RU2223969C2 - Способы облегчения нейропатической боли с применением пептидов, являющихся производными просапозина - Google Patents

Способы облегчения нейропатической боли с применением пептидов, являющихся производными просапозина Download PDF

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RU2223969C2
RU2223969C2 RU98118091/04A RU98118091A RU2223969C2 RU 2223969 C2 RU2223969 C2 RU 2223969C2 RU 98118091/04 A RU98118091/04 A RU 98118091/04A RU 98118091 A RU98118091 A RU 98118091A RU 2223969 C2 RU2223969 C2 RU 2223969C2
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seq
prosaposin
peptide
neuropathic pain
active fragment
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Russian (ru)
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RU98118091A (ru
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Джон С. О'БРАЙЕН (US)
Джон С. О'Брайен
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Риджентс оф Дзе Юниверсити оф Калифорния
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU98118091/04A 1996-03-05 1997-03-05 Способы облегчения нейропатической боли с применением пептидов, являющихся производными просапозина RU2223969C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/611,307 1996-03-05
US08/611,307 US6271196B1 (en) 1996-03-05 1996-03-05 Methods of alleviating neuropathic pain using prosaposin-derived peptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2003131695/14A Division RU2266129C2 (ru) 1996-03-05 1997-03-05 Способ воздействия на нейродегенеративное нарушение или нарушение миелинизации

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RU98118091A RU98118091A (ru) 2000-10-20
RU2223969C2 true RU2223969C2 (ru) 2004-02-20

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Family Applications (2)

Application Number Title Priority Date Filing Date
RU98118091/04A RU2223969C2 (ru) 1996-03-05 1997-03-05 Способы облегчения нейропатической боли с применением пептидов, являющихся производными просапозина
RU2003131695/14A RU2266129C2 (ru) 1996-03-05 1997-03-05 Способ воздействия на нейродегенеративное нарушение или нарушение миелинизации

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RU2003131695/14A RU2266129C2 (ru) 1996-03-05 1997-03-05 Способ воздействия на нейродегенеративное нарушение или нарушение миелинизации

Country Status (16)

