CA2450690C - Improved chelator conjugates - Google Patents
Improved chelator conjugates Download PDFInfo
- Publication number
- CA2450690C CA2450690C CA002450690A CA2450690A CA2450690C CA 2450690 C CA2450690 C CA 2450690C CA 002450690 A CA002450690 A CA 002450690A CA 2450690 A CA2450690 A CA 2450690A CA 2450690 C CA2450690 C CA 2450690C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- group
- formula
- independently
- chelator conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000002738 chelating agent Substances 0.000 title claims abstract description 75
- 230000008685 targeting Effects 0.000 claims abstract description 38
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- 229940121896 radiopharmaceutical Drugs 0.000 claims abstract description 15
- 230000002799 radiopharmaceutical effect Effects 0.000 claims abstract description 15
- 150000001875 compounds Chemical class 0.000 claims description 53
- 238000006243 chemical reaction Methods 0.000 claims description 46
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- 239000000203 mixture Substances 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 22
- 238000002360 preparation method Methods 0.000 claims description 19
- 125000006239 protecting group Chemical group 0.000 claims description 18
- 125000005647 linker group Chemical group 0.000 claims description 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 16
- 125000003709 fluoroalkyl group Chemical group 0.000 claims description 15
- 125000002837 carbocyclic group Chemical group 0.000 claims description 14
- 150000001768 cations Chemical class 0.000 claims description 14
- 150000002148 esters Chemical class 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 229920006395 saturated elastomer Polymers 0.000 claims description 12
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 10
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 9
- 125000000623 heterocyclic group Chemical group 0.000 claims description 8
- 125000000732 arylene group Chemical group 0.000 claims description 7
- 239000012634 fragment Substances 0.000 claims description 7
- 239000003638 chemical reducing agent Substances 0.000 claims description 6
- 230000007935 neutral effect Effects 0.000 claims description 6
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- C—CHEMISTRY; METALLURGY
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| CA2433657A1 (en) * | 2001-01-05 | 2002-07-11 | Duke University | Contrast enhancement agent for magnetic resonance imaging |
| CN1622830A (zh) * | 2001-07-10 | 2005-06-01 | 安盛药业有限公司 | 肽基化合物 |
| NO20030115D0 (no) | 2003-01-09 | 2003-01-09 | Amersham Health As | Kontrastmiddel |
| US7785566B2 (en) | 2003-11-06 | 2010-08-31 | Ge Healthcare, Inc. | Pharmaceutical compounds |
| GB0416062D0 (en) | 2004-07-19 | 2004-08-18 | Amersham Plc | Improved N4 chelator conjugates |
| US7431914B2 (en) | 2003-11-24 | 2008-10-07 | Ge Healthcare As | Contrast agent |
| CN1925876A (zh) * | 2004-03-04 | 2007-03-07 | 通用电气医疗集团股份有限公司 | 用于诊断和治疗的血管紧张素肽类似物和螯合剂的缀合物 |
| AU2005307195A1 (en) * | 2004-11-22 | 2006-05-26 | Ge Healthcare As | Contrast agents to target extracellular matrix |
| GB0427392D0 (en) * | 2004-12-15 | 2005-01-19 | Amersham Plc | Stabilised 99mTc compositions |
| US20080226555A1 (en) * | 2005-06-08 | 2008-09-18 | Bengt Langstrom | Method for the Use of [11C] Carbon Monoxide in Labeling Synthesis of 11C-Labelled Esters and Acids by Sensitized Photo-Induced Free Radical |
| GB0515974D0 (en) * | 2005-08-03 | 2005-09-07 | Ge Healthcare Ltd | Compounds and imaging methods |
| DE602007012208D1 (de) | 2006-02-15 | 2011-03-10 | Ge Healthcare As | Kontrastmittel |
| US7943117B2 (en) * | 2006-06-08 | 2011-05-17 | Atomic Energy Council—Institute of Nuclear Research | Method for testing radiochemical purity of Tc-99m-TRODAT-1 |
| WO2008072973A2 (en) * | 2006-12-11 | 2008-06-19 | Ge Healthcare As | Radiolabelled peptide based compounds and uses thereof |
| ES2712881T3 (es) | 2008-12-02 | 2019-05-16 | Univ Melbourne | Conjugados macrocíclicos que contienen nitrógeno como radiofármacos |
| GB0922014D0 (en) | 2009-12-17 | 2010-02-03 | Ge Healthcare Ltd | Novel integrin binders |
| ES2804509T3 (es) | 2010-07-27 | 2021-02-08 | Serac Healthcare Ltd | Composiciones radiofarmacéuticas |
| GB201103696D0 (en) | 2011-03-04 | 2011-04-20 | Ge Healthcare Ltd | Technetium labelled peptides |
| GB201110767D0 (en) | 2011-06-24 | 2011-08-10 | Ge Healthcare Ltd | Infection imaging |
| US20130195756A1 (en) | 2012-01-31 | 2013-08-01 | General Electric Company | 99mTc IMAGING AGENTS AND METHODS OF USE |
| CA2901231C (en) * | 2013-02-15 | 2020-06-23 | Thomas Jefferson University | Kit comprising lyophilized compositions for tumor imaging |
| GB201314936D0 (en) | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
| US11033642B2 (en) | 2014-03-19 | 2021-06-15 | Universitat Zurich | Multidentate bifunctional chelating agents for radionuclide complexation in diagnostics and therapy |
| CN112840025A (zh) * | 2018-05-08 | 2021-05-25 | 迈阿密大学 | 用于将治疗性核酸递送到组织的材料方法 |
| CN112105393A (zh) | 2018-05-16 | 2020-12-18 | 爱默蕾大学 | 苯乙烯基苯并噻唑衍生物及在成像中的用途 |
| CN111548275A (zh) * | 2020-05-27 | 2020-08-18 | 龙曦宁（上海）医药科技有限公司 | 一种2-（氨基甲基）-n1,n1-二甲基丙烷-1,3-二胺三盐酸盐的合成方法 |
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| GB1588978A (en) * | 1977-07-19 | 1981-05-07 | Ici Ltd | Coating processes |
| DE3930674A1 (de) * | 1989-09-11 | 1991-03-21 | Diagnostikforschung Inst | Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| US5808091A (en) * | 1991-10-29 | 1998-09-15 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia localizing moiety |
| US5997843A (en) * | 1993-08-04 | 1999-12-07 | Amersham International Plc | Radiometal complexes that localise in hypoxic tissue |
| CA2156605A1 (en) * | 1994-01-12 | 1995-07-20 | Bracco International B.V. | Ligands and metal complexes thereof |
| CA2179990A1 (en) * | 1994-01-12 | 1995-07-20 | Gary Robert Bower | Biological targeting agents |
| RU2205186C2 (ru) * | 1998-05-15 | 2003-05-27 | Амершам Плк | Меченые аналоги глутамина и лизина |
| US6783711B2 (en) * | 2000-05-23 | 2004-08-31 | Ge Osmonics, Inc. | Process for preparing a sulfonamide polymer matrix |
| US6988794B2 (en) * | 2001-03-08 | 2006-01-24 | Matsushita Electric Industrial Co., Ltd. | Inkjet recording ink, method for producing said ink, and ink cartridge and recording device having said ink |
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