TW567078B - Electromagnetic apparatus of treatment of lesions associated with inadequate blood perfusion, partial denervation, tissue loss, pain, edema, inflammation and infection - Google Patents
Electromagnetic apparatus of treatment of lesions associated with inadequate blood perfusion, partial denervation, tissue loss, pain, edema, inflammation and infection Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/008—Magnetotherapy specially adapted for a specific therapy for pain treatment or analgesia
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Abstract
Description
567078 A7 B7 五、發明説明(1 ) t明背景 發明範圜 本發明通常係有關於用於例如除了低灌注心肌之外可復 原的皮膚傷害與内傷治療之裝置。更明確而言,本發明係 有關透過只單獨將時變電磁場或同時使用靜磁場投予在特 殊身體上來治療受不足血液灌注、组織喪失、部份去神經 支配、傷害、骨折、跛足、及/或潰傷疼痛的一身體之裝置 〇 背景描述 局部運用電磁場(EMFs)已顯示可在皮膚傷害復原期間, 增加皮膚與神經纖維再生、生膠質細胞形成與張力。電磁 力亦顯示可導致纖維組織母細胞與促進血管生成繁殖與生 膠質促成的提供。此外,局部應用的電磁力長久已認為可 促使柔嫩組織自動恢復。慢性靜脈腿潰瘍與壓迫潰瘍可透 過各種不同的,療應用醫治,包括可直接運用在潰傷部位 的生長因素、鬲比重氧、局部紅外線照射、電磁力、紫外 線與低能量雷射、及超音波局部應用。然而,^國健康服 務部門的健保政策與研究機構建議局部應用電磁力,作為 可充L支援壓边潰瘍治療蹟象的唯一輔助治療法。雖然電 磁力的局部應用可用來治療慢性靜脈腿潰瘍、神經纖維再 生:骨折,及保護因惱怒而局部貧血後遺症的動物模式, 但是所有嘗試可在遠離受疼痛部位的點上運用電磁力治療 在現階段已告失敗。 、 在獲得病情改善日寺,不要在傷害部位施用冑磁力來治療 O:\65\65722-910515 〇〇〇\ -4-567078 A7 B7 V. Description of the invention (1) Background of the invention The invention generally relates to devices for the treatment of skin injuries and internal injuries that can be restored, for example, in addition to hypoperfusion myocardium. More specifically, the present invention relates to the treatment of inadequate blood perfusion, tissue loss, partial denervation, injuries, fractures, lame feet, by using a time-varying electromagnetic field alone or simultaneously using a static magnetic field on a particular body. And / or a body device for ulcer pain. Background Description Local application of electromagnetic fields (EMFs) has been shown to increase skin and nerve fiber regeneration, glia cell formation and tension during skin injury recovery. Electromagnetic forces have also been shown to lead to fibroblast mother cells and promote angiogenic reproduction and the provision of glial growth. In addition, locally applied electromagnetic forces have long been thought to promote the automatic recovery of soft tissues. Chronic venous leg ulcers and compression ulcers can be treated through a variety of therapeutic applications, including growth factors that can be directly applied to the wound site, radon specific gravity, local infrared radiation, electromagnetic force, ultraviolet and low energy lasers, and ultrasound Local application. However, the health care policy and research institute of the National Health Service Department of China recommended the topical application of electromagnetic force as the only adjuvant treatment that can be used to support signs of edge ulcer treatment. Although topical application of electromagnetic force can be used to treat chronic venous leg ulcers, nerve fiber regeneration: fractures, and animal models that protect against the sequelae of local anemia due to irritation, all attempts can be made using electromagnetic force therapy at a point away from the site of pain The phase has failed. 、 When getting the condition improvement day temple, do not apply magnetic force to the injured part to treat O: \ 65 \ 65722-910515 〇〇〇 \ -4-
害及J0L伯I — 幫助,特此對甚至在整個復原傷#將會有較大的 感到不使*疋污害邵位某程度不受影響,或只避免病人 日’。在免費醫療訓練人員供治療診斷與處方及追 =何特殊應用上所獲得的結果方面,此治療可投予在一 、丙人而播需鬲度技術者,而且可減少治療成本。 i此很清楚需要用以加速及促進一身體傷害復原之一 改,万法,特別是抗拒其他較傳統治療的傷害,對於由一 2熟諳此技人員在門診病人身體上是不方便,而且給病人 T來不便。此治療明顯可治療且經濟有效。 發明概述 、、本發明係有關治療傷害、燙傷、皮膚潰瘍、及除了低灌 肌之外可復原之裝置,其包含在付諸實應用傷害、燙 傷、情況下,骨頭或潰瘍復原情況下,在從要移除傷害部 位上將特殊外部及非侵入超低頻電磁場(EMFs)運用在受一 傷害燙傷與潰瘍疼痛之一身體,以提高血管生成及脈管生 成’及改善其他隨後應用治療的效果。適當的電磁力包含 在數赫兹(超過1)至小於約300赫茲頻率上所產生的一時變 電磁場元件及大約數個微磁通量密度的靜磁場元件,例如 ’大約2-5 μΤ、大約20 μΤ至大約100 μΤ、大約0.3 mT、 大約0 ·8 mT。這些電磁力可獨自或與大約4 〇、大约5 〇至大 約7〇、大約80 mT (或大約400、大約500至大約700、大約 800高斯)的一同質靜磁場結合使用。雖然在某些情況,線 圈内部的測量頻率是大約〇 . 3至大約0·8 μΤ,在接近而非線 圈内部的皮膚區域,電磁力的強度可降到周圍的磁場下。 O:\65\65722-910515 D〇C\ 4 -5- :明的方法特別適於受到例如燙傷的皮膚傷害、例如 if ί、部份去神經支配與溃瘍,特別是例如靜脈與動 壓迫料、未祕傷害、感染傷害、疼痛發炎 足1…殊^性傷害、例如除了低灌m等可復原的不 硬准注區域疼痛之身體有療效治療,這些可 合例如動脈硬化、曲張靜脈、糖尿病* " #火 叫依苽脈糖尿病、同血壓、風濕性關 即火、外傷等的其他原因出^見。一些傷害會抗拒或無法反 …卜^或保+的傳統方法治療,但是現階段的治療投予使 他們可高度反應先前無效的治療。本方法可短暫投予及週 期將一治療的身體在一段時間重複治療,用以減少疼痛、 =腫、發炎與感染、逐漸增加血管生成、脈管生成、神經 纖維再生、#質接合、&重建身體免疫抗發炎反應與傷害 復原處置。 、^ 本治療方法可明顯減少先前高度抗拒其他傳統醫療身體 的復原時間。 κ 本發明將透過隨後描述的各種不同圖與數個範例詳細描 述。 圖式之簡單說明 有兩較佳方法可使一身體部位暴露在本發明的磁場。第 一方法係利用將時變磁場與靜磁場結合之一設計。有關第 一設計之本發明裝置的兩不同具體實施例可提供給此目的 使用。 該等裝置設計的第一具體實施例是在圖1至7描述。 圖1係描述從外部看出的本發明裝置之一部份簡化透視圖 O:\65\65722-910515 DOC\ 4 -6- 567078 A7 B7 五、發明説明(4 ) 圖2係描述在圖1所示裝置之一部份透視及截面圖。 圖3係顯示透過根據本發明所產生的可變與靜磁場結合而 產生一磁通量圖式。 圖4係透過本發明裝置的所有具體實施例電路而顯示由提 供線圈電流所產生的一波形圖式。 圖5係顯示透過本發明裝置的所有具體實施例所產生的電 磁信號頻率分配圖式。 圖ό是如圖2所示在螺線圈與永久磁鐵内部所延伸之一臂 簡化上視圖。 圖7係供激勵本發明裝置的螺線圈之一電源供應電路圖。 本發明裝置的第一設計之第二具體實施例是在圖8至1 〇顯 示。此具體實施例是在圖1和2所示第一具體實施例的一放 大圖式。 圖8係描述將身體暴露在電磁力的一本發明裝置透視圖。 圖9係描述在圖8所示裝置的一側視圖。 本發明裝置的一第二設計只將身體部位暴露在時變磁場 。本發明裝置的5個不同具體實施例可用於此目的範例。 五個具體實施例之其中第一者是在圖10至13顯示。在此 具體實施例中,上述裝置的永久磁鐵可去除,而其他元件 保持不變。 圖1 0係描述從外部看出的本發明裝置之一部份簡化透視 圖。 圖11係描述在圖10所示裝置的一部份透視及截面圖。 O:\65\65722-910515.DOC\ 4 本紙張尺度適用中國國家標準(CNS) Α4規格(210 X 297公釐) 567078 A7Harm to JOLL — I help, and hereby I feel that even in the whole recovery injury # will have a larger feeling that will not stain the Shao bit to some extent, or just avoid the patient's day ’. In terms of free medical training for treatment diagnosis and prescription and the results obtained by special applications, this treatment can be administered to people who need advanced technology and reduce the cost of treatment. It is clear that it is necessary to accelerate and promote the recovery of a bodily injury. Methods, especially resistance to other more traditional treatments, are inconvenient for a skilled person in the outpatient body, and give Patient T is inconvenient. This treatment is clearly treatable and cost effective. SUMMARY OF THE INVENTION The present invention relates to a device for treating injuries, burns, skin ulcers, and recoverable devices other than low irrigated muscles, which includes the actual application of injuries, burns, and cases where bones or ulcers are restored. Special external and non-invasive ultra-low frequency electromagnetic fields (EMFs) are applied to the body from which the injury is to be removed in order to improve angiogenesis and angiogenesis' and improve the effectiveness of other subsequent treatments. Appropriate electromagnetic forces include a time-varying electromagnetic field element generated at a frequency from a few hertz (more than 1) to less than about 300 hertz and a static magnetic field element of about several micro-magnetic flux densities, such as' about 2-5 μT, about 20 μT to Approximately 100 μT, approximately 0.3 mT, approximately 0.8 mT. These electromagnetic forces can be used alone or in combination with a coherent static magnetic field of about 40, about 50 to about 70, about 80 mT (or about 400, about 500 to about 700, about 800 Gauss). Although the measurement frequency inside the coil is about 0.3 to about 0.8 μT in some cases, the intensity of the electromagnetic force can be reduced to the surrounding magnetic field in the area of the skin close to but not inside the coil. O: \ 65 \ 65722-910515 D〇C \ 4 -5-: The clear method is particularly suitable for skin injuries such as burns, such as if, partial denervation and ulcers, especially for example veins and dynamic compression materials , Non-secreted injury, infection injury, pain and inflammation foot1 ... special injury, for example, in addition to low irrigation m and other recoverable non-hard quasi-injection area pain in the body has effective treatment, these can be combined such as arteriosclerosis, varicose veins, diabetes * "#Fire is called Diabetes, diabetes, blood pressure, rheumatism, fire, trauma and other reasons ^ see. Some injuries may be resisted or irreversible… or the traditional method of treatment, but the current stage of treatment administration makes them highly responsive to previously ineffective treatments. The method can be administered for a short period of time and the treatment body is repeatedly treated for a period of time to reduce pain, swelling, inflammation and infection, gradually increase angiogenesis, angiogenesis, nerve fiber regeneration, #plasmid junction, & Reconstruct the body's immune anti-inflammatory response and injury recovery treatment. , ^ This treatment method can significantly reduce the recovery time of previously highly resistant other traditional medical bodies. κ The present invention will be described in detail through various figures and several examples described later. BRIEF DESCRIPTION OF THE DRAWINGS There are two preferred methods for exposing a body part to the magnetic field of the present invention. The first method is to design using one of a combination of a time-varying magnetic field and a static magnetic field. Two different embodiments of the device of the invention of the first design can be provided for this purpose. A first specific embodiment of such a device design is described in FIGS. 1 to 7. Figure 1 depicts a simplified perspective view of a part of the device of the present invention as seen from the outside O: \ 65 \ 65722-910515 DOC \ 4 -6- 567078 A7 B7 V. Description of the invention (4) Figure 2 is depicted in Figure 1 Part of the device shown is a perspective and cross-sectional view. Fig. 3 is a diagram showing a magnetic flux generated by combining a variable and static magnetic field generated according to the present invention. Fig. 4 is a diagram showing a waveform generated by supplying a coil current through the circuits of all embodiments of the device of the present invention. Fig. 5 is a diagram showing the frequency distribution of electromagnetic signals generated by all the specific embodiments of the device of the present invention. Figure 6 is a simplified top view of an arm extending inside the spiral coil and the permanent magnet as shown in Figure 2. FIG. 7 is a power supply circuit diagram of one of the solenoids for exciting the device of the present invention. A second specific embodiment of the first design of the device of the present invention is shown in Figs. 8 to 10. This specific embodiment is an enlarged view of the first specific embodiment shown in Figs. Figure 8 is a perspective view depicting a device of the present invention that exposes the body to electromagnetic forces. FIG. 9 is a side view of the device shown in FIG. 8. FIG. A second design of the device of the present invention only exposes the body part to a time-varying magnetic field. Five different specific embodiments of the device of the invention can be used as examples for this purpose. The first of the five specific embodiments is shown in FIGS. 10 to 13. In this embodiment, the permanent magnets of the device described above are removable, while the other components remain unchanged. Fig. 10 is a simplified perspective view illustrating a part of the apparatus of the present invention as seen from the outside. FIG. 11 is a perspective and cross-sectional view of a portion of the device shown in FIG. 10. O: \ 65 \ 65722-910515.DOC \ 4 This paper size applies to China National Standard (CNS) Α4 size (210 X 297 mm) 567078 A7
圖1 2係根據本發明而顯示由時變磁場所產生的一電磁通 量圖式。 圖13是在如圖11所示線圈的該等磁線圈之間所延伸的一 臂簡化上視圖。 五個具體實施例之其中第二者是在圖14至16顯示。這是 在圖1 0至圖1 3所示具體實施例的一簡化圖式。 圖14係描述從外部看出的本發明裝置之一簡化透視圖。 圖1 5係描述在圖1 4所示裝置的一部份透視與截面圖。 圖1 6是例如在圖1 5所示線圈的該等磁線圈之間所延伸的 一臂簡化上視圖。 五個具體實施例之其中第三者是在圖17和18顯示,而且 是在圖1 0至圖1 3所示具體實施例的一放大圖式。 圖1 7係描述一身體暴露電磁力的一本發明裝置側視圖。 圖18描述在圖17所示裝置的一透視圖。 在本發明裝置的五個具體實施例之其中第四者中,本發 明的時變磁場可透過兩Hemholtz線圈產生。 圖1 9至2 3係描述此具體實施例。 圖1 9係描述從外部看的本發明裝置的一簡化透視圖。 圖2 0係描述在圖1 9所示裝置的一透視與截面圖。 圖2 1係根據本發明而顯示由時變磁場所產生的一電磁通 景圖式。 圖2 2係顯示在圖1 9所示裝置磁線圈之間所延伸的一簡化 透視圖。 圖2 3係描述在圖2 2所示裝置的該等磁線圈之間所延伸的 O:\65\65722-910515.DOC\ 4 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐) -8 - 裝 訂Fig. 12 is a diagram showing an electromagnetic flux generated by a time-varying magnetic field according to the present invention. FIG. 13 is a simplified top view of an arm extending between the magnetic coils of the coil shown in FIG. 11. FIG. The second of the five specific embodiments is shown in Figs. This is a simplified diagram of the specific embodiment shown in FIGS. 10 to 13. Figure 14 depicts a simplified perspective view of one of the devices of the invention as seen from the outside. FIG. 15 is a perspective and sectional view of a portion of the device shown in FIG. 14. Fig. 16 is a simplified top view of an arm extending between the magnetic coils of the coil shown in Fig. 15, for example. A third one of the five specific embodiments is shown in Figs. 17 and 18, and is an enlarged view of the specific embodiments shown in Figs. 10 to 13. Figure 17 is a side view of a device of the present invention depicting a body exposed to electromagnetic forces. FIG. 18 depicts a perspective view of the device shown in FIG. In a fourth of the five specific embodiments of the device of the present invention, the time-varying magnetic field of the present invention can be generated through two Hemholtz coils. Figures 19 to 23 describe this embodiment. Fig. 19 is a simplified perspective view illustrating the device of the present invention as viewed from the outside. FIG. 20 is a perspective and sectional view of the device shown in FIG. 19. Fig. 21 shows an electromagnetic view pattern generated by a time-varying magnetic field according to the present invention. Fig. 22 shows a simplified perspective view extending between the magnetic coils of the device shown in Fig. 19. Figure 2 3 describes the O: \ 65 \ 65722-910515.DOC \ 4 extending between the magnetic coils of the device shown in Figure 2 2 This paper size applies to China National Standard (CNS) A4 (210 X 297) Mm) -8-Staple
線 567078 A7 ____B7 五、發明説明(6 ) 一身體簡化透視圖,其中該裝置是上下顛倒放置,而且固 定在床上。 圖2 4是用來激勵本發明裝置的磁線圈之一電源供應電路 圖式。 裝置的第五具體實施例是在圖2 5至2 8顯示。在此具體實 施例中,本發明的時變磁場是透過在一凹處所配置的線圈 而產生。 圖2 5係描述從外部看出的一本發明裝置簡化透視圖。 圖26係描述在圖25所示裝置的一部份透視與截面圖式。 圖2 7係根據本發明而顯示由時變磁場所產生的一電磁通 量圖式。 圖2 8是例如在圖2 6所示裝置線圈的該等磁線圈之間所延 伸的一動物肢體簡化透視圖。 圖2 9係顯示從正常物體獲得週邊血液單核白血球細胞 (PBMCs)擴散上的磁場影響。透過無電磁力影響細胞分裂 的PMBCs擴散激勵可ι00%採用。結合靜態與時變磁場的影 響可在PBMCs擴散(透過gtudent “丁,,測試ρ〈〇·〇〇ι)產生一 11 · 1 %增加。只有靜磁場在PBMCs的擴散上沒有統計上的明 顯影響。 本發明的先前及其他目的與特徵可從下列本發明及附圖 的詳細描述變得更明白。 趁體實施例之詳細說明 從發明家的一想要起源的本發明可改良先前技藝技術及 各種不同效果的不顯著有療效治療,此外,需要直接投予 O:\65\65722-910515.DOC\ 4 本紙張尺度適财8 S家標準(CNS) A4規格(21G χ 297公爱) 567078 A7 B7 五、發明説明(7 ) ----- 在傷害部位。這會使病人厭惡,不容易實行,且明顯告 不便。 成 本發明家令人驚訝發現到,當慢性皮膚傷害或例如骨折 内傷、部份去神經支配、或除了低灌注心肌之外可復^的 一身體根據本發明將一電磁場(EMFs)運用在一部份身體户 療時,傷害會顯示刺激發炎反應及傷害復原;結果,傷堂 會明顯及迅速減少,而且在許多情況,可迅速復原及/戈二 全去除。此情況可甚至用在抗拒其他通常有效治療的^堂 。根據本發明,在除了低灌注心肌之外的可復原,電磁; 可運用在一部份身體上,產生較佳臨床改善所示增加附帶 循環和心肌收縮。發明家所獲得的利益可透過在例如手= 、手、腿、或腳身體肢體部位上實施,或甚至將整個身體 暴露在具有特殊固定與可變元件之特殊電磁場(EMFs)實= 。臨床經驗的問題是内部及外部傷害的一些身體可在一杧 時間在他們身上投予藥物及其他有效療法的治療。此外, 其他傷害、内傷、低灌注組織、燙傷、與潰瘍會對這些治 療無反應。 本發明家令A驚訏發現到當根據本發明將此身體暴露在 外部非侵入電磁場(EMFs)時,他們變成可反應先前無效的 治療,例如已知的傷害治療藥物及其他治療。可從本治療 獲益的許多身體有急性心肌梗塞、靜脈或動脈腿潰癌、烫 傷、壓迫潰瘍、外科感染傷害、骨折、組織喪失、部份去 神經支配、不足的血液灌注、及疼痛發炎軟性組織等病歷 ’其可抗拒或不反應外科、藥物、或較傳統方法的可用治 O:\65\65722-910515 DOC\ 4 -10-Line 567078 A7 ____B7 V. Description of the invention (6) A simplified perspective view of the body, in which the device is placed upside down and fixed on the bed. Figure 24 is a diagram of a power supply circuit for a magnetic coil used to excite the device of the present invention. A fifth specific embodiment of the device is shown in Figs. In this embodiment, the time-varying magnetic field of the present invention is generated by a coil disposed in a recess. Figures 25 and 5 illustrate a simplified perspective view of an apparatus of the invention as seen from the outside. FIG. 26 is a perspective and sectional view of a portion of the device shown in FIG. 25. FIG. Fig. 27 is a diagram showing an electromagnetic flux generated by a time-varying magnetic field according to the present invention. Fig. 28 is a simplified perspective view of an animal limb extending between the magnetic coils of the device coil shown in Fig. 26, for example. Figure 29 shows the influence of magnetic fields on the diffusion of peripheral blood mononuclear leukocytes (PBMCs) obtained from normal objects. PMBCs with non-electromagnetic force affecting cell division can be used at 00%. Combining the effects of static and time-varying magnetic fields can result in an 11.1% increase in the diffusion of PBMCs (through gtudent, D, test ρ <〇〇〇〇ι). Only the static magnetic field has no statistically significant effect on the diffusion of PBMCs. The previous and other objects and features of the present invention will become more apparent from the following detailed description of the present invention and the accompanying drawings. Detailed description of the embodiments There are not significant effective treatments for various effects. In addition, it needs to be directly administered to O: \ 65 \ 65722-910515.DOC \ 4 This paper is suitable for financial standards 8 S family standards (CNS) A4 specifications (21G χ 297 public love) 567078 A7 B7 V. Description of the invention (7) ----- In the area of injury. This will make patients sick, not easy to implement, and obviously inconvenient. Costs The inventors have surprisingly found that when chronic skin injuries or internal injuries such as fractures A body that is partially denervated or that can be restored in addition to hypoperfusion myocardium. When an electromagnetic field (EMFs) is applied to a part of the body according to the present invention, the injury will show stimulation of inflammatory response and injury recovery; As a result, the injury hall will be significantly and rapidly reduced, and in many cases, it can be quickly restored and / or removed completely. This situation can even be used to resist other commonly effective treatments. According to the present invention, in addition to low perfusion myocardium Externally recoverable, electromagnetic; can be applied to a part of the body to produce better clinical improvement as shown by increasing collateral circulation and myocardial contraction. The benefits obtained by the inventors can be achieved by, for example, the hand =, hand, leg, or foot body On limbs, or even exposing the entire body to special electromagnetic fields (EMFs) with special fixed and variable elements. The problem with clinical experience is that some bodies that are internally and externally injured can be administered to them in a matter of seconds. Drugs and other effective therapies. In addition, other injuries, internal injuries, hypoperfusion tissues, burns, and ulcers will not respond to these treatments. The inventor of the present invention surprised A to discover that when the body is exposed to the outside according to the present invention When non-invasive electromagnetic fields (EMFs), they become responsive to previously ineffective treatments, such as known injury treatment drugs and other treatments. Many of the bodies that benefit from treatment include acute myocardial infarction, venous or arterial leg ulceration, burns, compression ulcers, surgical infection injuries, fractures, tissue loss, partial denervation, insufficient blood perfusion, and painful and inflamed soft tissue. Medical record 'which can resist or not respond to the available treatments of surgery, medicine, or more traditional methods O: \ 65 \ 65722-910515 DOC \ 4 -10-
