RU2186584C1 - Biosynchronization system of physiotherapeutic and destructive impact processes - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: system suggested is designed to conduct biosynchronization of the impact at certain pulse and breathing phases while working with present physiotherapeutic preparations and other sources of physical impact. The suggested system contains pulse and breathing pickup units switched through corresponding amplifiers to the input of the first and second managing centers. Output of every amplifier is switched to controlled input of the first and second switchboards, correspondingly. Switchboards are involved into the successive chain between an output of physiotherapeutic impact source or any other physical impact source and impact object. Biosynchronization system enables to considerably increase the efficiency of available equipment for physiotherapy, electrophoresis, massaging devices. It favors to increase the quality and decrease the damage of surrounding healthy tissue while working with surgical lasers, ultrasound and other devices. EFFECT: higher efficiency. 5 cl, 1 tbl, 6 ex, 2 dwg

Description

 The invention relates to medicine, namely to devices for physiotherapy, and can be used with commercially available devices as a component of an additional biosynchronization unit - a biocontrolled key - at the output of such devices or other sources of physical effects.

 There are a large number of devices for electrotherapy, electrophoresis of drugs and other substances, devices for diadynamic therapy, amplipulse therapy, fluctuatorization, inductothermy, microwave therapy, franklinization, aeroionotherapy, aerosol therapy, magnetotherapy, ultrasound therapy and phonophoresis of drugs, mechanical and vibration massagers, massage, light therapy with incandescent lamps and sources of ultraviolet radiation, laser therapy using diode, solid state and gas lasers, tgenoterapii, surgical lasers, lasers to photodynamic therapy apparatus for irradiating beams of gamma particles, protons, and synchrotron radiation [1, 2].

 Existing devices for physiotherapy affect the tissues and the human body without taking into account the phases of blood supply to the tissue, the phases of the biorhythms of the heartbeat and respiration of the patient. However, not only the magnitude of the response, but even its sign depends on the phases of these biorhythms [3-6]. For the therapeutic effect, the predominant enhancement of biosynthetic restoration processes relative to destructive ones, it is necessary to synchronize the physiotherapeutic effect with the phases of enhancing the energy supply of active cell responses with the highest sensitivity, over which the capillaries open, oxygen diffusion and transport of energy substrates are intensified when tissue blood supply to the systole and inspiration phases increases. For selective destruction of cancer cells, removal of skin defects with the least damage to surrounding healthy tissue, to reduce the area of necrosis and thermal denaturation, to reduce the effective dose of x-ray, gamma radiation or other damaging effects, on the contrary, synchronization of physical effects (laser, x-ray, etc.) is necessary with phases of decreasing blood supply to the tissue, decreasing heat capacity and thermal conductivity of the tissue at the site of exposure, ie, synchronization with the phases of expiration and diastole [7]. Accordingly, with aerosol therapy, it is advisable to synchronize the effect with the patient's breath without biofeedback of the pulse sensor signals.

 Closest to the proposed device is a physiotherapy device containing a first potentiometer, a power amplifier, a switch and a generator, the output of which is connected to one input of the switch, a pulse sensor in series, a first amplifier and a second potentiometer, a breathing sensor, a second amplifier and a third potentiometer in series serially connected adder, to the inputs of which are connected the first - third potentiometers and a delay line, the output of which is connected to the input of the amplifier a polarity switch, one input of which is connected to the output of the power amplifier, and the outputs are connected to the second inputs of the switch, and a control and indication unit, the outputs of which are connected to the other input of the polarity switch and the third input of the switch [4]. This device provides biofeedback by the intensity of the physiotherapeutic effect according to signals from the patient's pulse and respiration sensors.

 However, this device cannot be used for biosynchronization with certain phases of the pulse and respiration with existing physiotherapeutic apparatuses and sources of physical effects.

 The technical result is the creation of a system that provides biosynchronization of exposure with certain phases of the pulse and respiration when working with existing physiotherapeutic apparatuses and other sources of physical effects.

