RU2320321C2 - Композиции депо кратковременного действия - Google Patents
Композиции депо кратковременного действия Download PDFInfo
- Publication number
- RU2320321C2 RU2320321C2 RU2005101640A RU2005101640A RU2320321C2 RU 2320321 C2 RU2320321 C2 RU 2320321C2 RU 2005101640 A RU2005101640 A RU 2005101640A RU 2005101640 A RU2005101640 A RU 2005101640A RU 2320321 C2 RU2320321 C2 RU 2320321C2
- Authority
- RU
- Russia
- Prior art keywords
- composition according
- injectable depot
- depot composition
- aromatic
- polymer
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 43
- 239000003814 drug Substances 0.000 claims abstract 23
- 229920000642 polymer Polymers 0.000 claims abstract 14
- -1 aromatic alcohols Chemical class 0.000 claims abstract 12
- 239000002904 solvent Substances 0.000 claims abstract 11
- 229940079593 drug Drugs 0.000 claims abstract 6
- 229920000249 biocompatible polymer Polymers 0.000 claims abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 4
- 150000008365 aromatic ketones Chemical class 0.000 claims abstract 3
- 229940124597 therapeutic agent Drugs 0.000 claims 16
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 13
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical group CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 6
- 229920000388 Polyphosphate Polymers 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 239000001205 polyphosphate Substances 0.000 claims 5
- 235000011176 polyphosphates Nutrition 0.000 claims 5
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical group C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 239000004310 lactic acid Substances 0.000 claims 3
- 235000014655 lactic acid Nutrition 0.000 claims 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 229940035676 analgesics Drugs 0.000 claims 2
- 239000000730 antalgic agent Substances 0.000 claims 2
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 2
- 239000000164 antipsychotic agent Substances 0.000 claims 2
- 235000019445 benzyl alcohol Nutrition 0.000 claims 2
- 229960002903 benzyl benzoate Drugs 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- HBGGXOJOCNVPFY-UHFFFAOYSA-N diisononyl phthalate Chemical compound CC(C)CCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCC(C)C HBGGXOJOCNVPFY-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N ethyl benzoate Chemical group CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 239000003589 local anesthetic agent Substances 0.000 claims 2
- 229960005015 local anesthetics Drugs 0.000 claims 2
- 239000002207 metabolite Substances 0.000 claims 2
- 239000003607 modifier Substances 0.000 claims 2
- 230000003204 osmotic effect Effects 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
- 229920002101 Chitin Polymers 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000004895 Lipoproteins Human genes 0.000 claims 1
- 108090001030 Lipoproteins Proteins 0.000 claims 1
- 102000011931 Nucleoproteins Human genes 0.000 claims 1
- 108010061100 Nucleoproteins Proteins 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 230000002491 angiogenic effect Effects 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 239000003080 antimitotic agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 239000003527 fibrinolytic agent Substances 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229920001308 poly(aminoacid) Polymers 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 239000000622 polydioxanone Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920001855 polyketal Polymers 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 229920006324 polyoxymethylene Polymers 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 229920001897 terpolymer Polymers 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 159000000032 aromatic acids Chemical class 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B18/00—Use of agglomerated or waste materials or refuse as fillers for mortars, concrete or artificial stone; Treatment of agglomerated or waste materials or refuse, specially adapted to enhance their filling properties in mortars, concrete or artificial stone