567078 A7567078 A7
本發明可利用特殊電 在要移除傷〜 U “场_Fs),其可有利運用 上的•磁力:’邵位。雖然在暴露身體組織的其他電磁力 力動作未消除,但是本電磁力可刺激—身體免疫 ' 匕括及理想對象是身體受刺激與記憶週邊血單核白 :球細胞(_)。身體免疫系統之一活性化會造成」自 然反應’以使用必要的細胞、細胞漿、血管性、骨生成與 神、1生長因素、荷爾蒙及其他免疫調變器來提供免疫神經 :分泌腺調節的傷害部纟及其他㈣,其會帶來有關例= 傷害傷害、靜脈與動脈腿潰瘍、壓迫潰瘍、慢性感染、例 如除了低灌注心肌等可復原之外的不足血液灌注的内部或 外部區域、肌肉損失、骨折、部份去神經支配、疼痛發炎 軟性組織、及其他皮膚傷害之有療效的治療。本發明的電 磁場(EMFs)係包含時變磁場,亦即在指定頻率振盪的交流 電。在本發明的一具體實施例中,交流電範圍是從數赫茲( 超過每秒1週期)、大約1 〇赫茲、大約5 〇赫茲到1〇〇赫茲、 大約200赫茲、大約3〇〇赫茲範圍頻率的一螺線圈中產生, 其具120赫茲及其諧波附近的最大強度。參可圖5有關此病 人。這些時變磁場具有從數個微磁通量的小靜磁場,例如 大約2-5 μΤ、大約10 μΤ至大約100 μΤ、大约〇·3、大約〇.8 mT。具大約4 0、大約5 0至大約6 0 μΤ、大約7 〇 μτ、大約8 〇 mT (400到800高斯)強度的強靜磁場是在螺線圈附近所放置 本發明的永久磁鐵内之原子附近的電子及晶格的移動而產 生0 O:\65\65722-910515 DOC\ 4 本紙張尺度適用中國國家標準(CNS) A4規格(210X 297公ϋ 裝 訂 線 -12- 567078 五、發明説明( 可直接或藉由免疫細胞或其他暴露組織或藉著細 月已的生成物來達成_傷堂 切害組織的復原,而且在自動復原或 刺激品增加血管生成祕其 脈管生成、及傷害復原的身體免疫 _解特徵網狀組織睡, * 、 、’ ,了減疼蹋、水腫、與感染。當例 手或正個身體的一部位暴露在本發明的ENTs時,例如 皮膚肌肉、血液與淋巴管、紅血球、骨頭、神經與額外 、肊母的PBMCs及其他組織是在本發明的EMFs影響下。 ^些情況’同時暴露的組織可受刺激,以便從傷害、低 灌注組織、部份去神經區域、骨折復原、或促成傷害復原 調節的免疫神經内分泌腺中心—段距離上分泌生成物。 因此,本發明係有關治療一身體傷害之方法,這些身體 傷菩是與疼痛、水腫,發炎、骨折、部份去神經支配及,或 感染、傷菩傷菩復原及/或例如除了低灌注心肌等之外可復 原的低灌注組織、傷害部位的不足血液灌注、及/或出現一 傷害免疫調解炎症反應及傷害復原處置有關,其包含應用 在受一傷害疼痛、外部與非侵入及在要去除傷害部位的一 身體,止痛劑、血管性、脈管發生、神經纖維生長、抗水 腫、及傷害復原有效電磁場(EMFs)包含數赫兹頻率,理想 是大約0 . 1赫茲、大約1赫茲、大約5赫茲、大約1 〇赫茲、 大約2 0赫茲、大約6 0赫茲、大約8 0赫茲、大約1 〇〇赫茲、 大約120赫茲到小於約180赫茲、大約240赫茲、大約300赫 茲;及靜磁場元件,其具有數微磁通量密度的最小強度, 例如大約2 - 4 μ T、大約1 〇 μ T、大約5 0 μΤ、大約100 μ T 至大約0 · 3、大約〇 · 4、大約0 · 5、大約〇 · 6、大約〇 · 7、大 O:\65\65722-910515 DOC\ 本紙張尺度適用中國國家標準(CNS) A4规格(21〇 x 297公釐) 裝 訂 線 567078 A7 ___B7 五、發明説明(1〇 ) 約0.8 mT。這些電磁力可單獨或與大約4 〇、大約5 〇至大約 70、大約80 mT(或大約400、大約450、大約5〇〇、大約550 高斯至大約600、大約650、大約700、大約8〇〇高斯)的靜磁 場結合使用。 在本發明的方法中,電磁力可運用在一身體肢體、一手 臂或一腿、及在某些情況,可運用在一手或一足、身體其 他部位、或整個身體。本方法可隨時進行,包括每次大約5 分鐘至大約7小時投予。在一較佳具體實施例中,電磁場 (EMFs)投予可進行一段時間,以便將身體整個血液量至少 一次暴露在電磁力。此程序可確保整個血液量暴露在電磁 力及感應效果送給在血流出現的所有細胞,特別受刺激與 記憶週邊血液單核白血球細胞、及其早先細胞。雖然在許 多情況,電磁場(EMFs)的一應用可滿足,但是應用可依需 要重複多次。理想上是一週一次、一週兩次、一週3、4、5 、6、和7次,且多達大約i、2、3、4、5、6、7和8週, 而且甚至可數月與數年。此外,該方法亦包括電磁力的週 期重複應用。 本發明的方法可利在由—身體傷害科歧/或造成及/ 或有關的疾病與情況的治療。在所有的情況中,一足夠量 的電磁場(EMFs)應用可實施,直到傷害減輕及/或完全復原 為止。可使用目前技術治療的傷害是慢性傷害、部份去神 經支配 '肌肉組織損失、骨折、烫傷、由不足的血液灌注 所造成的傷害、例如除了低道泞里、 陡了低准,王心肌等又外的可復原、未 成功的外科手術結果、及不同*刑德 ^ ^穎土靜脈、動脈與脈管問題 O:\65\65722-910515.DOC\ 4 -13-The present invention can use special electricity to remove the wound ~ U "field_Fs), which can be beneficially applied. Magnetic force: 'Shao bit. Although other electromagnetic force actions in exposing body tissues have not been eliminated, but this electromagnetic force Stimulation-Body Immune 'The ideal target is the body's stimulated and memorized peripheral blood mononuclear white cells: globular cells (_). Activation of one of the body's immune systems will cause a "natural reaction" to use the necessary cells and cytoplasm , Vascularity, osteogenesis and growth, 1 growth factors, hormones and other immune modulators to provide immune nerves: secretory glands regulate the injury part 纟 and other ㈣, which will bring related examples = injury injury, veins and arterial legs Ulcers, compression ulcers, chronic infections, such as internal or external areas with insufficient blood perfusion in addition to recoverable hypoperfusion myocardium, muscle loss, fractures, partial denervation, pain and inflammation of soft tissues, and other skin injuries Effective treatment. The electromagnetic fields (EMFs) of the present invention include time-varying magnetic fields, that is, alternating currents that oscillate at a specified frequency. In a specific embodiment of the present invention, the AC power range is a frequency from a few hertz (over 1 cycle per second), about 10 Hz, about 50 Hz to 100 Hz, about 200 Hz, and about 300 Hz. Produced by a spiral coil with a maximum intensity near 120 Hz and its harmonics. See Figure 5 for this patient. These time-varying magnetic fields have small static magnetic fields from several micro-magnetic fluxes, such as about 2-5 μT, about 10 μT to about 100 μT, about 0.3, about 0.8 mT. A strong static magnetic field with a strength of about 40, about 50 to about 60 μT, about 70 μτ, and about 80 mT (400 to 800 Gauss) is near the atoms in the permanent magnet of the present invention placed near the spiral coil. 0 O: \ 65 \ 65722-910515 DOC \ 4 This paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X 297 public binding line-12- 567078) V. Description of the invention (may It can be achieved directly or through immune cells or other exposed tissues or through the products of fine moons. _______________ The recovery of wounded tissues, and the auto-recovery or stimulants increase angiogenesis, angiogenesis, and damage recovery. Physical Immunity_Solution Features Reticulated tissue sleep, *,, ', reduce pain, edema, and infection. When a hand or a part of the body is exposed to the ENTs of the present invention, such as skin muscles, blood and lymph Tubes, red blood cells, bones, nerves, and extra-maternal PBMCs and other tissues are under the influence of the EMFs of the present invention. ^ Some conditions' Tissues exposed at the same time can be stimulated in order to reduce injury, hypoperfusion tissue, partial denervation Area , Fracture recovery, or immune neuroendocrine glands that contribute to the regulation of injury recovery, secrete products at a distance. Therefore, the present invention relates to a method for treating a physical injury. These physical injuries are related to pain, edema, inflammation, fracture, Partial denervation and, or infection, wound healing, and / or hypoperfusion tissue that can be restored in addition to hypoperfusion myocardium, insufficient blood perfusion at the injury site, and / or a damaging immune-mediated inflammatory response Related to injury recovery treatment, which includes application to an injured pain, external and non-invasive and a body where the injury is to be removed, analgesics, vascularity, angiogenesis, nerve fiber growth, anti-edema, and injury recovery effective Electromagnetic fields (EMFs) contain several hertz frequencies, ideally about 0.1 Hz, about 1 Hz, about 5 Hz, about 10 Hz, about 20 Hz, about 60 Hz, about 80 Hz, about 1000 Hz , About 120 hertz to less than about 180 hertz, about 240 hertz, about 300 hertz; and a static magnetic field element that has a few micro-fluxes Minimum intensity, such as about 2-4 μT, about 10 μT, about 50 μT, about 100 μT to about 0.3, about 0.4, about 0.5, about 0.6, about 〇 7. Big O: \ 65 \ 65722-910515 DOC \ This paper size is applicable to China National Standard (CNS) A4 (21〇x 297 mm) Gutter 567078 A7 ___B7 5. Description of the invention (1〇) about 0.8 mT. These electromagnetic forces can be used alone or with about 40, about 50 to about 70, about 80 mT (or about 400, about 450, about 500, about 550 Gauss to about 600, about 650, about 700, about 800 Gauss) combined with a static magnetic field. In the method of the present invention, electromagnetic force can be applied to a body limb, an arm or a leg, and in some cases, it can be applied to a hand or a foot, other parts of the body, or the entire body. The method can be performed at any time and includes administration of about 5 minutes to about 7 hours each time. In a preferred embodiment, electromagnetic field (EMFs) administration can be performed for a period of time to expose the entire blood volume of the body to electromagnetic forces at least once. This procedure ensures that the entire blood volume is exposed to electromagnetic forces and induction effects to all cells present in the bloodstream, especially stimulated and memorized peripheral blood mononuclear leukocytes and their earlier cells. Although an application of electromagnetic fields (EMFs) is sufficient in many cases, the application can be repeated as many times as necessary. Ideally once a week, twice a week, 3, 4, 5, 6, and 7 times a week, and up to about i, 2, 3, 4, 5, 6, 7, and 8 weeks, and even months and months Years. In addition, the method also includes the repeated application of electromagnetic forces. The method of the present invention may be beneficial in the treatment of diseases and conditions caused by-and / or caused by, physical injury. In all cases, the application of a sufficient amount of electromagnetic fields (EMFs) can be implemented until the injury is mitigated and / or fully recovered. Injuries that can be treated using current technology are chronic injuries, partial denervation, loss of muscle tissue, fractures, burns, injuries caused by insufficient blood perfusion, such as in addition to the lower canal, steeper, lower precision, and cardiac muscle Recoverable, unsuccessful surgical results, and other differences * Xingde ^ ^ Venous, arterial, and vascular problems O: \ 65 \ 65722-910515.DOC \ 4 -13-
567078 A7 B7 五、發明説明(”) "" —--- G 2動脈與靜脈旧瘍。各種不同傷害及其描述的範例、 ‘可用的各種不同其他治療及某些程度或不能成功克 服的疾病與狀況會在下面提供。 慢性靜脈斑會7脈腿考考— !· 1性靜脈腿清瘟 ^初,慢⑵靜脈Μ潰癌⑱常是由導致增加可走動壓力的 靜脈機能不全與活瓣失能。此效果可擴充到小血管、小靜 脈、、,毛^管的大部份情況。壓力會造成增大内皮間空間 ’接著提高小溶質的、巨分子與血細胞的外侵。此可視同 内皮組織的小與大分子及血細胞的漏損,並且送入組織間 隙的空間。可看到與此同時發生的淋巴血管疾病與減少的 淋巴排液,其造成減弱臨床水腫。慢速血流會形成,而且 内皮細胞層的白血細胞與血小板的黏著增加會導致微纖維 蛋白酵素的形成,其會出現毛細管數目減少。這些變化最 後會導致由纖維組織所取代的壞疽,壞疽會使靴區域的皮 膚易罹患潰瘍。 I· 1靜脈腿潰瘟治療 大多數巨血管變更傳統上可透過將腿舉起、外部分等壓 縮及/或外科程序治療。微血管變化可經使用例如最普遍指 示藥物的venotonic藥品、血小板凝集抗化劑、白血細胞活 動抗化劑與纖維蛋白溶解及溶解血栓劑之有系統藥物治療 °然而’目前沒有使人可信服的證據存,以建議可用於靜 脈腿潰瘍治療的這些藥劑。 II·慢性動脈腿浩瘟 O:\65\65722-910515 D〇C\ 4 -14-567078 A7 B7 V. Description of the invention (") G- 2 arterial and venous old ulcers. Examples of different injuries and their descriptions, 'Various other treatments available and to some extent or not successfully overcome The diseases and conditions will be provided below. Chronic venous plaques will be tested on 7 veins and legs—! · In the first stage, the venous leg will be cleared and the cancer will usually be caused by venous insufficiency caused by increased walking pressure. Valve disability. This effect can be extended to most cases of small blood vessels, small veins, and hair capillaries. Pressure will cause increased interendothelial space 'and then increase the invasion of small solute, macromolecules and blood cells. This can be seen as the leakage of small and macromolecules of the endothelial tissue and blood cells, and sent into the space between the tissues. It can be seen that the simultaneous occurrence of lymphovascular disease and reduced lymphatic drainage, which weakens clinical edema. Slow Blood flow is formed, and the increased adhesion of white blood cells and platelets in the endothelial cell layer results in the formation of microfibrinase, which reduces the number of capillaries. These changes eventually lead to Gangrene replaced by tissues, gangrene makes the skin of the boot area vulnerable to ulcers. I. 1 Venous leg ulcer treatment Most vascular changes are traditionally treated by lifting the leg, compressing the outer part, and / or surgical procedures Microvascular changes can be treated with systematic drugs such as venotonic drugs, the most commonly indicated drugs, platelet aggregation inhibitors, white blood cell activity inhibitors, and fibrinolytic and thrombolytic agents. However, 'at present there is no convincing Evidence exists to suggest these agents that can be used for the treatment of venous leg ulcers. II. Chronic Arterial Leg Holocaust O: \ 65 \ 65722-910515 D〇C \ 4 -14-
567078 A7 B7 五、發明説明(12 ) 在大部份情沉’下肢動脈硬化是動脈腿潰瘍的第一原因 ,而且它會導致動脈流明顯惡化變窄及末梢循環血流逐漸 減少。當疾病惡化時,動脈硬化傷害通常會擴大。當血流 完全變少且營養的毛細管灌注壓力不規則時,週邊微血管 循環的不足夠營養支持便會發生。此外,白血球粘著、血 小板凝集、血流變、與小動脈微纖維蛋白酵素的增加可看 到。這些有助進一步減少毛細管的數目。動脈改變在臨床 描述上是表示暫時疼痛、滋養性皮膚變化與潰瘍。此外, 這些傷害時常會受到感染。 II· 1慢性動脈腿潰瘍治療 出現的侵入治療係包括血管造形術、脈管復原與切除手 術。多數藥物治療著重在減少的疼痛及減少的感染。目前 ,嚴重腿局部貧血在全歐洲不建議對動脈腿潰瘍進行任 額外的藥物治療。 Ιπ· 1迫潰瘍(臥洛清瘟、 多數壓迫潰瘍會普遍產生,且不活動性會複雜化。在許 多例證2,他們會抗拒醫療。此抗拒會隨著營養失調、感 染、與高齡而明顯增加。這些潰瘍通常會增加病人死亡^ 危險性、在急性看謾醫院與安養院要維持一段較長的看護 寺門例如,在脊髓丈傷害病人方面,此問題會有7 _ 8 0/。 ^匕Ί然壓迫、摩擦、切力、與澄氣會牽連到皮膚崩 潰的發病,但是處置亦會受中度感染而惡化。 111,1 (臥姿潰瘍)治瘓 一最普通治療是以將病人復位開#,以避免身體任何特 〇:\65\65722-91〇515d〇c\ 4 紙張尺度_ A4#.i() ^297公釐) 567078 A7 _____B7 五、發明説明(13 ) 殊區域過度壓迫。此外,普遍運用在這些病人的基本治療 程序是一般性傷害照護,而且治療是要控制基本疾病。病 人亦建議要有適度的營養習慣,而且建議要獲得抗壞血酸 、鋅、與非金屬元素的補充物。 IV. 慢性傷害 在多數慢性傷害、不足營養的血供應、水腫、組織缺養 症的情況中’由老化與持續壓迫所增強的細胞死亡與感染 可在包含生長因素的細胞、荷爾蒙等、及在免疫神經内分 泌腺溝通網狀組織的效果之中減少縮氨酸特徵。由於缺乏 一正常免疫調解炎症反應及/或復原處理,所以復原會減弱 。目前可用的治療只部份有效,而且長期的預測對這些病 人是不佳。目前狀態強調需要新方法來治療慢性傷害,例 如活化傷害復原、神經纖維生長、脈管生成、與血管生成 所需細胞及細胞漿的特徵。 V. 心肌梗塞 動脈硬化是一般疾病,其會造成例如下肢動脈疾病(慢性 動脈腿潰瘍)、心肌梗塞、與脈搏的閉塞動脈疾病。病因因 素(動脈高血壓、高血漿膽固醇、抽菸、壓迫、糖尿病)是 類似這些疾病。有心肌梗塞病人的多數死亡是由心率不整 、梗塞擴張與後梗塞改變所引起。 V. 1心肌梗塞治瘓 預防“施疋肴重在去除或控制病因因素。心肌梗塞的初 期此亡率減少可在使用阻斷劑、溶解血检治療之後施行導 尿管再供應脈管、有或無擴張性之血管造形術、不經外科手 O:\65\65722-910515 D〇C\ 4 ·16- 本紙張尺度適用中國國家標準(CNS) Α4規格(210X297公釐) 術、血管緊縮素轉換酵素抗化劑、與阿斯匹林達成。對於 ,了低灌汪心肌之外可復原的不會成為冠狀動脈再供應脈 管的病人而言,血管性生長因素仍然是仍然在臨床研究的 一新方法。 VI.骨折 在骨折,斷裂復原的3個重疊階段已描述:a)類似一皮 膚傷害炎症期的炎症階段。b)修護階段,其中造骨細胞擴 散與骨内衣組織是皮膚硬化形成的中間。及c)改造階段, 其中斷裂皮膚硬化與骨頭會改造,以自願同意正常形狀與 強度。在斷裂的3個階段中,復原PBMCs與細胞漿是扮演一 中間角色。目則的治療係包括外科手術、固定、及局部將 電磁場運用使骨生成。 νπ·脊椎肌肉暮綠 幼年與孩重時期的脊椎肌肉萎縮是早期發病與遺傳的脊 髓運動肌神經原之一漸進退化疾病。雖然臨床類似肌肉營 養不良在這些病人中,肌肉萎縮對於神經纖維退化是衍 生的。在虛弱變成明顯之前,一些幼兒可正常發展數個月 。驅體、骨盤、與肩腰肌肉群會不均衡影響。疾病會穩定 下α行進,而且多數病人具有短時間壽命。一些可生存數 年,而且甚至可工作維持。現階段沒有可供這些疾病的治 療/σ療a限制復原療法與矯形術的幫助。神經纖維再生 的新方式疋神經病療因素,席凡(Schwann)細胞處置、及局 部應用電流或電磁場以感應電流,雖然這些治療不能用來 治療脊椎肌肉萎縮。 O:\65\65722-910515 DOCN 4 -17- 567078 五、發明説明(15 U扯k害有關的疾病和情況類型是例如部份去神 經ΐ:二組:喪失、烫傷、骨折、局部貧血與外傷性傷害 、k性傷害與潰瘍。經由更特殊的範例,下列疾病4; 由例如除了低灌注心肌等之外可復原: 不=液准注、組織壞疽、疼痛、水腫與感染所伴隨 T與;:;例如由動脈硬化、動脈高血壓、糖尿病、脈管 =靜脈機能不全、曲張靜脈、深血管检塞、風濕性 炎、擴及不活動性肥脾、祕其^、 所以μ, 壞叛、慢性傷害與惡化烫傷 ==邵與外部慢性傷害;由外傷、费傷與外科手術 =?:的情況’例如皮膚、肌肉、神經與二 ^•疋限制在除了低灌注心肌之外可復原的,例如靜 =昜臥姿潰癌、高度壓追潰癌、中度足踩 、脊椎肌肉萎縮等所產生的潰,;t!:命與下肢溃癌 位於身i?獅, °下肢潰癌是個別或整個 仏万;身⑽或㈣的不龍域。使用本方法㈣ 卜科:!非外科。通常非外傷是除了低灌注心肌:外 ,b復原、忮性靜脈與動脈腿溃瘍、壓迫 通的外傷是與由外科手術、碎深植、或一外科排液有關】 所引起的傷菩。與所引起的不足 ^ 愈谢i 'Ύ U.去 履准/王有關的典型疾病 動:::ΓμΓ硬化、靜脈機能不全、深血管检塞與 ===炎、糖尿病、風濕性關節炎、及 長時間而發生。 身植坐者或躺下一段 O:\65\65722-910515 DOC\ -18- 567078 A7 B7 五、發明説明(16 ) 本方法亦可提高運用在與疼痛、水腫、及/或發炎有關的 一身體傷害之一治療效果。在許多情況,先前非有效治療 的一病人可反應在一連串電磁場(EMFs)的相同治療上。如 此’本方法可提高身體對治療的反應,接著,可減緩伴隨 它的人體傷害與疼痛、水腫、及/或發炎。 裝 本方法是特別具實用性,其中一身體變成可抗拒用以治 療疾病或狀況的藥劑’而且電磁場(EMFs)的應用可自願同 意藥物或外科治療的能力,以改善身體的健康與活動力。 此治療的範例血管造形術、外科手術、隱靜脈切除術、皮 膚接枝、傷害終止、縫合、繃帶、抗高血壓治療、藥學成 i刀投丁、看護照顧與身體傷害清潔等。典型投予在受上述 傷害疼痛病人的藥物成份的範例是止痛劑、抗發炎藥劑、 抗生素、flavinoids、組織血漿素催化劑、阿斯匹林、 prostacyclin作用劑 ' prostan〇ids、venotonic藥品、纖維蛋白 訂567078 A7 B7 V. Description of the invention (12) In most cases, the lower limb arteriosclerosis is the first cause of arterial leg ulcers, and it will cause the arterial flow to significantly worsen and narrow and the peripheral circulating blood flow to gradually decrease. As the disease worsens, the arteriosclerotic damage usually expands. Insufficient nutritional support for peripheral microvascular circulation occurs when blood flow is completely diminished and nutritional capillary perfusion pressure is irregular. In addition, leukocyte adhesion, blood platelet agglutination, hemorheology, and increase in arteriolar microfibrinase can be seen. These help to further reduce the number of capillaries. Arterial changes are clinically described as temporary pain, nourishing skin changes, and ulcers. In addition, these injuries are often infected. II. 1 Treatment of chronic arterial leg ulcers The emergence of invasive treatments includes vascular angioplasty, vascular restoration and resection. Most medications focus on reduced pain and reduced infections. Currently, severe leg anemia is not recommended throughout Europe for any additional medical treatment of arterial leg ulcers. Iπ · 1 pressure ulcers (Wollo Qingwen, most pressure ulcers are common, and inactivity is complicated. In many cases 2, they will resist medical treatment. This resistance will be obvious with nutritional disorders, infection, and advanced age Increased. These ulcers usually increase the risk of patient death. ^ Acute care hospitals and nursing homes need to maintain a long nursing door. For example, in the case of spinal cord injury patients, this problem will have 7 _ 8 0 /. ^ Compression, friction, shearing force, and clear air will be involved in the onset of skin collapse, but the treatment will also be worsened by moderate infection. 