RU2211050C2 - Вакцины с адъювантом ltb - Google Patents
Вакцины с адъювантом ltb Download PDFInfo
- Publication number
- RU2211050C2 RU2211050C2 RU2000116260/14A RU2000116260A RU2211050C2 RU 2211050 C2 RU2211050 C2 RU 2211050C2 RU 2000116260/14 A RU2000116260/14 A RU 2000116260/14A RU 2000116260 A RU2000116260 A RU 2000116260A RU 2211050 C2 RU2211050 C2 RU 2211050C2
- Authority
- RU
- Russia
- Prior art keywords
- immunogen
- ltb
- vaccine
- subunits
- mucous membranes
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 39
- 239000002671 adjuvant Substances 0.000 title claims abstract description 29
- 230000002163 immunogen Effects 0.000 claims abstract description 26
- 210000004400 mucous membrane Anatomy 0.000 claims abstract description 26
- 230000004044 response Effects 0.000 claims abstract description 16
- 229930186900 holotoxin Natural products 0.000 claims abstract description 14
- 230000009885 systemic effect Effects 0.000 claims abstract description 12
- 241000588724 Escherichia coli Species 0.000 claims abstract description 9
- 101710146739 Enterotoxin Proteins 0.000 claims abstract description 8
- 239000000147 enterotoxin Substances 0.000 claims abstract description 8
- 231100000655 enterotoxin Toxicity 0.000 claims abstract description 8
- 230000028993 immune response Effects 0.000 claims abstract description 7
- 108060003951 Immunoglobulin Proteins 0.000 claims abstract description 4
- 102000018358 immunoglobulin Human genes 0.000 claims abstract description 4
- 239000000427 antigen Substances 0.000 claims description 37
- 108091007433 antigens Proteins 0.000 claims description 37
- 102000036639 antigens Human genes 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 12
- 230000002588 toxic effect Effects 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 11
- 206010022000 influenza Diseases 0.000 claims description 11
- 231100000331 toxic Toxicity 0.000 claims description 10
- 230000003053 immunization Effects 0.000 claims description 7
- 238000002649 immunization Methods 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 230000003612 virological effect Effects 0.000 claims description 5
- 230000001580 bacterial effect Effects 0.000 claims description 4
- 108020004511 Recombinant DNA Proteins 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 230000002538 fungal effect Effects 0.000 claims description 2
- 230000016379 mucosal immune response Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 230000006698 induction Effects 0.000 abstract description 10
- 239000003814 drug Substances 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 2
- 101000764294 Homo sapiens Lymphotoxin-beta Proteins 0.000 description 24
- 241000699670 Mus sp. Species 0.000 description 24
- 101710154606 Hemagglutinin Proteins 0.000 description 21
- 102100026894 Lymphotoxin-beta Human genes 0.000 description 21
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 21
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 21
- 101710176177 Protein A56 Proteins 0.000 description 21
- 239000000185 hemagglutinin Substances 0.000 description 21
- 241000700605 Viruses Species 0.000 description 20
- 241000712461 unidentified influenza virus Species 0.000 description 20
- 230000005875 antibody response Effects 0.000 description 19
- 238000002255 vaccination Methods 0.000 description 15
- 102000009016 Cholera Toxin Human genes 0.000 description 9
- 108010049048 Cholera Toxin Proteins 0.000 description 9
- 239000000203 mixture Substances 0.000 description 8
- 210000002966 serum Anatomy 0.000 description 8
- 206010002091 Anaesthesia Diseases 0.000 description 7
- 230000037005 anaesthesia Effects 0.000 description 7
- 210000004072 lung Anatomy 0.000 description 7
- 229940031626 subunit vaccine Drugs 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000001717 pathogenic effect Effects 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 238000002965 ELISA Methods 0.000 description 5
- 230000001571 immunoadjuvant effect Effects 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 230000009385 viral infection Effects 0.000 description 5
- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 4
- 230000002238 attenuated effect Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 210000003928 nasal cavity Anatomy 0.000 description 4
- 210000002345 respiratory system Anatomy 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- 108700012359 toxins Proteins 0.000 description 4
