TW567078B - Electromagnetic apparatus of treatment of lesions associated with inadequate blood perfusion, partial denervation, tissue loss, pain, edema, inflammation and infection - Google Patents

Abstract

An apparatus of treating a body lesion associated with inadequate blood perfusion, partial denervation, tissue loss, pain, edema, and/or infection, comprising means for applying to a subject afflicted with a lesion, externally and non-invasively at a site removed from the lesion, analgesic, angiogenic, vasculogenic, nerve growth, osteogenic, anti-edema, anti-inflammation and/or wound repair effective electromagnetic fields (EMFs) comprising frequencies of a few Hertz to less than about 300 Hz and static magnetic field components from a few microTesIa to a maximum intensity of about 0.3 to about 0.8 mT used alone or in combination with a homogeneous static magnetic field of about 40 to about 80 mT or about 400 to about 800 gauss.

Description

567078 A7 B7 V. Description of the invention (1) Background of the invention The invention generally relates to devices for the treatment of skin injuries and internal injuries that can be restored, for example, in addition to hypoperfusion myocardium. More specifically, the present invention relates to the treatment of inadequate blood perfusion, tissue loss, partial denervation, injuries, fractures, lame feet, by using a time-varying electromagnetic field alone or simultaneously using a static magnetic field on a particular body. And / or a body device for ulcer pain. Background Description Local application of electromagnetic fields (EMFs) has been shown to increase skin and nerve fiber regeneration, glia cell formation and tension during skin injury recovery. Electromagnetic forces have also been shown to lead to fibroblast mother cells and promote angiogenic reproduction and the provision of glial growth. In addition, locally applied electromagnetic forces have long been thought to promote the automatic recovery of soft tissues. Chronic venous leg ulcers and compression ulcers can be treated through a variety of therapeutic applications, including growth factors that can be directly applied to the wound site, radon specific gravity, local infrared radiation, electromagnetic force, ultraviolet and low energy lasers, and ultrasound Local application. However, the health care policy and research institute of the National Health Service Department of China recommended the topical application of electromagnetic force as the only adjuvant treatment that can be used to support signs of edge ulcer treatment. Although topical application of electromagnetic force can be used to treat chronic venous leg ulcers, nerve fiber regeneration: fractures, and animal models that protect against the sequelae of local anemia due to irritation, all attempts can be made using electromagnetic force therapy at a point away from the site of pain The phase has failed. 、 When getting the condition improvement day temple, do not apply magnetic force to the injured part to treat O: \ 65 \ 65722-910515 〇〇〇 \ -4-

Harm to JOLL — I help, and hereby I feel that even in the whole recovery injury # will have a larger feeling that will not stain the Shao bit to some extent, or just avoid the patient's day ’. In terms of free medical training for treatment diagnosis and prescription and the results obtained by special applications, this treatment can be administered to people who need advanced technology and reduce the cost of treatment. It is clear that it is necessary to accelerate and promote the recovery of a bodily injury. Methods, especially resistance to other more traditional treatments, are inconvenient for a skilled person in the outpatient body, and give Patient T is inconvenient. This treatment is clearly treatable and cost effective. SUMMARY OF THE INVENTION The present invention relates to a device for treating injuries, burns, skin ulcers, and recoverable devices other than low irrigated muscles, which includes the actual application of injuries, burns, and cases where bones or ulcers are restored. Special external and non-invasive ultra-low frequency electromagnetic fields (EMFs) are applied to the body from which the injury is to be removed in order to improve angiogenesis and angiogenesis' and improve the effectiveness of other subsequent treatments. Appropriate electromagnetic forces include a time-varying electromagnetic field element generated at a frequency from a few hertz (more than 1) to less than about 300 hertz and a static magnetic field element of about several micro-magnetic flux densities, such as' about 2-5 μT, about 20 μT to Approximately 100 μT, approximately 0.3 mT, approximately 0.8 mT. These electromagnetic forces can be used alone or in combination with a coherent static magnetic field of about 40, about 50 to about 70, about 80 mT (or about 400, about 500 to about 700, about 800 Gauss). Although the measurement frequency inside the coil is about 0.3 to about 0.8 μT in some cases, the intensity of the electromagnetic force can be reduced to the surrounding magnetic field in the area of the skin close to but not inside the coil. O: \ 65 \ 65722-910515 D〇C \ 4 -5-: The clear method is particularly suitable for skin injuries such as burns, such as if, partial denervation and ulcers, especially for example veins and dynamic compression materials , Non-secreted injury, infection injury, pain and inflammation foot1 ... special injury, for example, in addition to low irrigation m and other recoverable non-hard quasi-injection area pain in the body has effective treatment, these can be combined such as arteriosclerosis, varicose veins, diabetes * "#Fire is called Diabetes, diabetes, blood pressure, rheumatism, fire, trauma and other reasons ^ see. Some injuries may be resisted or irreversible… or the traditional method of treatment, but the current stage of treatment administration makes them highly responsive to previously ineffective treatments. The method can be administered for a short period of time and the treatment body is repeatedly treated for a period of time to reduce pain, swelling, inflammation and infection, gradually increase angiogenesis, angiogenesis, nerve fiber regeneration, #plasmid junction, & Reconstruct the body's immune anti-inflammatory response and injury recovery treatment. , ^ This treatment method can significantly reduce the recovery time of previously highly resistant other traditional medical bodies. κ The present invention will be described in detail through various figures and several examples described later. BRIEF DESCRIPTION OF THE DRAWINGS There are two preferred methods for exposing a body part to the magnetic field of the present invention. The first method is to design using one of a combination of a time-varying magnetic field and a static magnetic field. Two different embodiments of the device of the invention of the first design can be provided for this purpose. A first specific embodiment of such a device design is described in FIGS. 1 to 7. Figure 1 depicts a simplified perspective view of a part of the device of the present invention as seen from the outside O: \ 65 \ 65722-910515 DOC \ 4 -6- 567078 A7 B7 V. Description of the invention (4) Figure 2 is depicted in Figure 1 Part of the device shown is a perspective and cross-sectional view. Fig. 3 is a diagram showing a magnetic flux generated by combining a variable and static magnetic field generated according to the present invention. Fig. 4 is a diagram showing a waveform generated by supplying a coil current through the circuits of all embodiments of the device of the present invention. Fig. 5 is a diagram showing the frequency distribution of electromagnetic signals generated by all the specific embodiments of the device of the present invention. Figure 6 is a simplified top view of an arm extending inside the spiral coil and the permanent magnet as shown in Figure 2. FIG. 7 is a power supply circuit diagram of one of the solenoids for exciting the device of the present invention. A second specific embodiment of the first design of the device of the present invention is shown in Figs. 8 to 10. This specific embodiment is an enlarged view of the first specific embodiment shown in Figs. Figure 8 is a perspective view depicting a device of the present invention that exposes the body to electromagnetic forces. FIG. 9 is a side view of the device shown in FIG. 8. FIG. A second design of the device of the present invention only exposes the body part to a time-varying magnetic field. Five different specific embodiments of the device of the invention can be used as examples for this purpose. The first of the five specific embodiments is shown in FIGS. 10 to 13. In this embodiment, the permanent magnets of the device described above are removable, while the other components remain unchanged. Fig. 10 is a simplified perspective view illustrating a part of the apparatus of the present invention as seen from the outside. FIG. 11 is a perspective and cross-sectional view of a portion of the device shown in FIG. 10. O: \ 65 \ 65722-910515.DOC \ 4 This paper size applies to China National Standard (CNS) Α4 size (210 X 297 mm) 567078 A7

Fig. 12 is a diagram showing an electromagnetic flux generated by a time-varying magnetic field according to the present invention. FIG. 13 is a simplified top view of an arm extending between the magnetic coils of the coil shown in FIG. 11. FIG. The second of the five specific embodiments is shown in Figs. This is a simplified diagram of the specific embodiment shown in FIGS. 10 to 13. Figure 14 depicts a simplified perspective view of one of the devices of the invention as seen from the outside. FIG. 15 is a perspective and sectional view of a portion of the device shown in FIG. 14. Fig. 16 is a simplified top view of an arm extending between the magnetic coils of the coil shown in Fig. 15, for example. A third one of the five specific embodiments is shown in Figs. 17 and 18, and is an enlarged view of the specific embodiments shown in Figs. 10 to 13. Figure 17 is a side view of a device of the present invention depicting a body exposed to electromagnetic forces. FIG. 18 depicts a perspective view of the device shown in FIG. In a fourth of the five specific embodiments of the device of the present invention, the time-varying magnetic field of the present invention can be generated through two Hemholtz coils. Figures 19 to 23 describe this embodiment. Fig. 19 is a simplified perspective view illustrating the device of the present invention as viewed from the outside. FIG. 20 is a perspective and sectional view of the device shown in FIG. 19. Fig. 21 shows an electromagnetic view pattern generated by a time-varying magnetic field according to the present invention. Fig. 22 shows a simplified perspective view extending between the magnetic coils of the device shown in Fig. 19. Figure 2 3 describes the O: \ 65 \ 65722-910515.DOC \ 4 extending between the magnetic coils of the device shown in Figure 2 2 This paper size applies to China National Standard (CNS) A4 (210 X 297) Mm) -8-Staple

Line 567078 A7 ____B7 V. Description of the invention (6) A simplified perspective view of the body, in which the device is placed upside down and fixed on the bed. Figure 24 is a diagram of a power supply circuit for a magnetic coil used to excite the device of the present invention. A fifth specific embodiment of the device is shown in Figs. In this embodiment, the time-varying magnetic field of the present invention is generated by a coil disposed in a recess. Figures 25 and 5 illustrate a simplified perspective view of an apparatus of the invention as seen from the outside. FIG. 26 is a perspective and sectional view of a portion of the device shown in FIG. 25. FIG. Fig. 27 is a diagram showing an electromagnetic flux generated by a time-varying magnetic field according to the present invention. Fig. 28 is a simplified perspective view of an animal limb extending between the magnetic coils of the device coil shown in Fig. 26, for example. Figure 29 shows the influence of magnetic fields on the diffusion of peripheral blood mononuclear leukocytes (PBMCs) obtained from normal objects. PMBCs with non-electromagnetic force affecting cell division can be used at 00%. Combining the effects of static and time-varying magnetic fields can result in an 11.1% increase in the diffusion of PBMCs (through gtudent, D, test ρ <〇〇〇〇ι). Only the static magnetic field has no statistically significant effect on the diffusion of PBMCs. The previous and other objects and features of the present invention will become more apparent from the following detailed description of the present invention and the accompanying drawings. Detailed description of the embodiments There are not significant effective treatments for various effects. In addition, it needs to be directly administered to O: \ 65 \ 65722-910515.DOC \ 4 This paper is suitable for financial standards 8 S family standards (CNS) A4 specifications (21G χ 297 public love) 567078 A7 B7 V. Description of the invention (7) ----- In the area of injury. This will make patients sick, not easy to implement, and obviously inconvenient. Costs The inventors have surprisingly found that when chronic skin injuries or internal injuries such as fractures A body that is partially denervated or that can be restored in addition to hypoperfusion myocardium. When an electromagnetic field (EMFs) is applied to a part of the body according to the present invention, the injury will show stimulation of inflammatory response and injury recovery; As a result, the injury hall will be significantly and rapidly reduced, and in many cases, it can be quickly restored and / or removed completely. This situation can even be used to resist other commonly effective treatments. According to the present invention, in addition to low perfusion myocardium Externally recoverable, electromagnetic; can be applied to a part of the body to produce better clinical improvement as shown by increasing collateral circulation and myocardial contraction. The benefits obtained by the inventors can be achieved by, for example, the hand =, hand, leg, or foot body On limbs, or even exposing the entire body to special electromagnetic fields (EMFs) with special fixed and variable elements. The problem with clinical experience is that some bodies that are internally and externally injured can be administered to them in a matter of seconds. Drugs and other effective therapies. In addition, other injuries, internal injuries, hypoperfusion tissues, burns, and ulcers will not respond to these treatments. The inventor of the present invention surprised A to discover that when the body is exposed to the outside according to the present invention When non-invasive electromagnetic fields (EMFs), they become responsive to previously ineffective treatments, such as known injury treatment drugs and other treatments. Many of the bodies that benefit from treatment include acute myocardial infarction, venous or arterial leg ulceration, burns, compression ulcers, surgical infection injuries, fractures, tissue loss, partial denervation, insufficient blood perfusion, and painful and inflamed soft tissue. Medical record 'which can resist or not respond to the available treatments of surgery, medicine, or more traditional methods O: \ 65 \ 65722-910515 DOC \ 4 -10-

