DK3131585T3 - Multidentate, bifunktionelle chelateringsmidler til radionuklidkompleksdannelse i diagnostik og terapi - Google Patents
Multidentate, bifunktionelle chelateringsmidler til radionuklidkompleksdannelse i diagnostik og terapi Download PDFInfo
- Publication number
- DK3131585T3 DK3131585T3 DK15710778.0T DK15710778T DK3131585T3 DK 3131585 T3 DK3131585 T3 DK 3131585T3 DK 15710778 T DK15710778 T DK 15710778T DK 3131585 T3 DK3131585 T3 DK 3131585T3
- Authority
- DK
- Denmark
- Prior art keywords
- radionuclid
- multidentate
- diagnostics
- therapy
- chelating agents
- Prior art date
Links
- 239000002738 chelating agent Substances 0.000 title 1
- 230000009918 complex formation Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 0 CCCC[C@@](*C(C(CC(C)C)*C([C@](CC(*=CC)=CC)*C(C*C(C(*C([C@](C)*C([C@](CC1=C*c2ccccc12)*C([C@](CCC(*)=O)C(C(CC*C(CC*C(CC*C(CCC(*CCCCC*(C(CCC(*CCCCC*(C(CCC(*CCCCCC(C(CCC(*CCCCC*(C(C)=O)O)=O)=O)O)=O)=O)O)=O)=O)O)=I=C)=O)=O)=O)=O)=C)=O)=O)=*)C(C)C)=O)=O)=O)=O)C(*)=O Chemical compound CCCC[C@@](*C(C(CC(C)C)*C([C@](CC(*=CC)=CC)*C(C*C(C(*C([C@](C)*C([C@](CC1=C*c2ccccc12)*C([C@](CCC(*)=O)C(C(CC*C(CC*C(CC*C(CCC(*CCCCC*(C(CCC(*CCCCC*(C(CCC(*CCCCCC(C(CCC(*CCCCC*(C(C)=O)O)=O)=O)O)=O)=O)O)=O)=O)O)=I=C)=O)=O)=O)=O)=C)=O)=O)=*)C(C)C)=O)=O)=O)=O)C(*)=O 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/26—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/48—Polymers modified by chemical after-treatment
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14160792 | 2014-03-19 | ||
| PCT/EP2015/055684 WO2015140212A1 (en) | 2014-03-19 | 2015-03-18 | Multidentate bifunctional chelating agents for radionuclide complexation in diagnostics and therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3131585T3 true DK3131585T3 (da) | 2020-10-19 |
Family
ID=50289571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15710778.0T DK3131585T3 (da) | 2014-03-19 | 2015-03-18 | Multidentate, bifunktionelle chelateringsmidler til radionuklidkompleksdannelse i diagnostik og terapi |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11033642B2 (da) |
| EP (1) | EP3131585B1 (da) |
| DK (1) | DK3131585T3 (da) |
| ES (1) | ES2824674T3 (da) |
| HU (1) | HUE050988T2 (da) |
| PT (1) | PT3131585T (da) |
| WO (1) | WO2015140212A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017096430A1 (en) * | 2015-12-09 | 2017-06-15 | The University Of Sydney | Hydroxamic acid-based compounds |
| CN106008256B (zh) * | 2016-06-01 | 2018-11-09 | 上海市伤骨科研究所 | 一种具有趋骨性的去铁敏衍生化合物及其制备方法和应用 |
| TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法 |
| US10736976B2 (en) | 2016-12-01 | 2020-08-11 | Regeneron Pharmaceuticals, Inc. | Radiolabeled anti-PD-L1 antibodies for immuno-PET imaging |
| MA47456A (fr) | 2017-02-10 | 2019-12-18 | Regeneron Pharma | Anticorps anti-lag3 radiomarqués pour imagerie immuno-pet |
| US10730944B2 (en) | 2017-07-24 | 2020-08-04 | Regeneron Pharmaceuticals, Inc. | Anti-CD8 antibodies and uses thereof |
| CN113993547B (zh) | 2019-06-21 | 2024-04-26 | 瑞泽恩制药公司 | 结合muc16和cd3的双特异性抗原结合分子与4-1bb共刺激组合的用途 |
| JP2022537019A (ja) | 2019-06-21 | 2022-08-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｐｓｍａおよびｃｄ３に結合する二重特異性抗原結合分子の４－１ｂｂ共刺激と組み合わせての使用 |
| CN114340684A (zh) | 2019-09-16 | 2022-04-12 | 瑞泽恩制药公司 | 用于免疫pet成像的放射性标记的met结合蛋白 |
| AU2021377185A1 (en) | 2020-11-10 | 2023-06-08 | Regeneron Pharmaceuticals, Inc. | Selenium antibody conjugates |
| WO2023224974A1 (en) * | 2022-05-20 | 2023-11-23 | Brookhaven Science Associates, Llc. | Alkyl-substituted hydroxamate resin for use in a generator system |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1098659A4 (en) * | 1998-07-23 | 2004-11-24 | Metaphore Inc | POLYHYDROXAMATE BANKS AND THEIR ANALOG |
| GB0116815D0 (en) | 2001-07-10 | 2001-08-29 | Nycomed Amersham Plc | Improved chelator conjugates |
| US7728038B2 (en) * | 2004-08-04 | 2010-06-01 | University Of Utah Research Foundation | Methods for chelation therapy |
| EP2215052B1 (en) * | 2007-11-01 | 2013-07-24 | Rachel Codd | Desferrioxamine conjugates, derivatives and analogues |
| EP2604281B1 (en) | 2011-12-14 | 2014-07-30 | Centre National de la Recherche Scientifique (CNRS) | Clicked somatostatin conjugated analogs for biological applications |
| US10137212B2 (en) * | 2013-03-13 | 2018-11-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tetrahydroxamate chelators of zirconium89 and niobium90 for use in diagnostic applications |
-
2015
- 2015-03-18 ES ES15710778T patent/ES2824674T3/es active Active
- 2015-03-18 US US15/127,025 patent/US11033642B2/en active Active
- 2015-03-18 DK DK15710778.0T patent/DK3131585T3/da active
- 2015-03-18 HU HUE15710778A patent/HUE050988T2/hu unknown
- 2015-03-18 PT PT157107780T patent/PT3131585T/pt unknown
- 2015-03-18 WO PCT/EP2015/055684 patent/WO2015140212A1/en active Application Filing
- 2015-03-18 EP EP15710778.0A patent/EP3131585B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015140212A1 (en) | 2015-09-24 |
| ES2824674T3 (es) | 2021-05-13 |
| HUE050988T2 (hu) | 2021-01-28 |
| EP3131585B1 (en) | 2020-07-15 |
| US20170106106A1 (en) | 2017-04-20 |
| PT3131585T (pt) | 2020-10-23 |
| US11033642B2 (en) | 2021-06-15 |
| EP3131585A1 (en) | 2017-02-22 |
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