RU2141966C1 - Антиандрогенные соединения, предшественник антиандрогенного соединения, фармацевтические композиции - Google Patents

Антиандрогенные соединения, предшественник антиандрогенного соединения, фармацевтические композиции Download PDF

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Publication number
RU2141966C1
RU2141966C1 RU94046463A RU94046463A RU2141966C1 RU 2141966 C1 RU2141966 C1 RU 2141966C1 RU 94046463 A RU94046463 A RU 94046463A RU 94046463 A RU94046463 A RU 94046463A RU 2141966 C1 RU2141966 C1 RU 2141966C1
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RU
Russia
Prior art keywords
mixture
mmol
antiandrogenic
hydroxy
androsten
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RU94046463A
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English (en)
Russian (ru)
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RU94046463A (ru
Inventor
Лабри Фернанд
Меранд Ив
М.Сингх Шанкар
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Андорешерш Инк.
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Application filed by Андорешерш Инк. filed Critical Андорешерш Инк.
Publication of RU94046463A publication Critical patent/RU94046463A/ru
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Publication of RU2141966C1 publication Critical patent/RU2141966C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0044—Alkenyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
RU94046463A 1993-05-17 1993-05-20 Антиандрогенные соединения, предшественник антиандрогенного соединения, фармацевтические композиции RU2141966C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6061293A 1993-05-17 1993-05-17
US08/060,612 1993-05-17
PCT/CA1993/000216 WO1994026767A1 (en) 1993-05-17 1993-05-20 Improved antiandrogens

Publications (2)

Publication Number Publication Date
RU94046463A RU94046463A (ru) 1997-02-27
RU2141966C1 true RU2141966C1 (ru) 1999-11-27

Family

ID=22030624

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94046463A RU2141966C1 (ru) 1993-05-17 1993-05-20 Антиандрогенные соединения, предшественник антиандрогенного соединения, фармацевтические композиции

Country Status (14)

Country Link
EP (1) EP0650495B1 (enExample)
JP (1) JP2741286B2 (enExample)
KR (1) KR100241228B1 (enExample)
AT (1) ATE197458T1 (enExample)
CA (1) CA2136303A1 (enExample)
CZ (2) CZ285893B6 (enExample)
DE (1) DE69329649D1 (enExample)
FI (1) FI945458A7 (enExample)
HU (1) HUT69408A (enExample)
PL (1) PL307333A1 (enExample)
RU (1) RU2141966C1 (enExample)
SK (1) SK139194A3 (enExample)
TW (1) TW259791B (enExample)
WO (1) WO1994026767A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879711A (en) * 1997-11-07 1999-03-09 Sequeira; Joel A. Stable antiandrogenic gel composition
CN1429104A (zh) 1998-03-11 2003-07-09 内部研究股份有限公司 5型和3型17β－羟基类固醇脱氢酶的抑制剂及其用法
WO2002089802A2 (en) 2001-05-08 2002-11-14 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
CN1551878B (zh) 2001-09-06 2011-08-10 先灵公司 用于治疗雄激素依赖性疾病的3型17β-羟基类固醇脱氢酶抑制剂
AR036812A1 (es) 2001-10-17 2004-10-06 Schering Corp Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de medicamentos para el tratamiento de enfermedades androgeno-dependientes
US7605152B2 (en) * 2002-01-15 2009-10-20 Merck & Co., Inc. 17-hydroxy-4-aza-androstan-3-ones as androgen receptor modulators
PE20040750A1 (es) 2002-11-18 2004-11-06 Schering Corp Derivados de n-(1-acetilpiperidin-4-il)-4-benzidril-2-isopropilpiperazin-1-carboxamida como inhibidores de 17beta-hidroxiesteroide deshidrogenasa de tipo 3
US7053091B2 (en) 2002-12-17 2006-05-30 Schering Corporation 17 β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
GB0513702D0 (en) 2005-07-04 2005-08-10 Sterix Ltd Compound
GB0722779D0 (en) 2007-11-20 2008-01-02 Sterix Ltd Compound

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1081494A (en) * 1965-09-14 1967-08-31 British Drug Houses Ltd 17ª‡-(alka-1',3'-diynyl)-steroids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3875188A (en) * 1968-04-10 1975-04-01 Eugene E Galantay 17-Beta-alpha-lower alkyl allene-substituted steroids
FR2430952A1 (fr) * 1978-07-13 1980-02-08 Roussel Uclaf Nouveaux derives acetyleniques de l'androst 4-ene, leur procede de preparation et leur application comme medicament
JPS5513273A (en) * 1978-07-13 1980-01-30 Kanebo Ltd Readily absorbable thiazolidine prodrug of anti- inflammatory corticosteroid and its drug composition
WO1991000732A1 (en) * 1989-07-07 1991-01-24 Endorecherche Inc. Androgen derivatives for use in the inhibition of sex steroid activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1081494A (en) * 1965-09-14 1967-08-31 British Drug Houses Ltd 17ª‡-(alka-1',3'-diynyl)-steroids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Машковский М.Д. Лекарственные средства. - М.: Медицина, 1993, т. 2, с. 550 - 552. *

Also Published As

Publication number Publication date
EP0650495B1 (en) 2000-11-08
FI945458L (fi) 1995-01-16
EP0650495A1 (en) 1995-05-03
CZ282494A3 (en) 1995-12-13
WO1994026767A1 (en) 1994-11-24
FI945458A0 (fi) 1994-11-21
TW259791B (enExample) 1995-10-11
FI945458A7 (fi) 1995-01-16
PL307333A1 (en) 1995-05-15
SK139194A3 (en) 1995-07-11
CA2136303A1 (en) 1994-11-24
CZ287991B6 (cs) 2001-03-14
RU94046463A (ru) 1997-02-27
CZ285893B6 (cs) 1999-11-17
KR100241228B1 (ko) 2000-02-01
HUT69408A (en) 1995-09-28
JPH08510988A (ja) 1996-11-19
JP2741286B2 (ja) 1998-04-15
DE69329649D1 (de) 2000-12-14
ATE197458T1 (de) 2000-11-11

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