RU2268716C2 - Способ применения ингибиторов циклооксигеназы-2 в качестве антиангиогенных средств - Google Patents

Способ применения ингибиторов циклооксигеназы-2 в качестве антиангиогенных средств Download PDF

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Publication number
RU2268716C2
RU2268716C2 RU99112952/14A RU99112952A RU2268716C2 RU 2268716 C2 RU2268716 C2 RU 2268716C2 RU 99112952/14 A RU99112952/14 A RU 99112952/14A RU 99112952 A RU99112952 A RU 99112952A RU 2268716 C2 RU2268716 C2 RU 2268716C2
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Russia
Prior art keywords
radicals
benzenesulfonamide
pyrazol
phenyl
trifluoromethyl
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RU99112952/14A
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English (en)
Russian (ru)
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RU99112952A (ru
Inventor
Джэйм Л. МАСФЕРРЕР (US)
Джэйм Л. МАСФЕРРЕР
Амирам РАЗ (IL)
Амирам РАЗ
Original Assignee
Джи. Ди. Сирл Энд Ко
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Application filed by Джи. Ди. Сирл Энд Ко filed Critical Джи. Ди. Сирл Энд Ко
Publication of RU99112952A publication Critical patent/RU99112952A/ru
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Publication of RU2268716C2 publication Critical patent/RU2268716C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
RU99112952/14A 1996-11-19 1997-11-19 Способ применения ингибиторов циклооксигеназы-2 в качестве антиангиогенных средств RU2268716C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3140496P 1996-11-19 1996-11-19
US60/031,404 1996-11-19

Publications (2)

Publication Number Publication Date
RU99112952A RU99112952A (ru) 2001-05-27
RU2268716C2 true RU2268716C2 (ru) 2006-01-27

Family

ID=21859277

Family Applications (1)

Application Number Title Priority Date Filing Date
RU99112952/14A RU2268716C2 (ru) 1996-11-19 1997-11-19 Способ применения ингибиторов циклооксигеназы-2 в качестве антиангиогенных средств

Country Status (19)

Country Link
EP (1) EP0941080A2 (fr)
JP (1) JP2001505564A (fr)
KR (1) KR20000053362A (fr)
CN (1) CN1247470A (fr)
AU (1) AU730211B2 (fr)
BR (1) BR9713522A (fr)
CA (1) CA2270469C (fr)
CZ (1) CZ176899A3 (fr)
ID (1) ID21979A (fr)
IL (1) IL129604A (fr)
NO (1) NO992309D0 (fr)
NZ (1) NZ335853A (fr)
PL (2) PL194717B1 (fr)
RO (1) RO118566B1 (fr)
RU (1) RU2268716C2 (fr)
SK (1) SK59999A3 (fr)
TR (1) TR199901703T2 (fr)
UA (1) UA70294C2 (fr)
WO (1) WO1998022101A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2472523C2 (ru) * 2006-08-16 2013-01-20 Марлин Ньютрасьютикалз, Инк. Лечение глазных болезней
RU2684315C2 (ru) * 2011-11-01 2019-04-05 Валиркс Плк Медицинское применение