111,1 (Lying posture ulcer) The most common treatment is to treat the patient Reset open # to avoid any special characteristics of the body: \ 65 \ 65722-91〇515d〇c \ 4 paper size _ A4 # .i () ^ 297 mm) 567078 A7 _____B7 V. Description of the invention (13) Excessive area oppression. In addition, the basic treatment procedure commonly used in these patients is general injury care, and treatment is to control the underlying disease. Patients also recommend moderate nutritional habits, and it is recommended to obtain ascorbic acid, zinc, and non-metallic supplements. IV. Chronic Injury In most cases of chronic injury, inadequate blood supply, edema, and tissue insufficiency, cell death and infection enhanced by aging and continued stress can be found in cells containing growth factors, hormones, etc., and in The immune neuroendocrine gland reduces peptide characteristics among the effects of communicating with reticular tissue. Due to the lack of a normal immune-mediated inflammatory response and / or recovery process, recovery is weakened. The treatments currently available are only partially effective, and long-term predictions are poor for these patients. The current state emphasizes the need for new methods to treat chronic injuries, such as the characteristics of cells and cytoplasm required for activated injury recovery, nerve fiber growth, angiogenesis, and angiogenesis. V. Myocardial infarction Arteriosclerosis is a general disease that causes, for example, arterial disease of the lower limbs (chronic arterial leg ulcers), myocardial infarction, and occlusive arterial disease with pulse. Etiological factors (arterial hypertension, high plasma cholesterol, smoking, stress, diabetes) are similar to these diseases. The majority of deaths in patients with myocardial infarction are caused by arrhythmia, infarct dilatation, and post-infarction changes. V. 1 Prevention of myocardial infarction. "Shi Zhixi focuses on removing or controlling the etiology factors. The mortality rate in the early stage of myocardial infarction can be reduced. After the use of blocking agents, hemolysis and blood tests, urethral catheters can be supplied to the vasculature. Or non-expansive vascular angioplasty, non-surgical hand O: \ 65 \ 65722-910515 D〇C \ 4 · 16- This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) for surgery and vascular tightening Transforming enzyme inhibitors, reached aspirin. For patients who are recoverable outside of low-perfusion myocardium and will not become coronary resupply vessels, vascular growth factors are still in clinical research VI. Fracture The three overlapping phases of fracture and fracture recovery have been described: a) an inflammatory phase similar to a skin injury inflammatory phase; b) a repair phase, in which osteoblasts diffuse and bone underwear tissue is the skin In the middle of sclerosis formation, and c) the transformation stage, in which fractured skin sclerosis and bones are transformed to voluntarily agree to the normal shape and strength. In the three stages of fracture, restoration of PBMCs and cytoplasm play an intermediate role. Objective The treatment system includes surgery, fixation, and local application of electromagnetic fields to bone formation. Νπ · Spinal muscle twilight in childhood and childhood Spinal muscular atrophy is one of the early onset and inherited progressive degenerative diseases of spinal motor muscle neurons. Although clinically similar to muscular dystrophy, in these patients, muscle atrophy is derived from nerve fiber degeneration. Some children can develop normally for several months before weakness becomes apparent. The drive, pelvis, and shoulder and waist muscle groups can be unevenly affected Disease will progress with stable alpha, and most patients have short life spans. Some can live for years and even work and maintain. At this stage, there is no help for the treatment of these diseases / sigma therapy a limited rehabilitation therapy and orthopedics. New ways to regenerate nerve fibers 疋 Therapeutic factors for neuropathy, Schwann cell treatment, and local application of current or electromagnetic fields to induce currents, although these treatments cannot be used to treat spinal muscle atrophy. O: \ 65 \ 65722-910515 DOCN 4 -17- 567078 V. Description of the invention (15 The types of diseases and conditions related to injury are for example Ministry Denervation: two groups: loss, burns, fractures, local anemia and traumatic injuries, k injuries and ulcers. Through a more specific example, the following diseases 4; can be restored by, for example, except hypoperfusion myocardium, etc .: No = Fluid injection, tissue gangrene, pain, edema, and infection; and T; Extending inactive fat spleen, secretive ^, so μ, bad betrayal, chronic injury and worsening scald == Shao and external chronic injury; by trauma, injury and surgery = ?: the situation 'e.g. Nerves and nerves are limited to recoverable in addition to low perfusion myocardium, such as ulcers caused by static = supine rectal cancer, high pressure cancer, moderate foot depression, spinal muscular atrophy, etc .; t !: Fate and cancer of the lower limbs are located in the body lion, ° Cancer of the lower limbs is individual or whole; Use this method: Buco :! Non-surgical. Usually non-trauma is in addition to hypoperfusion myocardial: In addition, b-recovery, iliac vein and arterial leg ulcers, compression trauma is related to injury caused by surgery, broken deep implants, or a surgical drainage]. Insufficient caused by ^ more thanks i 'Ύ U. Go to the standard / Wang's typical diseases related to :: ΓμΓ sclerosis, venous insufficiency, deep blood vessel plugging and === inflammation, diabetes, rheumatoid arthritis, And long time. Sitting seated or lying down O: \ 65 \ 65722-910515 DOC \ -18- 567078 A7 B7 V. Description of the invention (16) This method can also improve the application of a method related to pain, edema, and / or inflammation. One of the healing effects of physical injury. In many cases, a patient who was previously ineffectively treated can respond to the same treatment in a series of electromagnetic fields (EMFs). In this way, this method can improve the body's response to the treatment, and then, it can reduce the physical injury and pain, edema, and / or inflammation accompanying it. This method is particularly practical, in which a body becomes resistant to drugs used to treat a disease or condition, and the application of electromagnetic fields (EMFs) can voluntarily agree with the ability of drugs or surgical treatment to improve physical health and mobility. Examples of this treatment are angioplasty, surgery, saphenous vein resection, skin grafting, injury termination, sutures, bandages, antihypertensive treatment, pharmaceutical surgery, nursing care and body injury cleaning. Examples of pharmaceutical ingredients that are typically administered to patients suffering from the above mentioned pain are analgesics, anti-inflammatory agents, antibiotics, flavinoids, tissue plasmin catalysts, aspirin, prostacyclin agents, prostanoids, venotonic drugs, fibrin
線 溶解與溶解血栓藥劑、日常飲食等。這些藥劑亦可可根據 本發明連同或隨後投予電磁力。 本發明的較佳具體實施例現將參考圖式描述,而有助於 對本發明的了解。本治療可運用在如圖丨_2、8_9、1〇_n 、17-18、19-20、22-23、和25-20 所示的本發 明裝置。本裝置的各種不同具體實施例設計是衍生自只暴 $在本發明的時變磁場或連同靜磁場的類似問題之病人觀 察。圖1-9係描述連同靜磁場使用描時變磁場。圖8和9係描 述具有一足夠大内室的本發明之一放大具體實施例,以暴 露例如驅幹之一較大部份的人體。Thread dissolving and thrombolytic agents, daily diet, etc. These medicaments may also be administered with or subsequently to electromagnetic force according to the present invention. The preferred embodiments of the present invention will now be described with reference to the drawings to facilitate the understanding of the present invention. The treatment can be applied to the device of the present invention as shown in Figs. _2, 8_9, 10_n, 17-18, 19-20, 22-23, and 25-20. Various specific embodiments of the device are designed to be derived from patient observations of similar problems in the time-varying magnetic field of the present invention or in conjunction with static magnetic fields. Figures 1-9 describe the use of a time-varying magnetic field in conjunction with a static magnetic field. Figures 8 and 9 depict an enlarged embodiment of the invention having a sufficiently large interior chamber to expose, for example, a large portion of the human body.
567078 A7 B7567078 A7 B7
在成功使用多次的裝置之特別較佳具體實施例中,永久 磁鐵可去除,但是時變電磁場要維持。參考圖1〇到16。另 一具體實施例可提供類似一先前描述的裝置,但是具有一 足夠大内室,以暴露一部份的人體,例如將在室内部的從 大動脈的上限到肝臟與脾臟的下限到磁場。參考圖17和18 。如此,相同特性的時變磁場可運用在病人的大血液與淋 巴管:大動脈、vana腔靜脈與胸管、及大的血液與淋巴槽 :心、肺、肝臟、脾臟、與外脊椎神經中樞。此治療要同 時將大量週邊的血液單核白血球細胞暴露在電磁場,並且 減少治療時間。裝置的這些具體實施例的設計可在暴露磁 場期間提供病人的一舒服位置。 在仍然是本發明裝置的另一具體實施例中,時變磁場的 特性是與上述裝置相同,但是可由例如兩平行線圈產生, 亦即Hemholtz線圈。該等線圈可在他們之間的中心產生均 質的電磁場。此具體實施例可將躺在床上的人體部份暴露 在時間變用磁場。參考圖1 9 - 2 2。 然而,另一具體實施例可提供上述裝置的一略微變化, 但是類似的設備是倒置,而且固定在非磁材料製成的一窄 床旁邊。由線圈產生的磁通量流向會垂直於人體的軸線。 控制可在床邊容易設置,如圖2 3所示。 本裝置的另一具體貫施例是在一鞍部配置線圈,所以磁 場可垂直肢體行進。此設備是為獸醫應用而建構,且已成 功使用來治療一馬的發炎接合處與皮膚傷害。然而,它亦 可使用在人類。參考圖2 5到2 8。 O:\65\65722-910515 D〇C\ 4 本紙張尺度適用中國國家標準(CNS) A4規格(210 χ 297公釐)In a particularly preferred embodiment of the device that has been used multiple times successfully, the permanent magnet is removable, but the time-varying electromagnetic field is maintained. Refer to Figures 10 to 16. Another embodiment may provide a device similar to that previously described, but with a large enough internal chamber to expose a portion of the human body, such as from the upper limit of the aorta to the lower limit of the liver and spleen to the magnetic field inside the room. Refer to Figures 17 and 18. In this way, time-varying magnetic fields with the same characteristics can be applied to patients' large blood and lymphatic vessels: the aorta, vana vena cava and chest tube, and large blood and lymphatic grooves: heart, lung, liver, spleen, and external spinal nerve center. This treatment involves exposing a large number of peripheral blood mononuclear white blood cells to the electromagnetic field and reducing the treatment time. These specific embodiments of the device are designed to provide a comfortable position for the patient during the magnetic field exposure. In still another embodiment of the device of the present invention, the characteristics of the time-varying magnetic field are the same as those of the above device, but can be generated by, for example, two parallel coils, that is, Hemholtz coils. These coils produce a homogeneous electromagnetic field in the center between them. This embodiment can expose a human body part lying on a bed to a time-varying magnetic field. Refer to Figure 19-22. However, another specific embodiment may provide a slight variation of the above device, but similar equipment is inverted and fixed next to a narrow bed made of non-magnetic material. The direction of the magnetic flux generated by the coil will be perpendicular to the axis of the human body. The controls can be easily set by the bed, as shown in Figure 2-3. Another specific embodiment of the device is a coil disposed in a saddle, so that the magnetic field can travel perpendicular to the limb. This device is built for veterinary applications and has been successfully used to treat a horse's irritated joints and skin injuries. However, it can also be used in humans. Refer to Figures 25 to 28. O: \ 65 \ 65722-910515 D〇C \ 4 This paper size is applicable to China National Standard (CNS) A4 specification (210 x 297 mm)
裝 訂Binding
五 、發明説明( 18 在仍然是本發明的另一且触奋、* 能以兩不同方式產生」方n本發明的電磁場 办m馇"產其可在本發明的相同或類似頻率上藉由 電與磁能量(亦即··著重在任何 (傳=二天線)。另一方法係藉由調變高強度與頻率 太私日电磁场,例如由泰斯拉線圈所產生的電磁場:與 採用的頻率相同或類似。在後者情況中,行經空 t磁场可到達躺或坐著的—病人,而不會到達裝置。 μ即參考圖i和2,本發明裝置的—具體實施例可以是一 矩形或万塊盒101的—般形狀,其可以是木質、塑膠、或其 他非磁材料製成’以避免干擾病人身體部位的一電磁場應 用。裝置的前面或面板103通常具有一圓形開口 104,其擴 充如同在益101中的一拉長環狀通道1〇5。通道1〇5通常可在 盈101内水平擴充,而且當不使用時,它可關閉,而且在背 牆或面板111上具有一末端109。理想在面板1〇3上安裝的是 一計時器113及一控制機制115,該等兩係連接至一電子面 板1Π,用以改變及控制磁場的強度與持續時間。 如圖6所示,在通道1 〇5的每個内縱向端上的配置是一螺 線圈119,用以供應一時變磁場❹此外,圖6係顯示永久磁 鐵121,用以供應靜磁場。請即參考圖7,一電流可從一交 流電源(未在圖顯示)經由電源線路123、125提供,並且送入 一變壓器127及一橋式穩壓器129至磁線圈119。將電流提供 給螺線圈的方法與細節在技藝中是眾所周知,而且在本發 明本質不是重要的。 -21 - O:\65\65722-910515.DOC\ 4 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐) 567078 A7V. Description of the invention (18 is still another and exciting of the present invention, and * can be generated in two different ways. "The electromagnetic field of the present invention can be borrowed at the same or similar frequency of the present invention. By electric and magnetic energy (that is, focusing on any (transmission = two antennas). Another method is to adjust the electromagnetic field of high intensity and frequency too private, such as the electromagnetic field generated by a Tesla coil: and using The frequency is the same or similar. In the latter case, the magnetic field passing through the empty t can reach the lying or sitting patient, but not the device. Μ That is, referring to FIGS. The general shape of a rectangular or one-piece box 101, which can be made of wood, plastic, or other non-magnetic materials' to avoid interference with an electromagnetic field application of the patient's body part. The front or panel 103 of the device usually has a circular opening 104 Its expansion is like an elongated circular channel 105 in Yi 101. Channel 105 can usually be expanded horizontally in Ying 101, and when not in use, it can be closed, and on the back wall or panel 111 Has a terminal 109. Ideal Installed on the panel 103 is a timer 113 and a control mechanism 115, which are connected to an electronic panel 1Π to change and control the strength and duration of the magnetic field. As shown in Figure 6, in the channel The configuration on each inner longitudinal end of the 105 is a spiral coil 119 for supplying a time-varying magnetic field. In addition, FIG. 6 shows a permanent magnet 121 for supplying a static magnetic field. Please refer to FIG. 7 for a current. It is supplied from an AC power source (not shown in the figure) via power lines 123, 125, and is fed into a transformer 127 and a bridge regulator 129 to the magnetic coil 119. The method and details of supplying current to the spiral coil are in the art As we all know, and it is not important in the essence of the present invention. -21-O: \ 65 \ 65722-910515.DOC \ 4 This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) 567078 A7
^即參考圖8和9 ’另一具體實施例可提供類似在先前段 洛中所描述的-裝置。此具體實施例是在圖⑴所示的且 ^實施例的一放大版本。此第二具體實施例允許將部份或 整個身體暴露在如圖8和9所示的電磁力。在此設計中,主 血管(大動脈、腔靜脈血管)胸管、外脊椎淋巴節點、與主 血槽(肝臟、脾臟、肺、與心)可同時暴露在時變磁場與靜 磁場(未在圖顯示)的組合,以減少病人的暴露時間。 此裝置具有-圓形外殼130 ’其包含線圈119與強永久磁鐵 121。該圓形外殼13〇具有一内室132,其足夠大到可將一病 人134的身體部位暴露在磁場。該外殼13〇可固定在由非磁 材料製成的一窄床136。如先前具體實施例,連接至一電子 面板的計時器113與控制機制115可位在床邊。理想上,該 外殼是例如木質或塑膠的一非磁材料製成。 在圖10和11所示的另一具體實施例中,圖具體實施 例的相同裝置可使用,而無需永久磁鐵121。如圖13所示, 此具體實施例亦包括一線圈支撐250 ,用以支撐線圈丨19及 一管壁252。 在如圖14至16所示的另一具體實施例中,其是在圖^〇至 1 3所示的先前具體實施例之一簡化肢本。例如一磁線圈ι57 的螺線圈是安裝在一圓柱形外殼15 8内。圓柱形外殼15 8係 包括從其形成的一拉長環狀通道15 9。磁線圈15 7可配置在 圓柱形外殼158内,而且是在環狀通道159的附近。外殼與 環狀通道的大小要符合例如一病人的前臂160或上臂162之 一病人肢體,以允許病人暴露在電磁力時更可活動。 -22- O:\65\65722-910515 D〇C\ 4 本纸張尺度適用中國國家標準(CNS) A4規格(210X297公釐) 567078 A7 ----- ----B7 五、發明説^~~ --- 因此,此設計允許舒服及活動肢體暴露在本發明的εν% 。理想上,圓柱形外殼是由一輕的非磁材料製成。此非磁 材料係包括塑膠或木質。而且,變壓器m與橋式穩壓器 129(在圖7_示)連同連接至一電源的一對接觸μ].電源是 包含在—小轉接器盒15〇内’以輕易獲得來自一交流電源( 未在圖顯示)的電流。包含的具接觸部位的轉接器盒15〇、 變壓裔、與橋式穩壓器係藉由可將電流提供給線圈157的兩 長電纜154而連接至線圈157。 凊即參考圖1 7和1 8,另一具體實施例可提供類似在圖i 〇 至1 3所示具體實施例的一裝置。此具體實施例是在圖丨〇至 1 3所tf具體實施例的一放大版本。此具體實施例允許部份 或整個身體暴露在如圖1 7和1 8所示的電磁力。在此設計中 ,主血管(大動脈與腔靜脈血管)胸管、外脊椎淋巴節點、 與主血槽(肝臟、脾臟、肺、與心)可同時暴露在電磁力(未 在圖顯示),以減少病人的暴露時間。此裝置具有包含線圈 119之一圓形外殼260,並且包括足夠將一位病人204身體部 位暴露在磁場的一内室262。外殼260可固定在非磁材料製 成的一窄床245。連接至一電子面板的計時器i 13與控制機 制115可位在床邊。理想上,該外殼是例如木質或塑膠之一 非磁材料製成。 一磁場亦能以在圖1 9和2 0所述的另一具體實施例提供。 此裝置可以是在U形外殼200的一般形狀。請即參考圖2 2, 一病人204的部份身體根據本發明可暴露在裝置外殼2〇〇的 側壁208之間的一同質電磁場。該裝置可以是木質、塑膠、 -23- O:\65\65722-910515.DOC\ 本紙張尺度適用中國國家標準(CNS) A4規格(210X297公釐) 567078 A7 ^一 __— Β7 五、發明説明(Μ ) 或其他非磁材料製成,以避免干擾對一病人身體部位的電 磁場應用。請即重新參考圖19,在面板212上所安裝的是一 計時器214夂一控制機制216,該等兩係連接至如圖20所示 的一電子面板218,用以改變及控制電磁場的強度與持續時 間。 如圖2 0所示,在側壁2〇8的每個内部上所配置的是一線圈 224 ’用以供應時變的磁場。該等側壁可當作支撐使用,以 維持在Helmholtz配置的線圈。圖21係顯示由相對Hemholtz 線圈224所產生的電磁通量之一圖式。請即參考圖2 4 , 一電 流是藉由電源線路230、232而從一交流電源(未在圖顯示)提 供,並且送入一變壓器234及一橋式穩壓器236。若要減少 電流在線圈造成的熱量,一電容器23 8與電阻240可用來減 少磁線圈的有效電流224。一風扇可用來冷卻電阻。用以將 電流提供給線圈的方法與細節在技藝中是眾所周知,而且 在本發明本質不是重要的。 此具體貫施例的一略微變化是在圖2 3顯示。在此具體實 施例是使用類似的設備,但是外殼200是倒置,並且固定在 以非磁材料製成的窄床245旁邊。由線圈所產生的磁通量現 在是垂直於身體204的軸線。計時器與控制機制214和216可 容易放在床邊。 本發明裝置的另一具體實施例是在圖25和26描述。裝置 可以是一鞍狀物280。請即參考圖2 8,鞍狀物係根據本發明 而放置在一肢體或一身體部位282,以便將一病人暴露在同 質電磁場。該裝置可以是木質、塑膠、或其他非磁材料製 O:\65\65722-910515.DOC\ 4 - 24 - 本纸張尺度適用中國國家標準(CNS) A4规格(210X297公釐) 567078 A7 _______ B7 五、發明説明(22 ) 成’以避免干擾一病人身體部位的電磁場應用。如圖25和 2 6所示’該鞍狀物是經由電纜288而連接至控制單元29〇, 該控制單元係包含一計時器292及一控制機制294,該等兩 係連接至電子面板(未在圖顯示).,用以改變及控制電磁場 的強度與持續時間。 如圖2 6所示,在鞍狀物壁内部上所配置的是線圈298,用 以提供時變磁場。請即參考圖24 ,於先前具體實施例所使 用的電路相同,圖19至23可用來將電流傳送給在圖25至28 所述目則具體貫施例的線圈298。一電流可從一交流電源( 未在圖顯示)經由電源線路23〇、232提供,並且送入變壓器 234與橋式穩壓器236。若要避免電流使線圈加熱,一電容 器238與電阻240可用來減少磁線圈298的有效電流,而且風 扇可用來冷卻電阻。用以將電流提供給線圈的方式與細節 在技蟄中是眾所周知,而且在本發明本質不是重要的。 本發明的電磁場產生有兩額外方法。一是透過調變一連 、貝的27· 12 Μ赫炫,其可在本發明的相同頻率上藉由空間(傳 迻波)傳送私磁波(亦即著重在任何方向的本發明電磁場之 天、’泉)而且另疋透過凋變本發明的相同頻率,高強度 的電磁場與解可由TesU線圈(傳送波)產生。此最後設計 的電磁場可行經空間,如此躺在床或坐在接近來源之一病 人可治療,而不用看著裝置。 為了要根據本發明的方法㈣受皮膚傷害或内傷疼痛之 一病人,病人的肢體(例如一手或—部份手臂)可插入開口 104 ’且邵份可藉由通道105延伸。