RU2351596C2 - Производные n-[гетероарил(пиперидин-2-ил)метил]бензамида и их применение в терапии - Google Patents
Производные n-[гетероарил(пиперидин-2-ил)метил]бензамида и их применение в терапии Download PDFInfo
- Publication number
- RU2351596C2 RU2351596C2 RU2006116887/04A RU2006116887A RU2351596C2 RU 2351596 C2 RU2351596 C2 RU 2351596C2 RU 2006116887/04 A RU2006116887/04 A RU 2006116887/04A RU 2006116887 A RU2006116887 A RU 2006116887A RU 2351596 C2 RU2351596 C2 RU 2351596C2
- Authority
- RU
- Russia
- Prior art keywords
- methyl
- trifluoromethyl
- piperidin
- chloro
- benzamide
- Prior art date
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- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 57
- 150000003839 salts Chemical class 0.000 claims abstract description 14
- 239000002253 acid Substances 0.000 claims abstract description 12
- 230000000694 effects Effects 0.000 claims abstract description 6
- 125000005843 halogen group Chemical group 0.000 claims abstract description 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 5
- 239000003112 inhibitor Substances 0.000 claims abstract description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 4
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 claims abstract description 3
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 claims abstract description 3
- 125000001544 thienyl group Chemical group 0.000 claims abstract description 3
- 238000004519 manufacturing process Methods 0.000 claims abstract 3
- 239000012458 free base Substances 0.000 claims abstract 2
- -1 2-Methyl-N - [(1-methyl-piperidin-2-yl) -thiophen-3-yl-methyl] -3-trifluoromethyl-benzamide Chemical compound 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
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- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
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- 125000001153 fluoro group Chemical group F* 0.000 description 1
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- 125000000623 heterocyclic group Chemical group 0.000 description 1
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 1
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- 235000019359 magnesium stearate Nutrition 0.000 description 1
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- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0312142 | 2003-10-17 | ||
| FR0312142A FR2861073B1 (fr) | 2003-10-17 | 2003-10-17 | Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006116887A RU2006116887A (ru) | 2007-11-27 |
| RU2351596C2 true RU2351596C2 (ru) | 2009-04-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| RU2006116887/04A RU2351596C2 (ru) | 2003-10-17 | 2004-10-15 | Производные n-[гетероарил(пиперидин-2-ил)метил]бензамида и их применение в терапии |
Country Status (26)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2536688C2 (ru) * | 2010-04-23 | 2014-12-27 | Донг-А Фарм.Ко., Лтд. | Новые бензамидные производные |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2842804B1 (fr) | 2002-07-29 | 2004-09-03 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| FR2861074B1 (fr) * | 2003-10-17 | 2006-04-07 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| FR2861071B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique |
| CN101072762B (zh) * | 2004-12-09 | 2010-06-23 | 弗·哈夫曼-拉罗切有限公司 | 苯基-哌嗪甲酮衍生物 |
| GB0428233D0 (en) * | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Compounds |
| PE20061156A1 (es) | 2004-12-23 | 2006-12-16 | Glaxo Group Ltd | Derivados de benzamida como agentes inhibidores del transportador de glicina |
| WO2006067414A2 (en) * | 2004-12-23 | 2006-06-29 | Glaxo Group Limited | Glycine transport inhibitors |
| AR057350A1 (es) * | 2005-06-06 | 2007-11-28 | Merck Sharp & Dohme | Derivados de ciclohexanosulfonilo como inhibidores de glyt1 para tratar esquizofrenia. composiciones farmaceuticas |
| FR2906251B1 (fr) * | 2006-09-22 | 2008-11-07 | Sanofi Aventis Sa | Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique |
| ATE449062T1 (de) * | 2007-02-22 | 2009-12-15 | Indena Spa | Verfahren zur herstellung von (2r,3s)-3- phenylisoserin-methylester-acetatsalz |
| MX2009014235A (es) | 2007-08-22 | 2010-04-27 | Abbott Gmbh & Co Kg | 4-bencilaminoquinolonas, composiciones farmaceuticas que las contiene y su uso. |
| ES2397764T3 (es) | 2008-04-01 | 2013-03-11 | Abbott Gmbh & Co. Kg | Tetrahidroisoquinolinas, composiciones farmacéuticas que las contienen, y su uso en terapia |
| WO2010087761A1 (en) * | 2009-01-28 | 2010-08-05 | Astrazeneca Ab | 2-aza-bicyclo[2.2.2]octane compounds and uses thereof |
