RU2298012C2 - Улучшенные хелатные конъюгаты - Google Patents

Улучшенные хелатные конъюгаты Download PDF

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Publication number
RU2298012C2
RU2298012C2 RU2003137592/04A RU2003137592A RU2298012C2 RU 2298012 C2 RU2298012 C2 RU 2298012C2 RU 2003137592/04 A RU2003137592/04 A RU 2003137592/04A RU 2003137592 A RU2003137592 A RU 2003137592A RU 2298012 C2 RU2298012 C2 RU 2298012C2
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RU
Russia
Prior art keywords
compound
group
mmol
acid
radioactive
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RU2003137592/04A
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English (en)
Russian (ru)
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RU2003137592A (ru
Inventor
Колин Милл АРЧЕР (GB)
Колин Милл АРЧЕР
Гарри Джон УОДСВОРТ (GB)
Гарри Джон УОДСВОРТ
Торгрим ЭНГЕЛЛ (NO)
Торгрим ЭНГЕЛЛ
Original Assignee
Джи-И Хелткер Лимитед
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Publication of RU2003137592A publication Critical patent/RU2003137592A/ru
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Publication of RU2298012C2 publication Critical patent/RU2298012C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
RU2003137592/04A 2001-07-10 2002-07-10 Улучшенные хелатные конъюгаты RU2298012C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0116815.2A GB0116815D0 (en) 2001-07-10 2001-07-10 Improved chelator conjugates
GB0116815.2 2001-07-10

Publications (2)

Publication Number Publication Date
RU2003137592A RU2003137592A (ru) 2005-05-20
RU2298012C2 true RU2298012C2 (ru) 2007-04-27

Family

ID=9918227

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003137592/04A RU2298012C2 (ru) 2001-07-10 2002-07-10 Улучшенные хелатные конъюгаты

Country Status (20)

Country Link
US (2) US7597875B2 (enExample)
EP (1) EP1404377B1 (enExample)
JP (1) JP5015409B2 (enExample)
KR (1) KR100892009B1 (enExample)
CN (4) CN101537190A (enExample)
AT (1) ATE304866T1 (enExample)
AU (1) AU2002317317B2 (enExample)
BR (1) BR0210965A (enExample)
CA (1) CA2450690C (enExample)
DE (1) DE60206272T2 (enExample)
DK (1) DK1404377T3 (enExample)
ES (1) ES2250671T3 (enExample)
GB (1) GB0116815D0 (enExample)
HU (1) HU228850B1 (enExample)
IL (1) IL159388A0 (enExample)
MX (1) MXPA04000210A (enExample)
NO (1) NO334093B1 (enExample)
RU (1) RU2298012C2 (enExample)
WO (1) WO2003006070A2 (enExample)
ZA (1) ZA200400143B (enExample)

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* Cited by examiner, † Cited by third party
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WO2002054088A2 (en) 2001-01-05 2002-07-11 Duke University Contrast enhancement agent for magnetic resonance imaging
CN1622830A (zh) * 2001-07-10 2005-06-01 安盛药业有限公司 肽基化合物
NO20030115D0 (no) 2003-01-09 2003-01-09 Amersham Health As Kontrastmiddel
EP1699495A2 (en) * 2003-11-06 2006-09-13 Amersham Health AS Conjugates of angiotensin ii and an imaging moiety
GB0416062D0 (en) * 2004-07-19 2004-08-18 Amersham Plc Improved N4 chelator conjugates
US7431914B2 (en) 2003-11-24 2008-10-07 Ge Healthcare As Contrast agent
DE602005017475D1 (de) * 2004-03-04 2009-12-17 Ge Healthcare As Konjugate von angiotensin-peptid analoga und chelatbildner für diagnose und therapie
KR20070091609A (ko) 2004-11-22 2007-09-11 지이 헬스케어 에이에스 세포외 기질을 표적화하기 위한 조영제
GB0427392D0 (en) * 2004-12-15 2005-01-19 Amersham Plc Stabilised 99mTc compositions
WO2006131803A2 (en) * 2005-06-08 2006-12-14 Ge Healthcare Limited Method for the use of [11c] carbon monoxide in labeling synthesis of 11c-labelled esters and acids by sensitized photo-induced free radical carbonylation
GB0515974D0 (en) * 2005-08-03 2005-09-07 Ge Healthcare Ltd Compounds and imaging methods
JP5290773B2 (ja) 2006-02-15 2013-09-18 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
US7943117B2 (en) * 2006-06-08 2011-05-17 Atomic Energy Council—Institute of Nuclear Research Method for testing radiochemical purity of Tc-99m-TRODAT-1
ES2346595T3 (es) * 2006-12-11 2010-10-18 Ge Healthcare As Compuestos basados en peptidos radiomarcados y usos de los mismos.
DK3098225T3 (en) 2008-12-02 2019-03-25 Univ Melbourne NITROGEN CONTAINING MACROCYCLIC CONJUGATES AS RADIO PHARMACY
GB0922014D0 (en) 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel integrin binders
ES2804509T3 (es) 2010-07-27 2021-02-08 Serac Healthcare Ltd Composiciones radiofarmacéuticas
GB201103696D0 (en) * 2011-03-04 2011-04-20 Ge Healthcare Ltd Technetium labelled peptides
GB201110767D0 (en) 2011-06-24 2011-08-10 Ge Healthcare Ltd Infection imaging
US20130195756A1 (en) 2012-01-31 2013-08-01 General Electric Company 99mTc IMAGING AGENTS AND METHODS OF USE
AU2014216515A1 (en) * 2013-02-15 2015-10-08 Thomas Jefferson University Kit for tumor imaging
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
WO2015140212A1 (en) 2014-03-19 2015-09-24 Universität Zürich Multidentate bifunctional chelating agents for radionuclide complexation in diagnostics and therapy
JP7495126B2 (ja) * 2018-05-08 2024-06-04 ユニヴァーシティー オブ マイアミ 組織への治療用核酸の送達のための材料および方法
US11844846B2 (en) 2018-05-16 2023-12-19 Emory University Styrylbenzothiazole derivatives and uses in imaging methods
CN111548275A (zh) * 2020-05-27 2020-08-18 龙曦宁（上海）医药科技有限公司 一种2-（氨基甲基）-n1,n1-二甲基丙烷-1,3-二胺三盐酸盐的合成方法

