BR9815413A - Vacina, processos para indução de uma resposta sistêmica de imunoglobulina contra um imunógeno e de uma resposta imune mucosal comum contra um imunógeno, e, uso de subunidades b de enterotoxina - Google Patents

Vacina, processos para indução de uma resposta sistêmica de imunoglobulina contra um imunógeno e de uma resposta imune mucosal comum contra um imunógeno, e, uso de subunidades b de enterotoxina

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Publication number
BR9815413A
BR9815413A BR9815413-3A BR9815413A BR9815413A BR 9815413 A BR9815413 A BR 9815413A BR 9815413 A BR9815413 A BR 9815413A BR 9815413 A BR9815413 A BR 9815413A
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BR
Brazil
Prior art keywords
response against
immunogen
vaccine
inducing
enterotoxin
Prior art date
Application number
BR9815413-3A
Other languages
English (en)
Inventor
Rudi Brands
Willem Ronald Verweij
Etienne Agsteribbe
Haan Lolke De
Jan Christiaan Wilschut
Scharrenburg Gustaaf Johan Van
Original Assignee
Duphar Int Res
Universiteit Van Groningen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res, Universiteit Van Groningen filed Critical Duphar Int Res
Publication of BR9815413A publication Critical patent/BR9815413A/pt

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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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Abstract

"VACINA PARA ADMINISTRAçãO MUCOSAL, PROCESSOS PARA INDUçãO DE UMA RESPOSTA SISTêMICA DE IMUNOGLOBULINA CONTRA UM IMUNóGENO E DE UMA RESPOSTA IMUNE MUCOSAL COMUM CONTRA UM IMUNóGENO, E, USO DE SUBUNIDADES B DE ENTEROTOXINA". A presente invenção refere-se a uma vacina contendo pelo menos um imunógeno particulado e uma quantidade de adjuvante de subunidades B de enterotoxina lábil pelo calor característica de E. coli. Mais especificamente, esta invenção refere-se às vacinas nas quais o adjuvante LTB está livre de subunidades A contaminantes ou holotoxina. Para este fim, de preferência, é usado LTB preparada por técnicas de DNA recombinante. Os imunógenos particulados podem referir-se a, ou serem derivados de, por exemplo vírus, bactérias ou fungos. Esta vacina é particularmente adequada para a indução de uma resposta positiva contra citado imunógeno particulado por administração mucosal (por exemplo, intra-nasal). Foi verificado que tal administração resulta em proteção tanto sistêmica quanto mucosal contra o patógeno ao qual relaciona-se o imunógeno particulado.
BR9815413-3A 1997-11-25 1998-11-24 Vacina, processos para indução de uma resposta sistêmica de imunoglobulina contra um imunógeno e de uma resposta imune mucosal comum contra um imunógeno, e, uso de subunidades b de enterotoxina BR9815413A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97203671A EP0919243A1 (en) 1997-11-25 1997-11-25 Vaccine containing B subunits of heat-labile enterotoxin (LTB) of Escherichia coli as an adjuvant
PCT/EP1998/007553 WO1999026654A1 (en) 1997-11-25 1998-11-24 Vaccines with an ltb adjuvant

Publications (1)

Publication Number Publication Date
BR9815413A true BR9815413A (pt) 2000-10-17

Family

ID=8228966

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9815413-3A BR9815413A (pt) 1997-11-25 1998-11-24 Vacina, processos para indução de uma resposta sistêmica de imunoglobulina contra um imunógeno e de uma resposta imune mucosal comum contra um imunógeno, e, uso de subunidades b de enterotoxina

Country Status (25)

Country Link
US (1) US6793928B1 (pt)
EP (2) EP0919243A1 (pt)
JP (1) JP4235359B2 (pt)
KR (1) KR100575019B1 (pt)
CN (1) CN1227032C (pt)
AT (1) ATE238809T1 (pt)
AU (1) AU747061C (pt)
BR (1) BR9815413A (pt)
CA (1) CA2311492C (pt)
CZ (1) CZ299770B6 (pt)
DE (1) DE69814177T2 (pt)
DK (1) DK1071456T3 (pt)
ES (1) ES2198089T3 (pt)
HK (1) HK1031102A1 (pt)
HU (1) HU226214B1 (pt)
IL (2) IL135905A0 (pt)
NO (1) NO324690B1 (pt)
NZ (1) NZ504396A (pt)
PL (1) PL190925B1 (pt)
PT (1) PT1071456E (pt)
RU (1) RU2211050C2 (pt)
SK (1) SK284572B6 (pt)
TR (1) TR200001485T2 (pt)
UA (1) UA72199C2 (pt)
WO (1) WO1999026654A1 (pt)

