RU2409364C2 - 3,11b-ЦИС-ДИГИДРОТЕТРАБЕНАЗИН ДЛЯ ЛЕЧЕНИЯ ПРОЛИФЕРАТИВНОГО ЗАБОЛЕВАНИЯ ИЛИ ВОСПАЛЕНИЯ - Google Patents

3,11b-ЦИС-ДИГИДРОТЕТРАБЕНАЗИН ДЛЯ ЛЕЧЕНИЯ ПРОЛИФЕРАТИВНОГО ЗАБОЛЕВАНИЯ ИЛИ ВОСПАЛЕНИЯ Download PDF

Info

Publication number
RU2409364C2
RU2409364C2 RU2008108516/15A RU2008108516A RU2409364C2 RU 2409364 C2 RU2409364 C2 RU 2409364C2 RU 2008108516/15 A RU2008108516/15 A RU 2008108516/15A RU 2008108516 A RU2008108516 A RU 2008108516A RU 2409364 C2 RU2409364 C2 RU 2409364C2
Authority
RU
Russia
Prior art keywords
dihydrotetrabenazine
isomer
cis
cells
isomers
Prior art date
Application number
RU2008108516/15A
Other languages
English (en)
Russian (ru)
Other versions
RU2008108516A (ru
Inventor
Эндрю Джон ДАФФИЛД (GB)
Эндрю Джон ДАФФИЛД
Original Assignee
Байовейл Лэборетериз Интернешнл (Барбадос) Срл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байовейл Лэборетериз Интернешнл (Барбадос) Срл filed Critical Байовейл Лэборетериз Интернешнл (Барбадос) Срл
Publication of RU2008108516A publication Critical patent/RU2008108516A/ru
Application granted granted Critical
Publication of RU2409364C2 publication Critical patent/RU2409364C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2008108516/15A 2005-08-05 2006-08-04 3,11b-ЦИС-ДИГИДРОТЕТРАБЕНАЗИН ДЛЯ ЛЕЧЕНИЯ ПРОЛИФЕРАТИВНОГО ЗАБОЛЕВАНИЯ ИЛИ ВОСПАЛЕНИЯ RU2409364C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0516168.2A GB0516168D0 (en) 2005-08-05 2005-08-05 Pharmaceutical compounds
GB0516168.2 2005-08-05

Publications (2)

Publication Number Publication Date
RU2008108516A RU2008108516A (ru) 2009-09-10
RU2409364C2 true RU2409364C2 (ru) 2011-01-20

Family

ID=34984180

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008108516/15A RU2409364C2 (ru) 2005-08-05 2006-08-04 3,11b-ЦИС-ДИГИДРОТЕТРАБЕНАЗИН ДЛЯ ЛЕЧЕНИЯ ПРОЛИФЕРАТИВНОГО ЗАБОЛЕВАНИЯ ИЛИ ВОСПАЛЕНИЯ

Country Status (23)

