RU2328287C2 - Схема приема erbb2 противоопухолевых агентов - Google Patents

Схема приема erbb2 противоопухолевых агентов Download PDF

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Publication number
RU2328287C2
RU2328287C2 RU2006102125/14A RU2006102125A RU2328287C2 RU 2328287 C2 RU2328287 C2 RU 2328287C2 RU 2006102125/14 A RU2006102125/14 A RU 2006102125/14A RU 2006102125 A RU2006102125 A RU 2006102125A RU 2328287 C2 RU2328287 C2 RU 2328287C2
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Russia
Prior art keywords
inhibitor
erbb2
methyl
test compound
bid
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RU2006102125/14A
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English (en)
Russian (ru)
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RU2006102125A (ru
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Самит Кумар БХАТТАЧАРИА (US)
Самит Кумар Бхаттачариа
Ричард Деймиан КОННЕЛЛ (US)
Ричард Деймиан КОННЕЛЛ
Джеймс Дейл МОЙЕР (US)
Джеймс Дейл МОЙЕР
Джитеш Пранлал ДЖАНИ (US)
Джитеш Пранлал ДЖАНИ
Деннис Алан НОЕ (US)
Деннис Алан НОЕ
Стефанус Иоганнес СТЕЙН (US)
Стефанус Иоганнес СТЕЙН
Original Assignee
Пфайзер Продактс Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2006102125/14A 2003-08-18 2004-08-06 Схема приема erbb2 противоопухолевых агентов RU2328287C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49591903P 2003-08-18 2003-08-18
US60/495,919 2003-08-18

Publications (2)

Publication Number Publication Date
RU2006102125A RU2006102125A (ru) 2007-09-27
RU2328287C2 true RU2328287C2 (ru) 2008-07-10

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RU2006102125/14A RU2328287C2 (ru) 2003-08-18 2004-08-06 Схема приема erbb2 противоопухолевых агентов

Country Status (18)

Country Link
US (1) US20050119288A1 (OSRAM)
EP (1) EP1658080A1 (OSRAM)
JP (1) JP2007502807A (OSRAM)
KR (2) KR20060037447A (OSRAM)
CN (1) CN1838959A (OSRAM)
AR (1) AR045268A1 (OSRAM)
AU (1) AU2004264726A1 (OSRAM)
BR (1) BRPI0413745A (OSRAM)
CA (1) CA2536140A1 (OSRAM)
CO (1) CO5670356A2 (OSRAM)
IL (1) IL173127A0 (OSRAM)
MX (1) MXPA06001989A (OSRAM)
NO (1) NO20061252L (OSRAM)
RU (1) RU2328287C2 (OSRAM)
SG (1) SG135193A1 (OSRAM)
TW (1) TW200522966A (OSRAM)
WO (1) WO2005016347A1 (OSRAM)
ZA (1) ZA200600517B (OSRAM)

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AU2003210787B2 (en) 2002-02-01 2009-04-23 Medinol Ltd. Phosphorus-containing compounds & uses thereof
TWI229650B (en) * 2002-11-19 2005-03-21 Sharp Kk Substrate accommodating tray
US7501427B2 (en) 2003-08-14 2009-03-10 Array Biopharma, Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
EP1660090B1 (en) * 2003-08-14 2012-11-21 Array Biopharma, Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
JP4036885B2 (ja) 2003-09-19 2008-01-23 アストラゼネカ アクチボラグ キナゾリン誘導体
ME01267B (me) 2004-05-06 2013-06-20 Warner Lambert Co 4-fenilaminokinazolin-6-ilamidi
GB0427131D0 (en) * 2004-12-10 2005-01-12 Glaxosmithkline Biolog Sa Novel combination
EP1896030A1 (en) * 2005-06-03 2008-03-12 Pfizer Products Incorporated Combinations of erbb2 inhibitors with other therapeutic agents in the treatment of cancer
AU2006259261B2 (en) * 2005-06-16 2013-06-13 Myrexis, Inc. Pharmaceutical compositions and use thereof
WO2007014335A2 (en) * 2005-07-27 2007-02-01 The University Of Texas System Combinations comprising gemcitabine and tyrosine kinase inhibitors for the treatment of pancreatic cancer
US8945573B2 (en) 2005-09-08 2015-02-03 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Targeted identification of immunogenic peptides
EP2662082A1 (en) * 2005-11-14 2013-11-13 Ariad Pharmaceuticals, Incorporated Administration of mTOR inhibitors
PL2090575T3 (pl) 2005-11-15 2011-09-30 Array Biopharma Inc Sposoby i związki pośrednie do otrzymywania pochodnych N4-fenylo-chinazolino-4-aminy
CA2647671A1 (en) * 2006-03-31 2007-11-01 Massachusetts Institute Of Technology Treatment of tumors expressing mutant egf receptors
US20090099103A1 (en) * 2006-04-05 2009-04-16 Novartis Ag. Combinations of therapeutic agents for treating cancer
EP2094241A4 (en) 2006-11-14 2013-04-17 Ariad Pharma Inc ORAL FORMULATIONS
WO2008124826A1 (en) * 2007-04-10 2008-10-16 Myriad Genetics, Inc. Methods for treating cancer
WO2008124823A1 (en) * 2007-04-10 2008-10-16 Myriad Genetics, Inc. Method of treating melanoma
WO2008124828A1 (en) * 2007-04-10 2008-10-16 Myriad Genetics, Inc. Methods for treating vascular disruption disorders
CN101742910A (zh) * 2007-04-10 2010-06-16 美瑞德制药公司 治疗脑癌的方法
AU2008236995A1 (en) * 2007-04-10 2008-10-16 Myrexis, Inc. Dosages and methods for the treatment of cancer
US9551033B2 (en) 2007-06-08 2017-01-24 Genentech, Inc. Gene expression markers of tumor resistance to HER2 inhibitor treatment
ES2417148T3 (es) 2007-06-08 2013-08-06 Genentech, Inc. Marcadores de expresión génica de la resistencia tumoral al tratamiento con inhibidor de HER2
US8252805B2 (en) * 2008-05-07 2012-08-28 Teva Pharmaceutical Industries Ltd. Forms of lapatinib ditosylate and processes for preparation thereof
US20100087459A1 (en) * 2008-08-26 2010-04-08 Leonid Metsger Forms of lapatinib compounds and processes for the preparation thereof
CN102356092B (zh) * 2009-03-20 2014-11-05 霍夫曼-拉罗奇有限公司 双特异性抗-her抗体
JP6130391B2 (ja) 2011-11-23 2017-05-17 インテリカイン， エルエルシー Ｍｔｏｒ阻害剤を使用する強化された治療レジメン
CN110564604B (zh) 2014-01-31 2023-09-29 凸版印刷株式会社 液滴的形成方法、生物分子分析方法及生物分子分析试剂盒
WO2017075495A1 (en) * 2015-10-28 2017-05-04 Tarveda Therapeutics, Inc. Sstr-targeted conjugates and particles and formulations thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2130780C1 (ru) * 1992-04-10 1999-05-27 Рисерч Дивелопмент Фаундейшн Композиция и способ обработки неопластической клетки
RU2174977C2 (ru) * 1995-03-30 2001-10-20 Пфайзер Инк. Производные 4-(замещенного фениламино)хиназолина или их фармацевтически приемлемые соли, способ ингибирования рецепторной тирозинкиназы и фармацевтическая композиция
RU2198879C2 (ru) * 1996-09-25 2003-02-20 Зенека Лимитед Производные хиназолина, способы их получения, содержащие их фармацевтические композиции, способ достижения антиангиогенного и/или эффекта снижения проницаемости кровеносных сосудов у теплокровного животного
WO2003050108A1 (en) * 2001-12-12 2003-06-19 Pfizer Products Inc. Salt forms of e-2-methoxy-n-(3-(4-(3-methyl-pyridin-3-yloxy)-phenylamino)-quinazolin-6-yl)-allyl)-acetamide, its preparation and its use against cancer

