RU2175136C2 - Способ и соединения для обнаружения аналитов с помощью измерения остаточной магнитной индукции и их применение - Google Patents

Способ и соединения для обнаружения аналитов с помощью измерения остаточной магнитной индукции и их применение Download PDF

Info

Publication number
RU2175136C2
RU2175136C2 RU97116162/14A RU97116162A RU2175136C2 RU 2175136 C2 RU2175136 C2 RU 2175136C2 RU 97116162/14 A RU97116162/14 A RU 97116162/14A RU 97116162 A RU97116162 A RU 97116162A RU 2175136 C2 RU2175136 C2 RU 2175136C2
Authority
RU
Russia
Prior art keywords
substances
ferromagnetic
ferrimagnetic
specific structure
binding
Prior art date
Application number
RU97116162/14A
Other languages
English (en)
Russian (ru)
Other versions
RU97116162A (ru
Inventor
Вернер ВАЙЧИС (DE)
Вернер ВАЙЧИС
Роман КЕТИТЦ (DE)
Роман КЕТИТЦ
Лутц ТРАМС (DE)
Лутц ТРАМС
Томас БУНТЕ (DE)
Томас БУНТЕ
Original Assignee
Шеринг Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шеринг Аг filed Critical Шеринг Аг
Publication of RU97116162A publication Critical patent/RU97116162A/ru
Application granted granted Critical
Publication of RU2175136C2 publication Critical patent/RU2175136C2/ru

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU97116162/14A 1995-03-01 1996-02-29 Способ и соединения для обнаружения аналитов с помощью измерения остаточной магнитной индукции и их применение RU2175136C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19508772.0 1995-03-01
DE19508772A DE19508772C2 (de) 1995-03-01 1995-03-01 Verfahren und Verbindungen zur Detektion von Analyten mittels Remanenzmessung und deren Verwendung

Publications (2)

Publication Number Publication Date
RU97116162A RU97116162A (ru) 1999-08-10
RU2175136C2 true RU2175136C2 (ru) 2001-10-20

Family

ID=7756385

Family Applications (1)

Application Number Title Priority Date Filing Date
RU97116162/14A RU2175136C2 (ru) 1995-03-01 1996-02-29 Способ и соединения для обнаружения аналитов с помощью измерения остаточной магнитной индукции и их применение

Country Status (23)

Country Link
US (1) US7033841B1 (enExample)
EP (1) EP0812422B1 (enExample)
JP (1) JP3628704B2 (enExample)
KR (1) KR100416186B1 (enExample)
CN (1) CN1144048C (enExample)
AT (1) ATE197507T1 (enExample)
AU (1) AU706804B2 (enExample)
CA (1) CA2214267A1 (enExample)
DE (2) DE19508772C2 (enExample)
DK (1) DK0812422T3 (enExample)
ES (1) ES2153565T3 (enExample)
FI (1) FI973561A7 (enExample)
GR (1) GR3035495T3 (enExample)
HU (1) HU221384B1 (enExample)
IL (1) IL117201A (enExample)
MX (1) MX9706437A (enExample)
NO (1) NO974000L (enExample)
NZ (1) NZ303196A (enExample)
PT (1) PT812422E (enExample)
RU (1) RU2175136C2 (enExample)
UA (1) UA51646C2 (enExample)
WO (1) WO1996027133A1 (enExample)
ZA (1) ZA961704B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2528885C2 (ru) * 2011-10-04 2014-09-20 Общество с ограниченной ответственностью "Инноград Пущино" Способ детекции аналита из раствора на частицах и устройство для его реализации