- 108010006232 Neuraminidase Proteins 0.000 description 3
- 102000005348 Neuraminidase Human genes 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 239000012678 infectious agent Substances 0.000 description 3
- 230000002458 infectious effect Effects 0.000 description 3
- 238000007918 intramuscular administration Methods 0.000 description 3
- 230000003389 potentiating effect Effects 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 239000013598 vector Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 238000001712 DNA sequencing Methods 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 2
- 230000007123 defense Effects 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 102000055414 human LTB Human genes 0.000 description 2
- 239000000568 immunological adjuvant Substances 0.000 description 2
- 230000007108 local immune response Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000000693 micelle Substances 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 210000001331 nose Anatomy 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000003248 secreting effect Effects 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 229940126577 synthetic vaccine Drugs 0.000 description 2
- 230000005730 ADP ribosylation Effects 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 241000606161 Chlamydia Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241001288713 Escherichia coli MC1061 Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241000237858 Gastropoda Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 101150018411 LTB gene Proteins 0.000 description 1
- 239000006391 Luria-Bertani Medium Substances 0.000 description 1
- 108010058846 Ovalbumin Proteins 0.000 description 1
- 241001631646 Papillomaviridae Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 102100021696 Syncytin-1 Human genes 0.000 description 1
- 108010008038 Synthetic Vaccines Proteins 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 241001672648 Vieira Species 0.000 description 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 1
- 230000000240 adjuvant effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000013590 bulk material Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 230000000688 enterotoxigenic effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 108060003552 hemocyanin Proteins 0.000 description 1
- 230000008348 humoral response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 229960003971 influenza vaccine Drugs 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000008949 local secretion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002941 microtiter virus yield reduction assay Methods 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- -1 or a syringe Substances 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 210000005000 reproductive tract Anatomy 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000000277 virosome Substances 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97203671A EP0919243A1 (en) | 1997-11-25 | 1997-11-25 | Vaccine containing B subunits of heat-labile enterotoxin (LTB) of Escherichia coli as an adjuvant |
| EP97203671.9 | 1997-11-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2000116260A RU2000116260A (ru) | 2002-06-27 |
| RU2211050C2 true RU2211050C2 (ru) | 2003-08-27 |
Family
ID=8228966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000116260/14A RU2211050C2 (ru) | 1997-11-25 | 1998-11-24 | Вакцины с адъювантом ltb |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6793928B1 (https=) |
| EP (2) | EP0919243A1 (https=) |
| JP (1) | JP4235359B2 (https=) |
| KR (1) | KR100575019B1 (https=) |
| CN (1) | CN1227032C (https=) |
| AT (1) | ATE238809T1 (https=) |
| AU (1) | AU747061C (https=) |
| BR (1) | BR9815413A (https=) |
| CA (1) | CA2311492C (https=) |
| CZ (1) | CZ299770B6 (https=) |
| DE (1) | DE69814177T2 (https=) |
| DK (1) | DK1071456T3 (https=) |
| ES (1) | ES2198089T3 (https=) |
| HU (1) | HU226214B1 (https=) |
| IL (2) | IL135905A0 (https=) |
| NO (1) | NO324690B1 (https=) |
| NZ (1) | NZ504396A (https=) |
| PL (1) | PL190925B1 (https=) |
| PT (1) | PT1071456E (https=) |
| RU (1) | RU2211050C2 (https=) |
| SK (1) | SK284572B6 (https=) |
| TR (1) | TR200001485T2 (https=) |
| UA (1) | UA72199C2 (https=) |
