DK0574457T3 - Antiviral nucleosidkombination - Google Patents

Antiviral nucleosidkombination

Info

Publication number
DK0574457T3
DK0574457T3 DK92905707T DK92905707T DK0574457T3 DK 0574457 T3 DK0574457 T3 DK 0574457T3 DK 92905707 T DK92905707 T DK 92905707T DK 92905707 T DK92905707 T DK 92905707T DK 0574457 T3 DK0574457 T3 DK 0574457T3
Authority
DK
Denmark
Prior art keywords
antiviral nucleoside
combinations
combination
nucleoside combination
antiviral
Prior art date
Application number
DK92905707T
Other languages
Danish (da)
English (en)
Inventor
George Robert Painter Iii
Phillip Allen Furman
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of DK0574457T3 publication Critical patent/DK0574457T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK92905707T 1991-03-06 1992-03-05 Antiviral nucleosidkombination DK0574457T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919104740A GB9104740D0 (en) 1991-03-06 1991-03-06 Antiviral nucleoside combination
PCT/GB1992/000389 WO1992015309A1 (en) 1991-03-06 1992-03-05 Antiviral nucleoside combination

Publications (1)

Publication Number Publication Date
DK0574457T3 true DK0574457T3 (da) 2000-04-17

Family

ID=10691101

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92905707T DK0574457T3 (da) 1991-03-06 1992-03-05 Antiviral nucleosidkombination

Country Status (25)

Country Link
US (2) US5234913A (enExample)
EP (1) EP0574457B1 (enExample)
JP (1) JP3442773B2 (enExample)
KR (1) KR100225986B1 (enExample)
AT (1) ATE185483T1 (enExample)
AU (1) AU668860B2 (enExample)
CA (1) CA2105487C (enExample)
CZ (1) CZ283185B6 (enExample)
DE (1) DE69230140T2 (enExample)
DK (1) DK0574457T3 (enExample)
ES (1) ES2138969T3 (enExample)
GB (1) GB9104740D0 (enExample)
GR (1) GR3032299T3 (enExample)
HU (1) HU219492B (enExample)
IE (1) IE920702A1 (enExample)
IL (1) IL101145A (enExample)
MY (1) MY108638A (enExample)
NZ (1) NZ241842A (enExample)
PT (1) PT100199B (enExample)
RU (1) RU2110993C1 (enExample)
SK (1) SK279767B6 (enExample)
TW (1) TW199861B (enExample)
UA (1) UA29429C2 (enExample)
WO (1) WO1992015309A1 (enExample)
ZA (1) ZA921660B (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6903224B2 (en) 1988-04-11 2005-06-07 Biochem Pharma Inc. Substituted 1,3-oxathiolanes
SE464168B (sv) * 1989-07-19 1991-03-18 Bo Fredrik Oeberg Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt)
US5914331A (en) * 1990-02-01 1999-06-22 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5827727A (en) * 1990-02-01 1998-10-27 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5925643A (en) * 1990-12-05 1999-07-20 Emory University Enantiomerically pure β-D-dioxolane-nucleosides
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
US6812233B1 (en) * 1991-03-06 2004-11-02 Emory University Therapeutic nucleosides
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
DK0513917T4 (da) * 1991-05-16 2001-06-25 Glaxo Group Ltd Antivirale kombinationer indeholdende nukleosidanaloger
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
US20020120130A1 (en) * 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
WO1995024904A1 (en) * 1994-03-16 1995-09-21 Tanox Biosystems, Inc. Synergistic inhibition of hiv-1 infection using a nucleoside reverse transcriptase inhibitor and anti-hiv-1 antibodies
IL115156A (en) * 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
MY115461A (en) * 1995-03-30 2003-06-30 Wellcome Found Synergistic combinations of zidovudine, 1592u89 and 3tc
ATE346651T1 (de) 1995-06-07 2006-12-15 Univ Emory Nucleoside mit anti-hepatitis b virus wirksamkeit
HUP9903098A3 (en) * 1996-06-25 2000-01-28 Glaxo Group Ltd Combination comprising vx478, zidovudine and/or 1592u89 and pharmaceutical composition containing them
EA001517B1 (ru) * 1996-06-25 2001-04-23 Глаксо Груп Лимитед Комбинации, содержащие vx478, зидовудин и 3tc, для применения при лечении вич
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
EA001920B1 (ru) 1997-03-19 2001-10-22 Эмори Юниверсити Синтез 1,3-оксаселеноланнуклеозидов, их активность против вируса иммунодефицита человека и против вируса гепатита-b
JP2001518899A (ja) 1997-04-07 2001-10-16 トライアングル ファーマシューティカルズ，インコーポレイティド 他の抗ウイルス剤との組合せにおけるｍｋｃ−４４２の使用
US6040434A (en) * 1997-12-01 2000-03-21 Inaba; Tadanobu Aldehyde oxidase inhibitors for treatment of aids
AU4716299A (en) * 1998-06-24 2000-01-10 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
CN1141305C (zh) 1998-08-12 2004-03-10 三角药物公司 生产1,3-氧硫戊环核苷的方法
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
EP1380303B1 (en) 1998-11-02 2008-09-17 Gilead Sciences, Inc. Combination therapy to treat hepatitis B virus
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
JP5105689B2 (ja) 2001-03-01 2012-12-26 ギリード・サイエンシズ・インコーポレーテッド 多形型および他の結晶型のシス−ｆｔｃ
UA93354C2 (ru) * 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Местный противовирусный препарат

