JP2020505324A5 - - Google Patents

Info

Publication number

JP2020505324A5

JP2020505324A5 JP2019534141A JP2019534141A JP2020505324A5 JP 2020505324 A5 JP2020505324 A5 JP 2020505324A5 JP 2019534141 A JP2019534141 A JP 2019534141A JP 2019534141 A JP2019534141 A JP 2019534141A JP 2020505324 A5 JP2020505324 A5 JP 2020505324A5

Authority

JP

Japan

Prior art keywords

seq

pharmaceutical composition

peptide

composition according

expression

Prior art date

2018-01-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 15
• 108090000765 processed proteins & peptides Proteins 0.000 claims 13
• 230000000694 effects Effects 0.000 claims 8
• 108090000623 proteins and genes Proteins 0.000 claims 8
• 208000021386 Sjogren Syndrome Diseases 0.000 claims 5
• 239000012634 fragment Substances 0.000 claims 5
• 210000002865 immune cell Anatomy 0.000 claims 5
• 239000000126 substance Substances 0.000 claims 5
• 102000000589 Interleukin-1 Human genes 0.000 claims 4
• 108010002352 Interleukin-1 Proteins 0.000 claims 4
• 150000001413 amino acids Chemical group 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 108010028006 B-Cell Activating Factor Proteins 0.000 claims 3
• 102100027581 Forkhead box protein P3 Human genes 0.000 claims 3
• 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 claims 3
• 208000034943 Primary Sjögren syndrome Diseases 0.000 claims 3
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 3
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 3
• 102100036922 Tumor necrosis factor ligand superfamily member 13B Human genes 0.000 claims 3
• 102000006639 indoleamine 2,3-dioxygenase Human genes 0.000 claims 3
• 108020004201 indoleamine 2,3-dioxygenase Proteins 0.000 claims 3
• 210000005105 peripheral blood lymphocyte Anatomy 0.000 claims 3
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 3
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
• 208000006820 Arthralgia Diseases 0.000 claims 2
• 102000004127 Cytokines Human genes 0.000 claims 2
• 108090000695 Cytokines Proteins 0.000 claims 2
• 101001128393 Homo sapiens Interferon-induced GTP-binding protein Mx1 Proteins 0.000 claims 2
• 102100031802 Interferon-induced GTP-binding protein Mx1 Human genes 0.000 claims 2
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 208000024891 symptom Diseases 0.000 claims 2
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
• 208000008822 Ankylosis Diseases 0.000 claims 1
• 206010011224 Cough Diseases 0.000 claims 1
• 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
• 206010013774 Dry eye Diseases 0.000 claims 1
• 206010013786 Dry skin Diseases 0.000 claims 1
• 108030002935 Dynamin GTPases Proteins 0.000 claims 1
• 208000010201 Exanthema Diseases 0.000 claims 1
• 102000014150 Interferons Human genes 0.000 claims 1
• 108010050904 Interferons Proteins 0.000 claims 1
• 206010023198 Joint ankylosis Diseases 0.000 claims 1
• 101150112867 MX1 gene Proteins 0.000 claims 1
• 206010039408 Salivary gland enlargement Diseases 0.000 claims 1
• 102000009618 Transforming Growth Factors Human genes 0.000 claims 1
• 108010009583 Transforming Growth Factors Proteins 0.000 claims 1
• 206010047791 Vulvovaginal dryness Diseases 0.000 claims 1
• 238000007792 addition Methods 0.000 claims 1
• 150000001408 amides Chemical group 0.000 claims 1
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 230000037430 deletion Effects 0.000 claims 1
• 238000012217 deletion Methods 0.000 claims 1
• 230000009266 disease activity Effects 0.000 claims 1
• 206010013781 dry mouth Diseases 0.000 claims 1
• 230000037336 dry skin Effects 0.000 claims 1
• 201000005884 exanthem Diseases 0.000 claims 1
• 229940079322 interferon Drugs 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 230000002035 prolonged effect Effects 0.000 claims 1
• 206010037844 rash Diseases 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1