Country Link
US (2) US6271196B1 (enExample)
EP (1) EP0929569B1 (enExample)
JP (1) JP4138006B2 (enExample)
KR (1) KR100507715B1 (enExample)
AT (1) ATE340187T1 (enExample)
AU (1) AU734566B2 (enExample)
CA (1) CA2248139C (enExample)
CZ (1) CZ297384B6 (enExample)
DE (1) DE69736712T2 (enExample)
IL (1) IL126082A0 (enExample)
NO (1) NO984093L (enExample)
NZ (1) NZ331757A (enExample)
PL (1) PL187917B1 (enExample)
RU (2) RU2223969C2 (enExample)
SK (1) SK122898A3 (enExample)
WO (1) WO1997032895A1 (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571787A (en) * 1993-07-30 1996-11-05 Myelos Corporation Prosaposin as a neurotrophic factor
US6849602B1 (en) * 1996-03-05 2005-02-01 The Regents Of The University Of California Compositions for alleviating neuropathic pain with prosaposin receptor agonists
AU4267297A (en) * 1997-09-11 1998-09-22 Regents Of The University Of California, The Method of alleviating neuropathic pain
EP0979238A4 (en) * 1997-03-05 2000-08-23 Univ California METHOD FOR HEALING NEUROPATHIC PAIN
CA2284105A1 (en) * 1997-03-24 1998-10-01 John S. O'brien Synthetic saposin c-derived neurotrophic peptides
US6458357B1 (en) * 1997-09-09 2002-10-01 Myelos Corporation Retro-inverso neurotrophic and analgesic peptides
JP2001515866A (ja) * 1997-09-09 2001-09-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア プロサポシン受容体アゴニストを利用したアポトーシスの阻害
WO2000012553A1 (en) * 1998-08-28 2000-03-09 Myelos Corporation Cyclic prosaposin-derived peptides and uses thereof
US20020028783A1 (en) * 1999-09-09 2002-03-07 O'brien John S. Method of stimulating prosaposin receptor activity
USRE45976E1 (en) * 1999-02-24 2016-04-19 Tact Ip, Llc Methods of inhibiting the action of TNF for neurological conditions by administering etanercept intrathecally
JP2002544120A (ja) * 1999-03-30 2002-12-24 ミエロスコーポレーション 逆・反転化プロサポシン由来ポリペプチドおよびその使用
US7309687B1 (en) 1999-04-13 2007-12-18 The Kenneth S. Warren Institute, Inc. Methods for treatment and prevention of neuromuscular and muscular conditions by peripherally administered erythropoietin
US7345019B1 (en) 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
AU6540500A (en) * 1999-06-16 2001-01-02 Myelos Corporation Retro-inverso peptides derived from interleukin-6
WO2000077029A1 (en) * 1999-06-16 2000-12-21 Myelos Corporation Retro-inverso peptides derived from leukemia inhibitory factor
WO2000077028A1 (en) * 1999-06-16 2000-12-21 Myelos Corporation Retro-inverso peptides derived from interleukin-3
US7109168B1 (en) 2000-06-16 2006-09-19 Myelos Corporation Retro-inverso peptides derived from leukemia inhibitory factor
US7754688B2 (en) 1999-06-16 2010-07-13 Myelos Corporation Methods of using retro-inverso peptides derived from interleukin-6
US20040170955A1 (en) 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
US20050074747A1 (en) * 2000-09-08 2005-04-07 Wadih Arap Biopanning and rapid analysis of selective interactive ligands (brasil)
US7452964B2 (en) 2001-09-07 2008-11-18 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
US7420030B2 (en) 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
US6531121B2 (en) 2000-12-29 2003-03-11 The Kenneth S. Warren Institute, Inc. Protection and enhancement of erythropoietin-responsive cells, tissues and organs
US20060287240A1 (en) * 2001-03-09 2006-12-21 O'brien John S Method of stimulating prosaposin receptor activity
US20040176290A1 (en) * 2001-07-18 2004-09-09 Renata Pasqualini Anti-angiogenic state in mice and humans with retinal photorecptor cell degeneration
US7671010B2 (en) * 2002-08-30 2010-03-02 The Board Of Regents Of The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
US20040048243A1 (en) * 2001-09-07 2004-03-11 Wadih Arap Methods and compositions for in vitro targeting
US8507445B2 (en) * 2001-09-07 2013-08-13 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
AU2003259846A1 (en) * 2002-08-16 2004-03-03 The General Hospital Corporation Non-invasive functional imaging of peripheral nervous system activation in humans and animals
US7166691B2 (en) * 2002-12-20 2007-01-23 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Saposin C and receptors as targets for treatment of benign and malignant disorders
ES2402096T3 (es) * 2003-03-26 2013-04-26 Evotec International Gmbh Uso de proteínas relacionadas con saposina para prevenir y tratar la obesidad, diabetes y/o síndrome metabólico
CN1777425A (zh) * 2003-03-28 2006-05-24 阿卡蒂亚药品公司 用于疼痛控制的毒蕈碱性m1受体激动剂
CN100366286C (zh) * 2003-04-28 2008-02-06 常州南云科技有限公司 Saposin C-DOPS:一种抗癌新药
US7834147B2 (en) * 2003-04-28 2010-11-16 Childrens Hospital Medical Center Saposin C-DOPS: a novel anti-tumor agent
US9345745B2 (en) * 2005-04-29 2016-05-24 Bo Wang Methods for treating inflammatory disorders and traumatic brain injury using stabilized non-hematopoietic EPO short peptides
EP1736481A1 (en) * 2005-05-13 2006-12-27 Charite Universitätsmedizin-Berlin Erythropoietin variants
RU2317829C2 (ru) * 2005-10-05 2008-02-27 Федеральное государственное учреждение науки "Екатеринбургский медицинский научный центр профилактики и охраны здоровья рабочих промпредприятий" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека Способ лечения мононевропатий верхних конечностей
US7964585B2 (en) * 2006-03-14 2011-06-21 Case Western Reserve University Composition and method of treating peripheral neuropathy
RU2345786C2 (ru) * 2007-02-27 2009-02-10 Андрей Евгеньевич Кульчиков Способ лечения непрерывно-прогредиентных дегенеративных и демиелинизирующих заболеваний
WO2009094172A2 (en) 2008-01-22 2009-07-30 Araim Pharmaceuticals, Inc. Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage
RU2561582C2 (ru) * 2010-11-19 2015-08-27 Российская Федерация в лице Министерства промышленности и торговли Российской Федерации Инъекционная лекарственная форма олигопептидного препарата для лечения рассеянного склероза и способ ее получения
US9327012B2 (en) * 2011-02-23 2016-05-03 Sapporo Medical University Composition for treating, improving, or preventing pain
RU2669692C1 (ru) * 2017-08-14 2018-10-15 Павел Андреевич Канаев Способ получения комплекса биологически активных пептидов обладающих нейротропной активностью
MX2020009829A (es) * 2018-03-23 2021-01-08 Bexion Pharmaceuticals Inc Composiciones farmaceuticas de saposina c y metodos para tratar el cancer.
WO2019183686A1 (en) 2018-03-29 2019-10-03 Lateral IP Pty Ltd Cyclic peptides and uses thereof
CA3176637A1 (en) * 2021-01-09 2022-07-14 Bexion Pharmaceuticals Inc. Methods of reducing neuropathy and neuropathic symptoms and treating cancer

