RU2104010C1 - Способ лечения гепатита, композиция, усиливающая ин виво инактивацию вируса гепатита с, препарат для лечения гепатита с - Google Patents

Способ лечения гепатита, композиция, усиливающая ин виво инактивацию вируса гепатита с, препарат для лечения гепатита с Download PDF

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RU2104010C1
RU2104010C1 RU94022480A RU94022480A RU2104010C1 RU 2104010 C1 RU2104010 C1 RU 2104010C1 RU 94022480 A RU94022480 A RU 94022480A RU 94022480 A RU94022480 A RU 94022480A RU 2104010 C1 RU2104010 C1 RU 2104010C1
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Russia
Prior art keywords
thymosin
interferon
amount
hepatitis
treatment
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RU94022480A
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Russian (ru)
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RU94022480A (ru
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Кретьен Поль
Мучник Мильтон
Е.Шерман Кеннет
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Альфа I биомедикалз, Инк.
Дзе Боард оф Говернорс оф Вайн Стейт Юниверсити
Юнайтед Стейтс оф Америка эз Репрезентед бай дзе Секретари оф дзе Армии
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2292Thymosin; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Beans For Foods Or Fodder (AREA)
RU94022480A 1991-09-13 1992-09-08 Способ лечения гепатита, композиция, усиливающая ин виво инактивацию вируса гепатита с, препарат для лечения гепатита с RU2104010C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75954491A 1991-09-13 1991-09-13
US759544 1991-09-13
US759,544 1991-09-13
PCT/US1992/007556 WO1993005806A1 (en) 1991-09-13 1992-09-08 Composition and method of treating hepatitis c

Publications (2)

Publication Number Publication Date
RU94022480A RU94022480A (ru) 1996-07-20
RU2104010C1 true RU2104010C1 (ru) 1998-02-10

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RU94022480A RU2104010C1 (ru) 1991-09-13 1992-09-08 Способ лечения гепатита, композиция, усиливающая ин виво инактивацию вируса гепатита с, препарат для лечения гепатита с

Country Status (22)

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US (3) US6001799A (cg-RX-API-DMAC7.html)
EP (1) EP0603305B1 (cg-RX-API-DMAC7.html)
JP (1) JP3228512B2 (cg-RX-API-DMAC7.html)
KR (1) KR100254082B1 (cg-RX-API-DMAC7.html)
AT (1) ATE152914T1 (cg-RX-API-DMAC7.html)
AU (1) AU667327B2 (cg-RX-API-DMAC7.html)
CA (1) CA2119006C (cg-RX-API-DMAC7.html)
CZ (1) CZ286827B6 (cg-RX-API-DMAC7.html)
DE (1) DE69219782T2 (cg-RX-API-DMAC7.html)
DK (1) DK0603305T3 (cg-RX-API-DMAC7.html)
ES (1) ES2103966T3 (cg-RX-API-DMAC7.html)
FI (1) FI107879B (cg-RX-API-DMAC7.html)
GR (1) GR3024025T3 (cg-RX-API-DMAC7.html)
HU (1) HU221006B1 (cg-RX-API-DMAC7.html)
MX (1) MX9205240A (cg-RX-API-DMAC7.html)
NO (1) NO941310D0 (cg-RX-API-DMAC7.html)
RO (1) RO111991B1 (cg-RX-API-DMAC7.html)
RU (1) RU2104010C1 (cg-RX-API-DMAC7.html)
SG (1) SG64897A1 (cg-RX-API-DMAC7.html)
TW (1) TW224053B (cg-RX-API-DMAC7.html)
WO (1) WO1993005806A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA926964B (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2211703C2 (ru) * 2001-06-08 2003-09-10 ООО НТЦ "Юпитер-2" Антистрессорное и ноотропное средство с антивирусным и иммуностимулирующим действием
WO2005021007A1 (fr) * 2003-08-28 2005-03-10 Obschestvo S Ogranichennoi Otvetstvennostju 'berezovy Mir' Prevention et traitement de l'hepatite virale b

