ES2111148T3 - Metodo para preparar farmacos administrables por via oral con recubrimiento enterico que contienen compuestos inestables a los acidos. - Google Patents
Metodo para preparar farmacos administrables por via oral con recubrimiento enterico que contienen compuestos inestables a los acidos.Info
- Publication number
- ES2111148T3 ES2111148T3 ES93901497T ES93901497T ES2111148T3 ES 2111148 T3 ES2111148 T3 ES 2111148T3 ES 93901497 T ES93901497 T ES 93901497T ES 93901497 T ES93901497 T ES 93901497T ES 2111148 T3 ES2111148 T3 ES 2111148T3
- Authority
- ES
- Spain
- Prior art keywords
- composite
- acids
- enteric coating
- coating containing
- oral route
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nanotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
LA PRESENTE INVENCION ES RELATIVA A UN METODO PARA PREPARAR DROGAS ORALES ENTERICAS CUBIERTAS QUE CONTIENEN COMPUESTO ACIDO INESTABLE, EN PARTICULAR UNA DROGA ORAL ENTERICA CUBIERTA PREPARADA EN LA FORMA DE UNIDADES DE DOSIFICACION ACIDO ESTABLES COMO UNA INCLUSION COMPLEJA FORMADA REACCIONANDO DERIVADO DE BENZOIMIDAZOLO, COMPUESTO ACIDO INESTABLE, CON CICLODEXTRINA EN SOLUCION ALCALINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR910025847 | 1991-12-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2111148T3 true ES2111148T3 (es) | 1998-03-01 |
Family
ID=19327322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93901497T Expired - Lifetime ES2111148T3 (es) | 1991-12-31 | 1992-12-30 | Metodo para preparar farmacos administrables por via oral con recubrimiento enterico que contienen compuestos inestables a los acidos. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5399700A (es) |
EP (1) | EP0619825B1 (es) |
JP (1) | JP2662518B2 (es) |
KR (1) | KR960008231B1 (es) |
CN (1) | CN1033790C (es) |
BR (1) | BR9207000A (es) |
CA (1) | CA2127111C (es) |
DE (1) | DE69222950T2 (es) |
EG (1) | EG20115A (es) |
ES (1) | ES2111148T3 (es) |
HU (1) | HU217135B (es) |
MX (1) | MX9207676A (es) |
RU (1) | RU2105773C1 (es) |
TW (1) | TW224049B (es) |
WO (1) | WO1993013138A1 (es) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996038175A1 (en) * | 1995-06-02 | 1996-12-05 | Takeda Chemical Industries, Ltd. | Stabilized composition comprising an antiulcerative benzimidazole |
AU745707B2 (en) * | 1995-09-21 | 2002-03-28 | Pharma Pass Llc | novel composition containing an acid-labile omeprazole and process for its preparation |
AU6998796A (en) * | 1995-09-21 | 1997-04-28 | Pharma Pass Llc | Novel composition containing an acid-labile benzimidazole and process for its preparation |
US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
US6699885B2 (en) | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
US6645988B2 (en) | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
NZ337592A (en) * | 1997-03-13 | 2001-01-26 | Hexal Ag | Stabilization of acid sensitive benzimidazoles with amino/cyclodextrin combinations |
SI9700186B (sl) | 1997-07-14 | 2006-10-31 | Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. | Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin |
US6174548B1 (en) | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6096340A (en) * | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
KR100281521B1 (ko) * | 1998-03-31 | 2001-02-15 | 김종인 | 프라바스타틴나트륨이 함유된 약제 조성물 |
US6733778B1 (en) * | 1999-08-27 | 2004-05-11 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
DE69913197T2 (de) * | 1998-12-18 | 2004-09-02 | Abbott Laboratories, Abbott Park | Natriumhydrogendivalproat-formulierungen mit gesteuerter freigabe |
US6245913B1 (en) | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
GB2376231A (en) * | 2001-06-06 | 2002-12-11 | Cipla Ltd | Benzimidazole-cyclodextrin inclusion complex |
US6462237B1 (en) * | 2001-06-14 | 2002-10-08 | Usv Limited | Cyclodextrin stabilized pharmaceutical compositions of bupropion hydrochloride |
US20050171057A1 (en) * | 2002-01-15 | 2005-08-04 | Altana Pharma Ag | Pantoprazole cyclodextrin inclusion complexes |
EP1469839A2 (en) * | 2002-01-25 | 2004-10-27 | Santarus, Inc. | Transmucosal delivery of proton pump inhibitors |
US20040166162A1 (en) * | 2003-01-24 | 2004-08-26 | Robert Niecestro | Novel pharmaceutical formulation containing a proton pump inhibitor and an antacid |