567078 A7

The present invention can use special electricity to remove the wound ~ U "field_Fs), which can be beneficially applied. Magnetic force: 'Shao bit. Although other electromagnetic force actions in exposing body tissues have not been eliminated, but this electromagnetic force Stimulation-Body Immune 'The ideal target is the body's stimulated and memorized peripheral blood mononuclear white cells: globular cells (_). Activation of one of the body's immune systems will cause a "natural reaction" to use the necessary cells and cytoplasm , Vascularity, osteogenesis and growth, 1 growth factors, hormones and other immune modulators to provide immune nerves: secretory glands regulate the injury part 纟 and other ㈣, which will bring related examples = injury injury, veins and arterial legs Ulcers, compression ulcers, chronic infections, such as internal or external areas with insufficient blood perfusion in addition to recoverable hypoperfusion myocardium, muscle loss, fractures, partial denervation, pain and inflammation of soft tissues, and other skin injuries Effective treatment. The electromagnetic fields (EMFs) of the present invention include time-varying magnetic fields, that is, alternating currents that oscillate at a specified frequency. In a specific embodiment of the present invention, the AC power range is a frequency from a few hertz (over 1 cycle per second), about 10 Hz, about 50 Hz to 100 Hz, about 200 Hz, and about 300 Hz. Produced by a spiral coil with a maximum intensity near 120 Hz and its harmonics. See Figure 5 for this patient. These time-varying magnetic fields have small static magnetic fields from several micro-magnetic fluxes, such as about 2-5 μT, about 10 μT to about 100 μT, about 0.3, about 0.8 mT. A strong static magnetic field with a strength of about 40, about 50 to about 60 μT, about 70 μτ, and about 80 mT (400 to 800 Gauss) is near the atoms in the permanent magnet of the present invention placed near the spiral coil. 0 O: \ 65 \ 65722-910515 DOC \ 4 This paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X 297 public binding line-12- 567078) V. Description of the invention (may It can be achieved directly or through immune cells or other exposed tissues or through the products of fine moons. _______________ The recovery of wounded tissues, and the auto-recovery or stimulants increase angiogenesis, angiogenesis, and damage recovery. Physical Immunity_Solution Features Reticulated tissue sleep, *,, ', reduce pain, edema, and infection. When a hand or a part of the body is exposed to the ENTs of the present invention, such as skin muscles, blood and lymph Tubes, red blood cells, bones, nerves, and extra-maternal PBMCs and other tissues are under the influence of the EMFs of the present invention. ^ Some conditions' Tissues exposed at the same time can be stimulated in order to reduce injury, hypoperfusion tissue, partial denervation Area , Fracture recovery, or immune neuroendocrine glands that contribute to the regulation of injury recovery, secrete products at a distance. Therefore, the present invention relates to a method for treating a physical injury. These physical injuries are related to pain, edema, inflammation, fracture, Partial denervation and, or infection, wound healing, and / or hypoperfusion tissue that can be restored in addition to hypoperfusion myocardium, insufficient blood perfusion at the injury site, and / or a damaging immune-mediated inflammatory response Related to injury recovery treatment, which includes application to an injured pain, external and non-invasive and a body where the injury is to be removed, analgesics, vascularity, angiogenesis, nerve fiber growth, anti-edema, and injury recovery effective Electromagnetic fields (EMFs) contain several hertz frequencies, ideally about 0.1 Hz, about 1 Hz, about 5 Hz, about 10 Hz, about 20 Hz, about 60 Hz, about 80 Hz, about 1000 Hz , About 120 hertz to less than about 180 hertz, about 240 hertz, about 300 hertz; and a static magnetic field element that has a few micro-fluxes Minimum intensity, such as about 2-4 μT, about 10 μT, about 50 μT, about 100 μT to about 0.3, about 0.4, about 0.5, about 0.6, about 〇 7. Big O: \ 65 \ 65722-910515 DOC \ This paper size is applicable to China National Standard (CNS) A4 (21〇x 297 mm) Gutter 567078 A7 ___B7 5. Description of the invention (1〇) about 0.8 mT. These electromagnetic forces can be used alone or with about 40, about 50 to about 70, about 80 mT (or about 400, about 450, about 500, about 550 Gauss to about 600, about 650, about 700, about 800 Gauss) combined with a static magnetic field. In the method of the present invention, electromagnetic force can be applied to a body limb, an arm or a leg, and in some cases, it can be applied to a hand or a foot, other parts of the body, or the entire body. The method can be performed at any time and includes administration of about 5 minutes to about 7 hours each time. In a preferred embodiment, electromagnetic field (EMFs) administration can be performed for a period of time to expose the entire blood volume of the body to electromagnetic forces at least once. This procedure ensures that the entire blood volume is exposed to electromagnetic forces and induction effects to all cells present in the bloodstream, especially stimulated and memorized peripheral blood mononuclear leukocytes and their earlier cells. Although an application of electromagnetic fields (EMFs) is sufficient in many cases, the application can be repeated as many times as necessary. Ideally once a week, twice a week, 3, 4, 5, 6, and 7 times a week, and up to about i, 2, 3, 4, 5, 6, 7, and 8 weeks, and even months and months Years. In addition, the method also includes the repeated application of electromagnetic forces. The method of the present invention may be beneficial in the treatment of diseases and conditions caused by-and / or caused by, physical injury. In all cases, the application of a sufficient amount of electromagnetic fields (EMFs) can be implemented until the injury is mitigated and / or fully recovered. Injuries that can be treated using current technology are chronic injuries, partial denervation, loss of muscle tissue, fractures, burns, injuries caused by insufficient blood perfusion, such as in addition to the lower canal, steeper, lower precision, and cardiac muscle Recoverable, unsuccessful surgical results, and other differences * Xingde ^ ^ Venous, arterial, and vascular problems O: \ 65 \ 65722-910515.DOC \ 4 -13-

567078 A7 B7 V. Description of the invention (") G- 2 arterial and venous old ulcers. Examples of different injuries and their descriptions, 'Various other treatments available and to some extent or not successfully overcome The diseases and conditions will be provided below. Chronic venous plaques will be tested on 7 veins and legs—! · In the first stage, the venous leg will be cleared and the cancer will usually be caused by venous insufficiency caused by increased walking pressure. Valve disability. This effect can be extended to most cases of small blood vessels, small veins, and hair capillaries. Pressure will cause increased interendothelial space 'and then increase the invasion of small solute, macromolecules and blood cells. This can be seen as the leakage of small and macromolecules of the endothelial tissue and blood cells, and sent into the space between the tissues. It can be seen that the simultaneous occurrence of lymphovascular disease and reduced lymphatic drainage, which weakens clinical edema. Slow Blood flow is formed, and the increased adhesion of white blood cells and platelets in the endothelial cell layer results in the formation of microfibrinase, which reduces the number of capillaries. These changes eventually lead to Gangrene replaced by tissues, gangrene makes the skin of the boot area vulnerable to ulcers. I. 1 Venous leg ulcer treatment Most vascular changes are traditionally treated by lifting the leg, compressing the outer part, and / or surgical procedures Microvascular changes can be treated with systematic drugs such as venotonic drugs, the most commonly indicated drugs, platelet aggregation inhibitors, white blood cell activity inhibitors, and fibrinolytic and thrombolytic agents. However, 'at present there is no convincing Evidence exists to suggest these agents that can be used for the treatment of venous leg ulcers. II. Chronic Arterial Leg Holocaust O: \ 65 \ 65722-910515 D〇C \ 4 -14-