Country Link
US (1) US20090275605A1 (cg-RX-API-DMAC7.html)
EP (2) EP1964565A1 (cg-RX-API-DMAC7.html)
JP (1) JP2009503045A (cg-RX-API-DMAC7.html)
KR (1) KR20080033501A (cg-RX-API-DMAC7.html)
CN (1) CN101321528B (cg-RX-API-DMAC7.html)
AT (1) ATE412414T1 (cg-RX-API-DMAC7.html)
AU (1) AU2006277836B8 (cg-RX-API-DMAC7.html)
CA (1) CA2620952A1 (cg-RX-API-DMAC7.html)
CY (1) CY1108729T1 (cg-RX-API-DMAC7.html)
DE (1) DE602006003415D1 (cg-RX-API-DMAC7.html)
DK (1) DK1861100T3 (cg-RX-API-DMAC7.html)
ES (1) ES2317564T3 (cg-RX-API-DMAC7.html)
GB (1) GB0516168D0 (cg-RX-API-DMAC7.html)
HR (1) HRP20090017T3 (cg-RX-API-DMAC7.html)
MX (1) MX2008001546A (cg-RX-API-DMAC7.html)
NZ (1) NZ566010A (cg-RX-API-DMAC7.html)
PL (1) PL1861100T3 (cg-RX-API-DMAC7.html)
PT (1) PT1861100E (cg-RX-API-DMAC7.html)
RS (1) RS50720B (cg-RX-API-DMAC7.html)
RU (1) RU2409364C2 (cg-RX-API-DMAC7.html)
SI (1) SI1861100T1 (cg-RX-API-DMAC7.html)
WO (1) WO2007017643A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA200801171B (cg-RX-API-DMAC7.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2410947B (en) * 2004-02-11 2008-09-17 Cambridge Lab Ltd Pharmaceutical compounds
GB0514501D0 (en) * 2005-07-14 2005-08-24 Cambridge Lab Ireland Ltd Pharmaceutical compounds
PT2081929E (pt) 2006-11-08 2013-04-15 Neurocrine Biosciences Inc Compostos de 3-isobutil-9,10-dimetoxi- 1,3,4,6,7,11b-hexahidro-2h-pirido[2,1-a]isoquinolin- 2-ol substituídos e métodos com estes relacionados
GB0721669D0 (en) * 2007-11-02 2007-12-12 Cambridge Lab Ireland Ltd Pharmaceutical compounds
GB0810857D0 (en) * 2008-06-13 2008-07-23 Cambridge Lab Ireland Ltd Pharmaceutical compounds
US20110053866A1 (en) * 2008-08-12 2011-03-03 Biovail Laboratories International (Barbados) S.R.L. Pharmaceutical compositions
GB2462611A (en) * 2008-08-12 2010-02-17 Cambridge Lab Pharmaceutical composition comprising tetrabenazine
GB2463452A (en) * 2008-09-08 2010-03-17 Cambridge Lab Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof
GB2463451A (en) 2008-09-08 2010-03-17 Cambridge Lab 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia
GB2463283A (en) * 2008-09-08 2010-03-10 Cambridge Lab 3,11b-cis-dihydrotetrabenazine for use in treating asthma
CA2801061A1 (en) 2010-06-01 2011-12-08 Auspex Pharmaceuticals, Inc. Benzoquinolone inhibitors of vmat2
CN102285984B (zh) * 2010-11-25 2012-10-10 江苏威凯尔医药科技有限公司 (2R,3R,11bR)-二氢丁苯那嗪及相关化合物的制备方法
EP3099299A4 (en) 2014-01-27 2017-10-04 Auspex Pharmaceuticals, Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
MA41177A (fr) * 2014-12-15 2017-10-24 Esteve Labor Dr Utilisation de ligands des récepteurs sigma dans l'arthrose
US10550120B2 (en) 2016-03-25 2020-02-04 Tohoku University Indole alkaloid compound having immune checkpoint inhibitory action
CN109283263B (zh) * 2017-07-21 2019-06-25 南京正大天晴制药有限公司 用于雷替曲塞合成质量控制的检测分析方法
CN109283279B (zh) * 2017-07-21 2019-11-01 南京正大天晴制药有限公司 通过高效液相色谱法分离测定雷替曲塞及其对映异构体的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2830993A (en) * 1958-04-15 Quinolizine derivatives

