, form a five- or six-membered ring which can be saturated or unsaturated and mono- or poly-substituted and which can contain hetero atoms from the group N and O,
R5 and R6 together form a 4- to 8-membered ring which can be saturated or unsaturated but not aromatic, is substituted by or fused to a basic radical and can be substituted by a further basic radical or radicals from the group C1-6-alkyl, C1-3-alkoxy, C3-4-cycloalkyl and optionally substituted phenyl; or
R5 and R6 together form a 4- to 8-membered ring which contains a further hetero atom from the group N and O and can be substituted by a basic or non-basic radical, or
R5 represents H or C1-5-alkyl and R6 represents aryl or C3-4-cycloalkyl; or an aryl radical linked via a C1-3-alkyl chain, wherein the aryl or C3-8-cycloalkyl ring is substituted by a basic radical or, where appropriate, the basic substitution takes place on the bridging C1-3-alkyl chain, or
R5 represents H or C1-5-alkyl and R6 represents C4-8-heterocyclyl; or a C4-8-heterocyclyl radical linked via a C1-3-alkyl chain, wherein the heterocyclyl ring is substituted by a basic radical or a non-basic radical, or
R5 and R6, independently of one another, represent H or a branched or unbranched C1-10-alkyl radical containing from one to three nitrogen atoms, wherein R5 and R6 do not both represent H,
in the form of a pure stereoisomer or a mixture of stereoisomers in any mixing ratio or a salt thereof with a physiologically acceptable acid.
17. A compound according to claim 16, wherein
R5 and R6 together form a 4- to 8-membered ring which can be saturated or unsaturated but not aromatic and can be substituted by a basic radical, or
R5 and R6 together form a 4- to 8-membered ring which contains at least one further hetero atom from the group N and O and can be substituted by a basic radical or a non-basic radical from the group aryl, heteroaryl, each unsubstituted or mono- or poly-substituted by F, Cl, Br, I, CF3, OCH3, C1-6-alkyl, C3-8-cycloalkyl, unsubstituted or mono- or poly-substituted by F, Cl, Br, I, CF3, OCH3, C1-6-alkyl; which can be linked to the structure of the general formula I via a C1-3-alkyl chain, wherein the alkyl chain can be substituted by ═O; C1-6-alkyl or C1-3-alkoxy; or
R5 represents H and R6 represents aryl or C3-4-cycloalkyl; and R6 represents an aryl radical linked via a C1-3-alkyl chain, wherein the aryl or C3-8-cycloalkyl ring is in each case substituted by at least one basic radical, or
R5 represents H or C1-5-alkyl and R5 represents C4-8-heterocyclyl, wherein the heterocyclyl radical is linked to the structure of the general formula I via a carbon atom; or R6 represents a C4-8-heterocyclyl radical linked via a C1-3-alkyl chain, wherein the heterocyclyl ring is substituted by a basic radical or a non-basic radical from the group aryl, heteroaryl, each unsubstituted or mono- or poly-substituted by F, Cl, Br, I, CF3, OCH3, C1-6-alkyl, C3-4-cycloalkyl, unsubstituted or mono- or poly-substituted by F, Cl, Br, I, CF3, OCH3, C1-6-alkyl; which can be linked to the structure of the general formula I via a C1-3-alkyl chain, wherein the alkyl chain can be substituted by ═O; C1-6-alkyl or C1-3-alkoxy;
wherein in all cases the basic radical is selected from the group
Figure US20080153843A1-20080626-C00212
wherein
k represents 0, 1 or 2,
L represents H or C1-6-alkyl,
K represents C1-6-alkyl,
M represents C1-6-alkyl or N(CH3)2, and
J represents 2-, 3- or 4-pyridyl, phenyl, piperidyl or C1-6-alkyl.
18. A compound according to claim 1, wherein the group
Figure US20080153843A1-20080626-C00213
19. A compound according to claim 1, wherein said compound is selected from the group consisting of:
1 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-N-(4-piperidin-1-ylmethyl-benzyl)-acetamide
2 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-N-(4-piperidin-1-ylmethyl-benzyl)-acetamide
3 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-N-[4-(4-methyl-piperazin-1-yl)-benzyl]-acetamide
4 N-(4-piperidin-1-ylmethyl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
5 1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-ethanone
6 1-(4-benzyl-[1,4]diazepan-1-yl)-2-[1-(naphthyl-1-sulfonyl)-piperidin-2-ylmethoxy]-ethanone
7 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-N-[4-(4-methyl-piperazin-1-ylmethyl)-benzyl]-acetamide
8 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-ethanone
9 1-(1,4′-bipiperidin-1-yl)-2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl)methoxy)ethanone
10 N-(4-piperidin-1-ylmethyl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-acetamide
11 N-(4-dimethylaminomethyl-benzyl)-2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
12 N-(1-benzyl-piperidin-3-ylmethyl)-2-[1-(2,4,6-trimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
13 N-[4-(4-methyl-piperazin-1-yl)-benzyl]-2-[1-(2,4,6-trichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
14 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-N-(4-piperidin-1-yl-benzyl)-acetamide
15 N-[4-(4-methyl-piperazin-1-ylmethyl)-benzyl]-2-[1-(2,4,6-trichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
16 N-(1-benzyl-piperidin-3-ylmethyl)-2-[1-(3,4-dichloro-phenylsulfonyl)-2,3-dihydro-1H-indol-2-ylmethoxy]-acetamide
17 2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-pyrrolidin-1-yl)piperidin-1-yl)ethanone
18 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-N-[4-(4-methyl-piperazin-1-yl)-benzyl]-acetamide
19 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyrrolidin-1-yl)piperidin-1-yl)-ethanone
20 2-((1-(3,4-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)-ethyl)piperidin-1-yl)ethanone
21 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-N-(4-morpholin-4-yl-benzyl)-acetamide
22 1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-[1-(3-trifluoromethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
23 2-((1-(naphthalen-1-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyrrolidin-1-yl)piperidin-1-yl)ethanone
24 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-N-(4-morpholin-4-ylmethyl-benzyl)-acetamide
25 1-[4-(3-dimethylamino-propyl)-piperazin-1-yl]-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-ethanone
26 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-(4-pyrrolidin-1-yl-piperidin-1-yl)-ethanone
27 1-(2-piperidin-1-ylmethyl-pyrrolidin-1-yl)-2-[1-(2,4,6-trimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
28 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-ethanone
29 N-[4-(4-methyl-piperazin-1-yl)-benzyl]-2-[1-(2,4,6-trichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-acetamide
30 N-(4-morpholin-4-ylmethyl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
31 1-(4-benzyl-[1,4]diazepan-1-yl)-2-[1-(2,4,6-trimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
32 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-ethanone
33 N-[3-(4-methyl-piperazin-1-yl)-benzyl]-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-acetamide
34 N-(1-benzyl-piperidin-3-ylmethyl)-2-[1-(naphthyl-1-sulfonyl)-piperidin-2-ylmethoxy]-acetamide
35 N-(4-dimethylaminomethyl-benzyl)-2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-acetamide
36 2-((1-(3,4-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)-ethyl)piperidin-1-yl)ethanone
37 N-(4-dimethylaminomethyl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
38 2-((2-(3,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(pyrrolidin-1-yl)piperidin-1-yl)ethanone
39 1-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
