RU2194054C2 - Синтетические аналоги il-10 - Google Patents

Синтетические аналоги il-10 Download PDF

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Publication number
RU2194054C2
RU2194054C2 RU98115293/04A RU98115293A RU2194054C2 RU 2194054 C2 RU2194054 C2 RU 2194054C2 RU 98115293/04 A RU98115293/04 A RU 98115293/04A RU 98115293 A RU98115293 A RU 98115293A RU 2194054 C2 RU2194054 C2 RU 2194054C2
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RU
Russia
Prior art keywords
lys
arg
thr
amino acid
polypeptide
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RU98115293/04A
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English (en)
Russian (ru)
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RU98115293A (ru
Inventor
ЛАРСЕН Кристиан ГРЕНХЕЙ
Борбала ГЕССЕР
Original Assignee
Стено Рисерч Груп А/С
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Publication of RU98115293A publication Critical patent/RU98115293A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
RU98115293/04A 1996-01-18 1997-01-16 Синтетические аналоги il-10 RU2194054C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/DK1996/000029 WO1997026278A1 (en) 1996-01-18 1996-01-18 Synthetic il-10 analogues
WOPCT/DK96/00029 1996-01-18

Publications (2)

Publication Number Publication Date
RU98115293A RU98115293A (ru) 2000-05-20
RU2194054C2 true RU2194054C2 (ru) 2002-12-10

Family

ID=8155499

Family Applications (1)

Application Number Title Priority Date Filing Date
RU98115293/04A RU2194054C2 (ru) 1996-01-18 1997-01-16 Синтетические аналоги il-10

Country Status (14)

Country Link
US (1) US6936586B1 (enExample)
EP (1) EP0879245A1 (enExample)
JP (1) JP2000503652A (enExample)
KR (1) KR19990077344A (enExample)
CN (1) CN1226899A (enExample)
AP (1) AP883A (enExample)
AR (1) AR006517A1 (enExample)
AU (2) AU4385696A (enExample)
BR (1) BR9707036A (enExample)
CA (1) CA2243275A1 (enExample)
PL (1) PL327928A1 (enExample)
RU (1) RU2194054C2 (enExample)
WO (2) WO1997026278A1 (enExample)
ZA (1) ZA9784B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2260598C2 (ru) * 2003-10-29 2005-09-20 Российский кардиологический научно-производственный комплекс Министерства здравоохранения РФ Пептид, обладающий способностью ингибировать миграцию моноцитарных клеток, стимулированную белком мср-1
RU2440134C2 (ru) * 2006-11-29 2012-01-20 Дженентек, Инк. Гетеродимерные полипептиды il-17 a/f и возможности их лечебного применения

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997026278A1 (en) * 1996-01-18 1997-07-24 Steeno Research Group A/S Synthetic il-10 analogues
WO1998010792A1 (en) * 1996-09-11 1998-03-19 Prendergast Patrick T Immune direction therapy
WO1999018942A1 (en) * 1997-10-10 1999-04-22 Imperial College Innovations Ltd. Use of csaidtm compounds for the management of uterine contractions
DE19851675A1 (de) * 1998-11-10 2000-05-11 Bayer Ag Menschliche Interleukin-10 Mutantenproteine
JP2002532556A (ja) * 1998-12-22 2002-10-02 シェリング・コーポレーション Ｃ型肝炎ウイルス感染のインターロイキン−１０での処置
AU2001245453B2 (en) * 2000-03-14 2005-08-25 National Jewish Medical And Research Center Method and composition for treating airway hyperresponsiveness
US6797722B2 (en) * 2002-05-03 2004-09-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases
GB0500643D0 (en) * 2005-01-13 2005-02-23 Renovo Ltd Medicaments
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CA2682174C (en) 2007-03-28 2021-04-06 President And Fellows Of Harvard College Stitched polypeptides
CN101980718A (zh) * 2008-02-08 2011-02-23 爱勒让治疗公司 治疗性的拟肽大环化合物
AU2014201269B2 (en) * 2008-02-08 2016-09-15 Aileron Therapeutics, Inc. Therapeutic peptidomimetic macrocycles
RU2639523C2 (ru) 2011-10-18 2017-12-21 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы и их применение
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES CROSS-LINKED WITH TRIAZOLE AND THIOETHER
WO2013123266A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2014138429A2 (en) 2013-03-06 2014-09-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and use thereof in regulating hif1alpha
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN108368161A (zh) 2015-09-10 2018-08-03 艾瑞朗医疗公司 作为mcl-1调节剂的拟肽大环化合物
EP4252629A3 (en) 2016-12-07 2023-12-27 Biora Therapeutics, Inc. Gastrointestinal tract detection methods, devices and systems
WO2018183931A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Treatment of a disease of the gastrointestinal tract with il-10 or an il-10 agonist
JP7482866B2 (ja) 2018-11-19 2024-05-14 ビオラ・セラピューティクス・インコーポレイテッド 生物学的治療薬による疾患処置方法およびデバイス
BR102019007044A2 (pt) * 2019-04-05 2021-12-28 Universidade Federal de Uberlândia Peptídeos sintéticos com afinidade ao receptor de interleucina-10, composição farmacêutica e uso dos mesmos como imunomuduladores no tratamento de doenças autoimunes, inflamatórias ou alérgicas
CN121197633A (zh) 2019-12-13 2025-12-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置