電源然後會導通,以便 O:\65\65722-910515 DOC\ 4 -25 -^ That is, referring to Figs. 8 and 9 ', another embodiment may provide a device similar to that described in the previous paragraph. This specific embodiment is an enlarged version of the embodiment shown in FIG. This second specific embodiment allows exposing part or the entire body to electromagnetic forces as shown in Figs. In this design, the main vessels (aorta, vena cava vessels) of the chest tube, external spinal lymph nodes, and the main blood tank (liver, spleen, lung, and heart) can be exposed to both time-varying magnetic fields and static magnetic fields (not shown in the figure). (Shown) to reduce patient exposure time. This device has a circular housing 130 'which contains a coil 119 and a strong permanent magnet 121. The circular housing 130 has an inner chamber 132 that is large enough to expose a body part of a patient 134 to a magnetic field. The housing 130 can be fixed to a narrow bed 136 made of a non-magnetic material. As in the previous embodiment, the timer 113 and the control mechanism 115 connected to an electronic panel can be located beside the bed. Ideally, the housing is made of a non-magnetic material such as wood or plastic. In another embodiment shown in Figs. 10 and 11, the same device of the embodiment shown in Fig. 11 can be used without a permanent magnet 121. As shown in FIG. 13, this specific embodiment also includes a coil support 250 for supporting the coil 19 and a tube wall 252. In another embodiment shown in FIGS. 14 to 16, it is a simplified version of one of the previous embodiments shown in FIGS. 10 to 13. For example, a solenoid of a magnetic coil ι57 is installed in a cylindrical housing 15 8. The cylindrical housing 15 8 series includes an elongated annular channel 15 9 formed therefrom. The magnetic coil 157 may be arranged in the cylindrical housing 158 and near the annular passage 159. The size of the housing and the annular channel should conform to a patient's limb, such as a patient's forearm 160 or upper arm 162, to allow the patient to be more mobile when exposed to electromagnetic forces. -22- O: \ 65 \ 65722-910515 D〇C \ 4 This paper size is applicable to China National Standard (CNS) A4 (210X297 mm) 567078 A7 ----- ---- B7 V. Invention ^ ~~ --- Therefore, this design allows comfortable and active limbs to be exposed to εν% of the present invention. Ideally, the cylindrical housing is made of a light non-magnetic material. This non-magnetic material includes plastic or wood. Moreover, the transformer m and the bridge regulator 129 (shown in FIG. 7_) together with a pair of contacts connected to a power supply μ]. The power supply is included in a small adapter box 15 ′ to easily obtain an AC from an AC The current of the power supply (not shown). The included adapter box 15 with a contact portion, a transformer, and a bridge regulator are connected to the coil 157 by two long cables 154 which can supply current to the coil 157. That is, referring to FIGS. 17 and 18, another specific embodiment may provide a device similar to the specific embodiments shown in FIGS. 10 to 13. This specific embodiment is an enlarged version of the specific embodiment tf shown in FIGS. This embodiment allows part or the entire body to be exposed to electromagnetic forces as shown in Figs. In this design, the main vessels (aorta and vena cava vessels) of the chest tube, external spinal lymph nodes, and the main blood tank (liver, spleen, lung, and heart) can be simultaneously exposed to electromagnetic forces (not shown in the figure) to Reduce patient exposure time. This device has a circular housing 260 containing a coil 119 and includes an internal chamber 262 sufficient to expose a patient 204 body part to a magnetic field. The housing 260 may be fixed to a narrow bed 245 made of a non-magnetic material. A timer i 13 and a control mechanism 115 connected to an electronic panel can be positioned beside the bed. Ideally, the housing is made of a non-magnetic material such as wood or plastic. A magnetic field can also be provided in another specific embodiment described in FIGS. 19 and 20. This device may be in the general shape of a U-shaped housing 200. Referring now to FIG. 22, a part of the body of a patient 204 may be exposed to a homogeneous electromagnetic field between the side walls 208 of the device housing 200 according to the present invention. The device can be wood, plastic, -23- O: \ 65 \ 65722-910515.DOC \ This paper size is applicable to China National Standard (CNS) A4 specification (210X297 mm) 567078 A7 ^ __ — Β7 V. Invention (M) or other non-magnetic material to avoid interference with the application of electromagnetic fields to a patient's body part. Please refer to FIG. 19 again. What is installed on the panel 212 is a timer 214 and a control mechanism 216. These two systems are connected to an electronic panel 218 as shown in FIG. 20 to change and control the intensity of the electromagnetic field. With duration. As shown in FIG. 20, disposed on each inside of the side wall 208 is a coil 224 'for supplying a time-varying magnetic field. These side walls can be used as support to maintain the coils in Helmholtz configuration. FIG. 21 is a diagram showing an electromagnetic flux generated by the opposite Hemholtz coil 224. Please refer to FIG. 24. A current is supplied from an AC power source (not shown in the figure) through the power lines 230, 232, and is fed into a transformer 234 and a bridge regulator 236. To reduce the heat generated by the current in the coil, a capacitor 23 8 and a resistor 240 can be used to reduce the effective current 224 of the magnetic coil. A fan can be used to cool the resistor. The methods and details for supplying current to the coil are well known in the art and are not essential to the nature of the invention. A slight variation of this specific embodiment is shown in FIG. The specific embodiment here uses similar equipment, but the housing 200 is upside down and fixed next to a narrow bed 245 made of a non-magnetic material. The magnetic flux generated by the coil is now perpendicular to the axis of the body 204. The timer and control mechanisms 214 and 216 can be easily placed by the bed. Another specific embodiment of the device of the present invention is described in Figs. The device may be a saddle 280. Referring now to FIG. 28, a saddle is placed on a limb or a body part 282 according to the present invention to expose a patient to a homogeneous electromagnetic field. The device can be made of wood, plastic, or other non-magnetic materials. O: \ 65 \ 65722-910515.DOC \ 4-24-This paper size applies to China National Standard (CNS) A4 (210X297 mm) 567078 A7 _______ B7 V. Description of the invention (22) It is used to avoid interference with the electromagnetic field of a patient's body part. As shown in Figures 25 and 26, the saddle is connected to the control unit 29 through a cable 288. The control unit includes a timer 292 and a control mechanism 294, which are connected to an electronic panel (not (Shown in the figure). It is used to change and control the intensity and duration of the electromagnetic field. As shown in Fig. 26, a coil 298 is arranged inside the saddle wall to provide a time-varying magnetic field. Please refer to FIG. 24. The circuit used in the previous embodiment is the same. FIGS. 19 to 23 can be used to transmit current to the coil 298 in the embodiment described in FIGS. 25 to 28. A current can be supplied from an AC power source (not shown in the figure) via the power lines 23, 232, and fed into the transformer 234 and the bridge regulator 236. To prevent current from heating the coil, a capacitor 238 and resistor 240 can be used to reduce the effective current of the magnetic coil 298, and a fan can be used to cool the resistor. The means and details for supplying current to the coil are well known in the art and are not essential to the nature of the invention. There are two additional methods of generating the electromagnetic field of the present invention. The first is through modulation of a continuous line of 27.12 MHz, which can transmit private magnetic waves (that is, focusing on the electromagnetic field of the present invention in any direction) at the same frequency of the present invention through space (transfer wave). Moreover, by altering the same frequency of the present invention, a high-intensity electromagnetic field and solution can be generated by a TesU coil (transmission wave). This last-designed electromagnetic field can pass through space so that a patient lying in bed or sitting close to one of the sources can be treated without looking at the device. For a patient suffering from skin or internal injury pain according to the method of the present invention, a patient's limb (e.g., one hand or-part of the arm) can be inserted into the opening 104 'and the portion can be extended through the channel 105. The power will then turn on so that O: \ 65 \ 65722-910515 DOC \ 4 -25-
567078 A7 B7 五、發明説明(23 ) " 將一電流提供給螺線圈119。由在空間1〇7内的磁場所產生 的磁通線是在圖3顯示,而且可看出包含可變與靜磁通量線 二可發現到當電磁場是在超過i赫茲到小於大约3〇〇赫茲非 常2頻率上應用時,治療會最有效。時變磁場的頻譜内容 較咼於大約120赫茲及其諧波附近。可參考例如圖5 ^這些 頻f具有大約0.3至大約〇·8 mT均方根值(rms)強度的一靜 磁場元件,而且這些電磁力可單獨使用或與大約4 〇至大約 80 mT(大約4〇〇至大約8〇〇高斯)的一同質靜磁場結合使用。 因此,有兩靜磁場:一的產生是接合時變磁場,而且理想 具有數微磁通量密度到最大約〇 3至大約〇 8 mT (rms)之一 低磁通量,並且提供大約4〇至大約8〇爪丁的一磁通量密度 <水久磁鐵,其等於大約4〇〇至大約8〇〇高斯。在電路到磁 線圈所供應瞬間電流之間的關係如在圖4所示一連串波形的 時間函數。如先前所示,具數赫茲(超過丨)到小於約3〇〇赫 茲頻率的時變磁場應用,及具有單獨使用的大約〇.3至大約 0 ·8 mT強度的靜磁場元件、或具大約4 〇到㈤丁或大約4〇〇 至大約800高斯之一同質靜磁場同步應用係構成本發明方法 的一必要(重要)特徵。 病人觀察到的本方法與裝置之傷害復原效果可透過只供 應在此本專利所述的時變電磁場、或結合靜電磁場而獲得 。然而,通常分開的每個元件及他們組合可在週邊血單核 白血球、’’田胞(PBMCs)擴散上證明不同程度的效果。此可在 圖29伴隨此病人清楚看出,其顯示當運用從正常身體 (loo%細胞擴散控制是ΡΒΜ(::Μέ用細胞分裂刺激擴散,而無 O:\65\65722-910515.DOC\ 4567078 A7 B7 V. Description of the invention (23) " Supply a current to the spiral coil 119. The magnetic flux lines generated by the magnetic field in space 107 are shown in Figure 3, and it can be seen that the variable and static magnetic flux lines are included. It can be found that when the electromagnetic field is more than i Hertz to less than about 300 Hertz Treatment is most effective when applied at very 2 frequencies. The spectral content of a time-varying magnetic field is smaller than about 120 Hz and its harmonics. Reference may be made to, for example, FIG. 5 ^ These frequencies f have a static magnetic field element having a strength of about 0.3 to about 0.8 mT rms, and these electromagnetic forces can be used alone or in combination with about 40 to about 80 mT (about 400 to about 800 Gauss) in combination with a homostatic magnetic field. Therefore, there are two static magnetic fields: the generation of one is a time-varying magnetic field of the joint, and ideally has a low magnetic flux density of several micro-magnetic flux densities to a maximum of about 0.3 to about 0.8 mT (rms), and provides about 40 to about 80. A magnetic flux density of the claw is < Hydromagnet, which is equal to about 400 to about 800 Gauss. The relationship between the instantaneous current supplied from the circuit to the magnetic coil is as a function of time in a series of waveforms as shown in FIG. As shown previously, time-varying magnetic field applications with frequencies from a few hertz (over 丨) to less than about 300 Hz, and static magnetic field elements with a strength of about 0.3 to about 0.8 mT used alone, or A synchronous application of a homogeneous static magnetic field of one to 40 to 300 or about 400 to about 800 Gauss constitutes an essential (important) feature of the method of the present invention. The damage recovery effect of the method and device observed by the patient can be obtained by supplying only the time-varying electromagnetic field described in this patent, or combining the electrostatic magnetic field. However, each element and their combination that are usually separated can demonstrate varying degrees of effect on the proliferation of peripheral blood mononuclear leukocytes, ' field cells (PBMCs). This can be clearly seen with this patient in Figure 29, which shows that when applied from the normal body (loo% cell proliferation control is PBM (:: Μι), the proliferation is stimulated by cell division without O: \ 65 \ 65722-910515.DOC \ 4
567078 A7 B7 五、發明説明(24 ) —— 需本發明的任何(EMFs))所獲得的PBMCs時,由不同類型的 磁場所證明細胞擴散的不同程度效果。靜態與時變場^ 一 結合應用可產生PBMCs擴散(p<〇.〇〇i Student „τ,,測試)的 11.1%增加,一時變磁場的應用可單獨產生PBMCs擴散 (Ρ<0·001 Student ’·Τ·’測試)的67%減少,而且一靜磁場的應 用在PBMCs擴散上沒有明顯的效果。 對於來自治療的最大利益而言,磁場理想可在大約數分 鐘到大約8小時的病人肢體。較佳的暴露時間可計算,所以 一血液量同等於病人整個血液量是至少一次暴露在磁場。 該暴露頻率變化可從每日最大約3〇分鐘到7小時、到最小一 週大約3 0分鐘,其決定在觀察的傷害復原與所觀察的傷害 復原。 口 私磁力的應用根據本發明可運用在隔離週邊的血單核白 血球細胞(PBMCs),以調變他們的擴散模式,他們的系統 效果與外部時變磁場或結合靜態可變磁場的應用可治療病 人的慢性皮膚潰瘍、慢性傷害、除了低灌注心肌之外的可 復原、骨折、與部份去神經支配是在下列範例描述。 下列範例係描述本發明方法的效力。然而,這些範例只 描述本發明,而未構成對本發明範圍的限制。 範例 效果 下列貫驗係顯示根據本發明在週邊血單核白血球細胞 ⑽MCs)上所運用的電磁場(EMFs)效果。 氣例1 •在PBMC擴散上的不同電磁場效果 O:\65\65722-910515DOC\ 4 ______ -27- ^張尺細中— 裝· .......... 線 567078567078 A7 B7 V. Description of the Invention (24) ——When PBMCs obtained by any (EMFs) of the present invention are required, the effects of different degrees of cell proliferation are demonstrated by different types of magnetic fields. Static and time-varying fields ^ A combination of applications can generate an increase of 11.1% in PBMCs diffusion (p < 〇.〇i Student „τ ,, test), and applications of a time-varying magnetic field can generate PBMCs diffusion alone (P < 0 · 001 Student 67% reduction in the '· Τ ·' test), and the application of a static magnetic field has no significant effect on the diffusion of PBMCs. For the greatest benefit from treatment, the magnetic field ideally can be in the limbs of a patient in about minutes to about 8 hours The optimal exposure time can be calculated, so a blood volume equal to the entire blood volume of the patient is exposed to the magnetic field at least once. The exposure frequency can vary from a maximum of about 30 minutes to 7 hours per day to a minimum of about 30 minutes a week. It determines the restoration of the observed damage and the restoration of the observed damage. The application of the private magnetic force according to the present invention can be used to isolate peripheral blood mononuclear white blood cells (PBMCs) to modulate their diffusion mode and their systemic effect Application with external time-varying magnetic field or combined with static variable magnetic field can treat patients with chronic skin ulcers, chronic injuries, resilience other than hypoperfusion myocardium, Fractures and partial denervation are described in the following examples. The following examples describe the effectiveness of the method of the present invention. However, these examples only describe the present invention and do not constitute a limitation on the scope of the present invention. Example effects The electromagnetic field (EMFs) effect used by the present invention on peripheral blood mononuclear white blood cell cells (MCs). Example 1 • Different electromagnetic field effects on PBMC diffusion O: \ 65 \ 65722-910515DOC \ 4 ______ -27- ^ Zhang Ruler Thin — Outfitting ............... Line 567078
週邊的血單核白血球細胞(PBMCs)可透過靜脈破壞及在最 後梯度上分餾獲得。包含PBMCs的部份要洗3次,而且在磷 酸鹽緩和食鹽水中重新混合到每公撮5 χ 1〇6cells。每公撮5 X 106 cells的PBMCs能整除0.2 ml能整除加上細胞分裂的“ m/ml可放置在小塑膠管。4個部份會形成(每個部份有3個 管)。第一部份會受遮蔽不受磁場影響。第2部份可根據本 發明而暴露在時變電磁場靜磁場組合,第3部份可根據本發 明只暴露在到時變電磁場,及第4部份可根據本發明只暴露 在靜磁場。這些4個部份皆會準備,而不必細胞分裂(控制) ,而且在相同實驗狀況下放置。 所有管子是在一二氧化碳濕潤器細菌培養器(F〇rma Scientific Mod 3325雙-Chamber C02-水套細菌培養器)係以 37QC培養。在58小時的一潛伏期間之後,311_胸腺嘧啶(5-6μ Ci/mM最後濃度)會加到所有的管子,並且培養一額外 1 4小時。所有管子可在7 2個小時獲得結果,並且使用一細 胞收獲機(Skraton、Tranby、Norway)藉由玻璃纖維濾紙洗 條。H-胸腺χ»密咬結合可透過使用一液體閃爍器計數器 (Beckmann Mod LS 6000 SE)決定。每分鐘的計數平均數目 可透過在每個取樣中的3倍獲得。細胞生存能力始終大於 9 0 % ’其係決定在trypan藍色排除的基礎上。圖2 7伴隨此病 人係顯示在從正常身體獲得PBMCs上的磁場效果。 結合的靜與時變電磁場可在PBMCs擴散(P< 0.001 student ’’τ ’’測試)產生一 1 1 %增加。時變電磁場在細胞擴散 (Ρ<0·001 Student ΠΊΓ測試)只產生大約67%減少。靜磁場 O:\65\65722-910515 DOC\ 4 本紙張尺度適用中國國家標準(CNS) A4規格(210X297公釐) -28-Peripheral blood mononuclear white blood cells (PBMCs) can be obtained by venous destruction and fractional distillation on the final gradient. The portion containing PBMCs was washed three times and remixed to 5 x 106 cells per milliliter in phosphate buffered saline. Each pin of 5 X 106 cells of PBMCs can be divided by 0.2 ml. The "m / ml" which can be divided and the cell division can be placed in small plastic tubes. 4 parts will be formed (each part has 3 tubes). First Part will be shielded from the magnetic field. Part 2 can be exposed to the time-varying electromagnetic field static magnetic field combination according to the present invention, part 3 can be exposed to the time-varying electromagnetic field only according to the present invention, and part 4 can be According to the present invention, it is only exposed to the static magnetic field. These 4 parts are prepared without cell division (control) and placed under the same experimental conditions. All tubes are in a carbon dioxide humidifier bacterial incubator (Foma Scientific) Mod 3325 Double-Chamber C02-water jacketed bacterial incubator) was cultured at 37QC. After a latency period of 58 hours, 311_thymine (5-6 μ Ci / mM final concentration) will be added to all tubes and cultured An additional 14 hours. All tubes can obtain results in 72 hours, and the strips are washed with glass fiber filter paper using a cell harvester (Skraton, Tranby, Norway). H-thymus χ »Bite binding can be used by using a Liquid scintillator count (Beckmann Mod LS 6000 SE). The average number of counts per minute can be obtained by 3 times in each sample. Cell viability is always greater than 90% 'It is determined on the basis of trypan blue exclusion. Figure 2 7 Accompanying this patient showed the effect of magnetic field on PBMCs obtained from normal body. The combined static and time-varying electromagnetic field can produce a 11% increase in PBMCs diffusion (P < 0.001 student `` τ '' test). Time-varying electromagnetic field The cell spreading (P < 0 · 001 Student ΠΊΓ test) produced only about 67% reduction. Static magnetic field O: \ 65 \ 65722-910515 DOC \ 4 This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) -28-
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在PBMCs擴散上沒有效果。因此,在實驗在隔離的p]gMCs 上證明一磁場效果,其是不同於每個類型的磁場或它的組 合0 兹果輿安+ q穿No effect on PBMCs diffusion. Therefore, in experiments, a magnetic field effect is demonstrated on isolated p] gMCs, which is different from each type of magnetic field or its combination.
