CA2450690C - Improved chelator conjugates - Google Patents
Improved chelator conjugates Download PDFInfo
- Publication number
- CA2450690C CA2450690C CA002450690A CA2450690A CA2450690C CA 2450690 C CA2450690 C CA 2450690C CA 002450690 A CA002450690 A CA 002450690A CA 2450690 A CA2450690 A CA 2450690A CA 2450690 C CA2450690 C CA 2450690C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- group
- formula
- independently
- chelator conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000002738 chelating agent Substances 0.000 title claims abstract description 75
- 230000008685 targeting Effects 0.000 claims abstract description 38
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- 229940121896 radiopharmaceutical Drugs 0.000 claims abstract description 15
- 230000002799 radiopharmaceutical effect Effects 0.000 claims abstract description 15
- 150000001875 compounds Chemical class 0.000 claims description 53
- 238000006243 chemical reaction Methods 0.000 claims description 46
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- 239000000203 mixture Substances 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 22
- 238000002360 preparation method Methods 0.000 claims description 19
- 125000006239 protecting group Chemical group 0.000 claims description 18
- 125000005647 linker group Chemical group 0.000 claims description 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 16
- 125000003709 fluoroalkyl group Chemical group 0.000 claims description 15
- 125000002837 carbocyclic group Chemical group 0.000 claims description 14
- 150000001768 cations Chemical class 0.000 claims description 14
- 150000002148 esters Chemical class 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 229920006395 saturated elastomer Polymers 0.000 claims description 12
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 10
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 9
- 125000000623 heterocyclic group Chemical group 0.000 claims description 8
- 125000000732 arylene group Chemical group 0.000 claims description 7
- 239000012634 fragment Substances 0.000 claims description 7
- 239000003638 chemical reducing agent Substances 0.000 claims description 6
- 230000007935 neutral effect Effects 0.000 claims description 6
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| PCT/GB2002/003168 WO2003006070A2 (en) | 2001-07-10 | 2002-07-10 | Improved chelator conjugates |
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| WO2002054088A2 (en) | 2001-01-05 | 2002-07-11 | Duke University | Contrast enhancement agent for magnetic resonance imaging |
| CN1622830A (zh) * | 2001-07-10 | 2005-06-01 | 安盛药业有限公司 | 肽基化合物 |
| NO20030115D0 (no) | 2003-01-09 | 2003-01-09 | Amersham Health As | Kontrastmiddel |
| EP1699495A2 (en) * | 2003-11-06 | 2006-09-13 | Amersham Health AS | Conjugates of angiotensin ii and an imaging moiety |
| GB0416062D0 (en) * | 2004-07-19 | 2004-08-18 | Amersham Plc | Improved N4 chelator conjugates |
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| DE602005017475D1 (de) * | 2004-03-04 | 2009-12-17 | Ge Healthcare As | Konjugate von angiotensin-peptid analoga und chelatbildner für diagnose und therapie |
| KR20070091609A (ko) | 2004-11-22 | 2007-09-11 | 지이 헬스케어 에이에스 | 세포외 기질을 표적화하기 위한 조영제 |
| GB0427392D0 (en) * | 2004-12-15 | 2005-01-19 | Amersham Plc | Stabilised 99mTc compositions |
| WO2006131803A2 (en) * | 2005-06-08 | 2006-12-14 | Ge Healthcare Limited | Method for the use of [11c] carbon monoxide in labeling synthesis of 11c-labelled esters and acids by sensitized photo-induced free radical carbonylation |
| GB0515974D0 (en) * | 2005-08-03 | 2005-09-07 | Ge Healthcare Ltd | Compounds and imaging methods |
| JP5290773B2 (ja) | 2006-02-15 | 2013-09-18 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
| US7943117B2 (en) * | 2006-06-08 | 2011-05-17 | Atomic Energy Council—Institute of Nuclear Research | Method for testing radiochemical purity of Tc-99m-TRODAT-1 |
| ES2346595T3 (es) * | 2006-12-11 | 2010-10-18 | Ge Healthcare As | Compuestos basados en peptidos radiomarcados y usos de los mismos. |
| DK3098225T3 (en) | 2008-12-02 | 2019-03-25 | Univ Melbourne | NITROGEN CONTAINING MACROCYCLIC CONJUGATES AS RADIO PHARMACY |
| GB0922014D0 (en) | 2009-12-17 | 2010-02-03 | Ge Healthcare Ltd | Novel integrin binders |
| ES2804509T3 (es) | 2010-07-27 | 2021-02-08 | Serac Healthcare Ltd | Composiciones radiofarmacéuticas |
| GB201103696D0 (en) * | 2011-03-04 | 2011-04-20 | Ge Healthcare Ltd | Technetium labelled peptides |
| GB201110767D0 (en) | 2011-06-24 | 2011-08-10 | Ge Healthcare Ltd | Infection imaging |
| US20130195756A1 (en) | 2012-01-31 | 2013-08-01 | General Electric Company | 99mTc IMAGING AGENTS AND METHODS OF USE |
| AU2014216515A1 (en) * | 2013-02-15 | 2015-10-08 | Thomas Jefferson University | Kit for tumor imaging |
| GB201314936D0 (en) | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
| WO2015140212A1 (en) | 2014-03-19 | 2015-09-24 | Universität Zürich | Multidentate bifunctional chelating agents for radionuclide complexation in diagnostics and therapy |
| JP7495126B2 (ja) * | 2018-05-08 | 2024-06-04 | ユニヴァーシティー オブ マイアミ | 組織への治療用核酸の送達のための材料および方法 |
| US11844846B2 (en) | 2018-05-16 | 2023-12-19 | Emory University | Styrylbenzothiazole derivatives and uses in imaging methods |
| CN111548275A (zh) * | 2020-05-27 | 2020-08-18 | 龙曦宁（上海）医药科技有限公司 | 一种2-（氨基甲基）-n1,n1-二甲基丙烷-1,3-二胺三盐酸盐的合成方法 |
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| GB1588978A (en) * | 1977-07-19 | 1981-05-07 | Ici Ltd | Coating processes |
| DE3930674A1 (de) * | 1989-09-11 | 1991-03-21 | Diagnostikforschung Inst | Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| US5808091A (en) * | 1991-10-29 | 1998-09-15 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia localizing moiety |
| HUT73672A (en) * | 1993-08-04 | 1996-09-30 | Amersham Int Plc | Radiometal complexes that localise in hypoxic tissue |
| ES2114735T3 (es) * | 1994-01-12 | 1998-06-01 | Bracco Int Bv | Ligandos y complejos metalicos de los mismos. |
| US5705143A (en) * | 1994-01-12 | 1998-01-06 | Amersham International Plc | Biological targeting agents |
| DE69937996T2 (de) * | 1998-05-15 | 2009-01-02 | Ge Healthcare Ltd., Little Chalfont | Markierte glutamin- und lysinanaloge |
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| US6988794B2 (en) * | 2001-03-08 | 2006-01-24 | Matsushita Electric Industrial Co., Ltd. | Inkjet recording ink, method for producing said ink, and ink cartridge and recording device having said ink |
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- 2002-07-10 CA CA002450690A patent/CA2450690C/en not_active Expired - Lifetime
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