Citations (6)

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Publication number Priority date Publication date Assignee Title
WO1993017698A1 (en) * 1992-03-04 1993-09-16 Schering Corporation Use of interleukin-10 to suppress graft-vs.-host disease
US5328989A (en) * 1993-03-05 1994-07-12 Schering-Plough Purification of human interleukin-10 from a cell culture medium
WO1995003411A1 (en) * 1993-07-26 1995-02-02 Schering Corporation Agonists and antagonists of human interleukin-10
WO1995006657A1 (en) * 1993-08-30 1995-03-09 The General Hospital Corporation Interleukin-10 and immunosuppression
RU2051922C1 (ru) * 1992-06-19 1996-01-10 Людмила Яковлевна Соловьева СПОСОБ ВЫДЕЛЕНИЯ РЕКОМБИНАНТНОГО ИНТЕРЛЕЙКИНА - 1β ИЗ БИОМАССЫ МИКРООРГАНИЗМОВ
WO1996001318A1 (en) * 1994-07-05 1996-01-18 Steeno Research Group A/S Immunomodulators

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US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
IL94878A (en) * 1989-06-28 2003-01-12 Schering Corp Cytokine synthesis inhibitory factor, antagonists thereof and methods of using same
CA2085291A1 (en) 1992-07-30 1994-01-31 Martin L. Breitman Novel receptor tyrosine kinase
US5446128A (en) 1993-06-18 1995-08-29 The Board Of Trustees Of The University Of Illinois Alpha-helix mimetics and methods relating thereto
US5654276A (en) * 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
WO1997026278A1 (en) * 1996-01-18 1997-07-24 Steeno Research Group A/S Synthetic il-10 analogues

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017698A1 (en) * 1992-03-04 1993-09-16 Schering Corporation Use of interleukin-10 to suppress graft-vs.-host disease
RU2051922C1 (ru) * 1992-06-19 1996-01-10 Людмила Яковлевна Соловьева СПОСОБ ВЫДЕЛЕНИЯ РЕКОМБИНАНТНОГО ИНТЕРЛЕЙКИНА - 1β ИЗ БИОМАССЫ МИКРООРГАНИЗМОВ
US5328989A (en) * 1993-03-05 1994-07-12 Schering-Plough Purification of human interleukin-10 from a cell culture medium
WO1995003411A1 (en) * 1993-07-26 1995-02-02 Schering Corporation Agonists and antagonists of human interleukin-10
WO1995006657A1 (en) * 1993-08-30 1995-03-09 The General Hospital Corporation Interleukin-10 and immunosuppression
WO1996001318A1 (en) * 1994-07-05 1996-01-18 Steeno Research Group A/S Immunomodulators

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Benjamin D., Cancer Treat. Res. 1995, 80, 305-319. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2260598C2 (ru) * 2003-10-29 2005-09-20 Российский кардиологический научно-производственный комплекс Министерства здравоохранения РФ Пептид, обладающий способностью ингибировать миграцию моноцитарных клеток, стимулированную белком мср-1
RU2440134C2 (ru) * 2006-11-29 2012-01-20 Дженентек, Инк. Гетеродимерные полипептиды il-17 a/f и возможности их лечебного применения

Also Published As

Publication number Publication date
AP883A (en) 2000-10-25
AP9801295A0 (en) 1998-09-30
AR006517A1 (es) 1999-09-08
KR19990077344A (ko) 1999-10-25
US6936586B1 (en) 2005-08-30
AU4385696A (en) 1997-08-11
WO1997026278A1 (en) 1997-07-24
CA2243275A1 (en) 1997-07-24
BR9707036A (pt) 1999-08-31
AU718476B2 (en) 2000-04-13
PL327928A1 (en) 1999-01-04
EP0879245A1 (en) 1998-11-25
JP2000503652A (ja) 2000-03-28
AU1301197A (en) 1997-08-11
ZA9784B (en) 1997-07-17
CN1226899A (zh) 1999-08-25
WO1997026279A1 (en) 1997-07-24

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20060117