IL102383A - Methylene-oxindole derivatives, their preparation and pharmacetutical compositions containing them - Google Patents

Methylene-oxindole derivatives, their preparation and pharmacetutical compositions containing them

Info

Publication number
IL102383A
IL102383A IL102383A IL10238392A IL102383A IL 102383 A IL102383 A IL 102383A IL 102383 A IL102383 A IL 102383A IL 10238392 A IL10238392 A IL 10238392A IL 102383 A IL102383 A IL 102383A
Authority
IL
Israel
Prior art keywords
hydrogen
alkyl
pharmacetutical
methylene
preparation
Prior art date
Application number
IL102383A
Other languages
English (en)
Other versions
IL102383A0 (en
Inventor
Franco Buzzetti
Antonio Longo
Maristella Colombo
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of IL102383A0 publication Critical patent/IL102383A0/xx
Publication of IL102383A publication Critical patent/IL102383A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL102383A 1991-07-12 1992-07-02 Methylene-oxindole derivatives, their preparation and pharmacetutical compositions containing them IL102383A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919115160A GB9115160D0 (en) 1991-07-12 1991-07-12 Methylen-oxindole derivatives and process for their preparation

Publications (2)

Publication Number Publication Date
IL102383A0 IL102383A0 (en) 1993-01-14
IL102383A true IL102383A (en) 1997-09-30

Family

ID=10698323

Family Applications (1)

Application Number Title Priority Date Filing Date
IL102383A IL102383A (en) 1991-07-12 1992-07-02 Methylene-oxindole derivatives, their preparation and pharmacetutical compositions containing them

Country Status (22)