567078 A7 B7 V. Description of the invention (12) In most cases, the lower limb arteriosclerosis is the first cause of arterial leg ulcers, and it will cause the arterial flow to significantly worsen and narrow and the peripheral circulating blood flow to gradually decrease. As the disease worsens, the arteriosclerotic damage usually expands. Insufficient nutritional support for peripheral microvascular circulation occurs when blood flow is completely diminished and nutritional capillary perfusion pressure is irregular. In addition, leukocyte adhesion, blood platelet agglutination, hemorheology, and increase in arteriolar microfibrinase can be seen. These help to further reduce the number of capillaries. Arterial changes are clinically described as temporary pain, nourishing skin changes, and ulcers. In addition, these injuries are often infected. II. 1 Treatment of chronic arterial leg ulcers The emergence of invasive treatments includes vascular angioplasty, vascular restoration and resection. Most medications focus on reduced pain and reduced infections. Currently, severe leg anemia is not recommended throughout Europe for any additional medical treatment of arterial leg ulcers. Iπ · 1 pressure ulcers (Wollo Qingwen, most pressure ulcers are common, and inactivity is complicated. In many cases 2, they will resist medical treatment. This resistance will be obvious with nutritional disorders, infection, and advanced age Increased. These ulcers usually increase the risk of patient death. ^ Acute care hospitals and nursing homes need to maintain a long nursing door. For example, in the case of spinal cord injury patients, this problem will have 7 _ 8 0 /. ^ Compression, friction, shearing force, and clear air will be involved in the onset of skin collapse, but the treatment will also be worsened by moderate infection. 111,1 (Lying posture ulcer) The most common treatment is to treat the patient Reset open # to avoid any special characteristics of the body: \ 65 \ 65722-91〇515d〇c \ 4 paper size _ A4 # .i () ^ 297 mm) 567078 A7 _____B7 V. Description of the invention (13) Excessive area oppression. In addition, the basic treatment procedure commonly used in these patients is general injury care, and treatment is to control the underlying disease. Patients also recommend moderate nutritional habits, and it is recommended to obtain ascorbic acid, zinc, and non-metallic supplements. IV. Chronic Injury In most cases of chronic injury, inadequate blood supply, edema, and tissue insufficiency, cell death and infection enhanced by aging and continued stress can be found in cells containing growth factors, hormones, etc., and in The immune neuroendocrine gland reduces peptide characteristics among the effects of communicating with reticular tissue. Due to the lack of a normal immune-mediated inflammatory response and / or recovery process, recovery is weakened. The treatments currently available are only partially effective, and long-term predictions are poor for these patients. The current state emphasizes the need for new methods to treat chronic injuries, such as the characteristics of cells and cytoplasm required for activated injury recovery, nerve fiber growth, angiogenesis, and angiogenesis. V. Myocardial infarction Arteriosclerosis is a general disease that causes, for example, arterial disease of the lower limbs (chronic arterial leg ulcers), myocardial infarction, and occlusive arterial disease with pulse. Etiological factors (arterial hypertension, high plasma cholesterol, smoking, stress, diabetes) are similar to these diseases. The majority of deaths in patients with myocardial infarction are caused by arrhythmia, infarct dilatation, and post-infarction changes. V. 1 Prevention of myocardial infarction. "Shi Zhixi focuses on removing or controlling the etiology factors. The mortality rate in the early stage of myocardial infarction can be reduced. After the use of blocking agents, hemolysis and blood tests, urethral catheters can be supplied to the vasculature. Or non-expansive vascular angioplasty, non-surgical hand O: \ 65 \ 65722-910515 D〇C \ 4 · 16- This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) for surgery and vascular tightening Transforming enzyme inhibitors, reached aspirin. For patients who are recoverable outside of low-perfusion myocardium and will not become coronary resupply vessels, vascular growth factors are still in clinical research VI. Fracture The three overlapping phases of fracture and fracture recovery have been described: a) an inflammatory phase similar to a skin injury inflammatory phase; b) a repair phase, in which osteoblasts diffuse and bone underwear tissue is the skin In the middle of sclerosis formation, and c) the transformation stage, in which fractured skin sclerosis and bones are transformed to voluntarily agree to the normal shape and strength. In the three stages of fracture, restoration of PBMCs and cytoplasm play an intermediate role. Objective The treatment system includes surgery, fixation, and local application of electromagnetic fields to bone formation. Νπ · Spinal muscle twilight in childhood and childhood Spinal muscular atrophy is one of the early onset and inherited progressive degenerative diseases of spinal motor muscle neurons. Although clinically similar to muscular dystrophy, in these patients, muscle atrophy is derived from nerve fiber degeneration. Some children can develop normally for several months before weakness becomes apparent. The drive, pelvis, and shoulder and waist muscle groups can be unevenly affected Disease will progress with stable alpha, and most patients have short life spans. Some can live for years and even work and maintain. At this stage, there is no help for the treatment of these diseases / sigma therapy a limited rehabilitation therapy and orthopedics. New ways to regenerate nerve fibers 疋 Therapeutic factors for neuropathy, Schwann cell treatment, and local application of current or electromagnetic fields to induce currents, although these treatments cannot be used to treat spinal muscle atrophy. O: \ 65 \ 65722-910515 DOCN 4 -17- 567078 V. Description of the invention (15 The types of diseases and conditions related to injury are for example Ministry Denervation: two groups: loss, burns, fractures, local anemia and traumatic injuries, k injuries and ulcers. Through a more specific example, the following diseases 4; can be restored by, for example, except hypoperfusion myocardium, etc .: No = Fluid injection, tissue gangrene, pain, edema, and infection; and T; Extending inactive fat spleen, secretive ^, so μ, bad betrayal, chronic injury and worsening scald == Shao and external chronic injury; by trauma, injury and surgery = ?: the situation 'e.g. Nerves and nerves are limited to recoverable in addition to low perfusion myocardium, such as ulcers caused by static = supine rectal cancer, high pressure cancer, moderate foot depression, spinal muscular atrophy, etc .; t !: Fate and cancer of the lower limbs are located in the body lion, ° Cancer of the lower limbs is individual or whole; Use this method: Buco :! Non-surgical. Usually non-trauma is in addition to hypoperfusion myocardial: In addition, b-recovery, iliac vein and arterial leg ulcers, compression trauma is related to injury caused by surgery, broken deep implants, or a surgical drainage]. Insufficient caused by ^ more thanks i 'Ύ U. Go to the standard / Wang's typical diseases related to :: ΓμΓ sclerosis, venous insufficiency, deep blood vessel plugging and === inflammation, diabetes, rheumatoid arthritis, And long time. Sitting seated or lying down O: \ 65 \ 65722-910515 DOC \ -18- 567078 A7 B7 V. Description of the invention (16) This method can also improve the application of a method related to pain, edema, and / or inflammation. One of the healing effects of physical injury. In many cases, a patient who was previously ineffectively treated can respond to the same treatment in a series of electromagnetic fields (EMFs). In this way, this method can improve the body's response to the treatment, and then, it can reduce the physical injury and pain, edema, and / or inflammation accompanying it. This method is particularly practical, in which a body becomes resistant to drugs used to treat a disease or condition, and the application of electromagnetic fields (EMFs) can voluntarily agree with the ability of drugs or surgical treatment to improve physical health and mobility. Examples of this treatment are angioplasty, surgery, saphenous vein resection, skin grafting, injury termination, sutures, bandages, antihypertensive treatment, pharmaceutical surgery, nursing care and body injury cleaning. Examples of pharmaceutical ingredients that are typically administered to patients suffering from the above mentioned pain are analgesics, anti-inflammatory agents, antibiotics, flavinoids, tissue plasmin catalysts, aspirin, prostacyclin agents, prostanoids, venotonic drugs, fibrin

Thread dissolving and thrombolytic agents, daily diet, etc. These medicaments may also be administered with or subsequently to electromagnetic force according to the present invention. The preferred embodiments of the present invention will now be described with reference to the drawings to facilitate the understanding of the present invention. The treatment can be applied to the device of the present invention as shown in Figs. _2, 8_9, 10_n, 17-18, 19-20, 22-23, and 25-20. Various specific embodiments of the device are designed to be derived from patient observations of similar problems in the time-varying magnetic field of the present invention or in conjunction with static magnetic fields. Figures 1-9 describe the use of a time-varying magnetic field in conjunction with a static magnetic field. Figures 8 and 9 depict an enlarged embodiment of the invention having a sufficiently large interior chamber to expose, for example, a large portion of the human body.

567078 A7 B7

In a particularly preferred embodiment of the device that has been used multiple times successfully, the permanent magnet is removable, but the time-varying electromagnetic field is maintained. Refer to Figures 10 to 16. Another embodiment may provide a device similar to that previously described, but with a large enough internal chamber to expose a portion of the human body, such as from the upper limit of the aorta to the lower limit of the liver and spleen to the magnetic field inside the room. Refer to Figures 17 and 18. In this way, time-varying magnetic fields with the same characteristics can be applied to patients' large blood and lymphatic vessels: the aorta, vana vena cava and chest tube, and large blood and lymphatic grooves: heart, lung, liver, spleen, and external spinal nerve center. This treatment involves exposing a large number of peripheral blood mononuclear white blood cells to the electromagnetic field and reducing the treatment time. These specific embodiments of the device are designed to provide a comfortable position for the patient during the magnetic field exposure. In still another embodiment of the device of the present invention, the characteristics of the time-varying magnetic field are the same as those of the above device, but can be generated by, for example, two parallel coils, that is, Hemholtz coils. These coils produce a homogeneous electromagnetic field in the center between them. This embodiment can expose a human body part lying on a bed to a time-varying magnetic field. Refer to Figure 19-22. However, another specific embodiment may provide a slight variation of the above device, but similar equipment is inverted and fixed next to a narrow bed made of non-magnetic material. The direction of the magnetic flux generated by the coil will be perpendicular to the axis of the human body. The controls can be easily set by the bed, as shown in Figure 2-3. Another specific embodiment of the device is a coil disposed in a saddle, so that the magnetic field can travel perpendicular to the limb. This device is built for veterinary applications and has been successfully used to treat a horse's irritated joints and skin injuries. However, it can also be used in humans. Refer to Figures 25 to 28. O: \ 65 \ 65722-910515 D〇C \ 4 This paper size is applicable to China National Standard (CNS) A4 specification (210 x 297 mm)

Binding

V. Description of the invention (18 is still another and exciting of the present invention, and * can be generated in two different ways. "The electromagnetic field of the present invention can be borrowed at the same or similar frequency of the present invention. By electric and magnetic energy (that is, focusing on any (transmission = two antennas). Another method is to adjust the electromagnetic field of high intensity and frequency too private, such as the electromagnetic field generated by a Tesla coil: and using The frequency is the same or similar. In the latter case, the magnetic field passing through the empty t can reach the lying or sitting patient, but not the device. Μ That is, referring to FIGS. The general shape of a rectangular or one-piece box 101, which can be made of wood, plastic, or other non-magnetic materials' to avoid interference with an electromagnetic field application of the patient's body part. The front or panel 103 of the device usually has a circular opening 104 Its expansion is like an elongated circular channel 105 in Yi 101. Channel 105 can usually be expanded horizontally in Ying 101, and when not in use, it can be closed, and on the back wall or panel 111 Has a terminal 109. Ideal Installed on the panel 103 is a timer 113 and a control mechanism 115, which are connected to an electronic panel 1Π to change and control the strength and duration of the magnetic field. As shown in Figure 6, in the channel The configuration on each inner longitudinal end of the 105 is a spiral coil 119 for supplying a time-varying magnetic field. In addition, FIG. 6 shows a permanent magnet 121 for supplying a static magnetic field. Please refer to FIG. 7 for a current. It is supplied from an AC power source (not shown in the figure) via power lines 123, 125, and is fed into a transformer 127 and a bridge regulator 129 to the magnetic coil 119. The method and details of supplying current to the spiral coil are in the art As we all know, and it is not important in the essence of the present invention. -21-O: \ 65 \ 65722-910515.DOC \ 4 This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) 567078 A7