40 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-N-[4-(4-methyl-piperazin-1-ylmethyl)-benzyl]-acetamide
41 N-(1-benzyl-piperidin-3-ylmethyl)-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-acetamide
42 2-((1-(3,4-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)-ethyl)piperazin-1-yl)ethanone
43 2-[2-(3,4-dichloro-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-N,N-bis-(2-diethylamino-ethyl)-acetamide
44 1-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-2-[1-(3,4-dichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-ethanone
45 N-[4-(4-methyl-piperazin-1-ylmethyl)-benzyl]-2-[1-(2,4,6-trichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-acetamide
46 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(2-methoxy-ethyl)-piperazin-1-yl]-ethanone
47 N-methyl-N-(2-morpholin-4-yl-1-phenyl-ethyl)-2-[1-(naphthyl-1-sulfonyl)-piperidin-2-ylmethoxy]-acetamide
48 N,N-bis-(2-diethylamino-ethyl)-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetra-hydro-isoquinolin-3-ylmethoxy]-acetamide
49 N-(4-morpholin-4-ylmethyl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-acetamide
50 N-(3-morpholin-4-yl-benzyl)-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-acetamide
51 2-[2-(2,4-dichloro-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-1-(2-piperidin-1-ylmethyl-pyrrolidin-1-yl)-ethanone
52 2-((1-(4-methoxyphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)-ethyl)piperidin-1-yl)ethanone
53 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(3-methoxy-phenyl)-piperazin-1-yl]-ethanone
54 1-(4-cyclohexylmethyl-piperazin-1-yl)-2-[1-(3,4-dichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-ethanone
55 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-N-(4-morpholin-4-ylmethyl-benzyl)-acetamide
56 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-(4-phenyl-piperazin-1-yl)-ethanone
57 1-(4-benzyl-piperidin-1-yl)-2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
58 1-[4-(3-dimethylamino-propyl)-piperazin-1-yl]-2-[1-(3-trifluoromethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
59 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone
60 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-N-(4-piperidin-1-yl-benzyl)-acetamide
61 N-(4-morpholin-4-ylmethyl-benzyl)-2-[1-(naphthyl-1-sulfonyl)-piperidin-2-ylmethoxy]-acetamide
62 2-[1-(3,4-dichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-ethanone
63 1-[2-(4-dimethylamino-phenyl)-azepan-1-yl]-2-[1-(naphthyl-1-sulfonyl)-piperidin-2-ylmethoxy]-ethanone
64 2-[1-(naphthyl-1-sulfonyl)-piperidin-2-ylmethoxy]-1-(2-piperidin-1-ylmethyl-pyrrolidin-1-yl)-ethanone
65 2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-morpholinopiperidin-1-yl)ethanone
66 1-(3-dimethylamino-pyrrolidin-1-yl)-2-[1-(naphthyl-1-sulfonyl)-piperidin-2-yl-methoxy]-ethanone
67 1-(4-benzyl-[1,4]diazepan-1-yl)-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-ethanone
68 1-(4-cyclohexylmethyl-piperazin-1-yl)-2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
69 2-((2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(2-piperidin-1-yl)ethyl)piperidin-1-yl)ethanone
70 N-(1-benzyl-piperidin-3-ylmethyl)-2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-yl-methoxy]-acetamide
71 N-(4-piperidin-1-yl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-pyrrolidin-2-yl-methoxy]-acetamide
72 2-((1-(3,4-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)-ethyl)piperazin-1-yl)ethanone
73 N-(4-dimethylaminomethyl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-acetamide
74 N-(4-piperidin-1-yl-benzyl)-2-[1-(2,4,6-trichloro-phenylsulfonyl)-piperidin-2-yl-methoxy]-acetamide
75 N-[2-(4-methyl-piperazin-1-yl)-benzyl]-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-acetamide
76 N-(3-piperidin-1-ylmethyl-phenyl)-2-[1-(2,4,6-trimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
77 1-[4-(3-methoxy-phenyl)-piperazin-1-yl]-2-[1-(2,4,6-trimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone
78 N-(1-benzyl-pyrrolidin-3-yl)-2-[2-(2,4-dichloro-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-N-methyl-acetamide
79 1-(4-benzyl-[1,4]diazepan-1-yl)-2-[2-(2,4-dichloro-phenylsulfonyl)-1,2,3,4-tetra-hydro-isoquinolin-3-ylmethoxy]-ethanone
80 N-[2-(4-methyl-piperazin-1-yl)-benzyl]-2-[1-(2,4,6-trimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
81 2-[1-(3,4-dichloro-phenylsulfonyl)-2,3-dihydro-1H-indol-2-ylmethoxy]-N-(4-pyrrolidin-1-ylmethyl-benzyl)-acetamide
82 2-[2-(3,4-dichloro-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-1-(2-piperidin-1-ylmethyl-pyrrolidin-1-yl)-ethanone
83 N-(4-pyrrolidin-1-ylmethyl-benzyl)-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-acetamide
84 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(4-methoxy-phenyl)-piperazin-1-yl]-ethanone
85 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(3-dimethylamino-propyl)-piperazin-1-yl]-ethanone
86 2-[1-(3,4-dichloro-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(2-fluoro-phenyl)-piperazin-1-yl]-ethanone
87 N-[4-(2-methyl-imidazol-1-yl)-phenyl]-2-[1-(2,4,6-trimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-acetamide
88 2-[1-(3,4-dichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-1-[4-(3-dimethylamino-propyl)-piperazin-1-yl]-ethanone
89 2-[1-(3,4-dichloro-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-1-(4-phenyl-piperazin-1-yl)-ethanone
90 2-(2-(1-(4-methoxyphenylsulfonyl)piperidin-2-yl)ethoxy)-1-(4-(2-(piperidin-1-yl)-ethyl)piperidin-1-yl)ethanone
91 2-(2-(1-(4-methoxyphenylsulfonyl)piperidin-2-yl)ethoxy)-1-(4-phenethylpiperazin-1-yl)ethanone
92 3-((4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)-piperazin-1-yl)methyl)benzonitrile hydrochloride
93 3-((4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetyl)-piperazin-1-yl)methyl)benzonitrile hydrochloride
94 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone hydrochloride
95 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
96 1-(3,4-dihydro-2,6-naphthyridin-2(1H)-yl)-2-((1-(4-methoxy-2,6-dimethylphenyl-sulfonyl)piperidin-2-yl)methoxy)ethanone hydrochloride
97 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
98 1-(4-(dihydro-1H-pyrido[1,2-a]pyrazin-2(6H,7H,8H,9H,9aH)-yl)piperidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
99 1-(4-dihydro-1H-pyrido[1,2-a]pyrazin-2(6H,7H,8H,9H,9aH)-yl)piperidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone dihydrochloride
100 1-(4-(3,4-dihydro-2,6-naphthyridin-2(1H)-yl)piperidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
101 tert-butyl 4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperazin-1-carboxylate
102 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(piperazin-1-yl)ethanone hydrochloride
103 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)ethanone
104 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(tetrahydro-2H-pyran-4-yl)piperazin-1-yl)ethanone
105 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylcyclohexyl)piperazin-1-yl)ethanone
106 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone dihydrochloride
107 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
108 2-((1-(2,6-dichloro-4-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
109 2-((1-(2-chloro-6-methylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
110 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(naphthalen-1-ylsulfonyl)piperidin-2-yl)methoxy)ethanone
111 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(naphthalen-2-ylsulfonyl)piperidin-2-yl)methoxy)ethanone
112 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone hydrochloride
113 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(thieno[3,2-d]pyrimidin-4-yl)piperazin-1-yl)ethanone