- C04B18/04—Waste materials; Refuse
- C04B18/18—Waste materials; Refuse organic
- C04B18/20—Waste materials; Refuse organic from macromolecular compounds
- C04B18/22—Rubber, e.g. ground waste tires
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/02—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing hydraulic cements other than calcium sulfates
- C04B28/04—Portland cements
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/40—Porous or lightweight materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W30/00—Technologies for solid waste management
- Y02W30/50—Reuse, recycling or recovery technologies
- Y02W30/91—Use of waste materials as fillers for mortars or concrete
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Ceramic Engineering (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Structural Engineering (AREA)
- Materials Engineering (AREA)
- Neurosurgery (AREA)
- Environmental & Geological Engineering (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Civil Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39186702P | 2002-06-25 | 2002-06-25 | |
| US60/391,867 | 2002-06-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005101640A RU2005101640A (ru) | 2005-08-10 |
| RU2320321C2 true RU2320321C2 (ru) | 2008-03-27 |
Family
ID=30000765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005101640A RU2320321C2 (ru) | 2002-06-25 | 2003-06-25 | Композиции депо кратковременного действия |
Country Status (20)
| Country | Link |
|---|---|
| EP (3) | EP2311431A1 (enExample) |
| JP (2) | JP2005533081A (enExample) |
| KR (1) | KR101172721B1 (enExample) |
| CN (1) | CN1671357B (enExample) |
| AR (1) | AR039729A1 (enExample) |
| AU (1) | AU2003245643B2 (enExample) |
| BR (1) | BR0312033A (enExample) |
| CA (1) | CA2492047C (enExample) |
| EC (1) | ECSP055566A (enExample) |
| ES (1) | ES2530874T3 (enExample) |
| IL (1) | IL165865A0 (enExample) |
| MA (1) | MA27371A1 (enExample) |
| MX (1) | MXPA05000199A (enExample) |
| NO (1) | NO20050366L (enExample) |
| NZ (1) | NZ574443A (enExample) |
| PL (1) | PL207147B1 (enExample) |
| RU (1) | RU2320321C2 (enExample) |
| TW (1) | TWI353854B (enExample) |
| WO (1) | WO2004000269A1 (enExample) |
| ZA (1) | ZA200500677B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| BR0315304A (pt) | 2002-11-06 | 2005-08-16 | Alza Corp | Formulações com depósito para liberação controlada |
| US20050106214A1 (en) * | 2003-11-14 | 2005-05-19 | Guohua Chen | Excipients in drug delivery vehicles |
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| US8658210B2 (en) | 2006-04-17 | 2014-02-25 | Advanced Cardiovascular Systems, Inc. | Polyesteramide platform for site specific drug delivery |
| JP5599705B2 (ja) | 2007-05-18 | 2014-10-01 | デュレクト コーポレーション | 改良されたデポー製剤 |
| CA2687979C (en) | 2007-05-25 | 2017-07-04 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of risperidone compounds |
| US8846068B2 (en) * | 2008-04-18 | 2014-09-30 | Warsaw Orthopedic, Inc. | Methods and compositions for treating post-operative pain comprising a local anesthetic |
| RS60051B1 (sr) * | 2011-06-10 | 2020-04-30 | Ramscor Inc | Formulacije sa produženim oslobađanjem za isporuku proteina u oko i postupci njihove pripreme |
| US20140308352A1 (en) | 2013-03-11 | 2014-10-16 | Zogenix Inc. | Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material |
| CN109602692B (zh) | 2013-03-11 | 2022-11-04 | 度瑞公司 | 包含高粘度液体载体的可注射控制释放组合物 |
| CN105764491A (zh) | 2013-12-09 | 2016-07-13 | 度瑞公司 | 药物活性剂复合物、聚合物复合物,以及包括其的组合物和方法 |
| KR20220140711A (ko) | 2020-01-13 | 2022-10-18 | 듀렉트 코퍼레이션 | 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법 |
| CN111388406B (zh) * | 2020-03-24 | 2024-02-23 | 西安力邦医药科技有限责任公司 | 氟维司群或其衍生物可注射递药贮库及其制备方法和应用 |
| KR20230145053A (ko) | 2021-01-12 | 2023-10-17 | 듀렉트 코퍼레이션 | 지속 방출 약물 전달 시스템 및 관련 방법 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2127586C1 (ru) * | 1991-12-27 | 1999-03-20 | Мерк Энд Ко., Инк. | Устройство доставки лекарственного препарата, способ получения устройства |
| WO2000074650A2 (en) * | 1999-06-04 | 2000-12-14 | Alza Corporation | Implantable gel compositions and method of manufacture |
| WO2002000137A1 (en) * | 2000-06-28 | 2002-01-03 | Shukla Atul J | Biodegradable vehicles and delivery systems of biologically active substances |
| WO2002038185A2 (en) * | 2000-11-13 | 2002-05-16 | Atrix Laboratories, Inc. | Injectable sustained release delivery system with loperamide |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3797492A (en) | 1972-12-27 | 1974-03-19 | Alza Corp | Device for dispensing product with directional guidance member |
| US3987790A (en) | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4443340A (en) | 1981-10-09 | 1984-04-17 | Betz Laboratories, Inc. | Control of iron induced fouling in water systems |
| US4985404A (en) | 1984-10-04 | 1991-01-15 | Monsanto Company | Prolonged release of biologically active polypeptides |
| US4865845A (en) | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
| US4853218A (en) | 1987-02-24 | 1989-08-01 | Schering Corporation | Zinc-protamine-alpha interferon complex |
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
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| US5112614A (en) | 1989-09-14 | 1992-05-12 | Alza Corporation | Implantable delivery dispenser |
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| US5151093A (en) | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
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| GB9027422D0 (en) | 1990-12-18 | 1991-02-06 | Scras | Osmotically driven infusion device |
| US5137727A (en) | 1991-06-12 | 1992-08-11 | Alza Corporation | Delivery device providing beneficial agent stability |
| US5288214A (en) | 1991-09-30 | 1994-02-22 | Toshio Fukuda | Micropump |
| KR970007322B1 (ko) | 1991-12-19 | 1997-05-07 | 미쓰이도오아쓰 가가쿠 가부시키가이샤 | 폴리히드록시 카르복실산 및 그 제조방법 |
| US5456679A (en) | 1992-02-18 | 1995-10-10 | Alza Corporation | Delivery devices with pulsatile effect |
| US5308348A (en) | 1992-02-18 | 1994-05-03 | Alza Corporation | Delivery devices with pulsatile effect |
| US5209746A (en) | 1992-02-18 | 1993-05-11 | Alza Corporation | Osmotically driven delivery devices with pulsatile effect |
| US5656297A (en) | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
| GB9211268D0 (en) * | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
| US5242910A (en) | 1992-10-13 | 1993-09-07 | The Procter & Gamble Company | Sustained release compositions for treating periodontal disease |
| ES2151541T3 (es) | 1992-12-02 | 2001-01-01 | Alkermes Inc | Microesferas que contienen hormona del crecimiento de liberacion prolongada. |
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| AU739469B2 (en) * | 1996-12-20 | 2001-10-11 | Alza Corporation | Gel composition and methods |
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| US8883856B2 (en) * | 2000-02-28 | 2014-11-11 | John Jackson | Compositions and methods for the treatment of inflammatory diseases using topoisomerase inhibitors |
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| KR20040058100A (ko) | 2001-11-14 | 2004-07-03 | 알자 코포레이션 | 주입가능한 데포 조성물 및 그의 용도 |
