RU2362555C2 - Применение замещенных цианопирролидинов и содержащих их комбинированных препаратов для лечения гиперлипидемии и ассоциированных заболеваний - Google Patents

Применение замещенных цианопирролидинов и содержащих их комбинированных препаратов для лечения гиперлипидемии и ассоциированных заболеваний Download PDF

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Publication number
RU2362555C2
RU2362555C2 RU2004139029/14A RU2004139029A RU2362555C2 RU 2362555 C2 RU2362555 C2 RU 2362555C2 RU 2004139029/14 A RU2004139029/14 A RU 2004139029/14A RU 2004139029 A RU2004139029 A RU 2004139029A RU 2362555 C2 RU2362555 C2 RU 2362555C2
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RU
Russia
Prior art keywords
inhibitor
compound
formula
vitamin
agent
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RU2004139029/14A
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English (en)
Russian (ru)
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RU2004139029A (ru
Inventor
Дейвид Гренвилл ХОЛМС (CH)
Дейвид Гренвилл ХОЛМС
Томас Эдуард ХЬЮЗ (US)
Томас Эдуард ХЬЮЗ
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Новартис Аг
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Publication of RU2004139029A publication Critical patent/RU2004139029A/ru
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Publication of RU2362555C2 publication Critical patent/RU2362555C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2004139029/14A 2002-06-03 2003-06-02 Применение замещенных цианопирролидинов и содержащих их комбинированных препаратов для лечения гиперлипидемии и ассоциированных заболеваний RU2362555C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38522002P 2002-06-03 2002-06-03
US60/385,220 2002-06-03

Publications (2)

Publication Number Publication Date
RU2004139029A RU2004139029A (ru) 2005-08-27
RU2362555C2 true RU2362555C2 (ru) 2009-07-27

Family

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Application Number Title Priority Date Filing Date
RU2004139029/14A RU2362555C2 (ru) 2002-06-03 2003-06-02 Применение замещенных цианопирролидинов и содержащих их комбинированных препаратов для лечения гиперлипидемии и ассоциированных заболеваний

Country Status (25)

Country Link
US (2) US20050176806A1 (enExample)
EP (1) EP1513519B1 (enExample)
JP (2) JP2005532338A (enExample)
KR (1) KR20050012771A (enExample)
CN (2) CN100402026C (enExample)
AT (1) ATE422884T1 (enExample)
AU (2) AU2003245903B2 (enExample)
BR (1) BR0311535A (enExample)
CA (1) CA2487297C (enExample)
CY (1) CY1112800T1 (enExample)
DE (1) DE60326232D1 (enExample)
DK (1) DK1513519T3 (enExample)
EC (1) ECSP045469A (enExample)
ES (1) ES2321600T3 (enExample)
IL (1) IL165181A (enExample)
MX (1) MXPA04012149A (enExample)
NO (1) NO333585B1 (enExample)
NZ (1) NZ536832A (enExample)
PL (1) PL210408B1 (enExample)
PT (1) PT1513519E (enExample)
RU (1) RU2362555C2 (enExample)
SG (1) SG154333A1 (enExample)
SI (1) SI1513519T1 (enExample)
WO (1) WO2003101448A1 (enExample)
ZA (1) ZA200409136B (enExample)