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW224053B (cg-RX-API-DMAC7.html) * 1991-09-13 1994-05-21 Paul B Chretien
WO1995011688A1 (en) * 1992-02-06 1995-05-04 Sciclone Pharmaceuticals Method for treating hepatitis b carriers with minimal disease
AU751199B2 (en) * 1992-07-13 2002-08-08 Government Of The United States Of America As Represented By The Secretary Of The Army Composition and method of treating hepatitis B
WO1994001125A1 (en) * 1992-07-13 1994-01-20 Sherman Kenneth E Composition and method of treating hepatitis b
CN1072961C (zh) * 1993-03-05 2001-10-17 施塞克龙药品公司 治疗对干扰素治疗无反应者的丙型肝炎的方法
US6200952B1 (en) 1993-06-02 2001-03-13 Sciclone Pharmaceuticals, Inc. Combination therapy method for treating chronic hepatitis B
US5468729A (en) * 1993-10-26 1995-11-21 Alpha 1 Biomedicals Method for treatment of autoimmune hepatitis
EP0731710B1 (en) * 1993-11-05 2003-05-14 Alpha 1 Biomedicals, Inc. Thymosine alpha 1 containing compositions for the treatment of patients having decompensated liver disease
JP3837769B2 (ja) * 1995-06-12 2006-10-25 大塚製薬株式会社 抗ウイルス剤
GEP20012489B (en) * 1996-02-28 2001-07-25 Ifi Inst Farmacoterapico Italiano S P A Use of Natural Human α-Interferon
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
KR20080021797A (ko) 2000-05-26 2008-03-07 이데닉스(케이만)리미티드 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
EA007785B1 (ru) * 2000-08-07 2007-02-27 Сайклоун Фармасьютикалз, Инк. Способ лечения гепатита с с помощью тимозина, интерферона и рибавирина
US7208167B2 (en) * 2000-08-07 2007-04-24 Sciclone Pharmaceuticals, Inc. Treatment of hepatitis C with thymosin and peptide combination therapy
US6878364B2 (en) * 2000-12-01 2005-04-12 Cornell Research Foundation, Inc. Animal model for flaviviridae infection
WO2003026589A2 (en) * 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
WO2003030613A2 (en) * 2001-10-05 2003-04-17 Intermune, Inc. Methods of treating liver fibrosis and hepatitis c virus infection
DE60224435T2 (de) 2001-10-26 2009-01-02 Rhode Island Hospital Thymosin-augmentation bei genetischer immunisierung
UA80957C2 (en) * 2001-11-01 2007-11-26 Sciclone Pharmaceuticals Inc Method of administering a thymosin alpha 1 peptide
WO2003068162A2 (en) * 2002-02-14 2003-08-21 Pharmasset Ltd. Modified fluorinated nucleoside analogues
JP2005533817A (ja) 2002-06-28 2005-11-10 イデニクス(ケイマン)リミテツド フラビウィルス科ウィルス感染治療用の修飾2′および3′−ヌクレオシドプロドラッグ
JP2005533824A (ja) 2002-06-28 2005-11-10 イデニクス(ケイマン)リミテツド フラビウイルス科感染の治療のための2’−c−メチル−3’−o−l−バリンエステルリボフラノシルシチジン
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
EP1585529A4 (en) 2002-12-12 2008-05-28 Idenix Cayman Ltd PROCESS FOR PREPARING 2'-BRANCHED NUCLEOSIDES
GB0301879D0 (en) * 2003-01-27 2003-02-26 Regent Res Llp HCV combination therapy
JP4149296B2 (ja) * 2003-03-26 2008-09-10 株式会社ルネサステクノロジ 半導体記憶装置
DE602004027127D1 (de) * 2003-03-28 2010-06-24 Sciclone Pharmaceuticals Inc Behandlung von aspergillus-infektionen mit thymosin alpha 1
AU2004226403B2 (en) 2003-03-28 2008-12-04 Sciclone Pharmaceuticals, Inc. Treatment of aspergillus infections with thymosin alpha 1
US20100311656A1 (en) * 2003-04-23 2010-12-09 Sciclone Pharmaceuticals, Inc. Treatment or prevention of respiratory viral infections with alpha thymosin peptides
ES2586668T5 (es) 2003-05-30 2024-11-12 Gilead Pharmasset Llc Análogos de nucleósidos fluorados modificados
RU2006105640A (ru) 2003-07-25 2007-09-10 Айденикс (Кайман) Лимитед (Ky) Аналоги пуриновых нуклеозидов для лечения flaviviridae, включая гепатит с
CN1980657A (zh) 2004-05-05 2007-06-13 耶鲁大学 新颖的抗病毒赛菊宁黄质类似物
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
WO2006031725A2 (en) 2004-09-14 2006-03-23 Pharmasset, Inc. Preparation of 2'­fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
CA2634749C (en) 2005-12-23 2014-08-19 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
EP1832295A1 (en) * 2006-03-10 2007-09-12 Tecnogen S.P.A. Use of PTX3 for the treatment of viral diseases
AU2007247292B2 (en) * 2006-05-02 2012-04-05 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of thymosin alpha1, alone or in combination with PTX3 or Ganciclovir, for the treatment of cytomegalovirus infection
ES2288118B1 (es) * 2006-05-10 2008-11-01 Bcn Peptides, S.A. Procedimiento para sintetizar timosinas.
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
TW200946541A (en) * 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
WO2010042697A1 (en) * 2008-10-08 2010-04-15 University Of Miami Regulation of lymphocytes and uses therefor
EA019341B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Фосфорамидаты нуклеозидов
EP2376514A2 (en) 2008-12-23 2011-10-19 Pharmasset, Inc. Nucleoside analogs
BRPI0923815A2 (pt) 2008-12-23 2015-07-14 Pharmasset Inc Síntese de nucleosídeos de purina
JP2012526149A (ja) 2009-05-08 2012-10-25 サイクローン・ファーマシューティカルズ・インコーポレイテッド ワクチン増強剤としてのαチモシンペプチド
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
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PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
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US8841275B2 (en) 2010-11-30 2014-09-23 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US8809354B2 (en) 2011-12-31 2014-08-19 Sheikh Riazuddin 3-amino-2-(4-nitrophenyl)-4-(3H)-quinazolinone or derivatives thereof for treating or preventing antiviral infections
CN103800293B (zh) * 2012-11-09 2015-10-21 长春海悦药业有限公司 一种含有胸腺法新的药物组合物及其制剂
SI3038601T1 (sl) 2013-08-27 2020-07-31 Gilead Pharmasset Llc Formulacija kombinacije dveh protivirusnih spojin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0331934A1 (en) * 1988-03-11 1989-09-13 SCLAVO S.p.A. New pharmaceutical compositions containing thymosin alpha 1

