RU2292342C2 - Производные бензимидазола и их применение в качестве пролекарств ингибиторов протонного насоса - Google Patents
Производные бензимидазола и их применение в качестве пролекарств ингибиторов протонного насоса Download PDFInfo
- Publication number
- RU2292342C2 RU2292342C2 RU2005105564/04A RU2005105564A RU2292342C2 RU 2292342 C2 RU2292342 C2 RU 2292342C2 RU 2005105564/04 A RU2005105564/04 A RU 2005105564/04A RU 2005105564 A RU2005105564 A RU 2005105564A RU 2292342 C2 RU2292342 C2 RU 2292342C2
- Authority
- RU
- Russia
- Prior art keywords
- sulfonyl
- compound
- mixture
- methoxy
- acid
- Prior art date
Links
- 0 Cc1ccc(*)c(*)c1 Chemical compound Cc1ccc(*)c(*)c1 0.000 description 2
- IQPSEEYGBUAQFF-UHFFFAOYSA-N COc1ccnc(CS(c2nc3cc(OC(F)F)ccc3[nH]2)=O)c1OC Chemical compound COc1ccnc(CS(c2nc3cc(OC(F)F)ccc3[nH]2)=O)c1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 description 1
- QBMWWQZPWBZGJS-UHFFFAOYSA-N Cc1cc(OCC(NC(CCC(O)=O)C(O)=O)=O)cc(C)c1S(=O)=O Chemical compound Cc1cc(OCC(NC(CCC(O)=O)C(O)=O)=O)cc(C)c1S(=O)=O QBMWWQZPWBZGJS-UHFFFAOYSA-N 0.000 description 1
- MEIYXFWRJKDWNG-UHFFFAOYSA-N Cc1cc([O](C)CC(NCCCC(O)=O)=O)cc(C)c1S(=O)=O Chemical compound Cc1cc([O](C)CC(NCCCC(O)=O)=O)cc(C)c1S(=O)=O MEIYXFWRJKDWNG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39745902P | 2002-07-19 | 2002-07-19 | |
US60/397459 | 2002-07-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2005105564A RU2005105564A (ru) | 2005-10-10 |
RU2292342C2 true RU2292342C2 (ru) | 2007-01-27 |
Family
ID=30771064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2005105564/04A RU2292342C2 (ru) | 2002-07-19 | 2003-07-15 | Производные бензимидазола и их применение в качестве пролекарств ингибиторов протонного насоса |
Country Status (23)
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6852739B1 (en) * | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
CA2493618A1 (en) * | 2002-08-01 | 2004-02-12 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
NZ544173A (en) * | 2003-07-15 | 2009-04-30 | Alevium Pharmaceuticals Inc | Process for preparing isomerically pure prodrugs of benzimidazole derivative proton pump inhibitors |
WO2005039640A1 (en) * | 2003-10-03 | 2005-05-06 | Allergan Inc. | Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs |
US20050075371A1 (en) * | 2003-10-03 | 2005-04-07 | Allergan, Inc. | Methods and compositions for the oral administration of prodrugs of proton pump inhibitors |
CA2557471A1 (en) * | 2004-02-18 | 2005-09-09 | Allergan, Inc. | Methods and compositions for the intravenous administration of compounds related to proton pump inhibitors |
JP2007523163A (ja) * | 2004-02-18 | 2007-08-16 | アラーガン、インコーポレイテッド | プロトンポンプインヒビターのプロドラッグの投与のための方法および組成物 |
EP1722794A1 (en) * | 2004-03-11 | 2006-11-22 | Allergan, Inc. | Methods and compositions for the treatment of conditions related to gastric acid secretion |
PT1740571E (pt) | 2004-04-28 | 2009-09-02 | Hetero Drugs Ltd | Processo para preparar compostos de piridinilmetil-1hbenzimidazol na forma enantiomericamente enriquecida ou como enantiómeros únicos |
WO2007073301A1 (en) * | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Benzoimidazole derivatives as prodrugs of proton pump inhibitors |
US20070265311A1 (en) * | 2006-01-10 | 2007-11-15 | Rubino Mark P | Therapeutic Salt Compositions and Methods |
BRPI0711048A2 (pt) * | 2006-05-09 | 2011-08-23 | Astrazeneca Ab | formulações parenteral esterilizada e sólida estáveis, solução para administração parenteral, processos para a preparação de uma formulação e para a fabricação de um produto, método para prevenir ou tratar doenças gastrintestinais, uso de uma formulação sólida estável |
US20070293543A1 (en) * | 2006-06-19 | 2007-12-20 | Edward Lee | THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z |
WO2008036211A1 (en) * | 2006-09-19 | 2008-03-27 | Alevium Pharmaceuticals, Inc. | Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety |
US20100317689A1 (en) * | 2006-09-19 | 2010-12-16 | Garst Michael E | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
KR20090035195A (ko) * | 2007-10-05 | 2009-04-09 | 엘지전자 주식회사 | 플라즈마 디스플레이 장치 |
WO2009044976A1 (en) * | 2007-10-05 | 2009-04-09 | Lg Electronics Inc. | Plasma display device |
KR100895333B1 (ko) * | 2007-11-01 | 2009-05-07 | 엘지전자 주식회사 | 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치 |
WO2012051036A1 (en) | 2010-10-11 | 2012-04-19 | Merck Sharp & Dohme Corp. | Quinazolinone-type compounds as crth2 antagonists |
WO2012087872A1 (en) | 2010-12-23 | 2012-06-28 | Merck Sharp & Dohme Corp. | Quinolines and aza-quinolines as crth2 receptor modulators |