裝 ίεΑΙ:在身體傷害上的電磁力效果(安全與容許研究) 既然電磁場會橫過生物組織,所以他們可在循環的 PBMCs上產生效果。單獨或與靜磁場組合的本發明之時變 私磁%效果可甚至在將位在傷害位置的一身體部位暴露在 本發明電磁力只大約30分鐘到丨小時之後,可在慢性皮膚傷 害上觀察到。在這段時間,普遍可看到一傷害變乾燥,並 且減少它的直徑。 訂Equipment ίεΑΙ: Electromagnetic effects on physical injury (safety and tolerance studies) Since electromagnetic fields cross biological tissues, they can produce effects on circulating PBMCs. The time-varying private magnetic% effect of the present invention, alone or in combination with a static magnetic field, can be observed on chronic skin injuries even after exposing a body part at the injury location to the electromagnetic force of the present invention for only about 30 minutes to 丨 hours Here. During this time, it is common to see a wound dry out and reduce its diameter. Order
線 在此專利中描述的裝置所產生的磁場安全性如世界健康 組織(WHO)所建議的下面暴露限制。然而,事實是這是一 率先的程序,下列研究的執行可說明本發明磁場的外部應 用對人體的安全性。在提出一自動許可狀以加入磁場協定 之後,每位病人會在暴露磁場之前有一完整的臨床病歷、 身體檢查、血化學、細胞血液計數、與尿液分析。在暴露 電磁場之前、期間、與之後,一心電圖可被執行,而且血 壓可被測量。三群的志願者便可形成。第一群是每日3 〇分 鐘暴露在電磁力(EMFs) ’第二群是一週兩次3〇分鐘,而且 第三群是一週一次30分鐘。這些3個允許一年不會出現負面 的副作用。 在最後5年,超過100位病人已根據本發明方法而以一週工 到7次,一天1到7小時暴露在外部磁場。在這些治療的過程 O:\65\65722-910515 DOC\ 4 -29-The magnetic field generated by the device described in this patent is as safe as the following exposure limits recommended by the World Health Organization (WHO). However, the fact is that this is a pioneering procedure, and the execution of the following study illustrates the safety of the external application of the magnetic field of the present invention to the human body. After submitting an automatic permit to join the magnetic field agreement, each patient will have a complete clinical history, physical examination, blood chemistry, cell blood count, and urine analysis before the magnetic field is exposed. An ECG can be performed before, during, and after exposure to the electromagnetic field, and blood pressure can be measured. Three groups of volunteers can be formed. The first group is exposed to electromagnetic forces (EMFs) at 30 minutes daily. The second group is 30 minutes twice a week, and the third group is 30 minutes once a week. These three allow one year without negative side effects. In the last 5 years, more than 100 patients have been exposed to an external magnetic field 1 to 7 hours a day in accordance with the method of the present invention, working 7 times a week. During these treatments O: \ 65 \ 65722-910515 DOC \ 4 -29-
567078 A7 B7 五、發明説明(27 ) 中,不會在暴露到電磁力期間或之後在任何的這些病人之 中觀察到不利或負面的副作用。透過本發明的方法與裝置 的包磁力應用顯示甚至在有心臟病的病人的心電圖上沒有 負面的效果。此治療在病人的運動肌、知覺神經功能、或 傳導上沒有任何不利的效果。 臨庆實验 下列是當運用在慢性傷害病歷的病人肢體時,證明本發 明治療功效的臨床實驗,這些慢性傷害先前對其他有療效 治療是沒有反應。 遵循美國食物藥品管理(階段丨研究)所定義的良好臨床實 ^扣導方針之一階段1協定係提供給juarez醫院機構覆審委 員會/道德規範委員會,並且在1995年9月24日核准。遵循 才々準的作業程序,以監督臨床實驗。總數4 2位病人會接受 研究。 下列臨床實驗是當運用在具慢性傷害病歷的病人肢體時 ,證明本發明治療的功效,慢性傷害在先前對其他有療效 治療與骨折的病人是沒有反應。 如下列所定義的電磁刺激是在2到8個月時間,一週7次, ,日2到3小時運用在手臂上。手臂的所有暴露的組織是在 靜电及/或時變磁場的組合效果下考慮。在手臂的每一段所 心、應的了文电场強度將根據法拉第定律隨著半徑改變。 “ 25位病人容許接受慢性腿潰瘍治療。每位病人的完整看 護兄錄係包含一簽字的自願同意書。他們的臨床病歷係包 括靜脈與動脈疾病的定義、其他潛在疾病、潰瘍病歷、及 O:\65\65722-910515 D〇C\567078 A7 B7 5. In the description of the invention (27), no adverse or negative side effects will be observed in any of these patients during or after exposure to electromagnetic forces. The magnetic field application by the method and device of the present invention shows that there is no negative effect even on the electrocardiogram of patients with heart disease. This treatment does not have any adverse effects on the patient's motor muscles, sensory nerve function, or conduction. Linqing experiment The following is a clinical experiment to prove the therapeutic efficacy of the present invention when applied to the limbs of patients with chronic injury medical records. These chronic injuries have not previously responded to other curative treatments. Following good clinical practice as defined by the US Food and Drug Administration (Phase 丨 Study) ^ One of the guidelines for Phase 1 was provided to the Juarez Hospital Institutional Review Board / Ethics Committee and was approved on September 24, 1995. Follow talented procedures to monitor clinical trials. A total of 42 patients will receive the study. The following clinical experiments demonstrate the efficacy of the treatment of the present invention when applied to the limbs of patients with a chronic injury medical history. Chronic injury has not previously responded to other curative and curative patients. Electromagnetic stimulation, as defined below, is applied to the arm 2 to 3 months, 7 times a week, 2 to 3 hours a day. All exposed tissues of the arm are considered under the combined effect of static and / or time-varying magnetic fields. The intensity of the applied electric field in each segment of the arm will change with the radius according to Faraday's law. "25 patients are allowed to be treated for chronic leg ulcers. Each patient's complete nursing record contains a signed voluntary consent form. Their clinical records include definitions of venous and arterial disease, other underlying diseases, ulcer medical records, and : \ 65 \ 65722-910515 D〇C \
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所使用的治療。只有在檢查時未受治療的傷害會追蹤。每 一潰瘍會透過攝影、大小、與大約的計算區域(長度χ寬度 )描述及證明。當超過一潰瘍存在時,一大約的總潰瘍區: 便可決定。實驗測試係包括血化學、血液檢試、心電圖、 及其他診斷測試。週邊的流通是透過都卜勒彩色超音波攝 影術,動脈X線攝影法、靜脈又光攝影術、與血液評估。追 蹤的記錄係包括慢性腿潰瘍病歷的一定期攝影記載、一週 臨床註釋、及身體檢查之一報告。 I.慢性靜脈腿清徭 除了腿潰瘍之外、原發性曲張靜脈、深血管栓塞、糖尿 病、高血壓、風濕性關節炎、肥胖與心臟血管疾病之外, 包括潛在疼痛的病人群會是伴隨腿溃瘍的疼痛、水腫感染 與有限制行動。 範J3 :原發性曲張靜脈的老婦人 病人編號1是受原發性曲張靜脈及有超過9個月6平方公分 腿潰瘍疼痛的一 75歲婦女。潰瘍會伴隨疼痛、水腫、與有 限活動。根據發明的電磁刺激然後可維持5個月每天大約2 小時運用在她任何一手臂。在此期間無需投予其他藥物治 療。 在治療的最初兩週之後,疼痛與水腫會消失,病人變得 完全可活動。溃瘍會以肉芽組織復原,且在電磁力治療開 始之後要整個治療5個月。如持續治療,病人對㈣的生活 及其記憶改善會變得更留心與樂觀。在溃癌復原之後,病 人可在觀察下保持進一步8個月時間,而且在所有此時間過 O:\65\65722-910515DOC\ 4 * 31 -The treatment used. Only untreated injuries will be tracked at the time of examination. Each ulcer will be described and proven by photography, size, and approximate calculated area (length x width). When more than one ulcer is present, an approximate total ulcer area: can be determined. Laboratory tests include blood chemistry, blood tests, electrocardiograms, and other diagnostic tests. Peripheral circulation is through Doppler color ultrasound, arterial tomography, vein and light photography, and blood evaluation. The track records consisted of a periodic photographic record of the chronic leg ulcer medical history, a week of clinical notes, and a report of a physical examination. I. Chronic venous leg depletion In addition to leg ulcers, primary varicose veins, deep vascular embolism, diabetes, hypertension, rheumatoid arthritis, obesity and cardiovascular disease, patients with potential pain will be accompanied Pain in leg ulcers, edema infections, and restricted movement. Fan J3: Elderly woman with primary varicose veins Patient number 1 is a 75-year-old woman affected by primary varicose veins and having leg ulcer pain over 9 months. Ulcers can be accompanied by pain, edema, and limited activity. The electromagnetic stimulation according to the invention can then be applied to any of her arms for about 2 hours per day for 5 months. No other medication is required during this period. After the first two weeks of treatment, pain and edema disappear and the patient becomes fully mobile. The ulcers will recover as granulation tissue and will be treated for the entire 5 months after the start of the electromagnetic force treatment. With continuous treatment, patients will become more attentive and optimistic about their life and memory improvement. After the cancer has recovered, the patient can remain under observation for a further 8 months, and all of this time will pass O: \ 65 \ 65722-910515DOC \ 4 * 31-
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程中,病人會保持沒有徵候。 蕊原發性曲張靜脈之年輕男子 病人編號2號是超過9個月在4平方公分腿溃瘍伴隨疼痛與 水腫的原發性曲張靜脈疼痛之—33歲男。根據本發明,電 磁刺激可在沒有額外治療於一週時間,每週5天,每天2】 時運用在他的手臂。 ^ 在治療開始後的一週,疼痛與水腫會消失,且潰瘍可在6 週之後出現完全復原,然而,當病人回診時,他在外傷而 非再發性所產生的所有表皮會出現新的腿潰瘍。 一第二連串電磁力治療然後可4天,每天2小時運用在他 任何-手臂。i口同第-次,第二治療可在一週内將 復原。 益例3一 :原發性曲張靜脈之年輕婦女 病人編號3是超過1年在6平方公分腿潰瘍受到原發性曲張 靜脈疼痛之一 66歲婦女。潰瘍會伴隨疼痛、水腫、與有限 活動。 她接受的唯一治療是維持3個月,每週3日,每天2小時運 用在她任何一手臂的電磁刺激。 在治療的最初2個週之後,疼痛與水腫會消失,且病人會 變得可完全活動。在治療開始之後的3個月,治療可提高肉 芽組織的生長及在她的腿上減少大約4 8 %潰傷區域。 範例6 :深血管栓塞的年輕女子 病人編號4是超過8年受深血管栓塞及超過7年的6平方公 分潰瘍疼痛之一3 8歲婦女。潰瘍會伴隨疼痛、水腫、與有 O:\65\65722-910515 DOC\ 4 -32-During the course, the patient will remain without symptoms. Young man with primary varicose veins Patient No. 2 is a 33-year-old male with primary varicose vein pain with pain and edema in a 4 cm cm leg ulcer over 9 months. According to the present invention, the electromagnetic stimulation can be applied to his arm 2 days a week, 5 days a week without additional treatment. ^ One week after the start of treatment, the pain and edema will disappear, and the ulcer will fully recover after 6 weeks. However, when the patient returns, he will have new legs in all the epidermis caused by trauma rather than recurrence. ulcer. A second series of electromagnetic force treatments can then be applied to any of his arms for 4 days, 2 hours a day. I mouth is the same as the first time, and the second treatment can recover within one week. Example 31: Young woman with primary varicose veins Patient number 3 is one of 66-year-old women who has suffered from primary varicose vein pain in a leg ulcer of 6 cm in length over 1 year. Ulcers can be accompanied by pain, edema, and limited activity. The only treatment she received was for 3 months, 3 days a week, 2 hours a day using electromagnetic stimulation on any of her arms. After the first 2 weeks of treatment, pain and edema will disappear and the patient will become fully mobile. 3 months after the start of the treatment, the treatment increased the growth of granulation tissue and reduced her wound area by about 48%. Example 6: Young woman with deep vascular embolism Patient number 4 is one of the 38-year-old women who has suffered from deep vascular embolism for more than 8 years and a 6 cm² ulcer for more than 7 years. Ulcers are accompanied by pain, edema, and O: \ 65 \ 65722-910515 DOC \ 4 -32-
567〇78 A7 B7 五 、發明説明(30 ) 限活動。在這段時間’病人可接受特定醫療與外科治療, 二括fe靜脈切除術與皮膚接枝程序,以及將繃帶運用在潰 瘍之行動性應用,但是他們不能改善她的狀況。 根據本發明的電磁刺激可維持5個月,每週5天,每天2小 =然後運用在她任何一手臂。在這段時間,病人可在電磁 治療之前持續在她的腿潰瘍上使用她鬆綁的行動性繃帶。 在’η療的最初兩週之後,疼痛與水腫會消失,且在6個週 <後,她會變得可完全活動。在治療的5個月之後,潰瘍底 部是表面的,且它的大小會減少大約8 〇 %。 範ϋ 7 :深血管栓塞與表面靜脈機能不全的中年婦女 病人編號5是在兩下部肢體超過7年慢性腿潰瘍受深血管 检塞與表面靜脈機能不全疼痛之一肥胖41歲婦女。潰傷區 域伴隨疼痛、水腫、發癢、與有限活動。在這段時間,她 接受區域與系統醫療,以及在改善她情況無效的兩腿實施 Litton# ^ 白勺 ϋ 〇 電磁刺激然後在每週3天,每天2小時運用在她任何一手 臂。在治療的最初兩週之後,疼痛與水腫會消失,且在兩 個月内,潰瘍可完全復原,且電磁力暴露可暫時中止。4個 月後’潰瘍會保持復原,且病人會沒有徵候。 範Hi:深度與表面靜脈機能不全與動脈高血壓的中年婦女 病人編號6是超過1年半慢性腿潰瘍受深度與表面靜脈機 能不全與動脈高血壓疼痛之一肥胖59歲婦女。潰癌會伴隨 疼痛與水腫、一大區域的紅斑、與有限活動。在這段時間 ’動脈高血壓可在控制下保持,且潰瘍可使用不能有效改 O:\65\65722-910515.DOC\ 4 -33- 本紙張尺度適用中國國家標準(CNS) A4規格(210X297公釐)567〇78 A7 B7 V. Description of the invention (30) Limit activities. During this time, the patient could receive specific medical and surgical treatments, including venous excision and skin grafting procedures, and mobile applications of bandages on ulcers, but they could not improve her condition. The electromagnetic stimulation according to the present invention can be maintained for 5 months, 5 days a week, 2 hours a day = and then applied to any of her arms. During this time, the patient can continue to use her loose bandage on her leg ulcers before electromagnetic therapy. After the first two weeks of 'η treatment, the pain and edema will disappear, and after 6 weeks < she will become fully mobile. After 5 months of treatment, the base of the ulcer is superficial and its size will be reduced by about 80%. Fan Ye 7: Middle-aged women with deep vascular embolism and superficial venous insufficiency. Patient number 5 is an obese 41-year-old woman suffering from deep vascular embolism and superficial venous insufficiency in both lower limbs for more than 7 years. The wounded area is accompanied by pain, edema, itching, and limited activity. During this time, she received regional and systemic medical treatment, as well as Litton # ^ 〇 〇 〇 Electromagnetic stimulation was applied to her two arms that were ineffective in improving her condition, and then applied to any of her arms 2 hours a day, 3 days a week. After the first two weeks of treatment, the pain and edema disappear, and within two months, the ulcers can fully recover, and the electromagnetic force exposure can be temporarily suspended. After 4 months, the ulcer will recover and the patient will have no symptoms. Fan Hi: Middle-aged woman with deep and superficial venous insufficiency and arterial hypertension Patient number 6 is an obese 59-year-old woman who is one of the chronic leg ulcers suffering from deep and superficial venous insufficiency and arterial hypertension pain for more than 1 year. Cancer ulcers are accompanied by pain and edema, large areas of erythema, and limited activity. During this time, arterial hypertension can be maintained under control, and the ulcer can be used and cannot be effectively changed. O: \ 65 \ 65722-910515.DOC \ 4 -33- This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 (Mm)
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線 567078 A7 B7 五、發明説明(31 ) 善她情況的傳統醫療與外科治療處置。 電磁刺激然後可大約2個月,每週3天,每天2小時運用在 她任何一手臂,而她可持續同前接受相同的抗高血壓治療 。在電磁治療的最初兩週之後,疼痛與水腫會消失,且潰 瘍會在3週内受到結疤的覆蓋。紅斑的區域可在4週内減少 ’且結症會開始脫落由留下傷痕的組織所取代。 範例9 :淋巴腺與表面靜脈機能不全的女性 病人編號7是當她2歲時在她左腿所造成的淋巴腺與表面 靜脈機能不全疼痛之一 42歲婦女。此外,,她在整個395平 方公分腿上擴大的潰傷區域超過5年時間,其伴隨疼痛、水 腫、與有限活動。在這段時間,她曾經接受壓縮力行動性 繃帶、醫療、與外科治纟,包括不能有效改善她情況的皮 膚接枝。 電磁刺激根據本發明然後可在超過6個月,每週5天,每 天2小時運用在她任何-手臂。在此治療過程中,她可持續 使用在電磁治療之前所使用的鬆綁移動性繃仙 額外治療要投予在她身上。 / 、 在電磁治療兩週之後,疼痛與水腫會消失,且在4到8週 (後,她會變得可完全活動。在電磁治療的々到了週之後, 血管生成可透過在溃傷區域上足夠的肉芽組織出現而顯現 。在第8週,她會變得可完全活動。在治療的?個月 傷害可完全德屈。 1例1 0 :表面靜脈機能不全的婦女 病人編號8是超過7年具7平方公分腿溃I的表面靜脈機能 O:\65\65722-910515 DOC\ 4 -34 -Line 567078 A7 B7 V. Description of the invention (31) Traditional medical and surgical treatment for her condition. The electromagnetic stimulation can then be applied to any of her arms for about 2 months, 3 days a week, 2 hours a day, and she can continue to receive the same antihypertensive treatment as before. After the first two weeks of electromagnetic therapy, pain and edema will disappear and the ulcer will be covered by scars within 3 weeks. The area of erythema can be reduced within 4 weeks and the disease will begin to fall off and be replaced by the tissue that left the scar. Example 9: A woman with lymphadenopathy and superficial venous insufficiency Patient number 7 is one of the pains of lymphadenopathy and superficial venous insufficiency caused by her left leg when she was 2 years old. A 42-year-old woman. In addition, she had an enlarged wound area over the entire 395 cm leg for more than 5 years, accompanied by pain, edema, and limited movement. During this time, she had undergone compressive mobile bandages, medical treatments, and surgical interventions, including skin grafts that did not improve her condition effectively. Electromagnetic stimulation according to the present invention can then be applied to any of her arms for more than 6 months, 5 days a week, 2 hours a day. During this treatment, she can continue to use the loose loose mobile stretcher used before the electromagnetic treatment. Additional treatment is given to her. /, After two weeks of electromagnetic treatment, the pain and edema will disappear, and after 4 to 8 weeks (after that, she will become fully mobile. After the week of electromagnetic treatment, angiogenesis can penetrate the wound area Enough granulation tissue appeared and appeared. At week 8, she would become fully mobile. In the treatment? Month of injury can be completely decumbent. 1 case 1 0: the number of women with superficial venous insufficiency number 8 is more than 7 Surface vein function with 7 cm 2 leg ulceration I: \ 65 \ 65722-910515 DOC \ 4 -34-