114 2-((1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
115 2-((1-(4-chloro-3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
116 1-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperidin-4-one
117 1-(4-((1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
118 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
119 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(2,4,6-triisopropylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
120 2-((1-(2,4-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
121 2-((1-(3-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
122 2-((1-(3-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
123 2-((1-(4-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
124 2-((1-(3-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
125 2-((1-(4-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
126 2-((1-(4-bromophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
127 (S)-2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
128 2-((1-(5-chloro-1,3-dimethyl-1H-pyrazol-4-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
129 2-((1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
130 1-(4-fluoro-1,4′-bipiperidin-1′-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
131 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(3-(o-tolyloxy)phenylsulfonyl)piperidin-2-yl)methoxy)ethanone
133 (S)-2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
134 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-(trifluoromethyl)cyclohexyl)piperazin-1-yl)ethanone
135 (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)azetidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
136 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-morpholin-2-(pyridin-3-yl)ethylamino)piperidin-1-yl)ethanone
137 2-((1-(benzo[b]thiophen-3-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
138 2-((1-(2-chloro-4-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
139 2-((1-(2-chlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
140 (R)-2-((1-(4-methoxy-2,3,6-trimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
141 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
142 (S)-2-((2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
143 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(1-(pyridin-4-yl)piperidin-4-yl)ethyl)acetamide
144 1-(4-(5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)piperidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
145 1-(4-(5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)piperidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
146 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-carbonyl)piperidin-1-yl)ethanone
147 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
148 2-((1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
149 2-((1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
150 2-((1-(4-bromo-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
151 2-((1-(5-chloro-3-methylbenzo[b]thiophen-2-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
152 (R)-2-((1-(2-chloro-6-methylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
153 2-((1-(2,5-bis(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
154 2-((1-(7-chlorobenzo[c][1,2,5]oxadiazol-4-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
155 2-((1-(4-methylnaphthalen-1-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
156 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(2,4,5-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone dihydrochloride
157 2-((1-(2-methylnaphthalen-1-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
158 2-((1-(5-(dimethylamino)naphthalen-1-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
159 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(o-tolylsulfonyl)piperidin-2-yl)methoxy)ethanone dihydrochloride
160 2-((1-(4-bromo-2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
161 (S)-2-((1-(2-chloro-6-methylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone hydrochloride
162 (S)-2-((1-(2-chloro-6-methylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
163 (S)-2-((1-(2-chloro-6-methylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone dihydrochloride
164 2-(2-(1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)ethoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
165 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-3-yloxy)piperidin-1-yl)ethanone
166 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(quinoxalin-6-ylmethyl)piperazin-1-yl)ethanone
167 (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
168 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-(pyrrolidin-1-yl)quinazolin-7-yl)piperazin-1-yl)ethanone
169 2-((1-(4-fluoro-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
170 2-((1-(2,5-dichlorothiophen-3-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
171 2-((1-(benzo[b]thiophen-2-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
172 2-((1-(2,5-dimethylthiophen-3-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
173 2-((1-(2,3-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
174 2-((1-(4-methoxynaphthalen-1-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
175 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(quinolin-8-ylsulfonyl)piperidin-2-yl)methoxy)ethanone dihydrochloride
176 2-((1-(isoquinolin-5-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
177 (R)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
178 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((2-(naphthalen-2-ylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)ethanone dihydrochloride
179 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonyl)piperidin-2-yl)methoxy)ethanone dihydrochloride
180 (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
181 (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone
182 (S)-2-((2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
183 (S)-2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
184 (S)-2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone
185 (S)-2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone
186 (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yloxy)piperidin-1-yl)ethanone hydrochloride
187 (S)-2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone
188 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-((pyridin-4-yloxy)methyl)piperidin-1-yl)ethanone
189 (S)-2-((2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone dihydrochloride
190 (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethanone hydrochloride
191 2-((1-(2-chloronaphthalen-1-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone dihydrochloride
192 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
193 N-(4-(4,5-dihydro-1H-imidazol-2-yl)benzyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methylacetamide hydrochloride
194 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methyl-N-(2-(4-(pyrrolidin-1-yl)cyclohexyl)ethyl)acetamide
195 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(pyrazin-2-yloxy)benzyl)acetamide
196 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(pyrazin-2-yloxy)benzyl)acetamide
197 1-(4-((5-chloro-2-phenyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
198 1-(4-((1,5-dimethyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
199 1-(4-((2-(dimethylamino)pyrimidin-5-yl)methyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
200 1-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)piperidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