 This is achieved by the fact that the biosynchronization system of physiotherapeutic and other physical influences contains a pulse sensor connected through the first amplifier to the input of the first control unit, the output of which is connected to the control input of the first switch, a breathing sensor connected through the second amplifier to the input of the second control unit, the output of which connected to the control input of the second switch, and the first and second switches are included in a serial circuit between the output of the physiotherapeutic source or others GoGo physical impacts or exposure and object are arranged to overlap or sequential diverting physiotherapy or other physical effects with the appropriate mechanical chopper or shutter, in addition, first control portion comprises a series-connected adjustable "NOT" delay element and the element. shunted by a key, and a two-position switch, the input of the delay element being the input of the first control unit, the output of the element "NOT" connected to the opening contact of the two-position switch, the contact being connected to the source bus of the unlocking potential, and the movable contact being the output of the first control unit, and the second the control unit contains an element "NOT", shunted by the key, and a two-position switch, and the input of the element "NOT" is the input of the second control node, to the output of which the movable contact of the on / off switch is connected, the opening contact of which is connected to the output of the “NOT” element, and the closing contact is connected to the bus of the unlocking potential source, each switch containing an electromagnetic relay for acting on a mechanical chopper or curtain, and each switch contains an electromagnet deviations of the flow of physiotherapeutic or other physical effects.

 The essence of the invention lies in the fact that the above set of essential features allows you to use the proposed system with commercially available devices to ensure biosynchronization with certain phases of the rhythms of the pulse and respiration of patients with the possibility of changing the phases of exposure in accordance with the requirements of selective amplification or restoration or destructive processes.

 Comparison with the closest analogue allows us to claim compliance with the criterion of "novelty", and the absence of distinctive features in the analogs indicates compliance with the "inventive step".

 The tests carried out confirm the possibility of wide industrial use.

Figure 1 presents the functional block diagram of the proposed system,
figure 2 - timing diagrams of her work.

 The system comprises a pulse sensor 1 connected through the first amplifier 2 to the input of the first control unit 3, the output of which is connected to the control input of the first switch 4.

 In addition, the system includes a breathing sensor 5 connected through a second amplifier 6 to the input of the second control unit 7, the output of which is connected to the control input of the second switch 8.

 The first and second switches 4 and 8 are connected in a series circuit between the output of the source 9 of physiotherapeutic or other physical effects and the object 10 of the impact or made with the possibility of sequentially blocking or diverting the flow of physiotherapeutic or other physical effects using the appropriate mechanical breaker or curtain (in Fig. No )

 The first control unit 3 may contain a series-connected adjustable delay element 11 and an element "NOT" 12, shunted by the key 13, which can be used as a toggle switch or touch switch. In addition, the control unit 3 contains a two-position switch 14, the opening contact of which is connected to the output of the element "NOT" 12, the closing contact is connected to the bus of the source of the unlocking potential - Votp, and the movable contact is the output of the first control unit 3.

 The second control unit 7 contains an element "NOT" 15, shunted by the key 16, and a two-position switch 17.

 The input of the element "NOT" 15 is the input of the second control unit 7, the output of which is connected to the movable contact of the on-off switch 17, the opening contact of which is connected to the output of the element "NOT" 15, and the closed contact is to the source bus of the unlocking potential VoTP.

 Each of the switches 4 and 8 may contain an electromagnetic relay for acting on a mechanical chopper or curtain (not shown in FIG.). In this case, a mechanical chopper or shutter must be rigidly connected to the anchor of the electromagnet with the possibility of blocking the flow of physiotherapeutic or other physical effects, for example, a beam of a gas or solid-state laser, x-ray, gamma.

 In addition, with the help of an electromagnet, the supply of infused liquid or blood to the body of the object 10 of the exposure can be shut off.

 In addition, each of the switches 4 and 8 may contain an electromagnet to divert the flow of physiotherapeutic or other physical effects.

 In addition, the system includes a block 18 of light or sound indication of the phase of respiration.

 The pulse sensor 1 is a pair of LED-photodiode in the form of clothespins on the finger or on the auricle, the respiration sensor 2 is a thermistor or a thermal diode on an arm in front of the nose or another known design (capacitive, mechanical, graphite) located on the diaphragm movement area. The element 11 of the delay signal of the sensor 1 pulse (to account for the difference in the propagation time of the pulse wave) contains four positions 0, 0.05, 0.1 and 0.15 s depending on the difference between the distance from the heart of the sensor 1 pulse and the area of physical (medical) exposure. Sound indication of the phase of inhalation or exhalation, in which the switch 8 closes the circuit of the apparatus of physical impact, is performed using microdynamics or headphones - block 18.

 In addition, the switches 4 and 8 can be made contactless on semiconductor elements.

 In a variant of a low-current key, biosynchronization can be carried out using an electromagnetic relay to turn on and off a signal from a pulse sensor 1 or from a respiration sensor 5 of an electromagnet to move the shutter (diaphragm) that overlaps in the desired phase (inhalation or exhalation for the respiration sensor or systole or diastole of the heart for a pulse sensor) radiation from a gas laser or other physical influences (gamma radiation, ultraviolet radiation, x-ray radiation in oncology, etc.

