RU2119922C1 - Производные пептидов или их фармацевтически приемлемые соли, способ их получения, фармацевтическая композиция и способ ингибирования действия тахикинина - Google Patents

Производные пептидов или их фармацевтически приемлемые соли, способ их получения, фармацевтическая композиция и способ ингибирования действия тахикинина Download PDF

Info

Publication number
RU2119922C1
RU2119922C1 RU94045881A RU94045881A RU2119922C1 RU 2119922 C1 RU2119922 C1 RU 2119922C1 RU 94045881 A RU94045881 A RU 94045881A RU 94045881 A RU94045881 A RU 94045881A RU 2119922 C1 RU2119922 C1 RU 2119922C1
Authority
RU
Russia
Prior art keywords
multiplet
compound
alkyl
formula
singlet
Prior art date
Application number
RU94045881A
Other languages
English (en)
Russian (ru)
Other versions
RU94045881A (ru
Inventor
Матсуо Масааки
Хагивара Дайджиро
Мийаке Хироси
Original Assignee
Фудзисава Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фудзисава Фармасьютикал Ко., Лтд. filed Critical Фудзисава Фармасьютикал Ко., Лтд.
Publication of RU94045881A publication Critical patent/RU94045881A/ru
Application granted granted Critical
Publication of RU2119922C1 publication Critical patent/RU2119922C1/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
RU94045881A 1992-04-21 1993-04-09 Производные пептидов или их фармацевтически приемлемые соли, способ их получения, фармацевтическая композиция и способ ингибирования действия тахикинина RU2119922C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/871,723 1992-04-21
US07/871723 1992-04-21
US07/871,723 US5420297A (en) 1990-10-24 1992-04-21 Peptides having substance P antagonistic activity

Publications (2)

Publication Number Publication Date
RU94045881A RU94045881A (ru) 1996-09-10
RU2119922C1 true RU2119922C1 (ru) 1998-10-10

Family

ID=25357987

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94045881A RU2119922C1 (ru) 1992-04-21 1993-04-09 Производные пептидов или их фармацевтически приемлемые соли, способ их получения, фармацевтическая композиция и способ ингибирования действия тахикинина

Country Status (17)

Country Link
US (2) US5420297A (enExample)
EP (1) EP0640099B1 (enExample)
JP (1) JPH07505879A (enExample)
KR (1) KR100250921B1 (enExample)
CN (1) CN1041830C (enExample)
AT (1) ATE205852T1 (enExample)
AU (1) AU674512B2 (enExample)
CA (1) CA2118503A1 (enExample)
DE (1) DE69330788T2 (enExample)
ES (1) ES2160103T3 (enExample)
HU (2) HUT71397A (enExample)
IL (1) IL105404A (enExample)
MX (1) MX9302178A (enExample)
RU (1) RU2119922C1 (enExample)
TW (1) TW314525B (enExample)
WO (1) WO1993021215A1 (enExample)
ZA (1) ZA932728B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007065450A1 (en) * 2005-12-07 2007-06-14 Leonid Andreevich Kozhemyakin Means for preventing and treating conjunctivitis of different ethiology (variants) and a method for the use thereof