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19615254C2 (de) * 1996-04-18 1999-03-11 Diagnostikforschung Inst Gerät zur höchstempfindlichen magnetischen Detektion von Analyten
US6592820B1 (en) * 1998-11-05 2003-07-15 Bio-Spectrum Technologies, Inc. System and method for biochemical assay
JP2001147230A (ja) * 1999-11-19 2001-05-29 Hitachi Software Eng Co Ltd バイオチップ読取装置及び標識試薬
JP3962385B2 (ja) 2004-03-11 2007-08-22 株式会社日立製作所 免疫検査装置及び免疫検査方法
JP4347107B2 (ja) * 2004-03-26 2009-10-21 株式会社イノアックコーポレーション 磁気的免疫反応測定のための試験容器およびその製造方法
US8217647B2 (en) * 2006-12-19 2012-07-10 Koninklijke Philips Electronics N.V. Measuring agglutination parameters
KR100863153B1 (ko) * 2007-02-15 2008-10-13 엘지마이크론 주식회사 질병 진단용 바이오 센서 및 카트리지와 이를 이용한 질병진단 시스템
CN101918842A (zh) * 2007-11-20 2010-12-15 3M创新有限公司 利用含二乙炔的聚合物传感器分析细菌样品的方法
DE102008013997B4 (de) 2008-03-13 2012-10-31 Bundesrepublik Deutschland, vertr. durch d. Bundesministerium f. Wirtschaft und Technologie, dieses vertreten durch d. Präsidenten d. Physikalisch-Technischen Bundesanstalt Verfahren zum quantitativen Nachweis von Analyten in flüssigem Medium
DE102008057081A1 (de) * 2008-11-13 2010-05-20 Siemens Aktiengesellschaft Vorrichtung und Verfahren zur Bestimmung der Menge ferromagnetischer Partikel in einer Suspension
CN105102979B (zh) * 2013-01-29 2017-05-03 生物辐射海法有限公司 利用磁性纳米粒子的检测测定法
CN108333536B (zh) * 2017-01-20 2021-11-19 国家纳米科学中心 基于纵向弛豫时间信号读出的磁传感器及其构建方法、用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661408A (en) * 1986-03-18 1987-04-28 E.I. Du Pont De Nemours And Company Coated chromium dioxide particles

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1156795A (en) 1979-04-11 1983-11-08 Richard G. Newell Curable fluorocarbon substituted polyetherurethaneacrylates
FR2461521A1 (fr) * 1979-07-20 1981-02-06 Anvar Fluides magnetiques, notamment ferrofluides, et procede pour leur obtention
CA1235856A (en) 1983-03-23 1988-05-03 Reiho Takabe Biocompatible composite material
EP0180384B1 (en) * 1984-11-01 1991-04-24 TECHNICON INSTRUMENTS CORPORATION(a Delaware corporation) Magnetically responsive reagent carrier and method of preparation
US4824587A (en) * 1985-03-18 1989-04-25 The Dow Chemical Company Composites of coercive particles and superparamagnetic particles
US4849210A (en) * 1985-05-08 1989-07-18 Molecular Biosystems, Inc. Magnetic resonance imaging of liver and spleen with superparamagnetic contrast agents
WO1987001040A1 (en) 1985-08-23 1987-02-26 Washington Research Foundation Polymeric intraocular lens material having improved surface properties
US5597531A (en) * 1985-10-04 1997-01-28 Immunivest Corporation Resuspendable coated magnetic particles and stable magnetic particle suspensions
IT1190428B (it) 1985-12-05 1988-02-16 Ausimont Spa Poliesteri fluorurati
US4724390A (en) * 1986-03-24 1988-02-09 Rauscher Elizabeth A Non-superconducting apparatus for detecting magnetic and electromagnetic fields
US5100689A (en) 1987-04-10 1992-03-31 University Of Florida Surface modified surgical instruments, devices, implants, contact lenses and the like
US4913883A (en) * 1987-07-20 1990-04-03 Hitachi, Ltd. Particle agglutination immunoassay apparatus
FR2620624B1 (fr) 1987-09-23 1993-08-20 Irap Article en materiau polymere, modifie en surface pour presenter une hemocompatibilite amelioree et une thrombogeneicite diminuee, et son procede d'obtention
JPH0235774A (ja) * 1988-07-26 1990-02-06 Matsushita Electric Ind Co Ltd 半導体装置
JP2938918B2 (ja) * 1990-01-25 1999-08-25 ティーディーケイ株式会社 磁気微粒子の粒度測定方法
GB9007408D0 (en) * 1990-04-02 1990-05-30 Nycomed As Compositions
US5164297A (en) * 1990-05-03 1992-11-17 Advanced Magnetics Inc. Solvent mediated relaxation assay system
IL98744A0 (en) * 1990-07-06 1992-07-15 Gen Hospital Corp Method of studying biological tissue using monocrystalline particles
FR2669226B1 (fr) 1990-11-21 1997-01-03 Irap Dispositif a usage ophtalmologique forme d'un substrat polymerique comportant des groupements fluores en surface, et procede d'obtention.
DE4117782C2 (de) * 1991-05-28 1997-07-17 Diagnostikforschung Inst Nanokristalline magnetische Eisenoxid-Partikel, Verfahren zu ihrer Herstellung sowie diagnostische und/oder therapeutische Mittel
US5464696A (en) * 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
DE4309333A1 (de) * 1993-03-17 1994-09-22 Silica Gel Gmbh Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben
CA2147813A1 (en) 1994-04-28 1995-10-29 Richard Dixon Intravascular prosthesis with anti-thrombogenic coating
US5700559A (en) 1994-12-16 1997-12-23 Advanced Surface Technology Durable hydrophilic surface coatings
DE19503664C2 (de) * 1995-01-27 1998-04-02 Schering Ag Magnetorelaxometrische Detektion von Analyten
DE19514104C2 (de) 1995-04-13 1997-05-28 Behringwerke Ag Beschichtung für in den Blutstrom oder in das Gewebe des menschlichen Körpers einbringbares Biomaterial
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
DE19535729A1 (de) 1995-09-26 1997-03-27 Huels Chemische Werke Ag Mikroorganismenabweisende Oberflächen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661408A (en) * 1986-03-18 1987-04-28 E.I. Du Pont De Nemours And Company Coated chromium dioxide particles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2528885C2 (ru) * 2011-10-04 2014-09-20 Общество с ограниченной ответственностью "Инноград Пущино" Способ детекции аналита из раствора на частицах и устройство для его реализации

