RU2350323C2 - Способ кардиопротекции и нейропротекции внутривенным введением галогенсодержащего летучего анестезирующего средства - Google Patents

Способ кардиопротекции и нейропротекции внутривенным введением галогенсодержащего летучего анестезирующего средства Download PDF

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RU2350323C2
RU2350323C2 RU2005114008/14A RU2005114008A RU2350323C2 RU 2350323 C2 RU2350323 C2 RU 2350323C2 RU 2005114008/14 A RU2005114008/14 A RU 2005114008/14A RU 2005114008 A RU2005114008 A RU 2005114008A RU 2350323 C2 RU2350323 C2 RU 2350323C2
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patient
tissue
anesthetic
formulation
isoflurane
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RU2005114008/14A
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Russian (ru)
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RU2005114008A (ru
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Рауль ТРИЛЛО (US)
Рауль ТРИЛЛО
Ральф ЛЕССОР (US)
Ральф ЛЕССОР
Сатиш ПЕДЖАВЕР (US)
Сатиш ПЕДЖАВЕР
Навнит ПУРИ (US)
Навнит ПУРИ
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Бакстер Интернэшнл Инк.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/02Halogenated hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2005114008/14A 2002-10-11 2003-10-09 Способ кардиопротекции и нейропротекции внутривенным введением галогенсодержащего летучего анестезирующего средства RU2350323C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41793402P 2002-10-11 2002-10-11
US60/417,934 2002-10-11

Publications (2)

Publication Number Publication Date
RU2005114008A RU2005114008A (ru) 2005-10-27
RU2350323C2 true RU2350323C2 (ru) 2009-03-27

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RU2005114008/14A RU2350323C2 (ru) 2002-10-11 2003-10-09 Способ кардиопротекции и нейропротекции внутривенным введением галогенсодержащего летучего анестезирующего средства

Country Status (19)

Country Link
US (1) US7999011B2 (https=)
EP (1) EP1558226B1 (https=)
JP (1) JP5210486B2 (https=)
KR (2) KR20120030598A (https=)
CN (2) CN1703209A (https=)
AT (1) ATE546136T1 (https=)
AU (1) AU2003282464B2 (https=)
BR (1) BR0314617A (https=)
CA (1) CA2500310C (https=)
DK (1) DK1558226T3 (https=)
ES (1) ES2382911T3 (https=)
HK (1) HK1079703A1 (https=)
IL (1) IL167472A (https=)
MX (1) MXPA05003741A (https=)
NZ (1) NZ539298A (https=)
PL (1) PL219493B1 (https=)
RU (1) RU2350323C2 (https=)
WO (1) WO2004032858A2 (https=)
ZA (1) ZA200502741B (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
CN101014364B (zh) 2002-12-24 2012-01-18 里纳特神经系统学公司 抗ngf抗体及其使用方法
ES2573253T3 (es) * 2006-09-20 2016-06-06 The Board Of Regents Of The University Of Texas System Métodos para el suministro de anestésicos volátiles para anestesia regional y/o alivio del dolor
GB0619499D0 (en) 2006-10-03 2006-11-08 Lucent Technologies Inc Encrypted data in a wireless telecommunications system
DE112008002914A5 (de) * 2007-11-06 2010-09-30 B. Braun Melsungen Ag Einen hydrophoben Wirkstoff enthaltende wässrige Emulsionen
EP2244783B1 (en) * 2008-01-22 2019-12-18 Board Of Regents, The University Of Texas System Volatile anesthetic compositions and methods of use
EP3581169A1 (en) * 2008-01-22 2019-12-18 The Board Of Regents Of The University Of Texas System Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief
AU2015200210B2 (en) * 2008-01-22 2016-08-11 The Board Of Regents Of The University Of Texas System Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief
EP2427243A4 (en) * 2009-05-05 2012-11-21 Vapogenix Inc NEW FORMULATIONS OF VOLATILE ANESTHETICS AND METHOD OF ADMINISTRATION
RU2408396C1 (ru) * 2009-07-30 2011-01-10 Государственное образовательное учреждение высшего профессионального образования "Тверская государственная медицинская академия Федерального агентства по здравоохранению и федеральному развитию" Комбинированная двухсегментарная регионарная анестезия при выполнении каротидной эндартерэктомии у больных критической ишемией нижних конечностей и выраженным болевым синдромом
US20120219596A1 (en) 2009-07-30 2012-08-30 Wendelin Stark Injectable formulation for treatment and protection of patients having an inflammatory reaction or an ischemia-reperfusion event
FR2956323B1 (fr) * 2010-02-15 2013-12-20 Air Liquide Medicament gazeux inhalable a base d'argon contre les deficiences ou defaillances d'organes peripheriques
US9968540B2 (en) * 2011-06-24 2018-05-15 Vapogenix, Inc. Formulations and methods for treating dermatological disorders or diseases
AU2014227996B2 (en) 2013-03-15 2018-08-23 Vapogenix, Inc. Novel analgesic compositions
ITMO20130075A1 (it) 2013-03-22 2014-09-23 Enrico Giuliani Dispositivo di somministrazione