^ That is, referring to Figs. 8 and 9 ', another embodiment may provide a device similar to that described in the previous paragraph. This specific embodiment is an enlarged version of the embodiment shown in FIG. This second specific embodiment allows exposing part or the entire body to electromagnetic forces as shown in Figs. In this design, the main vessels (aorta, vena cava vessels) of the chest tube, external spinal lymph nodes, and the main blood tank (liver, spleen, lung, and heart) can be exposed to both time-varying magnetic fields and static magnetic fields (not shown in the figure). (Shown) to reduce patient exposure time. This device has a circular housing 130 'which contains a coil 119 and a strong permanent magnet 121. The circular housing 130 has an inner chamber 132 that is large enough to expose a body part of a patient 134 to a magnetic field. The housing 130 can be fixed to a narrow bed 136 made of a non-magnetic material. As in the previous embodiment, the timer 113 and the control mechanism 115 connected to an electronic panel can be located beside the bed. Ideally, the housing is made of a non-magnetic material such as wood or plastic. In another embodiment shown in Figs. 10 and 11, the same device of the embodiment shown in Fig. 11 can be used without a permanent magnet 121. As shown in FIG. 13, this specific embodiment also includes a coil support 250 for supporting the coil 19 and a tube wall 252. In another embodiment shown in FIGS. 14 to 16, it is a simplified version of one of the previous embodiments shown in FIGS. 10 to 13. For example, a solenoid of a magnetic coil ι57 is installed in a cylindrical housing 15 8. The cylindrical housing 15 8 series includes an elongated annular channel 15 9 formed therefrom. The magnetic coil 157 may be arranged in the cylindrical housing 158 and near the annular passage 159. The size of the housing and the annular channel should conform to a patient's limb, such as a patient's forearm 160 or upper arm 162, to allow the patient to be more mobile when exposed to electromagnetic forces. -22- O: \ 65 \ 65722-910515 D〇C \ 4 This paper size is applicable to China National Standard (CNS) A4 (210X297 mm) 567078 A7 ----- ---- B7 V. Invention ^ ~~ --- Therefore, this design allows comfortable and active limbs to be exposed to εν% of the present invention. Ideally, the cylindrical housing is made of a light non-magnetic material. This non-magnetic material includes plastic or wood. Moreover, the transformer m and the bridge regulator 129 (shown in FIG. 7_) together with a pair of contacts connected to a power supply μ]. The power supply is included in a small adapter box 15 ′ to easily obtain an AC from an AC The current of the power supply (not shown). The included adapter box 15 with a contact portion, a transformer, and a bridge regulator are connected to the coil 157 by two long cables 154 which can supply current to the coil 157. That is, referring to FIGS. 17 and 18, another specific embodiment may provide a device similar to the specific embodiments shown in FIGS. 10 to 13. This specific embodiment is an enlarged version of the specific embodiment tf shown in FIGS. This embodiment allows part or the entire body to be exposed to electromagnetic forces as shown in Figs. In this design, the main vessels (aorta and vena cava vessels) of the chest tube, external spinal lymph nodes, and the main blood tank (liver, spleen, lung, and heart) can be simultaneously exposed to electromagnetic forces (not shown in the figure) to Reduce patient exposure time. This device has a circular housing 260 containing a coil 119 and includes an internal chamber 262 sufficient to expose a patient 204 body part to a magnetic field. The housing 260 may be fixed to a narrow bed 245 made of a non-magnetic material. A timer i 13 and a control mechanism 115 connected to an electronic panel can be positioned beside the bed. Ideally, the housing is made of a non-magnetic material such as wood or plastic. A magnetic field can also be provided in another specific embodiment described in FIGS. 19 and 20. This device may be in the general shape of a U-shaped housing 200. Referring now to FIG. 22, a part of the body of a patient 204 may be exposed to a homogeneous electromagnetic field between the side walls 208 of the device housing 200 according to the present invention. The device can be wood, plastic, -23- O: \ 65 \ 65722-910515.DOC \ This paper size is applicable to China National Standard (CNS) A4 specification (210X297 mm) 567078 A7 ^ __ — Β7 V. Invention (M) or other non-magnetic material to avoid interference with the application of electromagnetic fields to a patient's body part. Please refer to FIG. 19 again. What is installed on the panel 212 is a timer 214 and a control mechanism 216. These two systems are connected to an electronic panel 218 as shown in FIG. 20 to change and control the intensity of the electromagnetic field. With duration. As shown in FIG. 20, disposed on each inside of the side wall 208 is a coil 224 'for supplying a time-varying magnetic field. These side walls can be used as support to maintain the coils in Helmholtz configuration. FIG. 21 is a diagram showing an electromagnetic flux generated by the opposite Hemholtz coil 224. Please refer to FIG. 24. A current is supplied from an AC power source (not shown in the figure) through the power lines 230, 232, and is fed into a transformer 234 and a bridge regulator 236. To reduce the heat generated by the current in the coil, a capacitor 23 8 and a resistor 240 can be used to reduce the effective current 224 of the magnetic coil. A fan can be used to cool the resistor. The methods and details for supplying current to the coil are well known in the art and are not essential to the nature of the invention. A slight variation of this specific embodiment is shown in FIG. The specific embodiment here uses similar equipment, but the housing 200 is upside down and fixed next to a narrow bed 245 made of a non-magnetic material. The magnetic flux generated by the coil is now perpendicular to the axis of the body 204. The timer and control mechanisms 214 and 216 can be easily placed by the bed. Another specific embodiment of the device of the present invention is described in Figs. The device may be a saddle 280. Referring now to FIG. 28, a saddle is placed on a limb or a body part 282 according to the present invention to expose a patient to a homogeneous electromagnetic field. The device can be made of wood, plastic, or other non-magnetic materials. O: \ 65 \ 65722-910515.DOC \ 4-24-This paper size applies to China National Standard (CNS) A4 (210X297 mm) 567078 A7 _______ B7 V. Description of the invention (22) It is used to avoid interference with the electromagnetic field of a patient's body part. As shown in Figures 25 and 26, the saddle is connected to the control unit 29 through a cable 288. The control unit includes a timer 292 and a control mechanism 294, which are connected to an electronic panel (not (Shown in the figure). It is used to change and control the intensity and duration of the electromagnetic field. As shown in Fig. 26, a coil 298 is arranged inside the saddle wall to provide a time-varying magnetic field. Please refer to FIG. 24. The circuit used in the previous embodiment is the same. FIGS. 19 to 23 can be used to transmit current to the coil 298 in the embodiment described in FIGS. 25 to 28. A current can be supplied from an AC power source (not shown in the figure) via the power lines 23, 232, and fed into the transformer 234 and the bridge regulator 236. To prevent current from heating the coil, a capacitor 238 and resistor 240 can be used to reduce the effective current of the magnetic coil 298, and a fan can be used to cool the resistor. The means and details for supplying current to the coil are well known in the art and are not essential to the nature of the invention. There are two additional methods of generating the electromagnetic field of the present invention. The first is through modulation of a continuous line of 27.12 MHz, which can transmit private magnetic waves (that is, focusing on the electromagnetic field of the present invention in any direction) at the same frequency of the present invention through space (transfer wave). Moreover, by altering the same frequency of the present invention, a high-intensity electromagnetic field and solution can be generated by a TesU coil (transmission wave). This last-designed electromagnetic field can pass through space so that a patient lying in bed or sitting close to one of the sources can be treated without looking at the device. For a patient suffering from skin or internal injury pain according to the method of the present invention, a patient's limb (e.g., one hand or-part of the arm) can be inserted into the opening 104 'and the portion can be extended through the channel 105. The power will then turn on so that O: \ 65 \ 65722-910515 DOC \ 4 -25-

567078 A7 B7 V. Description of the invention (23) &quot; Supply a current to the spiral coil 119. The magnetic flux lines generated by the magnetic field in space 107 are shown in Figure 3, and it can be seen that the variable and static magnetic flux lines are included. It can be found that when the electromagnetic field is more than i Hertz to less than about 300 Hertz Treatment is most effective when applied at very 2 frequencies. The spectral content of a time-varying magnetic field is smaller than about 120 Hz and its harmonics. Reference may be made to, for example, FIG. 5 ^ These frequencies f have a static magnetic field element having a strength of about 0.3 to about 0.8 mT rms, and these electromagnetic forces can be used alone or in combination with about 40 to about 80 mT (about 400 to about 800 Gauss) in combination with a homostatic magnetic field. Therefore, there are two static magnetic fields: the generation of one is a time-varying magnetic field of the joint, and ideally has a low magnetic flux density of several micro-magnetic flux densities to a maximum of about 0.3 to about 0.8 mT (rms), and provides about 40 to about 80. A magnetic flux density of the claw is &lt; Hydromagnet, which is equal to about 400 to about 800 Gauss. The relationship between the instantaneous current supplied from the circuit to the magnetic coil is as a function of time in a series of waveforms as shown in FIG. As shown previously, time-varying magnetic field applications with frequencies from a few hertz (over 丨) to less than about 300 Hz, and static magnetic field elements with a strength of about 0.3 to about 0.8 mT used alone, or A synchronous application of a homogeneous static magnetic field of one to 40 to 300 or about 400 to about 800 Gauss constitutes an essential (important) feature of the method of the present invention. The damage recovery effect of the method and device observed by the patient can be obtained by supplying only the time-varying electromagnetic field described in this patent, or combining the electrostatic magnetic field. However, each element and their combination that are usually separated can demonstrate varying degrees of effect on the proliferation of peripheral blood mononuclear leukocytes, &apos; field cells (PBMCs). This can be clearly seen with this patient in Figure 29, which shows that when applied from the normal body (loo% cell proliferation control is PBM (:: Μι), the proliferation is stimulated by cell division without O: \ 65 \ 65722-910515.DOC \ 4

567078 A7 B7 V. Description of the Invention (24) ——When PBMCs obtained by any (EMFs) of the present invention are required, the effects of different degrees of cell proliferation are demonstrated by different types of magnetic fields. Static and time-varying fields ^ A combination of applications can generate an increase of 11.1% in PBMCs diffusion (p &lt; 〇.〇i Student „τ ,, test), and applications of a time-varying magnetic field can generate PBMCs diffusion alone (P &lt; 0 · 001 Student 67% reduction in the '· Τ ·' test), and the application of a static magnetic field has no significant effect on the diffusion of PBMCs. For the greatest benefit from treatment, the magnetic field ideally can be in the limbs of a patient in about minutes to about 8 hours The optimal exposure time can be calculated, so a blood volume equal to the entire blood volume of the patient is exposed to the magnetic field at least once. The exposure frequency can vary from a maximum of about 30 minutes to 7 hours per day to a minimum of about 30 minutes a week. It determines the restoration of the observed damage and the restoration of the observed damage. The application of the private magnetic force according to the present invention can be used to isolate peripheral blood mononuclear white blood cells (PBMCs) to modulate their diffusion mode and their systemic effect Application with external time-varying magnetic field or combined with static variable magnetic field can treat patients with chronic skin ulcers, chronic injuries, resilience other than hypoperfusion myocardium, Fractures and partial denervation are described in the following examples. The following examples describe the effectiveness of the method of the present invention. However, these examples only describe the present invention and do not constitute a limitation on the scope of the present invention. Example effects The electromagnetic field (EMFs) effect used by the present invention on peripheral blood mononuclear white blood cell cells (MCs). Example 1 • Different electromagnetic field effects on PBMC diffusion O: \ 65 \ 65722-910515DOC \ 4 ______ -27- ^ Zhang Ruler Thin — Outfitting ............... Line 567078

Peripheral blood mononuclear white blood cells (PBMCs) can be obtained by venous destruction and fractional distillation on the final gradient. The portion containing PBMCs was washed three times and remixed to 5 x 106 cells per milliliter in phosphate buffered saline. Each pin of 5 X 106 cells of PBMCs can be divided by 0.2 ml. The "m / ml" which can be divided and the cell division can be placed in small plastic tubes. 4 parts will be formed (each part has 3 tubes). First Part will be shielded from the magnetic field. Part 2 can be exposed to the time-varying electromagnetic field static magnetic field combination according to the present invention, part 3 can be exposed to the time-varying electromagnetic field only according to the present invention, and part 4 can be According to the present invention, it is only exposed to the static magnetic field. These 4 parts are prepared without cell division (control) and placed under the same experimental conditions. All tubes are in a carbon dioxide humidifier bacterial incubator (Foma Scientific) Mod 3325 Double-Chamber C02-water jacketed bacterial incubator) was cultured at 37QC. After a latency period of 58 hours, 311_thymine (5-6 μ Ci / mM final concentration) will be added to all tubes and cultured An additional 14 hours. All tubes can obtain results in 72 hours, and the strips are washed with glass fiber filter paper using a cell harvester (Skraton, Tranby, Norway). H-thymus χ »Bite binding can be used by using a Liquid scintillator count (Beckmann Mod LS 6000 SE). The average number of counts per minute can be obtained by 3 times in each sample. Cell viability is always greater than 90% 'It is determined on the basis of trypan blue exclusion. Figure 2 7 Accompanying this patient showed the effect of magnetic field on PBMCs obtained from normal body. The combined static and time-varying electromagnetic field can produce a 11% increase in PBMCs diffusion (P &lt; 0.001 student `` τ '' test). Time-varying electromagnetic field The cell spreading (P &lt; 0 · 001 Student ΠΊΓ test) produced only about 67% reduction. Static magnetic field O: \ 65 \ 65722-910515 DOC \ 4 This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) -28-

Binding

Line 567078

No effect on PBMCs diffusion. Therefore, in experiments, a magnetic field effect is demonstrated on isolated p] gMCs, which is different from each type of magnetic field or its combination.