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2003
- 2003-06-24 AR ARP030102261 patent/AR039729A1/es not_active Application Discontinuation
- 2003-06-24 TW TW92117159A patent/TWI353854B/zh not_active IP Right Cessation
- 2003-06-25 EP EP20100013179 patent/EP2311431A1/en not_active Withdrawn
- 2003-06-25 AU AU2003245643A patent/AU2003245643B2/en not_active Ceased
- 2003-06-25 BR BR0312033A patent/BR0312033A/pt not_active Application Discontinuation
- 2003-06-25 RU RU2005101640A patent/RU2320321C2/ru not_active IP Right Cessation
- 2003-06-25 IL IL16586503A patent/IL165865A0/xx unknown
- 2003-06-25 MX MXPA05000199A patent/MXPA05000199A/es active IP Right Grant
- 2003-06-25 ES ES03739271T patent/ES2530874T3/es not_active Expired - Lifetime
- 2003-06-25 EP EP20030739271 patent/EP1515697B1/en not_active Expired - Lifetime
- 2003-06-25 CN CN038176122A patent/CN1671357B/zh not_active Expired - Fee Related
- 2003-06-25 WO PCT/US2003/019762 patent/WO2004000269A1/en not_active Ceased
- 2003-06-25 PL PL373123A patent/PL207147B1/pl unknown
- 2003-06-25 NZ NZ574443A patent/NZ574443A/en not_active IP Right Cessation
- 2003-06-25 KR KR20047021001A patent/KR101172721B1/ko not_active Expired - Fee Related
- 2003-06-25 JP JP2004516150A patent/JP2005533081A/ja not_active Withdrawn
- 2003-06-25 CA CA2492047A patent/CA2492047C/en not_active Expired - Fee Related
- 2003-06-25 EP EP20100013092 patent/EP2316421A1/en not_active Withdrawn
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2005
- 2005-01-24 ZA ZA200500677A patent/ZA200500677B/xx unknown
- 2005-01-24 MA MA28060A patent/MA27371A1/fr unknown
- 2005-01-24 NO NO20050366A patent/NO20050366L/no not_active Application Discontinuation
- 2005-01-24 EC ECSP055566 patent/ECSP055566A/es unknown
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2010
- 2010-12-03 JP JP2010270394A patent/JP5631708B2/ja not_active Expired - Fee Related
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| RU2127586C1 (ru) * | 1991-12-27 | 1999-03-20 | Мерк Энд Ко., Инк. | Устройство доставки лекарственного препарата, способ получения устройства |
| WO2000074650A2 (en) * | 1999-06-04 | 2000-12-14 | Alza Corporation | Implantable gel compositions and method of manufacture |
| WO2002000137A1 (en) * | 2000-06-28 | 2002-01-03 | Shukla Atul J | Biodegradable vehicles and delivery systems of biologically active substances |
| WO2002038185A2 (en) * | 2000-11-13 | 2002-05-16 | Atrix Laboratories, Inc. | Injectable sustained release delivery system with loperamide |
Also Published As
| Publication number | Publication date |
|---|---|
| NO20050366L (no) | 2005-03-23 |
| TWI353854B (en) | 2011-12-11 |
| PL207147B1 (pl) | 2010-11-30 |
| CN1671357A (zh) | 2005-09-21 |
| CA2492047C (en) | 2014-08-12 |
| MA27371A1 (fr) | 2005-06-01 |
| RU2005101640A (ru) | 2005-08-10 |
| WO2004000269A1 (en) | 2003-12-31 |
| ZA200500677B (en) | 2006-08-30 |
| AR039729A1 (es) | 2005-03-09 |
| BR0312033A (pt) | 2005-04-26 |
| TW200404578A (en) | 2004-04-01 |
| EP1515697B1 (en) | 2014-11-19 |
| ECSP055566A (es) | 2005-04-18 |
| CN1671357B (zh) | 2010-08-11 |
| ES2530874T3 (es) | 2015-03-06 |
| KR20050026414A (ko) | 2005-03-15 |
| MXPA05000199A (es) | 2005-06-06 |
| KR101172721B1 (ko) | 2012-08-30 |
| CA2492047A1 (en) | 2003-12-31 |
| IL165865A0 (en) | 2006-01-15 |
| EP2311431A1 (en) | 2011-04-20 |
| AU2003245643A1 (en) | 2004-01-06 |
| EP2316421A1 (en) | 2011-05-04 |
| JP2011068670A (ja) | 2011-04-07 |
| HK1082412A1 (en) | 2006-06-09 |
| PL373123A1 (en) | 2005-08-08 |
| NZ574443A (en) | 2010-08-27 |
| JP2005533081A (ja) | 2005-11-04 |
| JP5631708B2 (ja) | 2014-11-26 |
| AU2003245643B2 (en) | 2009-02-26 |
| EP1515697A1 (en) | 2005-03-23 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20130626 |