RU2072989C1 - Производные метиленоксиндола, способ их получения и фармацевтическая композиция - Google Patents
Производные метиленоксиндола, способ их получения и фармацевтическая композиция Download PDFInfo
- Publication number
- RU2072989C1 RU2072989C1 RU9293004893A RU93004893A RU2072989C1 RU 2072989 C1 RU2072989 C1 RU 2072989C1 RU 9293004893 A RU9293004893 A RU 9293004893A RU 93004893 A RU93004893 A RU 93004893A RU 2072989 C1 RU2072989 C1 RU 2072989C1
- Authority
- RU
- Russia
- Prior art keywords
- hydrogen
- indolyl
- methylene
- oxindole
- hydroxy
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 23
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919115160A GB9115160D0 (en) | 1991-07-12 | 1991-07-12 | Methylen-oxindole derivatives and process for their preparation |
| GB9115160.5 | 1991-07-12 | ||
| PCT/EP1992/001569 WO1993001182A1 (en) | 1991-07-12 | 1992-07-10 | Methylen-oxindole derivatives and process for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93004893A RU93004893A (ru) | 1996-12-20 |
| RU2072989C1 true RU2072989C1 (ru) | 1997-02-10 |
Family
ID=10698323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU9293004893A RU2072989C1 (ru) | 1991-07-12 | 1992-07-10 | Производные метиленоксиндола, способ их получения и фармацевтическая композиция |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5409949A (enExample) |
| EP (2) | EP0552329B1 (enExample) |
| JP (1) | JP3188701B2 (enExample) |
| KR (1) | KR930702337A (enExample) |
| AT (1) | ATE206420T1 (enExample) |
| AU (1) | AU656015B2 (enExample) |
| CA (1) | CA2091058C (enExample) |
| DE (1) | DE69232093T2 (enExample) |
| DK (1) | DK0552329T3 (enExample) |
| ES (1) | ES2165357T3 (enExample) |
| FI (1) | FI931061A0 (enExample) |
| GB (1) | GB9115160D0 (enExample) |
| HU (1) | HUT67496A (enExample) |
| IE (1) | IE922253A1 (enExample) |
| IL (1) | IL102383A (enExample) |
| MX (1) | MX9204008A (enExample) |
| NZ (1) | NZ243454A (enExample) |
| PT (1) | PT552329E (enExample) |
| RU (1) | RU2072989C1 (enExample) |
| TW (1) | TW202444B (enExample) |
| WO (1) | WO1993001182A1 (enExample) |
| ZA (1) | ZA925169B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2236231C2 (ru) * | 1998-06-15 | 2004-09-20 | Аста Медика Акциенгезельшафт | Таблетка циклофосфамида с пленочным покрытием (варианты) и способ ее получения, ядро таблетки и способ его получения |
| RU2527526C2 (ru) * | 2009-06-25 | 2014-09-10 | Эверест Байосайенсиз Инк. | Индолил-замещенные пиразино-хинолины и их применение для лечения рака |
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| GB9004483D0 (en) * | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
| US5587385A (en) * | 1991-12-24 | 1996-12-24 | Farmitalia Carlo Erba S.R.L. | Arylidene-heterocyclic derivatives and process for their preparation |
| GB9313638D0 (en) * | 1993-07-01 | 1993-08-18 | Erba Carlo Spa | Arylidene and heteroarylidene oxindole derivatives and process for their preparation |
| GB9326136D0 (en) * | 1993-12-22 | 1994-02-23 | Erba Carlo Spa | Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents |
| GB9406137D0 (en) * | 1994-03-28 | 1994-05-18 | Erba Carlo Spa | N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation |
| GB9412719D0 (en) * | 1994-06-24 | 1994-08-17 | Erba Carlo Spa | Substituted azaindolylidene compounds and process for their preparation |
| GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| GB9507298D0 (en) * | 1995-04-07 | 1995-05-31 | Pharmacia Spa | Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors |
| US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US6147106A (en) | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| GB9610964D0 (en) * | 1996-05-24 | 1996-07-31 | Pharmacia & Upjohn Spa | Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors |
| ES2251741T3 (es) * | 1996-08-23 | 2006-05-01 | Sugen, Inc. | Bibliotecas combinatorias de indolinona y productos afines y metodos para el tratamiento de enfermedades. |
| WO1998024432A2 (en) * | 1996-12-05 | 1998-06-11 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
| US6051597A (en) * | 1997-06-13 | 2000-04-18 | Merck & Co., Inc. | Indolylquinones as antidiabetic agents |
| US20040067531A1 (en) * | 1997-08-20 | 2004-04-08 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| WO2000008202A2 (en) * | 1998-08-04 | 2000-02-17 | Sugen, Inc. | 3-methylidenyl-2-indolinone modulators of protein kinase |
| US6531502B1 (en) | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
| JP2002504529A (ja) | 1998-02-27 | 2002-02-12 | ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンティッド バイ ザ シークレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 二置換ラベンダスティンａ類似体およびこれらの類似体を含む薬学的組成物 |
| US6102942A (en) | 1998-03-30 | 2000-08-15 | Endovascular Technologies, Inc. | Stent/graft deployment catheter with a stent/graft attachment mechanism |
| US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| US6680335B2 (en) | 1998-09-28 | 2004-01-20 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
| US6153634A (en) * | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
| JP2002532493A (ja) | 1998-12-17 | 2002-10-02 | エフ．ホフマン−ラ ロシュ アーゲー | Ｊｎｋプロテインキナーゼ阻害剤としての４−アリールオキシインドール |
| TR200101860T2 (tr) | 1998-12-17 | 2001-12-21 | F.Hoffmann-La Roche Ag | Sikline bağlı kinaz inhibitörleri olarak 4-alkenil (ve alkinil) oksidoller |
| EP1149105B1 (en) | 1998-12-17 | 2008-02-27 | F. Hoffmann-La Roche Ag | 4,5-pyrazinoxindoles as protein kinase inhibitors |
| JP2000247949A (ja) * | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
| US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6492398B1 (en) | 1999-03-04 | 2002-12-10 | Smithkline Beechman Corporation | Thiazoloindolinone compounds |
| US6689806B1 (en) | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| WO2000056709A1 (en) * | 1999-03-24 | 2000-09-28 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
| US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
| RU2240826C2 (ru) | 2000-02-03 | 2004-11-27 | Эйсай Ко., Лтд. | Ингибитор экспрессии интегрина |
| EP1255752B1 (en) | 2000-02-15 | 2007-08-08 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
| US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
| TWI270545B (en) | 2000-05-24 | 2007-01-11 | Sugen Inc | Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| JP2003535847A (ja) * | 2000-06-02 | 2003-12-02 | スージェン・インコーポレーテッド | 蛋白質キナーゼ／ホスファターゼ阻害剤としてのインドリノン誘導体 |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| AU2002303892A1 (en) | 2001-05-30 | 2002-12-09 | Jingrong Cui | 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors |
| AR038957A1 (es) * | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
| BR0213185A (pt) | 2001-10-10 | 2004-09-14 | Sugen Inc | Derivados de 3-[4-(heterociclila substituìda)-pirrol-2-ilmetilideno]2-indolinona como inibidores de cinase |
| JP4542783B2 (ja) * | 2002-03-05 | 2010-09-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有複素環化合物及び血管新生抑制剤とを組み合わせてなる抗腫瘍剤 |
| US20050107819A1 (en) * | 2003-11-14 | 2005-05-19 | Medtronic Vascular, Inc. | Catheter with a sectional guidewire shaft |
| US8772269B2 (en) * | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| CN103274988B (zh) * | 2013-06-20 | 2016-04-13 | 河北大学 | 3-(氰基-p-硝基苯甲撑基)-2-吲哚酮衍生物及其合成方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3310891A1 (de) * | 1983-03-25 | 1984-09-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