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515014B2 (en) 1995-06-02 2003-02-04 G. D. Searle & Co. Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US6512121B2 (en) 1998-09-14 2003-01-28 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
NZ333399A (en) 1997-12-24 2000-05-26 Sankyo Co Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US20030013739A1 (en) * 1998-12-23 2003-01-16 Pharmacia Corporation Methods of using a combination of cyclooxygenase-2 selective inhibitors and thalidomide for the treatment of neoplasia
WO2000038715A2 (fr) * 1998-12-23 2000-07-06 G.D. Searle & Co. Procede d'utilisation d'un antagoniste de l'integrine et radiotherapie en tant que polytherapie dans le traitement des neoplasies
ES2249253T3 (es) * 1999-03-10 2006-04-01 G.D. Searle Llc Metodo y composicion para administrar un inhibidor de la ciclooxigenasa-2.
EP1206256B8 (fr) * 1999-07-29 2005-06-29 Amgen, Inc. Therapie d'association comprenant l'administration de pentafluorobenzenesulfonamides
PT1282418E (pt) 2000-05-19 2005-10-31 Applied Research Systems Utilizacao de derivados pirazolo para o tratamento da infertilidade
WO2002039958A2 (fr) 2000-11-03 2002-05-23 Tularik Inc. Therapies combinees a base de pentafluorobenzenesulfonamides et d'agents antineoplasiques
KR100686537B1 (ko) * 2001-12-28 2007-02-27 씨제이 주식회사 사이클로옥시게나제-2 의 저해제로서 선택성이 뛰어난디아릴 1,2,4-트리아졸 유도체
CA2492387A1 (fr) * 2002-07-17 2004-01-22 Warner-Lambert Company Llc Combinaison d'un inhibiteur allosterique carboxylique de la metalloproteinase matricielle 13 avec un inhibiteur selectif de la cyclooxygenase-2 qui n'est pas un celecoxib ou un valdecoxib
KR100484525B1 (ko) * 2002-10-15 2005-04-20 씨제이 주식회사 이소티아졸 유도체, 그 제조방법 및 약제학적 조성물
RU2475257C1 (ru) * 2011-06-22 2013-02-20 Людмила Николаевна Третьяк Средство для повышения адаптируемости организма к экстремальным условиям

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2297592A1 (fr) * 1993-01-15 1994-07-21 G.D. Searle & Co. Nouveaux thiophenes 3,4-diaryliques et leurs analogues, utiles comme agents anti-inflammatoires
US5436265A (en) * 1993-11-12 1995-07-25 Merck Frosst Canada, Inc. 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
KR100229343B1 (ko) * 1993-11-30 1999-11-01 윌리암스 로저 에이 염증치료용 치환 피라졸일벤젠술폰아미드
US5521213A (en) * 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
JPH10511089A (ja) * 1994-12-21 1998-10-27 メルク フロスト カナダ インコーポレーテツド Ｃｏｘ−２阻害剤としてのジアリール−２−（５ｈ）−フラノン
US5691374A (en) * 1995-05-18 1997-11-25 Merck Frosst Canada Inc. Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHAKRABORTY I. et al. Developmental expression of the cyclo- oxygenase-1 and cyclo-oxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids. J. Mol. Endocrinol. 1996, Apr; 16(2), 107-22. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2472523C2 (ru) * 2006-08-16 2013-01-20 Марлин Ньютрасьютикалз, Инк. Лечение глазных болезней
RU2684315C2 (ru) * 2011-11-01 2019-04-05 Валиркс Плк Медицинское применение

Also Published As

Publication number Publication date
PL194717B1 (pl) 2007-06-29
ID21979A (id) 1999-08-19
SK59999A3 (en) 2000-01-18
WO1998022101A2 (fr) 1998-05-28
PL333370A1 (en) 1999-12-06
NZ335853A (en) 2002-02-01
NO992309L (no) 1999-05-12
RO118566B1 (ro) 2003-07-30
UA70294C2 (en) 2004-10-15
CA2270469C (fr) 2007-04-10
EP0941080A2 (fr) 1999-09-15
CA2270469A1 (fr) 1998-05-28
AU7298298A (en) 1998-06-10
JP2001505564A (ja) 2001-04-24
CN1247470A (zh) 2000-03-15
AU730211B2 (en) 2001-03-01
IL129604A0 (en) 2000-02-29
CZ176899A3 (cs) 1999-10-13
PL191793B1 (pl) 2006-07-31
NO992309D0 (no) 1999-05-12
IL129604A (en) 2004-08-31
BR9713522A (pt) 2000-03-21
TR199901703T2 (xx) 2000-07-21
WO1998022101A3 (fr) 1998-06-25
KR20000053362A (ko) 2000-08-25

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Effective date: 20081120