567078 A7 ______ B7_. _ 五、發明説明(32 ) 不全之一 52歲婦女。潰瘍會伴隨疼痛、水腫、感染、與有 限活動。電磁刺激可維持兩個月,每週3天,每天2小時運 用在她任何一手臂。在這段時間無需投予其他治療。 疼痛與水腫會在病人變成可完全活動的治療第一週之後 消失。潰瘍大小會在治療的1個月之後減少超過9 5 〇/0。 範-例1 1 :表面靜脈機能不全的老年婦女 病人編號9是超過15年受表面靜脈機能不全與一慢性腿溃 癌疼痛足一 62歲婦女。在允許研究潰瘍疤痕之前的一週會 變得非常疼痛,這時產生血漿流出的〇·5平方公分潰傷區域 。私磁刺激然後可在兩週,每週3天,每天2小時運用在她 任何一手臂。潰瘍可在3日内復原,且病人在次月會保持沒 有徵候。 i例1 2 ··表面靜脈機能不全人工潰瘍與神經憂鬱的中年婦女 病人編號1 0是超過2 1年由病人所維持大約2 5平方公分的 兩腿潰瘍疼痛之一 51歲婦女。傷害會伴隨疼痛、水腫、與 有限活動。在這段時間,病人已進行醫療,但是它不能有 效治療她的狀況。根據本發明,電磁刺激然後可在2個月, 每週3天,每天2小時運用在病人的手臂。在這段時間無需 對他投予其他治療。 在治療的4週之後,疼痛與水腫會消失,且在治療的^個 月之後,潰瘍可減少大約3 2 %。 Ι·1與限制有益效果的慢性靜脈腿潰瘍、及/或靜脈疾疒 關的病理學 > f 除了慢性腿潰瘍與靜脈疾病、非水腫傷痕之外,, 群體 O:\65\65722-910515.DOC\ 4 -35-567078 A7 ______ B7_. _ V. Description of the invention (32) One of the incomplete 52-year-old woman. Ulcers can be accompanied by pain, edema, infection, and limited activity. The electromagnetic stimulation can be maintained for two months, 3 days a week, and applied to any of her arms 2 hours a day. No other treatment is needed during this time. Pain and edema will disappear after the first week of the patient becoming fully mobile. Ulcer size will decrease by more than 95/0 after 1 month of treatment. Fan-Example 1 1: Elderly women with superficial venous insufficiency Patient number 9 is a 62-year-old woman who has suffered superficial venous insufficiency with a chronic leg ulcer and pain for more than 15 years. The week before ulcer scars are allowed to study can become very painful, at which point a 0.5 cm² area of plasma bleed is produced. Private magnetic stimulation can then be applied to any of her arms for two weeks, three days a week, two hours a day. The ulcer can recover within 3 days, and the patient will remain asymptomatic the following month. Case 1 2 ·· Middle-aged woman with superficial venous insufficiency, artificial ulcer and neurodepression. Patient No. 10 is one of the painful leg ulcers that has been maintained by the patient for approximately 25 square centimeters over 21 years. A 51-year-old woman. Injuries can be accompanied by pain, edema, and limited activity. During this time, the patient has undergone medical treatment, but it cannot effectively treat her condition. According to the invention, the electromagnetic stimulation can then be applied to the patient's arm for 2 months, 3 days a week, 2 hours a day. No other treatment is required during this time. After 4 weeks of treatment, the pain and edema will disappear, and after ^ months of treatment, the ulcer can be reduced by about 32%. 1.1. Pathology of chronic venous leg ulcers and / or venous diseases with limited beneficial effects > f In addition to chronic leg ulcers and venous diseases, non-edema scars, group O: \ 65 \ 65722-910515 .DOC \ 4 -35-
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包括具非常高身體質量指數(超過4〇公斤/M2)與皮膚壞疽 之肥胖潛在疼痛病人。疼痛、水腫、與感染會伴隨慢性腿 潰瘍。 軏"魁】3 •表面及深部靜脈機能不全,非使水腫有傷痕,肥 胖及慢性靜脈腿溃瘍 此,例係描述一群4位病人的治療。病人(病人編號11-14)是9至17年受表面、及/或深部靜脈機能不全、肌肉結食 水腫、肥胖、與慢性靜脈腿潰瘍疼痛的5 6到7丨歲的一位婦 女及三位男子。所有病人已預防性使用目前建議醫療與外 科手術,以減緩靜脈高血壓、及/或使用皮膚接枝覆蓋在潰 傷區域。所有的這些治療對於改善他們的情況是無助益的 〇 根據本發明的電磁刺激然後可每週3天,每天2小時運用 在每位病人1 1至1 4的任何手臂上。在電磁力治療開始後面 的兩週’疼痛會減少,且潰瘍會看似變乾及深。這些變化 可暫時改善病人的情況,然而,潰瘍的大小保持相同,且 在某些心況會在電磁力治療期間增加潰瘍的大小。這些病 人可從記錄去除。 -㈣Μ :嚴重表面靜脈機能不全、高體質指數及慢性靜脈 腿潰癌的肥胖婦女 病人編號15是受表面靜脈機能不全疼痛之一 46歲婦女, 既然她疋13歲’非常南體質指標(超過4〇公斤/ jy[2)及在她 左腿非常疼痛的大慢性靜脈腿潰療已超過4年的一段時間。 在這段時間,她在特別中心接受預防措施及建議的醫療而 -36- O:\65\65722-910515.DOC\ 4 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐) 567078 A7Includes obese potentially painful patients with very high body mass index (over 40 kg / M2) and skin gangrene. Pain, edema, and infection are associated with chronic leg ulcers.魁 " Qui】 3 • Surface and deep venous insufficiency, not scarring of edema, obesity and chronic venous leg ulcers. This example describes the treatment of a group of 4 patients. The patient (patient numbers 11-14) was a woman aged 6 to 7 years old who suffered from superficial and / or deep venous insufficiency, edema of muscles, obesity, and chronic venous leg ulcers from 9 to 17 years. Men. All patients have been prophylactically used. Medical and surgical procedures are currently recommended to reduce venous hypertension and / or use skin grafts to cover the wounded area. All of these treatments are not helpful in improving their condition. The electromagnetic stimulation according to the present invention can then be applied to any arm of 11 to 14 per patient, 2 hours a day, 3 days a week. Two weeks after the start of the electromagnetic force treatment, the pain will decrease and the ulcers will appear dry and deep. These changes can temporarily improve the patient's condition, however, the size of the ulcer remains the same, and in some heart conditions can increase the size of the ulcer during electromagnetic force treatment. These patients can be removed from the record. -㈣Μ: Obese women with severe superficial venous insufficiency, high body mass index, and chronic venous leg ulcers. Patient number 15 is a 46-year-old woman suffering from superficial venous insufficiency. Since she is 13 years old, she has a very southern physical index (more than 4 〇kg / jy [2) and the large chronic venous leg ulcer with pain in her left leg has been treated for more than 4 years. During this time, she received preventive measures and recommended medical treatment in the special center. -36- O: \ 65 \ 65722-910515.DOC \ 4 This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) ) 567078 A7
禾 月匕?文善她的狀況。 根據本發明的電磁刺激然後在4個月车 .0 τ 乃時間,每週3天,每 小時運用在她任何一手臂。在電磁 由、 你私概力治療開始後的兩週 ’:踊會減少,流出物停止,且潰癌邊緣看似發炎'然而 =場的大小會在電磁力期間治療時期保持相同。此病人 曰伙_ έ己錄去除。 範深血管栓塞及皮膚壞疽的中年婦女 病人編號16是超過4年時間在她右腿後部受深血管栓塞與 兩不正^ /貝瘍疼痛之一 4 6歲婦女。在這段時間,她在特別 中心接受預防措施及建議的醫療,而未改善她的狀況。 根據本發明的電磁刺激然後4個月時間,每週3天,每天2 小時運用在她任何一手臂。在電磁力治療開始後的兩週, 疼痛會減少,且該等溃瘍之其中一者會變成表面。在此之 後’ >貝瘍會開始形成’而且病人會從記錄取除。一皮膚活 組織檢查變化會與病人醫療的皮膚壞疽相符。 Π·動脈腿潰疡 此群體是由除了慢性動脈腿潰瘍之外的一般動脈硬化、 糖尿病、動脈、及/或靜脈高血壓、風濕性關節炎、肥胖、 心臟血管疾病與脈管壞疽潛在性疼痛的病人所組成。殘餘 的疼痛、水腫感染與有限活動會伴隨腿潰瘍。 範例1 6 :嚴重腿局部貧血及糖尿病之老婦女 病人編號1 7是超過4個月時間在她左腿上伴隨強烈疼痛的 22平方公分潰傷區域受3個動脈潰癌與糖尿病疼痛之一 歲老婦女,此強烈疼痛可使病人在晚上睡覺避免。在這段 -37- O:\65\65722-910515 DOC\ 4 本纸張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐) 567078 A7Wo Moon Dagger? Wenshan is in her condition. The electromagnetic stimulus according to the present invention is then used for 4 months. 0τ is time, 3 days a week, applied to any one of her arms every hour. In the two weeks after the start of the electromagnetic therapy, 踊: 踊 will decrease, the effluent will stop, and the edge of the cancer will appear to be inflamed '. However, the size of the field will remain the same during the electromagnetic force during the treatment period. This patient called Huo _ Ji Ji Lu removed. Middle-aged woman with deep vascular embolism and cutaneous gangrene Patient number 16 is one of those who suffered from deep vascular embolism and pain in the back of her right leg for more than 4 years. During this time, she received preventive measures and recommended medical treatment in the special centre without improving her condition. The electromagnetic stimulation according to the present invention was then applied to any of her arms for 4 months, 3 days a week, 2 hours a day. Two weeks after the start of the electromagnetic force treatment, the pain will decrease and one of these ulcers will become superficial. After that ' ' Beiyang will begin to form ' and the patient will be removed from the record. A skin biopsy change will be consistent with the patient's medical skin gangrene. Π · Arterial leg ulcers This group is caused by general arteriosclerosis, diabetes, arterial and / or venous hypertension, rheumatoid arthritis, obesity, cardiovascular disease and vascular gangrene potential pain in addition to chronic arterial leg ulcers Of patients. Residual pain, edema infections, and limited activity are accompanied by leg ulcers. Example 16: Old woman patient with severe partial anemia and diabetes patient number 17 is one year old who suffers from 3 arterial ulcers and diabetic pain in a 22 cm 2 wound area with severe pain on her left leg over 4 months Old women, this intense pain prevents patients from sleeping at night. In this paragraph -37- O: \ 65 \ 65722-910515 DOC \ 4 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 567078 A7
時間’她接受醫療,但是㈣於改善她的狀沉是無效的。 根據本發明的電磁刺激然後可在7個月時間,每週4天, 每天3小時運用在她人何一手臂。在這段時間,他無需投予 其他治療。 在4週的治療之後,皮膚溫度會增加’且表面血管會變得 更顯著的反應增加脈管生成。潰瘍底部顯示反應增加血管 生成的豐富肉芽組織。疼痛可明顯減少,使病人可在晚上 睡覺。在電磁治療的7個月之後,3個潰瘍可完全復原。在 這段時間,病人的神經敏捷與記憶會明顯改善。這位病人 追蹤額外的一年。在這段時間,潰瘍會保持復原。 範1LLL:風濕性關節炎及動脈硬化的老婦女 主病人編號U是與風濕性關節炎及動脈硬化有關的兩動脈 潰瘍疼痛之-8G歲婦女4膝外科手術之後,潰傷區域是 由彈性長襪所產生的大約35平方公分。這些傷害存在㈠個 月且在晚上會伴隨使病人醒著的強烈疼_。皮膚接枝與 ,物治療無法有效改善她的狀況。根據本發明的電磁刺激 ^在4個半月時間,每週3天,每天3小時施加在她任何一手 臂。在這段時間不投予其他治療。 在電磁治療疼痛開始後的四週會減少,使病人可在晚上 ,覺:皮;f溫度會增力口 ’且表面血管會更明顯反應增加脈 管生成。潰瘍底部會反應增加血管生成的豐富肉芽組織。 在兩個月中,病人沒有疼痛,且潰傷區域可在4個半月完全 復原。在這段時間,病人會變得更敏覺,狂熱及她的記憶 可改善。病人會追蹤額外8個月。在這段時間,潰瘍會保持 O:\65\65722-910515DOC\ 4 -38- 五、發明説明(36 復原。 範例1 8〜:有一般動脈硬化的高齡男子 病人編號19是在他腿前部由一般動脈硬化所引起兩年慢 性動脈潰癌65平方公分有疼痛之一 7〇歲男子。大腿骨動脈 机月(1 u m e η)會減少8 5 %,且前脛骨動脈流明具有9 〇 %狹 窄。溃,會伴隨在晚上保持使病人醒著的強烈疼痛❶皮膚 接枝與藥物治療五法有效改善他的狀況。 根據本發明的電磁刺激在12個月時間,每週3天,每天3 小時運用在他任何-手臂。在這段時間無需投其他治療。 在治療的兩週之後,溃瘍底部會發紅,而且肌腱會上皮 化,疼痛會明顯減少,使病人可在晚上睡覺及改善活動。 在皮膚溫度增加的兩個半月後,表面血管會變更明顯反應 增加脈管生成。潰瘍底部顯示反應增加血管生成的幽舍 芽組織,且病人會沒有疼痛。在這段時間,病人會;:更 樂觀 '敏覺’且他的心情可明顯改善。在治療的12月之前 在他腿上的潰傷表面區域的整體減少是大約8 〇 %。 範—般動脈硬化、表面與深部靜脈機能不全及風濕 性關節炎之婦女 病人編號20疋丈一般動脈硬化、表面與深部靜脈機能不 全及風濕性關節炎疼痛之一 57歲婦女。此外,她有9個月舊 潰瘍。在她腿前部的一潰傷區域6·5平方公分,及另一是i 平万公分的中度足踝潰瘍。電磁刺激然後可在大約7個月時 間,每週4天,每天3小時運用在病人任何一手臂。在這段 時間無需投予其他治療。 ° O:\65\65722-910515 DOC\ 4 五、發明説明(37 ) 在電磁治療的3個月之後,中度足.躁溃癌會復原,且在她 腿前部的潰瘍會在7個月内復原。在這段時間可改善她憂參 心情。 無ϋϋ:脈管壞疽的中年婦女 病人編號是受-石夕深植造成右腿脈管壞症疼痛之一45 歲老婦女。重建外科手㈣切斷拯救她的腿κ吏用 -堅固人X修復術在另—腿的後部巾_域導致動脈閉塞 後的兩年,造成持續超過5個月的—非常疼痛23平方公分溃 瘍。疼痛與水腫會㈣溃H她的活動受限制。在這段 時間’她接受醫療,但是無法減輕她的狀況。在電磁治療 運用給病人之前,當她的溃瘍清料,她需要局部麻醉’。、 電磁刺激會在超過2個月時間,每週5天,每天i小時運用在 她的手f ’在這段日寺間,她的潰癌㈣天清潔。在這段時 間無需投予其他治療。 生在…療的4週《後,疼痛與水腫會消失,不再施麻醉清潔 :瘍’且4人會變得可完全活動。纟治療的2個月之後,在 潰瘍底部出現的肉芽組織與潰瘍可完全復原。 ^例2 1 _ ·典法控制的動脈高血壓及深血管栓塞之中年男子 、病人編號22是超過7年整個2〇平方公分慢性腿潰癢的無 法控制動脈高血壓與深血管栓塞疼痛之一 54歲男子。潰傷 區域會伴隨疼痛、水腫、與有限活動。在這段時間,他接 收,療,^括抗高血壓治療,但是無法改善他的狀況。 當他持續接受同前的相同抗高血壓治療時,電磁刺激蚨 後可在大約4個月日寺間,每週3天,每天2小時運用在他任何Time ’, she received medical treatment, but she was ineffective in improving her condition. The electromagnetic stimulation according to the present invention can then be applied to her arm for 7 months, 4 days a week, 3 hours a day. During this time, he does not need to administer additional treatment. After 4 weeks of treatment, the skin temperature will increase 'and the superficial blood vessels will become more prominent in response to increased angiogenesis. The bottom of the ulcer shows a rich granulation tissue that responds to increased angiogenesis. Pain can be significantly reduced, allowing patients to sleep at night. After 7 months of electromagnetic treatment, the 3 ulcers were fully recovered. During this time, the patient's neural agility and memory will improve significantly. This patient tracked for another year. During this time, the ulcer will remain healing. Fan 1LLL: The main patient number of old women with rheumatoid arthritis and arteriosclerosis is U. Pain in two arterial ulcers associated with rheumatoid arthritis and arteriosclerosis. -8G-year-old woman. 4 knee surgery. The socks produced about 35 square centimeters. These injuries persist for up to two months and are accompanied by intense pain that wakes the patient up at night. Grafting of the skin and skin treatment could not effectively improve her condition. The electromagnetic stimulation according to the present invention was applied to any of her arms for 4 and a half months, 3 days a week, 3 hours a day. No other treatment was given during this time. Four weeks after the start of electromagnetic treatment of pain will be reduced, so that patients can feel at night: skin; f temperature will increase the mouth 'and the surface vessels will respond more significantly to increase angiogenesis. The bottom of the ulcer responds to the rich granulation tissue that increases angiogenesis. Within two months, the patient had no pain and the wounded area fully recovered in 4 1/2 months. During this time, the patient becomes more sensitive, her fever and her memory can improve. Patients will be followed for an additional 8 months. During this time, the ulcer will remain O: \ 65 \ 65722-910515DOC \ 4 -38- V. Description of the invention (36 recovery. Example 1 8 ~: Older male patient with general arteriosclerosis No. 19 is on the front of his leg A 70-year-old man suffering from chronic arteriosclerosis caused by general arteriosclerosis in 65 square centimeters for two years. The femoral arterial machine (1 ume η) will be reduced by 85%, and the anterior tibial artery lumens will be 90% narrow. The ulceration will be accompanied by the intense pain that keeps the patient awake at night. The five methods of skin grafting and drug treatment effectively improve his condition. The electromagnetic stimulation according to the invention is 12 months, 3 days a week, and 3 hours a day. Used in any arm of him. No other treatment is needed during this time. After two weeks of treatment, the bottom of the ulcer will be red, and the tendon will be epithelialized, and the pain will be significantly reduced, allowing the patient to sleep at night and improve activity. Two and a half months after the skin temperature increases, the superficial blood vessels will change significantly to increase angiogenesis. The bottom of the ulcer shows a reaction that increases angiogenesis of the pyloric bud tissue and the patient will have no pain. At this time In the meantime, the patient will be: more optimistic 'mind sense' and his mood can be significantly improved. The overall reduction in the area of the wound surface on his leg before December of the treatment was about 80%. Fan-like arteriosclerosis, A patient with a superficial and deep venous insufficiency and rheumatoid arthritis, patient number 20, a 57-year-old woman with general arteriosclerosis, superficial and deep venous insufficiency, and rheumatoid arthritis pain. In addition, she has a 9 month old ulcer. An area of 6.5 square centimeters in the front of her leg, and another moderate foot and ankle ulcer of 10,000 square centimeters. Electromagnetic stimulation was then available for about 7 months, 4 days a week, and 3 hours a day. Apply to any arm of the patient. No other treatment is required during this time. ° O: \ 65 \ 65722-910515 DOC \ 4 V. Description of the invention (37) After 3 months of electromagnetic therapy, moderate foot. Manic The cancer will recover, and the ulcers in the front of her legs will heal within 7 months. During this time, her mood will be improved. WU: The middle-aged woman patient with vascular gangrene is affected by-Shi Xishen One of 45-year-old women suffering from pain in the right leg with vascular necrosis. Reconstructive Surgical Surgery to Cut and Rescue Her Legs-Reliable Man X Prosthesis in the Other-The posterior leg of the leg leads to arterial occlusion two years later, resulting in a pain lasting more than 5 months-very painful 23 cm cm ulcer . Pain and edema will frustrate her. Her movements are restricted. During this time 'she received medical treatment but could not relieve her condition. Before electromagnetic therapy was applied to the patient, she needed local anesthesia when her ulcer was cleared' 、 The electromagnetic stimulation will be applied to her hand for 5 hours a day, 5 hours a week, i hours a day. 'During this period, her cancer will be cleaned every day. No other investment is required during this time. Treatment. Born after 4 weeks of treatment, the pain and edema will disappear, no more anesthesia cleaning: ulcers, and 4 people will become fully mobile. After 2 months of treatment, the granulation tissue and ulcers appearing at the bottom of the ulcer can completely recover. ^ Example 2 1 _ · Arterial hypertension and deep vascular embolism controlled by code law Middle-aged man, patient number 22 is a chronic leg itch of 20 cm 2 in length that cannot control arterial hypertension and deep vascular embolism pain over 7 years A 54 year old man. The wounded area is accompanied by pain, edema, and limited movement. During this time, he received treatment, including antihypertensive treatment, but was unable to improve his condition. When he continues to receive the same antihypertensive treatment as before, the electromagnetic stimulation can be applied to the temple for about 4 months, 3 days a week, and 2 hours a day.
本紙張尺度適财® ®家 297公釐) 567078The paper size is suitable for wealth ® ® 297 mm) 567078
一手臂。 在治療的最初3週之後,潰瘍疼痛、水腫、與壞死會消失 。在6週的治療之後,他可變成完全活動,且潰瘍可在治療 的3個月内完全復原。 範:無法控制的動脈高血壓、表面靜脈機能不全、控 制類型2糖尿病及肥胖的女性 病人編號23號是超過2年及期他超過3個月的整個u平方 公分的兩腿潰瘍之一 60歲老婦人。在這段時間,她接受包 括抗高血壓治療的醫學處置,但是它無法改善她的狀況。 根據本方法的電磁刺激然後可在她接受持續抗高血签治 療期間,維持4個半月時間,每週3天,每天3小時運用她任 何一手臂。在電磁治療期間,病人會發展成由外傷所產生 的一第三度傷害。 在治療的一週之後,疼痛、水腫、與3個月久的腿潰瘍會 消失。在6週電磁治療之後,由隨後外傷所造成的傷害會復 原。病人允許額外一年,且潰瘍可保持復原。 範_例2 3.: 一般動脈硬化的老婦人 病人編號2 4是超過1年的一般動脈硬化及一慢性腿潰瘍 1.2平方公分疼痛之一 85歲老婦人。在這段時間,她接受建 議醫療,但是無法減輕她的狀況。 根據本方法的電磁刺激可在2個月時間,每週5天,每天2 小時運用在她任何一手臂。在2週的治療之後,疼痛與水腫 會消失。這些變化會在增長肉芽組織潰瘍附近的炎症反應 敏感之後出現,其涵蓋反應增加血管生成的潰瘍底部。在3 -41 - O:\65\65722-910515.DOC\ 4 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公爱) 567078 A7 * ___B7 五、發明説明(39 ) ---一~—-~- 個月中,潰傷區域可減少超過7〇%。 •共法控制類型!糖尿病及血中膽固醇過高的 男子 病人編號25疋他左腳上已有3個月足底潰瘍疼痛的無法控 制類型1糖尿病及血中膽固醇過高之24歲男子。病人接受局 4外科與醫療無法有效減輕他的狀況。電磁刺激可在超過2 個月時間,每週5天,每天2小時運用在他任何一手臂。在3 ㈣治療之後,深潰癌底部是在皮膚表面上。潰瘍可在4週 凡全復原。病人需額外4個月保持沒有徵候。 ΙΠ·壓迫潰癌色 此群I括除了壓追溃瘍之外的半身不遂、深血管检塞、 與肥胖潛在性疼痛之病人。壓追潰癌會伴隨 與感染。 範腿傷的中年失禁半身麻痺的婦女 病人編號26是有2個傷害的一64歲半身麻痒與失禁的婦 女。在她左腿上的24平方公分傷害是由嘗試外科復原-電 毯爱傷產生’而且是6個月時間。第二傷害是4個月時時間 ’階段5 Yark0ny-Kirk分類臥姿荐骨潰瘍。在這段時間,她 接,系統抗生素治療’而且3次嘗試進行外科復原她的傷害 。這些治療無法改善她的狀況。電磁刺激然後可在超過8個 半月時間’每週7天,每天6小時運用在她任何—手臂。病 人接受護士每天24小時照料,及持續接受有系統的抗生素 治療。在這段時間無需投予其他額外傷害治療。 在電磁治療腿傷害復原的6週之後,狄姿潰癌感染可受控 O:\65\65722-910515.DOC\ 4 -42- 567078 A7 B7One arm. Ulcer pain, edema, and necrosis will disappear after the first 3 weeks of treatment. After 6 weeks of treatment, he can become fully active and the ulcers can fully recover within 3 months of treatment. Fan: Uncontrollable arterial hypertension, superficial venous insufficiency, and type 2 diabetes and obesity. Female patient number 23 is one of the two square feet ulcers of more than 2 years and 3 months in length. He is 60 years old. Old woman. During this time, she received medical treatment including antihypertensive treatment, but it did not improve her condition. The electromagnetic stimulation according to this method can then be maintained for 4 and a half months during her antihypertensive treatment with 3 days a week and 3 hours a day using any of her arms. During electromagnetic therapy, the patient develops a third-degree injury from trauma. After one week of treatment, pain, edema, and leg ulcers that are 3 months old will disappear. After 6 weeks of electromagnetic therapy, the injuries caused by subsequent trauma will be restored. The patient is allowed for an additional year and the ulcer can remain recovered. Fan_Example 2 3 .: Old woman with general arteriosclerosis Patient number 24 is one of the common arteriosclerosis and a chronic leg ulcer with a pain of 1.2 square centimeters more than one year old 85-year-old woman. During this time, she received medical advice but was unable to alleviate her condition. The electromagnetic stimulation according to this method can be applied to any of her arms for 2 months, 5 days a week, 2 hours a day. After 2 weeks of treatment, the pain and edema will disappear. These changes occur after a sensitive inflammatory response near the growth of granulation tissue ulcers, which covers the bottom of the ulcer that increases angiogenesis. In 3 -41-O: \ 65 \ 65722-910515.DOC \ 4 This paper size applies Chinese National Standard (CNS) A4 specification (210 X 297 public love) 567078 A7 * ___B7 V. Description of invention (39) --- Within a month, the area of ulceration can be reduced by more than 70%. • Common law control type! Diabetes and Hypercholesterolemia in Men Patient No. 25: A 24-year-old man with uncontrollable type 1 diabetes and hypercholesterolemia in his left foot for 3 months. The patient received Bureau 4 Surgery and medical treatment could not effectively alleviate his condition. Electromagnetic stimulation can be applied to any of his arms for 2 hours, 5 days a week, 2 hours a day. After 3 hours of treatment, the bottom of the deep ulcer is on the skin surface. Ulcers can be fully recovered in 4 weeks. Patients need to remain unsymbolized for an additional 4 months. III. Compression rupture cancer group This group includes patients with hemiplegia, deep blood vessel embolism, and obesity-related pain in addition to the pressure ulcer. Pursuing cancer can be accompanied by infection. Middle-aged Incontinence Hemiplegia Woman with Fan Leg Injury Patient No. 26 is a 64-year-old half-body itching and incontinence woman with 2 injuries. The 24cm injury on her left leg was caused by an attempted surgical recovery-electric blanket love injury 'and it took 6 months. The second injury was at the time of 4 months. Stage 5 Yark0ny-Kirk classification sacral ulcer in a lying position. During this time, she received systematic antibiotic treatment ’and 3 attempts to surgically recover her injuries. These treatments did not improve her condition. The electromagnetic stimulation can then be applied to any of her arms for more than 8 1/2 months' 7 days a week, 6 hours a day. Patients receive nurses 24 hours a day and continuous systemic antibiotic treatment. No additional injury treatment is required during this time. After 6 weeks of leg healing with electromagnetic therapy, Dizi's cancer infection can be controlled O: \ 65 \ 65722-910515.DOC \ 4 -42- 567078 A7 B7
五、發明説明(4〇 )V. Description of the invention (40)
在額外3 ill雷磁治卷S接,al /台〜—山— 域會在At the additional 3 ill, the magnetic field is connected to S, al / tai ~ — 山 — domain will be in
最後會消失。在額外3個月電磁治療之後, 臥姿潰瘍便可完 全復原。 範壓迫潰瘍及深血管栓塞的老婦女 病人編號2 7是每天8到1 2小時坐在相同位置上,受深血 管栓塞疼痛造成她左坐骨結節產生一18個月時間6〇平方公 分非常疼痛的水腫、出血、易碎、紫色錠狀、高度壓迫潰 瘍之一肥胖90歲高齡婦女。疼痛與水腫會伴隨潰瘍。在這 段時間,病人接受醫療包括區域性傷害清理,但是治療無 法改善她的狀況。 電磁刺激然後可在超過5個月時間,每週7天,每天2小時 運用在她任何一手臂。她可持續接受區域性傷害清理,但 是在這段時間,她無需投予額外治療。 在2週的電磁治療之後,除了因為坐著受固定壓力的不能 治療之一1 X 1 〇公釐未癒合皮膚區域之外,疼痛與水腫會消 失。在治療的過程中,她的皮膚抗力會增加。皮膚的顏色 在早晨會是粉紅,且在坐上8到1 2小時之後,會是鮮紅色。 在4月的治療之後’潰瘍可完全復原,且皮膚會變成正常。 IV.慢性傷害 此群是包括除了慢性傷害之外的慢性傷害、週邊動脈疾 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐) 567078It will disappear eventually. After an additional 3 months of electromagnetic treatment, the supine ulcer can fully recover. The old woman patient Fan with ulcer and deep vessel embolism number 27 is sitting in the same position 8 to 12 hours a day. She suffered from deep vessel embolism causing her left ischial tuberosity to produce 60 square centimeters of pain in 18 months. One of the obese 90-year-old women with edema, hemorrhage, fragile, purple spindle, and high pressure ulcer. Pain and edema are accompanied by ulcers. During this time, the patient received medical treatment including regional injury cleanup, but treatment could not improve her condition. The electromagnetic stimulation can then be applied to any of her arms for more than 5 months, 7 days a week, 2 hours a day. She can continue to receive regional injury cleanup, but during this time she does not need to administer additional treatment. After 2 weeks of electromagnetic therapy, pain and edema will disappear, except for the unhealed 1 x 10 mm area of the skin that cannot be treated because of sitting under constant pressure. During the treatment, her skin resistance will increase. Skin color will be pink in the morning and bright red after 8 to 12 hours of sitting. After 4 months of treatment, the ulcer can fully recover and the skin will become normal. IV. Chronic injuries This group includes chronic injuries other than chronic injuries, and peripheral arterial disease. The paper size applies Chinese National Standard (CNS) A4 specifications (210 X 297 mm) 567078
發明説明 病強烈壓迫、與腹膜炎疼痛的病人。疼痛、水腫、與感 染會伴隨慢性傷害。 :感染外科傷害的高齡男性 病人編號2 8是在一長時間複雜腹部外科手術之後具有 126平方公分感染外傷之一 78高齡男子。 笔磁刺激可在3週時間,每天1小時運用在他任何一手臂 。在2週的治療之後,感染會消失,且傷害可外科縫合,因 為肉芽組織與傷害復原在此程序是最佳狀況。 :未醫治外傷的高齡男子 病人編號2 9是與抽煙、糖尿病及一般動脈硬化有關的下 肢動脈疾病之一 73歲高齡男子。慢性下肢局部貧血好幾年 。嚴重的腿局部貧血在去年很顯然,且病人接受外科再供 應脈官。然而,在操作後的3個半月,位於他左大腿及腳部 的外傷未復原,且膝外傷保持未癒合3 〇平方公分傷害。 根據本發明,電磁刺激然後可在5個月時間,每週3天, 每天2小時運用在他任何一手臂。無需對他投予額外治療。 在4週電磁治療之後,大腿及腳部傷害可復原,且傷害縮 回與上皮生長會持續治療膝部傷害,在5個月内可將傷害區 域減少至大約9 7 %。傷害可在額外1個月完全復原。 一未醫治潰瘍的中年婦女 病人編號3 0是與抽煙有關的下肢動脈疾病之一 6 5歲婦女 。外傷的結果會在造成減少活動的兩週内會發展成非常疼 痛潰瘍之一 2 · 6平方公分感染瘀傷。此傷害可抗拒生長素治 療0DISCLOSURE OF THE INVENTION Patients with severe disease and painful peritonitis. Pain, edema, and infection can be accompanied by chronic injury. : Elderly male infected with surgical injuries Patient number 2 8 is one of 78 elderly men with a 126 square cm infection trauma after a long and complicated abdominal surgery. Magnetic pen stimulation can be applied to any of his arms for 1 week per day for 3 weeks. After 2 weeks of treatment, the infection will disappear and the injury can be surgically sutured because granulation tissue and injury recovery are optimal for this procedure. : Senior man who has not been treated for trauma Patient number 2 9 is one of 73-year-old men with one of the lower extremity arterial diseases associated with smoking, diabetes, and general arteriosclerosis. Chronic lower extremity anemia for several years. Severe local anemia of the leg was apparent last year and the patient underwent surgical resupply of the pulse officer. However, three and a half months after the operation, the trauma on his left thigh and foot did not recover, and the knee trauma remained unhealed by 30 cm2. According to the invention, the electromagnetic stimulation can then be applied to any of his arms for 5 months, 3 days a week, 2 hours a day. No additional treatment is required for him. After 4 weeks of electromagnetic therapy, thigh and foot injuries can be recovered, and injury retraction and epithelial growth will continue to treat knee injuries, reducing the area of injury to approximately 97% within 5 months. Injuries can be fully recovered in an additional month. A middle-aged woman with an untreated ulcer. Patient number 30 is one of the lower extremity arterial diseases associated with smoking. 65-year-old woman. The result of the trauma can develop into one of the very painful ulcers within two weeks of the reduction in activity. An infection of 2 · 6 cm² bruises. This damage resists auxin treatment 0
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567078 A7 --~~__?!_ 五、發明説明(42 ) 根據本發明,除了 一新抗生素治療之外,電磁刺激然後 可每週5天,每天2小時運用在她任何一手臂。在兩週之後 ’感染可受控制,水腫與疼痛會明顯減少,且活動會幾乎 又得正常。先前未治癒的潰瘍底部顯現充沛的肉芽組織。 一週之後,病人會沒有徵候,並且既然開始電磁力治療, 所以潰瘍可在1個月内復原。 :感染肩傷害的中年男子 病人編號31是在兩週内,在他左邊肩發展3立方公分非常 疼痛膿瘡的一搔癢老疤痕強烈壓迫下之一 57歲男子。傷害 可使用抗生素控制,但是在兩週之後,疼痛、水腫、不活 動性、及一 3平方公分未癒合傷害仍存在。 根據本發明,電磁刺激然後可每週5天,每天2小時運用 在他任何一手臂。三週之後,疼痛、水腫、與不活動性會 消失’且傷害可減少超過7 〇 %。潰瘍可在兩週之後完全復 原。 V.避_11的局鄯貧舨心μ,扁 此群包括可復原但是低灌注心肌的病人,他們不是冠狀 動脈換新血管以供血液的候選人。 動脈硬化是造成例如下肢動脈疾病(慢性動脈腿潰瘍)、心 肌梗塞、與中風的閉塞動脈症之一般性疾病。病因因素(動 脈高血壓、高血漿膽固醇、抽菸、壓迫、糖尿病)是類似的 ,如同預防措施(去除或控制病因因素)、及某些治療(當症 狀表示血管造形術或不經外科手術)。附帶血管生長的身體 自然處置是一新的方法。治療血管生成已透過使用血管性 O:\65\65722-910515.DOC\ 4 本紙張尺度適用中國國家標準(CNS) A4规格(210X 297公釐) -45-567078 A7-~~ __?! _ 5. Explanation of the invention (42) According to the present invention, in addition to a new antibiotic treatment, electromagnetic stimulation can then be applied to any of her arms 2 days a day, 5 days a week. After two weeks, the infection can be controlled, edema and pain will be significantly reduced, and movement will be almost normal. The bottom of the previously uncured ulcer showed abundant granulation tissue. After one week, the patient will have no symptoms, and since the electromagnetic force treatment is started, the ulcer can be recovered within 1 month. : A middle-aged man infected with a shoulder injury Patient No. 31 is a 57-year-old man under the intense compression of an itching old scar that developed very painful abscesses on his left shoulder within two weeks. Injuries can be controlled with antibiotics, but after two weeks, pain, edema, inactivity, and an unhealed injury of 3 cm² remain. According to the present invention, the electromagnetic stimulation can then be applied to any of his arms 5 days a week, 2 hours a day. After three weeks, pain, edema, and inactivity will disappear 'and injuries can be reduced by more than 70%. The ulcer can be completely restored after two weeks. V. Avoiding the dysentery of _11, which is poor and flat, This group includes patients with recoverable but hypoperfused myocardium, who are not candidates for coronary artery replacement for blood supply. Arteriosclerosis is a general disease that causes, for example, lower extremity arterial disease (chronic arterial leg ulcer), cardiac muscle infarction, and occlusive arterial disease with stroke. Etiological factors (arterial hypertension, high plasma cholesterol, smoking, stress, diabetes) are similar, as are preventive measures (removal or control of etiological factors), and certain treatments (when the symptoms indicate angioplasty or without surgery) . Natural disposal of the body with blood vessel growth is a new approach. The treatment of angiogenesis has been through the use of angiogenic O: \ 65 \ 65722-910515.DOC \ 4 This paper size applies Chinese National Standard (CNS) A4 specifications (210X 297 mm) -45-
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線 567078 A7 _______B7 五、發明説明(43 ) 生長因素嘗試。酸與基本的纖維組織母細胞已在動物原型 成功測試,但是明確的臨床結果尚未在臨床實驗報告。脈 管内皮生長因素(VEGF)重組蛋白質已在具有心梗塞的病人 成功測試,這些病人不是缺乏細胞質體DnA的冠狀動脈換 新血管以增加供應及肌肉内注射的理想候選人,其表示 VEGF的165同質異形已在嚴重肢體局部貧血的病人成功測 試。 1 例31 :前隔膜急性心肌梗塞後遺症的年輕男子 病人編號3 2是前隔膜急性心肌梗塞後遺症之4 〇歲男子。 病人是透過臨床檢驗、驗血、胸部X光、心電圖、壓迫測試 、回聲心動圖、冠狀動脈血管攝影術、與心臟X射線攝影評 估。觀察的傷害係包括具擴張前部與側部次心外膜局部貧 血、及左脈管前半分岔阻滞之前隔膜心肌梗塞。在左前降 冠動脈的中間第三的9 0 %狹窄會在他起源上具第一對角線 動脈之一嚴重狹窄、慢的TIMI 2流、動脈,前部、頂部、 與隔壁動作機能缺失。噴出部份2 0 %。病人歸類為紐約心 臟病協會(NYHA)的功能等級3不能成為冠狀動脈再換新血 管供應血液。病人仍需要每日服用I sorb ide 10 mg3、Aspirin 150 mg、及在額外的4個月時間休息而未顯示任何改善。當 同前連續使用相同的醫療時,電磁力(EMFs)然後可在1個 月時間,每週3天,每天2小時運用在他任何一手臂。 在電磁力治療的1個月之後,病人改善會很快,甚至在出 現從9 0 %狹窄改變成閉塞的左降冠狀動脈傷害的不良發展 。臨床評估與壓迫測試將病人歸類為紐約心臟病協會 -46- O:\65\65722-910515 D0C\ 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐) 567078 A7 ___ B7 _ 五、發明説明(44 ) (NYtlA)的功能等級1,以取代他先前的等級3 〇透過腦室x 光攝影(ventriculograin)與回聲心電圖(echocardi〇gram)所診 斷的前部、頂部、下部、與隔膜動作機能缺失可改善運動 減退。附帶循環與hybernating心肌衰弱的收縮性可改善。 這些變化可透過他在AMI之後4個月時間接受醫療加以說 明,而且先前是暴露在電磁力。在所有的這段時間,病人 保持功能等級3 (NYHA)。最佳的說明是病人較佳臨床狀況 只在電磁力暴露之後的1個月,功能等級1 (NYHA)可提高 在除了由電磁力刺激週邊血單核白血球細胞所感應的低灌 注心肌之外可復原的血管生成與脈管生成。 範例3 2 : 3個月舊急性心肌梗塞的動脈高血壓與後遺症的 肥胖婦女 病人3 3是受3個月舊急性心肌梗塞(AMI)的動脈高血壓與 後遺症疼痛之一 5 4歲肥胖婦女。病人的評估係包括臨床檢 驗、驗血、胸部X光、心電圖、壓迫測試、回聲心電圖、冠 狀動脈血管攝影術、與心臟腦室X光攝影(ventriculography) 。傷害包括動脈高血壓、葡萄糖高血值、尿酸、三酸甘油 脂、與膽固醇。前隔膜與側次心内膜壞疽。在他起源與 8 0 %狹窄上的左降冠狀動脈閉塞的擴張前次心内膜局部貧 血、右心房擴大、冠狀血管瘤。病人每1 2小時服用 Metoprolol 50毫克、Isorbide 10毫克、每24小時服用 Pravacol 20 亳克、Norvas 2.5毫克、ASA 100毫克。3 個月 之後,動脈高血壓與驗血是在正常的限度内,但是心臟血 管徵候惡化是從功能等級2紐約心臟病協會(NYHA)到功能 O:\65\65722-910515DOC\ 4 - 47 - 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐)Line 567078 A7 _______B7 V. Explanation of the Invention (43) Growth factor attempt. Acid and basic fibroblast mother cells have been successfully tested in animal prototypes, but clear clinical results have not been reported in clinical trials. Vascular endothelial growth factor (VEGF) recombinant protein has been successfully tested in patients with myocardial infarction who are not ideal candidates for coronary arteries lacking cytoplasmic DnA for new blood vessels to increase supply and intramuscular injection. It represents 165 of VEGF Heteromorphism has been successfully tested in patients with severe local anemia. 1 Case 31: Young man with sequelae of anterior diaphragm acute myocardial infarction Patient number 32 is a 40-year-old man with sequelae of anterior diaphragm acute myocardial infarction. Patients were evaluated by clinical tests, blood tests, chest X-rays, electrocardiograms, compression tests, echocardiograms, coronary angiography, and cardiac X-ray photography. Observed injuries included local anemia with dilated anterior and lateral subepicardial membranes, and septal myocardial infarction before anterior left bifurcation block. A third 90% stenosis in the middle of the left anterior descending coronary artery will have the first diagonal in his origin. One of the arteries is severely narrowed, slow TIMI 2 flow, arteries, anterior, parietal, and adjoining motors are impaired. 