Equipment ίεΑΙ: Electromagnetic effects on physical injury (safety and tolerance studies) Since electromagnetic fields cross biological tissues, they can produce effects on circulating PBMCs. The time-varying private magnetic% effect of the present invention, alone or in combination with a static magnetic field, can be observed on chronic skin injuries even after exposing a body part at the injury location to the electromagnetic force of the present invention for only about 30 minutes to 丨 hours Here. During this time, it is common to see a wound dry out and reduce its diameter. Order

The magnetic field generated by the device described in this patent is as safe as the following exposure limits recommended by the World Health Organization (WHO). However, the fact is that this is a pioneering procedure, and the execution of the following study illustrates the safety of the external application of the magnetic field of the present invention to the human body. After submitting an automatic permit to join the magnetic field agreement, each patient will have a complete clinical history, physical examination, blood chemistry, cell blood count, and urine analysis before the magnetic field is exposed. An ECG can be performed before, during, and after exposure to the electromagnetic field, and blood pressure can be measured. Three groups of volunteers can be formed. The first group is exposed to electromagnetic forces (EMFs) at 30 minutes daily. The second group is 30 minutes twice a week, and the third group is 30 minutes once a week. These three allow one year without negative side effects. In the last 5 years, more than 100 patients have been exposed to an external magnetic field 1 to 7 hours a day in accordance with the method of the present invention, working 7 times a week. During these treatments O: \ 65 \ 65722-910515 DOC \ 4 -29-

567078 A7 B7 5. In the description of the invention (27), no adverse or negative side effects will be observed in any of these patients during or after exposure to electromagnetic forces. The magnetic field application by the method and device of the present invention shows that there is no negative effect even on the electrocardiogram of patients with heart disease. This treatment does not have any adverse effects on the patient's motor muscles, sensory nerve function, or conduction. Linqing experiment The following is a clinical experiment to prove the therapeutic efficacy of the present invention when applied to the limbs of patients with chronic injury medical records. These chronic injuries have not previously responded to other curative treatments. Following good clinical practice as defined by the US Food and Drug Administration (Phase 丨 Study) ^ One of the guidelines for Phase 1 was provided to the Juarez Hospital Institutional Review Board / Ethics Committee and was approved on September 24, 1995. Follow talented procedures to monitor clinical trials. A total of 42 patients will receive the study. The following clinical experiments demonstrate the efficacy of the treatment of the present invention when applied to the limbs of patients with a chronic injury medical history. Chronic injury has not previously responded to other curative and curative patients. Electromagnetic stimulation, as defined below, is applied to the arm 2 to 3 months, 7 times a week, 2 to 3 hours a day. All exposed tissues of the arm are considered under the combined effect of static and / or time-varying magnetic fields. The intensity of the applied electric field in each segment of the arm will change with the radius according to Faraday's law. "25 patients are allowed to be treated for chronic leg ulcers. Each patient's complete nursing record contains a signed voluntary consent form. Their clinical records include definitions of venous and arterial disease, other underlying diseases, ulcer medical records, and : \ 65 \ 65722-910515 D〇C \

Binding

Line 30- 567078 A7 B7

The treatment used. Only untreated injuries will be tracked at the time of examination. Each ulcer will be described and proven by photography, size, and approximate calculated area (length x width). When more than one ulcer is present, an approximate total ulcer area: can be determined. Laboratory tests include blood chemistry, blood tests, electrocardiograms, and other diagnostic tests. Peripheral circulation is through Doppler color ultrasound, arterial tomography, vein and light photography, and blood evaluation. The track records consisted of a periodic photographic record of the chronic leg ulcer medical history, a week of clinical notes, and a report of a physical examination. I. Chronic venous leg depletion In addition to leg ulcers, primary varicose veins, deep vascular embolism, diabetes, hypertension, rheumatoid arthritis, obesity and cardiovascular disease, patients with potential pain will be accompanied Pain in leg ulcers, edema infections, and restricted movement. Fan J3: Elderly woman with primary varicose veins Patient number 1 is a 75-year-old woman affected by primary varicose veins and having leg ulcer pain over 9 months. Ulcers can be accompanied by pain, edema, and limited activity. The electromagnetic stimulation according to the invention can then be applied to any of her arms for about 2 hours per day for 5 months. No other medication is required during this period. After the first two weeks of treatment, pain and edema disappear and the patient becomes fully mobile. The ulcers will recover as granulation tissue and will be treated for the entire 5 months after the start of the electromagnetic force treatment. With continuous treatment, patients will become more attentive and optimistic about their life and memory improvement. After the cancer has recovered, the patient can remain under observation for a further 8 months, and all of this time will pass O: \ 65 \ 65722-910515DOC \ 4 * 31-

567078

During the course, the patient will remain without symptoms. Young man with primary varicose veins Patient No. 2 is a 33-year-old male with primary varicose vein pain with pain and edema in a 4 cm cm leg ulcer over 9 months. According to the present invention, the electromagnetic stimulation can be applied to his arm 2 days a week, 5 days a week without additional treatment. ^ One week after the start of treatment, the pain and edema will disappear, and the ulcer will fully recover after 6 weeks. However, when the patient returns, he will have new legs in all the epidermis caused by trauma rather than recurrence. ulcer. A second series of electromagnetic force treatments can then be applied to any of his arms for 4 days, 2 hours a day. I mouth is the same as the first time, and the second treatment can recover within one week. Example 31: Young woman with primary varicose veins Patient number 3 is one of 66-year-old women who has suffered from primary varicose vein pain in a leg ulcer of 6 cm in length over 1 year. Ulcers can be accompanied by pain, edema, and limited activity. The only treatment she received was for 3 months, 3 days a week, 2 hours a day using electromagnetic stimulation on any of her arms. After the first 2 weeks of treatment, pain and edema will disappear and the patient will become fully mobile. 3 months after the start of the treatment, the treatment increased the growth of granulation tissue and reduced her wound area by about 48%. Example 6: Young woman with deep vascular embolism Patient number 4 is one of the 38-year-old women who has suffered from deep vascular embolism for more than 8 years and a 6 cm² ulcer for more than 7 years. Ulcers are accompanied by pain, edema, and O: \ 65 \ 65722-910515 DOC \ 4 -32-

567〇78 A7 B7 V. Description of the invention (30) Limit activities. During this time, the patient could receive specific medical and surgical treatments, including venous excision and skin grafting procedures, and mobile applications of bandages on ulcers, but they could not improve her condition. The electromagnetic stimulation according to the present invention can be maintained for 5 months, 5 days a week, 2 hours a day = and then applied to any of her arms. During this time, the patient can continue to use her loose bandage on her leg ulcers before electromagnetic therapy. After the first two weeks of 'η treatment, the pain and edema will disappear, and after 6 weeks &lt; she will become fully mobile. After 5 months of treatment, the base of the ulcer is superficial and its size will be reduced by about 80%. Fan Ye 7: Middle-aged women with deep vascular embolism and superficial venous insufficiency. Patient number 5 is an obese 41-year-old woman suffering from deep vascular embolism and superficial venous insufficiency in both lower limbs for more than 7 years. The wounded area is accompanied by pain, edema, itching, and limited activity. During this time, she received regional and systemic medical treatment, as well as Litton # ^ 〇 〇 〇 Electromagnetic stimulation was applied to her two arms that were ineffective in improving her condition, and then applied to any of her arms 2 hours a day, 3 days a week. After the first two weeks of treatment, the pain and edema disappear, and within two months, the ulcers can fully recover, and the electromagnetic force exposure can be temporarily suspended. After 4 months, the ulcer will recover and the patient will have no symptoms. Fan Hi: Middle-aged woman with deep and superficial venous insufficiency and arterial hypertension Patient number 6 is an obese 59-year-old woman who is one of the chronic leg ulcers suffering from deep and superficial venous insufficiency and arterial hypertension pain for more than 1 year. Cancer ulcers are accompanied by pain and edema, large areas of erythema, and limited activity. During this time, arterial hypertension can be maintained under control, and the ulcer can be used and cannot be effectively changed. O: \ 65 \ 65722-910515.DOC \ 4 -33- This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 (Mm)

Binding

Line 567078 A7 B7 V. Description of the invention (31) Traditional medical and surgical treatment for her condition. The electromagnetic stimulation can then be applied to any of her arms for about 2 months, 3 days a week, 2 hours a day, and she can continue to receive the same antihypertensive treatment as before. After the first two weeks of electromagnetic therapy, pain and edema will disappear and the ulcer will be covered by scars within 3 weeks. The area of erythema can be reduced within 4 weeks and the disease will begin to fall off and be replaced by the tissue that left the scar. Example 9: A woman with lymphadenopathy and superficial venous insufficiency Patient number 7 is one of the pains of lymphadenopathy and superficial venous insufficiency caused by her left leg when she was 2 years old. A 42-year-old woman. In addition, she had an enlarged wound area over the entire 395 cm leg for more than 5 years, accompanied by pain, edema, and limited movement. During this time, she had undergone compressive mobile bandages, medical treatments, and surgical interventions, including skin grafts that did not improve her condition effectively. Electromagnetic stimulation according to the present invention can then be applied to any of her arms for more than 6 months, 5 days a week, 2 hours a day. During this treatment, she can continue to use the loose loose mobile stretcher used before the electromagnetic treatment. Additional treatment is given to her. /, After two weeks of electromagnetic treatment, the pain and edema will disappear, and after 4 to 8 weeks (after that, she will become fully mobile. After the week of electromagnetic treatment, angiogenesis can penetrate the wound area Enough granulation tissue appeared and appeared. At week 8, she would become fully mobile. In the treatment? Month of injury can be completely decumbent. 1 case 1 0: the number of women with superficial venous insufficiency number 8 is more than 7 Surface vein function with 7 cm 2 leg ulceration I: \ 65 \ 65722-910515 DOC \ 4 -34-

567078 A7 ______ B7_. _ V. Description of the invention (32) One of the incomplete 52-year-old woman. Ulcers can be accompanied by pain, edema, infection, and limited activity. The electromagnetic stimulation can be maintained for two months, 3 days a week, and applied to any of her arms 2 hours a day. No other treatment is needed during this time. Pain and edema will disappear after the first week of the patient becoming fully mobile. Ulcer size will decrease by more than 95/0 after 1 month of treatment. Fan-Example 1 1: Elderly women with superficial venous insufficiency Patient number 9 is a 62-year-old woman who has suffered superficial venous insufficiency with a chronic leg ulcer and pain for more than 15 years. The week before ulcer scars are allowed to study can become very painful, at which point a 0.5 cm² area of plasma bleed is produced. Private magnetic stimulation can then be applied to any of her arms for two weeks, three days a week, two hours a day. The ulcer can recover within 3 days, and the patient will remain asymptomatic the following month. Case 1 2 ·· Middle-aged woman with superficial venous insufficiency, artificial ulcer and neurodepression. Patient No. 10 is one of the painful leg ulcers that has been maintained by the patient for approximately 25 square centimeters over 21 years. A 51-year-old woman. Injuries can be accompanied by pain, edema, and limited activity. During this time, the patient has undergone medical treatment, but it cannot effectively treat her condition. According to the invention, the electromagnetic stimulation can then be applied to the patient's arm for 2 months, 3 days a week, 2 hours a day. No other treatment is required during this time. After 4 weeks of treatment, the pain and edema will disappear, and after ^ months of treatment, the ulcer can be reduced by about 32%. 1.1. Pathology of chronic venous leg ulcers and / or venous diseases with limited beneficial effects &gt; f In addition to chronic leg ulcers and venous diseases, non-edema scars, group O: \ 65 \ 65722-910515 .DOC \ 4 -35-

