RU2198176C2 - Способы получения производных азостероидов, производное азостероид-имидазолида, способ его получения - Google Patents

Способы получения производных азостероидов, производное азостероид-имидазолида, способ его получения Download PDF

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Publication number
RU2198176C2
RU2198176C2 RU99120995/04A RU99120995A RU2198176C2 RU 2198176 C2 RU2198176 C2 RU 2198176C2 RU 99120995/04 A RU99120995/04 A RU 99120995/04A RU 99120995 A RU99120995 A RU 99120995A RU 2198176 C2 RU2198176 C2 RU 2198176C2
Authority
RU
Russia
Prior art keywords
formula
derivative
azosteroid
oxo
carboxamide
Prior art date
Application number
RU99120995/04A
Other languages
English (en)
Russian (ru)
Other versions
RU99120995A (ru
Inventor
Акилле Панцери
Маттео Д'анелло
Антонио Лонго
Марчелла НЕСИ
Original Assignee
Фармация Энд Апджон Спа
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон Спа filed Critical Фармация Энд Апджон Спа
Publication of RU99120995A publication Critical patent/RU99120995A/ru
Application granted granted Critical
Publication of RU2198176C2 publication Critical patent/RU2198176C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU99120995/04A 1997-12-31 1998-12-17 Способы получения производных азостероидов, производное азостероид-имидазолида, способ его получения RU2198176C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9727522.6 1997-12-31
GBGB9727522.6A GB9727522D0 (en) 1997-12-31 1997-12-31 Process for preparing carboxamido-4-azasteroids

Publications (2)

Publication Number Publication Date
RU99120995A RU99120995A (ru) 2001-06-27
RU2198176C2 true RU2198176C2 (ru) 2003-02-10

Family

ID=10824341

Family Applications (1)

Application Number Title Priority Date Filing Date
RU99120995/04A RU2198176C2 (ru) 1997-12-31 1998-12-17 Способы получения производных азостероидов, производное азостероид-имидазолида, способ его получения

Country Status (19)

Country Link
US (2) US6121449A (no)
EP (1) EP0970105B1 (no)
JP (1) JP2001515518A (no)
KR (1) KR20000075845A (no)
CN (1) CN1248263A (no)
AT (1) ATE213741T1 (no)
AU (1) AU753602B2 (no)
CA (1) CA2278487A1 (no)
DE (1) DE69803979T2 (no)
DK (1) DK0970105T3 (no)
ES (1) ES2173675T3 (no)
GB (1) GB9727522D0 (no)
HU (1) HUP0001444A3 (no)
NO (1) NO312195B1 (no)
PT (1) PT970105E (no)
RU (1) RU2198176C2 (no)
TW (1) TW442491B (no)
WO (1) WO1999035161A1 (no)
ZA (1) ZA9811950B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001844A (en) 1995-09-15 1999-12-14 Merck & Co., Inc. 4-Azasteroids for treatment of hyperandrogenic conditions
US6645974B2 (en) 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
WO2005004807A2 (en) * 2003-06-30 2005-01-20 Merck & Co., Inc. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
US7482357B2 (en) 2003-06-30 2009-01-27 Merck & Co., Inc. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
JP2007521293A (ja) * 2003-06-30 2007-08-02 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体モジュレータとしての１７−アセトアミド−４−アザステロイド誘導体
CN100528168C (zh) * 2003-06-30 2009-08-19 麦克公司 作为雄激素受体调节剂的17-乙酰氨基-4-氮杂甾类衍生物
AU2004272004B2 (en) * 2003-09-10 2009-01-22 Merck Sharp & Dohme Corp. 17-heterocyclic-4-azasteroid derivatives as androgen receptor modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
GB9115676D0 (en) * 1991-07-19 1991-09-04 Erba Carlo Spa Process for the preparation of 17 beta substituted-4-aza-5 alpha-androstan-3-one derivatives
GB9216329D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives
GB9415178D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 4-azasteroids with side-chain fluoroketones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ТРИНУС Ф.П. Фармако-терапевтический справочник. - Киев: Здоровья, 1989, с.263. RASMUSSONGH et al. AZASTEROIDS structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding. J. of Med. Сhеm. V.29, № 11, 1986, p.2298-2315. *

Also Published As

Publication number Publication date
HUP0001444A2 (hu) 2000-11-28
US6284887B1 (en) 2001-09-04
ATE213741T1 (de) 2002-03-15
WO1999035161A1 (en) 1999-07-15
HUP0001444A3 (en) 2001-03-28
PT970105E (pt) 2002-07-31
NO312195B1 (no) 2002-04-08
DK0970105T3 (da) 2002-05-27
NO994199D0 (no) 1999-08-30
CA2278487A1 (en) 1999-07-15
DE69803979D1 (de) 2002-04-04
US6121449A (en) 2000-09-19
DE69803979T2 (de) 2003-02-06
ES2173675T3 (es) 2002-10-16
GB9727522D0 (en) 1998-02-25
JP2001515518A (ja) 2001-09-18
NO994199L (no) 1999-10-29
TW442491B (en) 2001-06-23
EP0970105B1 (en) 2002-02-27
AU753602B2 (en) 2002-10-24
CN1248263A (zh) 2000-03-22
AU2514699A (en) 1999-07-26
KR20000075845A (ko) 2000-12-26
EP0970105A1 (en) 2000-01-12
ZA9811950B (en) 1999-06-30

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20051218