| TW201038569A (en) | 2009-02-16 | 2010-11-01 | Abbott Gmbh & Co Kg | Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy |
| AR075442A1 (es) | 2009-02-16 | 2011-03-30 | Abbott Gmbh & Co Kg | Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia |
| JP5618047B2 (ja) * | 2010-01-29 | 2014-11-05 | 国立大学法人千葉大学 | ポジトロン断層撮影法およびポジトロン放出化合物 |
| US8877794B2 (en) | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8846743B2 (en) | 2010-08-13 | 2014-09-30 | Abbott Laboratories | Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9045459B2 (en) | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9051280B2 (en) | 2010-08-13 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8883839B2 (en) | 2010-08-13 | 2014-11-11 | Abbott Laboratories | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9309200B2 (en) | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| WO2013020930A1 (en) | 2011-08-05 | 2013-02-14 | Abbott Gmbh & Co. Kg | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| WO2013072520A1 (en) | 2011-11-18 | 2013-05-23 | AbbVie Deutschland GmbH & Co. KG | N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9242938B2 (en) | 2011-11-22 | 2016-01-26 | Beijing Medisan Technology Co., Ltd | Glycine reuptake inhibitor and use thereof |
| TR201806764T4 (tr) * | 2011-11-29 | 2018-06-21 | Vivozon Inc | Yeni benzamid türevi ve bunun kullanımı. |
| US9365512B2 (en) | 2012-02-13 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9650334B2 (en) | 2013-03-15 | 2017-05-16 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| KR20160062164A (ko) | 2013-10-17 | 2016-06-01 | 아비에 도이치란트 게엠베하 운트 콤파니 카게 | 아미노크로만, 아미노티오크로만 및 아미노-1,2,3,4-테트라하이드로퀴놀린 유도체, 이들을 포함하는 약제학적 조성물, 및 치료에서 이들의 용도 |
| CA2924699A1 (en) | 2013-10-17 | 2015-04-23 | AbbVie Deutschland GmbH & Co. KG | Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9550754B2 (en) | 2014-09-11 | 2017-01-24 | AbbVie Deutschland GmbH & Co. KG | 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy |
| CN108218846A (zh) * | 2016-12-22 | 2018-06-29 | 四川海思科制药有限公司 | 噻吩衍生物的新固态形式及其制备方法和用途 |
| GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714740D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201903832D0 (en) * | 2019-03-20 | 2019-05-01 | Atrogi Ab | New compounds and methods |
| US20220233492A1 (en) * | 2019-06-20 | 2022-07-28 | Vivozon Inc. | Method of preventing or treating postoperative pain |
| CN114478360B (zh) * | 2022-02-10 | 2023-08-15 | 江苏海洋大学 | 一种苯甲酰胺类衍生物及其制备方法和应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001081308A2 (en) * | 2000-04-20 | 2001-11-01 | Nps Allelix Corp. | Aminopiperidines for use as glyt-1 inhibitors |
| RU2000124676A (ru) * | 1998-02-27 | 2002-08-27 | Ф.Хоффманн-Ля Рош Аг | Производные 2-арилэтил-(пиперидин-4-илметил)-амина в качестве антагонистов мускаринового рецептора |
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| US5254569A (en) * | 1991-01-14 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | (Amidomethyl)nitrogen heterocyclic analgesics |
| JP3026845B2 (ja) * | 1991-02-20 | 2000-03-27 | 日清製粉株式会社 | ピペリジン誘導体 |
| US6319920B1 (en) * | 1998-02-27 | 2001-11-20 | Syntex (U.S.A.) Llc | 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives |
| FR2838739B1 (fr) * | 2002-04-19 | 2004-05-28 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl)benzamide, leur preparation et leur application en therapeutique |
| FR2842804B1 (fr) * | 2002-07-29 | 2004-09-03 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
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2003
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2004
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- 2004-10-15 DK DK04791552T patent/DK1680418T3/da active
- 2004-10-15 NZ NZ547165A patent/NZ547165A/en not_active IP Right Cessation
- 2004-10-15 EP EP04791552A patent/EP1680418B1/fr not_active Expired - Lifetime
- 2004-10-15 CA CA002542370A patent/CA2542370A1/fr not_active Abandoned
- 2004-10-15 PL PL04791552T patent/PL1680418T3/pl unknown
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2000124676A (ru) * | 1998-02-27 | 2002-08-27 | Ф.Хоффманн-Ля Рош Аг | Производные 2-арилэтил-(пиперидин-4-илметил)-амина в качестве антагонистов мускаринового рецептора |
| WO2001081308A2 (en) * | 2000-04-20 | 2001-11-01 | Nps Allelix Corp. | Aminopiperidines for use as glyt-1 inhibitors |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2536688C2 (ru) * | 2010-04-23 | 2014-12-27 | Донг-А Фарм.Ко., Лтд. | Новые бензамидные производные |
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