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123609A (en) * 1964-03-03 Benzo
US3053845A (en) * 1962-09-11 Benzofykedocolines
US3095419A (en) * 1963-06-25 Process for preparing z-oxo-j-
US2954382A (en) * 1960-09-27 Xpreparation of hexahydrobenzoquinol-
US3132147A (en) * 1964-05-05
US2843591A (en) 1958-07-15 Method for preparing same
US3209005A (en) * 1965-09-28 Hexahydro-llbh-benzo[a] quinolizines and processes therefor
US3159638A (en) * 1964-12-01 Xcha-chj
US3009918A (en) * 1961-11-21 Chz ch
US3314966A (en) * 1967-04-18 Substituted benzo[a]quinolizines
US3079395A (en) * 1963-02-26 Novel z-oxq-benzoquinoliaine
US3045021A (en) * 1959-09-24 1962-07-17 Hoffmann La Roche Preparation of substituted 2-oxobenzoquinolizines
GB999092A (en) * 1959-11-24 1965-07-21 Wellcome Found Method for making benzo(a)-quinolizine derivatives
US3375254A (en) * 1961-09-29 1968-03-26 Burroughs Wellcome Co Manufacture of 1, 2, 3, 4, 6, 7-hexahydro-2-oxo-11bh-benzo(a)quinolizines
US3105079A (en) * 1961-12-29 1963-09-24 Pfizer & Co C 10-aminobenzopyridocolines
US3390152A (en) * 1965-10-21 1968-06-25 Abbott Lab 9, 10-alkoxy-3-alkyl-2, 2-(dithiosubstituted)-benzoquinolizines
US3634431A (en) * 1969-12-22 1972-01-11 Miles Lab Acylated and alkylated derivatives of 2-aminohexahydrobenzo(a)quinolizines
US3635986A (en) * 1969-12-22 1972-01-18 Miles Lab 2-substituted amino-hexahydrobenzo(a)quinolizines
YU264675A (en) * 1974-10-23 1982-05-31 Chinoin Gyogyszer Es Vegyeszet Process for obtaining benzo (a)-quinolizidine derivatives
GB1513824A (en) * 1975-05-22 1978-06-14 Wyeth John & Brother Ltd 1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative
US4133812A (en) * 1975-11-21 1979-01-09 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Process for producing benzo (a) quinolizine derivatives
US4304913A (en) * 1978-11-20 1981-12-08 Miles Laboratories, Inc. Trans-2-substituted-amido-hexahydrobenzo [A]quinolizines
US4353656A (en) * 1980-10-14 1982-10-12 Xerox Corporation Moving coil, multiple energy print hammer system including a closed loop servo
US4778054A (en) * 1982-10-08 1988-10-18 Glaxo Group Limited Pack for administering medicaments to patients
FI88112C (fi) * 1985-07-30 1993-04-13 Glaxo Group Ltd Anordning foer administrering av laekemedel till patienter
GB9004781D0 (en) * 1990-03-02 1990-04-25 Glaxo Group Ltd Device
US6087376A (en) * 1997-02-05 2000-07-11 University Of Kentucky Research Foundation Use of lobeline compounds in the treatment of central nervous system diseases and pathologies
FR2794742B1 (fr) * 1999-06-11 2005-06-03 Sanofi Synthelabo Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant
US6632666B2 (en) * 2000-01-14 2003-10-14 Biolife Solutions, Inc. Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media
WO2001079198A1 (en) * 2000-04-18 2001-10-25 Agouron Pharmaceuticals, Inc. Pyrazoles for inhibiting protein kinase
EP2529730A1 (en) * 2003-06-16 2012-12-05 ANDRX Pharmaceuticals LLC. Oral sustained-release composition
GB2410947B (en) * 2004-02-11 2008-09-17 Cambridge Lab Ltd Pharmaceutical compounds
KR100682506B1 (ko) * 2005-01-18 2007-02-15 (주)젠크로스 프라지콴텔, 또는 이의 염을 포함하는 약학 조성물
GB0514501D0 (en) * 2005-07-14 2005-08-24 Cambridge Lab Ireland Ltd Pharmaceutical compounds
GB0810857D0 (en) * 2008-06-13 2008-07-23 Cambridge Lab Ireland Ltd Pharmaceutical compounds
GB2462611A (en) * 2008-08-12 2010-02-17 Cambridge Lab Pharmaceutical composition comprising tetrabenazine
US20110053866A1 (en) * 2008-08-12 2011-03-03 Biovail Laboratories International (Barbados) S.R.L. Pharmaceutical compositions
GB2463451A (en) * 2008-09-08 2010-03-17 Cambridge Lab 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia
GB2463283A (en) * 2008-09-08 2010-03-10 Cambridge Lab 3,11b-cis-dihydrotetrabenazine for use in treating asthma
GB2463452A (en) * 2008-09-08 2010-03-17 Cambridge Lab Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2830993A (en) * 1958-04-15 Quinolizine derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Kilbourn М et al. Binding of alpha-dihydrotetrabenazine to the vesicular monoamine transporter is stereospecific. Eur J Pharmacol. 1995 May 24; 278(3):249-52. Mehvar R. et al. Pharmacokinetics of tetrabenazine and its major metabolite in man and rat. Bioavailability and dose dependency studiesDrug Metab Dispos. 1987 Mar-Apr; 15(2):250-5. (реферат) [он-лайн] [найдено 2010-02-27] Найдено из базы данных PubMed PMID:2882986. *
ХАРКЕВИЧ Д.А. Фармакология. - М.: Медицина, 1996 с.163-170. *