| JPH03213847A (ja) * | 1990-01-18 | 1991-09-19 | Konica Corp | ハロゲン化銀写真感光材料 |
| GB9004483D0 (en) * | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
-
1991
- 1991-07-12 GB GB919115160A patent/GB9115160D0/en active Pending
-
1992
- 1992-07-02 IL IL102383A patent/IL102383A/xx not_active IP Right Cessation
- 1992-07-06 NZ NZ243454A patent/NZ243454A/en unknown
- 1992-07-06 TW TW081105346A patent/TW202444B/zh active
- 1992-07-08 MX MX9204008A patent/MX9204008A/es not_active IP Right Cessation
- 1992-07-10 DK DK92914619T patent/DK0552329T3/da active
- 1992-07-10 ZA ZA925169A patent/ZA925169B/xx unknown
- 1992-07-10 US US07/987,280 patent/US5409949A/en not_active Expired - Lifetime
- 1992-07-10 AU AU22777/92A patent/AU656015B2/en not_active Ceased
- 1992-07-10 RU RU9293004893A patent/RU2072989C1/ru active
- 1992-07-10 HU HU9300723A patent/HUT67496A/hu unknown
- 1992-07-10 EP EP92914619A patent/EP0552329B1/en not_active Expired - Lifetime
- 1992-07-10 ES ES92914619T patent/ES2165357T3/es not_active Expired - Lifetime
- 1992-07-10 PT PT92914619T patent/PT552329E/pt unknown
- 1992-07-10 CA CA002091058A patent/CA2091058C/en not_active Expired - Fee Related
- 1992-07-10 EP EP19920111757 patent/EP0525472A3/en active Pending
- 1992-07-10 IE IE225392A patent/IE922253A1/en not_active Application Discontinuation
- 1992-07-10 WO PCT/EP1992/001569 patent/WO1993001182A1/en not_active Ceased
- 1992-07-10 AT AT92914619T patent/ATE206420T1/de not_active IP Right Cessation
- 1992-07-10 DE DE69232093T patent/DE69232093T2/de not_active Expired - Fee Related
- 1992-07-10 JP JP50198193A patent/JP3188701B2/ja not_active Expired - Fee Related
-
1993
- 1993-03-10 FI FI931061A patent/FI931061A0/fi not_active Application Discontinuation
- 1993-03-12 KR KR1019930700756A patent/KR930702337A/ko not_active Ceased
Non-Patent Citations (1)
| Title |
|---|
| Can. J. Chem.- 1968, v. 46, N 13, р.2189 - 2196. Chem. Rer.- 1969, v. 102 (4), р.1347 - 1356. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2236231C2 (ru) * | 1998-06-15 | 2004-09-20 | Аста Медика Акциенгезельшафт | Таблетка циклофосфамида с пленочным покрытием (варианты) и способ ее получения, ядро таблетки и способ его получения |
| RU2527526C2 (ru) * | 2009-06-25 | 2014-09-10 | Эверест Байосайенсиз Инк. | Индолил-замещенные пиразино-хинолины и их применение для лечения рака |
Also Published As
| Publication number | Publication date |
|---|---|
| GB9115160D0 (en) | 1991-08-28 |
| KR930702337A (ko) | 1993-09-08 |
| IE922253A1 (en) | 1993-01-13 |
| DE69232093T2 (de) | 2002-05-16 |
| IL102383A0 (en) | 1993-01-14 |
| ZA925169B (en) | 1993-04-28 |
| DE69232093D1 (de) | 2001-11-08 |
| FI931061A7 (fi) | 1993-03-10 |
| EP0552329A1 (en) | 1993-07-28 |
| TW202444B (enExample) | 1993-03-21 |
| ATE206420T1 (de) | 2001-10-15 |
| EP0525472A2 (en) | 1993-02-03 |
| IL102383A (en) | 1997-09-30 |
| CA2091058A1 (en) | 1993-01-13 |
| HUT67496A (en) | 1995-04-28 |
| EP0525472A3 (en) | 1993-02-24 |
| NZ243454A (en) | 1995-02-24 |
| WO1993001182A1 (en) | 1993-01-21 |
| MX9204008A (es) | 1993-01-01 |
| PT552329E (pt) | 2002-02-28 |
| JPH06501494A (ja) | 1994-02-17 |
| JP3188701B2 (ja) | 2001-07-16 |
| DK0552329T3 (da) | 2001-11-12 |
| AU656015B2 (en) | 1995-01-19 |
| CA2091058C (en) | 2004-03-30 |
| EP0552329B1 (en) | 2001-10-04 |
| ES2165357T3 (es) | 2002-03-16 |
| FI931061A0 (fi) | 1993-03-10 |
| AU2277792A (en) | 1993-02-11 |
| HU9300723D0 (en) | 1993-06-28 |
| US5409949A (en) | 1995-04-25 |
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