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AR041089A1 (es) * 2003-05-15 2005-05-04 Merck & Co Inc Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
JP5122144B2 (ja) * 2004-01-20 2013-01-16 ノバルティス アーゲー 直接圧縮製剤および方法
DOP2006000008A (es) 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
WO2006083214A1 (en) * 2005-02-02 2006-08-10 Astrazeneca Ab Pharmaceutical composition comprising a p2x7 receptor antagonist and a hmg-coa reductase inhibitor
MX2007011453A (es) 2005-04-22 2008-02-12 Alantos Pharmaceuticals Holding Inc Inhibidores de la dipeptidil peptidasa-iv.
PE20071221A1 (es) 2006-04-11 2007-12-14 Arena Pharm Inc Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
WO2008097535A2 (en) * 2007-02-08 2008-08-14 Merck & Co., Inc. Method of treating atherosclerosis, dyslipidemias and related conditions
EP2146210A1 (en) 2008-04-07 2010-01-20 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY
AR077642A1 (es) 2009-07-09 2011-09-14 Arena Pharm Inc Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
JP2013523819A (ja) 2010-04-06 2013-06-17 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｇｐｒ１１９レセプターのモジュレーターおよびそれに関連する障害の処置
CN103221410B (zh) 2010-09-22 2017-09-15 艾尼纳制药公司 Gpr119受体调节剂和对与其相关的障碍的治疗
KR101298788B1 (ko) * 2011-03-15 2013-08-22 보령제약 주식회사 안정성이 개선된 복합제제
US20140018371A1 (en) 2011-04-01 2014-01-16 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012145361A1 (en) 2011-04-19 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145604A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145603A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013055910A1 (en) 2011-10-12 2013-04-18 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
CN107683135A (zh) 2015-03-09 2018-02-09 因特克林医疗有限公司 用于治疗非酒精性脂肪肝疾病和/或脂肪营养不良的方法
AU2018249822A1 (en) 2017-04-03 2019-10-31 Coherus Biosciences Inc. PPArgamma agonist for treatment of progressive supranuclear palsy
EA202192328A1 (ru) * 2019-03-22 2022-02-21 Раш Юниверсити Медикал Сентер Комбинация назальной доставки генов и пероральной доставки коричной кислоты, олеамида или гемфиброзила для лечения лизосомных болезней накопления

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA021236B1 (ru) * 2012-10-03 2015-05-29 Дафот Энтерпраизес Лимитед Nα-АЦИЛЬНЫЕ ПРОИЗВОДНЫЕ АМИНОАЦИЛ-2-ЦИАНОПИРРОЛИДИНА - ИНГИБИТОРЫ ПРОЛИЛЭНДОПЕПТИДАЗЫ И ДИПЕПТИДИЛПЕПТИДАЗЫ-IV, ОБЛАДАЮЩИЕ ГИПОГЛИКЕМИЧЕСКИМ, ПРОТИВОГИПОКСИЧЕСКИМ, НЕЙРОПРОТЕКТОРНЫМ И УЛУЧШАЮЩИМ КОГНИТИВНЫЕ ФУНКЦИИ ДЕЙСТВИЕМ

Also Published As

Publication number Publication date
ES2321600T3 (es) 2009-06-09
PL210408B1 (pl) 2012-01-31
BR0311535A (pt) 2005-02-22
AU2003245903A1 (en) 2003-12-19
IL165181A (en) 2010-06-16
PT1513519E (pt) 2009-05-06
IL165181A0 (en) 2005-12-18
AU2003245903B2 (en) 2006-11-30
EP1513519A1 (en) 2005-03-16
ZA200409136B (en) 2005-07-27
HK1074794A1 (en) 2005-11-25
SG154333A1 (en) 2009-08-28
CA2487297A1 (en) 2003-12-11
US20120014907A1 (en) 2012-01-19
AU2006246483B9 (en) 2010-08-12
JP2010155866A (ja) 2010-07-15
JP2005532338A (ja) 2005-10-27
ATE422884T1 (de) 2009-03-15
PL374016A1 (en) 2005-09-19
CN1658867A (zh) 2005-08-24
MXPA04012149A (es) 2005-04-19
CY1112800T1 (el) 2016-02-10
CN101273987A (zh) 2008-10-01
RU2004139029A (ru) 2005-08-27
SI1513519T1 (sl) 2009-06-30
CA2487297C (en) 2011-08-09
CN100402026C (zh) 2008-07-16
NO333585B1 (no) 2013-07-15
AU2006246483A1 (en) 2006-12-21
DK1513519T3 (da) 2009-06-02
EP1513519B1 (en) 2009-02-18
AU2006246483B2 (en) 2010-06-24
NZ536832A (en) 2006-11-30
WO2003101448A1 (en) 2003-12-11
ECSP045469A (es) 2005-01-28
US20050176806A1 (en) 2005-08-11
DE60326232D1 (de) 2009-04-02
KR20050012771A (ko) 2005-02-02
NO20045452L (no) 2005-03-01

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