567078

Includes obese potentially painful patients with very high body mass index (over 40 kg / M2) and skin gangrene. Pain, edema, and infection are associated with chronic leg ulcers.魁 &quot; Qui】 3 • Surface and deep venous insufficiency, not scarring of edema, obesity and chronic venous leg ulcers. This example describes the treatment of a group of 4 patients. The patient (patient numbers 11-14) was a woman aged 6 to 7 years old who suffered from superficial and / or deep venous insufficiency, edema of muscles, obesity, and chronic venous leg ulcers from 9 to 17 years. Men. All patients have been prophylactically used. Medical and surgical procedures are currently recommended to reduce venous hypertension and / or use skin grafts to cover the wounded area. All of these treatments are not helpful in improving their condition. The electromagnetic stimulation according to the present invention can then be applied to any arm of 11 to 14 per patient, 2 hours a day, 3 days a week. Two weeks after the start of the electromagnetic force treatment, the pain will decrease and the ulcers will appear dry and deep. These changes can temporarily improve the patient's condition, however, the size of the ulcer remains the same, and in some heart conditions can increase the size of the ulcer during electromagnetic force treatment. These patients can be removed from the record. -㈣Μ: Obese women with severe superficial venous insufficiency, high body mass index, and chronic venous leg ulcers. Patient number 15 is a 46-year-old woman suffering from superficial venous insufficiency. Since she is 13 years old, she has a very southern physical index (more than 4 〇kg / jy [2) and the large chronic venous leg ulcer with pain in her left leg has been treated for more than 4 years. During this time, she received preventive measures and recommended medical treatment in the special center. -36- O: \ 65 \ 65722-910515.DOC \ 4 This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) ) 567078 A7

Wo Moon Dagger? Wenshan is in her condition. The electromagnetic stimulus according to the present invention is then used for 4 months. 0τ is time, 3 days a week, applied to any one of her arms every hour. In the two weeks after the start of the electromagnetic therapy, 踊: 踊 will decrease, the effluent will stop, and the edge of the cancer will appear to be inflamed '. However, the size of the field will remain the same during the electromagnetic force during the treatment period. This patient called Huo _ Ji Ji Lu removed. Middle-aged woman with deep vascular embolism and cutaneous gangrene Patient number 16 is one of those who suffered from deep vascular embolism and pain in the back of her right leg for more than 4 years. During this time, she received preventive measures and recommended medical treatment in the special centre without improving her condition. The electromagnetic stimulation according to the present invention was then applied to any of her arms for 4 months, 3 days a week, 2 hours a day. Two weeks after the start of the electromagnetic force treatment, the pain will decrease and one of these ulcers will become superficial. After that &apos; &apos; Beiyang will begin to form &apos; and the patient will be removed from the record. A skin biopsy change will be consistent with the patient's medical skin gangrene. Π · Arterial leg ulcers This group is caused by general arteriosclerosis, diabetes, arterial and / or venous hypertension, rheumatoid arthritis, obesity, cardiovascular disease and vascular gangrene potential pain in addition to chronic arterial leg ulcers Of patients. Residual pain, edema infections, and limited activity are accompanied by leg ulcers. Example 16: Old woman patient with severe partial anemia and diabetes patient number 17 is one year old who suffers from 3 arterial ulcers and diabetic pain in a 22 cm 2 wound area with severe pain on her left leg over 4 months Old women, this intense pain prevents patients from sleeping at night. In this paragraph -37- O: \ 65 \ 65722-910515 DOC \ 4 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 567078 A7

Time ’, she received medical treatment, but she was ineffective in improving her condition. The electromagnetic stimulation according to the present invention can then be applied to her arm for 7 months, 4 days a week, 3 hours a day. During this time, he does not need to administer additional treatment. After 4 weeks of treatment, the skin temperature will increase 'and the superficial blood vessels will become more prominent in response to increased angiogenesis. The bottom of the ulcer shows a rich granulation tissue that responds to increased angiogenesis. Pain can be significantly reduced, allowing patients to sleep at night. After 7 months of electromagnetic treatment, the 3 ulcers were fully recovered. During this time, the patient's neural agility and memory will improve significantly. This patient tracked for another year. During this time, the ulcer will remain healing. Fan 1LLL: The main patient number of old women with rheumatoid arthritis and arteriosclerosis is U. Pain in two arterial ulcers associated with rheumatoid arthritis and arteriosclerosis. -8G-year-old woman. 4 knee surgery. The socks produced about 35 square centimeters. These injuries persist for up to two months and are accompanied by intense pain that wakes the patient up at night. Grafting of the skin and skin treatment could not effectively improve her condition. The electromagnetic stimulation according to the present invention was applied to any of her arms for 4 and a half months, 3 days a week, 3 hours a day. No other treatment was given during this time. Four weeks after the start of electromagnetic treatment of pain will be reduced, so that patients can feel at night: skin; f temperature will increase the mouth 'and the surface vessels will respond more significantly to increase angiogenesis. The bottom of the ulcer responds to the rich granulation tissue that increases angiogenesis. Within two months, the patient had no pain and the wounded area fully recovered in 4 1/2 months. During this time, the patient becomes more sensitive, her fever and her memory can improve. Patients will be followed for an additional 8 months. During this time, the ulcer will remain O: \ 65 \ 65722-910515DOC \ 4 -38- V. Description of the invention (36 recovery. Example 1 8 ~: Older male patient with general arteriosclerosis No. 19 is on the front of his leg A 70-year-old man suffering from chronic arteriosclerosis caused by general arteriosclerosis in 65 square centimeters for two years. The femoral arterial machine (1 ume η) will be reduced by 85%, and the anterior tibial artery lumens will be 90% narrow. The ulceration will be accompanied by the intense pain that keeps the patient awake at night. The five methods of skin grafting and drug treatment effectively improve his condition. The electromagnetic stimulation according to the invention is 12 months, 3 days a week, and 3 hours a day. Used in any arm of him. No other treatment is needed during this time. After two weeks of treatment, the bottom of the ulcer will be red, and the tendon will be epithelialized, and the pain will be significantly reduced, allowing the patient to sleep at night and improve activity. Two and a half months after the skin temperature increases, the superficial blood vessels will change significantly to increase angiogenesis. The bottom of the ulcer shows a reaction that increases angiogenesis of the pyloric bud tissue and the patient will have no pain. At this time In the meantime, the patient will be: more optimistic 'mind sense' and his mood can be significantly improved. The overall reduction in the area of the wound surface on his leg before December of the treatment was about 80%. Fan-like arteriosclerosis, A patient with a superficial and deep venous insufficiency and rheumatoid arthritis, patient number 20, a 57-year-old woman with general arteriosclerosis, superficial and deep venous insufficiency, and rheumatoid arthritis pain. In addition, she has a 9 month old ulcer. An area of 6.5 square centimeters in the front of her leg, and another moderate foot and ankle ulcer of 10,000 square centimeters. Electromagnetic stimulation was then available for about 7 months, 4 days a week, and 3 hours a day. Apply to any arm of the patient. No other treatment is required during this time. ° O: \ 65 \ 65722-910515 DOC \ 4 V. Description of the invention (37) After 3 months of electromagnetic therapy, moderate foot. Manic The cancer will recover, and the ulcers in the front of her legs will heal within 7 months. During this time, her mood will be improved. WU: The middle-aged woman patient with vascular gangrene is affected by-Shi Xishen One of 45-year-old women suffering from pain in the right leg with vascular necrosis. Reconstructive Surgical Surgery to Cut and Rescue Her Legs-Reliable Man X Prosthesis in the Other-The posterior leg of the leg leads to arterial occlusion two years later, resulting in a pain lasting more than 5 months-very painful 23 cm cm ulcer . Pain and edema will frustrate her. Her movements are restricted. During this time 'she received medical treatment but could not relieve her condition. Before electromagnetic therapy was applied to the patient, she needed local anesthesia when her ulcer was cleared' 、 The electromagnetic stimulation will be applied to her hand for 5 hours a day, 5 hours a week, i hours a day. 'During this period, her cancer will be cleaned every day. No other investment is required during this time. Treatment. Born after 4 weeks of treatment, the pain and edema will disappear, no more anesthesia cleaning: ulcers, and 4 people will become fully mobile. After 2 months of treatment, the granulation tissue and ulcers appearing at the bottom of the ulcer can completely recover. ^ Example 2 1 _ · Arterial hypertension and deep vascular embolism controlled by code law Middle-aged man, patient number 22 is a chronic leg itch of 20 cm 2 in length that cannot control arterial hypertension and deep vascular embolism pain over 7 years A 54 year old man. The wounded area is accompanied by pain, edema, and limited movement. During this time, he received treatment, including antihypertensive treatment, but was unable to improve his condition. When he continues to receive the same antihypertensive treatment as before, the electromagnetic stimulation can be applied to the temple for about 4 months, 3 days a week, and 2 hours a day.

The paper size is suitable for wealth ® ® 297 mm) 567078

One arm. Ulcer pain, edema, and necrosis will disappear after the first 3 weeks of treatment. After 6 weeks of treatment, he can become fully active and the ulcers can fully recover within 3 months of treatment. Fan: Uncontrollable arterial hypertension, superficial venous insufficiency, and type 2 diabetes and obesity. Female patient number 23 is one of the two square feet ulcers of more than 2 years and 3 months in length. He is 60 years old. Old woman. During this time, she received medical treatment including antihypertensive treatment, but it did not improve her condition. The electromagnetic stimulation according to this method can then be maintained for 4 and a half months during her antihypertensive treatment with 3 days a week and 3 hours a day using any of her arms. During electromagnetic therapy, the patient develops a third-degree injury from trauma. After one week of treatment, pain, edema, and leg ulcers that are 3 months old will disappear. After 6 weeks of electromagnetic therapy, the injuries caused by subsequent trauma will be restored. The patient is allowed for an additional year and the ulcer can remain recovered. Fan_Example 2 3 .: Old woman with general arteriosclerosis Patient number 24 is one of the common arteriosclerosis and a chronic leg ulcer with a pain of 1.2 square centimeters more than one year old 85-year-old woman. During this time, she received medical advice but was unable to alleviate her condition. The electromagnetic stimulation according to this method can be applied to any of her arms for 2 months, 5 days a week, 2 hours a day. After 2 weeks of treatment, the pain and edema will disappear. These changes occur after a sensitive inflammatory response near the growth of granulation tissue ulcers, which covers the bottom of the ulcer that increases angiogenesis. In 3 -41-O: \ 65 \ 65722-910515.DOC \ 4 This paper size applies Chinese National Standard (CNS) A4 specification (210 X 297 public love) 567078 A7 * ___B7 V. Description of invention (39) --- Within a month, the area of ulceration can be reduced by more than 70%. • Common law control type! Diabetes and Hypercholesterolemia in Men Patient No. 25: A 24-year-old man with uncontrollable type 1 diabetes and hypercholesterolemia in his left foot for 3 months. The patient received Bureau 4 Surgery and medical treatment could not effectively alleviate his condition. Electromagnetic stimulation can be applied to any of his arms for 2 hours, 5 days a week, 2 hours a day. After 3 hours of treatment, the bottom of the deep ulcer is on the skin surface. Ulcers can be fully recovered in 4 weeks. Patients need to remain unsymbolized for an additional 4 months. III. Compression rupture cancer group This group includes patients with hemiplegia, deep blood vessel embolism, and obesity-related pain in addition to the pressure ulcer. Pursuing cancer can be accompanied by infection. Middle-aged Incontinence Hemiplegia Woman with Fan Leg Injury Patient No. 26 is a 64-year-old half-body itching and incontinence woman with 2 injuries. The 24cm injury on her left leg was caused by an attempted surgical recovery-electric blanket love injury 'and it took 6 months. The second injury was at the time of 4 months. Stage 5 Yark0ny-Kirk classification sacral ulcer in a lying position. During this time, she received systematic antibiotic treatment ’and 3 attempts to surgically recover her injuries. These treatments did not improve her condition. The electromagnetic stimulation can then be applied to any of her arms for more than 8 1/2 months' 7 days a week, 6 hours a day. Patients receive nurses 24 hours a day and continuous systemic antibiotic treatment. No additional injury treatment is required during this time. After 6 weeks of leg healing with electromagnetic therapy, Dizi's cancer infection can be controlled O: \ 65 \ 65722-910515.DOC \ 4 -42- 567078 A7 B7