 When using biosynchronization for an electrocoagulator with a high-frequency current and high power, for stable operation of the sensors, high-frequency filters and an electronic switch (relay) designed for the corresponding current strength are additionally used. Smoothing the leading and trailing edges of the pulse sensor 1 signal due to the inertia of the core of the electromagnet (inertia of the relay) is acceptable, but should not shift the phase by more than 30%.

 If it is necessary to maintain a constant adjustable signal level in those phases of the pulse and respiration, in which the first switch 4 (biosynchronization in the phase of the pulse) and the second switch 8 (biosynchronization in the phase of the respiration) are in the open state, variable resistors (resistors) can be connected in parallel to them ), with the help of which a constant voltage level (current strength) is regulated, on which additional voltage (current) is superimposed in the phases of the switch closure (Fig. 2 option 3).

 The last option of biosynchronization and the introduction of additional variable resistors into the device are necessary for the biosynchronization of physiologically adequate light, sound and some other physical effects, the perception of which occurs with a pronounced adaptation of sensitivity to the level of exposure. For example, an increase in sound strength during heart systole and during inspiration when listening from any sound reproducing device (music player, tape recorder, etc.) should occur without completely interrupting sound at a certain constant level in other phases of the patient’s pulse and breathing. This method of using biosynchronization is necessary to increase the effect of healing music, learning foreign languages and accelerating the memorization of other information perceived in the form of sound or light signals.

 The system operates as follows.

 The signal of the pulse sensor 1 is fed to the input of the amplifier 2, from the output of which the amplified signal is fed to the input of the first control unit 3 and, through the delay element 11, is supplied to the element "NOT" 12, shunted by the key 13, which makes it possible to set the action phase depending on the position of the latter ( systole or diastole). The initial position of the on-off switch 14 does not affect the control of the switch 4 in a given phase of the pulse, however, when it is switched, the unlocking potential is constantly supplied to the control input of the switch and the latter is constantly closed, without affecting the transmission of physiotherapeutic or other physical effects.

 Similarly, but without delay, the second node 7 control switch 8.

 In this case, the signal from the respiratory sensor 5 after passing through the amplifier 6 is fed to the input of the element "NOT" 15, shunted by the key 16, and then through the on-off switch 17 to the control input of the switch 8, which has an output to the unit 18 for sound indication of the phase of inspiration or expiration.

 When the two-position switch 17 is switched to a different position, a constant unlocking voltage is applied to the control input of the switch 8, as a result of which the switch 8 does not affect the passage of a physiotherapeutic or other physical effect.

 In FIG. 2 shows the signals from the pulse and respiration sensors. In option "1" shows the type of impact on the object, respectively, only in the phases of systole and inspiration.

 In option "2" the output signal of the physiotherapeutic apparatus occurs when the circuit is closed only in the phases of exhalation and diastole.

 In option "3", the signal (current or voltage) at the output of the first and second switches 4 and 8 is amplified in the corresponding phases (options "1" or "2") due to the parallel connected variable resistors against a constant level, the value of which is adjusted for each switch by changing the resistances of the variable resistors connected in parallel to them (not shown in Fig. 1) and increasing the amplitude of the source 9.

 In this case, changing the level of the source of physiotherapeutic or other physical effects and the resistance value of variable resistors, it is possible to obtain different ratios of constant output level and amplitude in the given phases of the pulse and respiration (figure 2, option "3").

 Option 1 uses all physiotherapeutic apparatuses, including all electrical stimulators and electrophoresis apparatuses, electromagnetic and acoustic emitters, including ultrasound for therapeutic purposes (non-damaging doses and powers), droppers, artificial kidney apparatus, all massagers to strengthen muscles, improve tissue nutrition, enhance regeneration and microcirculation, to optimize the training load of athletes and treat injuries.

 In option "2" with exposure only to the phases of diastole and expiration with a decrease in blood supply to the tissue, biosynchronization of the damaging (destructive) intensities of the impacts using surgical lasers, lasers during photodynamic therapy, for a plasma scalpel and electrocoagulator during various operations (prostate adenoma, gynecological, skin, endoscopic, , cutting, evaporation, coagulation and vaporization of defects in the skin and mucous membranes), for biosynchronization (for the purpose of destruction of cells and tissues or for the diagnosis and edovaniya) ultrasonic, ultraviolet, X-ray, gamma. Physiotherapeutic apparatuses, in particular electrical stimulators, can be used in option "2" (exposure in the phases of diastole and expiration) only to combat cellulite and in the treatment of fungal and other infections on the surface of the skin.