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US7914791B1 (en) 1998-05-08 2011-03-29 Trident Pharmaceuticals, Inc. Vaccine
AU2003261492B2 (en) * 1998-05-08 2006-09-07 Trident Pharmaceuticals, Inc. Vaccine
EP1075274A2 (en) * 1998-05-08 2001-02-14 University Of Bristol Immunomodulators for vaccines
JP4889175B2 (ja) * 1999-10-18 2012-03-07 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 感染性因子に対する免疫応答を刺激するための組成物および方法
IL158140A0 (en) * 2003-09-25 2004-03-28 Hadasit Med Res Service Multiepitope polypeptides for cancer immunotherapy
US20060002960A1 (en) * 2003-12-09 2006-01-05 Paul Zoeteweij GM1 binding deficient exotoxins for use as immunoadjuvants
CN101257919B (zh) 2005-08-05 2012-08-29 国立大学法人德岛大学 可以由选择性产生IgA抗体向产生IgA和IgG两种抗体转换的抗原药物载体和使用该载体的经鼻·粘膜疫苗
TWI397419B (zh) * 2006-03-22 2013-06-01 Abbott Biologicals Bv 病毒顆粒的鼻內或吸入給藥
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US8652782B2 (en) 2006-09-12 2014-02-18 Longhorn Vaccines & Diagnostics, Llc Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
US9481912B2 (en) 2006-09-12 2016-11-01 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and identifying nucleic acid sequences in biological samples
ES2376010T3 (es) 2006-10-12 2012-03-08 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L. Prote�?na de fusión de transcriptasa inversa de la telomerasa, nucleótidos que la codifican y usos de la misma.
US9683256B2 (en) 2007-10-01 2017-06-20 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system
US11041215B2 (en) 2007-08-24 2021-06-22 Longhorn Vaccines And Diagnostics, Llc PCR ready compositions and methods for detecting and identifying nucleic acid sequences
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RU2468034C2 (ru) 2007-08-27 2012-11-27 ЛОНГХОРН ВЭКСИНС ЭНД ДИАГНОСТИКС ЭлЭлСи Иммуногенные композиции и способы
US11041216B2 (en) 2007-10-01 2021-06-22 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples
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CA3207612A1 (en) 2012-01-26 2013-08-01 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
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WO2015089707A1 (zh) 2013-12-16 2015-06-25 财团法人农业科技研究所 生产不耐热肠毒素b亚单位的质粒、方法及其套组
WO2016183292A1 (en) 2015-05-14 2016-11-17 Longhorn Vaccines And Diagnostics, Llc Rapid methods for the extraction of nucleic acids from biological samples
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Also Published As

Publication number Publication date
HUP0100058A1 (hu) 2001-05-28
RU2211050C2 (ru) 2003-08-27
US6793928B1 (en) 2004-09-21
PT1071456E (pt) 2003-09-30
KR20010032425A (ko) 2001-04-16
EP0919243A1 (en) 1999-06-02
ATE238809T1 (de) 2003-05-15
IL135905A0 (en) 2001-05-20
CA2311492C (en) 2011-10-18
AU1875099A (en) 1999-06-15
PL190925B1 (pl) 2006-02-28
AU747061B2 (en) 2002-05-09
EP1071456A1 (en) 2001-01-31
DK1071456T3 (da) 2003-06-02
JP4235359B2 (ja) 2009-03-11
NZ504396A (en) 2002-09-27
PL340635A1 (en) 2001-02-12
HK1031102A1 (en) 2001-06-01
SK284572B6 (sk) 2005-06-02
NO20002613L (no) 2000-05-22
TR200001485T2 (tr) 2001-12-21
KR100575019B1 (ko) 2006-05-02
HUP0100058A3 (en) 2003-03-28
HU226214B1 (en) 2008-06-30
EP1071456B1 (en) 2003-05-02
CZ299770B6 (cs) 2008-11-19
CA2311492A1 (en) 1999-06-03
NO324690B1 (no) 2007-12-03
CN1227032C (zh) 2005-11-16
IL135905A (en) 2006-08-01
SK7762000A3 (en) 2000-11-07
WO1999026654A1 (en) 1999-06-03
CN1280504A (zh) 2001-01-17
NO20002613D0 (no) 2000-05-22
JP2001523729A (ja) 2001-11-27
DE69814177D1 (de) 2003-06-05
DE69814177T2 (de) 2004-04-08
UA72199C2 (en) 2005-02-15
ES2198089T3 (es) 2004-01-16
AU747061C (en) 2005-02-24
CZ20001895A3 (cs) 2000-10-11

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ART. 37, OPINO PELO INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE NAO ATENDE AO REQUISITO DE ATIVIDADE INVENTIVA ( ART. 8O COMBINADO COM O ART. 13 DA LPI 9279/96).

B25A Requested transfer of rights approved

Owner name: UNIVERSITEIT VAN GRONINGEN (NL) , SOLVAY BIOLOGICA

Free format text: TRANSFERIDO DE : DUPHAR INTERNATIONAL RESEARCH BV.

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