V. Description of the invention (40)

At the additional 3 ill, the magnetic field is connected to S, al / tai ~ — 山 — domain will be in

It will disappear eventually. After an additional 3 months of electromagnetic treatment, the supine ulcer can fully recover. The old woman patient Fan with ulcer and deep vessel embolism number 27 is sitting in the same position 8 to 12 hours a day. She suffered from deep vessel embolism causing her left ischial tuberosity to produce 60 square centimeters of pain in 18 months. One of the obese 90-year-old women with edema, hemorrhage, fragile, purple spindle, and high pressure ulcer. Pain and edema are accompanied by ulcers. During this time, the patient received medical treatment including regional injury cleanup, but treatment could not improve her condition. The electromagnetic stimulation can then be applied to any of her arms for more than 5 months, 7 days a week, 2 hours a day. She can continue to receive regional injury cleanup, but during this time she does not need to administer additional treatment. After 2 weeks of electromagnetic therapy, pain and edema will disappear, except for the unhealed 1 x 10 mm area of the skin that cannot be treated because of sitting under constant pressure. During the treatment, her skin resistance will increase. Skin color will be pink in the morning and bright red after 8 to 12 hours of sitting. After 4 months of treatment, the ulcer can fully recover and the skin will become normal. IV. Chronic injuries This group includes chronic injuries other than chronic injuries, and peripheral arterial disease. The paper size applies Chinese National Standard (CNS) A4 specifications (210 X 297 mm) 567078

DISCLOSURE OF THE INVENTION Patients with severe disease and painful peritonitis. Pain, edema, and infection can be accompanied by chronic injury. : Elderly male infected with surgical injuries Patient number 2 8 is one of 78 elderly men with a 126 square cm infection trauma after a long and complicated abdominal surgery. Magnetic pen stimulation can be applied to any of his arms for 1 week per day for 3 weeks. After 2 weeks of treatment, the infection will disappear and the injury can be surgically sutured because granulation tissue and injury recovery are optimal for this procedure. : Senior man who has not been treated for trauma Patient number 2 9 is one of 73-year-old men with one of the lower extremity arterial diseases associated with smoking, diabetes, and general arteriosclerosis. Chronic lower extremity anemia for several years. Severe local anemia of the leg was apparent last year and the patient underwent surgical resupply of the pulse officer. However, three and a half months after the operation, the trauma on his left thigh and foot did not recover, and the knee trauma remained unhealed by 30 cm2. According to the invention, the electromagnetic stimulation can then be applied to any of his arms for 5 months, 3 days a week, 2 hours a day. No additional treatment is required for him. After 4 weeks of electromagnetic therapy, thigh and foot injuries can be recovered, and injury retraction and epithelial growth will continue to treat knee injuries, reducing the area of injury to approximately 97% within 5 months. Injuries can be fully recovered in an additional month. A middle-aged woman with an untreated ulcer. Patient number 30 is one of the lower extremity arterial diseases associated with smoking. 65-year-old woman. The result of the trauma can develop into one of the very painful ulcers within two weeks of the reduction in activity. An infection of 2 · 6 cm² bruises. This damage resists auxin treatment 0

Binding

O: \ 65 \ 65722-910515 D〇C \ 4

567078 A7-~~ __?! _ 5. Explanation of the invention (42) According to the present invention, in addition to a new antibiotic treatment, electromagnetic stimulation can then be applied to any of her arms 2 days a day, 5 days a week. After two weeks, the infection can be controlled, edema and pain will be significantly reduced, and movement will be almost normal. The bottom of the previously uncured ulcer showed abundant granulation tissue. After one week, the patient will have no symptoms, and since the electromagnetic force treatment is started, the ulcer can be recovered within 1 month. : A middle-aged man infected with a shoulder injury Patient No. 31 is a 57-year-old man under the intense compression of an itching old scar that developed very painful abscesses on his left shoulder within two weeks. Injuries can be controlled with antibiotics, but after two weeks, pain, edema, inactivity, and an unhealed injury of 3 cm² remain. According to the present invention, the electromagnetic stimulation can then be applied to any of his arms 5 days a week, 2 hours a day. After three weeks, pain, edema, and inactivity will disappear 'and injuries can be reduced by more than 70%. The ulcer can be completely restored after two weeks. V. Avoiding the dysentery of _11, which is poor and flat, This group includes patients with recoverable but hypoperfused myocardium, who are not candidates for coronary artery replacement for blood supply. Arteriosclerosis is a general disease that causes, for example, lower extremity arterial disease (chronic arterial leg ulcer), cardiac muscle infarction, and occlusive arterial disease with stroke. Etiological factors (arterial hypertension, high plasma cholesterol, smoking, stress, diabetes) are similar, as are preventive measures (removal or control of etiological factors), and certain treatments (when the symptoms indicate angioplasty or without surgery) . Natural disposal of the body with blood vessel growth is a new approach. The treatment of angiogenesis has been through the use of angiogenic O: \ 65 \ 65722-910515.DOC \ 4 This paper size applies Chinese National Standard (CNS) A4 specifications (210X 297 mm) -45-

Binding

Line 567078 A7 _______B7 V. Explanation of the Invention (43) Growth factor attempt. Acid and basic fibroblast mother cells have been successfully tested in animal prototypes, but clear clinical results have not been reported in clinical trials. Vascular endothelial growth factor (VEGF) recombinant protein has been successfully tested in patients with myocardial infarction who are not ideal candidates for coronary arteries lacking cytoplasmic DnA for new blood vessels to increase supply and intramuscular injection. It represents 165 of VEGF Heteromorphism has been successfully tested in patients with severe local anemia. 1 Case 31: Young man with sequelae of anterior diaphragm acute myocardial infarction Patient number 32 is a 40-year-old man with sequelae of anterior diaphragm acute myocardial infarction. Patients were evaluated by clinical tests, blood tests, chest X-rays, electrocardiograms, compression tests, echocardiograms, coronary angiography, and cardiac X-ray photography. Observed injuries included local anemia with dilated anterior and lateral subepicardial membranes, and septal myocardial infarction before anterior left bifurcation block. A third 90% stenosis in the middle of the left anterior descending coronary artery will have the first diagonal in his origin. One of the arteries is severely narrowed, slow TIMI 2 flow, arteries, anterior, parietal, and adjoining motors are impaired. 20% of the sprayed part. Patients classified as functional class 3 of the New York Heart Association (NYHA) cannot be treated as coronary arteries and replaced with new blood vessels. The patient still needs to take I sorb ide 10 mg3, Aspirin 150 mg daily, and rest for an additional 4 months without showing any improvement. When the same medical treatment is continuously used as before, the electromagnetic force (EMFs) can then be applied to any of his arms for 3 months, 3 days a week, and 2 hours a day. After 1 month of electromagnetic force treatment, the patient's improvement will be very rapid, and even the adverse development of left descending coronary artery injury that changes from 90% stenosis to occlusion occurs. The clinical assessment and compression test classify the patient as New York Heart Association-46- O: \ 65 \ 65722-910515 D0C \ This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) 567078 A7 ___ B7 _ 5. Description of the invention (44) (NYtlA) functional level 1 to replace his previous level 3 〇 Anterior, top, lower, diagnosed by ventriculograin and echocardiogram, Lack of diaphragm function can improve hypokinesis. The contractility of collateral circulation and hyponating myocardial weakness can be improved. These changes can be explained by his medical treatment 4 months after the AMI and previous exposure to electromagnetic forces. At all times, the patient maintained functional level 3 (NYHA). The best explanation is that the patient's better clinical condition is only 1 month after the electromagnetic force exposure, and the functional level 1 (NYHA) can be improved in addition to the hypoperfusion myocardium induced by electromagnetic force stimulation of peripheral blood mononuclear white blood cells. Restored angiogenesis and vasculogenesis. Example 32 2: Obese women with arterial hypertension and sequelae of 3 months old acute myocardial infarction Patient 3 3 is one of arterial hypertension and sequelae pain suffered by 3 months old acute myocardial infarction (AMI) 54-year-old obese women. Patient assessments include clinical tests, blood tests, chest X-rays, electrocardiograms, compression tests, echocardiograms, coronary angiography, and ventriculography of the heart ventricle. Injuries include arterial hypertension, high glucose levels, uric acid, triglycerides, and cholesterol. Anterior diaphragm and lateral endocardial gangrene. Endometrial local anemia, right atrial enlargement, and coronary hemangioma before the expansion of the left descending coronary artery occlusion on his origin and 80% stenosis. Patients took 50 mg of Metoprolol every 12 hours, 10 mg of Isorbide, 20 mg of Pravacol every 24 hours, 2.5 mg of Norvas, and 100 mg of ASA. After 3 months, arterial hypertension and blood tests are within normal limits, but the worsening of cardiovascular signs is from functional grade 2 New York Heart Association (NYHA) to functional O: \ 65 \ 65722-910515DOC \ 4-47- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)

56707S A7 B7

• 48-Level 3 (NYHA). A stress test will attempt, but it will be postponed until the fatigue, hypertension, and pain test begins. Functional level 3 (νυηα). While continuing her previous treatment, the electromagnetic stimulation can then be applied to any of her arms for 5 months, 4 days a week, 2 hours a day. One month after the electromagnetic force treatment, the patient's assessment can be changed from functional grade 3 (NΥΗΑ) to functional grade jade (ΝΥΗΑ), and the collateral circulation and contractility of myocardial weakness can be improved. These changes can occur with more severe injuries than those observed in her previous coronary hemangioma. The coronary hemangioma line includes an additional occlusion of the right coronary artery in the third middle, and the first diagonal artery 90% stenosis and 5 mmHg left ventricular diastolic final pressure. These changes, which are only 1 month after the electromagnetic force, cannot be obtained through medical instructions during the 9 months after the AMI, and have been previously exposed to the electromagnetic force. In all of this coincidence, patients will progress from functional level 2 (NYHA) to successful moon level 3 (NYHA). The best description of the patient's best clinical condition, functional level 1 (nyha), provides restorable angiogenesis and angiogenesis in addition to hypoperfusion myocardium induced by electromagnetic forces that stimulate peripheral blood mononuclear leukocytes.