 Option 3 uses sound, light, and other physical effects, the sensitivity to which changes dramatically by adapting to the level of exposure, that is, mainly effects on the receptors of the senses of the human body - healing music, sound and light information for educational purposes.

 Example 1. Patient P. 65 years. The diagnosis is chronic venous insufficiency, varicose disease of the lower extremities. Measurement with the Coral apparatus in the lower leg showed an equally reduced level of microcirculation on both limbs. The stimulator "Stimulus" is used in normal mode when exposed to the left limb and with a biosynchronization device with automatic transmission of current only in the phases of systole and inspiration to the right limb. All parameters, including exposure time, were identical. After 10 sessions of electrotherapy for 10 days on the lower leg of the left leg, the level of microcirculation increased from 8.1 ± 0.4 units. to 10.2 ± 0.5 units, and after 7 days it dropped to 9.7 ± 0.4 units. On the right foot using the biosynchronization system, the increase was significantly more significant and stable: 7.9 ± 0.4 before treatment and 18.7 ± 0.6 after treatment, including 18.1 ± 0.5 after a week.

 Example 2. Patient K. 72 years. Trophic ulcers of the lower leg of the same size on the left and right legs, each 4 square cm each. Fifteen daily sessions were carried out with an LGN-111 helium-neon laser irradiation of the right leg ulcer region and with the same parameters of the left leg ulcer, but with irradiation only in the phases of systole and inspiration and interruption of irradiation with an aluminum curtain attached to the electromagnet of the biosynchronization device in phases diastole and exhalation of the patient. Complete epithelialization of the ulcer on the left leg occurred after 13 sessions. On the right leg, the ulcer reduced by the 15th session to 1 sq.cm, and completely closed only 38 days after the start of treatment.

 Example 3. The use of an electrocoagulator for transurethral resection of the Wolf company with a biosynchronization device in 7 patients operated on for prostate adenoma showed that, compared to a control group of 7 patients, biosynchronization of cauterization and electric current cutting only during periods of decreased blood supply to the tissue in diastole phases and exhalation allowed to reduce blood loss by an average of 20 ± 5% and reduce the necrosis zone in histological samples of tissue removed by an average of 22 ± 4 microns.

 Example 4. Patient B. 32 years. In the neck area below the nape of the head are two nevi with a diameter of 3.5 mm. One nevus was removed by vaporization using a 12 W ALTO surgeon semiconductor diode laser in normal mode, the other nevus of almost the same symmetrical localization and size - at the same time with the same laser with the same parameters, it was almost the same, but sequentially to the laser radiation on pedal a biosynchronization device was connected, with which the laser was turned on while the pedal was pressed only during the exhalation and diastole phases (option "2" of Fig. 3). There was no difference in the size of the wounds and the speed of their healing; the operation time was almost the same when both skin defects were removed. However, the cosmetic effect was noticeably different. When using the biosynchronization system, in comparison with the usual method, the scar was practically invisible and did not contain keloid, while the white spot in conventional laser surgery was noticeably larger.

 Example 5. The depth of penetration and the concentration of calcium were compared during electrophoresis of the calcium transporter xidiphon at a constant potential and with a biosynchronization (biocontrol) system. In experiments on rabbits, modulation was used from pulse and respiration sensors installed in the animal’s ear at the site of xidiphon electrophoresis. We studied the concentration of calcium in the muscle, cartilage of the rabbit’s ear and bones of the extremities when the negative electrode was placed in the corresponding place on the limb of the animal. For control, we used the tissues of the ear or limbs of the same animal during electrophoresis of xidiphon at a constant potential (without biosynchronization in the rhythms of blood flow) using the Harmony apparatus. Spent 15 daily sessions lasting 20 minutes. The sequence of electrophoresis at a constant potential and in the biofeedback mode was alternated; in some rabbits, the biofeedback regimen was performed on the left ear and limb, and on others, on the right. After completion of the electrophoresis course, rabbits were sacrificed one day after intravenous injection of chloroform. Pieces of bone and ear tissue or thick sections on a freezing microtome after formalin fixation and washing to remove freely soluble calcium were placed on a ruby substrate and examined by electron-probe X-ray microanalysis modified by us for biological objects [8].