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654400A (en) * 1991-10-04 1997-08-05 Fujisawa Pharmaceutical Co., Ltd. Process for making peptide compounds having tachykinin antagonistic activity
WO1994020126A1 (en) * 1993-03-03 1994-09-15 Fujisawa Pharmaceutical Co., Ltd. Use of peptides for the manufacture of a medicament
WO1995000536A1 (en) * 1993-06-22 1995-01-05 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds
KR100344607B1 (ko) * 1994-03-17 2002-11-20 후지레비오 가부시끼가이샤 아자펩티드유도체
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
EP0966958A4 (en) * 1997-03-14 2001-10-10 Fujisawa Pharmaceutical Co AEROSOL PREPARATION
US6251919B1 (en) 1998-02-27 2001-06-26 Warner-Lambert Heterocyclic substituted aniline calcium channel blockers
US6166052A (en) 1998-03-11 2000-12-26 Warner-Lambert Company Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers
US6399629B1 (en) 1998-06-01 2002-06-04 Microcide Pharmaceuticals, Inc. Efflux pump inhibitors
AU7311100A (en) * 1999-09-14 2001-04-17 Fujisawa Pharmaceutical Co., Ltd. Novel processes for the production of peptide compounds
US6437093B1 (en) * 2000-11-28 2002-08-20 Milkhaus Laboratory, Inc. Methods of treatment comprising administration of Substance P
GB0223077D0 (en) * 2002-10-04 2002-11-13 Univ Reading The Treatment of vascular diseases
TW200500341A (en) * 2002-11-12 2005-01-01 Astrazeneca Ab Novel compounds
US8017781B2 (en) * 2005-11-15 2011-09-13 Vertex Pharmaceuticals Incorporated Azaindazoles useful as inhibitors of kinases
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
DE202011000090U1 (de) 2011-01-14 2011-04-21 E-LEAD ELECTRONIC CO., LTD., Shengang Shiang Fahrzeug-Audiosystem mit auswechselbarem Plug-In-Computer
IT1403659B1 (it) * 2011-01-28 2013-10-31 Kerakoll S P A Stucco epossidico a base acquosa
EP2729147B1 (en) 2011-07-04 2017-09-06 IRBM - Science Park S.p.A. Nk-1 receptor antagonists for treating corneal neovascularisation
EP2757924B1 (en) * 2011-09-24 2016-12-28 EnE Holdings Ltd Beverage system with aeration
WO2019162519A1 (en) 2018-02-26 2019-08-29 Ospedale San Raffaele S.R.L. Nk-1 antagonists for use in the treatment of ocular pain
US20230134843A1 (en) 2020-03-11 2023-05-04 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187156A (en) * 1988-03-16 1993-02-16 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same
US5164372A (en) * 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
GB8929070D0 (en) * 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
EP0515681A4 (en) * 1990-02-15 1993-12-29 Fujisawa Pharmaceutical Co., Ltd. Peptide compound
GB9023116D0 (en) * 1990-10-24 1990-12-05 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Шредер Э., Любке К. Пептиды. -М.: Мир, 1967, ч. 1, стр. 116. EP 0443132A, C 07 K 5/06, A 61 K 37/02, 1991. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007065450A1 (en) * 2005-12-07 2007-06-14 Leonid Andreevich Kozhemyakin Means for preventing and treating conjunctivitis of different ethiology (variants) and a method for the use thereof

Also Published As

Publication number Publication date
MX9302178A (es) 1994-06-30
HU9403062D0 (en) 1994-12-28
DE69330788D1 (de) 2001-10-25
AU3904593A (en) 1993-11-18
KR950700928A (ko) 1995-02-20
KR100250921B1 (ko) 2000-04-01
RU94045881A (ru) 1996-09-10
WO1993021215A1 (en) 1993-10-28
JPH07505879A (ja) 1995-06-29
EP0640099A1 (en) 1995-03-01
TW314525B (enExample) 1997-09-01
ZA932728B (en) 1993-10-28
ATE205852T1 (de) 2001-10-15
IL105404A0 (en) 1993-08-18
CN1083074A (zh) 1994-03-02
US5633232A (en) 1997-05-27
CA2118503A1 (en) 1993-10-28
HU211831A9 (en) 1995-12-28
IL105404A (en) 1999-11-30
AU674512B2 (en) 1997-01-02
ES2160103T3 (es) 2001-11-01
HUT71397A (en) 1995-11-28
US5420297A (en) 1995-05-30
DE69330788T2 (de) 2002-05-29
EP0640099B1 (en) 2001-09-19
CN1041830C (zh) 1999-01-27

Similar Documents

Publication Publication Date Title
RU2119922C1 (ru) Производные пептидов или их фармацевтически приемлемые соли, способ их получения, фармацевтическая композиция и способ ингибирования действия тахикинина
JP3206764B2 (ja) ペプチド化合物
CA2032864C (en) Peptide compounds, a process for preparation thereof and pharmaceutical composition comprising the same
JP2000511173A (ja) 一酸化窒素産生阻害剤としての新規なインドリルおよびベンゾフラニルカルボキサミド
IE911641A1 (en) Indole derivatives
NO172893B (no) Analogifremgangsmaate for fremstilling av nye terapeutisk aktive cefem-forbindelser
CA2033363A1 (en) Quinazoline derivatives and their preparation
US5654400A (en) Process for making peptide compounds having tachykinin antagonistic activity
WO1995000536A1 (en) Peptide compounds
JPH05202096A (ja) 新規ポリペプチド化合物およびその製造方法
JPH10182643A (ja) ピラゾロピリジンアデノシン拮抗剤
JPH09501149A (ja) ペプチド化合物
JPH0881494A (ja) 新規な化合物およびその製造法
JPWO2001019848A1 (ja) ペプチド化合物の新規製造法
JPH06306081A (ja) 新規セフェム化合物
JP2003206299A (ja) ペプチド化合物の新規製造法