20% of the sprayed part. Patients classified as functional class 3 of the New York Heart Association (NYHA) cannot be treated as coronary arteries and replaced with new blood vessels. The patient still needs to take I sorb ide 10 mg3, Aspirin 150 mg daily, and rest for an additional 4 months without showing any improvement. When the same medical treatment is continuously used as before, the electromagnetic force (EMFs) can then be applied to any of his arms for 3 months, 3 days a week, and 2 hours a day. After 1 month of electromagnetic force treatment, the patient's improvement will be very rapid, and even the adverse development of left descending coronary artery injury that changes from 90% stenosis to occlusion occurs. The clinical assessment and compression test classify the patient as New York Heart Association-46- O: \ 65 \ 65722-910515 D0C \ This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) 567078 A7 ___ B7 _ 5. Description of the invention (44) (NYtlA) functional level 1 to replace his previous level 3 〇 Anterior, top, lower, diagnosed by ventriculograin and echocardiogram, Lack of diaphragm function can improve hypokinesis. The contractility of collateral circulation and hyponating myocardial weakness can be improved. These changes can be explained by his medical treatment 4 months after the AMI and previous exposure to electromagnetic forces. At all times, the patient maintained functional level 3 (NYHA). The best explanation is that the patient's better clinical condition is only 1 month after the electromagnetic force exposure, and the functional level 1 (NYHA) can be improved in addition to the hypoperfusion myocardium induced by electromagnetic force stimulation of peripheral blood mononuclear white blood cells. Restored angiogenesis and vasculogenesis. Example 32 2: Obese women with arterial hypertension and sequelae of 3 months old acute myocardial infarction Patient 3 3 is one of arterial hypertension and sequelae pain suffered by 3 months old acute myocardial infarction (AMI) 54-year-old obese women. Patient assessments include clinical tests, blood tests, chest X-rays, electrocardiograms, compression tests, echocardiograms, coronary angiography, and ventriculography of the heart ventricle. Injuries include arterial hypertension, high glucose levels, uric acid, triglycerides, and cholesterol. Anterior diaphragm and lateral endocardial gangrene. Endometrial local anemia, right atrial enlargement, and coronary hemangioma before the expansion of the left descending coronary artery occlusion on his origin and 80% stenosis. Patients took 50 mg of Metoprolol every 12 hours, 10 mg of Isorbide, 20 mg of Pravacol every 24 hours, 2.5 mg of Norvas, and 100 mg of ASA. After 3 months, arterial hypertension and blood tests are within normal limits, but the worsening of cardiovascular signs is from functional grade 2 New York Heart Association (NYHA) to functional O: \ 65 \ 65722-910515DOC \ 4-47- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)
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•48- 等級3 (NYHA)。一壓迫測試會嘗試進行,但是會暫緩到疲 勞、高血壓與疼痛測試的開始。功能等級3 (νυηα)。 當持續她先前的治療時,電磁刺激然後可在5個月時間, 每週4天,每天2小時運用在她任何一手臂。 在電磁力治療之後的1個月,病人的評估可從功能等級3 (ΝΥΗΑ)改變成功能等級玉(ΝΥΗΑ),而且心肌衰弱的附帶 循環與收縮性可改善。這些變化會在比她先前冠狀動脈血 管瘤中所觀祭到的更嚴重傷害而發生,冠狀動脈血管瘤係 包括在它中間第三上的右冠狀動脈的額外閉塞,第一對角線 動脈的90%狹窄,及丨5 mmHg的左室心臟舒張最後壓力。 在電磁力之後的只有1個月的這些變化無法透過在AMI之 後的9個月期間接受醫療說明,而且先前已暴露在電磁力。 在所有的這段巧間,病人會從功能等級2 (NYHA)發展成功 月匕等級3 (NYHA)。病人最佳臨床狀況功能等級1 ( nyha) 的最佳說明可提咼在除了由刺激週邊血單核白血球細胞的 電磁力所感應的低灌注心肌之外可復原的血管生成與脈管 生成。• 48-Level 3 (NYHA). A stress test will attempt, but it will be postponed until the fatigue, hypertension, and pain test begins. Functional level 3 (νυηα). While continuing her previous treatment, the electromagnetic stimulation can then be applied to any of her arms for 5 months, 4 days a week, 2 hours a day. One month after the electromagnetic force treatment, the patient's assessment can be changed from functional grade 3 (NΥΗΑ) to functional grade jade (ΝΥΗΑ), and the collateral circulation and contractility of myocardial weakness can be improved. These changes can occur with more severe injuries than those observed in her previous coronary hemangioma. The coronary hemangioma line includes an additional occlusion of the right coronary artery in the third middle, and the first diagonal artery 90% stenosis and 5 mmHg left ventricular diastolic final pressure. These changes, which are only 1 month after the electromagnetic force, cannot be obtained through medical instructions during the 9 months after the AMI, and have been previously exposed to the electromagnetic force. In all of this coincidence, patients will progress from functional level 2 (NYHA) to successful moon level 3 (NYHA). The best description of the patient's best clinical condition, functional level 1 (nyha), provides restorable angiogenesis and angiogenesis in addition to hypoperfusion myocardium induced by electromagnetic forces that stimulate peripheral blood mononuclear leukocytes.
VI.足踝挫I 此群所包括的病人沒有其他潛在疼痛。此墙形術問題可 選取’以評估在一嚴重問題方面可減少疼痛與水腫的本發 明電磁力之利益,以及觀察是否可加速亦即骨折的不同類 型内傷復原處理。 幻列33 :足踝挫傷類型章伯A或B的8位病人 此範例是提出一群8位病人(病人3 4到4 1)的資訊。這些病 O:\65\65722-910515.DOC\ 4 本紙張尺度適用中國國家標準(CNS) A4規格(21〇x 297公釐)VI. Ankle Contusion I Patients included in this cohort have no other potential pain. This mural problem can be selected to evaluate the benefits of the electromagnetic force of the present invention in reducing pain and edema in a serious problem, and to observe whether the recovery of different types of internal injuries, which are fractures, can be accelerated. Phantom row 33: Ankle contusion type 8 patients of Zhang Bo A or B This example is to present information for a group of 8 patients (patients 3 4 to 4 1). These diseases O: \ 65 \ 65722-910515.DOC \ 4 This paper size applies to China National Standard (CNS) A4 specification (21 × 297 mm)
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線 567078 五、發明説明(46 ) 人是兩位婦女與6位男子,其年齡是在”到“歲,且受單 或雙足踝挫傷類型韋伯AilB的疼痛。所有的挫傷是與強烈 f痛、與水腫有關。所有的挫傷是使用内部凝固治療。挫 傷2面的壓縮可使用具或不具半管狀壓縮板的木螺釘獲得 。當指示時,三角肌韌帶的外科復原可完成。無菌的敷裹 =運用在傷害,然後一石膏骨折夾板可將腳保持在中間位 電磁刺激然後可在外科手術之後的次日開始丨〇週時間, 每週2-3天,每天2小時運用在每位病人的任何一手臂上。 腿要維持舉高,而且疼痛可每日使用Dipir〇ne 5〇〇立 而受控制。 在所有的病人中,疼痛可10減少到3_4天。水腫可從1〇 減少到5-6天,而且骨頭接合可在4週觀察到而不是6週,此 時’病人允許整個舉動。 VIL鲁椎肌肉機能声艰 此病人可如同未接受治療一疾病的神經纖維再生範例選 取。在邵份去神經支配方面,刺激一肌肉纖維的軸索與神 經末梢會退化。健全的去神經組織可透過釋放細胞漿移動 而反應,其會在去神經肌肉纖維上導致末期的Schwann細胞 ,以伸展到達一鄰近刺激肌肉纖維之神經末梢處理。然後 Schwann細胞處理會在正常的神經末梢導致一神經生長,其 可沿著去神經終板的Schwann細胞處理生長,直到去神經終 板的神經移植完成為止。在某類型脊椎肌肉萎縮的早期階 段上,當脊髓之一運動肌神經死亡時,透過電磁力的活化 O:\65\65722-910515.DOC\ 本紙張尺度適财S @家料(CNS) A4規格(加X 297公爱) •49- 567078 A7 ----- 五、發明説明(47 ) 一---— PBMCs所刺激之細胞漿發信語含可自 -可觸發鄰近健全軸索不受 產生去神經肌肉纖維的神經移植疾病所影響的事件。 範例3 4 :脊椎肌肉萎縮的年輕男孩 病人42是脊椎肌肉萎縮之-4歲男孩。正常雙胞胎懷孕盘 分娩的第二男孩,他們的父母可有利將一雙胞胎與另一相 比較。他們的記憶建議早期的發展受到延遲。他可在…固 月開始步行’但是他的步法出現異常,而且從兩歲以後, 他已不能夠跑或跳,不容易步行一或兩步,時常會容易倒 下’而且需要在他的腳上幫忙退後。在身體檢查時,所有 月几肉群的虛弱會明顯,但是尤其是在肩與骨盤腰帶。結合 舌、電肌動描記法、磁共振影像、與左四頭肌活體檢視二 這些發現可支援脊椎肌肉萎縮的診斷。在去年期間,曰常 飲食、復原治療與穩定artroses的使用無法有效改善他的狀 況。 在簽下一自願同意書之後,電磁刺激然後可在1個月時間 ,每週2天,每日2小時運用在他任何一手臂,然而,由^ 他的年齡此會不容易達成。因此,當孩子睡覺時,具 Helmholtz線圈的一新設計可用來暴露部份身體。電磁刺激 的此模態可在兩年時間,每週5天,每天_2小時運用。 透過發明家的週期性檢驗,小兒科醫師、神經學家、復 原專家、母親與教師的註解、與錄影帶可用來追蹤他的發 展。在第一個月之後,他的平衡會較佳,更有信心與他的 兄弟、姊妹、與在校同學玩耍。他開始會増加體重,而且 在4個月時,他可走路而不會跌倒,並且可開始跑與跳。在 O:\65\65722-910515 DOC\ 4 - 50 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐)Line 567078 V. Description of the invention (46) The people are two women and six men, whose age is between "to" and "one or two feet ankle contusion type Weber AilB pain. All bruises are associated with intense pain and edema. All bruises are treated using internal coagulation. Compression of the two-sided wound can be obtained with appliances or wood screws without a semi-tubular compression plate. When instructed, surgical restoration of the deltoid ligament can be completed. Sterile dressing = applied to the injury, then a plaster fracture splint can keep the foot in the middle position and electromagnetic stimulation can then be started the day after the surgery On either arm of each patient. Keep your legs elevated, and your pain can be controlled daily with Dipiron 500,000. In all patients, pain can be reduced to 10 to 3 to 4 days. Edema can be reduced from 10 to 5-6 days, and bone engagement can be observed at 4 weeks instead of 6 weeks, at which time the patient allows the entire behavior. VIL lumbar muscle function is difficult. This patient can be selected as a nerve fiber regeneration paradigm that has not been treated for a disease. In terms of denervation, the axon and nerve endings that stimulate a muscle fiber degenerate. Sound denervated tissue can respond by releasing cytoplasmic movement, which causes terminal Schwann cells on denervated muscle fibers to stretch to a nerve ending treatment adjacent to the stimulating muscle fibers. Schwann cell processing then causes a nerve growth at the normal nerve endings, which can grow along with Schwann cell processing on the denervated endplate until the nerve transplantation on the denervated endplate is completed. In the early stages of a type of spinal muscular atrophy, when one of the spinal cord motor muscles dies, it is activated by electromagnetic force O: \ 65 \ 65722-910515.DOC \ This paper is suitable for financial standards @ 家 料 (CNS) A4 Specifications (plus X 297 public love) • 49- 567078 A7 ----- V. Description of the invention (47) One ----- The cytoplasmic stimulus message stimulated by PBMCs contains self-can-trigger nearby sound axons An event affected by a neurotransplantation disease that produces denervated muscle fibers. Example 34 4: Young boy with spinal muscular atrophy Patient 42 is a -4 year old boy with spinal muscular atrophy. Normal twin pregnancy discs A second boy giving birth, whose parents may favorably compare one twin to another. Their memory suggests that early development is delayed. He can start walking at Gu Yue ', but his footwork is abnormal, and since the age of two, he is no longer able to run or jump, it is not easy to walk one or two steps, and he often falls easily. Help your feet back. During the physical examination, the weakness of the flesh group is evident in all months, but especially in the shoulder and pelvic belt. Combined with tongue, electromyography, magnetic resonance imaging, and left quadriceps biopsy, these findings support the diagnosis of spinal muscular atrophy. During the last year, regular diet, rehabilitation therapy, and the use of stable artroses were not effective in improving his condition. After signing a voluntary consent form, the electromagnetic stimulation can then be applied to any of his arms for 1 month, 2 days a week, 2 hours a day, however, it will not be easy to achieve by his age. Therefore, a new design with Helmholtz coils can be used to expose part of the body while the child is sleeping. This mode of electromagnetic stimulation can be used for two years, 5 days a week, _2 hours a day. Through periodic inspections by the inventor, pediatricians, neurologists, restoration experts, mother and teacher notes, and videotapes can be used to track his development. After the first month, he will be better balanced and more confident to play with his brothers, sisters, and schoolmates. He started to gain weight, and at 4 months, he could walk without falling, and could start running and jumping. In O: \ 65 \ 65722-910515 DOC \ 4-50 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)
裝 567078 A7567078 A7
567078 A7 B7 五、發明説明(49 ) 134 病人 230、232 電源線 136 窄床 234 變壓器 150 轉接益盒 236 橋式穩壓器 152 接點 238 電容器 154 電纜 240 電阻 157 線圈 245 窄床 159 縱長環狀通道 250 線圈 160 病人前臂 252 管壁 162 病人上臂 280 鞍狀物 200 外殼 282 身體部位 204 病人身體部位 288 電纜 214 定時器 290 控制單元 216 控制機制 292 定時器 218 電子面板 294 控制機制 224 赫姆霍茲線圈 298 線圈 O:\65\65722-910515 DOC\ 5 - 52 - 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐)567078 A7 B7 V. Description of the invention (49) 134 Patient 230, 232 Power cord 136 Narrow bed 234 Transformer 150 Transfer box 236 Bridge regulator 152 Contact 238 Capacitor 154 Cable 240 Resistance 157 Coil 245 Narrow bed 159 Length Loop channel 250 Coil 160 Patient forearm 252 Tube wall 162 Patient upper arm 280 Saddle 200 Housing 282 Body part 204 Patient body part 288 Cable 214 Timer 290 Control unit 216 Control mechanism 292 Timer 218 Electronic panel 294 Control mechanism 224 Hz Holtz Coil 298 Coil O: \ 65 \ 65722-910515 DOC \ 5-52-This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)
Claims (1)
Applications Claiming Priority (1)
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US15118599P | 1999-08-27 | 1999-08-27 |
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TW567078B true TW567078B (en) | 2003-12-21 |
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ID=22537671
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TW89117304A TW567078B (en) | 1999-08-27 | 2000-08-22 | Electromagnetic apparatus of treatment of lesions associated with inadequate blood perfusion, partial denervation, tissue loss, pain, edema, inflammation and infection |
Country Status (4)
Country | Link |
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AU (1) | AU7679300A (en) |
CA (1) | CA2389134C (en) |
TW (1) | TW567078B (en) |
WO (1) | WO2001015770A2 (en) |
Families Citing this family (12)
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US6733435B2 (en) | 2002-03-08 | 2004-05-11 | Canedo Luis | Electromagnetic method of treatment of lesions associated with inadequate blood perfusion, partial denervation, tissue loss, pain, edema, inflammation and infection |
WO2003080179A1 (en) * | 2002-03-27 | 2003-10-02 | Nippon Sigmax Co., Ltd. | Cytokine controlling device, treating device and treating method |
DE60216732T2 (en) * | 2002-05-29 | 2007-11-15 | Dr. Richard Markoll | Device for treating a human body part by means of an electromagnetic field |
GR1004411B (en) | 2002-07-25 | 2004-01-07 | Electronic device for strengthening the immune system with the use of magnetic fields based on the characteristics of a multi channel biomagnemometer | |
US20070078292A1 (en) * | 2005-10-05 | 2007-04-05 | Electromagnetic Resources, Inc. | Electromagnetic fields for systemic effect in therapy |
WO2011078645A2 (en) * | 2009-12-21 | 2011-06-30 | Alandra Medical S.A.P.I. De C.V. | Electromagnetic stimulation equipment for systemically treating chronic arm wounds, activating angiogenesis and increasing vascular permeability |
WO2011078644A2 (en) * | 2009-12-21 | 2011-06-30 | Alandra Medical S.A.P.I. De C.V. | Electromagnetic stimulation equipment for systemically treating chronic thoracic wounds, activating angiogenesis and increasing vascular permeability |
US10076384B2 (en) | 2013-03-08 | 2018-09-18 | Symple Surgical, Inc. | Balloon catheter apparatus with microwave emitter |
US10631966B2 (en) * | 2015-08-12 | 2020-04-28 | Innoventions Ltd | System for sphincteric and other tissue regeneration |
EP3579920A1 (en) | 2017-02-07 | 2019-12-18 | Santi Tofani | Apparatus for treating pathological cells |
EP3744392A4 (en) * | 2018-01-24 | 2021-09-22 | Hefei Institutes of Physical Science, Chinese Academy of Sciences | Method for cartilage regeneration, magnetic pulse device, and coil applied to magnetic pulse device |
US10967194B2 (en) | 2018-05-02 | 2021-04-06 | Shealy-Sorin Wellness, Llc | Pulsed electromagnetic field device and methods of use |
Family Cites Families (4)
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CA2021506A1 (en) * | 1989-08-17 | 1991-02-18 | Abraham R. Liboff | Electromagnetic treatment therapy for stroke victims |
US5131904A (en) * | 1990-05-04 | 1992-07-21 | Richard Markoll | Treatment of arthritis with magnetic field therapy and apparatus therefor |
US5314401A (en) * | 1991-03-29 | 1994-05-24 | Amei Technologies Inc. | Conformable PEMF transducer |
US5752911A (en) * | 1995-04-27 | 1998-05-19 | Canedo; Luis E. | Electromagnetic method of treatment of epilepsy and apparatus |
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2000
- 2000-08-22 AU AU76793/00A patent/AU7679300A/en not_active Abandoned
- 2000-08-22 TW TW89117304A patent/TW567078B/en not_active IP Right Cessation
- 2000-08-22 CA CA002389134A patent/CA2389134C/en not_active Expired - Lifetime
- 2000-08-22 WO PCT/IB2000/001480 patent/WO2001015770A2/en active Application Filing
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CA2389134A1 (en) | 2001-03-08 |
CA2389134C (en) | 2006-05-16 |
AU7679300A (en) | 2001-03-26 |
WO2001015770A2 (en) | 2001-03-08 |
WO2001015770A3 (en) | 2001-09-27 |
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