RU2105773C1 - Способ получения стабильных в кислой среде производных бензимидазола - Google Patents

Способ получения стабильных в кислой среде производных бензимидазола Download PDF

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Publication number
RU2105773C1
RU2105773C1 RU94031478A RU94031478A RU2105773C1 RU 2105773 C1 RU2105773 C1 RU 2105773C1 RU 94031478 A RU94031478 A RU 94031478A RU 94031478 A RU94031478 A RU 94031478A RU 2105773 C1 RU2105773 C1 RU 2105773C1
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RU
Russia
Prior art keywords
group
cyclodextrin
solution
buffer
omeprazole
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Application number
RU94031478A
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English (en)
Russian (ru)
Other versions
RU94031478A (ru
Inventor
Сан Мин Донг
Ан Ум Ки
Соо Ким Йонг
Ук Парк Пьеонг
Original Assignee
Санкионг Индастриз Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Санкионг Индастриз Ко., Лтд. filed Critical Санкионг Индастриз Ко., Лтд.
Publication of RU94031478A publication Critical patent/RU94031478A/ru
Application granted granted Critical
Publication of RU2105773C1 publication Critical patent/RU2105773C1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU94031478A 1991-12-31 1992-12-30 Способ получения стабильных в кислой среде производных бензимидазола RU2105773C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR91-25847 1991-12-31
KR910025847 1991-12-31
PCT/KR1992/000083 WO1993013138A1 (en) 1991-12-31 1992-12-30 A method for preparing enteric-coated oral drugs containing acid-unstable compounds

Publications (2)

Publication Number Publication Date
RU94031478A RU94031478A (ru) 1996-01-20
RU2105773C1 true RU2105773C1 (ru) 1998-02-27

Family

ID=19327322

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94031478A RU2105773C1 (ru) 1991-12-31 1992-12-30 Способ получения стабильных в кислой среде производных бензимидазола

Country Status (15)

Country Link
US (1) US5399700A (enExample)
EP (1) EP0619825B1 (enExample)
JP (1) JP2662518B2 (enExample)
KR (1) KR960008231B1 (enExample)
CN (1) CN1033790C (enExample)
BR (1) BR9207000A (enExample)
CA (1) CA2127111C (enExample)
DE (1) DE69222950T2 (enExample)
EG (1) EG20115A (enExample)
ES (1) ES2111148T3 (enExample)
HU (1) HU217135B (enExample)
MX (1) MX9207676A (enExample)
RU (1) RU2105773C1 (enExample)
TW (1) TW224049B (enExample)
WO (1) WO1993013138A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2279276C2 (ru) * 2000-01-11 2006-07-10 Зе Курэйторз Оф Зе Юниверсити Оф Миссури Новые лекарственные формы замещенных бензимидазолов и способы их применения
RU2313343C2 (ru) * 2001-06-06 2007-12-27 Сипла Лимитед Комплекс включения s-омепразола (эсомепразола) с циклодекстрином

Families Citing this family (46)