Also Published As

Publication number Publication date
CY1108729T1 (el) 2014-04-09
DE602006003415D1 (de) 2008-12-11
HK1111084A1 (en) 2008-08-01
CN101321528A (zh) 2008-12-10
NZ566010A (en) 2010-05-28
ES2317564T3 (es) 2009-04-16
US20090275605A1 (en) 2009-11-05
EP1861100B1 (en) 2008-10-29
DK1861100T3 (da) 2008-12-15
HRP20090017T3 (hr) 2009-03-31
WO2007017643A1 (en) 2007-02-15
RS50720B (sr) 2010-08-31
CN101321528B (zh) 2011-05-25
ZA200801170B (en) 2009-12-30
AU2006277836A1 (en) 2007-02-15
JP2009503045A (ja) 2009-01-29
ATE412414T1 (de) 2008-11-15
ZA200801171B (en) 2009-08-26
GB0516168D0 (en) 2005-09-14
EP1964565A1 (en) 2008-09-03
AU2006277836B8 (en) 2011-12-08
AU2006277836B2 (en) 2011-11-10
CA2620952A1 (en) 2007-02-15
PL1861100T3 (pl) 2009-06-30
KR20080033501A (ko) 2008-04-16
RU2008108516A (ru) 2009-09-10
SI1861100T1 (sl) 2009-04-30
EP1861100A1 (en) 2007-12-05
MX2008001546A (es) 2008-04-04
PT1861100E (pt) 2008-12-26

Similar Documents

Publication Publication Date Title
RU2409364C2 (ru) 3,11b-ЦИС-ДИГИДРОТЕТРАБЕНАЗИН ДЛЯ ЛЕЧЕНИЯ ПРОЛИФЕРАТИВНОГО ЗАБОЛЕВАНИЯ ИЛИ ВОСПАЛЕНИЯ
CA2942883C (en) 1,3-benzodioxole derivative
JP6920295B2 (ja) テトラヒドロナフタレンエストロゲン受容体モジュレーター及びその使用
CN113164495B (zh) E3连接酶的共价靶向
US11952349B2 (en) Anti-cancer nuclear hormone receptor-targeting compounds
EP3999507B1 (en) Imidazo[4,5-c]pyridine derivatives as toll-like receptor agonsits
JP2021515010A (ja) フェロトーシス誘導活性を有する化合物およびそれらの使用方法
KR20230160299A (ko) 항암 핵 호르몬 수용체 표적화 화합물
TW202012384A (zh) 特定芳基普拉二烯內酯化合物及其使用方法
EP2986612A1 (en) Deuterated morphine derivatives
KR20210027382A (ko) 접히지 않은 단백질 반응의 활성화제
US20240139149A1 (en) Therapeutic uses of urolithin derivatives
WO2008052352A1 (en) Substituted quinone indoleamine 2,3-dioxygenase (ido) inhibitors and syntheses and uses therefor
HK1121405A (en) 3,11b-cis-dihydrotetrabenazine for the treatment of a proliferative disease or an inflammation
JP2025508983A (ja) 重水素化レチノイド化合物ならびにその合成および使用
HK1111084B (en) 3,11b-cis-dihydrotetrabenazine for the treatment of a proliferative disease or an inflammation
JP2025510303A (ja) ラノステロール合成酵素の低分子阻害剤
EA048477B1 (ru) Противоопухолевые соединения, направляющие на ядерный рецептор гормона

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20120805