RU2363459C2 - Средства для введения в роговицу глаз или внутрь стромы для лечения или предотвращения офтальмологических нарушений - Google Patents

Средства для введения в роговицу глаз или внутрь стромы для лечения или предотвращения офтальмологических нарушений Download PDF

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Publication number
RU2363459C2
RU2363459C2 RU2004129761/14A RU2004129761A RU2363459C2 RU 2363459 C2 RU2363459 C2 RU 2363459C2 RU 2004129761/14 A RU2004129761/14 A RU 2004129761/14A RU 2004129761 A RU2004129761 A RU 2004129761A RU 2363459 C2 RU2363459 C2 RU 2363459C2
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RU
Russia
Prior art keywords
urea
cornea
injection
pharmaceutical composition
corneal
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RU2004129761/14A
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English (en)
Russian (ru)
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RU2004129761A (ru
Inventor
Виккен КАРАГЕОЗЯН (US)
Виккен КАРАГЕОЗЯН
Давид КАСТИЛЛЕДЖОС (US)
Давид КАСТИЛЛЕДЖОС
Джон ПАРК (US)
Джон ПАРК
Габриэль Артуро Карпио АРАГОН (MX)
Габриэль Артуро Карпио АРАГОН
Хосе Луис Гутьеррес ФЛОРЕС (MX)
Хосе Луис Гутьеррес ФЛОРЕС
Original Assignee
Витрио-Ретинол Текнолоджиз, Инк.
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Publication of RU2004129761A publication Critical patent/RU2004129761A/ru
Application granted granted Critical
Publication of RU2363459C2 publication Critical patent/RU2363459C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
RU2004129761/14A 2002-03-14 2003-03-14 Средства для введения в роговицу глаз или внутрь стромы для лечения или предотвращения офтальмологических нарушений RU2363459C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36397902P 2002-03-14 2002-03-14
US60/363,979 2002-03-14

Publications (2)

Publication Number Publication Date
RU2004129761A RU2004129761A (ru) 2005-06-10
RU2363459C2 true RU2363459C2 (ru) 2009-08-10

Family

ID=28041849

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2004129761/14A RU2363459C2 (ru) 2002-03-14 2003-03-14 Средства для введения в роговицу глаз или внутрь стромы для лечения или предотвращения офтальмологических нарушений

Country Status (10)

Country Link
EP (1) EP1482922A4 (es)
JP (1) JP2005522464A (es)
KR (1) KR20040094793A (es)
CN (1) CN1642536A (es)
AU (2) AU2003213858A1 (es)
BR (1) BR0308403A (es)
CA (1) CA2478965A1 (es)
MX (1) MXPA04008776A (es)
RU (1) RU2363459C2 (es)
WO (1) WO2003077898A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030199574A1 (en) 2000-03-02 2003-10-23 Vitreo-Retinal Technologies, Inc. Treatment of ophthalmic disorders using urea and urea derivatives
CN101231121B (zh) * 2007-01-24 2012-06-13 泰州乐金电子冷机有限公司 冰箱用托盘拉出装置
WO2011111876A1 (en) * 2010-03-12 2011-09-15 Riken Clearing reagent for biological material, and use thereof
EP2711682B1 (en) 2011-05-20 2019-07-10 Riken Clarifying reagent for biological materials and use thereof
JP6433901B2 (ja) 2013-08-14 2018-12-05 国立研究開発法人理化学研究所 光透過性に優れた生物材料を調製するための組成物およびその利用
DE102013110608A1 (de) * 2013-09-26 2015-03-26 Florian Lang Substanz zur Hemmung von Gewebskalzifizierung, Gewebsfibrosierung und altersassoziierten Erkrankungen
CN110237238A (zh) * 2019-08-02 2019-09-17 山东省眼科研究所 Manf在促进角膜损伤修复中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470881A (en) * 1993-09-09 1995-11-28 West Virginia University Research Corporation Urea ophthalmic ointment and solution
JP2002538125A (ja) * 1999-03-02 2002-11-12 ビトレオ−レチナール テクノロジーズ インコーポレイテッド 眼の障害を治療又は予防するための硝子体内投与用薬剤
CA2475338C (en) * 2002-02-13 2014-08-19 Vitreo-Retinal Technologies, Inc. Treatment of ophthalmic disorders using urea and urea derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ЧАЛАНОВА Р.И. Фонофорез протеолитических ферментов (лекозима и коллализина) в лечении ожогов глаз и послеожоговых помутнений роговой оболочки. Автореф. дисс. к.м.н., 1990. CHARLTON JF. "Topical urea as a treatment for non-infectious keratopathy" Acta Ophthalmol Scand. 1996 Fug; 74(4):391-4. DANOPOULOS ED et al. "Effect of utea treatment in malignancies of the conjunctiva and cornea". Ophthalmologica 1979; 178(4): 198-203. ALIO J et al. "Effect of topical antioxidant therapy on experimental infectious keratitis". Cornea, 1995 Mar; 14(2):175-9. *

Also Published As

Publication number Publication date
KR20040094793A (ko) 2004-11-10
EP1482922A1 (en) 2004-12-08
AU2003213858A1 (en) 2003-09-29
AU2009201897B2 (en) 2011-09-15
RU2004129761A (ru) 2005-06-10
JP2005522464A (ja) 2005-07-28
WO2003077898A1 (en) 2003-09-25
EP1482922A4 (en) 2005-06-08
BR0308403A (pt) 2005-01-18
CA2478965A1 (en) 2003-09-25
MXPA04008776A (es) 2005-04-19
CN1642536A (zh) 2005-07-20
AU2009201897A1 (en) 2009-06-04

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FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20070604

FZ9A Application not withdrawn (correction of the notice of withdrawal)

Effective date: 20080429