Also Published As

Publication number Publication date
UA51646C2 (uk) 2002-12-16
ZA961704B (enExample) 1996-07-29
DE19508772A1 (de) 1996-09-05
CN1177401A (zh) 1998-03-25
ATE197507T1 (de) 2000-11-11
DE19508772C2 (de) 1998-01-29
JPH11508031A (ja) 1999-07-13
IL117201A (en) 2000-11-21
AU4943496A (en) 1996-09-18
HUP9800225A3 (en) 1999-03-01
WO1996027133A1 (de) 1996-09-06
KR19980702665A (ko) 1998-08-05
HUP9800225A2 (hu) 1998-04-28
PT812422E (pt) 2001-03-30
GR3035495T3 (en) 2001-05-31
NO974000D0 (no) 1997-09-01
HU221384B1 (en) 2002-09-28
EP0812422A1 (de) 1997-12-17
JP3628704B2 (ja) 2005-03-16
MX9706437A (es) 1997-11-29
NO974000L (no) 1997-09-01
KR100416186B1 (ko) 2004-03-18
US7033841B1 (en) 2006-04-25
DE59606129D1 (de) 2000-12-14
NZ303196A (en) 1999-04-29
AU706804B2 (en) 1999-06-24
CA2214267A1 (en) 1996-09-06
CN1144048C (zh) 2004-03-31
IL117201A0 (en) 1996-06-18
ES2153565T3 (es) 2001-03-01
FI973561A0 (fi) 1997-08-29
FI973561L (fi) 1997-08-29
FI973561A7 (fi) 1997-08-29
DK0812422T3 (da) 2001-01-29
EP0812422B1 (de) 2000-11-08

Similar Documents

Publication Publication Date Title
RU2176393C2 (ru) Способ и соединения для магниторелаксометрического обнаружения аналитов и их применение
US6825655B2 (en) Method and arrangement for detecting changes of a magnetic response in magnetic particles
JP4171139B2 (ja) 磁性体標識による免疫検査方法とその装置
RU97114745A (ru) Способ и соединения для магниторелаксометрического обнаружения аналитов и их применение
RU2175136C2 (ru) Способ и соединения для обнаружения аналитов с помощью измерения остаточной магнитной индукции и их применение
EP1421382A1 (en) Methdo and arrangement for analyzing substances
US20030076087A1 (en) Method and arrangement relating to substance analysis
Yang et al. Development of antibody functionalized magnetic nanoparticles for the immunoassay of carcinoembryonic antigen: a feasibility study for clinical use
JP2003528289A (ja) 磁性粒子の二重屈折の緩和の測定を利用する結合反応を検出するための方法
Tsukada et al. Using magnetic field gradients to shorten the antigen-antibody reaction time for a magnetic immunoassay
US20020123079A1 (en) Process for detecting or quantifying a biological rreaction using superparamagnetic label
JP2004530103A (ja) 超常磁性標識を用いて生物学的反応を検出または定量する方法
Li et al. Magnetism of iron oxide nanoparticles and magnetic biodetection
MXPA97005543A (en) Processes and compounds for magnetorrelaxometric detection of analytics and its
JP2005084023A (ja) 磁性粒子を利用した分析装置
HK1009181A (en) Process and compounds for use in detecting analytes by measurement of residual magnetism, and the use of the said compounds
HK1008563A (en) Process and compounds for the magnetorelaxometric detection of analytes and use thereof

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20050301