| WO (1) | WO1999026654A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9326174D0 (en) * | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
| AU2003261492B2 (en) * | 1998-05-08 | 2006-09-07 | Trident Pharmaceuticals, Inc. | Vaccine |
| US7914791B1 (en) | 1998-05-08 | 2011-03-29 | Trident Pharmaceuticals, Inc. | Vaccine |
| EA004794B1 (ru) * | 1998-05-08 | 2004-08-26 | Юниверсити Оф Бристоль | Вакцина |
| JP4889175B2 (ja) * | 1999-10-18 | 2012-03-07 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 感染性因子に対する免疫応答を刺激するための組成物および方法 |
| RU2223783C1 (ru) * | 2002-07-05 | 2004-02-20 | Российская медицинская академия последипломного образования | Способ профилактики гриппа и острых респираторных заболеваний у часто болеющих детей |
| IL158140A0 (en) * | 2003-09-25 | 2004-03-28 | Hadasit Med Res Service | Multiepitope polypeptides for cancer immunotherapy |
| WO2005079841A2 (en) * | 2003-12-09 | 2005-09-01 | Iomai Corporation | Gm1 binding deficient exotoxins for use as immunoadjuvants |
| EP1930025B1 (en) | 2005-08-05 | 2013-05-01 | The University of Tokushima | ANTIGEN-AND-DRUG VEHICLE WHICH ENABLES THE CHANGEOVER FROM THE SELECTIVE PRODUCTION OF IgA ANTIBODY TO THE PRODUCTION OF BOTH OF IgA AND IgG ANTIBODIES, AND TRANSNASAL/TRANSMUCOSAL VACCINE USING THE VEHICLE |
| TWI397419B (zh) * | 2006-03-22 | 2013-06-01 | Abbott Biologicals Bv | 病毒顆粒的鼻內或吸入給藥 |
| US9481912B2 (en) | 2006-09-12 | 2016-11-01 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and identifying nucleic acid sequences in biological samples |
| US8084443B2 (en) | 2007-10-01 | 2011-12-27 | Longhorn Vaccines & Diagnostics Llc | Biological specimen collection and transport system and methods of use |
| US8097419B2 (en) | 2006-09-12 | 2012-01-17 | Longhorn Vaccines & Diagnostics Llc | Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009 |
| US8080645B2 (en) | 2007-10-01 | 2011-12-20 | Longhorn Vaccines & Diagnostics Llc | Biological specimen collection/transport compositions and methods |
| US8652782B2 (en) | 2006-09-12 | 2014-02-18 | Longhorn Vaccines & Diagnostics, Llc | Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids |
| CA2664168A1 (en) * | 2006-10-12 | 2008-04-17 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Telomerase reverse transcriptase fusion protein, nucleotides encoding it, and uses thereof |
| US9683256B2 (en) | 2007-10-01 | 2017-06-20 | Longhorn Vaccines And Diagnostics, Llc | Biological specimen collection and transport system |
| US11041215B2 (en) | 2007-08-24 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | PCR ready compositions and methods for detecting and identifying nucleic acid sequences |
| EP2772267B1 (en) | 2007-08-27 | 2016-04-27 | Longhorn Vaccines and Diagnostics, LLC | Immunogenic compositions and methods |
| US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| US11041216B2 (en) | 2007-10-01 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples |
| EP3494989B1 (en) | 2012-01-26 | 2025-07-16 | Longhorn Vaccines and Diagnostics, LLC | Composite antigenic sequences and vaccines |
| EP2865390B1 (en) * | 2012-06-20 | 2019-08-21 | The University of Tokyo | Mucosal immunity-stimulating agent, and oral pharmaceutical composition for treating hpv infection |
| WO2015089707A1 (zh) | 2013-12-16 | 2015-06-25 | 财团法人农业科技研究所 | 生产不耐热肠毒素b亚单位的质粒、方法及其套组 |
| EP3294448A4 (en) | 2015-05-14 | 2018-12-12 | Longhorn Vaccines and Diagnostics, LLC | Rapid methods for the extraction of nucleic acids from biological samples |
| US20210299247A1 (en) * | 2017-11-01 | 2021-09-30 | Merck Sharp & Dohme Corp. | Stable formulations of cytomegalovirus |
| US11338020B2 (en) | 2018-01-09 | 2022-05-24 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| ES3032290T3 (en) | 2018-03-20 | 2025-07-16 | Theriva Biologics Inc | Intestinal alkaline phosphatase formulations |
| US11654184B2 (en) | 2018-03-20 | 2023-05-23 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| JP7660523B2 (ja) | 2019-05-06 | 2025-04-11 | セリバ・バイオロジクス・インコーポレイテッド | アルカリリン酸塩に基づいた癌治療 |
| US12485166B2 (en) | 2020-02-06 | 2025-12-02 | Longhorn Vaccines And Diagnostics, Llc | Vaccines for the treatment and prevention of zoonotic infections |
| TWI811673B (zh) * | 2020-05-08 | 2023-08-11 | 昱厚生技股份有限公司 | 使用免疫調節劑及包含其之疫苗組合物預防或治療冠狀病毒感染之方法 |
| IE20210235A1 (en) | 2020-10-20 | 2023-08-16 | Longhorn Vaccines & Diagnostics Llc | Immunogenic antigens |