Country Link
US (1) US5409949A (enExample)
EP (2) EP0552329B1 (enExample)
JP (1) JP3188701B2 (enExample)
KR (1) KR930702337A (enExample)
AT (1) ATE206420T1 (enExample)
AU (1) AU656015B2 (enExample)
CA (1) CA2091058C (enExample)
DE (1) DE69232093T2 (enExample)
DK (1) DK0552329T3 (enExample)
ES (1) ES2165357T3 (enExample)
FI (1) FI931061A7 (enExample)
GB (1) GB9115160D0 (enExample)
HU (1) HUT67496A (enExample)
IE (1) IE922253A1 (enExample)
IL (1) IL102383A (enExample)
MX (1) MX9204008A (enExample)
NZ (1) NZ243454A (enExample)
PT (1) PT552329E (enExample)
RU (1) RU2072989C1 (enExample)
TW (1) TW202444B (enExample)
WO (1) WO1993001182A1 (enExample)
ZA (1) ZA925169B (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9004483D0 (en) * 1990-02-28 1990-04-25 Erba Carlo Spa New aryl-and heteroarylethenylene derivatives and process for their preparation
US5587385A (en) * 1991-12-24 1996-12-24 Farmitalia Carlo Erba S.R.L. Arylidene-heterocyclic derivatives and process for their preparation
GB9313638D0 (en) * 1993-07-01 1993-08-18 Erba Carlo Spa Arylidene and heteroarylidene oxindole derivatives and process for their preparation
GB9326136D0 (en) * 1993-12-22 1994-02-23 Erba Carlo Spa Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents
GB9406137D0 (en) * 1994-03-28 1994-05-18 Erba Carlo Spa N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation
GB9412719D0 (en) * 1994-06-24 1994-08-17 Erba Carlo Spa Substituted azaindolylidene compounds and process for their preparation
GB9501567D0 (en) * 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
GB9507298D0 (en) * 1995-04-07 1995-05-31 Pharmacia Spa Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors
US6147106A (en) 1997-08-20 2000-11-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US6906093B2 (en) 1995-06-07 2005-06-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
GB9610964D0 (en) * 1996-05-24 1996-07-31 Pharmacia & Upjohn Spa Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors
ATE308520T1 (de) * 1996-08-23 2005-11-15 Sugen Inc Kombinatorische bibliotheken von indolinone und verwandte produkte und verfahren zur behandlung von krankheiten
AU7622698A (en) * 1996-12-05 1998-06-29 Sugen, Inc. Use of indolinone compounds as modulators of protein kinases
US6051597A (en) * 1997-06-13 2000-04-18 Merck & Co., Inc. Indolylquinones as antidiabetic agents
US20040067531A1 (en) * 1997-08-20 2004-04-08 Sugen, Inc. Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6531502B1 (en) 1998-01-21 2003-03-11 Sugen, Inc. 3-Methylidenyl-2-indolinone modulators of protein kinase
US6943191B1 (en) 1998-02-27 2005-09-13 The United States Of America As Represented By The Department Of Health And Human Services Disubstituted lavendustin A analogs and pharmaceutical composition comprising the analogs
US6102942A (en) 1998-03-30 2000-08-15 Endovascular Technologies, Inc. Stent/graft deployment catheter with a stent/graft attachment mechanism
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
DE19826517B4 (de) * 1998-06-15 2006-03-23 Baxter Healthcare S.A. Verfahren zur Herstellung von Filmtabletten mit Cyclophosphamid als Wirkstoff und daraus hergestellte Cyclophosphamid-Filmtablette
AU5468499A (en) * 1998-08-04 2000-02-28 Sugen, Inc. 3-methylidenyl-2-indolinone modulators of protein kinase
US6680335B2 (en) 1998-09-28 2004-01-20 Sugen, Inc. Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
US6153634A (en) 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
ES2192877T3 (es) 1998-12-17 2003-10-16 Hoffmann La Roche 4-alquenil (y alquinil) oxindoles como inhibidores de kinasas ciclina-dependientes, en particular cdk2.
CN1136217C (zh) 1998-12-17 2004-01-28 霍夫曼-拉罗奇有限公司 作为jnk蛋白质激酶抑制剂的4-芳基羟吲哚
ATE387448T1 (de) 1998-12-17 2008-03-15 Hoffmann La Roche 4,5-pyrazinoxindole als proteinkinasehemmer
JP2000247949A (ja) * 1999-02-26 2000-09-12 Eisai Co Ltd スルホンアミド含有インドール化合物
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
US6689806B1 (en) 1999-03-24 2004-02-10 Sugen, Inc. Indolinone compounds as kinase inhibitors
EP1165513A1 (en) * 1999-03-24 2002-01-02 Sugen, Inc. Indolinone compounds as kinase inhibitors
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
RU2240826C2 (ru) 2000-02-03 2004-11-27 Эйсай Ко., Лтд. Ингибитор экспрессии интегрина
BRPI0117360B8 (pt) * 2000-02-15 2021-07-06 Upjohn Co inibidores de proteína de quinase de 2-indolinona de pirrol substituído, seus sais e composições farmacêuticas compreendendo os mesmos
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
MY128450A (en) 2000-05-24 2007-02-28 Upjohn Co 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
JP2003535847A (ja) 2000-06-02 2003-12-02 スージェン・インコーポレーテッド 蛋白質キナーゼ／ホスファターゼ阻害剤としてのインドリノン誘導体
AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
AR036042A1 (es) 2001-05-30 2004-08-04 Sugen Inc Derivados aralquilsufonil-3-(pirrol-2-ilmetiliden)-2-indolinona, sus composiciones farmaceuticas y metodo para la modulacion de la actividad catalitica de una proteina quinasa
AR038957A1 (es) * 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
JP2005508953A (ja) 2001-10-10 2005-04-07 スージェン・インコーポレーテッド キナーゼ阻害剤としての３−［４−（置換ヘテロサイクリル）−ピロール−２−イルメチリデン］−２−インドリノン誘導体
AU2003211594A1 (en) * 2002-03-05 2003-09-16 Eisai Co., Ltd. Antitumor agent comprising combination of sulfonamide-containing heterocyclic compound with angiogenesis inhibitor
US20050107819A1 (en) * 2003-11-14 2005-05-19 Medtronic Vascular, Inc. Catheter with a sectional guidewire shaft
US8772269B2 (en) * 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
WO2010149943A1 (en) * 2009-06-25 2010-12-29 Oncorel Ab New compounds and medical use
CN103274988B (zh) * 2013-06-20 2016-04-13 河北大学 3-(氰基-p-硝基苯甲撑基)-2-吲哚酮衍生物及其合成方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3310891A1 (de) * 1983-03-25 1984-09-27 Boehringer Mannheim Gmbh, 6800 Mannheim Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte
JPH03213847A (ja) * 1990-01-18 1991-09-19 Konica Corp ハロゲン化銀写真感光材料
GB9004483D0 (en) * 1990-02-28 1990-04-25 Erba Carlo Spa New aryl-and heteroarylethenylene derivatives and process for their preparation