201 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperidin-1-yl)ethanone
202 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
203 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(naphthalen-2-ylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)ethanone
204 2-((1-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
205 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(pyrazin-2-yloxy)benzyl)acetamide
206 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(1H-pyrrol[3,4-c]pyridin-2(3H)-yl)ethanone
207 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(pyridin-3-yl)morpholin)ethanone
208 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(3-(pyridin-3-ylmethyl)pyrrolidin-1-yl)ethanone
209 N-(2-(4-(dimethylamino)cyclohexyl)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methylacetamide
210 2-((1-(6-methoxynaphthalen-2-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
211 1-(4-(3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)piperidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
212 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(1-methylpiperidin-4-yl)ethyl)piperazin-1-yl)ethanone
213 2-((1-(3,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)-N-(2-(4-(dimethylamino)cyclohexyl)ethyl)-N-methylacetamide
214 1-(4-((2-((4-fluorophenyl)(methyl)amino)pyrimidin-5-yl)methyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
215 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(6-(4-methylpiperazin-1-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone
216 2-((1-(3,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methoxy)-N-methyl-N-(2-(4-(pyrrolidin-1-yl)cyclohexyl)ethyl)acetamide
217 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-3-yl)piperidin-1-yl)ethanone
218 N—((S)-1-benzylpyrrolidin-3-yl)-N-methyl-2-((1-(2-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)acetamide
219 2-((1-(4-methoxyphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3-methylbenzyl)piperazin-1-yl)ethanone
220 2-((1-(4-methoxyphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-phenethylthiazol-2-yl)piperazin-1-yl)ethanone
221 2-(2-(1-(4-methoxyphenylsulfonyl)piperidin-2-yl)ethoxy)-1-(4-(2-(piperidin-1-yl)ethyl)piperazin-1-yl)ethanone
222 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(5-methyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethanone
223 1-(2-((4,6-dimethylpyridin-2-yl)methyl)piperidin-1-yl)-2-((2-(mesitylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)ethanone
224 1-(2-(5-bromopyridin-3-yl)piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)ethanone
225 1-(1,4′-bipiperidin-1′-yl)-2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)ethanone
226 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(pyridin-2-ylmethyl)pyrrolidin-1-yl)ethanone
227 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(6-methoxypyridin-3-yl)piperidin-1-yl)ethanone
228 1-(2-((5-ethylpyridin-2-yl)methyl)piperidin-1-yl)-2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)ethanone
229 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(2-((3-methylpyridin-2-yl)methyl)piperidin-1-yl)ethanone
230 1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)-2-((1-(naphthen-1-ylsulfonyl)piperidin-2-yl)methoxy)ethanone
231 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
232 2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone
233 2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
234 1-(4-(4-benzylthiazol-2-yl)piperazin-1-yl)-2-((1-(mesitylsulfonyl)piperidin-2-yl)methoxy)ethanone
235 1-(1,4′-bipiperidin-1′-yl)-2-((1-(naphthen-1-ylsulfonyl)piperidin-2-yl)methoxy)ethanone
236 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(3-(pyridin-2-yl)pyrrolidin-1-yl)ethanone
237 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(3-(pyridin-3-yl)pyrrolidin-1-yl)ethanone
238 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(3-(pyridin-4-yl)pyrrolidin-1-yl)ethanone
239 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methyl-N-(2-(pyridin-4-yl)ethyl)acetamide
240 1-(2-((4,6-dimethylpyridin-2-yl)methyl)pyrrolidin-1-yl)-2-((1-(naphthen-1-ylsulfonyl)piperidin-2-yl)methoxy)ethanone
241 2-((1-(4-methoxy-2,6-dimethylphenysulfonyl)piperidin-2-yl)methoxy)-N-methyl-N-(1-phenyl-2-(pyrrolidin-1-yl)ethyl)acetamide
242 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-methylpiperazin-1-yl)ethanone
243 N-(2-(1H-indol-3-yl)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
244 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-methylquinolin-4-yl)acetamide
245 1-(4-(2-ethoxyethyl)piperazin-1-yl)-2-((2-(mesitylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)ethanone
246 2-((2-(mesitylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(2-methoxyethyl)piperazin-1-yl)ethanone
247 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(pyridin-2-yl)pyrrolidin-1-yl)ethanone
248 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(4-methylpiperazin-1-yl)ethyl)acetamide
249 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-morpholin-2-(4-(trifluoromethyl)phenyl)ethyl)acetamide
250 N-(5-(dimethylamino)pentyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
251 N-(2-(2-chlorophenyl)-2-morpholinoethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
252 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(4-methoxyphenyl)-2-(pyrrolidin-1-yl)ethyl)acetamide
253 1-(4-(3,5-dimethoxyphenyl)piperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
254 1-(4-(2-(diisopropylamino)ethyl)piperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
255 N-(1-benzylpiperidin-4-yl)-N-cyclopropyl-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
256 N-(2-morpholino-2-(pyridin-3-yl)ethyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
257 N-(1-ethyl-1H-pyrazol-5-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
258 N-(isoquinolin-5-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
259 N-(2-(dimethylamino)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
260 N-(3-(2,6-dimethylpiperidin-1-yl)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
261 N-(2-(dimethylamino)-1-phenylethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
262 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(1-phenyl-2-(pyrrolidin-1-yl)ethyl)acetamide
263 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(4-methylpiperazin-1-yl)-1-phenylethyl)acetamide
264 N-(3-morpholinophenyl)-2-((2-(phenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)acetamide
265 2-((2-(2,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-N-(3-morpholinophenyl)acetamide
266 2-((1-(3,4-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(piperidin-1-ylmethyl)morpholino)ethanone
267 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
268 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)ethyl)piperidin-1-yl)ethanone
269 1-(4-(2-(2,5-dimethyl-1H-pyrrol-1-yl)ethyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
270 1-(4-(2-(diisopropylamino)ethyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
271 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(2-(pyridin-2-yl)pyrrolidin-1-yl)ethanone
272 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(3-(pyridin-3-yl)pyrrolidin-1-yl)ethanone
273 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(3-(pyridin-4-yl)pyrrolidin-1-yl)ethanone
274 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
275 2-((2-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
276 2-((2-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(2-(piperidin-1-yl)ethyl)piperidin-1-yl)ethanone
277 2-((2-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(2-((6-methylpyridin-2-yl)methyl)piperidin-1-yl)ethanone