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
MC1742A1 (fr) * 1985-03-16 1987-02-26 Wellcome Found Procede pour preparer un derive de 3'-azido-3'desoxythymigline et procede pour preparer une formulation pharmaceutique le contenant
US4874751A (en) * 1985-03-16 1989-10-17 Burroughs Wellcome Co. Antibacterial treatment
HU196607B (en) * 1985-05-15 1988-12-28 Wellcome Found Process for producing dideoxy-nucleosides and pharmaceutics comprising such compounds
ZA878877B (en) * 1986-11-29 1988-05-24 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Treatment of diseases caused by viruses
US5159067A (en) * 1987-01-28 1992-10-27 University Of Georgia Research Foundation Inc. 5'-Diphosphohexose nucleoside pharmaceutical compositions
US4837311A (en) * 1987-06-22 1989-06-06 Hoffman-La Roche Inc. Anti-retroviral compounds
US5041449A (en) * 1988-04-11 1991-08-20 Iaf Biochem International, Inc. 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
NZ228645A (en) * 1988-04-11 1991-09-25 Iaf Biochem Int 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
JPH04501854A (ja) * 1989-05-15 1992-04-02 アメリカ合衆国 肝炎の治療方法
US5071983A (en) * 1989-10-06 1991-12-10 Burroughs Wellcome Co. Therapeutic nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
IT1249019B (it) * 1990-06-28 1995-02-11 Lamberti S P A L Emulsione acquosa di resine filmogene per la finitura di pelli, cuoio e croste di pelle e relativo procedimento di applicazione
AU8864191A (en) * 1990-11-13 1992-06-11 Biochem Pharma Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
DK0513917T4 (da) * 1991-05-16 2001-06-25 Glaxo Group Ltd Antivirale kombinationer indeholdende nukleosidanaloger

Also Published As

Publication number Publication date
PT100199B (pt) 1999-06-30
EP0574457B1 (en) 1999-10-13
US5234913A (en) 1993-08-10
PT100199A (pt) 1993-07-30
HK1004189A1 (en) 1998-11-20
ATE185483T1 (de) 1999-10-15
SK95193A3 (en) 1994-01-12
MY108638A (en) 1996-10-31
AU1351292A (en) 1992-10-06
US6107288A (en) 2000-08-22
GR3032299T3 (en) 2000-04-27
HU219492B (hu) 2001-04-28
AU668860B2 (en) 1996-05-23
JP3442773B2 (ja) 2003-09-02
HU9302496D0 (en) 1993-11-29
CZ183693A3 (en) 1994-06-15
GB9104740D0 (en) 1991-04-17
RU2110993C1 (ru) 1998-05-20
WO1992015309A1 (en) 1992-09-17
DE69230140D1 (de) 1999-11-18
TW199861B (enExample) 1993-02-11
JPH06506199A (ja) 1994-07-14
UA29429C2 (uk) 2000-11-15
ZA921660B (en) 1993-09-06
IE920702A1 (en) 1992-09-09
HUT72460A (en) 1996-04-29
IL101145A (en) 1996-08-04
KR100225986B1 (ko) 1999-10-15
CA2105487A1 (en) 1992-09-07
NZ241842A (en) 1994-08-26
IL101145A0 (en) 1992-11-15
EP0574457A1 (en) 1993-12-22
CZ283185B6 (cs) 1998-01-14
ES2138969T3 (es) 2000-02-01
DE69230140T2 (de) 2000-04-06
SK279767B6 (sk) 1999-03-12
CA2105487C (en) 2002-09-24

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