The studies were carried out on a Camebax-micro X-ray microanalyzer of the French company Cames. To determine the local concentration of calcium in the volume of 1-3 μm ³ and the average concentration along the scan line, the intensity of the characteristic radiation was recorded when compared with a standard object (crystals of calcium chloride). In this case, corrections were introduced for the effect of the absorption of X-rays. The results showed that the calcium content in the bone and muscle tissue in the areas of biocontrolled xidiphon electrophoresis significantly exceeded the calcium content in the sites of xidiphon electrophoresis at a constant potential and in areas in which electrophoresis was not performed. On 8 rabbits, the calcium concentration of 32 pieces of muscle and bone tissue was studied (see table).

 Example 6. For 10 subjects aged 12 to 60 years, the% memorization of 15 words (names of various objects) was evaluated for 90 seconds when they were presented on the illuminated display either with constant light brightness (control option) or with a decrease in brightness from a constant level in control during exhalation and during diastole. The scoreboard with a list of items in the control and in the experiment was changed for different subjects. In all test subjects without exception,% of memorized words, regardless of one or another scoreboard, was higher in the experiment (by 1-5 words). When using the biosynchronization system, on average for all subjects, 2.3 words were remembered more (15.3%) than with constant illumination of the scoreboard.

 Thus, the use of a biosynchronization system can significantly increase the efficiency of existing devices for physiotherapy and electrophoresis, as well as various massagers, without changing their design, improve quality and reduce damage to healthy surrounding tissue when supplemented with a device for biosynchronization of surgical lasers and other sources of physical effects on body tissues , improve the diagnostic capabilities of physical methods (ultrasound, x-ray, etc.), automate bio-control trolled inhalation upper airway and to improve the perception training.

Sources of information
1. Technique and methods of physiotherapeutic procedures. Directory, under. ed. V.M. Bogolyubov. - M.: Medicine, 1983.- 352 p.

 2. Bogolyubov V.M., Ponomarenko G.N. General physiotherapy. -M., St. Petersburg: SLP, 1997 .-- 480 p.

 3. Zaguskin S. L. Biorhythms: energy and management. / Preprint IOFAN 236, M., 1986. - 56 p.

 4. Zaguskin S.L. Device for physiotherapy. RF patent 2033204. Priority 04.09.89.

 5. Komarov F.I., Zaguskin S.L., Rapoport S.I. Chronobiological direction in medicine: biocontrolled chronophysiotherapy // Therapeutic apxiv. 8. - 1994. - C.3-6.

 6. Zaguskin SL. Biorhythmic biofeedback. // Chronobiology and chronomedicine, second edition edited by F.I.Komarov and S.I. Rapoport. M .: Triad-X., 2000. S.317-328.

 7. Zaguskin S. S., Oraevsky V. P., Rapoport S. I. The method of selective destruction of cancer cells. // RF patent 2147847 according to application 99109270, priority 06.05.1999.

 8. Zaguskin SL., Kogan AB, Leader VV, Rozhansky VN The use of an electronic probe for microanalytical determination of the localization of chemical elements in the cell. //Cytology. - 1967. - T. IX, 6, - C. 741-746.

Claims (5)

 1. The biosynchronization system of physiotherapeutic and destructive processes of influence, comprising a pulse sensor connected through the first amplifier to the input of the first control unit, the output of which is connected to the control input of the first switch, a breathing sensor connected through the second amplifier to the input of the second control unit, the output of which is connected to the control input of the second switch, and the first and second switches are connected in a series circuit between the output of the physiotherapeutic or destructive source Processes and impact object impacts or are arranged to overlap or sequential flow deflection physiotherapeutic impact or destructive process using appropriate mechanical shutter or chopper.  2. The system according to claim 1, characterized in that the first control unit comprises a series-adjustable adjustable delay element and a NOT element shunted by a key, and a two-position switch, the input of the delay element being an input of the first control node, the output of the element is NOT connected to the opening contact of the two-position a switch, a closed contact of which is connected to the bus of the source of the unlocking potential, and the movable contact is the output of the first control unit.  3. The system according to claim 1, characterized in that the second control unit contains an element NOT shunted by a key and a two-position switch, wherein the input of the element is NOT an input of a second control node, to the output of which a movable contact of the on-off switch is connected, the disconnected contact of which is connected to the output of the element is NOT, and the contact being closed is to the bus of the unlocking potential source.  4. The system according to claim 1, characterized in that each switch contains an electromagnetic relay for acting on a mechanical chopper or curtain.  5. The system according to claim 1, characterized in that each switch contains an electromagnet for deflecting the flow of a physiotherapeutic or destructive exposure process.

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