RU2174021C1 - Method for treating tumors - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves exposing tumor to ultra-high frequency radiation with wavelength of 1.3-2 cm before applying hyperthermia treatment. Resonance frequency absorbable by the tumor is determined. Then the like action is applied to adjacent healthy tissues and absorption resonance frequency is determined for these healthy tissues. Tumor and healthy tissue absorption resonance frequency control is carried out concurrently with hyperthermia treatment. The tumor and healthy tissue absorption resonance frequency value convergence is interpreted in terms of treatment effectiveness. EFFECT: enhanced effectiveness of treatment.

Description

 The invention relates to medicine, namely to Oncology, and can be used in the treatment of locally advanced tumors of various localizations.

A known method of treating tumors (see Theory and Techniques. - 1981. - T. 3. - S. 256-260), which consists in carrying out hyperthermia by exposing the tumor to microwave radiation with a power of 30 W at a wavelength of 6.5 cm. this, the heating of the tumor is carried out to 42 ^o C for 30 minutes

 However, the reliability of the effectiveness of treatment with this method is small, since the method does not provide for monitoring the treatment process. The effectiveness of the therapeutic effect in the treatment process is evaluated only by clinical signs.

 There is also known a method of treating a tumor (see Proliferative skin diseases. - M .: 1985. - S. 34-36) by chipping the lesion in surrounding healthy tissue with an inhibitor, which is used as human interferon.

 However, the use of inhibitors is not very effective, since there is a violation of the blood flow of not only healthy, but also diseased tissues. In addition, the reliability of the effectiveness of treatment is not objective, since there is no control of the therapeutic effect of inhibitors in the process.

Closest to the claimed is a method of treating tumors (see RF patent N 2048824 according to class A 61 N 5/02, publ. 11/27/95), which consists in introducing an inhibitor (a solution of mesatonin) into the healthy tissues bordering the tumor and subsequent exposure to the tumor with hyperthermia. In this case, the heating of the tumor is carried out by any heat radiator capable of warming up the tumor in full to 42 ^o C for 30 minutes

 However, the effectiveness of treatment, as well as previous analogues, is small, since there is no control over the treatment process. Using only temperature control does not ensure the reliability of the therapeutic effect.

 The invention is aimed at solving the problem of increasing the effectiveness of treatment while ensuring the reliability of the therapeutic effect.

 To solve the problem in the method of treating tumors, which consists in hyperthermia, according to the invention, before exposure to hyperthermia, the tumor is exposed to microwave radiation with a wavelength of 1.3-2 cm and the value of the resonant frequency of absorption of the tumor is detected, after which a similar effect on the borderline healthy tissues with a tumor and also reveal the value of the resonant absorption frequency of these healthy tissues, simultaneously with hyperthermia control the values of the resonance absorption frequency of the tumor oli and healthy tissues and when converging the values of the resonant frequencies of absorption of the tumor and healthy tissues judge the effectiveness of treatment.

 The sources of patent and scientific and technical information known to the authors do not describe a method for treating a tumor, which makes it possible to increase the effectiveness of treatment, while ensuring the reliability of the therapeutic effect due to the possibility of comparing the values of the resonant absorption frequencies of the tumor and healthy tissues bordering on it during hyperthermia. The influence of microwave radiation at the resonant frequency corresponding to the natural frequency of oscillation of the tumor molecules leads to the dissociation of tumor molecules, since they absorb more energy than healthy tissue molecules. The effect of hyperthermia in combination with resonant vibrations of the tumor molecules leads to the destruction of the tumor, thereby increasing the effectiveness of the treatment. Moreover, comparing the values of the resonance frequencies of absorption of the tumor and healthy tissues during hyperthermia, it is possible to reliably evaluate the effectiveness of the therapeutic effect.

 The foregoing allows us to conclude that there is a criterion of "inventive step" in the claimed invention.

 The method is as follows.

The tumor is affected by microwave radiation with a power of 1-10 mW / cm ² wavelength of 1.3-2 cm. By smoothly adjusting the frequency of radiation, fix the value of the resonant absorption frequency of the tumor. Then a similar procedure is performed on healthy tissues bordering the tumor. After that, hyperthermia is effected using a microwave emitter, for example, using the Luch-2 apparatus, heating the entire tumor volume to 42 ^° C for 20-30 minutes. Simultaneously with hyperthermia, the resonance frequency of tumor absorption is monitored.

 When a coincidence or convergence of the value of the resonant frequency of absorption of the tumor with the value of the resonant frequency of absorption of healthy tissues bordering the tumor is judged on the positive dynamics of the therapeutic effect. In the absence of convergence of values, the treatment session is repeated.

 The choice of the wavelength of microwave radiation (1.3-2 cm) at which the values of the resonance absorption frequencies are detected is chosen experimentally based on the selection of the resonance frequencies of various tumor samples and healthy tissues bordering them.

The power range of 1-10 mW / cm ^{2 is} selected based on safety considerations for its use for human health.

 Example 1

The tumor - osteoblastoclastoma - was exposed to microwave radiation with a power of 1 mW / cm ² . Resonant absorption of the tumor was observed at a frequency of 18.8 GHz, which corresponded to a wavelength of λ = 1.59 cm. The resonance frequency of absorption of healthy tissues bordering the tumor was 17.6 GHz, respectively, λ = 1.7 cm. Then, the tumor was subjected to hyperthermia by exposure to it with microwave radiation with a power of 20 W at a frequency of 2450 MHz using the Luch-2 device for 20 minutes The heating temperature was maintained at 42-43 ^o C. In the process of hyperthermia, the value of the resonance absorption frequencies was monitored. The value of the resonant frequency of absorption of the tumor shifted toward closer to the value of the resonant frequency of absorption of healthy tissues bordering the tumor. When conducting 3 sessions of hyperthermia, the values of the resonant frequencies of absorption of the tumor and healthy tissues coincided, which allowed us to conclude about the process of tumor necrotization.

 Example 2

The tumor - chondroma - was exposed to microwave radiation with a power of 1 mW / cm ² . Resonant absorption of the tumor was observed at a frequency of 21.8 GHz, which corresponded to a wavelength of λ = 1.37 cm, and the value of the resonant frequency of absorption of healthy tissues bordering the tumor was 21.0 GHz, respectively, λ = 1.43 cm. After carrying out hyperthermia in In accordance with the procedure described in Example 1, at first, the approximation of the values of the resonance frequencies was observed, and then (after two sessions of hyperthermia) - a complete coincidence of the values. It was concluded that tumor necrotization.

 Similar results were obtained in the treatment of chondrosarcoma, chondroblast, osteoblastoclasts of various locations, hemangiomas and other tumors.

 Thus, on the basis of the results obtained, it can be concluded that the claimed method increases the effectiveness of treatment of the tumor, while ensuring the reliability of the therapeutic effect.

Claims (1)

 A method of treating tumors, comprising exposing the tumor to microwave hyperthermia, characterized in that before exposure to hyperthermia, the tumor is exposed to microwave radiation with a wavelength of 1.3-2 cm and the resonant absorption frequency of the tumor is detected, and then a similar effect is applied to healthy tissues bordering the tumor and reveal the value of the resonant absorption frequency of these healthy tissues; simultaneously with hyperthermia, control the values of the resonance absorption frequencies of the tumor and healthy tissues and when the values of the resonance frequencies of the absorption of the tumor and healthy tissues come closer, they judge the effectiveness of the treatment.