RU2200166C2 - Производные циклопептидов в качестве ингибиторов адгезии - Google Patents
Производные циклопептидов в качестве ингибиторов адгезии Download PDFInfo
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- RU2200166C2 RU2200166C2 RU2000107122/04A RU2000107122A RU2200166C2 RU 2200166 C2 RU2200166 C2 RU 2200166C2 RU 2000107122/04 A RU2000107122/04 A RU 2000107122/04A RU 2000107122 A RU2000107122 A RU 2000107122A RU 2200166 C2 RU2200166 C2 RU 2200166C2
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- PEECTLLHENGOKU-UHFFFAOYSA-N n,n-dimethylpyridin-4-amine Chemical compound CN(C)C1=CC=NC=C1.CN(C)C1=CC=NC=C1 PEECTLLHENGOKU-UHFFFAOYSA-N 0.000 description 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 description 1
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- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical class OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
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- 229940002612 prodrug Drugs 0.000 description 1
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- NSETWVJZUWGCKE-UHFFFAOYSA-N propylphosphonic acid Chemical compound CCCP(O)(O)=O NSETWVJZUWGCKE-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- 238000002560 therapeutic procedure Methods 0.000 description 1
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- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19736772A DE19736772A1 (de) | 1997-08-23 | 1997-08-23 | Cyclopeptidderivate |
| DE19736772.0 | 1997-08-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2000107122A RU2000107122A (ru) | 2002-01-10 |
| RU2200166C2 true RU2200166C2 (ru) | 2003-03-10 |
Family
ID=7839977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000107122/04A RU2200166C2 (ru) | 1997-08-23 | 1998-08-14 | Производные циклопептидов в качестве ингибиторов адгезии |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1007545A2 (de) |
| JP (1) | JP2001514186A (de) |
| KR (1) | KR20010022828A (de) |
| CN (1) | CN1267306A (de) |
| AR (1) | AR013650A1 (de) |
| AU (1) | AU734829B2 (de) |
| BR (1) | BR9811992A (de) |
| CA (1) | CA2301182A1 (de) |
| DE (1) | DE19736772A1 (de) |
| HU (1) | HUP0003500A3 (de) |
| ID (1) | ID23952A (de) |
| NO (1) | NO20000860D0 (de) |
| PL (1) | PL341090A1 (de) |
| RU (1) | RU2200166C2 (de) |
| SK (1) | SK2132000A3 (de) |
| TW (1) | TW477793B (de) |
| WO (1) | WO1999010371A2 (de) |
| ZA (1) | ZA987558B (de) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU95118183A (ru) * | 1993-03-30 | 1997-10-20 | Е.И.Дю Пон Мерк Фармацьютикал Компани | Радиоактивномеченые антагонисты gpiib/iiiа-рецептора тромбоцитов как создающие изображение соединения для диагностики тромбоэмболических заболеваний |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA43823C2 (uk) * | 1992-07-06 | 2002-01-15 | Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг | ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН |
| US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| DE4310643A1 (de) * | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| DE4415310A1 (de) * | 1994-04-30 | 1995-11-02 | Merck Patent Gmbh | Cyclopeptide |
| JPH07316193A (ja) * | 1994-05-24 | 1995-12-05 | Asahi Glass Co Ltd | ペプチド誘導体およびその用途 |
-
1997
- 1997-08-23 DE DE19736772A patent/DE19736772A1/de not_active Withdrawn
-
1998
- 1998-08-14 KR KR1020007001430A patent/KR20010022828A/ko not_active Withdrawn
- 1998-08-14 JP JP2000507697A patent/JP2001514186A/ja active Pending
- 1998-08-14 CN CN98808380A patent/CN1267306A/zh active Pending
- 1998-08-14 HU HU0003500A patent/HUP0003500A3/hu unknown
- 1998-08-14 BR BR9811992-3A patent/BR9811992A/pt not_active IP Right Cessation
- 1998-08-14 SK SK213-2000A patent/SK2132000A3/sk unknown
- 1998-08-14 AU AU95319/98A patent/AU734829B2/en not_active Ceased
- 1998-08-14 WO PCT/EP1998/005161 patent/WO1999010371A2/de not_active Ceased
- 1998-08-14 RU RU2000107122/04A patent/RU2200166C2/ru not_active IP Right Cessation
- 1998-08-14 CA CA002301182A patent/CA2301182A1/en not_active Abandoned
- 1998-08-14 PL PL98341090A patent/PL341090A1/xx unknown
- 1998-08-14 ID IDW20000532A patent/ID23952A/id unknown
- 1998-08-14 EP EP98948833A patent/EP1007545A2/de not_active Withdrawn
- 1998-08-19 TW TW087113657A patent/TW477793B/zh not_active IP Right Cessation
- 1998-08-20 ZA ZA987558A patent/ZA987558B/xx unknown
- 1998-08-21 AR ARP980104136A patent/AR013650A1/es not_active Application Discontinuation
-
2000
- 2000-02-22 NO NO20000860A patent/NO20000860D0/no unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU95118183A (ru) * | 1993-03-30 | 1997-10-20 | Е.И.Дю Пон Мерк Фармацьютикал Компани | Радиоактивномеченые антагонисты gpiib/iiiа-рецептора тромбоцитов как создающие изображение соединения для диагностики тромбоэмболических заболеваний |
Also Published As
| Publication number | Publication date |
|---|---|
| NO20000860L (no) | 2000-02-22 |
| AU9531998A (en) | 1999-03-16 |
| AU734829B2 (en) | 2001-06-21 |
| KR20010022828A (ko) | 2001-03-26 |
| CN1267306A (zh) | 2000-09-20 |
| ID23952A (id) | 2000-06-08 |
| WO1999010371A3 (de) | 1999-05-27 |
| DE19736772A1 (de) | 1999-02-25 |
| WO1999010371A2 (de) | 1999-03-04 |
| SK2132000A3 (en) | 2000-09-12 |
| CA2301182A1 (en) | 1999-03-04 |
| HUP0003500A2 (hu) | 2001-02-28 |
| JP2001514186A (ja) | 2001-09-11 |
| TW477793B (en) | 2002-03-01 |
| BR9811992A (pt) | 2000-09-05 |
| PL341090A1 (en) | 2001-03-26 |
| NO20000860D0 (no) | 2000-02-22 |
| EP1007545A2 (de) | 2000-06-14 |
| AR013650A1 (es) | 2001-01-10 |
| HUP0003500A3 (en) | 2001-12-28 |
| ZA987558B (en) | 1999-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20030815 |