278 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
279 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)ethyl)piperidin-1-yl)ethanone
280 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(2,5-dimethyl-1H-pyrrol-1-yl)ethyl)piperazin-1-yl)ethanone
281 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(diisopropylamino)ethyl)piperazin-1-yl)ethanone
282 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(3-(pyridin-4-yl)pyrrolidin-1-yl)ethanone
283 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-4-yl)piperazin-1-yl)ethanone
284 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-((6-methylpyridin-2-yl)methyl)piperidin-1-yl)ethanone
285 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
286 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)ethyl)piperidin-1-yl)ethanone
287 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(2,5-dimethyl-1H-pyrrol-1-yl)ethyl)piperazin-1-yl)ethanone
288 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3-methoxyphenyl)piperazin-1-yl)ethanone
289 1-(4-(4-fluorophenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
290 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methoxyphenyl)piperazin-1-yl)ethanone
291 1-(4-isopropylpiperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
292 2-((2-(mesitylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
293 2-((1-(3,4-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(pyrrolidin-1-ylmethyl)phenyl)acetamide
294 N-(4-(dimethylamino)butyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
295 1-(4-ethylpiperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
296 1-(4-(pyrrolidin-1-yl)piperidin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
297 1-(4-morpholinopiperidin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
298 1-(1,4′-bipiperidin-1′-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
299 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-(pyrrolidin-1-ylmethyl)benzyl)acetamide
300 N-((1-benzylpiperidin-3-yl)methyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
301 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-(4-methylpiperazin-1-yl)phenyl)acetamide
302 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-(4-methylpiperazin-1-yl)benzyl)acetamide
303 N—((S)-1-benzylpyrrolidin-3-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-methylacetamide
304 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-methyl-N-(2-morpholino-1-phenylethyl)acetamide
305 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(pyridin-2-yl)piperazin-1-yl)ethanone
306 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(3-methoxyphenyl)piperazin-1-yl)ethanone
307 1-(4-(4-fluorophenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
308 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(4-methoxyphenyl)piperazin-1-yl)ethanone
309 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(pyrimidin-2-yl)piperazin-1-yl)ethanone
310 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-phenethylpiperazin-1-yl)ethanone
311 1-(4-(5-chloro-2-methylphenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
312 2-(4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetyl)piperazin-1-yl)nicotinonitrile
313 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(pyrrolidin-1-ylmethyl)benzyl)acetamide
314 N-((1-benzylpiperidin-3-yl)methyl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
315 N—((S)-1-benzylpyrrolidin-3-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-methylacetamide
316 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-2-yl)piperazin-1-yl)ethanone
317 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3-methoxyphenyl)piperazin-1-yl)ethanone
318 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-fluorophenyl)piperazin-1-yl)ethanone
319 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methoxyphenyl)piperazin-1-yl)ethanone
320 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenethylpiperazin-1-yl)ethanone
321 1-(4-(5-chloro-2-methylphenyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
322 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-(pyrrolidin-1-ylmethyl)benzyl)acetamide
323 N-((1-benzylpiperidin-3-yl)methyl)-2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
324 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(3-methoxyphenyl)piperazin-1-yl)ethanone
325 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(4-methoxyphenyl)piperazin-1-yl)ethanone
326 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-phenethylpiperazin-1-yl)ethanone
327 N-((1-benzylpiperidin-3-yl)methyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
328 1-(4-(4-methoxyphenyl)piperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
329 1-(4-phenethylpiperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
330 1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
331 1-(4-(2-(piperidin-1-yl)ethyl)piperidin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
332 1-(4-(2-(2,5-dimethyl-1H-pyrrol-1-yl)ethyl)piperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
333 1-(4-(2-(diisopropylamino)ethyl)piperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
334 N-(1-benzylpiperidin-4-yl)-N-cyclopropyl-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
335 1-(4-(pyridin-4-yl)piperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
336 1-(1,4′-bipiperidin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
337 1-(1,4′-bipiperidin-1′-yl)-2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
338 N-(2-(piperidin-1-yl)ethyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
339 N-(2-(pyrrolidin-1-yl)ethyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
340 1-(4-(3,5-dimethoxyphenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
341 1-(4-(2-(diisopropylamino)ethyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
342 N-(1-benzylpiperidin-4-yl)-N-cyclopropyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
343 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(pyrrolidin-1-yl)ethyl)acetamide
344 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-morpholinopropyl)acetamide
345 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(pyridin-3-ylmethyl)acetamide
346 1-(4-(3-chlorophenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
347 1-(4-(3,4-dimethylphenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
348 1-(4-(3,4-dichlorophenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
349 1-(4-(3,4-dichlorobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
350 1-(4-(4-bromobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
351 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2,4,6-trimethylbenzyl)piperazin-1-yl)ethanone
352 1-(4-(4-chlorobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
353 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(4-methylbenzyl)piperazin-1-yl)ethanone
354 1-(4-(3-chlorophenyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
355 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(3,4-dimethylphenyl)piperazin-1-yl)ethanone
356 1-(4-(3,4-dichlorophenyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
357 1-(4-(3,4-dichlorobenzyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
358 1-(4-(4-bromobenzyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
359 1-(4-(4-chlorobenzyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
360 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(4-methylbenzyl)piperazin-1-yl)ethanone
361 N-benzyl-N-(2-(dimethylamino)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