Also Published As

Publication number Publication date
CA2091058C (en) 2004-03-30
EP0525472A3 (en) 1993-02-24
JP3188701B2 (ja) 2001-07-16
AU656015B2 (en) 1995-01-19
IE922253A1 (en) 1993-01-13
FI931061A0 (fi) 1993-03-10
TW202444B (enExample) 1993-03-21
CA2091058A1 (en) 1993-01-13
ZA925169B (en) 1993-04-28
EP0552329B1 (en) 2001-10-04
ES2165357T3 (es) 2002-03-16
FI931061A7 (fi) 1993-03-10
EP0525472A2 (en) 1993-02-03
DK0552329T3 (da) 2001-11-12
WO1993001182A1 (en) 1993-01-21
DE69232093D1 (de) 2001-11-08
PT552329E (pt) 2002-02-28
HUT67496A (en) 1995-04-28
MX9204008A (es) 1993-01-01
NZ243454A (en) 1995-02-24
GB9115160D0 (en) 1991-08-28
RU2072989C1 (ru) 1997-02-10
AU2277792A (en) 1993-02-11
JPH06501494A (ja) 1994-02-17
HU9300723D0 (en) 1993-06-28
US5409949A (en) 1995-04-25
DE69232093T2 (de) 2002-05-16
ATE206420T1 (de) 2001-10-15
IL102383A0 (en) 1993-01-14
EP0552329A1 (en) 1993-07-28
KR930702337A (ko) 1993-09-08

Similar Documents

Publication Publication Date Title
IL102383A (en) Methylene-oxindole derivatives, their preparation and pharmacetutical compositions containing them
MY109695A (en) Vinylene-azaindole derivatives and process for their preparation
WO1991013055A3 (en) New aryl- and heteroarylethenylene derivatives and process for their preparation
MXPA02011974A (es) Derivados de quinazolina sustituidos y su uso como inhibidores.
AU3700393A (en) 4,1-benzoxazepin derivatives and their use
IL110151A0 (en) Amide and urea derivatives and pharmaceutical compositions containing the same
GB9107827D0 (en) New ethanolamine derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
MY130160A (en) N-substituted b-aryl-and b-heteroaryl-a -cyanoacrylamide derivatives and process for their preparation
ES8800122A1 (es) Un procedimiento para la preparacion de derivados de indeno y naftaleno.
TW324009B (en) Pyrazole condensation ring derivative, its production process and its use as androgen inhibitor
PL326554A1 (en) Derivatives of amine and thiourea and inhibitors of nitrogen oxide synthase
IL108970A0 (en) Substituted (arylalkylaminobenzyl) aminopropionamide derivatives, their preparation and pharmaceutical compositions containing them
BG103271A (en) Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means
EP0315434A3 (en) Pyridoxal hydrazone derivatives their production and use and pharmaceutical compositions containing the same
IL115085A0 (en) Bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them
MY106176A (en) New 3''-(4-morpholinyl)-and 3''-(2-methoxy-4- morpholinyl)-anthracycline derivatives.
AU4441593A (en) Tetrahydronaphthalene derivatives, their preparation and their application in therapy
AU6924094A (en) PsoralenTM* derivatives, their preparation and use
ES2006336A6 (es) Procedimiento de preparacion de nuevas acetamidas derivadas de la 2,3-dihidro-3-fenil-2-benzofuranona.
AU6472090A (en) Dibenzodioxazecine and dibenzodioxaazacycloundecine derivatives
AU2212692A (en) N,n',n'-trisubstituted-5-bis-aminomethylene-13-dioxane-4, 6-dione inhibitors of acyl-coa:cholesterol-acyl transferase

Legal Events

Date Code Title Description
FF Patent granted
RH Patent void