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273963A (en) * 1991-03-29 1993-12-28 The George Washington University Compositions and methods for treating small cell and nonsmall cell lung cancers
TW224053B (cg-RX-API-DMAC7.html) * 1991-09-13 1994-05-21 Paul B Chretien

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0331934A1 (en) * 1988-03-11 1989-09-13 SCLAVO S.p.A. New pharmaceutical compositions containing thymosin alpha 1

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Di Bisceqlie A.M. et al.-New England of Medicine, 1989, N 10, p.321. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2211703C2 (ru) * 2001-06-08 2003-09-10 ООО НТЦ "Юпитер-2" Антистрессорное и ноотропное средство с антивирусным и иммуностимулирующим действием
WO2005021007A1 (fr) * 2003-08-28 2005-03-10 Obschestvo S Ogranichennoi Otvetstvennostju 'berezovy Mir' Prevention et traitement de l'hepatite virale b

Also Published As

Publication number Publication date
EP0603305B1 (en) 1997-05-14
RU94022480A (ru) 1996-07-20
MX9205240A (es) 1993-07-01
JPH06510998A (ja) 1994-12-08
HU9400758D0 (en) 1994-06-28
JP3228512B2 (ja) 2001-11-12
CA2119006A1 (en) 1993-04-01
CZ55194A3 (en) 1994-10-19
HK1021687A1 (en) 2000-06-23
FI941133A0 (fi) 1994-03-10
RO111991B1 (ro) 1997-04-30
DE69219782T2 (de) 1997-10-09
FI941133L (fi) 1994-03-10
ZA926964B (en) 1993-04-26
WO1993005806A1 (en) 1993-04-01
KR100254082B1 (ko) 2000-09-01
HUT75166A (en) 1997-04-28
AU667327B2 (en) 1996-03-21
GR3024025T3 (en) 1997-10-31
CZ286827B6 (cs) 2000-07-12
DK0603305T3 (da) 1997-09-01
US6001799A (en) 1999-12-14
SG64897A1 (en) 1999-05-25
CA2119006C (en) 2005-08-23
NO941310L (no) 1994-04-12
AU2644792A (en) 1993-04-27
DE69219782D1 (de) 1997-06-19
EP0603305A1 (en) 1994-06-29
ATE152914T1 (de) 1997-05-15
ES2103966T3 (es) 1997-10-01
TW224053B (cg-RX-API-DMAC7.html) 1994-05-21
US5849696A (en) 1998-12-15
NO941310D0 (no) 1994-04-12
FI107879B (fi) 2001-10-31
HU221006B1 (hu) 2002-07-29
US20070218033A1 (en) 2007-09-20

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