362 1-(4-benzyl-1,4-diazepan-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
363 1-((R)-3-(dimethylamino)pyrrolidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
364 N—((S)-1-benzylpyrrolidin-3-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methylacetamide
365 N-(1-benzylpyrrolidin-3-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
366 N-(3-(1H-imidazol-1-yl)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
367 N-(4-(dimethylamino)benzyl)-N-isopropyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
368 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methyl-N-(2-morpholino-1-phenylethyl)acetamide
369 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyridin-2-yl)piperazin-1-yl)ethanone
370 N-(isoquinolin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
371 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(1-methyl-1H-benzo[d]imidazol-2-yl)acetamide
372 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(pyrimidin-4-yl)acetamide
373 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenethylpiperazin-1-yl)ethanone
374 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-((S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)ethanone
375 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-methyl-1,4-diazepan-1-yl)ethanone
376 1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
377 N-benzyl-N-(2-(dimethylamino)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
378 1-(4-(3,4-dichlorophenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
379 N-(2-(dimethylamino)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methylacetamide
380 N-(2-(diethylamino)ethyl)-N-ethyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
381 1-(4-(3,4-dichlorobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
382 1-(4-(4-bromobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
383 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2,4,6-trimethylbenzyl)piperazin-1-yl)ethanone
384 1-(4-(4-chlorobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
385 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylbenzyl)piperazin-1-yl)ethanone
386 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methoxybenzyl)piperazin-1-yl)ethanone
387 1-(4-(2-fluorobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
388 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-methyl-2-phenylpiperazin-1-yl)ethanone
389 1-(3-(pyridin-3-yl)pyrrolidin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
390 1-(3-(pyridin-4-yl)pyrrolidin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
391 N-methyl-N-(2-(pyridin-4-yl)ethyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
392 N-methyl-N-(1-phenyl-2-(pyrrolidin-1-yl)ethyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
393 1-(4-methylpiperazin-1-yl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
394 N-(pyridin-4-ylmethyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
395 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-morpholinopyridin-3-yl)acetamide
396 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(6-morpholinopyridin-3-yl)acetamide
397 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(5-methyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethanone
398 1-(2-(4-(dimethylamino)phenyl)pyrrolidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
399 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(piperidin-1-ylmethyl)pyrrolidin-1-yl)ethanone
400 1-(2-(4-(dimethylamino)phenyl)azepan-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
401 N-(2-(4-benzylpiperazin-1-yl)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
402 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-phenylthiazol-2-yl)piperazin-1-yl)ethanone
403 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3,4-dimethylphenyl)piperazin-1-yl)ethanone
404 1-(4-(3,4-dichlorophenyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
405 1-(4-(3,4-dichlorobenzyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
406 1-(4-(4-bromobenzyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
407 1-(4-(4-chlorobenzyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
408 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylbenzyl)piperazin-1-yl)ethanone
409 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(pyrrolidin-1-yl)phenyl)acetamide
410 3-(4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperazin-1-yl)propanenitrile
411 N-(3-(4-benzylpiperazin-1-yl)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
412 N-(3-(4-ethylpiperazin-1-yl)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
413 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(piperidin-1-yl)propyl)acetamide
414 N-((1-benzylpyrrolidin-3-yl)methyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
415 N-((1-benzylpiperidin-3-yl)methyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
416 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(5-methyl-1H-pyrazol-1-yl)ethyl)acetamide
417 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(2-(l—methyl-1H-benzo[d]imidazol-2-yl)ethyl)phenyl)acetamide
418 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(piperidin-1-ylmethyl)phenyl)acetamide
419 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(piperidin-1-ylmethyl)phenyl)acetamide
420 N-(4-((1H-imidazol-1-yl)methyl)phenyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
421 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-((4-methylpiperidin-1-yl)methyl)phenyl)acetamide
422 N-((1-benzylpiperidin-3-yl)methyl)-2-((1-(4-methoxyphenylsulfonyl)indolin-2-yl)methoxy)acetamide
423 2-((1-(4-methoxyphenylsulfonyl)indolin-2-yl)methoxy)-N-(3-(piperidin-1-ylmethyl)phenyl)acetamide
424 N-(3-(ethyl(phenyl)amino)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
425 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(pyrazin-2-yl)ethyl)acetamide
426 N-(1-(1H-pyrazol-1-yl)propan-2-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
427 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(2-methyl-1H-imidazol-1-yl)phenyl)acetamide
428 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(piperidin-1-yl)benzyl)acetamide
429 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(piperidin-1-yl)phenyl)acetamide
430 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(piperidin-1-yl)benzyl)acetamide
431 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(4-methylpiperazin-1-yl)phenyl)acetamide
432 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(4-methylpiperazin-1-yl)benzyl)acetamide
433 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(4-methylpiperazin-1-yl)benzyl)acetamide
434 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(4-methylpiperazin-1-yl)benzyl)acetamide
435 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-morpholinobenzyl)acetamide
436 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-morpholinophenyl)acetamide
437 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-morpholinobenzyl)acetamide
438 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-morpholinophenyl)acetamide
439 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-morpholinobenzyl)acetamide
440 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(piperidin-1-yl)ethyl)acetamide
441 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(dimethylamino)butyl)acetamide
442 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-fluorophenyl)piperazin-1-yl)ethanone
443 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(pyrrolidin-1-yl)piperidin-1-yl)ethanone
444 1-(4-(2-fluorobenzyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