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AU5780696A (en) * 1995-06-02 1996-12-18 Takeda Chemical Industries Ltd. Stabilized composition comprising an antiulcerative benzimid azole
AU745707B2 (en) * 1995-09-21 2002-03-28 Pharma Pass Llc novel composition containing an acid-labile omeprazole and process for its preparation
ATE286394T1 (de) * 1995-09-21 2005-01-15 Pharma Pass Ii Llc Ein säurelabile omeprazol enthaltende arzneizusammensetzung und verfahren zu deren herstellung
RU2161481C2 (ru) * 1995-09-21 2001-01-10 Фарма Пасс Ллс Новая композиция, содержащая кислотно-нестойкий омепразол, и способ ее получения
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
CA2282513C (en) * 1997-03-13 2007-09-18 Hexal Ag Stabilization of acid sensitive benzimidazoles with amino acid/cyclodextrin combinations
SI9700186B (sl) 1997-07-14 2006-10-31 Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
KR100281521B1 (ko) * 1998-03-31 2001-02-15 김종인 프라바스타틴나트륨이 함유된 약제 조성물
US6733778B1 (en) * 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
SI20624A (sl) * 1998-12-18 2002-02-28 Abbott Laboratories Formulacija divalproeks natrija za kontrolirano sproščanje
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6369087B1 (en) * 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6462237B1 (en) * 2001-06-14 2002-10-08 Usv Limited Cyclodextrin stabilized pharmaceutical compositions of bupropion hydrochloride
EP1467770A1 (en) * 2002-01-15 2004-10-20 ALTANA Pharma AG Pantoprazole cyclodextrin inclusion complexes
WO2003063840A2 (en) * 2002-01-25 2003-08-07 Santarus, Inc. Transmucosal delivery of proton pump inhibitors
WO2004066924A2 (en) * 2003-01-24 2004-08-12 Andrx Labs Llc Novel pharmaceutical formulation containing a proton pump inhibitor and an antacid
TWI367759B (en) * 2003-02-20 2012-07-11 Santarus Inc A novel formulation, omeprazole antacid complex-immediate release, for rapid and sustained suppression of gastric acid
WO2004099181A1 (en) * 2003-05-05 2004-11-18 Ranbaxy Laboratories Limited Barium salt of benzimidazole derivative
KR100473422B1 (ko) * 2003-06-12 2005-03-14 박원봉 렉틴 함유 천연물의 장용성 코팅용 조성물
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
AU2004257864A1 (en) * 2003-07-18 2005-01-27 Santarus, Inc. Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
CA2531564C (en) * 2003-07-18 2016-01-19 Santarus, Inc. Pharmaceutical composition for inhibiting acid secretion
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
KR20050105565A (ko) * 2004-04-30 2005-11-04 에스케이케미칼주식회사 저장안정성이 우수한 벤즈이미다졸 유도체 함유 포접복합체 및 이의 제조방법
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP1833469A2 (en) * 2005-01-03 2007-09-19 Lupin Ltd. Pharmaceutical composition of acid labile substances
US20100297226A1 (en) * 2006-06-01 2010-11-25 Dexcel Pharma Technologies Ltd. Multiple unit pharmaceutical formulation
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
US20100233259A1 (en) * 2008-12-12 2010-09-16 Pascal Grenier Dosage form of ropinirole
CN101744788B (zh) * 2010-01-24 2013-12-11 山东新时代药业有限公司 一种奥美拉唑的肠溶片剂及制备方法
ITMI20121264A1 (it) * 2012-07-19 2014-01-20 Recordati Ind Chimica E Farma Ceutica S P A Forma farmaceutica gastro-resistente a rilascio ritardato
US20170042806A1 (en) 2015-04-29 2017-02-16 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions

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GB2239020B (en) * 1989-10-24 1993-07-21 Kalamazoo Holdings Inc Norbixin adducts with water-soluble or water-dispersible proteins or branched-chain or cyclic polysaccharides

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GB1433823A (en) * 1972-06-19 1976-04-28 Goetaverken Angteknik Ab Furnace wall containing spaced parallel water tubes and blocks mounted thereon
GB2239020B (en) * 1989-10-24 1993-07-21 Kalamazoo Holdings Inc Norbixin adducts with water-soluble or water-dispersible proteins or branched-chain or cyclic polysaccharides

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2279276C2 (ru) * 2000-01-11 2006-07-10 Зе Курэйторз Оф Зе Юниверсити Оф Миссури Новые лекарственные формы замещенных бензимидазолов и способы их применения
RU2313343C2 (ru) * 2001-06-06 2007-12-27 Сипла Лимитед Комплекс включения s-омепразола (эсомепразола) с циклодекстрином

Also Published As

Publication number Publication date
KR930012016A (ko) 1993-07-20
BR9207000A (pt) 1995-11-28
JP2662518B2 (ja) 1997-10-15
CA2127111C (en) 1996-05-21
DE69222950T2 (de) 1998-05-28
CN1076124A (zh) 1993-09-15
EG20115A (en) 1997-07-31
EP0619825B1 (en) 1997-10-29
WO1993013138A1 (en) 1993-07-08
ES2111148T3 (es) 1998-03-01
CA2127111A1 (en) 1993-07-08
DE69222950D1 (de) 1997-12-04
EP0619825A1 (en) 1994-10-19
MX9207676A (es) 1993-06-01
HU217135B (hu) 1999-11-29
KR960008231B1 (ko) 1996-06-21
US5399700A (en) 1995-03-21
JPH07506088A (ja) 1995-07-06
TW224049B (enExample) 1994-05-21
HU9401666D0 (en) 1994-09-28
CN1033790C (zh) 1997-01-15
HUT70494A (en) 1995-10-30

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