| TWI896302B (zh) * | 2024-08-22 | 2025-09-01 | 國立清華大學 | 重組蛋白及其製備方法、包含重組蛋白的疫苗蛋白質佐劑及重組蛋白用於預防呼吸道疾病的用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997002045A1 (en) * | 1995-07-05 | 1997-01-23 | Oratol Limited | Therapeutic agents and autoimmune diseases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH589453A5 (https=) | 1974-01-14 | 1977-07-15 | Sandoz Ag | |
| JP2849632B2 (ja) * | 1988-04-08 | 1999-01-20 | 社団法人北里研究所 | ワクチン製剤 |
| PT92511A (pt) * | 1988-12-07 | 1990-06-29 | Univ Leicester | Processo de preparacao de um hospedeiro transformado e de proteinas de fusao da subunidade b de toxina labil ao calor |
| US5241053A (en) * | 1990-09-05 | 1993-08-31 | Takeda Chemical Industries, Ltd. | Fused proteins comprising glycoprotein gD of HSV-1 and LTB |
-
1997
- 1997-11-25 EP EP97203671A patent/EP0919243A1/en not_active Withdrawn
-
1998
- 1998-11-24 SK SK776-2000A patent/SK284572B6/sk not_active IP Right Cessation
- 1998-11-24 PL PL340635A patent/PL190925B1/pl unknown
- 1998-11-24 WO PCT/EP1998/007553 patent/WO1999026654A1/en not_active Ceased
- 1998-11-24 DE DE69814177T patent/DE69814177T2/de not_active Expired - Lifetime
- 1998-11-24 KR KR1020007005665A patent/KR100575019B1/ko not_active Expired - Fee Related
- 1998-11-24 JP JP2000521855A patent/JP4235359B2/ja not_active Expired - Fee Related
- 1998-11-24 EP EP98963503A patent/EP1071456B1/en not_active Expired - Lifetime
- 1998-11-24 ES ES98963503T patent/ES2198089T3/es not_active Expired - Lifetime
- 1998-11-24 RU RU2000116260/14A patent/RU2211050C2/ru not_active IP Right Cessation
- 1998-11-24 AT AT98963503T patent/ATE238809T1/de active
- 1998-11-24 DK DK98963503T patent/DK1071456T3/da active
- 1998-11-24 AU AU18750/99A patent/AU747061C/en not_active Ceased
- 1998-11-24 CN CNB988115492A patent/CN1227032C/zh not_active Expired - Fee Related
- 1998-11-24 NZ NZ504396A patent/NZ504396A/en not_active IP Right Cessation
- 1998-11-24 TR TR2000/01485T patent/TR200001485T2/xx unknown
- 1998-11-24 BR BR9815413-3A patent/BR9815413A/pt not_active IP Right Cessation
- 1998-11-24 HU HU0100058A patent/HU226214B1/hu not_active IP Right Cessation
- 1998-11-24 US US09/555,139 patent/US6793928B1/en not_active Expired - Fee Related
- 1998-11-24 CZ CZ20001895A patent/CZ299770B6/cs not_active IP Right Cessation
- 1998-11-24 CA CA2311492A patent/CA2311492C/en not_active Expired - Fee Related
- 1998-11-24 PT PT98963503T patent/PT1071456E/pt unknown
- 1998-11-24 UA UA2000063620A patent/UA72199C2/uk unknown
- 1998-11-24 IL IL13590598A patent/IL135905A0/xx active IP Right Grant
-
2000
- 2000-05-01 IL IL135905A patent/IL135905A/en not_active IP Right Cessation
- 2000-05-22 NO NO20002613A patent/NO324690B1/no not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997002045A1 (en) * | 1995-07-05 | 1997-01-23 | Oratol Limited | Therapeutic agents and autoimmune diseases |
Non-Patent Citations (1)
| Title |
|---|
| HASHIGUCCI, KAZUHIRO et al. Antibody responses in volunteres induced by nasal influenza vaccine combined with Echerichia coli heat-labile enterotoxin B subunit containing a trace amount of the holotoxin. Vaccine. - 1996, v.14, №2, рр.113-119. TAMURA, SHINICHI et al. Esherichia coli heat-labile enterotoxin B subunits supplemented with a trace amount of the holotoxin as an adjuvant for nasal influenza vaccine. - Vaccine, 1994, v.12, №12, рр.1083-1089. * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2211050C2 (ru) | Вакцины с адъювантом ltb | |
| US8182821B2 (en) | Flu vaccine admixture of mannan and flu antigen | |
| Tamura et al. | Enhancement of protective antibody responses by cholera toxin B subunit inoculated intranasally with influenza vaccine | |
| US20100255033A1 (en) | Non-toxic double mutant forms of pertussis toxin as adjuvants | |
| US6129922A (en) | Methods for adjuvant free hepatitis A virus vaccination | |
| EP0721782B1 (en) | Influenza vaccine containing pertussis toxin | |
| EP1282640A2 (en) | Nucleic acid immunization | |
| WO2008037033A1 (en) | Flu vaccine admixture of mannan and flu antigen | |
| HK1031102B (en) | Vaccines with an ltb adjuvant | |
| MXPA00005127A (en) | Vaccines with an ltb adjuvant | |
| WO1992002250A1 (en) | Cross-reactive influenza a immunization | |
| WO1994022917A1 (en) | Cross-reactive influenza a immunization |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC4A | Invention patent assignment |
Effective date: 20100728 |
|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20131125 |