VI. Ankle Contusion I Patients included in this cohort have no other potential pain. This mural problem can be selected to evaluate the benefits of the electromagnetic force of the present invention in reducing pain and edema in a serious problem, and to observe whether the recovery of different types of internal injuries, which are fractures, can be accelerated. Phantom row 33: Ankle contusion type 8 patients of Zhang Bo A or B This example is to present information for a group of 8 patients (patients 3 4 to 4 1). These diseases O: \ 65 \ 65722-910515.DOC \ 4 This paper size applies to China National Standard (CNS) A4 specification (21 × 297 mm)

Binding

Line 567078 V. Description of the invention (46) The people are two women and six men, whose age is between "to" and "one or two feet ankle contusion type Weber AilB pain. All bruises are associated with intense pain and edema. All bruises are treated using internal coagulation. Compression of the two-sided wound can be obtained with appliances or wood screws without a semi-tubular compression plate. When instructed, surgical restoration of the deltoid ligament can be completed. Sterile dressing = applied to the injury, then a plaster fracture splint can keep the foot in the middle position and electromagnetic stimulation can then be started the day after the surgery On either arm of each patient. Keep your legs elevated, and your pain can be controlled daily with Dipiron 500,000. In all patients, pain can be reduced to 10 to 3 to 4 days. Edema can be reduced from 10 to 5-6 days, and bone engagement can be observed at 4 weeks instead of 6 weeks, at which time the patient allows the entire behavior. VIL lumbar muscle function is difficult. This patient can be selected as a nerve fiber regeneration paradigm that has not been treated for a disease. In terms of denervation, the axon and nerve endings that stimulate a muscle fiber degenerate. Sound denervated tissue can respond by releasing cytoplasmic movement, which causes terminal Schwann cells on denervated muscle fibers to stretch to a nerve ending treatment adjacent to the stimulating muscle fibers. Schwann cell processing then causes a nerve growth at the normal nerve endings, which can grow along with Schwann cell processing on the denervated endplate until the nerve transplantation on the denervated endplate is completed. In the early stages of a type of spinal muscular atrophy, when one of the spinal cord motor muscles dies, it is activated by electromagnetic force O: \ 65 \ 65722-910515.DOC \ This paper is suitable for financial standards @ 家 料 (CNS) A4 Specifications (plus X 297 public love) • 49- 567078 A7 ----- V. Description of the invention (47) One ----- The cytoplasmic stimulus message stimulated by PBMCs contains self-can-trigger nearby sound axons An event affected by a neurotransplantation disease that produces denervated muscle fibers. Example 34 4: Young boy with spinal muscular atrophy Patient 42 is a -4 year old boy with spinal muscular atrophy. Normal twin pregnancy discs A second boy giving birth, whose parents may favorably compare one twin to another. Their memory suggests that early development is delayed. He can start walking at Gu Yue ', but his footwork is abnormal, and since the age of two, he is no longer able to run or jump, it is not easy to walk one or two steps, and he often falls easily. Help your feet back. During the physical examination, the weakness of the flesh group is evident in all months, but especially in the shoulder and pelvic belt. Combined with tongue, electromyography, magnetic resonance imaging, and left quadriceps biopsy, these findings support the diagnosis of spinal muscular atrophy. During the last year, regular diet, rehabilitation therapy, and the use of stable artroses were not effective in improving his condition. After signing a voluntary consent form, the electromagnetic stimulation can then be applied to any of his arms for 1 month, 2 days a week, 2 hours a day, however, it will not be easy to achieve by his age. Therefore, a new design with Helmholtz coils can be used to expose part of the body while the child is sleeping. This mode of electromagnetic stimulation can be used for two years, 5 days a week, _2 hours a day. Through periodic inspections by the inventor, pediatricians, neurologists, restoration experts, mother and teacher notes, and videotapes can be used to track his development. After the first month, he will be better balanced and more confident to play with his brothers, sisters, and schoolmates. He started to gain weight, and at 4 months, he could walk without falling, and could start running and jumping. In O: \ 65 \ 65722-910515 DOC \ 4-50 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)

567078 A7

567078 A7 B7 V. Description of the invention (49) 134 Patient 230, 232 Power cord 136 Narrow bed 234 Transformer 150 Transfer box 236 Bridge regulator 152 Contact 238 Capacitor 154 Cable 240 Resistance 157 Coil 245 Narrow bed 159 Length Loop channel 250 Coil 160 Patient forearm 252 Tube wall 162 Patient upper arm 280 Saddle 200 Housing 282 Body part 204 Patient body part 288 Cable 214 Timer 290 Control unit 216 Control mechanism 292 Timer 218 Electronic panel 294 Control mechanism 224 Hz Holtz Coil 298 Coil O: \ 65 \ 65722-910515 DOC \ 5-52-This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)

Claims (1)

567078 Patent Application No. 0891173 04 Chinese Patent Application Replacement (October 1992) VI. Patent Application Garden A method for generating a time-varying electromagnetic field with a frequency of about 2 Hz to less than about 300 Hz and from about 2 μT A device with a static magnetic field component of approximately 0.8 mT, comprising: a housing having an inner and outer surface, a panel with an opening, and an elongated ring defined by the inner surface of the opening that can extend longitudinally from the opening A channel; and a magnetic coil arranged near the inner casing and the elongated annular channel to generate a time-varying electromagnetic field at a frequency of about 2 Hz to less than about 300 Hz in response to a current, and from about 2 μT to about 0 · 8 mT static magnetic field component. 2. 6. The device according to the scope of patent application, wherein the casing is rectangular. For example, the device in the scope of the patent application, wherein the shape of the casing is a square shape and the opening is circular. For example, the device of claim 3, wherein the casing is made of a non-magnetic material. For example, the device under the scope of patent application No. 4 wherein the non-magnetic material is selected from the group consisting of wood and plastic. For example, the device under the scope of patent application No. 4 further includes a timer and a control mechanism, and the channel is connected to an electronic panel to change and control the intensity and duration of the electromagnetic field generated by the magnetic coil. A device for simultaneously generating a fully time-varying electromagnetic field with a frequency of about 2 Hz to less than about 300 Hz and a static magnetic field component of from about 2 μT to about 0.8 mT. Elongated circular channel; and X 297 mm) This paper size applies to the Chinese national standard 567078 A8 B8 C8. A magnetic coil, which is applied for a patent, is arranged in the inner casing and near the elongated circular channel. Generates a time-varying electromagnetic field with a frequency of about 2 Hz to less than about 300 Hz and a static magnetic field component from about 2 μT to about 0.8 mT. 8. The device as claimed in claim 7 of the patent, wherein the casing is cylindrical. 9. The device according to item 8 of the scope of patent application, wherein the size of the casing can conform to the limb of the patient. 1 0. The device according to item 9 of the patent application, wherein the housing is made of a slightly non-magnetic material. 1 1 · The device according to the scope of the patent application, wherein the non-magnetic material is selected from the group consisting of wood and plastic. 12. The device of claim 10, further comprising an adapter box, the adapter box comprises a pair of contacts, which are connected to a power source, a transformer, a bridge regulator, and Two cables extend from the adapter box to supply current to the device's magnetic coil. 1 3 · A type to generate a time-varying electromagnetic field with a frequency of about 2 Hz to less than about 300 Hz, a static magnetic field component from about 2 μT to about 0.8 mT, and a voltage from about 40 mT to about 80 mT A device for static magnetic fields, which includes a housing having an inner and outer surface, a panel with an opening, and an elongated annular channel defined by an inner surface of the opening that can extend longitudinally from the opening; a pair of opposite and A parallel magnetic portion is arranged near the casing and the elongated annular channel to generate a static magnetic field; and a magnetic coil is installed inside the magnetic portion for generating a response to a current. Time-varying electromagnetic at a frequency of about 2 Hz to less than about 300 Hz -2-This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) Gutter 567078 Field, static magnetic field components from about 2 μT to about 0.8 mT, and—static magnetic fields from about 40 mT to about 80 mT. 1 4 · The device according to item 13 of the scope of patent application, wherein the outer shell is ~ momentary. 15 · The device according to item 13 of the scope of patent application, wherein the shape of the casing is like a square, and the opening is circular. 16 · The device according to item 4 of the patent application, wherein the casing is made of a non-magnetic material. 17. The device according to item 16 of the scope of patent application, wherein the non-magnetic material can be selected from the group consisting of wood and plastic. 18 · If the device in the scope of patent application No. 丨 6, further includes a timer and a control mechanism, the channel is connected to an electronic panel to change and control the strength and duration of the electromagnetic field generated by the magnetic coil time. 1 9 · A component to generate a time-varying electromagnetic field with a frequency of about 2 Hz to less than about 300 Hz, a static magnetic field component from about 2 μT to about 0.8 mT, and a static magnetic field from about 40 mT to about 80 mT Device comprising a circular shell having an internal diameter allowing a person to lie therebetween; a pair of opposing and parallel magnetic portions for generating a static magnetic field installed in the circular shell; and a magnetic The coil is installed inside the magnetic part for generating a time-varying electromagnetic field with a frequency of about 2 Hz to less than about 300 Hz in response to a current, a static magnetic field component from about 2 μT to about 0.8 mT, and a voltage from about 40 mT to a static magnetic field of about 80 mT. 2 0. The device according to item 9 of the patent application, wherein the casing is made of a non-magnetic material. -3- This paper size applies to China National Standard (CNS) A4 (210X297 mm) 6 5 K is the device in the scope of patent application, wherein the non-magnetic material can be selected from the group consisting of wood and plastic. 22. · If the device in the scope of application for patent No. 20, further includes a timer and a control mechanism, the channels are connected to an electronic panel to change and control the intensity and duration of the electromagnetic field generated by the magnetic coil. . 2 3 · A type for generating a time-varying electromagnetic field having a frequency of about 2 Hz to less than about 300 Hz, and a static magnetic field element of about 2 μT to about 0.8 mT includes a circular housing having The size of the internal diameter that allows a person to lie between them; and a magnetic coil 'which is installed inside the circular shell to generate a current that generates a time-varying electromagnetic field with a frequency of about 2 Hz to less than about 300 Hz And a static magnetic field component from about 2 μT to about 0.8 mT. 24. The device according to item 23 of the patent application, wherein the casing is made of a non-magnetic material. 25. The device according to item 24 of the scope of patent application, wherein the non-magnetic material can be selected from the group consisting of wood and plastic. 26. The device according to item 24 of the patent application, which further includes a timer and a control mechanism, and the channels are connected to an electronic panel for changing and controlling the intensity and duration of the electromagnetic field generated by the magnetic coil. 2 7 ·-A device for generating a static magnetic field component having a time-varying electromagnetic field with a frequency of about 2 Hz to less than about 300 Hz, from about 2 μT to about 0.8 mT, comprising a housing having A pair of opposite side walls, the side walls are separated enough for the size of this paper to apply the Chinese National Standard (CNS) A4 specification (210 X 297 mm) ---- ------ 567078 A8 B8 C8 ____ D8 6. Scope of patent application The ambassador can lie in between; and a pair of opposing and parallel Heniholtz magnetic coils, each coil being mounted on one of the opposing side walls, in response to a current, producing a frequency of about 2 Hz to less than A time-varying electromagnetic field with a frequency of about 300 Hz and a static magnetic field component from about 2 μT to about 0.8 mT. 28. The device of claim 27, wherein the casing is made of a non-magnetic material. 29. The device according to item 28 of the patent application, wherein the non-magnetic material can be selected from the group consisting of wood and plastic. 3 0 · The device in item 28 of the patent scope, which further includes a timer and a control mechanism, which are connected to the electronic panel to change and control the strength and duration of the electromagnetic field generated by the magnetic coil. time. 3 1 · —A device for generating a time-varying electromagnetic field with a frequency of about 2 Hz to less than about 300 Hz and a static magnetic field component from about 2 μT to about 0.8 mT, comprising 77 a saddle-shaped housing And a magnetic coil having a coil prepared in a saddle-shaped configuration, so that the coil can fit in the saddle-shaped housing to generate a current of about 2 Hz to less than about Time-varying electromagnetic% at 300 Hz and static magnetic field components from about 2 μT to about 0.8 mT. 3 2 · If the device in the scope of patent application No. 31 is made of materials. 3 3 · If the device in the scope of patent application No. 32 is selected from the group consisting of quality and plastic. The casing is made of a non-magnetic material which can be used by the non-magnetic material department from 567078 8 8 8 8 A BCD, and the scope of patent application is 34. If the device of the scope of patent application No. 32, further includes a timer and a Control mechanisms, channels, etc. are connected to the electronic panel to change and control the strength and duration of the electromagnetic field generated by the magnetic coils. -6- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)