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WO2001098277A2 (en) * 2000-06-22 2001-12-27 Pfizer Products Inc. Substituted bicyclic derivatives for the treatment of abnormal cell growth
BR0214499A (pt) * 2001-12-12 2005-05-10 Pfizer Prod Inc Derivados de quinazolina para o tratamento do crescimento anormal das células
JP4611745B2 (ja) * 2002-11-20 2011-01-12 アレイ バイオファーマ、インコーポレイテッド ＥｒｂＢ２及びＥＧＦＲ阻害剤としてのシアノグアニジン及びシアノアミジン
EP1575592A1 (en) * 2002-12-18 2005-09-21 Pfizer Products Inc. 4-anilino quinazoline derivatives for the treatment of abnormal cell growth

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
RU2130780C1 (ru) * 1992-04-10 1999-05-27 Рисерч Дивелопмент Фаундейшн Композиция и способ обработки неопластической клетки
RU2174977C2 (ru) * 1995-03-30 2001-10-20 Пфайзер Инк. Производные 4-(замещенного фениламино)хиназолина или их фармацевтически приемлемые соли, способ ингибирования рецепторной тирозинкиназы и фармацевтическая композиция
RU2198879C2 (ru) * 1996-09-25 2003-02-20 Зенека Лимитед Производные хиназолина, способы их получения, содержащие их фармацевтические композиции, способ достижения антиангиогенного и/или эффекта снижения проницаемости кровеносных сосудов у теплокровного животного
WO2003050108A1 (en) * 2001-12-12 2003-06-19 Pfizer Products Inc. Salt forms of e-2-methoxy-n-(3-(4-(3-methyl-pyridin-3-yloxy)-phenylamino)-quinazolin-6-yl)-allyl)-acetamide, its preparation and its use against cancer

Non-Patent Citations (2)

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Title
весь документ, см. с.7, 8, 10. Беликов В.Г. Фармацевтическая химия т.1. - М.: Высшая школа, 1993, с.43-47. *
формула. *

Also Published As

Publication number Publication date
CA2536140A1 (en) 2005-02-24
CO5670356A2 (es) 2006-08-31
RU2006102125A (ru) 2007-09-27
AU2004264726A1 (en) 2005-02-24
WO2005016347A1 (en) 2005-02-24
NO20061252L (no) 2006-05-16
AR045268A1 (es) 2005-10-19
KR20080014144A (ko) 2008-02-13
MXPA06001989A (es) 2006-05-17
TW200522966A (en) 2005-07-16
US20050119288A1 (en) 2005-06-02
ZA200600517B (en) 2007-02-28
IL173127A0 (en) 2006-06-11
EP1658080A1 (en) 2006-05-24
BRPI0413745A (pt) 2006-10-24
JP2007502807A (ja) 2007-02-15
SG135193A1 (en) 2007-09-28
KR20060037447A (ko) 2006-05-03
CN1838959A (zh) 2006-09-27

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Effective date: 20090807