DE69330788T2 - Peptide wirksam als tachykinin antagonisten - Google Patents

Peptide wirksam als tachykinin antagonisten

Info

Publication number
DE69330788T2
DE69330788T2 DE69330788T DE69330788T DE69330788T2 DE 69330788 T2 DE69330788 T2 DE 69330788T2 DE 69330788 T DE69330788 T DE 69330788T DE 69330788 T DE69330788 T DE 69330788T DE 69330788 T2 DE69330788 T2 DE 69330788T2
Authority
DE
Germany
Prior art keywords
compound
solution
salt
acid
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69330788T
Other languages
German (de)
English (en)
Other versions
DE69330788D1 (de
Inventor
Daijiro Hagiwara
Masaaki Matsuo
Hiroshi Miyake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE69330788D1 publication Critical patent/DE69330788D1/de
Application granted granted Critical
Publication of DE69330788T2 publication Critical patent/DE69330788T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
DE69330788T 1992-04-21 1993-04-09 Peptide wirksam als tachykinin antagonisten Expired - Fee Related DE69330788T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/871,723 US5420297A (en) 1990-10-24 1992-04-21 Peptides having substance P antagonistic activity
PCT/JP1993/000470 WO1993021215A1 (en) 1992-04-21 1993-04-09 Peptides having tachykinin antagonist activity

Publications (2)

Publication Number Publication Date
DE69330788D1 DE69330788D1 (de) 2001-10-25
DE69330788T2 true DE69330788T2 (de) 2002-05-29

Family

ID=25357987

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69330788T Expired - Fee Related DE69330788T2 (de) 1992-04-21 1993-04-09 Peptide wirksam als tachykinin antagonisten

Country Status (17)

Country Link
US (2) US5420297A (enExample)
EP (1) EP0640099B1 (enExample)
JP (1) JPH07505879A (enExample)
KR (1) KR100250921B1 (enExample)
CN (1) CN1041830C (enExample)
AT (1) ATE205852T1 (enExample)
AU (1) AU674512B2 (enExample)
CA (1) CA2118503A1 (enExample)
DE (1) DE69330788T2 (enExample)
ES (1) ES2160103T3 (enExample)
HU (2) HUT71397A (enExample)
IL (1) IL105404A (enExample)
MX (1) MX9302178A (enExample)
RU (1) RU2119922C1 (enExample)
TW (1) TW314525B (enExample)
WO (1) WO1993021215A1 (enExample)
ZA (1) ZA932728B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654400A (en) * 1991-10-04 1997-08-05 Fujisawa Pharmaceutical Co., Ltd. Process for making peptide compounds having tachykinin antagonistic activity
WO1994020126A1 (en) * 1993-03-03 1994-09-15 Fujisawa Pharmaceutical Co., Ltd. Use of peptides for the manufacture of a medicament
WO1995000536A1 (en) * 1993-06-22 1995-01-05 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds
EP0672678B1 (en) * 1994-03-17 2000-10-25 Fujirebio Inc. Azapeptide derivative
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
WO1998041191A1 (en) * 1997-03-14 1998-09-24 Fujisawa Pharmaceutical Co., Ltd. Aerosol preparation
AU1600599A (en) 1998-02-27 1999-09-15 Warner-Lambert Company Heterocyclic substituted aniline calcium channel blockers
US6166052A (en) * 1998-03-11 2000-12-26 Warner-Lambert Company Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers
US6399629B1 (en) 1998-06-01 2002-06-04 Microcide Pharmaceuticals, Inc. Efflux pump inhibitors
WO2001019848A1 (fr) * 1999-09-14 2001-03-22 Fujisawa Pharmaceutical Co., Ltd. Nouveaux procedes de production de composes peptidiques
US6437093B1 (en) * 2000-11-28 2002-08-20 Milkhaus Laboratory, Inc. Methods of treatment comprising administration of Substance P
GB0223077D0 (en) * 2002-10-04 2002-11-13 Univ Reading The Treatment of vascular diseases
TW200500341A (en) * 2002-11-12 2005-01-01 Astrazeneca Ab Novel compounds
AU2006315436A1 (en) 2005-11-15 2007-05-24 Vertex Pharmaceuticals Incorporated Azaindazoles useful as inhibitors of kinases
EA008737B1 (ru) * 2005-12-07 2007-08-31 Леонид Андреевич Кожемякин Средство для профилактики и лечения конъюнктивитов и кератитов различной этиологии (варианты), способ его применения
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
DE202011000090U1 (de) 2011-01-14 2011-04-21 E-LEAD ELECTRONIC CO., LTD., Shengang Shiang Fahrzeug-Audiosystem mit auswechselbarem Plug-In-Computer
IT1403659B1 (it) * 2011-01-28 2013-10-31 Kerakoll S P A Stucco epossidico a base acquosa
WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
AU2012311098B2 (en) * 2011-09-24 2014-06-12 Electrical And Electronics, Ltd. Beverage system with aeration
RU2020131446A (ru) 2018-02-26 2022-03-28 Оспедале Сан Раффаэле С.Р.Л. Антагонисты nk-1 для применения в лечении глазной боли
EP4117673A1 (en) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Treatment of stem cell deficiency

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187156A (en) * 1988-03-16 1993-02-16 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same
US5164372A (en) * 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
GB8929070D0 (en) * 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
EP0515681A4 (en) * 1990-02-15 1993-12-29 Fujisawa Pharmaceutical Co., Ltd. Peptide compound
GB9023116D0 (en) * 1990-10-24 1990-12-05 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
CN1041830C (zh) 1999-01-27
AU3904593A (en) 1993-11-18
AU674512B2 (en) 1997-01-02
CA2118503A1 (en) 1993-10-28
US5420297A (en) 1995-05-30
HUT71397A (en) 1995-11-28
ATE205852T1 (de) 2001-10-15
CN1083074A (zh) 1994-03-02
JPH07505879A (ja) 1995-06-29
TW314525B (enExample) 1997-09-01
MX9302178A (es) 1994-06-30
ZA932728B (en) 1993-10-28
ES2160103T3 (es) 2001-11-01
KR100250921B1 (ko) 2000-04-01
IL105404A (en) 1999-11-30
RU94045881A (ru) 1996-09-10
RU2119922C1 (ru) 1998-10-10
HU9403062D0 (en) 1994-12-28
KR950700928A (ko) 1995-02-20
DE69330788D1 (de) 2001-10-25
US5633232A (en) 1997-05-27
HU211831A9 (en) 1995-12-28
EP0640099B1 (en) 2001-09-19
IL105404A0 (en) 1993-08-18
EP0640099A1 (en) 1995-03-01
WO1993021215A1 (en) 1993-10-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee