RU2022105597A - Искусственно созданная система управления функцией шк - Google Patents
Искусственно созданная система управления функцией шк Download PDFInfo
- Publication number
- RU2022105597A RU2022105597A RU2022105597A RU2022105597A RU2022105597A RU 2022105597 A RU2022105597 A RU 2022105597A RU 2022105597 A RU2022105597 A RU 2022105597A RU 2022105597 A RU2022105597 A RU 2022105597A RU 2022105597 A RU2022105597 A RU 2022105597A
- Authority
- RU
- Russia
- Prior art keywords
- cas9 protein
- sequence
- crrna
- region
- guide rna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662421516P | 2016-11-14 | 2016-11-14 | |
| US62/421,516 | 2016-11-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019118283A Division RU2768043C2 (ru) | 2016-11-14 | 2017-09-28 | Искусственно созданная система управления функцией шк |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2022105597A true RU2022105597A (ru) | 2022-04-04 |
Family
ID=62109586
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2022105597A RU2022105597A (ru) | 2016-11-14 | 2017-09-28 | Искусственно созданная система управления функцией шк |
| RU2019118283A RU2768043C2 (ru) | 2016-11-14 | 2017-09-28 | Искусственно созданная система управления функцией шк |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019118283A RU2768043C2 (ru) | 2016-11-14 | 2017-09-28 | Искусственно созданная система управления функцией шк |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12331086B2 (https=) |
| EP (2) | EP3896162B1 (https=) |
| JP (1) | JP7338937B2 (https=) |
| KR (2) | KR102437228B1 (https=) |
| CN (1) | CN110248957B (https=) |
| AU (1) | AU2017358122B2 (https=) |
| BR (1) | BR112019009725A2 (https=) |
| RU (2) | RU2022105597A (https=) |
| WO (1) | WO2018088694A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020536501A (ja) * | 2017-09-28 | 2020-12-17 | ツールゲン インコーポレイテッドＴｏｏｌｇｅｎ Ｉｎｃｏｒｐｏｒａｔｅｄ | 遺伝子発現調節のための人為的なゲノム操作 |
| US11572574B2 (en) | 2017-09-28 | 2023-02-07 | Toolgen Incorporated | Artificial genome manipulation for gene expression regulation |
| EP3851528A4 (en) * | 2018-09-12 | 2023-12-06 | Institute for Basic Science | COMPOSITION FOR INDUCATING DEATH OF CELLS HAVING MUTATED GENE AND METHOD FOR INDUCATING DEATH OF CELLS HAVING MODIFIED GENE USING THE COMPOSITION |
| GB201907882D0 (en) | 2019-06-03 | 2019-07-17 | Cyprus Foundation For Muscular Dystrophy Res | Methods |
| EP3798301A1 (en) * | 2019-09-25 | 2021-03-31 | KWS SAAT SE & Co. KGaA | Promoter repression |
| WO2021184021A1 (en) * | 2020-03-13 | 2021-09-16 | Codiak Biosciences, Inc. | Extracellular vesicle-aso constructs targeting pmp22 |
| CN114621922A (zh) * | 2022-02-15 | 2022-06-14 | 中山大学附属第五医院 | 一种大鼠海绵体神经来源施旺细胞的提取纯化和培养方法 |
| WO2025079278A1 (ja) * | 2023-10-10 | 2025-04-17 | 国立大学法人 東京医科歯科大学 | シャルコー・マリー・トゥース病の処置剤 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100613038B1 (ko) * | 2004-07-07 | 2006-08-16 | 공주대학교 산학협력단 | 염색체 17ｐ11.2-ｐ12 지역의 중복을 제외한 유전자돌연변이를 발병 원인으로 하는 ＣＭＴ 질환의 진단방법및 진단키트 |
| JP2010531638A (ja) | 2007-06-12 | 2010-09-30 | ケース ウエスタン リザーブ ユニバーシティ | 標的化された細胞死 |
| AU2013335451C1 (en) | 2012-10-23 | 2024-07-04 | Toolgen Incorporated | Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof |
| EP3031921B1 (en) * | 2012-12-12 | 2025-03-12 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| WO2014204724A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation |
| WO2015048577A2 (en) * | 2013-09-27 | 2015-04-02 | Editas Medicine, Inc. | Crispr-related methods and compositions |
| CA2935032C (en) | 2013-12-26 | 2024-01-23 | The General Hospital Corporation | Multiplex guide rnas |
| WO2015188056A1 (en) | 2014-06-05 | 2015-12-10 | Sangamo Biosciences, Inc. | Methods and compositions for nuclease design |
| EP4194557A1 (en) * | 2014-08-06 | 2023-06-14 | Institute for Basic Science | Genome editing using campylobacter jejuni crispr/cas system-derived rgen |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
-
2017
- 2017-09-28 KR KR1020170126636A patent/KR102437228B1/ko active Active
- 2017-09-28 JP JP2019524226A patent/JP7338937B2/ja active Active
- 2017-09-28 CN CN201780083263.5A patent/CN110248957B/zh active Active
- 2017-09-28 RU RU2022105597A patent/RU2022105597A/ru unknown
- 2017-09-28 EP EP21166447.9A patent/EP3896162B1/en active Active
- 2017-09-28 AU AU2017358122A patent/AU2017358122B2/en active Active
- 2017-09-28 RU RU2019118283A patent/RU2768043C2/ru active
- 2017-09-28 BR BR112019009725-2A patent/BR112019009725A2/pt unknown
- 2017-09-28 EP EP17869218.2A patent/EP3539980A4/en not_active Withdrawn
- 2017-09-28 WO PCT/KR2017/010897 patent/WO2018088694A2/ko not_active Ceased
- 2017-09-28 US US16/349,672 patent/US12331086B2/en active Active
-
2022
- 2022-08-24 KR KR1020220105836A patent/KR102621539B1/ko active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20220122592A (ko) | 2022-09-02 |
| CA3043148A1 (en) | 2018-05-17 |
| EP3539980A2 (en) | 2019-09-18 |
| RU2768043C2 (ru) | 2022-03-23 |
| JP7338937B2 (ja) | 2023-09-05 |
| JP2019537446A (ja) | 2019-12-26 |
| US20190276503A1 (en) | 2019-09-12 |
| AU2017358122A1 (en) | 2019-07-04 |
| RU2019118283A3 (https=) | 2021-04-26 |
| BR112019009725A2 (pt) | 2019-11-19 |
| WO2018088694A2 (ko) | 2018-05-17 |
| EP3896162B1 (en) | 2025-03-05 |
| KR20180054427A (ko) | 2018-05-24 |
| RU2019118283A (ru) | 2020-12-14 |
| EP3539980A4 (en) | 2020-10-07 |
| CN110248957A (zh) | 2019-09-17 |
| KR102621539B1 (ko) | 2024-01-09 |
| EP3896162A1 (en) | 2021-10-20 |
| WO2018088694A3 (ko) | 2018-08-09 |
| KR102437228B1 (ko) | 2022-08-30 |
| CN110248957B (zh) | 2023-12-19 |
| US12331086B2 (en) | 2025-06-17 |
| AU2017358122B2 (en) | 2022-12-22 |
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