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169764A (en) * 1990-08-08 1992-12-08 Regeneron Pharmaceuticals, Inc. Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
RU2007417C1 (ru) * 1991-06-21 1994-02-15 Российский государственный медицинский университет Способ получения плацентарного протеина
WO1995013823A1 (en) * 1993-11-15 1995-05-26 Celtrix Pharmaceuticals, Inc. Method of treating neurological disorders
RU2037498C1 (ru) * 1989-04-28 1995-06-19 Пфайзер Инк. Способ получения полипептидов
US5534495A (en) * 1993-05-25 1996-07-09 Advanced Peptides And Biotechnology Sciences Treatment of non-HIV neuropathic pain syndromes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7180787A (en) 1986-04-22 1987-10-29 Salk Institute For Biological Studies, The Fibroblast growth factor
US5187151A (en) * 1991-02-12 1993-02-16 Genentech, Inc. Use of binding protein with igf-i as an anabolic growth promoting agent
US5470582A (en) 1992-02-07 1995-11-28 Syntex (U.S.A.) Inc. Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles
US5700909A (en) * 1993-07-30 1997-12-23 The Regents Of The University Of California Prosaposin and cytokine-derived peptides
US5571787A (en) 1993-07-30 1996-11-05 Myelos Corporation Prosaposin as a neurotrophic factor
EP0979238A4 (en) * 1997-03-05 2000-08-23 Univ California METHOD FOR HEALING NEUROPATHIC PAIN
CA2284105A1 (en) * 1997-03-24 1998-10-01 John S. O'brien Synthetic saposin c-derived neurotrophic peptides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2037498C1 (ru) * 1989-04-28 1995-06-19 Пфайзер Инк. Способ получения полипептидов
US5169764A (en) * 1990-08-08 1992-12-08 Regeneron Pharmaceuticals, Inc. Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
RU2007417C1 (ru) * 1991-06-21 1994-02-15 Российский государственный медицинский университет Способ получения плацентарного протеина
US5534495A (en) * 1993-05-25 1996-07-09 Advanced Peptides And Biotechnology Sciences Treatment of non-HIV neuropathic pain syndromes
WO1995013823A1 (en) * 1993-11-15 1995-05-26 Celtrix Pharmaceuticals, Inc. Method of treating neurological disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
O'Brien JS., FASEB J., 1995, May, 9(8), p. 681-685. O'Brien JS., Proc. Natl. Acad. Sci. USA, 1994, Sep. 27, 91(20), p. 9593-9596. *

Also Published As

Publication number Publication date
DE69736712D1 (de) 2006-11-02
JP4138006B2 (ja) 2008-08-20
DE69736712T2 (de) 2007-09-13
KR19990087686A (ko) 1999-12-27
CZ297384B6 (cs) 2006-11-15
US6271196B1 (en) 2001-08-07
NO984093D0 (no) 1998-09-04
CZ283998A3 (cs) 1999-05-12
NO984093L (no) 1998-11-04
RU2266129C2 (ru) 2005-12-20
CA2248139A1 (en) 1997-09-12
NZ331757A (en) 1999-10-28
WO1997032895A1 (en) 1997-09-12
US6268347B1 (en) 2001-07-31
EP0929569B1 (en) 2006-09-20
SK122898A3 (en) 2000-02-14
PL328701A1 (en) 1999-02-15
AU2328697A (en) 1997-09-22
AU734566B2 (en) 2001-06-14
RU2003131695A (ru) 2005-04-10
IL126082A0 (en) 1999-05-09
KR100507715B1 (ko) 2006-05-26
CA2248139C (en) 2004-05-18
EP0929569A4 (en) 2000-08-23
JP2000506853A (ja) 2000-06-06
EP0929569A1 (en) 1999-07-21
ATE340187T1 (de) 2006-10-15
PL187917B1 (pl) 2004-11-30

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