445 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-methyl-2-phenylpiperazin-1-yl)ethanone
446 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-methyl-N-(2-(4-methylpiperazin-1-yl)-1-phenylethyl)acetamide
447 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(2-(pyridin-2-ylmethyl)pyrrolidin-1-yl)ethanone
448 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(2-((6-methylpyridin-2-yl)methyl)pyrrolidin-1-yl)ethanone
449 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(2-(pyridin-2-ylmethyl)piperidin-1-yl)ethanone
450 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-methyl-N-(1-phenyl-2-(pyrrolidin-1-yl)ethyl)acetamide
451 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(4-methoxybenzyl)piperazin-1-yl)ethanone
452 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-(dimethylamino)ethyl)piperazin-1-yl)ethanone
453 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(2-(pyridin-4-ylmethyl)piperidin-1-yl)ethanone
454 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-fluorobenzyl)piperazin-1-yl)ethanone
455 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-methyl-2-phenylpiperazin-1-yl)ethanone
456 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(pyridin-2-ylmethyl)pyrrolidin-1-yl)ethanone
457 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-((4,6-dimethylpyridin-2-yl)methyl)pyrrolidin-1-yl)ethanone
458 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-((6-methylpyridin-2-yl)methyl)pyrrolidin-1-yl)ethanone
459 N-(2-(pyrrolidin-1-yl)ethyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
460 1-(4-benzylpiperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
461 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-phenylpiperazin-1-yl)ethanone
462 1-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
463 N-benzyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-methylpyridin-2-yl)acetamide
464 N-benzyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(6-methylpyridin-2-yl)acetamide
465 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone
466 N-ethyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(pyridin-4-ylmethyl)acetamide
467 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-methyl-1,4-diazepan-1-yl)ethanone
468 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)ethanone
469 1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
470 2-((1-(4-methoxy-2,6-dimethylphenysulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethyl)phenyl)acetamide
471 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(3-(piperidin-1-ylmethyl)phenyl)acetamide
472 N-(4-(2-(1H-benzo[d]imidazol-2-yl)ethyl)phenyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
473 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(2-(4-methylpiperazin-1-yl)benzyl)acetamide
474 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(5-methyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethanone
475 1-(2-(4-(dimethylamino)phenyl)azepan-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
476 1-((R)-3-(dimethylamino)pyrrolidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
477 N-(1-benzylpiperidin-4-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
478 1-(4-benzylpiperazin-1-yl)-2-((1-(2,5-dichlorothiophen-3-ylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
479 2-((2-(4-Methoxy-2,3,6-trimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-phenylpiperazin-1-yl)ethanone
480 1-(4-benzylpiperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
481 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone
482 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-ethyl-N-(pyridin-4-ylmethyl)acetamide
483 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-methyl-1,4-diazepan-1-yl)ethanone
484 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)ethanone
485 1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
486 N-benzyl-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(pyridin-2-yl)acetamide
487 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(5-methyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethanone
488 N-(1-benzylpiperidin-4-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
489 N-benzyl-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(2-(dimethylamino)ethyl)acetamide
490 1-(2-((5-ethylpyridin-2-yl)methyl)pyrrolidin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
491 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(2-methoxyphenyl)piperazin-1-yl)ethanone
492 1-(4-(cyclohexylmethyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
493 N-(3-chloro-4-morpholinophenyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
494 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(1-methyl-1H-benzo[d]imidazol-5-yl)acetamide
495 N-(2-(dimethylamino)-2-(4-(trifluoromethyl)phenyl)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
496 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(2-(pyrrolidin-1-yl)-2-(4-(trifluoromethyl)phenyl)ethyl)acetamide
497 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(pyridin-3-yl)pyrrolidin-1-yl)ethanone
498 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-methoxyphenyl)piperazin-1-yl)ethanone
499 1-(4-(cyclohexylmethyl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
500 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(2-morpholino-1-phenylethyl)acetamide
501 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(1-methyl-1H-indazol-6-yl)acetamide
502 N-(2-(2-chlorophenyl)-2-(pyrrolidin-1-yl)ethyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
503 1-(4-(3,5-dimethoxyphenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
504 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(1-methyl-1H-benzo[d]imidazol-2-yl)acetamide
505 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(1-phenyl-2-(pyrrolidin-1-yl)ethyl)acetamide
506 3-(4-(2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperazin-1-yl)propanenitrile
507 N-benzyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-methylpyridin-2-yl)acetamide
508 N-benzyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(6-methylpyridin-2-yl)acetamide
509 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone
510 N-ethyl-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(pyridin-4-ylmethyl)acetamide
511 1-(4-(3-chlorophenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
512 1-(4-(3,4-dimethylphenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
513 2-(4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperazin-1-yl)nicotinonitrile
514 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(5-(trifluoro methyl)pyridin-2-yl)piperazin-1-yl)ethanone
515 N-benzyl-2-((1-(2,5-dichlorothiophen-3-ylsulfonyl)piperidin-2-yl)methoxy)-N-(6-methylpyridin-2-yl)acetamide
516 1-(4-(2-fluorophenyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
517 1-(4-ethylpiperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
518 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(pyrrolidin-1-yl)piperidin-1-yl)ethanone
519 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-morpholinopiperidin-1-yl)ethanone
520 1-(1,4′-bipiperidin-1′-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)ethanone
521 N-(3-(4-benzylpiperazin-1-yl)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
522 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(3-(piperidin-1-yl)propyl)acetamide
523 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-(pyrrolidin-1-yl)butyl)acetamide
524 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
525 N-(3-(1H-benzo[d]imidazol-2-yl)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