Citations (3)

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Publication number Priority date Publication date Assignee Title
RU97118152A (ru) * 1995-03-31 1999-08-10 Диатайд, Инк. Меченые радиоактивным изотопом пептиды для диагностики и терапии
WO1999060018A1 (en) * 1998-05-15 1999-11-25 Nycomed Amersham Plc Labelled glutamine and lysine analogues
US5997843A (en) * 1993-08-04 1999-12-07 Amersham International Plc Radiometal complexes that localise in hypoxic tissue

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US5997843A (en) * 1993-08-04 1999-12-07 Amersham International Plc Radiometal complexes that localise in hypoxic tissue
RU97118152A (ru) * 1995-03-31 1999-08-10 Диатайд, Инк. Меченые радиоактивным изотопом пептиды для диагностики и терапии
WO1999060018A1 (en) * 1998-05-15 1999-11-25 Nycomed Amersham Plc Labelled glutamine and lysine analogues

Also Published As

Publication number Publication date
EP1404377A2 (en) 2004-04-07
HK1064585A1 (en) 2005-02-04
CN101538313A (zh) 2009-09-23
CN1527727A (zh) 2004-09-08
MXPA04000210A (es) 2004-07-23
ES2250671T3 (es) 2006-04-16
GB0116815D0 (en) 2001-08-29
CA2450690C (en) 2009-03-24
NO20035597L (no) 2004-03-03
IL159388A0 (en) 2004-06-01
US20100040542A1 (en) 2010-02-18
CN101607913A (zh) 2009-12-23
JP2005500325A (ja) 2005-01-06
AU2002317317B2 (en) 2005-11-17
US7597875B2 (en) 2009-10-06
KR20040017287A (ko) 2004-02-26
DE60206272T2 (de) 2006-07-13
CN101607913B (zh) 2012-07-04
RU2003137592A (ru) 2005-05-20
HUP0401265A2 (hu) 2004-09-28
CN100509061C (zh) 2009-07-08
ATE304866T1 (de) 2005-10-15
ZA200400143B (en) 2004-12-29
CN101537190A (zh) 2009-09-23
BR0210965A (pt) 2004-06-08
EP1404377B1 (en) 2005-09-21
WO2003006070A2 (en) 2003-01-23
HU228850B1 (en) 2013-06-28
DE60206272D1 (de) 2005-10-27
DK1404377T3 (da) 2006-01-30
HUP0401265A3 (en) 2005-11-28
JP5015409B2 (ja) 2012-08-29
WO2003006070A3 (en) 2003-08-21
US8852550B2 (en) 2014-10-07
KR100892009B1 (ko) 2009-04-07
NO334093B1 (no) 2013-12-09
NO20035597D0 (no) 2003-12-16
CA2450690A1 (en) 2003-01-23
US20040258619A1 (en) 2004-12-23

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Effective date: 20140711