BRPI0413745A - horário mde dosagem para agentes anticancerìgenos erbb2 - Google Patents
horário mde dosagem para agentes anticancerìgenos erbb2Info
- Publication number
- BRPI0413745A BRPI0413745A BRPI0413745-0A BRPI0413745A BRPI0413745A BR PI0413745 A BRPI0413745 A BR PI0413745A BR PI0413745 A BRPI0413745 A BR PI0413745A BR PI0413745 A BRPI0413745 A BR PI0413745A
- Authority
- BR
- Brazil
- Prior art keywords
- erbb2
- mammal
- relates
- anticancer agents
- dosing schedule
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 4
- 239000003112 inhibitor Substances 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 241000124008 Mammalia Species 0.000 abstract 3
- 101710100968 Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 3
- 230000002018 overexpression Effects 0.000 abstract 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000001802 infusion Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"HORáRIO DE DOSAGEM PARA AGENTES ANTICANCERìGENOS ERBB2". A presente invenção refere-se a métodos para um método para o tratamento da sobreexpressão do erbB2 em um mamífero com necessidade de tal tratamento através da administração ao mamífero de uma quantidade terapeuticamente eficaz de um primeiro inibidor de um receptor de erbB2 e depois, após um intervalo de menos do que 24 horas, administração ao mamífero dentre uma a seis quantidades terapeuticamente eficazes do O mesmo ou de um diferente inibidor do receptor de erbB2. A invenção também refere-se a uma infusão diária lenta do inibidor de erbB2. A sobreexpressão do receptor de erbB2 pode resultar em um crescimento celular anormal e levar ao câncer. Através dos métodos da invenção, a eficácia e segurança dos inibidores é melhorada. A invenção também refere-se a kits para facilitar o método de administração das dosagens da invenção.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49591903P | 2003-08-18 | 2003-08-18 | |
PCT/IB2004/002580 WO2005016347A1 (en) | 2003-08-18 | 2004-08-06 | Dosing schedule for erbb2 anticancer agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0413745A true BRPI0413745A (pt) | 2006-10-24 |
Family
ID=34193358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0413745-0A BRPI0413745A (pt) | 2003-08-18 | 2004-08-06 | horário mde dosagem para agentes anticancerìgenos erbb2 |
Country Status (18)
Country | Link |
---|---|
US (1) | US20050119288A1 (pt) |
EP (1) | EP1658080A1 (pt) |
JP (1) | JP2007502807A (pt) |
KR (2) | KR20060037447A (pt) |
CN (1) | CN1838959A (pt) |
AR (1) | AR045268A1 (pt) |
AU (1) | AU2004264726A1 (pt) |
BR (1) | BRPI0413745A (pt) |
CA (1) | CA2536140A1 (pt) |
CO (1) | CO5670356A2 (pt) |
IL (1) | IL173127A0 (pt) |
MX (1) | MXPA06001989A (pt) |
NO (1) | NO20061252L (pt) |
RU (1) | RU2328287C2 (pt) |
SG (1) | SG135193A1 (pt) |
TW (1) | TW200522966A (pt) |
WO (1) | WO2005016347A1 (pt) |
ZA (1) | ZA200600517B (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101004224B1 (ko) | 2002-02-01 | 2010-12-27 | 어리어드 파마슈티칼스, 인코포레이티드 | 인 함유 화합물 및 이의 용도 |
TWI229650B (en) * | 2002-11-19 | 2005-03-21 | Sharp Kk | Substrate accommodating tray |