526 1-(4-(benzo[d]thiazol-2-yl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
527 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(2-methyl-1H-imidazol-1-yl)phenyl)acetamide
528 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(4-(dimethylamino)phenyl)pyrrolidin-1-yl)ethanone
529 1-(4-benzyl-1,4-diazepan-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
530 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(dimethylamino)benzyl)-N-isopropylacetamide
531 2-(4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetyl)-1,4-diazepan-1-yl)nicotinonitrile
532 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-methyl-N-(2-(piperidin-1-yl)ethyl)acetamide
533 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)ethyl)piperidin-1-yl)ethanone
534 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(2-(2-morpholinoethyl)piperidin-1-yl)ethanone
535 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(5-methyl-1H-pyrazol-3-yl)acetamide
536 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(5-phenyl-1H-pyrazol-3-yl)acetamide
537 N-(3-(4-chlorophenyl)-1H-pyrazol-5-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
538 N-(4-(3,4-dimethoxyphenyl)-1H-pyrazol-5-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
539 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-(thiophen-2-yl)-1H-pyrazol-5-yl)acetamide
540 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(5-(2-methoxyphenyl)-1H-pyrazol-3-yl)acetamide
541 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(5-(3-methoxyphenyl)-1H-pyrazol-3-yl)acetamide
542 N-(5-(3-fluorophenyl)-1H-pyrazol-3-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
543 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(5-(4-methoxyphenyl)-1H-pyrazol-3-yl)acetamide
544 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-p-tolyl-1H-pyrazol-5-yl)acetamide
545 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-phenyl-1H-pyrazol-5-yl)acetamide
546 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-N-(quinolin-2-yl)acetamide
547 2-((1-(4-methoxyphenylsulfonyl)indolin-2-yl)methoxy)-1-(4-(2-(piperidin-1-yl)ethyl)piperidin-1-yl)ethanone
548 1-(4-(2-(2,5-dimethyl-1H-pyrrol-1-yl)ethyl)piperazin-1-yl)-2-((1-(4-methoxyphenylsulfonyl)indolin-2-yl)methoxy)ethanone
549 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-N-(4-(morpholinomethyl)benzyl)acetamide
550 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone
551 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3,5-dichloropyridin-2-yl)piperazin-1-yl)ethanone
552 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-hydroxyethyl)piperazin-1-yl)ethanone
553 1-(4-(benzo[d]thiazol-2-yl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
554 1-(4-(6-chlorobenzo[d]thiazol-2-yl)piperazin-1-yl)-2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)ethanone
555 N-(4-(4-ethylpiperazin-1-yl)phenyl)-2-((1-(4-methoxyphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
556 2-((1-(4-methoxyphenylsulfonyl)piperidin-2-yl)methoxy)-N-(7-morpholinobenzo[c][1,2,5]oxadiazol-4-yl)acetamide
557 2-((1-(4-methoxyphenylsulfonyl)piperidin-2-yl)methoxy)-N-(3-methyl-4-(2-(piperidin-1-yl)acetamideo)phenyl)acetamide
558 2-((1-(4-methoxyphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(2-phenoxyethyl)piperazin-1-yl)ethanone
559 1-(4-(2-(2,5-dimethyl-1H-pyrrol-1-yl)ethyl)piperazin-1-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
560 1-(4-(3-(dimethylamino)propyl)piperazin-1-yl)-2-((2-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)ethanone
561 N,N-bis(3-(dimethylamino)propyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
562 2-((2-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
563 2-((2-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone
564 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(3-(dimethylamino)propyl)piperazin-1-yl)ethanone
565 2-((1-(2,6-dichlorophenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
566 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(3-(dimethylamino)propyl)piperazin-1-yl)ethanone
567 2-((1-(2,6-dichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
568 1-(4-benzylpiperazin-1-yl)-2-((1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
569 2-((1-(2,6-dichloro-4-(trifluoromethyl)phenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(3-(dimethylamino)propyl)piperazin-1-yl)ethanone
570 2-((1-(2,6-dichloro-4-(trifluoromethyl)phenylsulfonyl)pyrrolidin-2-yl)methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone
571 1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-((1-(2-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)ethanone
572 2-((1-(benzo[b]thiophen-3-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)ethanone
573 2-((1-(benzo[b]thiophen-3-ylsulfonyl)piperidin-2-yl)methoxy)-1-(4-((1-methylpiperidin-4-yl)methyl)piperazin-1-yl)ethanone
574 N—((S)-1-benzylpyrrolidin-3-yl)-2-((1-(2,6-dichloro-4-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methoxy)-N-methylacetamide
575 N-(4-(dimethylamino)benzyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
576 N-(4-(dimethylamino)benzyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
577 N-(4-(dimethylamino)benzyl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetamide
578 N-(4-(dimethylamino)benzyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
579 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)pyrrolidin-2-yl)methoxy)-N-(4-morpholinobenzyl)acetamide
580 N-(4-morpholinobenzyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)pyrrolidin-2-yl)methoxy)acetamide
581 N-(4-morpholinobenzyl)-2-((1-(2,4,6-trichlorophenylsulfonyl)piperidin-2-yl)methoxy)acetamide
in the form of a pure stereoisomer or a mixture of stereoisomers in any mixing ratio, and salts thereof with a physiologically acceptable acid.
20. A process for the preparation of a substituted sulfonamide derivative as claimed in claim 1
Figure US20080153843A1-20080626-C00214
said process comprising forming an amide by reacting a carboxylic acid corresponding to formula L with a primary or secondary amine corresponding to formula M in the presence of a water-removing agent and an organic base in an organic solvent.
21. A process according to claim 20, wherein said water-removing agent is selected from the group consisting of sodium sulfafate, magnesium sulfate, phosphorus oxide, CDI, DCC TBTU, EDCI, HOAt and HOBt; said organic base is selected from the group consisting of DIPEA or pyridine, and said organic solvent is selected from the group consisting of tetrahydrofuran, dichloromethane, diethyl ether, dioxane, dimethyl formamide and acetonitrile.
22. A pharmaceutical composition comprising a compound according to claim 1 and at least one pharmaceutically acceptable carrier or auxiliary substance.
23. A method of treating pain in a patient, said method comprising administering to said patient a therapeutically effective amount of a compound according to claim 1.
24. A method according to claim 23, wherein said patient is a patient suffering pain selected from the group consisting of acute pain, visceral pain, neuropathic pain and chronic pain.
25. A method of treating a disorder or disease state selected from the group consisting of migraine, diabetes, respiratory diseases, inflammatory intestinal diseases, neurological diseases, inflammations of the skin, rheumatic diseases, septic shock, reperfusion syndrome and obesity, or for inhibiting angiogenesis in a patient, said method comprising administering to said patient a therapeutically effective amount of a compound according to claim 1.
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