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1018773A (en) * 1962-09-13 1966-02-02 Bellon Labor Sa Roger ª‡-phenyl-ª‰-2-furyl-propionitrile derivatives
US5885984A (en) * 1993-09-24 1999-03-23 University Of British Columbia Aminocyclohexylesters and uses thereof
RU2159227C2 (ru) * 1994-10-26 2000-11-20 Смитклайн Бичам Лаборатуар Фармасетик Нитробензамиды, фармацевтическая композиция, способ ее получения и способ лечения и/или профилактики аритмий и ишемических нарушений ритма

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073943A (en) 1974-09-11 1978-02-14 Apoteksvarucentralen Vitrum Ab Method of enhancing the administration of pharmalogically active agents
US5628930A (en) 1992-10-27 1997-05-13 Alliance Pharmaceutical Corp. Stabilization of fluorocarbon emulsions
US5635538A (en) 1993-03-16 1997-06-03 Alliance Pharmaceutical Corp. Fluorocarbon emulsions with reduced pulmonary gas-trapping properties
JP2961034B2 (ja) * 1993-09-16 1999-10-12 アルプス電気株式会社 磁気ヘッド
GB2350297A (en) * 1999-05-27 2000-11-29 Abbott Lab Injectable halogenated anesthetic formulation in emulsion form
WO2002007729A1 (en) 2000-07-26 2002-01-31 Taro Pharmaceutical Industries Ltd. Non-sedating barbiturate compounds as neuroprotective agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1018773A (en) * 1962-09-13 1966-02-02 Bellon Labor Sa Roger ª‡-phenyl-ª‰-2-furyl-propionitrile derivatives
US5885984A (en) * 1993-09-24 1999-03-23 University Of British Columbia Aminocyclohexylesters and uses thereof
RU2159227C2 (ru) * 1994-10-26 2000-11-20 Смитклайн Бичам Лаборатуар Фармасетик Нитробензамиды, фармацевтическая композиция, способ ее получения и способ лечения и/или профилактики аритмий и ишемических нарушений ритма

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ЛЕБЕДИНСКИЙ К.М. Анестезия и системная гемодинамика. Оценка и коррекция системной гемодинамики во время операции и анестезии. СПб., 2000, полнотекстовый фрагмент. *
описание. *
реферат. Руководство по анестезиологии // Под ред. А.Р. ЭЙТКЕНХЕДА и др. - М.: Медицина, 1999, с.168-171. PIRIOU V. et al., Pharmacological preconditioning: comparison of desflurane, sevoflurane, isoflurane and halothane in rabbit myocardium., Br J Anaesth. 2002 Sep; 89(3): 486-91, реферат. LOUVIER N. et al., Do halogenated anesthetics protect from ischemic and reperfusion myocardial injuries?, Ann Fr Anesth Reanim. 1994; 13(5): 690-8, реферат. *

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DK1558226T3 (da) 2012-05-07
WO2004032858A3 (en) 2004-09-23
KR101403264B1 (ko) 2014-06-02
WO2004032858A2 (en) 2004-04-22
CA2500310A1 (en) 2004-04-22
RU2005114008A (ru) 2005-10-27
AU2003282464A1 (en) 2004-05-04
EP1558226A2 (en) 2005-08-03
PL376217A1 (en) 2005-12-27
NZ539298A (en) 2008-11-28
EP1558226A4 (en) 2008-04-02
ES2382911T3 (es) 2012-06-14
AU2003282464B2 (en) 2010-02-25
IL167472A (en) 2013-10-31
MXPA05003741A (es) 2005-06-17
US20040127578A1 (en) 2004-07-01
JP2006504740A (ja) 2006-02-09
KR20050056230A (ko) 2005-06-14
JP5210486B2 (ja) 2013-06-12
BR0314617A (pt) 2005-08-02
HK1079703A1 (zh) 2006-04-13
CN102283821A (zh) 2011-12-21
KR20120030598A (ko) 2012-03-28
CA2500310C (en) 2013-03-12
EP1558226B1 (en) 2012-02-22
US7999011B2 (en) 2011-08-16
ATE546136T1 (de) 2012-03-15
CN1703209A (zh) 2005-11-30
PL219493B1 (pl) 2015-05-29
ZA200502741B (en) 2006-02-22

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Effective date: 20181010