ES2635030T3 (es) | 2010-12-23 | 2017-10-02 | Merck Sharp & Dohme Corp. | Quinoxalinas y aza-quinoxalinas como moduladores del receptor CRTH2 |
CA2973370A1 (en) * | 2015-01-09 | 2016-07-14 | The Regents Of The University Of California | Compositions and methods for treating gastrointestinal infections |
CN108997177A (zh) * | 2018-09-04 | 2018-12-14 | 邵阳学院 | 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US430042A (en) * | 1890-06-10 | Valve | ||
SE416649B (sv) * | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
JPS6150978A (ja) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
IL76839A (en) * | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
SE8505112D0 (sv) * | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
US4758597A (en) * | 1987-05-15 | 1988-07-19 | University Patents, Inc. | Carenadiol and derivatives |
US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
US5045522A (en) * | 1990-03-27 | 1991-09-03 | Phillips Petroleum Company | Absorption composition comprising zinc titanate for removal of hydrogen sulfide from fluid streams |
CA2083606C (en) * | 1990-06-20 | 2001-08-21 | Arne Elof Brandstrom | Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use |
SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
NZ288609A (en) * | 1994-06-10 | 1998-12-23 | Byk Gulden Lomberg Chem Fab | Substituted (4-thiopyridinyl) methylthio-benzimidazole (or 1h-imidazo-[2,3-b]-pyridine) and medicaments |
US5708017A (en) * | 1995-04-04 | 1998-01-13 | Merck & Co., Inc. | Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors |
US6093734A (en) * | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
DE69905171T2 (de) | 1998-08-10 | 2003-11-20 | Winston Pharmaceuticals Llc Ne | Prodrugs für proton-pump-inhibitoren |
KR100687194B1 (ko) * | 1998-08-12 | 2007-02-27 | 길리애드 사이언시즈, 인코포레이티드 | 1,3-옥사티올란 뉴클레오시드의 제조 방법 |
SE0002476D0 (sv) | 2000-06-30 | 2000-06-30 | Astrazeneca Ab | New compounds |
US6599167B2 (en) * | 2000-09-27 | 2003-07-29 | Glenn Waltz | Game call holder and amplifying device |
WO2002030920A1 (fr) * | 2000-10-12 | 2002-04-18 | Takeda Chemical Industries, Ltd. | Composes derives de benzimidazole, leur procede de production et leur utilisation |
-
2003
- 2003-07-15 KR KR1020057000899A patent/KR100788778B1/ko not_active IP Right Cessation
- 2003-07-15 AU AU2003259154A patent/AU2003259154B2/en not_active Ceased
- 2003-07-15 DK DK03765694T patent/DK1556371T3/da active
- 2003-07-15 NZ NZ538221A patent/NZ538221A/en unknown
- 2003-07-15 US US10/620,252 patent/US6897227B2/en not_active Expired - Lifetime
- 2003-07-15 CA CA2492718A patent/CA2492718C/en not_active Expired - Lifetime
- 2003-07-15 RU RU2005105564/04A patent/RU2292342C2/ru not_active IP Right Cessation
- 2003-07-15 BR BR0312802-4A patent/BR0312802A/pt not_active IP Right Cessation
- 2003-07-15 WO PCT/US2003/022419 patent/WO2004009583A2/en active IP Right Grant
- 2003-07-15 PT PT03765694T patent/PT1556371E/pt unknown
- 2003-07-15 DE DE60304726T patent/DE60304726T2/de not_active Expired - Lifetime
- 2003-07-15 MX MXPA05000657A patent/MXPA05000657A/es active IP Right Grant
- 2003-07-15 JP JP2004523537A patent/JP4463103B2/ja not_active Expired - Fee Related
- 2003-07-15 KR KR1020067026729A patent/KR100822981B1/ko not_active IP Right Cessation
- 2003-07-15 PL PL03375255A patent/PL375255A1/xx not_active Application Discontinuation
- 2003-07-15 EP EP03765694A patent/EP1556371B1/en not_active Expired - Lifetime
- 2003-07-15 ES ES03765694T patent/ES2263028T3/es not_active Expired - Lifetime
- 2003-07-15 AT AT03765694T patent/ATE323695T1/de not_active IP Right Cessation
- 2003-11-07 TW TW092131253A patent/TW200502231A/zh unknown
-
2005
- 2005-01-18 IL IL16637105A patent/IL166371A0/xx unknown
- 2005-01-20 US US11/039,630 patent/US20050182101A1/en not_active Abandoned
- 2005-01-20 US US11/039,631 patent/US20050143423A1/en not_active Abandoned
- 2005-02-08 ZA ZA200501116A patent/ZA200501116B/xx unknown
- 2005-02-15 CO CO05013468A patent/CO5690576A2/es not_active Application Discontinuation
- 2005-02-15 NO NO20050801A patent/NO20050801L/no not_active Application Discontinuation
-
2006
- 2006-01-11 HK HK06100445A patent/HK1079207A1/xx not_active IP Right Cessation
Non-Patent Citations (1)
Title |
---|
KAMINSKI J.J. et al. «Antiulcer agents. 5. Inhibition of gastric H+/K+-atpase by substituted imidazol 1,2-A Pyridines and related analogues and its implication in modeling the high affinity potassium ion binding site of the gastric proton pump enzyme», J.Med.Chem., v.34, 1991, pp.533-541. * |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20100716 |