US7501427B2 (en) | 2003-08-14 | 2009-03-10 | Array Biopharma, Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
ES2399427T3 (es) | 2003-08-14 | 2013-04-01 | Array Biopharma, Inc. | Análogos de quinazolina como inhibidores de los receptores de la tirosina-quinasa |
US8318752B2 (en) | 2003-09-19 | 2012-11-27 | Astrazeneca Ab | 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoyl-methyl)piperidin-4-yl]oxy}quinazoline, its pharmaceutically acceptable salts, and pharmaceutical compositions comprising the same |
CA2565812C (en) | 2004-05-06 | 2012-03-13 | Warner-Lambert Company Llc | 4-phenylamino-quinazolin-6-yl-amides |
GB0427131D0 (en) * | 2004-12-10 | 2005-01-12 | Glaxosmithkline Biolog Sa | Novel combination |
JP2008542354A (ja) * | 2005-06-03 | 2008-11-27 | ファイザー・プロダクツ・インク | 癌治療におけるerbB2阻害剤と他の治療薬の併用 |
JP5235662B2 (ja) * | 2005-06-16 | 2013-07-10 | ミリアド ジェネティクス, インコーポレイテッド | 薬学的組成物およびその使用 |
JP2009502960A (ja) * | 2005-07-27 | 2009-01-29 | ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム | 膵臓癌の処置のためのゲムシタビンおよびチロシンキナーゼ阻害剤を含む組み合わせ |
US8945573B2 (en) * | 2005-09-08 | 2015-02-03 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Targeted identification of immunogenic peptides |
CA2629714A1 (en) * | 2005-11-14 | 2007-05-24 | Ariad Gene Therapeutics, Inc. | Administration of an mtor inhibitor to treat patients with cancer |
PT2090575E (pt) | 2005-11-15 | 2011-06-06 | Array Biopharma Inc | Inibidores de erbb |
EP2163563A1 (en) * | 2006-03-31 | 2010-03-17 | Massachusetts Institute of Technology | Treatment of tumors expressing mutant EGF receptors |
WO2007115286A2 (en) * | 2006-04-05 | 2007-10-11 | Novartis Ag. | Combinations of therapeutic agents for treating cancer |
JP2010509400A (ja) | 2006-11-14 | 2010-03-25 | アリアド・ファーマシューティカルズ・インコーポレイテッド | 経口処方組成物 |
CA2720989A1 (en) * | 2007-04-10 | 2008-10-16 | Myrexis, Inc. | Methods for treating cancer |
CN101742910A (zh) * | 2007-04-10 | 2010-06-16 | 美瑞德制药公司 | 治疗脑癌的方法 |
EP2144887A4 (en) * | 2007-04-10 | 2012-10-03 | Myrexis Inc | PHARMACEUTICAL FORMS AND METHOD FOR THE TREATMENT OF CANCER |
WO2008124823A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Method of treating melanoma |
WO2008124828A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Methods for treating vascular disruption disorders |
CA3006428A1 (en) | 2007-06-08 | 2008-12-18 | Genentech, Inc. | Gene expression markers of tumor resistance to her2 inhibitor treatment |
US9551033B2 (en) | 2007-06-08 | 2017-01-24 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
US8252805B2 (en) * | 2008-05-07 | 2012-08-28 | Teva Pharmaceutical Industries Ltd. | Forms of lapatinib ditosylate and processes for preparation thereof |
WO2010027848A2 (en) * | 2008-08-26 | 2010-03-11 | Teva Pharmaceutical Industries Ltd. | Forms of lapatinib compounds and processes for the preparation thereof |
KR20130080871A (ko) | 2009-03-20 | 2013-07-15 | 제넨테크, 인크. | 이중특이적 항-her 항체 |
EP2793893A4 (en) | 2011-11-23 | 2015-07-08 | Intellikine Llc | IMPROVED TREATMENT REGIMES USING MTOR INHIBITORS |
JP6183471B2 (ja) * | 2014-01-31 | 2017-08-23 | 凸版印刷株式会社 | 生体分子解析キット及び生体分子解析方法 |
