RU2122540C1 - Бифенилзамещенные производные хинолина, фармацевтическая композиция, способ ингибирования - Google Patents

Бифенилзамещенные производные хинолина, фармацевтическая композиция, способ ингибирования Download PDF

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Publication number
RU2122540C1
RU2122540C1 RU93004569A RU93004569A RU2122540C1 RU 2122540 C1 RU2122540 C1 RU 2122540C1 RU 93004569 A RU93004569 A RU 93004569A RU 93004569 A RU93004569 A RU 93004569A RU 2122540 C1 RU2122540 C1 RU 2122540C1
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RU
Russia
Prior art keywords
biphenyl
tetrazol
oxy
pharmaceutically acceptable
acceptable salt
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RU93004569A
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English (en)
Russian (ru)
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RU93004569A (ru
Inventor
Эван Рионо Денис
Ллойд Джон
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Е.Р.Сквибб энд Санз, Инк.
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Application filed by Е.Р.Сквибб энд Санз, Инк. filed Critical Е.Р.Сквибб энд Санз, Инк.
Publication of RU93004569A publication Critical patent/RU93004569A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU93004569A 1992-02-14 1993-02-12 Бифенилзамещенные производные хинолина, фармацевтическая композиция, способ ингибирования RU2122540C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83778292A 1992-02-14 1992-02-14
US837,782 1992-02-14

Publications (2)

Publication Number Publication Date
RU93004569A RU93004569A (ru) 1996-01-10
RU2122540C1 true RU2122540C1 (ru) 1998-11-27

Family

ID=25275409

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93004569A RU2122540C1 (ru) 1992-02-14 1993-02-12 Бифенилзамещенные производные хинолина, фармацевтическая композиция, способ ингибирования

Country Status (16)

Country Link
EP (1) EP0556060A1 (OSRAM)
JP (1) JPH05286939A (OSRAM)
KR (1) KR930017891A (OSRAM)
CN (1) CN1044243C (OSRAM)
AU (1) AU656454B2 (OSRAM)
CA (1) CA2089185A1 (OSRAM)
FI (1) FI930621A7 (OSRAM)
HU (1) HU217627B (OSRAM)
IL (1) IL104623A (OSRAM)
MX (1) MX9300742A (OSRAM)
NO (1) NO930520L (OSRAM)
NZ (1) NZ245757A (OSRAM)
PL (1) PL172241B1 (OSRAM)
RU (1) RU2122540C1 (OSRAM)
TW (1) TW297025B (OSRAM)
ZA (1) ZA93531B (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2201753C1 (ru) * 2002-03-12 2003-04-10 Нестерук Владимир Викторович Фармацевтическая композиция, обладающая диуретическим, дегидратирующим и гипотензивным действием
RU2330841C2 (ru) * 2003-02-14 2008-08-10 Тереванс, Инк. Производные бифенила
RU2381223C2 (ru) * 2004-08-16 2010-02-10 Тереванс, Инк. Кристаллическая форма бифенильного соединения

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5767129A (en) * 1995-08-24 1998-06-16 Warner-Lambert Company Substituted quinolines and isoquinolines as calcium channel blockers, their preparation and the use thereof
US6455554B1 (en) 1999-06-07 2002-09-24 Targacept, Inc. Oxopyridinyl pharmaceutical compositions and methods for use
ES2274005T3 (es) 2001-01-26 2007-05-16 Chugai Seiyaku Kabushiki Kaisha Inhibidores de malonyl-coa decarboxilasa usados como moduladores metabolicos.
JP4503232B2 (ja) 2001-01-26 2010-07-14 中外製薬株式会社 マロニル−ＣｏＡ脱炭酸酵素阻害剤を用いた疾患の治療法
CA2735267C (en) 2001-01-26 2013-05-07 Chugai Seiyaku Kabushiki Kaisha Malonyl-coa decarboxylase inhibitors useful as metabolic modulators
ES2330417T3 (es) 2001-02-20 2009-12-10 Chugai Seiyaku Kabushiki Kaisha Procedimientos para tratar enfermedades metabolicas usando inhibidores de malonil coa descarboxilasa.
US7709510B2 (en) 2001-02-20 2010-05-04 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
WO2005011670A1 (en) 2003-08-01 2005-02-10 Chugai Seiyaku Kabushiki Kaisha Heterocyclic compounds useful as malonyl-coa decarboxylase inhibitors
CA2533749C (en) 2003-08-01 2012-07-10 Chugai Seiyaku Kabushiki Kaisha Piperidine compounds useful as malonyl-coa decarboxylase inhibitors
EP2208495B1 (en) 2003-08-01 2011-12-14 Chugai Seiyaku Kabushiki Kaisha Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors
EP1648564B1 (en) 2003-08-01 2007-10-17 Chugai Seiyaku Kabushiki Kaisha Cyanoamide compounds useful as malonyl-coa decarboxylase inhibitors
PT1928457E (pt) 2005-09-30 2013-02-19 Pulmagen Therapeutics Asthma Ltd Quinolinas e sua utilização terapêutica
GB0519969D0 (en) * 2005-09-30 2005-11-09 Argenta Discovery Ltd Quinoline compounds
EA017093B1 (ru) * 2007-04-04 2012-09-28 Пульмаджен Терапьютикс (Эсме) Лимитед Хинолины и их терапевтическое применение

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5049565A (en) * 1990-12-07 1991-09-17 Merck & Co., Inc. Microbial transformation process for preparing anti-hypertensive products

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE903911A1 (en) * 1989-11-20 1991-05-22 Ici Plc Diazine derivatives
GB9102727D0 (en) * 1991-02-08 1991-03-27 Ici Plc Pharmaceutical agent
US5157040A (en) * 1991-04-05 1992-10-20 Merck & Co., Inc. Substituted quinolines as angiotensin ii antagonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5049565A (en) * 1990-12-07 1991-09-17 Merck & Co., Inc. Microbial transformation process for preparing anti-hypertensive products

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
М.Д.Машковский "Лекарственные средства", ч.1, М., Медицина, 1988, с.127-129, 382-383. *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2201753C1 (ru) * 2002-03-12 2003-04-10 Нестерук Владимир Викторович Фармацевтическая композиция, обладающая диуретическим, дегидратирующим и гипотензивным действием
RU2330841C2 (ru) * 2003-02-14 2008-08-10 Тереванс, Инк. Производные бифенила
RU2381223C2 (ru) * 2004-08-16 2010-02-10 Тереванс, Инк. Кристаллическая форма бифенильного соединения

Also Published As

Publication number Publication date
JPH05286939A (ja) 1993-11-02
FI930621A0 (fi) 1993-02-12
PL297713A1 (en) 1993-08-23
CN1075720A (zh) 1993-09-01
EP0556060A1 (en) 1993-08-18
PL172241B1 (pl) 1997-08-29
HU217627B (hu) 2000-03-28
AU3299193A (en) 1993-08-19
CA2089185A1 (en) 1993-08-15
CN1044243C (zh) 1999-07-21
NO930520L (no) 1993-08-16
KR930017891A (ko) 1993-09-20
IL104623A0 (en) 1993-06-10
TW297025B (OSRAM) 1997-02-01
MX9300742A (es) 1993-09-01
ZA93531B (en) 1993-08-26
IL104623A (en) 1996-12-05
NO930520D0 (no) 1993-02-12
FI930621A7 (fi) 1993-08-15
HU9300386D0 (en) 1993-04-28
HUT69694A (en) 1995-09-28
AU656454B2 (en) 1995-02-02
NZ245757A (en) 1995-09-26

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20040213