RU2110993C1 - Синергетическая фармацевтическая комбинация, фармацевтическая композиция и способ лечения или профилактики вич-инфекций - Google Patents

Синергетическая фармацевтическая комбинация, фармацевтическая композиция и способ лечения или профилактики вич-инфекций Download PDF

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Publication number
RU2110993C1
RU2110993C1 RU93045710A RU93045710A RU2110993C1 RU 2110993 C1 RU2110993 C1 RU 2110993C1 RU 93045710 A RU93045710 A RU 93045710A RU 93045710 A RU93045710 A RU 93045710A RU 2110993 C1 RU2110993 C1 RU 2110993C1
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Russia
Prior art keywords
combination
hiv
components
fluorocytosine
treatment
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RU93045710A
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English (en)
Russian (ru)
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RU93045710A (ru
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Роберт Пейнтер Джордж
Аллен Фурман Филип
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Дзе Велкам Фаундейшн Лимитед
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
RU93045710A 1991-03-06 1992-03-05 Синергетическая фармацевтическая комбинация, фармацевтическая композиция и способ лечения или профилактики вич-инфекций RU2110993C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9104740.7 1991-03-06
GB919104740A GB9104740D0 (en) 1991-03-06 1991-03-06 Antiviral nucleoside combination
PCT/GB1992/000389 WO1992015309A1 (en) 1991-03-06 1992-03-05 Antiviral nucleoside combination

Publications (2)

Publication Number Publication Date
RU93045710A RU93045710A (ru) 1996-11-10
RU2110993C1 true RU2110993C1 (ru) 1998-05-20

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RU93045710A RU2110993C1 (ru) 1991-03-06 1992-03-05 Синергетическая фармацевтическая комбинация, фармацевтическая композиция и способ лечения или профилактики вич-инфекций

Country Status (25)

Country Link
US (2) US5234913A (enExample)
EP (1) EP0574457B1 (enExample)
JP (1) JP3442773B2 (enExample)
KR (1) KR100225986B1 (enExample)
AT (1) ATE185483T1 (enExample)
AU (1) AU668860B2 (enExample)
CA (1) CA2105487C (enExample)
CZ (1) CZ283185B6 (enExample)
DE (1) DE69230140T2 (enExample)
DK (1) DK0574457T3 (enExample)
ES (1) ES2138969T3 (enExample)
GB (1) GB9104740D0 (enExample)
GR (1) GR3032299T3 (enExample)
HU (1) HU219492B (enExample)
IE (1) IE920702A1 (enExample)
IL (1) IL101145A (enExample)
MY (1) MY108638A (enExample)
NZ (1) NZ241842A (enExample)
PT (1) PT100199B (enExample)
RU (1) RU2110993C1 (enExample)
SK (1) SK279767B6 (enExample)
TW (1) TW199861B (enExample)
UA (1) UA29429C2 (enExample)
WO (1) WO1992015309A1 (enExample)
ZA (1) ZA921660B (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA017763B1 (ru) * 2004-07-09 2013-03-29 Джилид Сайэнс, Инк. Фармацевтический вагинальный гель

