RU2021135194A - Способы и аппараты для подготовки клеточных популяций для клеточной терапии - Google Patents
Способы и аппараты для подготовки клеточных популяций для клеточной терапии Download PDFInfo
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- RU2021135194A RU2021135194A RU2021135194A RU2021135194A RU2021135194A RU 2021135194 A RU2021135194 A RU 2021135194A RU 2021135194 A RU2021135194 A RU 2021135194A RU 2021135194 A RU2021135194 A RU 2021135194A RU 2021135194 A RU2021135194 A RU 2021135194A
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- Prior art keywords
- stem cells
- prepared
- mesenchymal stem
- patient
- shear stress
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- 238000000034 method Methods 0.000 title claims 17
- 238000002659 cell therapy Methods 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 claims 10
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 6
- 230000006378 damage Effects 0.000 claims 4
- 230000000926 neurological effect Effects 0.000 claims 4
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000021164 cell adhesion Effects 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 230000009529 traumatic brain injury Effects 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 206010073713 Musculoskeletal injury Diseases 0.000 claims 1
- 208000038016 acute inflammation Diseases 0.000 claims 1
- 230000006022 acute inflammation Effects 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 231100000878 neurological injury Toxicity 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
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- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/04—Flat or tray type, drawers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
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- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
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- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
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- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2301—Interleukin-1 (IL-1)
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- C12N2527/00—Culture process characterised by the use of mechanical forces, e.g. strain, vibration
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Claims (20)
1. Способ лечения субъекта, нуждающегося в таком лечении, включающий введение терапевтически эффективного количества подготовленных стволовых клеток, которые были подготовлены под воздействием напряжения сдвига.
2. Способ по п. 1, отличающийся тем, что подготовленные стволовые клетки содержат подготовленные мезенхимальные стволовые клетки.
3. Способ по п. 1, отличающийся тем, что подготовленные стволовые клетки содержат композицию, полученную способом, включающим:
(a) получение исходной популяции стволовых клеток;
(b) культивирование стволовых клеток на субстрате для обеспечения адгезии клеток; и
(c) приложение контролируемого напряжения сдвига к стволовым клеткам с силой, достаточной для получения подготовленной композиции.
4. Способ по п. 1, отличающийся тем, что субъект имеет хроническое или острое воспаление, болезнь «трансплантат-против-хозяина», скелетно-мышечную травму, неврологическое повреждение или аутоиммунное расстройство.
5. Способ по п. 1, отличающийся тем, что неврологическое повреждение представляет собой травматическое повреждение головного мозга.
6. Способ по п. 1, отличающийся тем, что подготовленные стволовые клетки вводят в комбинации с одним или более дополнительными терапевтическими агентами.
7. Способ повышения числа клеток CD105+ в костном мозге пациента, включающий введение пациенту эффективного количества мезенхимальных стволовых клеток.
8. Способ по п. 7, отличающийся тем, что мезенхимальные стволовые клетки содержат клетки, которые были подготовлены под воздействием напряжения сдвига.
9. Способ по п. 7, отличающийся тем, что мезенхимальные стволовые клетки содержат подготовленную композицию, полученную способом, включающим:
(a) получение исходной популяции стволовых клеток;
(b) культивирование стволовых клеток на субстрате для обеспечения адгезии клеток; и
(c) приложение контролируемого напряжения сдвига к стволовым клеткам с силой, достаточной для получения подготовленной композиции.
10. Способ по п. 7, отличающийся тем, что пациент имеет неврологическое повреждение.
11. Способ по п. 10, отличающийся тем, что неврологическое повреждение представляет собой травматическое повреждение головного мозга.
12. Способ по п. 10, отличающийся тем, что пациент страдал от неврологического повреждения в течение менее чем 24 часов до указанного введения.
13. Способ по п. 7, отличающийся тем, что мезенхимальные стволовые клетки вводят системно.
14. Способ по п. 7, отличающийся тем, что мезенхимальные стволовые клетки вводят внутривенно.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562183273P | 2015-06-23 | 2015-06-23 | |
| US62/183,273 | 2015-06-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018102213A Division RU2761634C2 (ru) | 2015-06-23 | 2016-06-23 | Способы и аппараты для подготовки клеточных популяций для клеточной терапии |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2021135194A true RU2021135194A (ru) | 2022-01-04 |
Family
ID=57585755
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018102213A RU2761634C2 (ru) | 2015-06-23 | 2016-06-23 | Способы и аппараты для подготовки клеточных популяций для клеточной терапии |
| RU2021135194A RU2021135194A (ru) | 2015-06-23 | 2016-06-23 | Способы и аппараты для подготовки клеточных популяций для клеточной терапии |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018102213A RU2761634C2 (ru) | 2015-06-23 | 2016-06-23 | Способы и аппараты для подготовки клеточных популяций для клеточной терапии |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10669516B2 (ru) |
| EP (1) | EP3313982B1 (ru) |
| JP (2) | JP6732343B2 (ru) |
| KR (2) | KR102558605B1 (ru) |
| CN (2) | CN114561277A (ru) |
| AU (3) | AU2016281662B2 (ru) |
| BR (1) | BR112017028040A2 (ru) |
| CA (2) | CA3236202A1 (ru) |
| DK (1) | DK3313982T3 (ru) |
| FI (1) | FI3313982T3 (ru) |
| HK (1) | HK1254208A1 (ru) |
| IL (3) | IL305121A (ru) |
| RU (2) | RU2761634C2 (ru) |
| WO (1) | WO2016210150A1 (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL305121A (en) | 2015-06-23 | 2023-10-01 | Univ Texas | Methods and apparatus for growing cell populations for cell therapy |
| KR102082745B1 (ko) * | 2018-05-08 | 2020-02-28 | 주식회사 휴코드 | 항염증 성분을 분비하는 줄기세포 배양방법 및 그 줄기세포 배양액을 포함하는 항염증 조성물 |
| WO2020027336A1 (ja) * | 2018-08-03 | 2020-02-06 | 株式会社細胞応用技術研究所 | 培養上清製剤の製造方法 |
| EP3921405A1 (en) | 2019-02-05 | 2021-12-15 | Corning Incorporated | Woven cell culture substrates |
| US11118151B2 (en) | 2019-11-05 | 2021-09-14 | Corning Incorporated | Fixed bed bioreactor and methods of using the same |
| JP2023503590A (ja) * | 2019-11-27 | 2023-01-31 | コーニング インコーポレイテッド | 積層固定床バイオリアクターおよびその使用方法 |
| EP3981867A1 (en) * | 2020-10-06 | 2022-04-13 | Lonza Cologne GmbH | Device for providing a cell suspension |
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| DE2911508A1 (de) * | 1978-03-28 | 1979-10-04 | Kuraray Co | Fluidbehandlungsvorrichtung |
| US4661458A (en) | 1983-08-31 | 1987-04-28 | Cell Environmental Systems, Ltd. | Cell culture system |
| US5416022A (en) * | 1988-08-10 | 1995-05-16 | Cellex Biosciences, Inc. | Cell culture apparatus |
| US5240854A (en) * | 1989-06-05 | 1993-08-31 | Berry Eric S | Continuous high-density cell culture system |
| US5399493A (en) * | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
| GB8921458D0 (en) * | 1989-09-22 | 1989-11-08 | Univ Strathclyde | Cell culture apparatus |
| DE69026954T2 (de) * | 1990-09-19 | 1996-09-05 | Mark J Ramberg | Kontinuierliche zellkulturanlage von hoher dichtheit |
| JP2585866B2 (ja) | 1990-09-19 | 1997-02-26 | ベリー，エリック・スコット | 連続的な高密度の細胞培養システム |
| RU2164240C2 (ru) * | 1990-12-17 | 2001-03-20 | Риджентс оф дзе Юниверсити оф Мичиган | Способ культивирования, фибробласт, способ отделения клеток |
| FI100409B (fi) * | 1994-11-28 | 1997-11-28 | Asm Int | Menetelmä ja laitteisto ohutkalvojen valmistamiseksi |
| BE1009306A5 (fr) * | 1995-04-28 | 1997-02-04 | Baxter Int | Bioreacteur. |
| US5928945A (en) | 1996-11-20 | 1999-07-27 | Advanced Tissue Sciences, Inc. | Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage |
| CA2277278A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| AU5757100A (en) * | 1999-06-21 | 2001-01-09 | General Hospital Corporation, The | Methods and devices for cell culturing and organ assist systems |
| WO2004076608A2 (en) * | 2003-02-26 | 2004-09-10 | Georgia Tech Research Corporation | Bioreactor and methods for tissue growth and conditioning |
| US20080057571A1 (en) | 2006-04-28 | 2008-03-06 | North Carolina State University | Bioreactor device for exposing a cell culture to a fluid shear force imparted by a fluid flow |
| GB0808373D0 (en) | 2008-05-09 | 2008-06-18 | Synexa Life Sciences Pty Ltd | Scalable cell culture bioreactor and cell culture process |
| WO2010148275A2 (en) * | 2009-06-18 | 2010-12-23 | Kiyatec, Llc | Bioreactor system |
| US20120322097A1 (en) * | 2011-06-15 | 2012-12-20 | The Charles Stark Draper Laboratory, Inc. | Device and method for culturing cells in a biomimetic environment |
| US9599604B2 (en) | 2011-12-09 | 2017-03-21 | University Of Florida Research Foundation, Incorporated | Flow chambers, methods of using the flow chamber, and methods of making the flow chamber |
| NZ704003A (en) | 2012-06-21 | 2017-02-24 | Neostem Oncology Llc | Bioreactor cartridge and system |
| US9005550B2 (en) * | 2012-10-29 | 2015-04-14 | Corning Incorporated | Multi-layered cell culture vessel with manifold grips |
| IL305121A (en) | 2015-06-23 | 2023-10-01 | Univ Texas | Methods and apparatus for growing cell populations for cell therapy |
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- 2016-06-23 IL IL305121A patent/IL305121A/en unknown
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- 2016-06-23 JP JP2017566351A patent/JP6732343B2/ja active Active
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- 2016-06-23 KR KR1020187001978A patent/KR102558605B1/ko active IP Right Grant
- 2016-06-23 FI FIEP16815316.1T patent/FI3313982T3/fi active
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