EP3368546A4 (en) | 2015-10-28 | 2019-06-26 | Tarveda Therapeutics, Inc. | SSTR TARGETED CONJUGATES, AND ITS PARTICLES AND FORMULATIONS |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA02012870A (es) * | 2000-06-22 | 2003-05-14 | Pfizer Prod Inc | Derivados biciclicos sustituidos para el tratamiento del crecimiento celular anormal. |
OA12734A (en) * | 2001-12-12 | 2006-06-28 | Pfizer Prod Inc | Quinazoline derivatives for the treatment of abnormal cell growth. |
RS46404A (en) * | 2001-12-12 | 2006-10-27 | Pfizer Products Inc. | Salt forms of e-2-methoxy-n-(3-(4-(3-methyul-pyridin-3- yloxy)-phenylamino)-quinazolin-6-yl)-allyl)-acetamide,its preparation and its use against cancer |
CA2506503A1 (en) * | 2002-11-20 | 2004-06-03 | Array Biopharma, Inc. | Cyanoguanidines and cyanoamidines as erbb2 and egfr inhibitors |
RU2005119172A (ru) * | 2002-12-18 | 2006-01-20 | Пфайзер Продактс Инк. (Us) | Производные 4-анилинхиназолина для лечения патологического роста клеток |
-
2004
- 2004-08-06 RU RU2006102125/14A patent/RU2328287C2/ru not_active IP Right Cessation
- 2004-08-06 WO PCT/IB2004/002580 patent/WO2005016347A1/en active Application Filing
- 2004-08-06 BR BRPI0413745-0A patent/BRPI0413745A/pt not_active IP Right Cessation
- 2004-08-06 KR KR1020067003190A patent/KR20060037447A/ko not_active Application Discontinuation
- 2004-08-06 EP EP04744217A patent/EP1658080A1/en not_active Withdrawn
- 2004-08-06 SG SG200706063-5A patent/SG135193A1/en unknown
- 2004-08-06 CA CA002536140A patent/CA2536140A1/en not_active Abandoned
- 2004-08-06 JP JP2006523695A patent/JP2007502807A/ja not_active Withdrawn
- 2004-08-06 KR KR1020087000092A patent/KR20080014144A/ko not_active Application Discontinuation
- 2004-08-06 MX MXPA06001989A patent/MXPA06001989A/es not_active Application Discontinuation
- 2004-08-06 AU AU2004264726A patent/AU2004264726A1/en not_active Abandoned
- 2004-08-06 CN CNA200480023705XA patent/CN1838959A/zh active Pending
- 2004-08-17 TW TW093124706A patent/TW200522966A/zh unknown
- 2004-08-17 US US10/919,831 patent/US20050119288A1/en not_active Abandoned
- 2004-08-17 AR ARP040102941A patent/AR045268A1/es not_active Application Discontinuation
-
2006
- 2006-01-12 IL IL173127A patent/IL173127A0/en unknown
- 2006-01-18 ZA ZA200600517A patent/ZA200600517B/xx unknown
- 2006-02-15 CO CO06015089A patent/CO5670356A2/es not_active Application Discontinuation
- 2006-03-17 NO NO20061252A patent/NO20061252L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA06001989A (es) | 2006-05-17 |
CN1838959A (zh) | 2006-09-27 |
WO2005016347A1 (en) | 2005-02-24 |
NO20061252L (no) | 2006-05-16 |
CO5670356A2 (es) | 2006-08-31 |
AR045268A1 (es) | 2005-10-19 |
TW200522966A (en) | 2005-07-16 |
KR20060037447A (ko) | 2006-05-03 |
KR20080014144A (ko) | 2008-02-13 |
SG135193A1 (en) | 2007-09-28 |
CA2536140A1 (en) | 2005-02-24 |
JP2007502807A (ja) | 2007-02-15 |
IL173127A0 (en) | 2006-06-11 |
US20050119288A1 (en) | 2005-06-02 |
RU2328287C2 (ru) | 2008-07-10 |
AU2004264726A1 (en) | 2005-02-24 |
EP1658080A1 (en) | 2006-05-24 |
RU2006102125A (ru) | 2007-09-27 |
ZA200600517B (en) | 2007-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |