RU2195312C2 - СПОСОБЫ И КОМПОЗИЦИИ, ИСПОЛЬЗУЕМЫЕ ДЛЯ ИНГИБИРОВАНИЯ αvβ5-ОПОСРЕДОВАННОГО АНГИОГЕНЕЗА - Google Patents

СПОСОБЫ И КОМПОЗИЦИИ, ИСПОЛЬЗУЕМЫЕ ДЛЯ ИНГИБИРОВАНИЯ αvβ5-ОПОСРЕДОВАННОГО АНГИОГЕНЕЗА Download PDF

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RU2195312C2
RU2195312C2 RU98123834/14A RU98123834A RU2195312C2 RU 2195312 C2 RU2195312 C2 RU 2195312C2 RU 98123834/14 A RU98123834/14 A RU 98123834/14A RU 98123834 A RU98123834 A RU 98123834A RU 2195312 C2 RU2195312 C2 RU 2195312C2
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angiogenesis
tissue
antagonist
compound
tumor
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RU98123834A (ru
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Питер Брукс
Дэвид А. Череш
Мартин Фридлэндер
Стивен СИЛЛЕТТИ
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Дзе Скриппс Рисерч Инститьют
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    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
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    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
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RU98123834/14A 1996-05-31 1997-05-30 СПОСОБЫ И КОМПОЗИЦИИ, ИСПОЛЬЗУЕМЫЕ ДЛЯ ИНГИБИРОВАНИЯ αvβ5-ОПОСРЕДОВАННОГО АНГИОГЕНЕЗА RU2195312C2 (ru)

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US1877396P 1996-05-31 1996-05-31
US1586996P 1996-05-31 1996-05-31
US60/015,869 1996-05-31
US60/018,773 1996-05-31

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RU98123834A RU98123834A (ru) 2000-10-27
RU2195312C2 true RU2195312C2 (ru) 2002-12-27

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RU98123834/14A RU2195312C2 (ru) 1996-05-31 1997-05-30 СПОСОБЫ И КОМПОЗИЦИИ, ИСПОЛЬЗУЕМЫЕ ДЛЯ ИНГИБИРОВАНИЯ αvβ5-ОПОСРЕДОВАННОГО АНГИОГЕНЕЗА
RU98123833/14A RU2194528C2 (ru) 1996-05-31 1997-05-30 Способы и композиции, используемые для ингибирования ангиогенеза

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US (1) US6500924B1 (enExample)
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2361614C2 (ru) * 2004-03-24 2009-07-20 ПиДиЭл БАЙОФАРМА, ИНК. ПРИМЕНЕНИЕ АНТИТЕЛ ПРОТИВ α5β1 ДЛЯ ИНГИБИРОВАНИЯ ПРОЛИФЕРАЦИИ РАКОВЫХ КЛЕТОК
RU2365382C2 (ru) * 2004-04-14 2009-08-27 Дженентек, Инк. Композиции и способы для регуляции развития сосудов
RU2401124C2 (ru) * 2005-02-24 2010-10-10 Дзе Скриппс Рисерч Инститьют Реваскуляризация ишемической ткани сетчатки и способ ее скрининга
RU2417099C2 (ru) * 2005-11-04 2011-04-27 Дженентек, Инк. Применение ингибиторов пути комплемента для лечения глазных болезней
RU2434640C2 (ru) * 2006-02-09 2011-11-27 Микромет Аг Лечение метастатического рака молочной железы
RU2600794C2 (ru) * 2010-10-07 2016-10-27 Аэрпио Терапьютикс, Инк. Композиции и способы лечения глазного отека, неоваскуляризации и связанных с ними заболеваний

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053041B1 (en) * 1996-05-31 2006-05-30 The Scripps Research Institute Methods and compositions useful for inhibition of αvβ5mediated angiogenesis
CA2227265C (en) * 1995-08-14 2012-01-03 The Scripps Research Institute Methods and compositions useful for inhibition of .alpha.v.beta.5 mediated angiogenesis
US20040063790A1 (en) * 1996-05-31 2004-04-01 The Scripps Research Institute Methods for inhibition of angiogenesis
US20050281821A1 (en) * 1999-01-06 2005-12-22 Flavia Pernasetti Method and composition for angiogenesis inhibition
US6790930B1 (en) * 1999-10-06 2004-09-14 Kaneka Corporation Process for producing polyimide resin
KR20030080013A (ko) * 2001-02-21 2003-10-10 에자이 가부시키가이샤 인테그린 발현 억제를 통한 혈관 신생 억제제의 효과를검정하는 방법
US7019108B2 (en) * 2001-06-01 2006-03-28 University Of Southern California Method and composition for inhibition of angiogenesis and tumor growth using compounds based on a sequence within MMP-2
AU2002319282B2 (en) * 2001-08-01 2007-06-28 Merck Patent Gmbh Integrin inhibitors for the treatment of eye diseases
US7301006B2 (en) * 2002-07-16 2007-11-27 Wisconsin Alumni Research Foundation Methods and materials for the synthesis of modified peptides
FR2856598B1 (fr) * 2003-06-25 2005-10-28 Inst Nat Sante Rech Med Peptides derives de la proteine mmp-2 et leur utilisation en immunotherapie antitumorale
WO2005090406A2 (en) 2004-03-12 2005-09-29 Vasgene Therapeutics, Inc. Antibodies binding to ephb4 for inhibiting angiogenesis and tumor growth
US7973134B2 (en) * 2004-07-07 2011-07-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
WO2006034455A2 (en) 2004-09-23 2006-03-30 Vasgene Therapeutics, Inc. Polipeptide compounds for inhibiting angiogenesis and tumor growth
US7935790B2 (en) * 2004-10-04 2011-05-03 Cell Singaling Technology, Inc. Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways
US7807789B2 (en) * 2004-12-21 2010-10-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
WO2006072563A2 (en) * 2005-01-03 2006-07-13 F. Hoffmann-La Roche Ag Hemopexin-like structure as polypeptide-scaffold
US20090099340A1 (en) * 2007-10-12 2009-04-16 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
US20060286148A1 (en) * 2005-05-18 2006-12-21 Ppd, Inc. Method of forming implants
CA2619654A1 (en) * 2005-08-24 2007-03-01 Cell Matrix Combination therapies for inhibiting integrin-extracellular matrix interactions
US20100151495A9 (en) * 2005-08-31 2010-06-17 Cell Signaling Technolgy, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
WO2007027906A2 (en) * 2005-08-31 2007-03-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
US20080289578A1 (en) * 2005-09-20 2008-11-27 Rybarczyk Jr Phillip L Methods for Rapidly and Accurately Locating Avian Egg Blastoderms
EP2463305B1 (en) 2006-01-12 2016-05-11 Alexion Pharmaceuticals, Inc. Antibodies to OX-2/CD200 and uses thereof
WO2007127335A2 (en) * 2006-04-27 2007-11-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in atm and atr kinase signaling pathways
EP1862541A1 (en) * 2006-06-01 2007-12-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Polypeptides derived from the hemopexin-like domain of metalloproteinase MMP-2
US7939636B2 (en) * 2006-08-11 2011-05-10 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in c-Src signaling pathways
US20090258442A1 (en) * 2006-08-31 2009-10-15 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
TWI584815B (zh) 2007-02-01 2017-06-01 艾瑟勒朗法瑪公司 活化素-ActRIIa拮抗劑及其治療或預防乳癌之用途
US20090081659A1 (en) 2007-03-07 2009-03-26 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
EP1975184A3 (en) 2007-03-26 2008-11-26 Cell Signaling Technology, Inc. Serine or threonine phosphorylation sites
US20080238709A1 (en) * 2007-03-28 2008-10-02 Faramarz Vaziri One-way communication apparatus with dynamic key generation
US7977462B2 (en) 2007-04-19 2011-07-12 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
EP1983003A3 (en) 2007-04-19 2009-03-11 Peter Hornbeck Tyrosine phosphorylation sites and antibodies specific for them
EP2145902A3 (en) 2007-04-19 2010-09-29 Peter Hornbeck Tyrosine phosphorylation sites and antibodies specific for them
US20090053831A1 (en) 2007-05-01 2009-02-26 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
CA2699936A1 (en) 2007-09-18 2009-03-26 Acceleron Pharma Inc. Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion
US20090203043A1 (en) 2007-11-21 2009-08-13 Peter Hornbeck Protein phosphorylation by basophilic serine/threonine kinases in insulin signaling pathways
US20090220991A1 (en) * 2008-02-29 2009-09-03 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
BR112012011731A2 (pt) 2009-11-10 2020-08-25 Allegro Pharmaceuticals, Inc. composições e métodos para inibir a adesão celular ou direcionamento dos agentes de diagnóstico ou terapêuticos para os sítios de ligação rgd
US11673914B2 (en) 2009-11-10 2023-06-13 Allegro Pharmaceuticals, LLC Peptide therapies for reduction of macular thickening
RU2429836C1 (ru) * 2010-04-01 2011-09-27 Максуд Мухамеджанович Расулов СРЕДСТВО, СТИМУЛИРУЮЩЕЕ ЭКСПРЕССИЮ МАТРИЧНОЙ РНК ТРИПТОФАНИЛ-тРНК-СИНТЕТАЗЫ
ES2820855T3 (es) 2011-05-09 2021-04-22 Allegro Pharmaceuticals Llc Antagonistas del receptor de integrina y sus métodos de uso
HK1206610A1 (en) 2012-03-30 2016-01-15 Sorrento Therapeutics, Inc. Fully human antibodies that bind to vegfr2
EP4026849A1 (en) 2016-09-26 2022-07-13 Ensemble Group Holdings Methods of assessing and treating cancer in subjects having dysregulated lymphatic systems using a combination of vegfr-3 and pd-1 or pd-l1 inhibitors
US20200109205A1 (en) * 2017-03-31 2020-04-09 The Regents Of The University Of California Compositions and methods for targeting and killing alpha-v beta-3-positive cancer stem cells (cscs) and treating drug resistant cancers
CN113663929A (zh) * 2021-09-24 2021-11-19 深圳市广利达精密机械有限公司 一种自动化机械加工零件自动加工分拣设备及其方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5092885A (en) 1987-02-12 1992-03-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Peptides with laminin activity
EP0341303A4 (en) 1987-11-19 1990-06-27 Scripps Clinic Res MONOCLONAL ANTIBODY USED AGAINST THE RGD-DIRECTED ADHESION RECEPTOR OF ENDOTHELIAL CELLS.
JPH01169343A (ja) 1987-12-25 1989-07-04 Nippon Sheet Glass Co Ltd ガラス板の切口欠点検出装置
US5135919A (en) 1988-01-19 1992-08-04 Children's Medical Center Corporation Method and a pharmaceutical composition for the inhibition of angiogenesis
EP0398925B1 (en) 1988-01-19 1993-10-20 Children's Hospital Corporation Growth inhibiting agent and the use thereof
US5575815A (en) 1988-08-24 1996-11-19 Endoluminal Therapeutics, Inc. Local polymeric gel therapy
US5686570A (en) 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5112946A (en) 1989-07-06 1992-05-12 Repligen Corporation Modified pf4 compositions and methods of use
US5192744A (en) 1990-01-12 1993-03-09 Northwestern University Method of inhibiting angiogenesis of tumors
ATE130517T1 (de) 1990-08-08 1995-12-15 Takeda Chemical Industries Ltd Intravaskulär embolisierendes mittel mit gehalt an einem die angiogenesis hemmenden stoff.
DE69322860T2 (de) 1992-04-03 1999-07-01 Genentech, Inc., South San Francisco, Calif. Antikörper gegen alpha v beta 3 integrin
SK57693A3 (en) 1992-06-18 1994-07-06 Merck Patent Gmbh Linear peptides and pharmaceutical agents on their base
UA43823C2 (uk) 1992-07-06 2002-01-15 Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН
DE4310643A1 (de) 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
US5981478A (en) 1993-11-24 1999-11-09 La Jolla Cancer Research Foundation Integrin-binding peptides
US5770565A (en) 1994-04-13 1998-06-23 La Jolla Cancer Research Center Peptides for reducing or inhibiting bone resorption
DE19534177A1 (de) 1995-09-15 1997-03-20 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
DE19538741A1 (de) 1995-10-18 1997-04-24 Merck Patent Gmbh Cyclopeptidderivate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FOLKMAN, Nature Medicine, 1995, 1:27-31. *
Технология лекарственных форм./Под ред. Т.С. Кондратьевой. - М.: Медицина, 1991, т.1, с. 65, 131. *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2361614C2 (ru) * 2004-03-24 2009-07-20 ПиДиЭл БАЙОФАРМА, ИНК. ПРИМЕНЕНИЕ АНТИТЕЛ ПРОТИВ α5β1 ДЛЯ ИНГИБИРОВАНИЯ ПРОЛИФЕРАЦИИ РАКОВЫХ КЛЕТОК
RU2365382C2 (ru) * 2004-04-14 2009-08-27 Дженентек, Инк. Композиции и способы для регуляции развития сосудов
RU2401124C2 (ru) * 2005-02-24 2010-10-10 Дзе Скриппс Рисерч Инститьют Реваскуляризация ишемической ткани сетчатки и способ ее скрининга
RU2417099C2 (ru) * 2005-11-04 2011-04-27 Дженентек, Инк. Применение ингибиторов пути комплемента для лечения глазных болезней
RU2434640C2 (ru) * 2006-02-09 2011-11-27 Микромет Аг Лечение метастатического рака молочной железы
RU2600794C2 (ru) * 2010-10-07 2016-10-27 Аэрпио Терапьютикс, Инк. Композиции и способы лечения глазного отека, неоваскуляризации и связанных с ними заболеваний

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AU3218397A (en) 1998-01-05
RU2194528C2 (ru) 2002-12-20
CN1226172A (zh) 1999-08-18
AU738782B2 (en) 2001-09-27
SK163598A3 (en) 1999-06-11
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