JP2006518751A (ja) * | 2003-02-20 | 2006-08-17 | サンタラス インコーポレイティッド | 胃酸の急速かつ持続的な抑制のための新規製剤、オメプラゾール制酸剤複合体−即時放出物 |
US20070060556A1 (en) * | 2003-05-05 | 2007-03-15 | Yatendra Kumar | Barium salt of benzimidazole derivative |
KR100473422B1 (ko) * | 2003-06-12 | 2005-03-14 | 박원봉 | 렉틴 함유 천연물의 장용성 코팅용 조성물 |
US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US20050031700A1 (en) * | 2003-07-18 | 2005-02-10 | Sanatarus, Inc. | Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders |
WO2005007115A2 (en) * | 2003-07-18 | 2005-01-27 | Santarus, Inc. | Pharmaceutical composition for inhibiting acid secretion |
US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
KR20050105565A (ko) * | 2004-04-30 | 2005-11-04 | 에스케이케미칼주식회사 | 저장안정성이 우수한 벤즈이미다졸 유도체 함유 포접복합체 및 이의 제조방법 |
US8815916B2 (en) * | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8906940B2 (en) * | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
MX2007008141A (es) * | 2005-01-03 | 2007-12-10 | Lupin Ltd | Composicion farmaceutica de sustancias labiles en medio acido. |
CA2654402A1 (en) * | 2006-06-01 | 2007-12-06 | Adel Penhasi | Multiple unit pharmaceutical formulation |
US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
US20100233259A1 (en) * | 2008-12-12 | 2010-09-16 | Pascal Grenier | Dosage form of ropinirole |
ITMI20121264A1 (it) * | 2012-07-19 | 2014-01-20 | Recordati Ind Chimica E Farma Ceutica S P A | Forma farmaceutica gastro-resistente a rilascio ritardato |
US20170042806A1 (en) | 2015-04-29 | 2017-02-16 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2260536C3 (de) * | 1972-12-11 | 1975-07-10 | Fa. H. Trommsdorff, 5100 Aachen | MolekiileinschluBverbindungen aus einem Silberalkanolammin-Komplex und beta-Cycloheptaamylose, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
DE3427787A1 (de) * | 1984-07-27 | 1986-01-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Wirkstoffkomplexe von 5-methoxy-2((4-methoxy-3,5-dimethyl-2-pyridyl) methylsulfinyl)-1h-benzimidazol mit cyclodextrinen, deren herstellung und arzneimittel |
US5053240A (en) * | 1989-10-24 | 1991-10-01 | Kalamazoo Holdings, Inc. | Norbixin adducts with water-soluble or water-dispersible proteins or branched-chain or cyclic polysaccharides |
-
1992
- 1992-12-22 TW TW081110281A patent/TW224049B/zh not_active IP Right Cessation
- 1992-12-29 US US07/997,791 patent/US5399700A/en not_active Expired - Lifetime
- 1992-12-30 HU HU9401666A patent/HU217135B/hu unknown
- 1992-12-30 DE DE69222950T patent/DE69222950T2/de not_active Expired - Lifetime
- 1992-12-30 WO PCT/KR1992/000083 patent/WO1993013138A1/en active IP Right Grant
- 1992-12-30 ES ES93901497T patent/ES2111148T3/es not_active Expired - Lifetime
- 1992-12-30 JP JP5511564A patent/JP2662518B2/ja not_active Expired - Fee Related
- 1992-12-30 EG EG81292A patent/EG20115A/xx active
- 1992-12-30 RU RU94031478A patent/RU2105773C1/ru active
- 1992-12-30 CN CN92115345A patent/CN1033790C/zh not_active Expired - Fee Related
- 1992-12-30 EP EP93901497A patent/EP0619825B1/en not_active Expired - Lifetime
- 1992-12-30 CA CA002127111A patent/CA2127111C/en not_active Expired - Lifetime
- 1992-12-30 BR BR9207000A patent/BR9207000A/pt not_active Application Discontinuation
- 1992-12-31 MX MX9207676A patent/MX9207676A/es not_active IP Right Cessation
- 1992-12-31 KR KR1019920027146A patent/KR960008231B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MX9207676A (es) | 1993-06-01 |
CN1076124A (zh) | 1993-09-15 |
TW224049B (es) | 1994-05-21 |
KR960008231B1 (ko) | 1996-06-21 |
EG20115A (en) | 1997-07-31 |
EP0619825B1 (en) | 1997-10-29 |
CA2127111C (en) | 1996-05-21 |
DE69222950T2 (de) | 1998-05-28 |
CA2127111A1 (en) | 1993-07-08 |
HU9401666D0 (en) | 1994-09-28 |
KR930012016A (ko) | 1993-07-20 |
DE69222950D1 (de) | 1997-12-04 |
EP0619825A1 (en) | 1994-10-19 |
HU217135B (hu) | 1999-11-29 |
JP2662518B2 (ja) | 1997-10-15 |
WO1993013138A1 (en) | 1993-07-08 |
RU2105773C1 (ru) | 1998-02-27 |
BR9207000A (pt) | 1995-11-28 |
HUT70494A (en) | 1995-10-30 |
JPH07506088A (ja) | 1995-07-06 |
CN1033790C (zh) | 1997-01-15 |
US5399700A (en) | 1995-03-21 |
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