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US6642245B1 (en) * 1990-02-01 2003-11-04 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5728575A (en) * 1990-02-01 1998-03-17 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5925643A (en) * 1990-12-05 1999-07-20 Emory University Enantiomerically pure β-D-dioxolane-nucleosides
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US6812233B1 (en) * 1991-03-06 2004-11-02 Emory University Therapeutic nucleosides
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
CZ285232B6 (cs) * 1991-05-16 1999-06-16 Glaxo Group Limited Protivirové směsi
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
US20020120130A1 (en) * 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
WO1995024904A1 (en) * 1994-03-16 1995-09-21 Tanox Biosystems, Inc. Synergistic inhibition of hiv-1 infection using a nucleoside reverse transcriptase inhibitor and anti-hiv-1 antibodies
IL115156A (en) * 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
MY115461A (en) * 1995-03-30 2003-06-30 Wellcome Found Synergistic combinations of zidovudine, 1592u89 and 3tc
EP0831852B1 (en) 1995-06-07 2006-11-29 Emory University Nucleosides with anti-hepatitis b virus activity
CA2258956A1 (en) * 1996-06-25 1997-12-31 Glaxo Group Limited Combinations comprising vx478, zidovudine, ftc and/or 3tc for use in the treatment of hiv
CA2262765A1 (en) * 1996-06-25 1997-12-31 Glaxo Group Limited Combinations comprising vx478, zidovudine and/or 1592u89 for use in the treatment of hiv
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
EA001920B1 (ru) 1997-03-19 2001-10-22 Эмори Юниверсити Синтез 1,3-оксаселеноланнуклеозидов, их активность против вируса иммунодефицита человека и против вируса гепатита-b
JP2001518899A (ja) 1997-04-07 2001-10-16 トライアングル ファーマシューティカルズ，インコーポレイティド 他の抗ウイルス剤との組合せにおけるｍｋｃ−４４２の使用
US6040434A (en) * 1997-12-01 2000-03-21 Inaba; Tadanobu Aldehyde oxidase inhibitors for treatment of aids
MXPA00012842A (es) * 1998-06-24 2004-06-22 Univ Emory Uso de 3'-azido-2',3'-didesoxiuridina en combinacion de drogas adicionales contra el vih para la manufactura de un medicamento para el tratamiento del vih.
EP1104415B1 (en) 1998-08-12 2004-11-10 Gilead Sciences, Inc. Method of manufacture of 1,3-oxathiolane nucleosides
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
EP1124562B1 (en) 1998-11-02 2005-01-19 Gilead Sciences, Inc. Combination therapy to treat hepatitis b virus
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
EP1389207B1 (en) 2001-03-01 2005-12-07 Gilead Sciences, Inc. Polymorphic and other crystalline forms of cis-ftc

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US5159067A (en) * 1987-01-28 1992-10-27 University Of Georgia Research Foundation Inc. 5'-Diphosphohexose nucleoside pharmaceutical compositions
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA017763B1 (ru) * 2004-07-09 2013-03-29 Джилид Сайэнс, Инк. Фармацевтический вагинальный гель

Also Published As

Publication number Publication date
EP0574457B1 (en) 1999-10-13
DE69230140T2 (de) 2000-04-06
SK279767B6 (sk) 1999-03-12
SK95193A3 (en) 1994-01-12
GB9104740D0 (en) 1991-04-17
UA29429C2 (uk) 2000-11-15
WO1992015309A1 (en) 1992-09-17
PT100199B (pt) 1999-06-30
JPH06506199A (ja) 1994-07-14
PT100199A (pt) 1993-07-30
EP0574457A1 (en) 1993-12-22
DE69230140D1 (de) 1999-11-18
AU1351292A (en) 1992-10-06
ATE185483T1 (de) 1999-10-15
JP3442773B2 (ja) 2003-09-02
MY108638A (en) 1996-10-31
TW199861B (enExample) 1993-02-11
DK0574457T3 (da) 2000-04-17
CA2105487C (en) 2002-09-24
NZ241842A (en) 1994-08-26
HK1004189A1 (en) 1998-11-20
US5234913A (en) 1993-08-10
HU9302496D0 (en) 1993-11-29
IL101145A0 (en) 1992-11-15
CZ283185B6 (cs) 1998-01-14
IL101145A (en) 1996-08-04
US6107288A (en) 2000-08-22
IE920702A1 (en) 1992-09-09
ZA921660B (en) 1993-09-06
CA2105487A1 (en) 1992-09-07
CZ183693A3 (en) 1994-06-15
HU219492B (hu) 2001-04-28
KR100225986B1 (ko) 1999-10-15
ES2138969T3 (es) 2000-02-01
GR3032299T3 (en) 2000-04-27
HUT72460A (en) 1996-04-29
AU668860B2 (en) 1996-05-23

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